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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LIPG-UCMA (FusionGDB2 ID:HG9388TG221044)

Fusion Gene Summary for LIPG-UCMA

check button Fusion gene summary
Fusion gene informationFusion gene name: LIPG-UCMA
Fusion gene ID: hg9388tg221044
HgeneTgene
Gene symbol

LIPG

UCMA

Gene ID

9388

221044

Gene namelipase G, endothelial typeupper zone of growth plate and cartilage matrix associated
SynonymsEDL|EL|PRO719C10orf49|GRP|GRP/UCMA
Cytomap('LIPG')('UCMA')

18q21.1

10p13

Type of geneprotein-codingprotein-coding
Descriptionendothelial lipaseendothelial cell-derived lipaselipase, endotheliallipoprotein lipase Hunique cartilage matrix-associated proteinGla-rich protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000261292, ENST00000427224, 
ENST00000577628, ENST00000580036, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 3=27
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LIPG [Title/Abstract] AND UCMA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLIPG(47095918)-UCMA(13275800), # samples:3
Anticipated loss of major functional domain due to fusion event.LIPG-UCMA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LIPG-UCMA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LIPG-UCMA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LIPG-UCMA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLIPG

GO:0032376

positive regulation of cholesterol transport

19136670


check buttonFusion gene breakpoints across LIPG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across UCMA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-ZF-AA4T-01ALIPGchr18

47095918

-UCMAchr10

13275800

-
ChimerDB4BLCATCGA-ZF-AA4T-01ALIPGchr18

47095918

+UCMAchr10

13275800

-


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Fusion Gene ORF analysis for LIPG-UCMA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000261292ENST00000463405LIPGchr18

47095918

+UCMAchr10

13275800

-
5CDS-intronENST00000427224ENST00000463405LIPGchr18

47095918

+UCMAchr10

13275800

-
5CDS-intronENST00000577628ENST00000463405LIPGchr18

47095918

+UCMAchr10

13275800

-
5CDS-intronENST00000580036ENST00000463405LIPGchr18

47095918

+UCMAchr10

13275800

-
In-frameENST00000261292ENST00000378681LIPGchr18

47095918

+UCMAchr10

13275800

-
In-frameENST00000427224ENST00000378681LIPGchr18

47095918

+UCMAchr10

13275800

-
In-frameENST00000577628ENST00000378681LIPGchr18

47095918

+UCMAchr10

13275800

-
In-frameENST00000580036ENST00000378681LIPGchr18

47095918

+UCMAchr10

13275800

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000577628LIPGchr1847095918+ENST00000378681UCMAchr1013275800-236116669782024348
ENST00000261292LIPGchr1847095918+ENST00000378681UCMAchr1013275800-1544849381207389
ENST00000427224LIPGchr1847095918+ENST00000378681UCMAchr1013275800-151582091178389
ENST00000580036LIPGchr1847095918+ENST00000378681UCMAchr1013275800-1488793331151372

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000577628ENST00000378681LIPGchr1847095918+UCMAchr1013275800-0.0036926180.9963074
ENST00000261292ENST00000378681LIPGchr1847095918+UCMAchr1013275800-0.0040954320.9959046
ENST00000427224ENST00000378681LIPGchr1847095918+UCMAchr1013275800-0.0041349480.9958651
ENST00000580036ENST00000378681LIPGchr1847095918+UCMAchr1013275800-0.0041755050.99582446

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Fusion Genomic Features for LIPG-UCMA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for LIPG-UCMA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:47095918/chr10:13275800)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLIPGchr18:47095918chr10:13275800ENST00000261292+410118_121190501.0Compositional biasNote=Poly-Val
HgeneLIPGchr18:47095918chr10:13275800ENST00000580036+46118_121190355.0Compositional biasNote=Poly-Val
TgeneUCMAchr18:47095918chr10:13275800ENST000003786810590_12219139.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLIPGchr18:47095918chr10:13275800ENST00000261292+410347_482190501.0DomainPLAT
HgeneLIPGchr18:47095918chr10:13275800ENST00000580036+46347_482190355.0DomainPLAT
HgeneLIPGchr18:47095918chr10:13275800ENST00000261292+410325_337190501.0RegionHeparin-binding
HgeneLIPGchr18:47095918chr10:13275800ENST00000580036+46325_337190355.0RegionHeparin-binding


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Fusion Gene Sequence for LIPG-UCMA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>45654_45654_1_LIPG-UCMA_LIPG_chr18_47095918_ENST00000261292_UCMA_chr10_13275800_ENST00000378681_length(transcript)=1544nt_BP=849nt
AAAAACTACCTCTATAGGAGCGTGACAGCAGCGAGTCCTTGCCTCCCGGCGGCTCAGGACGAGGGCAGATCTCGTTCTGGGGCAAGCCGT
TGACACTCGCTCCCTGCCACCGCCCGGGCTCCGTGCCGCCAAGTTTTCATTTTCCACCTTCTCTGCCTCCAGTCCCCCAGCCCCTGGCCG
AGAGAAGGGTCTTACCGGCCGGGATTGCTGGAAACACCAAGAGGTGGTTTTTGTTTTTTAAAACTTCTGTTTCTTGGGAGGGGGTGTGGC
GGGGCAGGATGAGCAACTCCGTTCCTCTGCTCTGTTTCTGGAGCCTCTGCTATTGCTTTGCTGCGGGGAGCCCCGTACCTTTTGGTCCAG
AGGGACGGCTGGAAGATAAGCTCCACAAACCCAAAGCTACACAGACTGAGGTCAAACCATCTGTGAGGTTTAACCTCCGCACCTCCAAGG
ACCCAGAGCATGAAGGATGCTACCTCTCCGTCGGCCACAGCCAGCCCTTAGAAGACTGCAGTTTCAACATGACAGCTAAAACCTTTTTCA
TCATTCACGGATGGACGATGAGCGGTATCTTTGAAAACTGGCTGCACAAACTCGTGTCAGCCCTGCACACAAGAGAGAAAGACGCCAATG
TAGTTGTGGTTGACTGGCTCCCCCTGGCCCACCAGCTTTACACGGATGCGGTCAATAATACCAGGGTGGTGGGACACAGCATTGCCAGGA
TGCTCGACTGGCTGCAGGAGAAGGACGATTTTTCTCTCGGGAATGTCCACTTGATCGGCTACAGCCTCGGAGCGCACGTGGCCGGGTATG
CAGGCAACTTCGTGAAAGGAACGGTGGGCCGAATCACAGTGCTGAGAGAGGGAACCAGTGTATCTGTGGGCACCATGCAGATGGCGGGAG
AAGAGGCGAGTGAAGATGCAAAACAGAAGATTTTCATGCAGGAATCAGATGCCTCGAATTTCCTCAAGAGGCGCGGCAAGCGGTCCCCCA
AGTCCAGAGATGAGGTCAATGTGGAAAACAGGCAGAAGCTTCGGGTTGATGAGCTGCGGAGAGAATATTACGAGGAACAAAGGAATGAAT
TTGAGAACTTCGTGGAGGAACAAAACGATGAGCAGGAAGAGAGGAGCCGGGAGGCTGTGGAGCAGTGGCGCCAGTGGCACTATGACGGCC
TGCACCCATCCTATCTCTACAACCGCCACCACACCTGATCCCATCCTGAAGCCGGCCAAGAAGACAAAGCTTGTAGCACCATTGGCATCC
CCGTGTTCCAGCAATCTTTCCCATGCAAACCGGCCCTTCAGAGGGTCTCAGCTTGGGGTCTGCAGTGGCCAGCAGCTCTTGAAAAGACGC
ATGCCTTTCCTTCCAGTGTGTGAAAGTGTCCTGACTTTCACCTCTTTGCAGACCATCTTCTGAGGTGAGCAACTGCCTGCAGGGCCTCCT
AGTACCAAACCTACAGTGGCTTCCCCTGGCTTCGTTCCCAAGCAAAAGAATCAGTCAAGAATCACATGTTTGCTTATGGCTTACAAATAA
AAACGCTGAATCAA

>45654_45654_1_LIPG-UCMA_LIPG_chr18_47095918_ENST00000261292_UCMA_chr10_13275800_ENST00000378681_length(amino acids)=389AA_BP=270
MPPGGSGRGQISFWGKPLTLAPCHRPGSVPPSFHFPPSLPPVPQPLAERRVLPAGIAGNTKRWFLFFKTSVSWEGVWRGRMSNSVPLLCF
WSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFEN
WLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRIT
VLREGTSVSVGTMQMAGEEASEDAKQKIFMQESDASNFLKRRGKRSPKSRDEVNVENRQKLRVDELRREYYEEQRNEFENFVEEQNDEQE
ERSREAVEQWRQWHYDGLHPSYLYNRHHT

--------------------------------------------------------------
>45654_45654_2_LIPG-UCMA_LIPG_chr18_47095918_ENST00000427224_UCMA_chr10_13275800_ENST00000378681_length(transcript)=1515nt_BP=820nt
AGCGAGTCCTTGCCTCCCGGCGGCTCAGGACGAGGGCAGATCTCGTTCTGGGGCAAGCCGTTGACACTCGCTCCCTGCCACCGCCCGGGC
TCCGTGCCGCCAAGTTTTCATTTTCCACCTTCTCTGCCTCCAGTCCCCCAGCCCCTGGCCGAGAGAAGGGTCTTACCGGCCGGGATTGCT
GGAAACACCAAGAGGTGGTTTTTGTTTTTTAAAACTTCTGTTTCTTGGGAGGGGGTGTGGCGGGGCAGGATGAGCAACTCCGTTCCTCTG
CTCTGTTTCTGGAGCCTCTGCTATTGCTTTGCTGCGGGGAGCCCCGTACCTTTTGGTCCAGAGGGACGGCTGGAAGATAAGCTCCACAAA
CCCAAAGCTACACAGACTGAGGTCAAACCATCTGTGAGGTTTAACCTCCGCACCTCCAAGGACCCAGAGCATGAAGGATGCTACCTCTCC
GTCGGCCACAGCCAGCCCTTAGAAGACTGCAGTTTCAACATGACAGCTAAAACCTTTTTCATCATTCACGGATGGACGATGAGCGGTATC
TTTGAAAACTGGCTGCACAAACTCGTGTCAGCCCTGCACACAAGAGAGAAAGACGCCAATGTAGTTGTGGTTGACTGGCTCCCCCTGGCC
CACCAGCTTTACACGGATGCGGTCAATAATACCAGGGTGGTGGGACACAGCATTGCCAGGATGCTCGACTGGCTGCAGGAGAAGGACGAT
TTTTCTCTCGGGAATGTCCACTTGATCGGCTACAGCCTCGGAGCGCACGTGGCCGGGTATGCAGGCAACTTCGTGAAAGGAACGGTGGGC
CGAATCACAGTGCTGAGAGAGGGAACCAGTGTATCTGTGGGCACCATGCAGATGGCGGGAGAAGAGGCGAGTGAAGATGCAAAACAGAAG
ATTTTCATGCAGGAATCAGATGCCTCGAATTTCCTCAAGAGGCGCGGCAAGCGGTCCCCCAAGTCCAGAGATGAGGTCAATGTGGAAAAC
AGGCAGAAGCTTCGGGTTGATGAGCTGCGGAGAGAATATTACGAGGAACAAAGGAATGAATTTGAGAACTTCGTGGAGGAACAAAACGAT
GAGCAGGAAGAGAGGAGCCGGGAGGCTGTGGAGCAGTGGCGCCAGTGGCACTATGACGGCCTGCACCCATCCTATCTCTACAACCGCCAC
CACACCTGATCCCATCCTGAAGCCGGCCAAGAAGACAAAGCTTGTAGCACCATTGGCATCCCCGTGTTCCAGCAATCTTTCCCATGCAAA
CCGGCCCTTCAGAGGGTCTCAGCTTGGGGTCTGCAGTGGCCAGCAGCTCTTGAAAAGACGCATGCCTTTCCTTCCAGTGTGTGAAAGTGT
CCTGACTTTCACCTCTTTGCAGACCATCTTCTGAGGTGAGCAACTGCCTGCAGGGCCTCCTAGTACCAAACCTACAGTGGCTTCCCCTGG
CTTCGTTCCCAAGCAAAAGAATCAGTCAAGAATCACATGTTTGCTTATGGCTTACAAATAAAAACGCTGAATCAA

>45654_45654_2_LIPG-UCMA_LIPG_chr18_47095918_ENST00000427224_UCMA_chr10_13275800_ENST00000378681_length(amino acids)=389AA_BP=270
MPPGGSGRGQISFWGKPLTLAPCHRPGSVPPSFHFPPSLPPVPQPLAERRVLPAGIAGNTKRWFLFFKTSVSWEGVWRGRMSNSVPLLCF
WSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFEN
WLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRIT
VLREGTSVSVGTMQMAGEEASEDAKQKIFMQESDASNFLKRRGKRSPKSRDEVNVENRQKLRVDELRREYYEEQRNEFENFVEEQNDEQE
ERSREAVEQWRQWHYDGLHPSYLYNRHHT

--------------------------------------------------------------
>45654_45654_3_LIPG-UCMA_LIPG_chr18_47095918_ENST00000577628_UCMA_chr10_13275800_ENST00000378681_length(transcript)=2361nt_BP=1666nt
AATGAGGCGAGGTCGGAACAGGATCTGCTGGCTCCGGCTCGGTTTCCTCGCACAGGTCTCTCCAGCTGGATCCTCGACGCTAGGGAGGAA
GGGGCGCGGGACTGCTGTGGGGGTTTTCCCTCCCCAGGCAGGGGCAGGACCTGTTCCGGGCGACTGCAGGGTTAAGGGTATCGTCTTAAA
GAGCCGGATCCTCCCGGCTGGAGCGAGGCTGGATGGCGGGACGCAGCCTCTCAGCCTCTCGTACCCGCCCTGCGTCCGCAGTGGTTGTTG
GCGCAGCCGCCCCGTCGGTGTTCCGGGCTCAGTCCCCGCTCCCCAGCGCCAGACGCAGACTCCGGGCCAAGTTCTCCCTCCGCTCGCTGC
TTTCTGCCGCAGGACCCGGATCAATAAAGGGAAGGAGAGCCGGGAGGAAATGATGGAGAACAGAGAGAAAGGAGATGCTTGATTTCACTC
GCCAAGGAGTGAGTGCTCATCGGCAGACACTGGGCTCTGGCCACGCGTCTTAGACTCCAAATCTCGGCTCACTGGTCCCTTTGAGGAGGT
CGCCTGGTGTTCCCGTAGCCCTCCACCCCACCGTAGGAGAGCGCCTGCCACGAGCTCCGCGCCTCGCTAAGTGCTTTGCTACGTGAACTC
TTAGTTTTCCCAACATCCCTAAGCCGCCGATACATTATCACCCACGTATTGCGGACGAGAGAACCGCCTCGGAGAAGCTGGCTGGCTCGC
TTGGAGTTTTGCAGCTAGTGGCGGAGCGAGCATTCCGAGCAGGTACTGTGCGATCCTCCAGCGCCGGCCGCAGCTCACAGCCCCTTAGCT
CCGCCGGGTTATTGTGCGGCCGCGCCTTCTGCACCTGTTGCGGCCCTCGCTAGGCGGGAAGGGAGGGAGAAGAGGAGGACAAAGGGGATG
ACCAGGTGGCTCTCCCCCGACGGACTCCCGGCCCAGGGAGCGGATAGACCACTCCCAGAGAGAGTGTGGCTTTGAGCCTTGGAGAGGATG
CTCTCCTTCTCCAGGGATCGCCTCCCCAGCGGACGCAGAGTTTCAGGGAAATGTCCGCCTCCGCCACTTGGGATGGCAGTGGGGAGAGGA
GGATCTGGGTGTCCGGAGGAGGGCAGTGGGAGAAAGCTGGAGCTGCTGGAGTCGCAGCTGCCTGCGGAGCGGGCCCGGGAGGAAGCGGGG
CCGAGCGTGCGGCGTCCACGCGATAAGCTCCACAAACCCAAAGCTACACAGACTGAGGTCAAACCATCTGTGAGGTTTAACCTCCGCACC
TCCAAGGACCCAGAGCATGAAGGATGCTACCTCTCCGTCGGCCACAGCCAGCCCTTAGAAGACTGCAGTTTCAACATGACAGCTAAAACC
TTTTTCATCATTCACGGATGGACGATGAGCGGTATCTTTGAAAACTGGCTGCACAAACTCGTGTCAGCCCTGCACACAAGAGAGAAAGAC
GCCAATGTAGTTGTGGTTGACTGGCTCCCCCTGGCCCACCAGCTTTACACGGATGCGGTCAATAATACCAGGGTGGTGGGACACAGCATT
GCCAGGATGCTCGACTGGCTGCAGGAGAAGGACGATTTTTCTCTCGGGAATGTCCACTTGATCGGCTACAGCCTCGGAGCGCACGTGGCC
GGGTATGCAGGCAACTTCGTGAAAGGAACGGTGGGCCGAATCACAGTGCTGAGAGAGGGAACCAGTGTATCTGTGGGCACCATGCAGATG
GCGGGAGAAGAGGCGAGTGAAGATGCAAAACAGAAGATTTTCATGCAGGAATCAGATGCCTCGAATTTCCTCAAGAGGCGCGGCAAGCGG
TCCCCCAAGTCCAGAGATGAGGTCAATGTGGAAAACAGGCAGAAGCTTCGGGTTGATGAGCTGCGGAGAGAATATTACGAGGAACAAAGG
AATGAATTTGAGAACTTCGTGGAGGAACAAAACGATGAGCAGGAAGAGAGGAGCCGGGAGGCTGTGGAGCAGTGGCGCCAGTGGCACTAT
GACGGCCTGCACCCATCCTATCTCTACAACCGCCACCACACCTGATCCCATCCTGAAGCCGGCCAAGAAGACAAAGCTTGTAGCACCATT
GGCATCCCCGTGTTCCAGCAATCTTTCCCATGCAAACCGGCCCTTCAGAGGGTCTCAGCTTGGGGTCTGCAGTGGCCAGCAGCTCTTGAA
AAGACGCATGCCTTTCCTTCCAGTGTGTGAAAGTGTCCTGACTTTCACCTCTTTGCAGACCATCTTCTGAGGTGAGCAACTGCCTGCAGG
GCCTCCTAGTACCAAACCTACAGTGGCTTCCCCTGGCTTCGTTCCCAAGCAAAAGAATCAGTCAAGAATCACATGTTTGCTTATGGCTTA
CAAATAAAAACGCTGAATCAA

>45654_45654_3_LIPG-UCMA_LIPG_chr18_47095918_ENST00000577628_UCMA_chr10_13275800_ENST00000378681_length(amino acids)=348AA_BP=229
MERMLSFSRDRLPSGRRVSGKCPPPPLGMAVGRGGSGCPEEGSGRKLELLESQLPAERAREEAGPSVRRPRDKLHKPKATQTEVKPSVRF
NLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVV
GHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITVLREGTSVSVGTMQMAGEEASEDAKQKIFMQESDASNFLKR
RGKRSPKSRDEVNVENRQKLRVDELRREYYEEQRNEFENFVEEQNDEQEERSREAVEQWRQWHYDGLHPSYLYNRHHT

--------------------------------------------------------------
>45654_45654_4_LIPG-UCMA_LIPG_chr18_47095918_ENST00000580036_UCMA_chr10_13275800_ENST00000378681_length(transcript)=1488nt_BP=793nt
GGACGAGGGCAGATCTCGTTCTGGGGCAAGCCGTTGACACTCGCTCCCTGCCACCGCCCGGGCTCCGTGCCGCCAAGTTTTCATTTTCCA
CCTTCTCTGCCTCCAGTCCCCCAGCCCCTGGCCGAGAGAAGGGTCTTACCGGCCGGGATTGCTGGAAACACCAAGAGGTGGTTTTTGTTT
TTTAAAACTTCTGTTTCTTGGGAGGGGGTGTGGCGGGGCAGGATGAGCAACTCCGTTCCTCTGCTCTGTTTCTGGAGCCTCTGCTATTGC
TTTGCTGCGGGGAGCCCCGTACCTTTTGGTCCAGAGGGACGGCTGGAAGATAAGCTCCACAAACCCAAAGCTACACAGACTGAGGTCAAA
CCATCTGTGAGGTTTAACCTCCGCACCTCCAAGGACCCAGAGCATGAAGGATGCTACCTCTCCGTCGGCCACAGCCAGCCCTTAGAAGAC
TGCAGTTTCAACATGACAGCTAAAACCTTTTTCATCATTCACGGATGGACGATGAGCGGTATCTTTGAAAACTGGCTGCACAAACTCGTG
TCAGCCCTGCACACAAGAGAGAAAGACGCCAATGTAGTTGTGGTTGACTGGCTCCCCCTGGCCCACCAGCTTTACACGGATGCGGTCAAT
AATACCAGGGTGGTGGGACACAGCATTGCCAGGATGCTCGACTGGCTGCAGGAGAAGGACGATTTTTCTCTCGGGAATGTCCACTTGATC
GGCTACAGCCTCGGAGCGCACGTGGCCGGGTATGCAGGCAACTTCGTGAAAGGAACGGTGGGCCGAATCACAGTGCTGAGAGAGGGAACC
AGTGTATCTGTGGGCACCATGCAGATGGCGGGAGAAGAGGCGAGTGAAGATGCAAAACAGAAGATTTTCATGCAGGAATCAGATGCCTCG
AATTTCCTCAAGAGGCGCGGCAAGCGGTCCCCCAAGTCCAGAGATGAGGTCAATGTGGAAAACAGGCAGAAGCTTCGGGTTGATGAGCTG
CGGAGAGAATATTACGAGGAACAAAGGAATGAATTTGAGAACTTCGTGGAGGAACAAAACGATGAGCAGGAAGAGAGGAGCCGGGAGGCT
GTGGAGCAGTGGCGCCAGTGGCACTATGACGGCCTGCACCCATCCTATCTCTACAACCGCCACCACACCTGATCCCATCCTGAAGCCGGC
CAAGAAGACAAAGCTTGTAGCACCATTGGCATCCCCGTGTTCCAGCAATCTTTCCCATGCAAACCGGCCCTTCAGAGGGTCTCAGCTTGG
GGTCTGCAGTGGCCAGCAGCTCTTGAAAAGACGCATGCCTTTCCTTCCAGTGTGTGAAAGTGTCCTGACTTTCACCTCTTTGCAGACCAT
CTTCTGAGGTGAGCAACTGCCTGCAGGGCCTCCTAGTACCAAACCTACAGTGGCTTCCCCTGGCTTCGTTCCCAAGCAAAAGAATCAGTC
AAGAATCACATGTTTGCTTATGGCTTACAAATAAAAACGCTGAATCAA

>45654_45654_4_LIPG-UCMA_LIPG_chr18_47095918_ENST00000580036_UCMA_chr10_13275800_ENST00000378681_length(amino acids)=372AA_BP=253
MTLAPCHRPGSVPPSFHFPPSLPPVPQPLAERRVLPAGIAGNTKRWFLFFKTSVSWEGVWRGRMSNSVPLLCFWSLCYCFAAGSPVPFGP
EGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDAN
VVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITVLREGTSVSVGTMQMAG
EEASEDAKQKIFMQESDASNFLKRRGKRSPKSRDEVNVENRQKLRVDELRREYYEEQRNEFENFVEEQNDEQEERSREAVEQWRQWHYDG
LHPSYLYNRHHT

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Fusion Gene PPI Analysis for LIPG-UCMA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LIPG-UCMA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LIPG-UCMA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource