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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:COPS2-RTKN2 (FusionGDB2 ID:HG9318TG219790) |
Fusion Gene Summary for COPS2-RTKN2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COPS2-RTKN2 | Fusion gene ID: hg9318tg219790 | Hgene | Tgene | Gene symbol | COPS2 | RTKN2 | Gene ID | 9318 | 219790 |
| Gene name | COP9 signalosome subunit 2 | rhotekin 2 | |
| Synonyms | ALIEN|CSN2|SGN2|TRIP15 | PLEKHK1|bA531F24.1 | |
| Cytomap | ('COPS2')('RTKN2') 15q21.1 | 10q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | COP9 signalosome complex subunit 2COP9 constitutive photomorphogenic homolog subunit 2JAB1-containing signalosome subunit 2TR-interacting protein 15TRIP-15alien homologsignalosome subunit 2thyroid receptor-interacting protein 15 | rhotekin-2PH domain-containing family K member 1pleckstrin homology domain-containing family K member 1 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000299259, ENST00000388901, ENST00000542928, | ||
| Fusion gene scores | * DoF score | 7 X 4 X 4=112 | 12 X 9 X 8=864 |
| # samples | 7 | 11 | |
| ** MAII score | log2(7/112*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/864*10)=-2.97352778863881 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: COPS2 [Title/Abstract] AND RTKN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | COPS2(49447722)-RTKN2(63964781), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | COPS2-RTKN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. COPS2-RTKN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. COPS2-RTKN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. COPS2-RTKN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | COPS2 | GO:0000338 | protein deneddylation | 19141280 |
| Hgene | COPS2 | GO:0006468 | protein phosphorylation | 9535219 |
| Fusion gene breakpoints across COPS2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across RTKN2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-BR-8058-01A | COPS2 | chr15 | 49447722 | - | RTKN2 | chr10 | 63964781 | - |
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Fusion Gene ORF analysis for COPS2-RTKN2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000299259 | ENST00000395260 | COPS2 | chr15 | 49447722 | - | RTKN2 | chr10 | 63964781 | - |
| 5CDS-intron | ENST00000388901 | ENST00000395260 | COPS2 | chr15 | 49447722 | - | RTKN2 | chr10 | 63964781 | - |
| 5CDS-intron | ENST00000542928 | ENST00000395260 | COPS2 | chr15 | 49447722 | - | RTKN2 | chr10 | 63964781 | - |
| In-frame | ENST00000299259 | ENST00000315289 | COPS2 | chr15 | 49447722 | - | RTKN2 | chr10 | 63964781 | - |
| In-frame | ENST00000299259 | ENST00000373789 | COPS2 | chr15 | 49447722 | - | RTKN2 | chr10 | 63964781 | - |
| In-frame | ENST00000299259 | ENST00000395265 | COPS2 | chr15 | 49447722 | - | RTKN2 | chr10 | 63964781 | - |
| In-frame | ENST00000388901 | ENST00000315289 | COPS2 | chr15 | 49447722 | - | RTKN2 | chr10 | 63964781 | - |
| In-frame | ENST00000388901 | ENST00000373789 | COPS2 | chr15 | 49447722 | - | RTKN2 | chr10 | 63964781 | - |
| In-frame | ENST00000388901 | ENST00000395265 | COPS2 | chr15 | 49447722 | - | RTKN2 | chr10 | 63964781 | - |
| In-frame | ENST00000542928 | ENST00000315289 | COPS2 | chr15 | 49447722 | - | RTKN2 | chr10 | 63964781 | - |
| In-frame | ENST00000542928 | ENST00000373789 | COPS2 | chr15 | 49447722 | - | RTKN2 | chr10 | 63964781 | - |
| In-frame | ENST00000542928 | ENST00000395265 | COPS2 | chr15 | 49447722 | - | RTKN2 | chr10 | 63964781 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000388901 | COPS2 | chr15 | 49447722 | - | ENST00000315289 | RTKN2 | chr10 | 63964781 | - | 1916 | 128 | 74 | 628 | 184 |
| ENST00000388901 | COPS2 | chr15 | 49447722 | - | ENST00000395265 | RTKN2 | chr10 | 63964781 | - | 629 | 128 | 74 | 628 | 185 |
| ENST00000388901 | COPS2 | chr15 | 49447722 | - | ENST00000373789 | RTKN2 | chr10 | 63964781 | - | 5652 | 128 | 74 | 937 | 287 |
| ENST00000299259 | COPS2 | chr15 | 49447722 | - | ENST00000315289 | RTKN2 | chr10 | 63964781 | - | 1925 | 137 | 83 | 637 | 184 |
| ENST00000299259 | COPS2 | chr15 | 49447722 | - | ENST00000395265 | RTKN2 | chr10 | 63964781 | - | 638 | 137 | 83 | 637 | 185 |
| ENST00000299259 | COPS2 | chr15 | 49447722 | - | ENST00000373789 | RTKN2 | chr10 | 63964781 | - | 5661 | 137 | 83 | 946 | 287 |
| ENST00000542928 | COPS2 | chr15 | 49447722 | - | ENST00000315289 | RTKN2 | chr10 | 63964781 | - | 1868 | 80 | 26 | 580 | 184 |
| ENST00000542928 | COPS2 | chr15 | 49447722 | - | ENST00000395265 | RTKN2 | chr10 | 63964781 | - | 581 | 80 | 26 | 580 | 185 |
| ENST00000542928 | COPS2 | chr15 | 49447722 | - | ENST00000373789 | RTKN2 | chr10 | 63964781 | - | 5604 | 80 | 26 | 889 | 287 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000388901 | ENST00000315289 | COPS2 | chr15 | 49447722 | - | RTKN2 | chr10 | 63964781 | - | 0.001497959 | 0.998502 |
| ENST00000388901 | ENST00000395265 | COPS2 | chr15 | 49447722 | - | RTKN2 | chr10 | 63964781 | - | 0.001760617 | 0.9982394 |
| ENST00000388901 | ENST00000373789 | COPS2 | chr15 | 49447722 | - | RTKN2 | chr10 | 63964781 | - | 0.000609744 | 0.99939024 |
| ENST00000299259 | ENST00000315289 | COPS2 | chr15 | 49447722 | - | RTKN2 | chr10 | 63964781 | - | 0.001903922 | 0.99809605 |
| ENST00000299259 | ENST00000395265 | COPS2 | chr15 | 49447722 | - | RTKN2 | chr10 | 63964781 | - | 0.002054958 | 0.997945 |
| ENST00000299259 | ENST00000373789 | COPS2 | chr15 | 49447722 | - | RTKN2 | chr10 | 63964781 | - | 0.000614543 | 0.9993855 |
| ENST00000542928 | ENST00000315289 | COPS2 | chr15 | 49447722 | - | RTKN2 | chr10 | 63964781 | - | 0.00211066 | 0.99788934 |
| ENST00000542928 | ENST00000395265 | COPS2 | chr15 | 49447722 | - | RTKN2 | chr10 | 63964781 | - | 0.001507389 | 0.9984926 |
| ENST00000542928 | ENST00000373789 | COPS2 | chr15 | 49447722 | - | RTKN2 | chr10 | 63964781 | - | 0.000604457 | 0.9993955 |
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Fusion Genomic Features for COPS2-RTKN2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for COPS2-RTKN2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:49447722/chr10:63964781) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | RTKN2 | chr15:49447722 | chr10:63964781 | ENST00000395260 | 0 | 5 | 56_91 | 0 | 164.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | RTKN2 | chr15:49447722 | chr10:63964781 | ENST00000395260 | 0 | 5 | 286_393 | 0 | 164.0 | Domain | PH | |
| Tgene | RTKN2 | chr15:49447722 | chr10:63964781 | ENST00000395260 | 0 | 5 | 5_81 | 0 | 164.0 | Domain | REM-1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | COPS2 | chr15:49447722 | chr10:63964781 | ENST00000299259 | - | 1 | 13 | 254_416 | 18 | 451.0 | Domain | PCI |
| Hgene | COPS2 | chr15:49447722 | chr10:63964781 | ENST00000388901 | - | 1 | 13 | 254_416 | 18 | 444.0 | Domain | PCI |
| Tgene | RTKN2 | chr15:49447722 | chr10:63964781 | ENST00000373789 | 8 | 12 | 56_91 | 340 | 610.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | RTKN2 | chr15:49447722 | chr10:63964781 | ENST00000395265 | 9 | 14 | 56_91 | 361 | 528.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | RTKN2 | chr15:49447722 | chr10:63964781 | ENST00000373789 | 8 | 12 | 286_393 | 340 | 610.0 | Domain | PH | |
| Tgene | RTKN2 | chr15:49447722 | chr10:63964781 | ENST00000373789 | 8 | 12 | 5_81 | 340 | 610.0 | Domain | REM-1 | |
| Tgene | RTKN2 | chr15:49447722 | chr10:63964781 | ENST00000395265 | 9 | 14 | 286_393 | 361 | 528.0 | Domain | PH | |
| Tgene | RTKN2 | chr15:49447722 | chr10:63964781 | ENST00000395265 | 9 | 14 | 5_81 | 361 | 528.0 | Domain | REM-1 |
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Fusion Gene Sequence for COPS2-RTKN2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >18631_18631_1_COPS2-RTKN2_COPS2_chr15_49447722_ENST00000299259_RTKN2_chr10_63964781_ENST00000315289_length(transcript)=1925nt_BP=137nt AAGAAGCTGAGAGTGACGCCTCTGAGCCGCGGAGGATTGTGGGAGGAGGTTGTCTCCAATTTCTCCTCCCCCTCCCGGCCAAGATGTCTG ACATGGAGGATGATTTCATGTGCGATGATGAGGAGGACTACGACCTGGAAACCAGAATCCGGGCAATGGATAAGGATGCCAAGAAAAGAA TCCATAATTTCTCTGTCATCAATCCTGTTCCTGGACAAGCTATAACTCAGATTTTTGCAGTTGACAATAGAGAAGATCTTCAGAAGTGGA TGGAAGCCTTCTGGCAGCATTTCTTTGATCTTAGCCAATGGAAGCACTGTTGTGAAGAACTTATGAAAATTGAGATTATGTCACCACGGA AACCACCTTTGTTCTTGACAAAAGAGGCAACCTCAGTCTACCATGATATGAGCATTGATTCACCTATGAAACTTGAAAGTTTAACGGATA TAATACAAAAAAAAATTGAAGAGACAAATGGGCAGTTCCTTATTGGTCAGCATGAAGAATCCTTACCACCTCCTTGGGCCACACTCTTTG ATGGTAACCATCAAATGGTCATCCAGAAAAAGAATAATAGTAATCAACTACATAATCTCCAGAAACTGCCAGCAACTTCCAAATTCCTCT TCACATAGCTTCTCAAATACTTCATTAGAACCAGTGTGAAAAATTTAAAATACAATGTGACATTTCTCTAGTAGAATGTAAGCTTCATGA GGGAAAAGACAACGCGTCTCCTTCCTGTATTCCTAGCACCCAGTACGGCACCTGACACATAATAGTGACCTTAGAAGAATATTTAAGAGT CATTGAGTAAACATTTTGTAGAGCTGTCCATGTTTATTTTCCATTCAGTGTTTACCAGGTGTCTGCTATTTGGACAGTCACTTCATTGTT CATTAGTACATGACTTTGGTAAATATATCTCCTGTGAAGAGAAATATTATAACTACTATGGCATTCAACACTGGTATTTCAGTTACTCAA CTAATCCACCCACTGATGGAGTGAACCTTGAATTAAATGCTTTGAAGAATAAAGTGAATCTTGATAAAAATCAAAGGCTGAAGAAATCTT GTTTGACAGAAGGCATGAACAAAAATGCTAAAATTAATACTGTTTGTGGAGAAACACTCATTCCACCGCAGACTAAATGGAGTTCATGAG TATCAAAATGCCTATGTGATCAAAAGGCAGAAACAGCTTCTTTTTACTAGGTCTGTTAATATTCCAGGACTCATAATATTGTGCCTACAT GAGCACCTGTGTTTGTGGTAACTCAAAGTATTTGAACACCTTATCTCATCCAACCTCAAATTTCCTGTGAGGTATTTAAGCACCGAGAGC TCTTGGTACTGTTTTCAAGATGAAGCAGATGAATTAGAGAGGCTGTTCACACACCAAATTTCACAGAAGCCTATGGAGGAAATGACGGGG AGACTTACCAGTTAACACCCAGTTGCAGAAATCAATGTCAGAGCTTGAAAGGACCTTATAAACCCCTGATCCAATGTGGACTTTCCTAGT AAGACTTCTGTTTGCAGTGACTTGGTTCATTTCACCAACCACAAGAATTTTAAGTAATTTTTAATCATAAAAGTAACATAGAACATAGTA ATACATATATACGTACATACATGATACAGAAAGGTATCAAAAAACAAAAACATATATTACTTCCTCCTCTAACATTCCAGTGCCAGTTTC CAAAGATTCCTATTACCCAGAGGTAACCACTGTTAATAATTTTTAATGTATATTTCCAAAAATTTTTTATGCATTTAGAAATGTGTGCAT GTGGGTGATGGGTGCACCAAAATCTCAGAAATCACCACTAAAGAACTTACTCATGTAACCAAACACCATGTGGTCCCCCAAAAACCTATT >18631_18631_1_COPS2-RTKN2_COPS2_chr15_49447722_ENST00000299259_RTKN2_chr10_63964781_ENST00000315289_length(amino acids)=184AA_BP=18 MSDMEDDFMCDDEEDYDLETRIRAMDKDAKKRIHNFSVINPVPGQAITQIFAVDNREDLQKWMEAFWQHFFDLSQWKHCCEELMKIEIMS PRKPPLFLTKEATSVYHDMSIDSPMKLESLTDIIQKKIEETNGQFLIGQHEESLPPPWATLFDGNHQMVIQKKNNSNQLHNLQKLPATSK -------------------------------------------------------------- >18631_18631_2_COPS2-RTKN2_COPS2_chr15_49447722_ENST00000299259_RTKN2_chr10_63964781_ENST00000373789_length(transcript)=5661nt_BP=137nt AAGAAGCTGAGAGTGACGCCTCTGAGCCGCGGAGGATTGTGGGAGGAGGTTGTCTCCAATTTCTCCTCCCCCTCCCGGCCAAGATGTCTG ACATGGAGGATGATTTCATGTGCGATGATGAGGAGGACTACGACCTGGAAACCAGAATCCGGGCAATGGATAAGGATGCCAAGAAAAGAA TCCATAATTTCTCTGTCATCAATCCTGTTCCTGGACAAGCTATAACTCAGATTTTTGCAGTTGACAATAGAGAAGATCTTCAGAAGTGGA TGGAAGCCTTCTGGCAGCATTTCTTTGATCTTAGCCAATGGAAGCACTGTTGTGAAGAACTTATGAAAATTGAGATTATGTCACCACGGA AACCACCTTTGTTCTTGACAAAAGAGGCAACCTCAGTCTACCATGATATGAGCATTGATTCACCTATGAAACTTGAAAGTTTAACGGATA TAATACAAAAAAAAATTGAAGAGACAAATGGGCAGTTCCTTATTGGTCAGCATGAAGAATCCTTACCACCTCCTTGGGCCACACTCTTTG ATGGTAACCATCAAATGGTCATCCAGAAAAAGGTACTGTATCCTGCAAGTGAGCCATTACATGATGAAAAAGGGAAAAAGAGACAAGCTC CCCTTCCTCCTTCTGATAAACTTCCATTCAGCTTAAAATCACAGAGTAACACAGATCAATTGGTTAAGGACAACTGGGGAAAAACAAGTG TATCTCAGACATCGTCTTTGGATACCAAACTATCAACTCTAATGCATCACTTACAGAAACCAATGGCTGCTCCTCGAAAACTTCTGCCTG CCAGGAGAAATAGATTAAGTGATGGTGAGCACACAGACACTAAAACCAATTTTGAAGCCAAGCCAGTGCCAGCTCCAAGGCAGAAATCCA TCAAAGACATTCTGGACCCTAGATCATGGCTGCAGGCACAAGTATAGAAAACTCTTAATGATAAAACATTTAACAAAATCTATAACTGTG AAGCTTAATTCAGAGGCATTATAGAATAATGTGTAATTATATAGGTAAATATAGTGATTTATACCAATAATTAATAAGCTATTAGGTATA GAAAAACATTTTATAATGAAGAAGTGGATTTCTCTTTTACTCCTGATTTGCAGAATGTAAGTGATTTCTCCAGCAGTGTGCAAGAGGCAG TTTCTAGACAATATCCTAATTGTTGGAAGGGTTAATTTATTCCTGAATTAGTACCAGGCAGTGAATAAGCCCTAGGCAGAATAAAGCATT AAAATTTCTTTTGGGGAGAGACTGTCTAGTAATTTAAAATGTGTTAAATATGAACCATATTCTCATTGTGAGAATTTTAATACTAATGGA ATGTTTCAAAGGTTTTATTCAAACCACAAATTATAGAATCCACCCAAGAAAATTTTCTTAGCATTCTGGAATTCTCATCTAATGGTTCAC TGGCTCTCATCTATTGTTTAACTCACTAGTTTATAGGCCTGACCTTTTAAATTCCTGGGATAAATTTTAGAATATTAAATTCTTCATCTT TAAAGGGAATTTGTAATGTGCTATTCAAACTTGTTTCCTTGATGAGCCCTGAAATACTGTTGACATTAACTTTCATAAATGAAGCATAAC ACTTACTAGTTTAGAGAAATGGTAGATGAAATGCTCTTTACATTCAATTTTCTGTGTGTGGTGCTAATTTCCATTGTGACTTTGGAATTT AGGGAAGTGAGTAGCTGATCAACACCTTAAAATTCATTTAATACTTATTTAAAAAGAAGATGAGAGATTCAAAAATATCAGAAAAGTTGG CCATGGTAAATAATTTTCAGAATTCTTTTTTAAAATTTTAATTAGATTTCCTTTTCCTAGTAAGAGTTGATGTCTGCTAGTGGTATTTTT CATTAAATGTCATATTCTTACAACAGTGACATTGGAATCATTTCCATAGGAGGTAATTTCCATAGCAACTAATCATAGTGACCCAAACAG GATTATAAAGTCAAGTGAGGAATAAATAGCAGAAAAATACCTTAAAGGAACAAAAAATCCATTTTTTATAATAATGCTTTTTGTAAACAA GAGCAGAACAGTTTTAAAAATCTAATTAGAATTTCCAAATAAAACAGTTTCCATAAGGTGTCAGCAACAGCACTAAAAATCTCAAATCAC ACTGAACCCTAAATGTCATTGCAAGAAATAAAAATTTAAGAATTAAATTGCTGCCCTGTGTATAATCTCTTGAGATCTTTTTAAAGCTAG CAAGAACTCTATTTGGATCAGAACTACATTATTACAAAACAAAATGAACACTTGACCAAAAAACCACATTAATTTAAATGGAGCCTTTCA TTATTTTCAGATAGCGGGGTCTTTTCCATTTATAGAGAATGATGTAACTGCCAGGACACTTTTGTGTTTGCCCAGGACTCCTAGTAAGAA TTGAATCTTGAGGGAGTAATGATAACAAAAGGTTTCTTGTGACTGGTAACATCAGGACAGACAGAGTTTTTGGTGAGAAGAAAGTACTAT ATGCCTGCTTGATAGCATGTAGAGATCATCACATGTATGGAAACCTTAAAAAGTAAACTTATTTTTTCTAACTAGAAGGCTCTCATAAGT TTCTGTTATGATTGCCATTTCAATAAATGACATTAAAAATCTAAAGGATATTATTGTTTGAATTTTTGGGTTATTTTTTAAAACTTCATT GCTGTTTTTGACAGCATTTGTGACTGTCATTGCCACTAAATTATTGAGCTAGAAGATGCTGCAGGGAAAATTGTTTTGAAGCTGGCATCT AAGCATTCTTTTTTTTTTCCTAGTTGATGCCTTCCTTTATTACAAATCAGTATTAAAACTTCCAGATTATATTCTTGTCATTTTTCCTCA TGCAGATAACAGCAGGAAGGACTTAAGGTGTATAAGAAAAAGAAAGTATTCATACAGAAATTACCTAGCAGTTGTGCCCTCAGAGTAGAA CTTTGAAACAGGACTGAAGCCCTTTTTACCTAGAACCATTTAAAAGCCTGAGCAAGGACCACCACCCCCTCCCCACCAAATTATTCGGTC TCTTTCTGGGGGGCCCAGCTTACTGTATGTTACAAGTCTTTGAAATGGGTCTGGTGTCTTCAGCTCCTGAAATGCTAATTTACCCCTTAC CTAAGGAGTGTAGTTATAATACAGAGTTGGTTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTC CTTCCTTCATTCCCTCTGTCCGTCTCTCCTTCCCTCCTTCCCTCCTTCCTTCCTTTTTGTCTTTGTTTCTTTCTCTGGCCCCCTGTCCTC TCTCTCTGTCTCATCCCCTTTTCCCACTTTCCTTCTGTCTCTCCTTCCTCCCTTCCTTTACAGTTTAAAAAAAAAATCTAAAAATAGTTA AGCACTGTGTCAAAGAGTGTTTCAAAAGAATTGTTTGTTTTCTCATTTCTTAAACCAGAAGTTTATGACAAATAAATATGCCATGTAATA TGAAAGCTGCTTCAGCTTTTTATGAGCTTTCACATTCCTTGTTTGTCCTTTTAATTTGTTTCTTGATATATGAAGACTATAAACTTGAAA CAAAGAGTTAGCTGTCAGCTCTTGATAATATAATTGGGGAAACAGAATAGATATTTTATGATATGATAATTCTGATGATCTAAAGATAAT GTCTTAGACAATTACCTTTACATTTCAAGCTCTGGGATATAAATTACGTAGTCAGCATTAAGATAGTATTATTTTTAATTGCTACTAAGT GGTAACTTTTGTATTTTAATATCTTGCAAGGGCAAAGAAGGCATTTTTAAAATTCTAAATGCACACCTCCTAAGGTAAATAGTCTTTCAA AAATATCAGGCGTGCCAACTCTTGCTGAGTTTTGTTAAATCCTCCTTAACTGTCTGCAGTGCCCCCTGACTTCTTTTAAATGGATGTGAA TATATGTGGAAAACTAAATCCATTTATTATAAATGCCTTATCTTTACCCTTTGGGATCTTACTAAATGCATTTTACCTGCTACTATTTAT TAAAAATGGAAGCTGTCTTGAATTAGAGATACCTCACGTAAGGTAGGTTAAGCAGTCAAGTATTTCTTTAGGCTTATGTTCAGCACCTCA GCCCCCTACTGAGAAGTTAATTAATTCAGTCCAAAATGAAATTATAGGGCAGTTTGGTGCAATTTATGTTAAATGCCATTTGAATGTAAT CACCTGTGTTACCACGAATGAGGCACAACTATACTACATGGACAGAGTACTGCATTGCACCATGAGCAAGAACTGCTCTGCAAGAAAAAT ATCTGTCCCTGTGGTCTGAATTTATCAAAACTCATTTTCTTGTTAAAGAGTGAATTATTGAATAGTAATTAAACTTTAACTGATGACCAT TTATATTCTAGTAGCCATCTTCACTGTTAGTCTTAAATTATAATGTAAAGTTGACATTTTCCCCTTACATTTCAAAGGCATCACTATTTT TAAATGTTTACATATGTTTACATGTTTGTGTGCAACTGCTTCATTGCTATTAATAGTTAAATGAAATCTGCATATTCTGGATCATAGATG TTCTTAGTTAACTCTGGGAAAGATGTTACCTTTGGGTTTTTAAAAGACAAGTCATCATTTGAAAATATATTAGGGTGTGTTGATTTTCTG ACATGCTTGTGTAATTGGCTTTGTTTATAATTTTTATTTTTTAATATGGGTCAGACTTTTGGATTAAAAAGTATTATATCATGGACATAC ATTTTTTAAAGTACCAAAGGTATTTGGTAAGCGAGCCCAAGTCATGTAATTGAAACTTCTGTACATTAAAAGAACTGATTCATGAAGACG TTTTCTAACTTTTTCTCTTTAAGTGCTCCTCTAGACTAGACTGATTGAAGTAGACAGTGTGGTGGAATCAGTTTAATCAGAAAAAGACAT ACCAAGTAGCTGGTGCTAATTATTATAAGACTAACATTCTGATAAGCCATGGTATAATTAACATTATTAAAATGTTTACATATAATCCTT CTTAAAGTATACTCTTTTAAAAATCCATTGACATAACCTTACTTTTAGTTTAGTGATCCAGAATTTCCCCAGAGCTTAAGCCACTGCAGT AAATTAGGTACGTAGGATATTCAGTCGCTACTAGCCACAAGGAGTCTCCTTATTTTAATGTACCTCCCTCAGTACTTTATTCCTGCAGAG CGCCTCAGAGTGGGGGAGAGAAATGAGCAATCCTGGCTCAGTTGGATTATTTCAGCATTTTATTTCTAAATCTGTAGTGTGATCAGAAAT ATTTAAAATTAAAAAAATACTTTACAGAGAGAGGCCTACTAATCAATGTGCTTAGAGAAACAAACTACCTTTACATTCAATTAACAACAA AAAAAGTTACAGAAATTTTAACAAACATTTTTCTTTATCTGAGTATGGGAGAAAATACTAATGCTGACACGTTTAATAATTAGAAAAGAT CATTCCAGATCTTATGGAAAATTGTGTTTTAAATTCCAGCAGTTTGCTCTTGAGACATGGTAATCTCTTAATGTAACTACTAAAGGAGAG >18631_18631_2_COPS2-RTKN2_COPS2_chr15_49447722_ENST00000299259_RTKN2_chr10_63964781_ENST00000373789_length(amino acids)=287AA_BP=18 MSDMEDDFMCDDEEDYDLETRIRAMDKDAKKRIHNFSVINPVPGQAITQIFAVDNREDLQKWMEAFWQHFFDLSQWKHCCEELMKIEIMS PRKPPLFLTKEATSVYHDMSIDSPMKLESLTDIIQKKIEETNGQFLIGQHEESLPPPWATLFDGNHQMVIQKKVLYPASEPLHDEKGKKR QAPLPPSDKLPFSLKSQSNTDQLVKDNWGKTSVSQTSSLDTKLSTLMHHLQKPMAAPRKLLPARRNRLSDGEHTDTKTNFEAKPVPAPRQ -------------------------------------------------------------- >18631_18631_3_COPS2-RTKN2_COPS2_chr15_49447722_ENST00000299259_RTKN2_chr10_63964781_ENST00000395265_length(transcript)=638nt_BP=137nt AAGAAGCTGAGAGTGACGCCTCTGAGCCGCGGAGGATTGTGGGAGGAGGTTGTCTCCAATTTCTCCTCCCCCTCCCGGCCAAGATGTCTG ACATGGAGGATGATTTCATGTGCGATGATGAGGAGGACTACGACCTGGAAACCAGAATCCGGGCAATGGATAAGGATGCCAAGAAAAGAA TCCATAATTTCTCTGTCATCAATCCTGTTCCTGGACAAGCTATAACTCAGATTTTTGCAGTTGACAATAGAGAAGATCTTCAGAAGTGGA TGGAAGCCTTCTGGCAGCATTTCTTTGATCTTAGCCAATGGAAGCACTGTTGTGAAGAACTTATGAAAATTGAGATTATGTCACCACGGA AACCACCTTTGTTCTTGACAAAAGAGGCAACCTCAGTCTACCATGATATGAGCATTGATTCACCTATGAAACTTGAAAGTTTAACGGATA TAATACAAAAAAAAATTGAAGAGACAAATGGGCAGTTCCTTATTGGTCAGCATGAAGAATCCTTACCACCTCCTTGGGCCACACTCTTTG ATGGTAACCATCAAATGGTCATCCAGAAAAAGAATAATAGTAATCAACTACATAATCTCCAGAAACTGCCAGCAACTTCCAAATTCCTCT >18631_18631_3_COPS2-RTKN2_COPS2_chr15_49447722_ENST00000299259_RTKN2_chr10_63964781_ENST00000395265_length(amino acids)=185AA_BP=18 MSDMEDDFMCDDEEDYDLETRIRAMDKDAKKRIHNFSVINPVPGQAITQIFAVDNREDLQKWMEAFWQHFFDLSQWKHCCEELMKIEIMS PRKPPLFLTKEATSVYHDMSIDSPMKLESLTDIIQKKIEETNGQFLIGQHEESLPPPWATLFDGNHQMVIQKKNNSNQLHNLQKLPATSK -------------------------------------------------------------- >18631_18631_4_COPS2-RTKN2_COPS2_chr15_49447722_ENST00000388901_RTKN2_chr10_63964781_ENST00000315289_length(transcript)=1916nt_BP=128nt AGAGTGACGCCTCTGAGCCGCGGAGGATTGTGGGAGGAGGTTGTCTCCAATTTCTCCTCCCCCTCCCGGCCAAGATGTCTGACATGGAGG ATGATTTCATGTGCGATGATGAGGAGGACTACGACCTGGAAACCAGAATCCGGGCAATGGATAAGGATGCCAAGAAAAGAATCCATAATT TCTCTGTCATCAATCCTGTTCCTGGACAAGCTATAACTCAGATTTTTGCAGTTGACAATAGAGAAGATCTTCAGAAGTGGATGGAAGCCT TCTGGCAGCATTTCTTTGATCTTAGCCAATGGAAGCACTGTTGTGAAGAACTTATGAAAATTGAGATTATGTCACCACGGAAACCACCTT TGTTCTTGACAAAAGAGGCAACCTCAGTCTACCATGATATGAGCATTGATTCACCTATGAAACTTGAAAGTTTAACGGATATAATACAAA AAAAAATTGAAGAGACAAATGGGCAGTTCCTTATTGGTCAGCATGAAGAATCCTTACCACCTCCTTGGGCCACACTCTTTGATGGTAACC ATCAAATGGTCATCCAGAAAAAGAATAATAGTAATCAACTACATAATCTCCAGAAACTGCCAGCAACTTCCAAATTCCTCTTCACATAGC TTCTCAAATACTTCATTAGAACCAGTGTGAAAAATTTAAAATACAATGTGACATTTCTCTAGTAGAATGTAAGCTTCATGAGGGAAAAGA CAACGCGTCTCCTTCCTGTATTCCTAGCACCCAGTACGGCACCTGACACATAATAGTGACCTTAGAAGAATATTTAAGAGTCATTGAGTA AACATTTTGTAGAGCTGTCCATGTTTATTTTCCATTCAGTGTTTACCAGGTGTCTGCTATTTGGACAGTCACTTCATTGTTCATTAGTAC ATGACTTTGGTAAATATATCTCCTGTGAAGAGAAATATTATAACTACTATGGCATTCAACACTGGTATTTCAGTTACTCAACTAATCCAC CCACTGATGGAGTGAACCTTGAATTAAATGCTTTGAAGAATAAAGTGAATCTTGATAAAAATCAAAGGCTGAAGAAATCTTGTTTGACAG AAGGCATGAACAAAAATGCTAAAATTAATACTGTTTGTGGAGAAACACTCATTCCACCGCAGACTAAATGGAGTTCATGAGTATCAAAAT GCCTATGTGATCAAAAGGCAGAAACAGCTTCTTTTTACTAGGTCTGTTAATATTCCAGGACTCATAATATTGTGCCTACATGAGCACCTG TGTTTGTGGTAACTCAAAGTATTTGAACACCTTATCTCATCCAACCTCAAATTTCCTGTGAGGTATTTAAGCACCGAGAGCTCTTGGTAC TGTTTTCAAGATGAAGCAGATGAATTAGAGAGGCTGTTCACACACCAAATTTCACAGAAGCCTATGGAGGAAATGACGGGGAGACTTACC AGTTAACACCCAGTTGCAGAAATCAATGTCAGAGCTTGAAAGGACCTTATAAACCCCTGATCCAATGTGGACTTTCCTAGTAAGACTTCT GTTTGCAGTGACTTGGTTCATTTCACCAACCACAAGAATTTTAAGTAATTTTTAATCATAAAAGTAACATAGAACATAGTAATACATATA TACGTACATACATGATACAGAAAGGTATCAAAAAACAAAAACATATATTACTTCCTCCTCTAACATTCCAGTGCCAGTTTCCAAAGATTC CTATTACCCAGAGGTAACCACTGTTAATAATTTTTAATGTATATTTCCAAAAATTTTTTATGCATTTAGAAATGTGTGCATGTGGGTGAT GGGTGCACCAAAATCTCAGAAATCACCACTAAAGAACTTACTCATGTAACCAAACACCATGTGGTCCCCCAAAAACCTATTGAAATAAAT >18631_18631_4_COPS2-RTKN2_COPS2_chr15_49447722_ENST00000388901_RTKN2_chr10_63964781_ENST00000315289_length(amino acids)=184AA_BP=18 MSDMEDDFMCDDEEDYDLETRIRAMDKDAKKRIHNFSVINPVPGQAITQIFAVDNREDLQKWMEAFWQHFFDLSQWKHCCEELMKIEIMS PRKPPLFLTKEATSVYHDMSIDSPMKLESLTDIIQKKIEETNGQFLIGQHEESLPPPWATLFDGNHQMVIQKKNNSNQLHNLQKLPATSK -------------------------------------------------------------- >18631_18631_5_COPS2-RTKN2_COPS2_chr15_49447722_ENST00000388901_RTKN2_chr10_63964781_ENST00000373789_length(transcript)=5652nt_BP=128nt AGAGTGACGCCTCTGAGCCGCGGAGGATTGTGGGAGGAGGTTGTCTCCAATTTCTCCTCCCCCTCCCGGCCAAGATGTCTGACATGGAGG ATGATTTCATGTGCGATGATGAGGAGGACTACGACCTGGAAACCAGAATCCGGGCAATGGATAAGGATGCCAAGAAAAGAATCCATAATT TCTCTGTCATCAATCCTGTTCCTGGACAAGCTATAACTCAGATTTTTGCAGTTGACAATAGAGAAGATCTTCAGAAGTGGATGGAAGCCT TCTGGCAGCATTTCTTTGATCTTAGCCAATGGAAGCACTGTTGTGAAGAACTTATGAAAATTGAGATTATGTCACCACGGAAACCACCTT TGTTCTTGACAAAAGAGGCAACCTCAGTCTACCATGATATGAGCATTGATTCACCTATGAAACTTGAAAGTTTAACGGATATAATACAAA AAAAAATTGAAGAGACAAATGGGCAGTTCCTTATTGGTCAGCATGAAGAATCCTTACCACCTCCTTGGGCCACACTCTTTGATGGTAACC ATCAAATGGTCATCCAGAAAAAGGTACTGTATCCTGCAAGTGAGCCATTACATGATGAAAAAGGGAAAAAGAGACAAGCTCCCCTTCCTC CTTCTGATAAACTTCCATTCAGCTTAAAATCACAGAGTAACACAGATCAATTGGTTAAGGACAACTGGGGAAAAACAAGTGTATCTCAGA CATCGTCTTTGGATACCAAACTATCAACTCTAATGCATCACTTACAGAAACCAATGGCTGCTCCTCGAAAACTTCTGCCTGCCAGGAGAA ATAGATTAAGTGATGGTGAGCACACAGACACTAAAACCAATTTTGAAGCCAAGCCAGTGCCAGCTCCAAGGCAGAAATCCATCAAAGACA TTCTGGACCCTAGATCATGGCTGCAGGCACAAGTATAGAAAACTCTTAATGATAAAACATTTAACAAAATCTATAACTGTGAAGCTTAAT TCAGAGGCATTATAGAATAATGTGTAATTATATAGGTAAATATAGTGATTTATACCAATAATTAATAAGCTATTAGGTATAGAAAAACAT TTTATAATGAAGAAGTGGATTTCTCTTTTACTCCTGATTTGCAGAATGTAAGTGATTTCTCCAGCAGTGTGCAAGAGGCAGTTTCTAGAC AATATCCTAATTGTTGGAAGGGTTAATTTATTCCTGAATTAGTACCAGGCAGTGAATAAGCCCTAGGCAGAATAAAGCATTAAAATTTCT TTTGGGGAGAGACTGTCTAGTAATTTAAAATGTGTTAAATATGAACCATATTCTCATTGTGAGAATTTTAATACTAATGGAATGTTTCAA AGGTTTTATTCAAACCACAAATTATAGAATCCACCCAAGAAAATTTTCTTAGCATTCTGGAATTCTCATCTAATGGTTCACTGGCTCTCA TCTATTGTTTAACTCACTAGTTTATAGGCCTGACCTTTTAAATTCCTGGGATAAATTTTAGAATATTAAATTCTTCATCTTTAAAGGGAA TTTGTAATGTGCTATTCAAACTTGTTTCCTTGATGAGCCCTGAAATACTGTTGACATTAACTTTCATAAATGAAGCATAACACTTACTAG TTTAGAGAAATGGTAGATGAAATGCTCTTTACATTCAATTTTCTGTGTGTGGTGCTAATTTCCATTGTGACTTTGGAATTTAGGGAAGTG AGTAGCTGATCAACACCTTAAAATTCATTTAATACTTATTTAAAAAGAAGATGAGAGATTCAAAAATATCAGAAAAGTTGGCCATGGTAA ATAATTTTCAGAATTCTTTTTTAAAATTTTAATTAGATTTCCTTTTCCTAGTAAGAGTTGATGTCTGCTAGTGGTATTTTTCATTAAATG TCATATTCTTACAACAGTGACATTGGAATCATTTCCATAGGAGGTAATTTCCATAGCAACTAATCATAGTGACCCAAACAGGATTATAAA GTCAAGTGAGGAATAAATAGCAGAAAAATACCTTAAAGGAACAAAAAATCCATTTTTTATAATAATGCTTTTTGTAAACAAGAGCAGAAC AGTTTTAAAAATCTAATTAGAATTTCCAAATAAAACAGTTTCCATAAGGTGTCAGCAACAGCACTAAAAATCTCAAATCACACTGAACCC TAAATGTCATTGCAAGAAATAAAAATTTAAGAATTAAATTGCTGCCCTGTGTATAATCTCTTGAGATCTTTTTAAAGCTAGCAAGAACTC TATTTGGATCAGAACTACATTATTACAAAACAAAATGAACACTTGACCAAAAAACCACATTAATTTAAATGGAGCCTTTCATTATTTTCA GATAGCGGGGTCTTTTCCATTTATAGAGAATGATGTAACTGCCAGGACACTTTTGTGTTTGCCCAGGACTCCTAGTAAGAATTGAATCTT GAGGGAGTAATGATAACAAAAGGTTTCTTGTGACTGGTAACATCAGGACAGACAGAGTTTTTGGTGAGAAGAAAGTACTATATGCCTGCT TGATAGCATGTAGAGATCATCACATGTATGGAAACCTTAAAAAGTAAACTTATTTTTTCTAACTAGAAGGCTCTCATAAGTTTCTGTTAT GATTGCCATTTCAATAAATGACATTAAAAATCTAAAGGATATTATTGTTTGAATTTTTGGGTTATTTTTTAAAACTTCATTGCTGTTTTT GACAGCATTTGTGACTGTCATTGCCACTAAATTATTGAGCTAGAAGATGCTGCAGGGAAAATTGTTTTGAAGCTGGCATCTAAGCATTCT TTTTTTTTTCCTAGTTGATGCCTTCCTTTATTACAAATCAGTATTAAAACTTCCAGATTATATTCTTGTCATTTTTCCTCATGCAGATAA CAGCAGGAAGGACTTAAGGTGTATAAGAAAAAGAAAGTATTCATACAGAAATTACCTAGCAGTTGTGCCCTCAGAGTAGAACTTTGAAAC AGGACTGAAGCCCTTTTTACCTAGAACCATTTAAAAGCCTGAGCAAGGACCACCACCCCCTCCCCACCAAATTATTCGGTCTCTTTCTGG GGGGCCCAGCTTACTGTATGTTACAAGTCTTTGAAATGGGTCTGGTGTCTTCAGCTCCTGAAATGCTAATTTACCCCTTACCTAAGGAGT GTAGTTATAATACAGAGTTGGTTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCA TTCCCTCTGTCCGTCTCTCCTTCCCTCCTTCCCTCCTTCCTTCCTTTTTGTCTTTGTTTCTTTCTCTGGCCCCCTGTCCTCTCTCTCTGT CTCATCCCCTTTTCCCACTTTCCTTCTGTCTCTCCTTCCTCCCTTCCTTTACAGTTTAAAAAAAAAATCTAAAAATAGTTAAGCACTGTG TCAAAGAGTGTTTCAAAAGAATTGTTTGTTTTCTCATTTCTTAAACCAGAAGTTTATGACAAATAAATATGCCATGTAATATGAAAGCTG CTTCAGCTTTTTATGAGCTTTCACATTCCTTGTTTGTCCTTTTAATTTGTTTCTTGATATATGAAGACTATAAACTTGAAACAAAGAGTT AGCTGTCAGCTCTTGATAATATAATTGGGGAAACAGAATAGATATTTTATGATATGATAATTCTGATGATCTAAAGATAATGTCTTAGAC AATTACCTTTACATTTCAAGCTCTGGGATATAAATTACGTAGTCAGCATTAAGATAGTATTATTTTTAATTGCTACTAAGTGGTAACTTT TGTATTTTAATATCTTGCAAGGGCAAAGAAGGCATTTTTAAAATTCTAAATGCACACCTCCTAAGGTAAATAGTCTTTCAAAAATATCAG GCGTGCCAACTCTTGCTGAGTTTTGTTAAATCCTCCTTAACTGTCTGCAGTGCCCCCTGACTTCTTTTAAATGGATGTGAATATATGTGG AAAACTAAATCCATTTATTATAAATGCCTTATCTTTACCCTTTGGGATCTTACTAAATGCATTTTACCTGCTACTATTTATTAAAAATGG AAGCTGTCTTGAATTAGAGATACCTCACGTAAGGTAGGTTAAGCAGTCAAGTATTTCTTTAGGCTTATGTTCAGCACCTCAGCCCCCTAC TGAGAAGTTAATTAATTCAGTCCAAAATGAAATTATAGGGCAGTTTGGTGCAATTTATGTTAAATGCCATTTGAATGTAATCACCTGTGT TACCACGAATGAGGCACAACTATACTACATGGACAGAGTACTGCATTGCACCATGAGCAAGAACTGCTCTGCAAGAAAAATATCTGTCCC TGTGGTCTGAATTTATCAAAACTCATTTTCTTGTTAAAGAGTGAATTATTGAATAGTAATTAAACTTTAACTGATGACCATTTATATTCT AGTAGCCATCTTCACTGTTAGTCTTAAATTATAATGTAAAGTTGACATTTTCCCCTTACATTTCAAAGGCATCACTATTTTTAAATGTTT ACATATGTTTACATGTTTGTGTGCAACTGCTTCATTGCTATTAATAGTTAAATGAAATCTGCATATTCTGGATCATAGATGTTCTTAGTT AACTCTGGGAAAGATGTTACCTTTGGGTTTTTAAAAGACAAGTCATCATTTGAAAATATATTAGGGTGTGTTGATTTTCTGACATGCTTG TGTAATTGGCTTTGTTTATAATTTTTATTTTTTAATATGGGTCAGACTTTTGGATTAAAAAGTATTATATCATGGACATACATTTTTTAA AGTACCAAAGGTATTTGGTAAGCGAGCCCAAGTCATGTAATTGAAACTTCTGTACATTAAAAGAACTGATTCATGAAGACGTTTTCTAAC TTTTTCTCTTTAAGTGCTCCTCTAGACTAGACTGATTGAAGTAGACAGTGTGGTGGAATCAGTTTAATCAGAAAAAGACATACCAAGTAG CTGGTGCTAATTATTATAAGACTAACATTCTGATAAGCCATGGTATAATTAACATTATTAAAATGTTTACATATAATCCTTCTTAAAGTA TACTCTTTTAAAAATCCATTGACATAACCTTACTTTTAGTTTAGTGATCCAGAATTTCCCCAGAGCTTAAGCCACTGCAGTAAATTAGGT ACGTAGGATATTCAGTCGCTACTAGCCACAAGGAGTCTCCTTATTTTAATGTACCTCCCTCAGTACTTTATTCCTGCAGAGCGCCTCAGA GTGGGGGAGAGAAATGAGCAATCCTGGCTCAGTTGGATTATTTCAGCATTTTATTTCTAAATCTGTAGTGTGATCAGAAATATTTAAAAT TAAAAAAATACTTTACAGAGAGAGGCCTACTAATCAATGTGCTTAGAGAAACAAACTACCTTTACATTCAATTAACAACAAAAAAAGTTA CAGAAATTTTAACAAACATTTTTCTTTATCTGAGTATGGGAGAAAATACTAATGCTGACACGTTTAATAATTAGAAAAGATCATTCCAGA TCTTATGGAAAATTGTGTTTTAAATTCCAGCAGTTTGCTCTTGAGACATGGTAATCTCTTAATGTAACTACTAAAGGAGAGGTAGATTGA >18631_18631_5_COPS2-RTKN2_COPS2_chr15_49447722_ENST00000388901_RTKN2_chr10_63964781_ENST00000373789_length(amino acids)=287AA_BP=18 MSDMEDDFMCDDEEDYDLETRIRAMDKDAKKRIHNFSVINPVPGQAITQIFAVDNREDLQKWMEAFWQHFFDLSQWKHCCEELMKIEIMS PRKPPLFLTKEATSVYHDMSIDSPMKLESLTDIIQKKIEETNGQFLIGQHEESLPPPWATLFDGNHQMVIQKKVLYPASEPLHDEKGKKR QAPLPPSDKLPFSLKSQSNTDQLVKDNWGKTSVSQTSSLDTKLSTLMHHLQKPMAAPRKLLPARRNRLSDGEHTDTKTNFEAKPVPAPRQ -------------------------------------------------------------- >18631_18631_6_COPS2-RTKN2_COPS2_chr15_49447722_ENST00000388901_RTKN2_chr10_63964781_ENST00000395265_length(transcript)=629nt_BP=128nt AGAGTGACGCCTCTGAGCCGCGGAGGATTGTGGGAGGAGGTTGTCTCCAATTTCTCCTCCCCCTCCCGGCCAAGATGTCTGACATGGAGG ATGATTTCATGTGCGATGATGAGGAGGACTACGACCTGGAAACCAGAATCCGGGCAATGGATAAGGATGCCAAGAAAAGAATCCATAATT TCTCTGTCATCAATCCTGTTCCTGGACAAGCTATAACTCAGATTTTTGCAGTTGACAATAGAGAAGATCTTCAGAAGTGGATGGAAGCCT TCTGGCAGCATTTCTTTGATCTTAGCCAATGGAAGCACTGTTGTGAAGAACTTATGAAAATTGAGATTATGTCACCACGGAAACCACCTT TGTTCTTGACAAAAGAGGCAACCTCAGTCTACCATGATATGAGCATTGATTCACCTATGAAACTTGAAAGTTTAACGGATATAATACAAA AAAAAATTGAAGAGACAAATGGGCAGTTCCTTATTGGTCAGCATGAAGAATCCTTACCACCTCCTTGGGCCACACTCTTTGATGGTAACC >18631_18631_6_COPS2-RTKN2_COPS2_chr15_49447722_ENST00000388901_RTKN2_chr10_63964781_ENST00000395265_length(amino acids)=185AA_BP=18 MSDMEDDFMCDDEEDYDLETRIRAMDKDAKKRIHNFSVINPVPGQAITQIFAVDNREDLQKWMEAFWQHFFDLSQWKHCCEELMKIEIMS PRKPPLFLTKEATSVYHDMSIDSPMKLESLTDIIQKKIEETNGQFLIGQHEESLPPPWATLFDGNHQMVIQKKNNSNQLHNLQKLPATSK -------------------------------------------------------------- >18631_18631_7_COPS2-RTKN2_COPS2_chr15_49447722_ENST00000542928_RTKN2_chr10_63964781_ENST00000315289_length(transcript)=1868nt_BP=80nt AATTTCTCCTCCCCCTCCCGGCCAAGATGTCTGACATGGAGGATGATTTCATGTGCGATGATGAGGAGGACTACGACCTGGAAACCAGAA TCCGGGCAATGGATAAGGATGCCAAGAAAAGAATCCATAATTTCTCTGTCATCAATCCTGTTCCTGGACAAGCTATAACTCAGATTTTTG CAGTTGACAATAGAGAAGATCTTCAGAAGTGGATGGAAGCCTTCTGGCAGCATTTCTTTGATCTTAGCCAATGGAAGCACTGTTGTGAAG AACTTATGAAAATTGAGATTATGTCACCACGGAAACCACCTTTGTTCTTGACAAAAGAGGCAACCTCAGTCTACCATGATATGAGCATTG ATTCACCTATGAAACTTGAAAGTTTAACGGATATAATACAAAAAAAAATTGAAGAGACAAATGGGCAGTTCCTTATTGGTCAGCATGAAG AATCCTTACCACCTCCTTGGGCCACACTCTTTGATGGTAACCATCAAATGGTCATCCAGAAAAAGAATAATAGTAATCAACTACATAATC TCCAGAAACTGCCAGCAACTTCCAAATTCCTCTTCACATAGCTTCTCAAATACTTCATTAGAACCAGTGTGAAAAATTTAAAATACAATG TGACATTTCTCTAGTAGAATGTAAGCTTCATGAGGGAAAAGACAACGCGTCTCCTTCCTGTATTCCTAGCACCCAGTACGGCACCTGACA CATAATAGTGACCTTAGAAGAATATTTAAGAGTCATTGAGTAAACATTTTGTAGAGCTGTCCATGTTTATTTTCCATTCAGTGTTTACCA GGTGTCTGCTATTTGGACAGTCACTTCATTGTTCATTAGTACATGACTTTGGTAAATATATCTCCTGTGAAGAGAAATATTATAACTACT ATGGCATTCAACACTGGTATTTCAGTTACTCAACTAATCCACCCACTGATGGAGTGAACCTTGAATTAAATGCTTTGAAGAATAAAGTGA ATCTTGATAAAAATCAAAGGCTGAAGAAATCTTGTTTGACAGAAGGCATGAACAAAAATGCTAAAATTAATACTGTTTGTGGAGAAACAC TCATTCCACCGCAGACTAAATGGAGTTCATGAGTATCAAAATGCCTATGTGATCAAAAGGCAGAAACAGCTTCTTTTTACTAGGTCTGTT AATATTCCAGGACTCATAATATTGTGCCTACATGAGCACCTGTGTTTGTGGTAACTCAAAGTATTTGAACACCTTATCTCATCCAACCTC AAATTTCCTGTGAGGTATTTAAGCACCGAGAGCTCTTGGTACTGTTTTCAAGATGAAGCAGATGAATTAGAGAGGCTGTTCACACACCAA ATTTCACAGAAGCCTATGGAGGAAATGACGGGGAGACTTACCAGTTAACACCCAGTTGCAGAAATCAATGTCAGAGCTTGAAAGGACCTT ATAAACCCCTGATCCAATGTGGACTTTCCTAGTAAGACTTCTGTTTGCAGTGACTTGGTTCATTTCACCAACCACAAGAATTTTAAGTAA TTTTTAATCATAAAAGTAACATAGAACATAGTAATACATATATACGTACATACATGATACAGAAAGGTATCAAAAAACAAAAACATATAT TACTTCCTCCTCTAACATTCCAGTGCCAGTTTCCAAAGATTCCTATTACCCAGAGGTAACCACTGTTAATAATTTTTAATGTATATTTCC AAAAATTTTTTATGCATTTAGAAATGTGTGCATGTGGGTGATGGGTGCACCAAAATCTCAGAAATCACCACTAAAGAACTTACTCATGTA >18631_18631_7_COPS2-RTKN2_COPS2_chr15_49447722_ENST00000542928_RTKN2_chr10_63964781_ENST00000315289_length(amino acids)=184AA_BP=18 MSDMEDDFMCDDEEDYDLETRIRAMDKDAKKRIHNFSVINPVPGQAITQIFAVDNREDLQKWMEAFWQHFFDLSQWKHCCEELMKIEIMS PRKPPLFLTKEATSVYHDMSIDSPMKLESLTDIIQKKIEETNGQFLIGQHEESLPPPWATLFDGNHQMVIQKKNNSNQLHNLQKLPATSK -------------------------------------------------------------- >18631_18631_8_COPS2-RTKN2_COPS2_chr15_49447722_ENST00000542928_RTKN2_chr10_63964781_ENST00000373789_length(transcript)=5604nt_BP=80nt AATTTCTCCTCCCCCTCCCGGCCAAGATGTCTGACATGGAGGATGATTTCATGTGCGATGATGAGGAGGACTACGACCTGGAAACCAGAA TCCGGGCAATGGATAAGGATGCCAAGAAAAGAATCCATAATTTCTCTGTCATCAATCCTGTTCCTGGACAAGCTATAACTCAGATTTTTG CAGTTGACAATAGAGAAGATCTTCAGAAGTGGATGGAAGCCTTCTGGCAGCATTTCTTTGATCTTAGCCAATGGAAGCACTGTTGTGAAG AACTTATGAAAATTGAGATTATGTCACCACGGAAACCACCTTTGTTCTTGACAAAAGAGGCAACCTCAGTCTACCATGATATGAGCATTG ATTCACCTATGAAACTTGAAAGTTTAACGGATATAATACAAAAAAAAATTGAAGAGACAAATGGGCAGTTCCTTATTGGTCAGCATGAAG AATCCTTACCACCTCCTTGGGCCACACTCTTTGATGGTAACCATCAAATGGTCATCCAGAAAAAGGTACTGTATCCTGCAAGTGAGCCAT TACATGATGAAAAAGGGAAAAAGAGACAAGCTCCCCTTCCTCCTTCTGATAAACTTCCATTCAGCTTAAAATCACAGAGTAACACAGATC AATTGGTTAAGGACAACTGGGGAAAAACAAGTGTATCTCAGACATCGTCTTTGGATACCAAACTATCAACTCTAATGCATCACTTACAGA AACCAATGGCTGCTCCTCGAAAACTTCTGCCTGCCAGGAGAAATAGATTAAGTGATGGTGAGCACACAGACACTAAAACCAATTTTGAAG CCAAGCCAGTGCCAGCTCCAAGGCAGAAATCCATCAAAGACATTCTGGACCCTAGATCATGGCTGCAGGCACAAGTATAGAAAACTCTTA ATGATAAAACATTTAACAAAATCTATAACTGTGAAGCTTAATTCAGAGGCATTATAGAATAATGTGTAATTATATAGGTAAATATAGTGA TTTATACCAATAATTAATAAGCTATTAGGTATAGAAAAACATTTTATAATGAAGAAGTGGATTTCTCTTTTACTCCTGATTTGCAGAATG TAAGTGATTTCTCCAGCAGTGTGCAAGAGGCAGTTTCTAGACAATATCCTAATTGTTGGAAGGGTTAATTTATTCCTGAATTAGTACCAG GCAGTGAATAAGCCCTAGGCAGAATAAAGCATTAAAATTTCTTTTGGGGAGAGACTGTCTAGTAATTTAAAATGTGTTAAATATGAACCA TATTCTCATTGTGAGAATTTTAATACTAATGGAATGTTTCAAAGGTTTTATTCAAACCACAAATTATAGAATCCACCCAAGAAAATTTTC TTAGCATTCTGGAATTCTCATCTAATGGTTCACTGGCTCTCATCTATTGTTTAACTCACTAGTTTATAGGCCTGACCTTTTAAATTCCTG GGATAAATTTTAGAATATTAAATTCTTCATCTTTAAAGGGAATTTGTAATGTGCTATTCAAACTTGTTTCCTTGATGAGCCCTGAAATAC TGTTGACATTAACTTTCATAAATGAAGCATAACACTTACTAGTTTAGAGAAATGGTAGATGAAATGCTCTTTACATTCAATTTTCTGTGT GTGGTGCTAATTTCCATTGTGACTTTGGAATTTAGGGAAGTGAGTAGCTGATCAACACCTTAAAATTCATTTAATACTTATTTAAAAAGA AGATGAGAGATTCAAAAATATCAGAAAAGTTGGCCATGGTAAATAATTTTCAGAATTCTTTTTTAAAATTTTAATTAGATTTCCTTTTCC TAGTAAGAGTTGATGTCTGCTAGTGGTATTTTTCATTAAATGTCATATTCTTACAACAGTGACATTGGAATCATTTCCATAGGAGGTAAT TTCCATAGCAACTAATCATAGTGACCCAAACAGGATTATAAAGTCAAGTGAGGAATAAATAGCAGAAAAATACCTTAAAGGAACAAAAAA TCCATTTTTTATAATAATGCTTTTTGTAAACAAGAGCAGAACAGTTTTAAAAATCTAATTAGAATTTCCAAATAAAACAGTTTCCATAAG GTGTCAGCAACAGCACTAAAAATCTCAAATCACACTGAACCCTAAATGTCATTGCAAGAAATAAAAATTTAAGAATTAAATTGCTGCCCT GTGTATAATCTCTTGAGATCTTTTTAAAGCTAGCAAGAACTCTATTTGGATCAGAACTACATTATTACAAAACAAAATGAACACTTGACC AAAAAACCACATTAATTTAAATGGAGCCTTTCATTATTTTCAGATAGCGGGGTCTTTTCCATTTATAGAGAATGATGTAACTGCCAGGAC ACTTTTGTGTTTGCCCAGGACTCCTAGTAAGAATTGAATCTTGAGGGAGTAATGATAACAAAAGGTTTCTTGTGACTGGTAACATCAGGA CAGACAGAGTTTTTGGTGAGAAGAAAGTACTATATGCCTGCTTGATAGCATGTAGAGATCATCACATGTATGGAAACCTTAAAAAGTAAA CTTATTTTTTCTAACTAGAAGGCTCTCATAAGTTTCTGTTATGATTGCCATTTCAATAAATGACATTAAAAATCTAAAGGATATTATTGT TTGAATTTTTGGGTTATTTTTTAAAACTTCATTGCTGTTTTTGACAGCATTTGTGACTGTCATTGCCACTAAATTATTGAGCTAGAAGAT GCTGCAGGGAAAATTGTTTTGAAGCTGGCATCTAAGCATTCTTTTTTTTTTCCTAGTTGATGCCTTCCTTTATTACAAATCAGTATTAAA ACTTCCAGATTATATTCTTGTCATTTTTCCTCATGCAGATAACAGCAGGAAGGACTTAAGGTGTATAAGAAAAAGAAAGTATTCATACAG AAATTACCTAGCAGTTGTGCCCTCAGAGTAGAACTTTGAAACAGGACTGAAGCCCTTTTTACCTAGAACCATTTAAAAGCCTGAGCAAGG ACCACCACCCCCTCCCCACCAAATTATTCGGTCTCTTTCTGGGGGGCCCAGCTTACTGTATGTTACAAGTCTTTGAAATGGGTCTGGTGT CTTCAGCTCCTGAAATGCTAATTTACCCCTTACCTAAGGAGTGTAGTTATAATACAGAGTTGGTTTCCTTCCTTCCTTCCTTCCTTCCTT CCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCATTCCCTCTGTCCGTCTCTCCTTCCCTCCTTCCCTCCTTCCTTCCTTTT TGTCTTTGTTTCTTTCTCTGGCCCCCTGTCCTCTCTCTCTGTCTCATCCCCTTTTCCCACTTTCCTTCTGTCTCTCCTTCCTCCCTTCCT TTACAGTTTAAAAAAAAAATCTAAAAATAGTTAAGCACTGTGTCAAAGAGTGTTTCAAAAGAATTGTTTGTTTTCTCATTTCTTAAACCA GAAGTTTATGACAAATAAATATGCCATGTAATATGAAAGCTGCTTCAGCTTTTTATGAGCTTTCACATTCCTTGTTTGTCCTTTTAATTT GTTTCTTGATATATGAAGACTATAAACTTGAAACAAAGAGTTAGCTGTCAGCTCTTGATAATATAATTGGGGAAACAGAATAGATATTTT ATGATATGATAATTCTGATGATCTAAAGATAATGTCTTAGACAATTACCTTTACATTTCAAGCTCTGGGATATAAATTACGTAGTCAGCA TTAAGATAGTATTATTTTTAATTGCTACTAAGTGGTAACTTTTGTATTTTAATATCTTGCAAGGGCAAAGAAGGCATTTTTAAAATTCTA AATGCACACCTCCTAAGGTAAATAGTCTTTCAAAAATATCAGGCGTGCCAACTCTTGCTGAGTTTTGTTAAATCCTCCTTAACTGTCTGC AGTGCCCCCTGACTTCTTTTAAATGGATGTGAATATATGTGGAAAACTAAATCCATTTATTATAAATGCCTTATCTTTACCCTTTGGGAT CTTACTAAATGCATTTTACCTGCTACTATTTATTAAAAATGGAAGCTGTCTTGAATTAGAGATACCTCACGTAAGGTAGGTTAAGCAGTC AAGTATTTCTTTAGGCTTATGTTCAGCACCTCAGCCCCCTACTGAGAAGTTAATTAATTCAGTCCAAAATGAAATTATAGGGCAGTTTGG TGCAATTTATGTTAAATGCCATTTGAATGTAATCACCTGTGTTACCACGAATGAGGCACAACTATACTACATGGACAGAGTACTGCATTG CACCATGAGCAAGAACTGCTCTGCAAGAAAAATATCTGTCCCTGTGGTCTGAATTTATCAAAACTCATTTTCTTGTTAAAGAGTGAATTA TTGAATAGTAATTAAACTTTAACTGATGACCATTTATATTCTAGTAGCCATCTTCACTGTTAGTCTTAAATTATAATGTAAAGTTGACAT TTTCCCCTTACATTTCAAAGGCATCACTATTTTTAAATGTTTACATATGTTTACATGTTTGTGTGCAACTGCTTCATTGCTATTAATAGT TAAATGAAATCTGCATATTCTGGATCATAGATGTTCTTAGTTAACTCTGGGAAAGATGTTACCTTTGGGTTTTTAAAAGACAAGTCATCA TTTGAAAATATATTAGGGTGTGTTGATTTTCTGACATGCTTGTGTAATTGGCTTTGTTTATAATTTTTATTTTTTAATATGGGTCAGACT TTTGGATTAAAAAGTATTATATCATGGACATACATTTTTTAAAGTACCAAAGGTATTTGGTAAGCGAGCCCAAGTCATGTAATTGAAACT TCTGTACATTAAAAGAACTGATTCATGAAGACGTTTTCTAACTTTTTCTCTTTAAGTGCTCCTCTAGACTAGACTGATTGAAGTAGACAG TGTGGTGGAATCAGTTTAATCAGAAAAAGACATACCAAGTAGCTGGTGCTAATTATTATAAGACTAACATTCTGATAAGCCATGGTATAA TTAACATTATTAAAATGTTTACATATAATCCTTCTTAAAGTATACTCTTTTAAAAATCCATTGACATAACCTTACTTTTAGTTTAGTGAT CCAGAATTTCCCCAGAGCTTAAGCCACTGCAGTAAATTAGGTACGTAGGATATTCAGTCGCTACTAGCCACAAGGAGTCTCCTTATTTTA ATGTACCTCCCTCAGTACTTTATTCCTGCAGAGCGCCTCAGAGTGGGGGAGAGAAATGAGCAATCCTGGCTCAGTTGGATTATTTCAGCA TTTTATTTCTAAATCTGTAGTGTGATCAGAAATATTTAAAATTAAAAAAATACTTTACAGAGAGAGGCCTACTAATCAATGTGCTTAGAG AAACAAACTACCTTTACATTCAATTAACAACAAAAAAAGTTACAGAAATTTTAACAAACATTTTTCTTTATCTGAGTATGGGAGAAAATA CTAATGCTGACACGTTTAATAATTAGAAAAGATCATTCCAGATCTTATGGAAAATTGTGTTTTAAATTCCAGCAGTTTGCTCTTGAGACA TGGTAATCTCTTAATGTAACTACTAAAGGAGAGGTAGATTGAAAAGATCTTGTATATACATAATTATGTCAGATGGTTCAAGATATCAAA >18631_18631_8_COPS2-RTKN2_COPS2_chr15_49447722_ENST00000542928_RTKN2_chr10_63964781_ENST00000373789_length(amino acids)=287AA_BP=18 MSDMEDDFMCDDEEDYDLETRIRAMDKDAKKRIHNFSVINPVPGQAITQIFAVDNREDLQKWMEAFWQHFFDLSQWKHCCEELMKIEIMS PRKPPLFLTKEATSVYHDMSIDSPMKLESLTDIIQKKIEETNGQFLIGQHEESLPPPWATLFDGNHQMVIQKKVLYPASEPLHDEKGKKR QAPLPPSDKLPFSLKSQSNTDQLVKDNWGKTSVSQTSSLDTKLSTLMHHLQKPMAAPRKLLPARRNRLSDGEHTDTKTNFEAKPVPAPRQ -------------------------------------------------------------- >18631_18631_9_COPS2-RTKN2_COPS2_chr15_49447722_ENST00000542928_RTKN2_chr10_63964781_ENST00000395265_length(transcript)=581nt_BP=80nt AATTTCTCCTCCCCCTCCCGGCCAAGATGTCTGACATGGAGGATGATTTCATGTGCGATGATGAGGAGGACTACGACCTGGAAACCAGAA TCCGGGCAATGGATAAGGATGCCAAGAAAAGAATCCATAATTTCTCTGTCATCAATCCTGTTCCTGGACAAGCTATAACTCAGATTTTTG CAGTTGACAATAGAGAAGATCTTCAGAAGTGGATGGAAGCCTTCTGGCAGCATTTCTTTGATCTTAGCCAATGGAAGCACTGTTGTGAAG AACTTATGAAAATTGAGATTATGTCACCACGGAAACCACCTTTGTTCTTGACAAAAGAGGCAACCTCAGTCTACCATGATATGAGCATTG ATTCACCTATGAAACTTGAAAGTTTAACGGATATAATACAAAAAAAAATTGAAGAGACAAATGGGCAGTTCCTTATTGGTCAGCATGAAG AATCCTTACCACCTCCTTGGGCCACACTCTTTGATGGTAACCATCAAATGGTCATCCAGAAAAAGAATAATAGTAATCAACTACATAATC >18631_18631_9_COPS2-RTKN2_COPS2_chr15_49447722_ENST00000542928_RTKN2_chr10_63964781_ENST00000395265_length(amino acids)=185AA_BP=18 MSDMEDDFMCDDEEDYDLETRIRAMDKDAKKRIHNFSVINPVPGQAITQIFAVDNREDLQKWMEAFWQHFFDLSQWKHCCEELMKIEIMS PRKPPLFLTKEATSVYHDMSIDSPMKLESLTDIIQKKIEETNGQFLIGQHEESLPPPWATLFDGNHQMVIQKKNNSNQLHNLQKLPATSK -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for COPS2-RTKN2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for COPS2-RTKN2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for COPS2-RTKN2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | COPS2 | C0014175 | Endometriosis | 1 | CTD_human |
| Hgene | COPS2 | C0269102 | Endometrioma | 1 | CTD_human |
| Tgene | C0036341 | Schizophrenia | 1 | PSYGENET |
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