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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:COX5A-FAM72A (FusionGDB2 ID:HG9377TG729533) |
Fusion Gene Summary for COX5A-FAM72A |
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Fusion gene information | Fusion gene name: COX5A-FAM72A | Fusion gene ID: hg9377tg729533 | Hgene | Tgene | Gene symbol | COX5A | FAM72A | Gene ID | 9377 | 729533 |
Gene name | cytochrome c oxidase subunit 5A | family with sequence similarity 72 member A | |
Synonyms | COX|COX-VA|VA | LMPIP|Ugene|p17 | |
Cytomap | ('COX5A')('FAM72A') 15q24.2 | 1q32.1 | |
Type of gene | protein-coding | protein-coding | |
Description | cytochrome c oxidase subunit 5A, mitochondrialcytochrome c oxidase polypeptide Vacytochrome c oxidase polypeptide, mitochondrialcytochrome c oxidase subunit Vamitochondrial cytochrome c oxidase subunit Va | protein FAM72ALMP1-induced proteinlatent membrane protein 1-induced protein | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | P20674 | . | |
Ensembl transtripts involved in fusion gene | ENST00000322347, ENST00000567270, ENST00000568517, ENST00000562233, ENST00000564811, ENST00000568783, | ||
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 3 X 3 X 3=27 |
# samples | 3 | 3 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: COX5A [Title/Abstract] AND FAM72A [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | COX5A(75215989)-FAM72A(206153957), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-HU-A4GT-01A | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
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Fusion Gene ORF analysis for COX5A-FAM72A |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000322347 | ENST00000470041 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
3UTR-3UTR | ENST00000567270 | ENST00000470041 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
3UTR-3UTR | ENST00000568517 | ENST00000470041 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
3UTR-intron | ENST00000322347 | ENST00000341209 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
3UTR-intron | ENST00000322347 | ENST00000367128 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
3UTR-intron | ENST00000322347 | ENST00000367129 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
3UTR-intron | ENST00000322347 | ENST00000468509 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
3UTR-intron | ENST00000322347 | ENST00000607379 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
3UTR-intron | ENST00000567270 | ENST00000341209 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
3UTR-intron | ENST00000567270 | ENST00000367128 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
3UTR-intron | ENST00000567270 | ENST00000367129 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
3UTR-intron | ENST00000567270 | ENST00000468509 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
3UTR-intron | ENST00000567270 | ENST00000607379 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
3UTR-intron | ENST00000568517 | ENST00000341209 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
3UTR-intron | ENST00000568517 | ENST00000367128 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
3UTR-intron | ENST00000568517 | ENST00000367129 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
3UTR-intron | ENST00000568517 | ENST00000468509 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
3UTR-intron | ENST00000568517 | ENST00000607379 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
intron-3UTR | ENST00000562233 | ENST00000470041 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
intron-3UTR | ENST00000564811 | ENST00000470041 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
intron-3UTR | ENST00000568783 | ENST00000470041 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
intron-intron | ENST00000562233 | ENST00000341209 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
intron-intron | ENST00000562233 | ENST00000367128 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
intron-intron | ENST00000562233 | ENST00000367129 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
intron-intron | ENST00000562233 | ENST00000468509 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
intron-intron | ENST00000562233 | ENST00000607379 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
intron-intron | ENST00000564811 | ENST00000341209 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
intron-intron | ENST00000564811 | ENST00000367128 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
intron-intron | ENST00000564811 | ENST00000367129 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
intron-intron | ENST00000564811 | ENST00000468509 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
intron-intron | ENST00000564811 | ENST00000607379 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
intron-intron | ENST00000568783 | ENST00000341209 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
intron-intron | ENST00000568783 | ENST00000367128 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
intron-intron | ENST00000568783 | ENST00000367129 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
intron-intron | ENST00000568783 | ENST00000468509 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
intron-intron | ENST00000568783 | ENST00000607379 | COX5A | chr15 | 75215989 | - | FAM72A | chr1 | 206153957 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for COX5A-FAM72A |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
COX5A | chr15 | 75215988 | - | FAM72A | chr1 | 206153956 | + | 3.08E-06 | 0.9999969 |
COX5A | chr15 | 75215988 | - | FAM72A | chr1 | 206153956 | + | 3.08E-06 | 0.9999969 |
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Fusion Protein Features for COX5A-FAM72A |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:75215989/:206153957) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
COX5A | . |
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00427}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for COX5A-FAM72A |
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Fusion Gene PPI Analysis for COX5A-FAM72A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for COX5A-FAM72A |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | COX5A | P20674 | DB02659 | Cholic Acid | Small molecule | Approved |
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Related Diseases for COX5A-FAM72A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | COX5A | C0268237 | Cytochrome-c Oxidase Deficiency | 1 | ORPHANET |