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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ACVR2A-SUMO1 (FusionGDB2 ID:HG92TG7341) |
Fusion Gene Summary for ACVR2A-SUMO1 |
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Fusion gene information | Fusion gene name: ACVR2A-SUMO1 | Fusion gene ID: hg92tg7341 | Hgene | Tgene | Gene symbol | ACVR2A | SUMO1 | Gene ID | 92 | 7341 |
Gene name | activin A receptor type 2A | small ubiquitin like modifier 1 | |
Synonyms | ACTRII|ACVR2 | DAP1|GMP1|OFC10|PIC1|SENP2|SMT3|SMT3C|SMT3H3|UBL1 | |
Cytomap | ('ACVR2A')('SUMO1') 2q22.3-q23.1 | 2q33.1 | |
Type of gene | protein-coding | protein-coding | |
Description | activin receptor type-2Aactivin A receptor, type IIA | small ubiquitin-related modifier 1GAP modifying protein 1SMT3 homolog 3SMT3 suppressor of mif two 3 homolog 1sentrinubiquitin-homology domain protein PIC1ubiquitin-like protein SMT3Cubiquitin-like protein UBL1 | |
Modification date | 20200313 | 20200327 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000241416, ENST00000404590, ENST00000535787, ENST00000495775, | ||
Fusion gene scores | * DoF score | 8 X 7 X 7=392 | 4 X 3 X 2=24 |
# samples | 10 | 4 | |
** MAII score | log2(10/392*10)=-1.97085365434048 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ACVR2A [Title/Abstract] AND SUMO1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ACVR2A(148680680)-SUMO1(203072044), # samples:4 | ||
Anticipated loss of major functional domain due to fusion event. | ACVR2A-SUMO1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACVR2A-SUMO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ACVR2A-SUMO1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. ACVR2A-SUMO1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ACVR2A-SUMO1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. ACVR2A-SUMO1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ACVR2A | GO:0030509 | BMP signaling pathway | 18436533 |
Hgene | ACVR2A | GO:0032927 | positive regulation of activin receptor signaling pathway | 12665502 |
Hgene | ACVR2A | GO:0045648 | positive regulation of erythrocyte differentiation | 9032295 |
Tgene | SUMO1 | GO:0016925 | protein sumoylation | 11889051|14752048|15572661|15637059|15959518|17696781|19223394|21965678|24651376 |
Tgene | SUMO1 | GO:0031334 | positive regulation of protein complex assembly | 18579533 |
Tgene | SUMO1 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 18408734 |
Tgene | SUMO1 | GO:0034605 | cellular response to heat | 11514557 |
Tgene | SUMO1 | GO:0043392 | negative regulation of DNA binding | 16626738 |
Tgene | SUMO1 | GO:0045759 | negative regulation of action potential | 19223394 |
Tgene | SUMO1 | GO:0045892 | negative regulation of transcription, DNA-templated | 15572661 |
Tgene | SUMO1 | GO:0050821 | protein stabilization | 21968017 |
Tgene | SUMO1 | GO:0071276 | cellular response to cadmium ion | 11514557 |
Tgene | SUMO1 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity | 19223394 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | SARC | TCGA-FX-A2QS-01A | ACVR2A | chr2 | 148680680 | - | SUMO1 | chr2 | 203072044 | - |
ChimerDB4 | SARC | TCGA-FX-A2QS-01A | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
ChimerDB4 | SARC | TCGA-FX-A2QS | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
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Fusion Gene ORF analysis for ACVR2A-SUMO1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000241416 | ENST00000409181 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
5CDS-3UTR | ENST00000241416 | ENST00000409205 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
5CDS-3UTR | ENST00000241416 | ENST00000409498 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
5CDS-3UTR | ENST00000404590 | ENST00000409181 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
5CDS-3UTR | ENST00000404590 | ENST00000409205 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
5CDS-3UTR | ENST00000404590 | ENST00000409498 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
5CDS-3UTR | ENST00000535787 | ENST00000409181 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
5CDS-3UTR | ENST00000535787 | ENST00000409205 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
5CDS-3UTR | ENST00000535787 | ENST00000409498 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
5CDS-5UTR | ENST00000241416 | ENST00000469034 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
5CDS-5UTR | ENST00000404590 | ENST00000469034 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
5CDS-5UTR | ENST00000535787 | ENST00000469034 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
Frame-shift | ENST00000241416 | ENST00000392244 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
Frame-shift | ENST00000241416 | ENST00000392246 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
Frame-shift | ENST00000241416 | ENST00000409368 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
Frame-shift | ENST00000241416 | ENST00000409712 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
Frame-shift | ENST00000404590 | ENST00000392244 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
Frame-shift | ENST00000404590 | ENST00000392246 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
Frame-shift | ENST00000404590 | ENST00000409368 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
Frame-shift | ENST00000404590 | ENST00000409712 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
Frame-shift | ENST00000535787 | ENST00000392244 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
Frame-shift | ENST00000535787 | ENST00000392246 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
Frame-shift | ENST00000535787 | ENST00000409368 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
Frame-shift | ENST00000535787 | ENST00000409712 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
In-frame | ENST00000241416 | ENST00000392245 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
In-frame | ENST00000404590 | ENST00000392245 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
In-frame | ENST00000535787 | ENST00000392245 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
intron-3CDS | ENST00000495775 | ENST00000392244 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
intron-3CDS | ENST00000495775 | ENST00000392245 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
intron-3CDS | ENST00000495775 | ENST00000392246 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
intron-3CDS | ENST00000495775 | ENST00000409368 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
intron-3CDS | ENST00000495775 | ENST00000409712 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
intron-3UTR | ENST00000495775 | ENST00000409181 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
intron-3UTR | ENST00000495775 | ENST00000409205 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
intron-3UTR | ENST00000495775 | ENST00000409498 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
intron-5UTR | ENST00000495775 | ENST00000469034 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000535787 | ACVR2A | chr2 | 148680680 | + | ENST00000392245 | SUMO1 | chr2 | 203072044 | - | 1974 | 1288 | 90 | 1316 | 408 |
ENST00000241416 | ACVR2A | chr2 | 148680680 | + | ENST00000392245 | SUMO1 | chr2 | 203072044 | - | 2538 | 1852 | 636 | 1880 | 414 |
ENST00000404590 | ACVR2A | chr2 | 148680680 | + | ENST00000392245 | SUMO1 | chr2 | 203072044 | - | 2072 | 1386 | 170 | 1414 | 414 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000535787 | ENST00000392245 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - | 0.000259533 | 0.9997404 |
ENST00000241416 | ENST00000392245 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - | 8.03E-05 | 0.9999198 |
ENST00000404590 | ENST00000392245 | ACVR2A | chr2 | 148680680 | + | SUMO1 | chr2 | 203072044 | - | 0.000119131 | 0.9998809 |
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Fusion Genomic Features for ACVR2A-SUMO1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ACVR2A-SUMO1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:148680680/chr2:203072044) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ACVR2A | chr2:148680680 | chr2:203072044 | ENST00000241416 | + | 9 | 11 | 198_206 | 405 | 514.0 | Nucleotide binding | ATP |
Hgene | ACVR2A | chr2:148680680 | chr2:203072044 | ENST00000404590 | + | 10 | 12 | 198_206 | 405 | 514.0 | Nucleotide binding | ATP |
Hgene | ACVR2A | chr2:148680680 | chr2:203072044 | ENST00000241416 | + | 9 | 11 | 20_135 | 405 | 514.0 | Topological domain | Extracellular |
Hgene | ACVR2A | chr2:148680680 | chr2:203072044 | ENST00000404590 | + | 10 | 12 | 20_135 | 405 | 514.0 | Topological domain | Extracellular |
Hgene | ACVR2A | chr2:148680680 | chr2:203072044 | ENST00000241416 | + | 9 | 11 | 136_161 | 405 | 514.0 | Transmembrane | Helical |
Hgene | ACVR2A | chr2:148680680 | chr2:203072044 | ENST00000404590 | + | 10 | 12 | 136_161 | 405 | 514.0 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ACVR2A | chr2:148680680 | chr2:203072044 | ENST00000241416 | + | 9 | 11 | 192_485 | 405 | 514.0 | Domain | Protein kinase |
Hgene | ACVR2A | chr2:148680680 | chr2:203072044 | ENST00000404590 | + | 10 | 12 | 192_485 | 405 | 514.0 | Domain | Protein kinase |
Hgene | ACVR2A | chr2:148680680 | chr2:203072044 | ENST00000241416 | + | 9 | 11 | 162_513 | 405 | 514.0 | Topological domain | Cytoplasmic |
Hgene | ACVR2A | chr2:148680680 | chr2:203072044 | ENST00000404590 | + | 10 | 12 | 162_513 | 405 | 514.0 | Topological domain | Cytoplasmic |
Tgene | SUMO1 | chr2:148680680 | chr2:203072044 | ENST00000392244 | 2 | 4 | 20_97 | 54 | 77.0 | Domain | Ubiquitin-like | |
Tgene | SUMO1 | chr2:148680680 | chr2:203072044 | ENST00000392245 | 3 | 6 | 20_97 | 79 | 252.33333333333334 | Domain | Ubiquitin-like | |
Tgene | SUMO1 | chr2:148680680 | chr2:203072044 | ENST00000392246 | 3 | 5 | 20_97 | 79 | 102.0 | Domain | Ubiquitin-like |
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Fusion Gene Sequence for ACVR2A-SUMO1 |
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>1911_1911_1_ACVR2A-SUMO1_ACVR2A_chr2_148680680_ENST00000241416_SUMO1_chr2_203072044_ENST00000392245_length(transcript)=2538nt_BP=1852nt AGGAGACCGAAAACGCGGCCGAGCCCGGAGCCCGGAGCTGGAGCCAGAGCCTGGACCAGAACTTGGCCGCCGCCTGCACCGCCGCCGCCG CTGCCGCCCGCCGCCCCTTCCCCGCGCCGCAGCCGCCTCGCCGCCACCGCCGCGAGCTCGGCCGCCAGTGGTCCTCGGACTTTAGGTGTC TGGGTTGAAGGTCGGTCCGGACATCGGACCCAGTCAGTTCCCAGACTGTCCGGGCGGCAGCGGACGCCGCTGCCGCCGCCGCCTCTTCGT CGCCTCAGCCTGGCGTTTTGTTCCGAGAGACGGGAGAGGCGAGCGGAGCTGACAGTGATTTTGACAGTGATTTAAACCCGCTTTTGTTGT TGTTGGCTTTTCGTTGTTTGGTTTTGTGTGTTGTGCGTGTGTGTGGCGGTTTTTCCCCCGTGGTGCATTTTATTTTTTATCGTTGTGCTC TTTTTTTTCTTTTTTTTTTTTAACCCAGTGAGCGTTTTTTTTTTTTTTTTTTTTTTTTTTTGGTCTGGGCTTCCGAATATGTTTTATGAC GGTTGATTTTACACCAGGAGGTTTGTCTCCGAGGAAGACCCAGGGAACTGGATATCTAGCGAGAACTTCCTCCGGATTCCCCGGCGCCTC GGGAAAATGGGAGCTGCTGCAAAGTTGGCGTTTGCCGTCTTTCTTATCTCCTGTTCTTCAGGTGCTATACTTGGTAGATCAGAAACTCAG GAGTGTCTTTTCTTTAATGCTAATTGGGAAAAAGACAGAACCAATCAAACTGGTGTTGAACCGTGTTATGGTGACAAAGATAAACGGCGG CATTGTTTTGCTACCTGGAAGAATATTTCTGGTTCCATTGAAATAGTGAAACAAGGTTGTTGGCTGGATGATATCAACTGCTATGACAGG ACTGATTGTGTAGAAAAAAAAGACAGCCCTGAAGTATATTTTTGTTGCTGTGAGGGCAATATGTGTAATGAAAAGTTTTCTTATTTTCCG GAGATGGAAGTCACACAGCCCACTTCAAATCCAGTTACACCTAAGCCACCCTATTACAACATCCTGCTCTATTCCTTGGTGCCACTTATG TTAATTGCGGGGATTGTCATTTGTGCATTTTGGGTGTACAGGCATCACAAGATGGCCTACCCTCCTGTACTTGTTCCAACTCAAGACCCA GGACCACCCCCACCTTCTCCATTACTAGGTTTGAAACCACTGCAGTTATTAGAAGTGAAAGCAAGGGGAAGATTTGGTTGTGTCTGGAAA GCCCAGTTGCTTAACGAATATGTGGCTGTCAAAATATTTCCAATACAGGACAAACAGTCATGGCAAAATGAATACGAAGTCTACAGTTTG CCTGGAATGAAGCATGAGAACATATTACAGTTCATTGGTGCAGAAAAACGAGGCACCAGTGTTGATGTGGATCTTTGGCTGATCACAGCA TTTCATGAAAAGGGTTCACTATCAGACTTTCTTAAGGCTAATGTGGTCTCTTGGAATGAACTGTGTCATATTGCAGAAACCATGGCTAGA GGATTGGCATATTTACATGAGGATATACCTGGCCTAAAAGATGGCCACAAACCTGCCATATCTCACAGGGACATCAAAAGTAAAAATGTG CTGTTGAAAAACAACCTGACAGCTTGCATTGCTGACTTTGGGTTGGCCTTAAAATTTGAGGCTGGCAAGTCTGCAGGCGATACCCATGGA CAGGTTGGTACCCGGAGGTACATGGCTCCAGAGGTATTAGAGGGTGCTATAAACTTCCAAAGGGATGCATTTTTGAGGATAGATATGTAT GCCATGGGATTAGTCCTATGGGAACTGGCTTCTCGCTGTACTGCTGCAGATGCTGGGAATGGAGGAAGAAGATGTGATTGAAGTTTATCA GGAACAAACGGGGGGTCATTCAACAGTTTAGTTTTAAAATTTGAGGGTCTGGACCAAAAGAAGAGGAATATCAGGTTGAAGTCAAGATGA CAGATAAGGTGAGAGTAATGACTAACTCCAAAGATGGCTTCACTGAAGAAAAGGCATTTTAAGATTTTTTAAAAATCTTGTCAGAAGATC CCAGAAAAGTTCTAATTTTCATTAGCAATTAATAAAGCTATACATGCAGAAATGAATACAACAGAACACTGCTCTTTTTGATTTTATTTG TACTTTTTGGCCTGGGATATGGGTTTTAAATGGACATTGTCTGTACCAGCTTCATTAAAATAAACAATATTTGTAAAAATCATACTAATG CTTATTTTATTTTAATTGTATAGAAAGAAAAAAATGCCTAAAATAAGGTTTTCTTGCATAAATACTGGAAATTGCACATGGTACAAATTT TTTCTTCATTACTGTACAGTGATGATGTTAATGACTTTGAAGCACTGAAAGTTACTGAAGTGCCTTCTGAATCAAGGATTTAATTAAGGC CACAATACCTTTTTAATACTCAGTGTTCTGTTTTTTTAAAAACTTGATATTCCTGTATGGTGCATATATGATACAGTTACCTAATCATGT >1911_1911_1_ACVR2A-SUMO1_ACVR2A_chr2_148680680_ENST00000241416_SUMO1_chr2_203072044_ENST00000392245_length(amino acids)=414AA_BP= MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTD CVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGP PPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFH EKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQV -------------------------------------------------------------- >1911_1911_2_ACVR2A-SUMO1_ACVR2A_chr2_148680680_ENST00000404590_SUMO1_chr2_203072044_ENST00000392245_length(transcript)=2072nt_BP=1386nt GCCGCCCCTTCCCCGCGCCGCAGCCGCCTCGCCGCCACCGCCGCGAGCTCGGCCGCCAGTGGTCCTCGGACTTTAGGTGTCTGGGTTGAA GGAGGTTTGTCTCCGAGGAAGACCCAGGGAACTGGATATCTAGCGAGAACTTCCTCCGGATTCCCCGGCGCCTCGGGAAAATGGGAGCTG CTGCAAAGTTGGCGTTTGCCGTCTTTCTTATCTCCTGTTCTTCAGGTGCTATACTTGGTAGATCAGAAACTCAGGAGTGTCTTTTCTTTA ATGCTAATTGGGAAAAAGACAGAACCAATCAAACTGGTGTTGAACCGTGTTATGGTGACAAAGATAAACGGCGGCATTGTTTTGCTACCT GGAAGAATATTTCTGGTTCCATTGAAATAGTGAAACAAGGTTGTTGGCTGGATGATATCAACTGCTATGACAGGACTGATTGTGTAGAAA AAAAAGACAGCCCTGAAGTATATTTTTGTTGCTGTGAGGGCAATATGTGTAATGAAAAGTTTTCTTATTTTCCGGAGATGGAAGTCACAC AGCCCACTTCAAATCCAGTTACACCTAAGCCACCCTATTACAACATCCTGCTCTATTCCTTGGTGCCACTTATGTTAATTGCGGGGATTG TCATTTGTGCATTTTGGGTGTACAGGCATCACAAGATGGCCTACCCTCCTGTACTTGTTCCAACTCAAGACCCAGGACCACCCCCACCTT CTCCATTACTAGGTTTGAAACCACTGCAGTTATTAGAAGTGAAAGCAAGGGGAAGATTTGGTTGTGTCTGGAAAGCCCAGTTGCTTAACG AATATGTGGCTGTCAAAATATTTCCAATACAGGACAAACAGTCATGGCAAAATGAATACGAAGTCTACAGTTTGCCTGGAATGAAGCATG AGAACATATTACAGTTCATTGGTGCAGAAAAACGAGGCACCAGTGTTGATGTGGATCTTTGGCTGATCACAGCATTTCATGAAAAGGGTT CACTATCAGACTTTCTTAAGGCTAATGTGGTCTCTTGGAATGAACTGTGTCATATTGCAGAAACCATGGCTAGAGGATTGGCATATTTAC ATGAGGATATACCTGGCCTAAAAGATGGCCACAAACCTGCCATATCTCACAGGGACATCAAAAGTAAAAATGTGCTGTTGAAAAACAACC TGACAGCTTGCATTGCTGACTTTGGGTTGGCCTTAAAATTTGAGGCTGGCAAGTCTGCAGGCGATACCCATGGACAGGTTGGTACCCGGA GGTACATGGCTCCAGAGGTATTAGAGGGTGCTATAAACTTCCAAAGGGATGCATTTTTGAGGATAGATATGTATGCCATGGGATTAGTCC TATGGGAACTGGCTTCTCGCTGTACTGCTGCAGATGCTGGGAATGGAGGAAGAAGATGTGATTGAAGTTTATCAGGAACAAACGGGGGGT CATTCAACAGTTTAGTTTTAAAATTTGAGGGTCTGGACCAAAAGAAGAGGAATATCAGGTTGAAGTCAAGATGACAGATAAGGTGAGAGT AATGACTAACTCCAAAGATGGCTTCACTGAAGAAAAGGCATTTTAAGATTTTTTAAAAATCTTGTCAGAAGATCCCAGAAAAGTTCTAAT TTTCATTAGCAATTAATAAAGCTATACATGCAGAAATGAATACAACAGAACACTGCTCTTTTTGATTTTATTTGTACTTTTTGGCCTGGG ATATGGGTTTTAAATGGACATTGTCTGTACCAGCTTCATTAAAATAAACAATATTTGTAAAAATCATACTAATGCTTATTTTATTTTAAT TGTATAGAAAGAAAAAAATGCCTAAAATAAGGTTTTCTTGCATAAATACTGGAAATTGCACATGGTACAAATTTTTTCTTCATTACTGTA CAGTGATGATGTTAATGACTTTGAAGCACTGAAAGTTACTGAAGTGCCTTCTGAATCAAGGATTTAATTAAGGCCACAATACCTTTTTAA TACTCAGTGTTCTGTTTTTTTAAAAACTTGATATTCCTGTATGGTGCATATATGATACAGTTACCTAATCATGTTGAATAAATGGGCATG >1911_1911_2_ACVR2A-SUMO1_ACVR2A_chr2_148680680_ENST00000404590_SUMO1_chr2_203072044_ENST00000392245_length(amino acids)=414AA_BP= MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTD CVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGP PPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFH EKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQV -------------------------------------------------------------- >1911_1911_3_ACVR2A-SUMO1_ACVR2A_chr2_148680680_ENST00000535787_SUMO1_chr2_203072044_ENST00000392245_length(transcript)=1974nt_BP=1288nt AGGAGACCGAAAACGCGGCCGAGCCCGGAGCCCGGAGCTGGAGCCAGAGCCTGGACCAGAACTTGGCCGCCGCCTGCACCGCCGCCGCCG CTGCCGCCCGCCGCCCCTTCCCCGCGCCGCAGCCGCCTCGCCGCCACCGCCGCGAGCTCGGCCGCCAGTGGTCCTCGGACTTTAGGTGTC TGGGTTGAAGACAGAACCAATCAAACTGGTGTTGAACCGTGTTATGGTGACAAAGATAAACGGCGGCATTGTTTTGCTACCTGGAAGAAT ATTTCTGGTTCCATTGAAATAGTGAAACAAGGTTGTTGGCTGGATGATATCAACTGCTATGACAGGACTGATTGTGTAGAAAAAAAAGAC AGCCCTGAAGTATATTTTTGTTGCTGTGAGGGCAATATGTGTAATGAAAAGTTTTCTTATTTTCCGGAGATGGAAGTCACACAGCCCACT TCAAATCCAGTTACACCTAAGCCACCCTATTACAACATCCTGCTCTATTCCTTGGTGCCACTTATGTTAATTGCGGGGATTGTCATTTGT GCATTTTGGGTGTACAGGCATCACAAGATGGCCTACCCTCCTGTACTTGTTCCAACTCAAGACCCAGGACCACCCCCACCTTCTCCATTA CTAGGTTTGAAACCACTGCAGTTATTAGAAGTGAAAGCAAGGGGAAGATTTGGTTGTGTCTGGAAAGCCCAGTTGCTTAACGAATATGTG GCTGTCAAAATATTTCCAATACAGGACAAACAGTCATGGCAAAATGAATACGAAGTCTACAGTTTGCCTGGAATGAAGCATGAGAACATA TTACAGTTCATTGGTGCAGAAAAACGAGGCACCAGTGTTGATGTGGATCTTTGGCTGATCACAGCATTTCATGAAAAGGGTTCACTATCA GACTTTCTTAAGGCTAATGTGGTCTCTTGGAATGAACTGTGTCATATTGCAGAAACCATGGCTAGAGGATTGGCATATTTACATGAGGAT ATACCTGGCCTAAAAGATGGCCACAAACCTGCCATATCTCACAGGGACATCAAAAGTAAAAATGTGCTGTTGAAAAACAACCTGACAGCT TGCATTGCTGACTTTGGGTTGGCCTTAAAATTTGAGGCTGGCAAGTCTGCAGGCGATACCCATGGACAGGTTGGTACCCGGAGGTACATG GCTCCAGAGGTATTAGAGGGTGCTATAAACTTCCAAAGGGATGCATTTTTGAGGATAGATATGTATGCCATGGGATTAGTCCTATGGGAA CTGGCTTCTCGCTGTACTGCTGCAGATGCTGGGAATGGAGGAAGAAGATGTGATTGAAGTTTATCAGGAACAAACGGGGGGTCATTCAAC AGTTTAGTTTTAAAATTTGAGGGTCTGGACCAAAAGAAGAGGAATATCAGGTTGAAGTCAAGATGACAGATAAGGTGAGAGTAATGACTA ACTCCAAAGATGGCTTCACTGAAGAAAAGGCATTTTAAGATTTTTTAAAAATCTTGTCAGAAGATCCCAGAAAAGTTCTAATTTTCATTA GCAATTAATAAAGCTATACATGCAGAAATGAATACAACAGAACACTGCTCTTTTTGATTTTATTTGTACTTTTTGGCCTGGGATATGGGT TTTAAATGGACATTGTCTGTACCAGCTTCATTAAAATAAACAATATTTGTAAAAATCATACTAATGCTTATTTTATTTTAATTGTATAGA AAGAAAAAAATGCCTAAAATAAGGTTTTCTTGCATAAATACTGGAAATTGCACATGGTACAAATTTTTTCTTCATTACTGTACAGTGATG ATGTTAATGACTTTGAAGCACTGAAAGTTACTGAAGTGCCTTCTGAATCAAGGATTTAATTAAGGCCACAATACCTTTTTAATACTCAGT >1911_1911_3_ACVR2A-SUMO1_ACVR2A_chr2_148680680_ENST00000535787_SUMO1_chr2_203072044_ENST00000392245_length(amino acids)=408AA_BP= MPPAAPSPRRSRLAATAASSAASGPRTLGVWVEDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKD SPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPL LGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLS DFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYM -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ACVR2A-SUMO1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ACVR2A-SUMO1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ACVR2A-SUMO1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ACVR2A | C0920269 | Microsatellite Instability | 1 | CTD_human |
Hgene | ACVR2A | C1721098 | Replication Error Phenotype | 1 | CTD_human |
Tgene | C0008924 | Cleft upper lip | 1 | CTD_human | |
Tgene | C0008925 | Cleft Palate | 1 | CTD_human | |
Tgene | C0027626 | Neoplasm Invasiveness | 1 | CTD_human | |
Tgene | C0810364 | Cleft Lip with or without Cleft Palate | 1 | GENOMICS_ENGLAND | |
Tgene | C1837210 | OROFACIAL CLEFT 5 | 1 | GENOMICS_ENGLAND | |
Tgene | C1837218 | Cleft palate, isolated | 1 | CTD_human | |
Tgene | C1866070 | OROFACIAL CLEFT 10 | 1 | CTD_human;GENOMICS_ENGLAND |