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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP12-SORCS3 (FusionGDB2 ID:HG94134TG22986)

Fusion Gene Summary for ARHGAP12-SORCS3

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP12-SORCS3
Fusion gene ID: hg94134tg22986
HgeneTgene
Gene symbol

ARHGAP12

SORCS3

Gene ID

94134

22986

Gene nameRho GTPase activating protein 12sortilin related VPS10 domain containing receptor 3
Synonyms-SORCS
Cytomap('ARHGAP12')('SORCS3')

10p11.22

10q25.1

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 12rho-type GTPase-activating protein 12VPS10 domain-containing receptor SorCS3VPS10 domain receptor protein SORCS 3 (SORCS3)
Modification date2020031320200313
UniProtAcc

Q8IWW6

.
Ensembl transtripts involved in fusion geneENST00000311380, ENST00000344936, 
ENST00000375245, ENST00000375250, 
ENST00000396144, ENST00000492028, 
Fusion gene scores* DoF score9 X 8 X 7=5043 X 3 X 2=18
# samples 113
** MAII scorelog2(11/504*10)=-2.19592020997526
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARHGAP12 [Title/Abstract] AND SORCS3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP12(32197100)-SORCS3(106916896), # samples:1
Anticipated loss of major functional domain due to fusion event.ARHGAP12-SORCS3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP12-SORCS3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP12-SORCS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP12-SORCS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARHGAP12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SORCS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CN-4727-01AARHGAP12chr10

32197100

-SORCS3chr10

106916896

+


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Fusion Gene ORF analysis for ARHGAP12-SORCS3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000311380ENST00000369699ARHGAP12chr10

32197100

-SORCS3chr10

106916896

+
5CDS-intronENST00000344936ENST00000369699ARHGAP12chr10

32197100

-SORCS3chr10

106916896

+
5CDS-intronENST00000375245ENST00000369699ARHGAP12chr10

32197100

-SORCS3chr10

106916896

+
5CDS-intronENST00000375250ENST00000369699ARHGAP12chr10

32197100

-SORCS3chr10

106916896

+
5CDS-intronENST00000396144ENST00000369699ARHGAP12chr10

32197100

-SORCS3chr10

106916896

+
Frame-shiftENST00000344936ENST00000369701ARHGAP12chr10

32197100

-SORCS3chr10

106916896

+
Frame-shiftENST00000375245ENST00000369701ARHGAP12chr10

32197100

-SORCS3chr10

106916896

+
Frame-shiftENST00000375250ENST00000369701ARHGAP12chr10

32197100

-SORCS3chr10

106916896

+
Frame-shiftENST00000396144ENST00000369701ARHGAP12chr10

32197100

-SORCS3chr10

106916896

+
In-frameENST00000311380ENST00000369701ARHGAP12chr10

32197100

-SORCS3chr10

106916896

+
intron-3CDSENST00000492028ENST00000369701ARHGAP12chr10

32197100

-SORCS3chr10

106916896

+
intron-intronENST00000492028ENST00000369699ARHGAP12chr10

32197100

-SORCS3chr10

106916896

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000311380ARHGAP12chr1032197100-ENST00000369701SORCS3chr10106916896+4751703192889956

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000311380ENST00000369701ARHGAP12chr1032197100-SORCS3chr10106916896+0.0001227750.9998772

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Fusion Genomic Features for ARHGAP12-SORCS3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARHGAP12chr1032197099-SORCS3chr10106916895+4.27E-070.9999995
ARHGAP12chr1032197099-SORCS3chr10106916895+4.27E-070.9999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARHGAP12-SORCS3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:32197100/chr10:106916896)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP12

Q8IWW6

.
FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000311380-11612_74228795.0DomainSH3
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000344936-32012_74228847.0DomainSH3
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000375245-31812_74228795.0DomainSH3
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000375250-31812_74228817.0DomainSH3
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000396144-31912_74228842.0DomainSH3
TgeneSORCS3chr10:32197100chr10:106916896ENST00000369701827827_9174941223.0DomainPKD
TgeneSORCS3chr10:32197100chr10:106916896ENST00000369701827515_5264941223.0RepeatNote=BNR 4
TgeneSORCS3chr10:32197100chr10:106916896ENST00000369701827592_6034941223.0RepeatNote=BNR 5
TgeneSORCS3chr10:32197100chr10:106916896ENST00000369701827634_6454941223.0RepeatNote=BNR 6
TgeneSORCS3chr10:32197100chr10:106916896ENST000003697018271147_12224941223.0Topological domainCytoplasmic
TgeneSORCS3chr10:32197100chr10:106916896ENST000003697018271126_11464941223.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000311380-116265_298228795.0DomainWW 1
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000311380-116358_391228795.0DomainWW 2
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000311380-116463_575228795.0DomainPH
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000311380-116656_844228795.0DomainRho-GAP
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000344936-320265_298228847.0DomainWW 1
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000344936-320358_391228847.0DomainWW 2
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000344936-320463_575228847.0DomainPH
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000344936-320656_844228847.0DomainRho-GAP
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000375245-318265_298228795.0DomainWW 1
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000375245-318358_391228795.0DomainWW 2
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000375245-318463_575228795.0DomainPH
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000375245-318656_844228795.0DomainRho-GAP
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000375250-318265_298228817.0DomainWW 1
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000375250-318358_391228817.0DomainWW 2
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000375250-318463_575228817.0DomainPH
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000375250-318656_844228817.0DomainRho-GAP
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000396144-319265_298228842.0DomainWW 1
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000396144-319358_391228842.0DomainWW 2
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000396144-319463_575228842.0DomainPH
HgeneARHGAP12chr10:32197100chr10:106916896ENST00000396144-319656_844228842.0DomainRho-GAP
TgeneSORCS3chr10:32197100chr10:106916896ENST00000369701827231_2424941223.0RepeatNote=BNR 1
TgeneSORCS3chr10:32197100chr10:106916896ENST00000369701827279_2904941223.0RepeatNote=BNR 2
TgeneSORCS3chr10:32197100chr10:106916896ENST00000369701827320_3314941223.0RepeatNote=BNR 3
TgeneSORCS3chr10:32197100chr10:106916896ENST0000036970182734_11254941223.0Topological domainLumenal


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Fusion Gene Sequence for ARHGAP12-SORCS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5937_5937_1_ARHGAP12-SORCS3_ARHGAP12_chr10_32197100_ENST00000311380_SORCS3_chr10_106916896_ENST00000369701_length(transcript)=4751nt_BP=703nt
GAGAGGTGAATATTATTGAATGAAAATGGCTGACAGAAGTGGGAAGATTATTCCAGGACAAGTGTATATTGAGGTGGAATATGATTATGA
ATATGAAGCAAAGGACAGAAAGATTGTGATAAAACAAGGGGAGAGGTACATCTTGGTGAAAAAGACCAATGATGACTGGTGGCAAGTCAA
GCCAGATGAAAACTCCAAAGCGTTTTATGTGCCAGCCCAGTATGTGAAGGAGGTCACGCGCAAAGCTCTCATGCCACCTGTTAAGCAGGT
AGCTGGTCTGCCAAATAACTCCACGAAAATAATGCAGAGTTTGCATCTTCAGAGATCAACAGAAAATGTGAACAAATTGCCTGAGCTTTC
AAGTTTCGGAAAGCCATCGTCATCTGTTCAAGGAACAGGTCTTATTCGTGATGCCAATCAGAATTTTGGACCCAGTTATAATCAAGGTCA
GACTGTCAACCTAAGCCTGGACCTGACCCATAATAACGGAAAGTTTAACAATGACTCACATTCTCCTAAAGTTTCCAGCCAGAATAGGAC
ACGCTCATTTGGTCATTTTCCCGGTCCAGAGTTCTTGGATGTAGAGAAAACTAGCTTCTCCCAGGAACAATCTTGTGATTCCGCAGGAGA
AGGCTCTGAAAGAATACATCAAGATTCTGAATCTGGTGATGAACTTAGCAGCAGCTCCACTGAACAGATAAGGGTAGCAGGTATCAAAGG
GATATTTCTGGCAAACAAGAAGGTGGACGACCAGGTGAAGACATACATCACTTACAACAAAGGCAGGGATTGGCGCCTGCTGCAAGCTCC
GGATGTGGACCTGAGAGGAAGCCCAGTGCACTGCCTGCTGCCCTTCTGTTCCTTACATCTGCACCTGCAACTCTCTGAAAATCCATATTC
CTCAGGAAGAATCTCTAGCAAGGAGACAGCCCCAGGACTTGTGGTGGCTACAGGCAACATTGGCCCGGAGCTCTCATATACTGATATTGG
TGTGTTCATCTCCTCCGATGGGGGCAACACATGGAGACAGATCTTTGATGAAGAGTACAATGTCTGGTTCCTAGACTGGGGTGGTGCCCT
CGTGGCCATGAAACACACACCTCTGCCAGTCAGGCATTTGTGGGTGAGTTTTGATGAGGGCCACTCTTGGGACAAGTATGGTTTCACTTC
GGTTCCTCTCTTTGTTGACGGGGCTCTGGTGGAGGCAGGAATGGAGACCCACATCATGACAGTTTTTGGCCACTTCAGCCTCCGCTCCGA
ATGGCAATTGGTGAAAGTGGACTACAAATCTATCTTCAGCCGGCATTGCACCAAGGAGGACTATCAGACCTGGCACCTGCTCAATCAGGG
AGAGCCTTGTGTCATGGGAGAAAGGAAAATATTCAAGAAACGTAAGCCAGGAGCTCAGTGTGCCCTGGGCCGAGACCACTCAGGATCAGT
GGTCTCAGAACCCTGTGTCTGTGCCAATTGGGACTTCGAGTGTGACTATGGGTATGAGAGACATGGGGAGAGCCAGTGTGTCCCAGCTTT
CTGGTACAATCCAGCATCCCCATCAAAGGACTGCAGCCTTGGTCAAAGCTACCTTAACAGCACTGGGTATCGGCGGATTGTGTCCAACAA
CTGCACAGATGGGCTAAGGGAGAAGTACACCGCCAAGGCCCAGATGTGCCCTGGAAAAGCCCCTCGGGGCCTCCATGTGGTGACGACCGA
TGGGCGGCTGGTGGCAGAGCAGGGGCACAATGCAACTTTCATCATCCTCATGGAGGAGGGTGATCTACAAAGGACAAACATCCAGCTTGA
CTTTGGGGATGGGATTGCTGTGTCCTACGCAAACTTCAGCCCCATCGAGGACGGCATCAAGCACGTGTATAAGAGTGCGGGGATCTTCCA
GGTGACAGCCTATGCAGAGAACAACCTTGGCTCAGACACAGCTGTCCTCTTCCTGCATGTGGTTTGTCCTGTGGAGCATGTTCATCTCCG
AGTTCCATTTGTTGCCATAAGAAATAAGGAGGTCAACATCAGTGCAGTCGTGTGGCCCAGTCAACTGGGGACCCTTACCTATTTCTGGTG
GTTCGGCAATAGCACAAAGCCTCTCATCACTTTGGACAGCAGCATTTCCTTCACATTCCTTGCAGAAGGAACCGACACCATCACAGTCCA
GGTGGCTGCTGGGAATGCCCTCATCCAGGACACAAAAGAGATTGCAGTTCATGAATATTTCCAGTCCCAGCTTTTATCATTCTCTCCTAA
TCTGGATTACCACAATCCTGACATTCCTGAGTGGAGAAAAGATATTGGCAATGTCATCAAGCGAGCTCTGGTTAAAGTAACCAGTGTCCC
AGAGGACCAGATCCTCATTGCCGTGTTTCCTGGTCTCCCCACTTCAGCAGAGCTTTTCATTCTTCCACCCAAGAACCTGACAGAGAGGAG
GAAAGGCAATGAAGGGGACCTGGAACAAATTGTAGAAACACTGTTTAATGCTCTCAACCAAAATTTGGTCCAGTTTGAGCTGAAGCCGGG
GGTACAAGTCATTGTGTATGTCACACAGCTGACGTTAGCTCCATTGGTGGACTCCAGTGCTGGGCACAGCAGCTCAGCCATGCTTATGCT
ATTATCAGTGGTATTTGTTGGCCTGGCTGTGTTTTTGATCTACAAGTTTAAAAGGAAAATCCCTTGGATTAACATCTATGCTCAAGTCCA
ACACGACAAGGAGCAGGAGATGATTGGGTCAGTGAGCCAAAGTGAAAACGCCCCCAAAATCACACTCAGTGACTTTACGGAGCCTGAGGA
GCTGCTGGACAAAGAGCTGGACACGCGGGTCATAGGAGGCATTGCCACTATTGCAAACAGCGAAAGCACAAAGGAGATCCCCAACTGCAC
TAGTGTTTAATACCAGCAAGCCACGTGGTCAACCACCTTTCTGACTTTTTATTTTTGATGATTACTATTACTATTATTATGGAAAAATTA
AAATGTCTTTTTTACCTTTTGTTTACCAAGGGCCCCTTCATAAATAGCAGGCAAATGCCTAGCTTTGGGAGAAAAGGGCATTCTTAGCTG
ATTGAAATGAGACAAAGGGAATAAATGGCTGTATTTGTGCTAAGAGCAAAGGATGCATCTTCCCACAGCCTCCTCGCTTTACTCTGCCAT
TGGTAGCTTAAAGACTTTCTTTTTCCTTGTGGTCTCCCTTTTTTCAAAATTGAAGTTGGGTTGGCTCTTTGTGAACCTCTCATCCCCACA
GCAGAATCACCAACACTCTCCGCTTCCCCCAGCACACACACATACAACACAGATCATTTCCCAGTTAGATCCGCAGGAAGTAGGTTGGTG
GGGGTGGATGTAGCTGCAGAAAGCATGCACAACTTTGTGAAAGAGGCCCTGCCTTGTGCATGTCCATAGTGAGGCTACAGATGGCTTATT
GTATATAATTACAATGTAAATAGCTTTTTATTTCCTAAGAAATAATTTAATGTTTAGTAAAAAAGAAAACAGAAAAAAGAAAGATGCGTG
TGTTGGCTTACGCACTGGCCCTCAGAGCTGACCAACCCGCCAGGCCTGCTCAATGCATTGGGTTTGGATGCTCTCCTGTTGTCTGTCACA
CTTAACTCTTGCATCTCCTTGTCCATGCCATAGCTGGTTTCTACTTATGTATATAAAGGGGGGTGGGGGGAGGGGCTTCTCTGGGGCAAT
TGATAAAGGAAGGACTCTAGTGACATCATAGAACATGGCAGTCGTTTTTGTTCCAAGAATGATATGAAAGGTGAAGAAGAGGCCCACTAG
AGGCTTCATACTGAGACCCAGATGGGGGAAAACAGCTTCCTCTCTAAAAGGAAAAACTTGATATTTATCAGTCTGAGAAAATATTTTTTT
CTAAAGAAGGCAGTCAGTGGATCTTAAAATGACAATCTGTTTTTAAATTGGATTCTATGAAAATGCATAATGCTTATGGTGAATTCTCAG
GCTATTCTGAGCTCAGAAAAGTCCCCTGGGCACTAGGTAAAGCCCAGTGAATGTCTCTTGGCATGGGAGGAGTTAAAGAGGTTGGAAGGG
AAGAGGCATTTGTGGAATTATGAGTTCATGCAAAACTCTCCAGGCCAAGTAGGGGTCTAGCCTTTAATGATATTAGTCAAAGGCAATTTT
AGCAAAGCTGTGCTATTTGCTTGTCAGATGTACACAACTTCCTTAAAGTCAAATGTCTGCCTTCAGTTCCCTTAAGGTAGTTCTTGCCTC
TGGGGTGAGTGGCTTTCAAAGCCTTTTAGCTTTTCCAGCACCTCAGCCCCTTCACACATTTACACATACCAATTTTTTTCAATAGGGTCA
CGTTAAGCCATGCTGTAAGCATTGTTTTTATTTTCAGGCTTAGCCTGAGCACACTTATTTTTGAAAATGATATAATGTATATATATGGGA
GGAAAGGCCACATTTTGTACCTGTTAATTTTTGTGGGATGTTGTTCCCATTCTTCTTTGTGAGACAGAGAGAATGTGATATAGAGAAATC
TGGCTGGCTACAGTGTAGATCAGTATTAGGAATATTTCTAAAGATCCTGCTTTTTTGTTTCAAGGGTTAAATGGGGCAGACAATTGCAAT
ACTTGTACTAAACACTGGAATACAAATGCATGACTCATATCTATATATACAGTATATGTACATATACTGTTCTTGGTTTTATTGTTCCAC

>5937_5937_1_ARHGAP12-SORCS3_ARHGAP12_chr10_32197100_ENST00000311380_SORCS3_chr10_106916896_ENST00000369701_length(amino acids)=956AA_BP=228
MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSKAFYVPAQYVKEVTRKALMPPVKQVAGLPNN
STKIMQSLHLQRSTENVNKLPELSSFGKPSSSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHF
PGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRVAGIKGIFLANKKVDDQVKTYITYNKGRDWRLLQAPDVDLRG
SPVHCLLPFCSLHLHLQLSENPYSSGRISSKETAPGLVVATGNIGPELSYTDIGVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMKHT
PLPVRHLWVSFDEGHSWDKYGFTSVPLFVDGALVEAGMETHIMTVFGHFSLRSEWQLVKVDYKSIFSRHCTKEDYQTWHLLNQGEPCVMG
ERKIFKKRKPGAQCALGRDHSGSVVSEPCVCANWDFECDYGYERHGESQCVPAFWYNPASPSKDCSLGQSYLNSTGYRRIVSNNCTDGLR
EKYTAKAQMCPGKAPRGLHVVTTDGRLVAEQGHNATFIILMEEGDLQRTNIQLDFGDGIAVSYANFSPIEDGIKHVYKSAGIFQVTAYAE
NNLGSDTAVLFLHVVCPVEHVHLRVPFVAIRNKEVNISAVVWPSQLGTLTYFWWFGNSTKPLITLDSSISFTFLAEGTDTITVQVAAGNA
LIQDTKEIAVHEYFQSQLLSFSPNLDYHNPDIPEWRKDIGNVIKRALVKVTSVPEDQILIAVFPGLPTSAELFILPPKNLTERRKGNEGD
LEQIVETLFNALNQNLVQFELKPGVQVIVYVTQLTLAPLVDSSAGHSSSAMLMLLSVVFVGLAVFLIYKFKRKIPWINIYAQVQHDKEQE

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Fusion Gene PPI Analysis for ARHGAP12-SORCS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP12-SORCS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGAP12-SORCS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource