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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGEF6-TMEM48 (FusionGDB2 ID:HG9459TG55706)

Fusion Gene Summary for ARHGEF6-TMEM48

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGEF6-TMEM48
Fusion gene ID: hg9459tg55706
HgeneTgene
Gene symbol

ARHGEF6

TMEM48

Gene ID

9459

55706

Gene nameRac/Cdc42 guanine nucleotide exchange factor 6NDC1 transmembrane nucleoporin
SynonymsCOOL2|Cool-2|MRX46|PIXA|alpha-PIX|alphaPIXNET3|TMEM48
Cytomap('ARHGEF6','ARHGEF6')('NDC1','TMEM48')

Xq26.3

1p32.3

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 6PAK-interacting exchange factor, alphaRac/Cdc42 guanine exchange factor (GEF) 6Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6nucleoporin NDC1nuclear division cycle 1 homologtransmembrane protein 48
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000250617, ENST00000370620, 
ENST00000370622, ENST00000535227, 
Fusion gene scores* DoF score1 X 1 X 1=18 X 6 X 7=336
# samples 19
** MAII scorelog2(1/1*10)=3.32192809488736log2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGEF6 [Title/Abstract] AND TMEM48 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGEF6(135814261)-NDC1(54275419), # samples:1
ARHGEF6(135814261)-TMEM48(54275419), # samples:1
Anticipated loss of major functional domain due to fusion event.ARHGEF6-NDC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF6-NDC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF6-NDC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF6-NDC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF6-NDC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ARHGEF6-NDC1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARHGEF6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TMEM48 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-X6-A8C2-01AARHGEF6chrX

135814261

-NDC1chr1

54275419

-
ChimerDB4SARCTCGA-X6-A8C2-01AARHGEF6chrX

135814261

-TMEM48chr1

54275419

-


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Fusion Gene ORF analysis for ARHGEF6-TMEM48

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000250617ENST00000234725ARHGEF6chrX

135814261

-NDC1chr1

54275419

-
5CDS-5UTRENST00000250617ENST00000537333ARHGEF6chrX

135814261

-NDC1chr1

54275419

-
5CDS-5UTRENST00000370620ENST00000234725ARHGEF6chrX

135814261

-NDC1chr1

54275419

-
5CDS-5UTRENST00000370620ENST00000537333ARHGEF6chrX

135814261

-NDC1chr1

54275419

-
5CDS-5UTRENST00000370622ENST00000234725ARHGEF6chrX

135814261

-NDC1chr1

54275419

-
5CDS-5UTRENST00000370622ENST00000537333ARHGEF6chrX

135814261

-NDC1chr1

54275419

-
5CDS-5UTRENST00000535227ENST00000234725ARHGEF6chrX

135814261

-NDC1chr1

54275419

-
5CDS-5UTRENST00000535227ENST00000537333ARHGEF6chrX

135814261

-NDC1chr1

54275419

-
5CDS-intronENST00000250617ENST00000480952ARHGEF6chrX

135814261

-NDC1chr1

54275419

-
5CDS-intronENST00000370620ENST00000480952ARHGEF6chrX

135814261

-NDC1chr1

54275419

-
5CDS-intronENST00000370622ENST00000480952ARHGEF6chrX

135814261

-NDC1chr1

54275419

-
5CDS-intronENST00000535227ENST00000480952ARHGEF6chrX

135814261

-NDC1chr1

54275419

-
Frame-shiftENST00000250617ENST00000371429ARHGEF6chrX

135814261

-NDC1chr1

54275419

-
Frame-shiftENST00000250617ENST00000540001ARHGEF6chrX

135814261

-NDC1chr1

54275419

-
In-frameENST00000370620ENST00000371429ARHGEF6chrX

135814261

-NDC1chr1

54275419

-
In-frameENST00000370620ENST00000540001ARHGEF6chrX

135814261

-NDC1chr1

54275419

-
In-frameENST00000370622ENST00000371429ARHGEF6chrX

135814261

-NDC1chr1

54275419

-
In-frameENST00000370622ENST00000540001ARHGEF6chrX

135814261

-NDC1chr1

54275419

-
In-frameENST00000535227ENST00000371429ARHGEF6chrX

135814261

-NDC1chr1

54275419

-
In-frameENST00000535227ENST00000540001ARHGEF6chrX

135814261

-NDC1chr1

54275419

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000370620ARHGEF6chrX135814261-ENST00000371429NDC1chr154275419-45156837152004429
ENST00000370620ARHGEF6chrX135814261-ENST00000540001NDC1chr154275419-44026837151608297
ENST00000370622ARHGEF6chrX135814261-ENST00000371429NDC1chr154275419-45306987302019429
ENST00000370622ARHGEF6chrX135814261-ENST00000540001NDC1chr154275419-44176987301623297
ENST00000535227ARHGEF6chrX135814261-ENST00000371429NDC1chr154275419-46458138452134429
ENST00000535227ARHGEF6chrX135814261-ENST00000540001NDC1chr154275419-45328138451738297

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000370620ENST00000371429ARHGEF6chrX135814261-NDC1chr154275419-0.0012493680.99875057
ENST00000370620ENST00000540001ARHGEF6chrX135814261-NDC1chr154275419-0.0102876420.98971236
ENST00000370622ENST00000371429ARHGEF6chrX135814261-NDC1chr154275419-0.0010787120.9989213
ENST00000370622ENST00000540001ARHGEF6chrX135814261-NDC1chr154275419-0.0088162080.99118376
ENST00000535227ENST00000371429ARHGEF6chrX135814261-NDC1chr154275419-0.0013638870.99863607
ENST00000535227ENST00000540001ARHGEF6chrX135814261-NDC1chr154275419-0.0113012540.9886988

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Fusion Genomic Features for ARHGEF6-TMEM48


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ARHGEF6-TMEM48


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:135814261/:54275419)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF6chrX:135814261chr1:54275419ENST00000250617-622160_219244777.0DomainSH3
HgeneARHGEF6chrX:135814261chr1:54275419ENST00000250617-6221_111244777.0DomainCalponin-homology (CH)
TgeneNDC1chrX:135814261chr1:54275419ENST00000371429518247_272234675.0Topological domainPerinuclear space
TgeneNDC1chrX:135814261chr1:54275419ENST00000371429518294_674234675.0Topological domainCytoplasmic
TgeneNDC1chrX:135814261chr1:54275419ENST00000540001517247_2722341297.0Topological domainPerinuclear space
TgeneNDC1chrX:135814261chr1:54275419ENST00000540001517294_6742341297.0Topological domainCytoplasmic
TgeneNDC1chrX:135814261chr1:54275419ENST00000371429518273_293234675.0TransmembraneHelical%3B Name%3D6
TgeneNDC1chrX:135814261chr1:54275419ENST00000540001517273_2932341297.0TransmembraneHelical%3B Name%3D6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF6chrX:135814261chr1:54275419ENST00000250617-622241_421244777.0DomainDH
HgeneARHGEF6chrX:135814261chr1:54275419ENST00000250617-622443_548244777.0DomainPH
HgeneARHGEF6chrX:135814261chr1:54275419ENST00000370620-521160_21990623.0DomainSH3
HgeneARHGEF6chrX:135814261chr1:54275419ENST00000370620-5211_11190623.0DomainCalponin-homology (CH)
HgeneARHGEF6chrX:135814261chr1:54275419ENST00000370620-521241_42190623.0DomainDH
HgeneARHGEF6chrX:135814261chr1:54275419ENST00000370620-521443_54890623.0DomainPH
HgeneARHGEF6chrX:135814261chr1:54275419ENST00000370622-521160_21990623.0DomainSH3
HgeneARHGEF6chrX:135814261chr1:54275419ENST00000370622-5211_11190623.0DomainCalponin-homology (CH)
HgeneARHGEF6chrX:135814261chr1:54275419ENST00000370622-521241_42190623.0DomainDH
HgeneARHGEF6chrX:135814261chr1:54275419ENST00000370622-521443_54890623.0DomainPH
TgeneNDC1chrX:135814261chr1:54275419ENST00000371429518136_165234675.0Topological domainPerinuclear space
TgeneNDC1chrX:135814261chr1:54275419ENST00000371429518187_225234675.0Topological domainCytoplasmic
TgeneNDC1chrX:135814261chr1:54275419ENST000003714295181_24234675.0Topological domainCytoplasmic
TgeneNDC1chrX:135814261chr1:54275419ENST0000037142951846_68234675.0Topological domainPerinuclear space
TgeneNDC1chrX:135814261chr1:54275419ENST0000037142951890_114234675.0Topological domainCytoplasmic
TgeneNDC1chrX:135814261chr1:54275419ENST00000540001517136_1652341297.0Topological domainPerinuclear space
TgeneNDC1chrX:135814261chr1:54275419ENST00000540001517187_2252341297.0Topological domainCytoplasmic
TgeneNDC1chrX:135814261chr1:54275419ENST000005400015171_242341297.0Topological domainCytoplasmic
TgeneNDC1chrX:135814261chr1:54275419ENST0000054000151746_682341297.0Topological domainPerinuclear space
TgeneNDC1chrX:135814261chr1:54275419ENST0000054000151790_1142341297.0Topological domainCytoplasmic
TgeneNDC1chrX:135814261chr1:54275419ENST00000371429518115_135234675.0TransmembraneHelical%3B Name%3D3
TgeneNDC1chrX:135814261chr1:54275419ENST00000371429518166_186234675.0TransmembraneHelical%3B Name%3D4
TgeneNDC1chrX:135814261chr1:54275419ENST00000371429518226_246234675.0TransmembraneHelical%3B Name%3D5
TgeneNDC1chrX:135814261chr1:54275419ENST0000037142951825_45234675.0TransmembraneHelical%3B Name%3D1
TgeneNDC1chrX:135814261chr1:54275419ENST0000037142951869_89234675.0TransmembraneHelical%3B Name%3D2
TgeneNDC1chrX:135814261chr1:54275419ENST00000540001517115_1352341297.0TransmembraneHelical%3B Name%3D3
TgeneNDC1chrX:135814261chr1:54275419ENST00000540001517166_1862341297.0TransmembraneHelical%3B Name%3D4
TgeneNDC1chrX:135814261chr1:54275419ENST00000540001517226_2462341297.0TransmembraneHelical%3B Name%3D5
TgeneNDC1chrX:135814261chr1:54275419ENST0000054000151725_452341297.0TransmembraneHelical%3B Name%3D1
TgeneNDC1chrX:135814261chr1:54275419ENST0000054000151769_892341297.0TransmembraneHelical%3B Name%3D2


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Fusion Gene Sequence for ARHGEF6-TMEM48


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6336_6336_1_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000370620_NDC1_chr1_54275419_ENST00000371429_length(transcript)=4515nt_BP=683nt
AGTTTCGCCCTGGTGGCGGCCGCGCTCAGGGCAGGGTCCCAGCTCCGGCTGGGTTGATCTGTTCCCGCAGCCTTGGCACAGGCTTGCCCG
CCCGCTCGCCGGCCCCGTGACTCGGGAGGGCGAACGGCTTCCAGGAGGCGGCGGCGGCGCGGCTGGAGTGAGGGAGCAGCTGGAGGACAG
GCGGGCAGCGGCCGAGCCAGATATTTGATCCTGATGACCTTTATTCAGGGGTCAATTTCTCCAAGGTACTGAGTACTCTTTTAGCTGTCA
ACAAAGCAACAGAAGATCAGCTATCAGAAAGACCATGTGGACGTTCCTCTTCTCTTAGTGCTGCTAATACTTCTCAGACAAACCCACAGG
GAGCAGTTTCTAGCACAGTTTCAGGGCTGCAAAGGCAGTCAAAGACAGTGGAGATGACGGAAAATGGAAGTCATCAGTTGATAGTAAAAG
CAAGATTCAACTTTAAGCAGACTAATGAGGATGAACTGTCAGTTTGTAAGGGGGACATCATTTACGTCACACGAGTTGAAGAAGGAGGCT
GGTGGGAAGGCACATTAAATGGGAGAACAGGCTGGTTCCCCAGTAATTATGTCCGTGAAATTAAATCCAGTGAGAGACCTCTCTCCCCAA
AAGCCGTCAAAGGATTTGAAACTGCTCCACTTACCAAGAATTATTATACTGTGGCTATATTCCCAAAGCTTGGATTAGCACTGCTATGAA
CCTTCACATAGATGAGCAGGTTCATAGGCCACTTGACACAGTGAGTGGCCTCTTAAATCTCTCGTTACTCTACCATGTCTGGCTGTGTGG
TGTCTTTCTCCTGACGACTTGGTATGTCTCATGGATACTCTTCAAAATCTATGCCACAGAGGCTCATGTGTTTCCTGTTCAACCACCATT
TGCAGAAGGGTCAGATGAGTGCCTTCCAAAAGTGTTAAATAGCAATCCTCCCCCCATCATAAAGTATTTAGCCTTGCAGGACCTGATGTT
GCTTTCTCAATATTCTCCTTCACGAAGACAAGAAGTTTTCAGCCTCAGCCAACCAGGTGGACATCCCCACAATTGGACAGCCATTTCAAG
GGAGTGTTTGAATCTTTTAAATGGTATGACTCAGAAACTGATTCTCTATCAAGAAGCTGCTGCTACGAATGGGAGAGTGTCTTCATCTTA
CCCAGTGGAACCTAAGAAATTAAATTCTCCAGAAGAAACTGCTTTTCAGACACCAAAATCTAGCCAGATGCCTCGGCCTTCAGTGCCACC
ATTAGTTAAAACATCACTGTTTTCTTCAAAATTATCTACACCTGATGTTGTGAGCCCATTTGGGACCCCATTTGGCTCTAGTGTAATGAA
TCGGATGGCTGGAATTTTTGATGTAAACACCTGCTATGGGTCACCGCAAAGTCCTCAGCTAATAAGAAGGGGGCCAAGATTGTGGACATC
AGCTTCTGATCAGCAAATGACTGAATTTTCTAATCCTTCTCCATCTACCTCTATTAGTGCTGAGGGTAAGACAATGAGACAACCCAGTGT
GATTTATTCATGGATTCAGAATAAACGTGAACAGATTAAGAATTTCTTGTCAAAACGGGTGCTGATAATGTATTTTTTCAGTAAGCACCC
AGAGGCCTCCATTCAGGCTGTTTTTTCAGATGCCCAAATGCATATTTGGGCATTAGAAGGTCTGTCGCACTTAGTAGCAGCATCATTTAC
AGAGGATAGATTTGGAGTTGTCCAGACGACACTACCAGCTATCCTTAATACTTTGTTGACACTGCAAGAGGCAGTCGACAAGTACTTTAA
GCTTCCTCATGCTTCCAGTAAACCACCCCGGATTTCAGGAAGCCTTGTGGACACTTCATATAAAACATTAAGATTTGCATTCAGAGCATC
ACTGAAAACTGCCATCTATCGAATAACTACTACATTTGGTGAACATCTGAATGCTGTGCAAGCATCTGCAGAACATCAGAAAAGACTTCA
ACAGTTCTTGGAGTTCAAAGAATAGTTAAGTAATATAAACTGTGTTCATTACACTGCTGATACAACTACAGATGGGACAGTAAATGTTCA
GCATTCTTGGATCAGAAGAAAACGGACTAATTAGATGCTTCCTTTGTCGTGGTGGTTGCTTTGAAAACTATACTTTAATGGGAGAAATCA
TGGAAAGAAATTCTCAACAGAATAACTGAAAACTGCCTTTTCTGTACCGATTGCTTTTTGTGTGTGTGGTATAATAAAATCTTTATTCAA
TTTTACAGAAGCATTGATGGCAGTCGAAATGTCTCTAGCTCATATAACTTAATAGTAATAACTAAAAAACTTTTAGAATTTACTTTTGAA
AGGAGGGAAGCCAGTTCTGAAATGAGTATAGGTTGATTTCATAGTCTTCTTAATTAAGAGTTTAGCTCTTTGTAAACTCAAAATACATAA
ACTTTTTAAGTGTAGTTTCATTTACTGAAGGATAAAAATGGTAACAGTGCAGCAATATTCACAAAAAATATTGTCTAACGGACATATTTT
GTTAATCTGTTAGGTTGGGTTTTTGTTTCCAGGGACAAATTAAATTTGTATGATTACCCAAAAAAGGGTCTCAGTTTACAGATGCTAACT
CTATATAAAGGAATGTGGAAAAACTCAGTTCTTAAGTTACAAGATTAAAAATTCACATTTGGTCTTTAAGAAACAATTGACTGACATCTA
TGAATTTATTTTGTATCATGCTAGTAAACACGAAGTATTAATGTATGGGTATTTTCCCAGCTAGTTTTGCTTTCTTTTTCTGGAGCAAAA
CATTAAGTGATTGCAGAGTTTTTCAAGCAAGAGAAAAAGGTTTGCAAAAAAACCCAGGAAATGTTCCCTTTTTTCCCCACCATTCATCTT
CATTAGATCAAATTCTGTGAAACTTGTCTGGTCTCTCAAAGGGAGCAGCCTCTGTAGTGTTAAATGGCTAATTAAAATAGGAAGATCTTT
ATAGCCAGAAACAACTTAGTCATCAAATAGCAAGTGAAACCAAAACGTCAGAGGGATTACTGTACTTGGAAGTATGTTGTGTGTCCCAAA
TGTGAACGAAGTATTGTTAGAATTTATTAGATCAGCTTCTTTGGAGATCAAAGATTGGAAATCCTAGTCATAGATATTCACTGGACTGGC
TTTGGACTGAAATGCTCCTTTGTAATTCTTTTCCTATTGTCTTTTCCTTCTAGTGTCCCAAAATATTTTCTTTAAAGTCAGCACAGTACT
GTATATGAATCTTTAATGTGGTATCATATATGTCTACTTTTGTCTGATTCATCGATGTATTATATCTTTATAATTGAATATTTTAGCTCC
GGGTCCTGTTGCCCCTTCAAGCAGTACATGCCAAATTATAAATAGGTGCTACTGGCCTTGAGCATATCACTGTGGGACAGTTCCCCAATT
GTCAAGTGTTTAGATATGTAGACTATTGCCATTTGTTTTTTTGTTTTGGTTTTGCTTTGTGTCTGAAGCTGAATTGATTTCTTTTTTTTG
AATGTGAAAGTTGAATTTCAAACGTAGTCATTTCTTACAGATGGCCAAGACAGAAAATTGTGGCTAGGTTGACTGAGAACTGTTGTCTTC
CATGTATTAACACAATTAAGCTTTTTATATTCCACTCTCTGTGCTGACCCTGGCTGAGGCATTTTGGGAGACAAGGACTCTGAATCTTCT
GCTTCCATTAAAGAAGAACTGTGATATTCAACATTGGATTTCTGAGAATAAAGATAGGATGATTCCTTTGAACTTTGACTTACTTGTATA
AAATGTCCAGCTAGGTTAGGTTTTTGCCATTTCCTATATACTTTGGGTAAAGCTACATTTGATGAGCAATGTGAATGTTTCTGAGAATGT
TCATTCCTGTTTTCTCTTAAGAGAATGTGCTGTGTACTAAATACAGGCCACATAGTGTCTGCCTGTTGAAGATCTGGAAACTGCCTCCCC
AGATCTGTATTGTATTTGGTAGGTAAGGGGGTCAGTTTCTTTTTCTCATTGTGTGTTGATAATCTACACACCATCTGTTGGAACCAGGGT
GTTATTATGGGGAACTCCTCCTGTGTACTAGGAGGAGGACCTTAGGGAGACCAAGAGGAGAGAAGCATTTCCTTTGATGAAGTCACATCC
TGTCTATGAGCCCACTAATGCTGTAACATTGGCCTGAAAGAGAGTGTTCTTTAAAAGCCTTTCTCGGCTGTTAGTATAAAAACATGATGG
TATCAGCTCTTAGCATGTTTGCTTGACCCTTATGGAAGGTATAAATCCACAGAACTTCCTTCCCAGAGAACTGGGAAATTGTCCTAGAAA
TAAACCTTGTACAGTTGAGTGGACATGGATAAGCAACAATTTGTTACTTTGCAGGATTTGTTCCTTGGTAATTGTTTGGTGTGTCATCCT
GTAAATATTCATGATAGTCTGTTTATATCCTTTTGTATATCGTTGATACTGGATTGGGTAGAAAAATAAATTGGCAATTTAAAAAAATGG
AACAGTTAATTGAAA

>6336_6336_1_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000370620_NDC1_chr1_54275419_ENST00000371429_length(amino acids)=429AA_BP=
MNLHIDEQVHRPLDTVSGLLNLSLLYHVWLCGVFLLTTWYVSWILFKIYATEAHVFPVQPPFAEGSDECLPKVLNSNPPPIIKYLALQDL
MLLSQYSPSRRQEVFSLSQPGGHPHNWTAISRECLNLLNGMTQKLILYQEAAATNGRVSSSYPVEPKKLNSPEETAFQTPKSSQMPRPSV
PPLVKTSLFSSKLSTPDVVSPFGTPFGSSVMNRMAGIFDVNTCYGSPQSPQLIRRGPRLWTSASDQQMTEFSNPSPSTSISAEGKTMRQP
SVIYSWIQNKREQIKNFLSKRVLIMYFFSKHPEASIQAVFSDAQMHIWALEGLSHLVAASFTEDRFGVVQTTLPAILNTLLTLQEAVDKY
FKLPHASSKPPRISGSLVDTSYKTLRFAFRASLKTAIYRITTTFGEHLNAVQASAEHQKRLQQFLEFKE

--------------------------------------------------------------
>6336_6336_2_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000370620_NDC1_chr1_54275419_ENST00000540001_length(transcript)=4402nt_BP=683nt
AGTTTCGCCCTGGTGGCGGCCGCGCTCAGGGCAGGGTCCCAGCTCCGGCTGGGTTGATCTGTTCCCGCAGCCTTGGCACAGGCTTGCCCG
CCCGCTCGCCGGCCCCGTGACTCGGGAGGGCGAACGGCTTCCAGGAGGCGGCGGCGGCGCGGCTGGAGTGAGGGAGCAGCTGGAGGACAG
GCGGGCAGCGGCCGAGCCAGATATTTGATCCTGATGACCTTTATTCAGGGGTCAATTTCTCCAAGGTACTGAGTACTCTTTTAGCTGTCA
ACAAAGCAACAGAAGATCAGCTATCAGAAAGACCATGTGGACGTTCCTCTTCTCTTAGTGCTGCTAATACTTCTCAGACAAACCCACAGG
GAGCAGTTTCTAGCACAGTTTCAGGGCTGCAAAGGCAGTCAAAGACAGTGGAGATGACGGAAAATGGAAGTCATCAGTTGATAGTAAAAG
CAAGATTCAACTTTAAGCAGACTAATGAGGATGAACTGTCAGTTTGTAAGGGGGACATCATTTACGTCACACGAGTTGAAGAAGGAGGCT
GGTGGGAAGGCACATTAAATGGGAGAACAGGCTGGTTCCCCAGTAATTATGTCCGTGAAATTAAATCCAGTGAGAGACCTCTCTCCCCAA
AAGCCGTCAAAGGATTTGAAACTGCTCCACTTACCAAGAATTATTATACTGTGGCTATATTCCCAAAGCTTGGATTAGCACTGCTATGAA
CCTTCACATAGATGAGCAGGTTCATAGGCCACTTGACACAGTGAGTGGCCTCTTAAATCTCTCGTTACTCTACCATGTCTGGCTGTGTGG
TGTCTTTCTCCTGACGACTTGGTATGTCTCATGGATACTCTTCAAAATCTATGCCACAGAGGCTCATGTGTTTCCTGTTCAACCACCATT
TGCAGAAGGGTCAGATGAGTGCCTTCCAAAAGTGTTAAATAGCAATCCTCCCCCCATCATAAAGTATTTAGCCTTGCAGGACCTGATGTT
GCTTTCTCAATATTCTCCTTCACGAAGACAAGAAGTTTTCAGCCTCAGCCAACCAGGTGGACATCCCCACAATTGGACAGCCATTTCAAG
GGAGTGTTTGAATCTTTTAAATGGTATGACTCAGAAACTGATTCTCTATCAAGAAGCTGCTGCTACGAATGGGAGAGTGTCTTCATCTTA
CCCAGTGGAACCTAAGAAATTAAATTCTCCAGAAGAAACTGCTTTTCAGACACCAAAATCTAGCCAGATGCCTCGGCCTTCAGTGCCACC
ATTAGTTAAAACATCACTGTTTTCTTCAAAATTATCTACACCTGATGTTGTGAGCCCATTTGGGACCCCATTTGGCTCTAGTGTAATGAA
TCGGATGGCTGGAATTTTTGATGTAAACACCTGCTATGGGTCACCGCAAAGTCCTCAGCTAATAAGAAGGGGGCCAAGATTGTGGACATC
AGCTTCTGATCAGCAAATGACTGAATTTTCTAATCCTTCTCCATCTACCTCTATTAGTGCTGAGGCACCCAGAGGCCTCCATTCAGGCTG
TTTTTTCAGATGCCCAAATGCATATTTGGGCATTAGAAGGTCTGTCGCACTTAGTAGCAGCATCATTTACAGAGGATAGATTTGGAGTTG
TCCAGACGACACTACCAGCTATCCTTAATACTTTGTTGACACTGCAAGAGGCAGTCGACAAGTACTTTAAGCTTCCTCATGCTTCCAGTA
AACCACCCCGGATTTCAGGAAGCCTTGTGGACACTTCATATAAAACATTAAGATTTGCATTCAGAGCATCACTGAAAACTGCCATCTATC
GAATAACTACTACATTTGGTGAACATCTGAATGCTGTGCAAGCATCTGCAGAACATCAGAAAAGACTTCAACAGTTCTTGGAGTTCAAAG
AATAGTTAAGTAATATAAACTGTGTTCATTACACTGCTGATACAACTACAGATGGGACAGTAAATGTTCAGCATTCTTGGATCAGAAGAA
AACGGACTAATTAGATGCTTCCTTTGTCGTGGTGGTTGCTTTGAAAACTATACTTTAATGGGAGAAATCATGGAAAGAAATTCTCAACAG
AATAACTGAAAACTGCCTTTTCTGTACCGATTGCTTTTTGTGTGTGTGGTATAATAAAATCTTTATTCAATTTTACAGAAGCATTGATGG
CAGTCGAAATGTCTCTAGCTCATATAACTTAATAGTAATAACTAAAAAACTTTTAGAATTTACTTTTGAAAGGAGGGAAGCCAGTTCTGA
AATGAGTATAGGTTGATTTCATAGTCTTCTTAATTAAGAGTTTAGCTCTTTGTAAACTCAAAATACATAAACTTTTTAAGTGTAGTTTCA
TTTACTGAAGGATAAAAATGGTAACAGTGCAGCAATATTCACAAAAAATATTGTCTAACGGACATATTTTGTTAATCTGTTAGGTTGGGT
TTTTGTTTCCAGGGACAAATTAAATTTGTATGATTACCCAAAAAAGGGTCTCAGTTTACAGATGCTAACTCTATATAAAGGAATGTGGAA
AAACTCAGTTCTTAAGTTACAAGATTAAAAATTCACATTTGGTCTTTAAGAAACAATTGACTGACATCTATGAATTTATTTTGTATCATG
CTAGTAAACACGAAGTATTAATGTATGGGTATTTTCCCAGCTAGTTTTGCTTTCTTTTTCTGGAGCAAAACATTAAGTGATTGCAGAGTT
TTTCAAGCAAGAGAAAAAGGTTTGCAAAAAAACCCAGGAAATGTTCCCTTTTTTCCCCACCATTCATCTTCATTAGATCAAATTCTGTGA
AACTTGTCTGGTCTCTCAAAGGGAGCAGCCTCTGTAGTGTTAAATGGCTAATTAAAATAGGAAGATCTTTATAGCCAGAAACAACTTAGT
CATCAAATAGCAAGTGAAACCAAAACGTCAGAGGGATTACTGTACTTGGAAGTATGTTGTGTGTCCCAAATGTGAACGAAGTATTGTTAG
AATTTATTAGATCAGCTTCTTTGGAGATCAAAGATTGGAAATCCTAGTCATAGATATTCACTGGACTGGCTTTGGACTGAAATGCTCCTT
TGTAATTCTTTTCCTATTGTCTTTTCCTTCTAGTGTCCCAAAATATTTTCTTTAAAGTCAGCACAGTACTGTATATGAATCTTTAATGTG
GTATCATATATGTCTACTTTTGTCTGATTCATCGATGTATTATATCTTTATAATTGAATATTTTAGCTCCGGGTCCTGTTGCCCCTTCAA
GCAGTACATGCCAAATTATAAATAGGTGCTACTGGCCTTGAGCATATCACTGTGGGACAGTTCCCCAATTGTCAAGTGTTTAGATATGTA
GACTATTGCCATTTGTTTTTTTGTTTTGGTTTTGCTTTGTGTCTGAAGCTGAATTGATTTCTTTTTTTTGAATGTGAAAGTTGAATTTCA
AACGTAGTCATTTCTTACAGATGGCCAAGACAGAAAATTGTGGCTAGGTTGACTGAGAACTGTTGTCTTCCATGTATTAACACAATTAAG
CTTTTTATATTCCACTCTCTGTGCTGACCCTGGCTGAGGCATTTTGGGAGACAAGGACTCTGAATCTTCTGCTTCCATTAAAGAAGAACT
GTGATATTCAACATTGGATTTCTGAGAATAAAGATAGGATGATTCCTTTGAACTTTGACTTACTTGTATAAAATGTCCAGCTAGGTTAGG
TTTTTGCCATTTCCTATATACTTTGGGTAAAGCTACATTTGATGAGCAATGTGAATGTTTCTGAGAATGTTCATTCCTGTTTTCTCTTAA
GAGAATGTGCTGTGTACTAAATACAGGCCACATAGTGTCTGCCTGTTGAAGATCTGGAAACTGCCTCCCCAGATCTGTATTGTATTTGGT
AGGTAAGGGGGTCAGTTTCTTTTTCTCATTGTGTGTTGATAATCTACACACCATCTGTTGGAACCAGGGTGTTATTATGGGGAACTCCTC
CTGTGTACTAGGAGGAGGACCTTAGGGAGACCAAGAGGAGAGAAGCATTTCCTTTGATGAAGTCACATCCTGTCTATGAGCCCACTAATG
CTGTAACATTGGCCTGAAAGAGAGTGTTCTTTAAAAGCCTTTCTCGGCTGTTAGTATAAAAACATGATGGTATCAGCTCTTAGCATGTTT
GCTTGACCCTTATGGAAGGTATAAATCCACAGAACTTCCTTCCCAGAGAACTGGGAAATTGTCCTAGAAATAAACCTTGTACAGTTGAGT
GGACATGGATAAGCAACAATTTGTTACTTTGCAGGATTTGTTCCTTGGTAATTGTTTGGTGTGTCATCCTGTAAATATTCATGATAGTCT
GTTTATATCCTTTTGTATATCGTTGATACTGGATTGGGTAGAAAAATAAATTGGCAATTTAAAAAAATGGAACAGTTAATTG

>6336_6336_2_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000370620_NDC1_chr1_54275419_ENST00000540001_length(amino acids)=297AA_BP=
MNLHIDEQVHRPLDTVSGLLNLSLLYHVWLCGVFLLTTWYVSWILFKIYATEAHVFPVQPPFAEGSDECLPKVLNSNPPPIIKYLALQDL
MLLSQYSPSRRQEVFSLSQPGGHPHNWTAISRECLNLLNGMTQKLILYQEAAATNGRVSSSYPVEPKKLNSPEETAFQTPKSSQMPRPSV
PPLVKTSLFSSKLSTPDVVSPFGTPFGSSVMNRMAGIFDVNTCYGSPQSPQLIRRGPRLWTSASDQQMTEFSNPSPSTSISAEAPRGLHS
GCFFRCPNAYLGIRRSVALSSSIIYRG

--------------------------------------------------------------
>6336_6336_3_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000370622_NDC1_chr1_54275419_ENST00000371429_length(transcript)=4530nt_BP=698nt
GCCCTGACCCTGCCACTTGTGTGAAGTCAGGATCTCCTTTCCCAGGCCTCAGTTGAGTCATCTGTAAAATGAGGAGACTAGAGTAGGGGT
TGGGTAATGTCTAATGGTTGTAATGTCTGTTTTTAACTTGCCCATTTCCATCAGTTTCCGCTAGGCAAAGCTTTGCATATTTAGCTGCTC
AGTTGGAACTAGTAGGAAGACCAAAGAGGATTTTGATATTTGATCCTGATGACCTTTATTCAGGGGTCAATTTCTCCAAGGTACTGAGTA
CTCTTTTAGCTGTCAACAAAGCAACAGAAGATCAGCTATCAGAAAGACCATGTGGACGTTCCTCTTCTCTTAGTGCTGCTAATACTTCTC
AGACAAACCCACAGGGAGCAGTTTCTAGCACAGTTTCAGGGCTGCAAAGGCAGTCAAAGACAGTGGAGATGACGGAAAATGGAAGTCATC
AGTTGATAGTAAAAGCAAGATTCAACTTTAAGCAGACTAATGAGGATGAACTGTCAGTTTGTAAGGGGGACATCATTTACGTCACACGAG
TTGAAGAAGGAGGCTGGTGGGAAGGCACATTAAATGGGAGAACAGGCTGGTTCCCCAGTAATTATGTCCGTGAAATTAAATCCAGTGAGA
GACCTCTCTCCCCAAAAGCCGTCAAAGGATTTGAAACTGCTCCACTTACCAAGAATTATTATACTGTGGCTATATTCCCAAAGCTTGGAT
TAGCACTGCTATGAACCTTCACATAGATGAGCAGGTTCATAGGCCACTTGACACAGTGAGTGGCCTCTTAAATCTCTCGTTACTCTACCA
TGTCTGGCTGTGTGGTGTCTTTCTCCTGACGACTTGGTATGTCTCATGGATACTCTTCAAAATCTATGCCACAGAGGCTCATGTGTTTCC
TGTTCAACCACCATTTGCAGAAGGGTCAGATGAGTGCCTTCCAAAAGTGTTAAATAGCAATCCTCCCCCCATCATAAAGTATTTAGCCTT
GCAGGACCTGATGTTGCTTTCTCAATATTCTCCTTCACGAAGACAAGAAGTTTTCAGCCTCAGCCAACCAGGTGGACATCCCCACAATTG
GACAGCCATTTCAAGGGAGTGTTTGAATCTTTTAAATGGTATGACTCAGAAACTGATTCTCTATCAAGAAGCTGCTGCTACGAATGGGAG
AGTGTCTTCATCTTACCCAGTGGAACCTAAGAAATTAAATTCTCCAGAAGAAACTGCTTTTCAGACACCAAAATCTAGCCAGATGCCTCG
GCCTTCAGTGCCACCATTAGTTAAAACATCACTGTTTTCTTCAAAATTATCTACACCTGATGTTGTGAGCCCATTTGGGACCCCATTTGG
CTCTAGTGTAATGAATCGGATGGCTGGAATTTTTGATGTAAACACCTGCTATGGGTCACCGCAAAGTCCTCAGCTAATAAGAAGGGGGCC
AAGATTGTGGACATCAGCTTCTGATCAGCAAATGACTGAATTTTCTAATCCTTCTCCATCTACCTCTATTAGTGCTGAGGGTAAGACAAT
GAGACAACCCAGTGTGATTTATTCATGGATTCAGAATAAACGTGAACAGATTAAGAATTTCTTGTCAAAACGGGTGCTGATAATGTATTT
TTTCAGTAAGCACCCAGAGGCCTCCATTCAGGCTGTTTTTTCAGATGCCCAAATGCATATTTGGGCATTAGAAGGTCTGTCGCACTTAGT
AGCAGCATCATTTACAGAGGATAGATTTGGAGTTGTCCAGACGACACTACCAGCTATCCTTAATACTTTGTTGACACTGCAAGAGGCAGT
CGACAAGTACTTTAAGCTTCCTCATGCTTCCAGTAAACCACCCCGGATTTCAGGAAGCCTTGTGGACACTTCATATAAAACATTAAGATT
TGCATTCAGAGCATCACTGAAAACTGCCATCTATCGAATAACTACTACATTTGGTGAACATCTGAATGCTGTGCAAGCATCTGCAGAACA
TCAGAAAAGACTTCAACAGTTCTTGGAGTTCAAAGAATAGTTAAGTAATATAAACTGTGTTCATTACACTGCTGATACAACTACAGATGG
GACAGTAAATGTTCAGCATTCTTGGATCAGAAGAAAACGGACTAATTAGATGCTTCCTTTGTCGTGGTGGTTGCTTTGAAAACTATACTT
TAATGGGAGAAATCATGGAAAGAAATTCTCAACAGAATAACTGAAAACTGCCTTTTCTGTACCGATTGCTTTTTGTGTGTGTGGTATAAT
AAAATCTTTATTCAATTTTACAGAAGCATTGATGGCAGTCGAAATGTCTCTAGCTCATATAACTTAATAGTAATAACTAAAAAACTTTTA
GAATTTACTTTTGAAAGGAGGGAAGCCAGTTCTGAAATGAGTATAGGTTGATTTCATAGTCTTCTTAATTAAGAGTTTAGCTCTTTGTAA
ACTCAAAATACATAAACTTTTTAAGTGTAGTTTCATTTACTGAAGGATAAAAATGGTAACAGTGCAGCAATATTCACAAAAAATATTGTC
TAACGGACATATTTTGTTAATCTGTTAGGTTGGGTTTTTGTTTCCAGGGACAAATTAAATTTGTATGATTACCCAAAAAAGGGTCTCAGT
TTACAGATGCTAACTCTATATAAAGGAATGTGGAAAAACTCAGTTCTTAAGTTACAAGATTAAAAATTCACATTTGGTCTTTAAGAAACA
ATTGACTGACATCTATGAATTTATTTTGTATCATGCTAGTAAACACGAAGTATTAATGTATGGGTATTTTCCCAGCTAGTTTTGCTTTCT
TTTTCTGGAGCAAAACATTAAGTGATTGCAGAGTTTTTCAAGCAAGAGAAAAAGGTTTGCAAAAAAACCCAGGAAATGTTCCCTTTTTTC
CCCACCATTCATCTTCATTAGATCAAATTCTGTGAAACTTGTCTGGTCTCTCAAAGGGAGCAGCCTCTGTAGTGTTAAATGGCTAATTAA
AATAGGAAGATCTTTATAGCCAGAAACAACTTAGTCATCAAATAGCAAGTGAAACCAAAACGTCAGAGGGATTACTGTACTTGGAAGTAT
GTTGTGTGTCCCAAATGTGAACGAAGTATTGTTAGAATTTATTAGATCAGCTTCTTTGGAGATCAAAGATTGGAAATCCTAGTCATAGAT
ATTCACTGGACTGGCTTTGGACTGAAATGCTCCTTTGTAATTCTTTTCCTATTGTCTTTTCCTTCTAGTGTCCCAAAATATTTTCTTTAA
AGTCAGCACAGTACTGTATATGAATCTTTAATGTGGTATCATATATGTCTACTTTTGTCTGATTCATCGATGTATTATATCTTTATAATT
GAATATTTTAGCTCCGGGTCCTGTTGCCCCTTCAAGCAGTACATGCCAAATTATAAATAGGTGCTACTGGCCTTGAGCATATCACTGTGG
GACAGTTCCCCAATTGTCAAGTGTTTAGATATGTAGACTATTGCCATTTGTTTTTTTGTTTTGGTTTTGCTTTGTGTCTGAAGCTGAATT
GATTTCTTTTTTTTGAATGTGAAAGTTGAATTTCAAACGTAGTCATTTCTTACAGATGGCCAAGACAGAAAATTGTGGCTAGGTTGACTG
AGAACTGTTGTCTTCCATGTATTAACACAATTAAGCTTTTTATATTCCACTCTCTGTGCTGACCCTGGCTGAGGCATTTTGGGAGACAAG
GACTCTGAATCTTCTGCTTCCATTAAAGAAGAACTGTGATATTCAACATTGGATTTCTGAGAATAAAGATAGGATGATTCCTTTGAACTT
TGACTTACTTGTATAAAATGTCCAGCTAGGTTAGGTTTTTGCCATTTCCTATATACTTTGGGTAAAGCTACATTTGATGAGCAATGTGAA
TGTTTCTGAGAATGTTCATTCCTGTTTTCTCTTAAGAGAATGTGCTGTGTACTAAATACAGGCCACATAGTGTCTGCCTGTTGAAGATCT
GGAAACTGCCTCCCCAGATCTGTATTGTATTTGGTAGGTAAGGGGGTCAGTTTCTTTTTCTCATTGTGTGTTGATAATCTACACACCATC
TGTTGGAACCAGGGTGTTATTATGGGGAACTCCTCCTGTGTACTAGGAGGAGGACCTTAGGGAGACCAAGAGGAGAGAAGCATTTCCTTT
GATGAAGTCACATCCTGTCTATGAGCCCACTAATGCTGTAACATTGGCCTGAAAGAGAGTGTTCTTTAAAAGCCTTTCTCGGCTGTTAGT
ATAAAAACATGATGGTATCAGCTCTTAGCATGTTTGCTTGACCCTTATGGAAGGTATAAATCCACAGAACTTCCTTCCCAGAGAACTGGG
AAATTGTCCTAGAAATAAACCTTGTACAGTTGAGTGGACATGGATAAGCAACAATTTGTTACTTTGCAGGATTTGTTCCTTGGTAATTGT
TTGGTGTGTCATCCTGTAAATATTCATGATAGTCTGTTTATATCCTTTTGTATATCGTTGATACTGGATTGGGTAGAAAAATAAATTGGC
AATTTAAAAAAATGGAACAGTTAATTGAAA

>6336_6336_3_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000370622_NDC1_chr1_54275419_ENST00000371429_length(amino acids)=429AA_BP=
MNLHIDEQVHRPLDTVSGLLNLSLLYHVWLCGVFLLTTWYVSWILFKIYATEAHVFPVQPPFAEGSDECLPKVLNSNPPPIIKYLALQDL
MLLSQYSPSRRQEVFSLSQPGGHPHNWTAISRECLNLLNGMTQKLILYQEAAATNGRVSSSYPVEPKKLNSPEETAFQTPKSSQMPRPSV
PPLVKTSLFSSKLSTPDVVSPFGTPFGSSVMNRMAGIFDVNTCYGSPQSPQLIRRGPRLWTSASDQQMTEFSNPSPSTSISAEGKTMRQP
SVIYSWIQNKREQIKNFLSKRVLIMYFFSKHPEASIQAVFSDAQMHIWALEGLSHLVAASFTEDRFGVVQTTLPAILNTLLTLQEAVDKY
FKLPHASSKPPRISGSLVDTSYKTLRFAFRASLKTAIYRITTTFGEHLNAVQASAEHQKRLQQFLEFKE

--------------------------------------------------------------
>6336_6336_4_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000370622_NDC1_chr1_54275419_ENST00000540001_length(transcript)=4417nt_BP=698nt
GCCCTGACCCTGCCACTTGTGTGAAGTCAGGATCTCCTTTCCCAGGCCTCAGTTGAGTCATCTGTAAAATGAGGAGACTAGAGTAGGGGT
TGGGTAATGTCTAATGGTTGTAATGTCTGTTTTTAACTTGCCCATTTCCATCAGTTTCCGCTAGGCAAAGCTTTGCATATTTAGCTGCTC
AGTTGGAACTAGTAGGAAGACCAAAGAGGATTTTGATATTTGATCCTGATGACCTTTATTCAGGGGTCAATTTCTCCAAGGTACTGAGTA
CTCTTTTAGCTGTCAACAAAGCAACAGAAGATCAGCTATCAGAAAGACCATGTGGACGTTCCTCTTCTCTTAGTGCTGCTAATACTTCTC
AGACAAACCCACAGGGAGCAGTTTCTAGCACAGTTTCAGGGCTGCAAAGGCAGTCAAAGACAGTGGAGATGACGGAAAATGGAAGTCATC
AGTTGATAGTAAAAGCAAGATTCAACTTTAAGCAGACTAATGAGGATGAACTGTCAGTTTGTAAGGGGGACATCATTTACGTCACACGAG
TTGAAGAAGGAGGCTGGTGGGAAGGCACATTAAATGGGAGAACAGGCTGGTTCCCCAGTAATTATGTCCGTGAAATTAAATCCAGTGAGA
GACCTCTCTCCCCAAAAGCCGTCAAAGGATTTGAAACTGCTCCACTTACCAAGAATTATTATACTGTGGCTATATTCCCAAAGCTTGGAT
TAGCACTGCTATGAACCTTCACATAGATGAGCAGGTTCATAGGCCACTTGACACAGTGAGTGGCCTCTTAAATCTCTCGTTACTCTACCA
TGTCTGGCTGTGTGGTGTCTTTCTCCTGACGACTTGGTATGTCTCATGGATACTCTTCAAAATCTATGCCACAGAGGCTCATGTGTTTCC
TGTTCAACCACCATTTGCAGAAGGGTCAGATGAGTGCCTTCCAAAAGTGTTAAATAGCAATCCTCCCCCCATCATAAAGTATTTAGCCTT
GCAGGACCTGATGTTGCTTTCTCAATATTCTCCTTCACGAAGACAAGAAGTTTTCAGCCTCAGCCAACCAGGTGGACATCCCCACAATTG
GACAGCCATTTCAAGGGAGTGTTTGAATCTTTTAAATGGTATGACTCAGAAACTGATTCTCTATCAAGAAGCTGCTGCTACGAATGGGAG
AGTGTCTTCATCTTACCCAGTGGAACCTAAGAAATTAAATTCTCCAGAAGAAACTGCTTTTCAGACACCAAAATCTAGCCAGATGCCTCG
GCCTTCAGTGCCACCATTAGTTAAAACATCACTGTTTTCTTCAAAATTATCTACACCTGATGTTGTGAGCCCATTTGGGACCCCATTTGG
CTCTAGTGTAATGAATCGGATGGCTGGAATTTTTGATGTAAACACCTGCTATGGGTCACCGCAAAGTCCTCAGCTAATAAGAAGGGGGCC
AAGATTGTGGACATCAGCTTCTGATCAGCAAATGACTGAATTTTCTAATCCTTCTCCATCTACCTCTATTAGTGCTGAGGCACCCAGAGG
CCTCCATTCAGGCTGTTTTTTCAGATGCCCAAATGCATATTTGGGCATTAGAAGGTCTGTCGCACTTAGTAGCAGCATCATTTACAGAGG
ATAGATTTGGAGTTGTCCAGACGACACTACCAGCTATCCTTAATACTTTGTTGACACTGCAAGAGGCAGTCGACAAGTACTTTAAGCTTC
CTCATGCTTCCAGTAAACCACCCCGGATTTCAGGAAGCCTTGTGGACACTTCATATAAAACATTAAGATTTGCATTCAGAGCATCACTGA
AAACTGCCATCTATCGAATAACTACTACATTTGGTGAACATCTGAATGCTGTGCAAGCATCTGCAGAACATCAGAAAAGACTTCAACAGT
TCTTGGAGTTCAAAGAATAGTTAAGTAATATAAACTGTGTTCATTACACTGCTGATACAACTACAGATGGGACAGTAAATGTTCAGCATT
CTTGGATCAGAAGAAAACGGACTAATTAGATGCTTCCTTTGTCGTGGTGGTTGCTTTGAAAACTATACTTTAATGGGAGAAATCATGGAA
AGAAATTCTCAACAGAATAACTGAAAACTGCCTTTTCTGTACCGATTGCTTTTTGTGTGTGTGGTATAATAAAATCTTTATTCAATTTTA
CAGAAGCATTGATGGCAGTCGAAATGTCTCTAGCTCATATAACTTAATAGTAATAACTAAAAAACTTTTAGAATTTACTTTTGAAAGGAG
GGAAGCCAGTTCTGAAATGAGTATAGGTTGATTTCATAGTCTTCTTAATTAAGAGTTTAGCTCTTTGTAAACTCAAAATACATAAACTTT
TTAAGTGTAGTTTCATTTACTGAAGGATAAAAATGGTAACAGTGCAGCAATATTCACAAAAAATATTGTCTAACGGACATATTTTGTTAA
TCTGTTAGGTTGGGTTTTTGTTTCCAGGGACAAATTAAATTTGTATGATTACCCAAAAAAGGGTCTCAGTTTACAGATGCTAACTCTATA
TAAAGGAATGTGGAAAAACTCAGTTCTTAAGTTACAAGATTAAAAATTCACATTTGGTCTTTAAGAAACAATTGACTGACATCTATGAAT
TTATTTTGTATCATGCTAGTAAACACGAAGTATTAATGTATGGGTATTTTCCCAGCTAGTTTTGCTTTCTTTTTCTGGAGCAAAACATTA
AGTGATTGCAGAGTTTTTCAAGCAAGAGAAAAAGGTTTGCAAAAAAACCCAGGAAATGTTCCCTTTTTTCCCCACCATTCATCTTCATTA
GATCAAATTCTGTGAAACTTGTCTGGTCTCTCAAAGGGAGCAGCCTCTGTAGTGTTAAATGGCTAATTAAAATAGGAAGATCTTTATAGC
CAGAAACAACTTAGTCATCAAATAGCAAGTGAAACCAAAACGTCAGAGGGATTACTGTACTTGGAAGTATGTTGTGTGTCCCAAATGTGA
ACGAAGTATTGTTAGAATTTATTAGATCAGCTTCTTTGGAGATCAAAGATTGGAAATCCTAGTCATAGATATTCACTGGACTGGCTTTGG
ACTGAAATGCTCCTTTGTAATTCTTTTCCTATTGTCTTTTCCTTCTAGTGTCCCAAAATATTTTCTTTAAAGTCAGCACAGTACTGTATA
TGAATCTTTAATGTGGTATCATATATGTCTACTTTTGTCTGATTCATCGATGTATTATATCTTTATAATTGAATATTTTAGCTCCGGGTC
CTGTTGCCCCTTCAAGCAGTACATGCCAAATTATAAATAGGTGCTACTGGCCTTGAGCATATCACTGTGGGACAGTTCCCCAATTGTCAA
GTGTTTAGATATGTAGACTATTGCCATTTGTTTTTTTGTTTTGGTTTTGCTTTGTGTCTGAAGCTGAATTGATTTCTTTTTTTTGAATGT
GAAAGTTGAATTTCAAACGTAGTCATTTCTTACAGATGGCCAAGACAGAAAATTGTGGCTAGGTTGACTGAGAACTGTTGTCTTCCATGT
ATTAACACAATTAAGCTTTTTATATTCCACTCTCTGTGCTGACCCTGGCTGAGGCATTTTGGGAGACAAGGACTCTGAATCTTCTGCTTC
CATTAAAGAAGAACTGTGATATTCAACATTGGATTTCTGAGAATAAAGATAGGATGATTCCTTTGAACTTTGACTTACTTGTATAAAATG
TCCAGCTAGGTTAGGTTTTTGCCATTTCCTATATACTTTGGGTAAAGCTACATTTGATGAGCAATGTGAATGTTTCTGAGAATGTTCATT
CCTGTTTTCTCTTAAGAGAATGTGCTGTGTACTAAATACAGGCCACATAGTGTCTGCCTGTTGAAGATCTGGAAACTGCCTCCCCAGATC
TGTATTGTATTTGGTAGGTAAGGGGGTCAGTTTCTTTTTCTCATTGTGTGTTGATAATCTACACACCATCTGTTGGAACCAGGGTGTTAT
TATGGGGAACTCCTCCTGTGTACTAGGAGGAGGACCTTAGGGAGACCAAGAGGAGAGAAGCATTTCCTTTGATGAAGTCACATCCTGTCT
ATGAGCCCACTAATGCTGTAACATTGGCCTGAAAGAGAGTGTTCTTTAAAAGCCTTTCTCGGCTGTTAGTATAAAAACATGATGGTATCA
GCTCTTAGCATGTTTGCTTGACCCTTATGGAAGGTATAAATCCACAGAACTTCCTTCCCAGAGAACTGGGAAATTGTCCTAGAAATAAAC
CTTGTACAGTTGAGTGGACATGGATAAGCAACAATTTGTTACTTTGCAGGATTTGTTCCTTGGTAATTGTTTGGTGTGTCATCCTGTAAA
TATTCATGATAGTCTGTTTATATCCTTTTGTATATCGTTGATACTGGATTGGGTAGAAAAATAAATTGGCAATTTAAAAAAATGGAACAG
TTAATTG

>6336_6336_4_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000370622_NDC1_chr1_54275419_ENST00000540001_length(amino acids)=297AA_BP=
MNLHIDEQVHRPLDTVSGLLNLSLLYHVWLCGVFLLTTWYVSWILFKIYATEAHVFPVQPPFAEGSDECLPKVLNSNPPPIIKYLALQDL
MLLSQYSPSRRQEVFSLSQPGGHPHNWTAISRECLNLLNGMTQKLILYQEAAATNGRVSSSYPVEPKKLNSPEETAFQTPKSSQMPRPSV
PPLVKTSLFSSKLSTPDVVSPFGTPFGSSVMNRMAGIFDVNTCYGSPQSPQLIRRGPRLWTSASDQQMTEFSNPSPSTSISAEAPRGLHS
GCFFRCPNAYLGIRRSVALSSSIIYRG

--------------------------------------------------------------
>6336_6336_5_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000535227_NDC1_chr1_54275419_ENST00000371429_length(transcript)=4645nt_BP=813nt
AAAGTTGCAGCCGCCCCTCCCCGCTGGGGCGAGCCTAGCCCAGCTCTCCAGTTTCGCCCTGGTGGCGGCCGCGCTCAGGGCAGGGTCCCA
GCTCCGGCTGGGTTGATCTGTTCCCGCAGCCTTGGCACAGGCTTGCCCGCCCGCTCGCCGGCCCCGTGACTCGGGAGGGCGAACGGCTTC
CAGGAGGCGGCGGCGGCGCGGCTGGAGTGAGGGAGCAGCTGGAGGACAGGCGGGCAGCGGCCGAGCCAGATATTTGATCCTGATGACCTT
TATTCAGGGGTCAATTTCTCCAAGGTACTGAGTACTCTTTTAGCTGTCAACAAAGCAACAGAAGATCAGCTATCAGAAAGACCATGTGGA
CGTTCCTCTTCTCTTAGTGCTGCTAATACTTCTCAGACAAACCCACAGGGAGCAGTTTCTAGCACAGTTTCAGGGCTGCAAAGGCAGTCA
AAGACAGTGGAGATGACGGAAAATGGAAGTCATCAGTTGATAGTAAAAGCAAGATTCAACTTTAAGCAGACTAATGAGGATGAACTGTCA
GTTTGTAAGGGGGACATCATTTACGTCACACGAGTTGAAGAAGGAGGCTGGTGGGAAGGCACATTAAATGGGAGAACAGGCTGGTTCCCC
AGTAATTATGTCCGTGAAATTAAATCCAGTGATGGAGTTTCGCTCTTGTTGCCCGGGCTGGAGTGCAATGGCGCGATCTCAGCTCACCAC
AACCTCTGCCTCCCAGGTTCAAAGAGACCTCTCTCCCCAAAAGCCGTCAAAGGATTTGAAACTGCTCCACTTACCAAGAATTATTATACT
GTGGCTATATTCCCAAAGCTTGGATTAGCACTGCTATGAACCTTCACATAGATGAGCAGGTTCATAGGCCACTTGACACAGTGAGTGGCC
TCTTAAATCTCTCGTTACTCTACCATGTCTGGCTGTGTGGTGTCTTTCTCCTGACGACTTGGTATGTCTCATGGATACTCTTCAAAATCT
ATGCCACAGAGGCTCATGTGTTTCCTGTTCAACCACCATTTGCAGAAGGGTCAGATGAGTGCCTTCCAAAAGTGTTAAATAGCAATCCTC
CCCCCATCATAAAGTATTTAGCCTTGCAGGACCTGATGTTGCTTTCTCAATATTCTCCTTCACGAAGACAAGAAGTTTTCAGCCTCAGCC
AACCAGGTGGACATCCCCACAATTGGACAGCCATTTCAAGGGAGTGTTTGAATCTTTTAAATGGTATGACTCAGAAACTGATTCTCTATC
AAGAAGCTGCTGCTACGAATGGGAGAGTGTCTTCATCTTACCCAGTGGAACCTAAGAAATTAAATTCTCCAGAAGAAACTGCTTTTCAGA
CACCAAAATCTAGCCAGATGCCTCGGCCTTCAGTGCCACCATTAGTTAAAACATCACTGTTTTCTTCAAAATTATCTACACCTGATGTTG
TGAGCCCATTTGGGACCCCATTTGGCTCTAGTGTAATGAATCGGATGGCTGGAATTTTTGATGTAAACACCTGCTATGGGTCACCGCAAA
GTCCTCAGCTAATAAGAAGGGGGCCAAGATTGTGGACATCAGCTTCTGATCAGCAAATGACTGAATTTTCTAATCCTTCTCCATCTACCT
CTATTAGTGCTGAGGGTAAGACAATGAGACAACCCAGTGTGATTTATTCATGGATTCAGAATAAACGTGAACAGATTAAGAATTTCTTGT
CAAAACGGGTGCTGATAATGTATTTTTTCAGTAAGCACCCAGAGGCCTCCATTCAGGCTGTTTTTTCAGATGCCCAAATGCATATTTGGG
CATTAGAAGGTCTGTCGCACTTAGTAGCAGCATCATTTACAGAGGATAGATTTGGAGTTGTCCAGACGACACTACCAGCTATCCTTAATA
CTTTGTTGACACTGCAAGAGGCAGTCGACAAGTACTTTAAGCTTCCTCATGCTTCCAGTAAACCACCCCGGATTTCAGGAAGCCTTGTGG
ACACTTCATATAAAACATTAAGATTTGCATTCAGAGCATCACTGAAAACTGCCATCTATCGAATAACTACTACATTTGGTGAACATCTGA
ATGCTGTGCAAGCATCTGCAGAACATCAGAAAAGACTTCAACAGTTCTTGGAGTTCAAAGAATAGTTAAGTAATATAAACTGTGTTCATT
ACACTGCTGATACAACTACAGATGGGACAGTAAATGTTCAGCATTCTTGGATCAGAAGAAAACGGACTAATTAGATGCTTCCTTTGTCGT
GGTGGTTGCTTTGAAAACTATACTTTAATGGGAGAAATCATGGAAAGAAATTCTCAACAGAATAACTGAAAACTGCCTTTTCTGTACCGA
TTGCTTTTTGTGTGTGTGGTATAATAAAATCTTTATTCAATTTTACAGAAGCATTGATGGCAGTCGAAATGTCTCTAGCTCATATAACTT
AATAGTAATAACTAAAAAACTTTTAGAATTTACTTTTGAAAGGAGGGAAGCCAGTTCTGAAATGAGTATAGGTTGATTTCATAGTCTTCT
TAATTAAGAGTTTAGCTCTTTGTAAACTCAAAATACATAAACTTTTTAAGTGTAGTTTCATTTACTGAAGGATAAAAATGGTAACAGTGC
AGCAATATTCACAAAAAATATTGTCTAACGGACATATTTTGTTAATCTGTTAGGTTGGGTTTTTGTTTCCAGGGACAAATTAAATTTGTA
TGATTACCCAAAAAAGGGTCTCAGTTTACAGATGCTAACTCTATATAAAGGAATGTGGAAAAACTCAGTTCTTAAGTTACAAGATTAAAA
ATTCACATTTGGTCTTTAAGAAACAATTGACTGACATCTATGAATTTATTTTGTATCATGCTAGTAAACACGAAGTATTAATGTATGGGT
ATTTTCCCAGCTAGTTTTGCTTTCTTTTTCTGGAGCAAAACATTAAGTGATTGCAGAGTTTTTCAAGCAAGAGAAAAAGGTTTGCAAAAA
AACCCAGGAAATGTTCCCTTTTTTCCCCACCATTCATCTTCATTAGATCAAATTCTGTGAAACTTGTCTGGTCTCTCAAAGGGAGCAGCC
TCTGTAGTGTTAAATGGCTAATTAAAATAGGAAGATCTTTATAGCCAGAAACAACTTAGTCATCAAATAGCAAGTGAAACCAAAACGTCA
GAGGGATTACTGTACTTGGAAGTATGTTGTGTGTCCCAAATGTGAACGAAGTATTGTTAGAATTTATTAGATCAGCTTCTTTGGAGATCA
AAGATTGGAAATCCTAGTCATAGATATTCACTGGACTGGCTTTGGACTGAAATGCTCCTTTGTAATTCTTTTCCTATTGTCTTTTCCTTC
TAGTGTCCCAAAATATTTTCTTTAAAGTCAGCACAGTACTGTATATGAATCTTTAATGTGGTATCATATATGTCTACTTTTGTCTGATTC
ATCGATGTATTATATCTTTATAATTGAATATTTTAGCTCCGGGTCCTGTTGCCCCTTCAAGCAGTACATGCCAAATTATAAATAGGTGCT
ACTGGCCTTGAGCATATCACTGTGGGACAGTTCCCCAATTGTCAAGTGTTTAGATATGTAGACTATTGCCATTTGTTTTTTTGTTTTGGT
TTTGCTTTGTGTCTGAAGCTGAATTGATTTCTTTTTTTTGAATGTGAAAGTTGAATTTCAAACGTAGTCATTTCTTACAGATGGCCAAGA
CAGAAAATTGTGGCTAGGTTGACTGAGAACTGTTGTCTTCCATGTATTAACACAATTAAGCTTTTTATATTCCACTCTCTGTGCTGACCC
TGGCTGAGGCATTTTGGGAGACAAGGACTCTGAATCTTCTGCTTCCATTAAAGAAGAACTGTGATATTCAACATTGGATTTCTGAGAATA
AAGATAGGATGATTCCTTTGAACTTTGACTTACTTGTATAAAATGTCCAGCTAGGTTAGGTTTTTGCCATTTCCTATATACTTTGGGTAA
AGCTACATTTGATGAGCAATGTGAATGTTTCTGAGAATGTTCATTCCTGTTTTCTCTTAAGAGAATGTGCTGTGTACTAAATACAGGCCA
CATAGTGTCTGCCTGTTGAAGATCTGGAAACTGCCTCCCCAGATCTGTATTGTATTTGGTAGGTAAGGGGGTCAGTTTCTTTTTCTCATT
GTGTGTTGATAATCTACACACCATCTGTTGGAACCAGGGTGTTATTATGGGGAACTCCTCCTGTGTACTAGGAGGAGGACCTTAGGGAGA
CCAAGAGGAGAGAAGCATTTCCTTTGATGAAGTCACATCCTGTCTATGAGCCCACTAATGCTGTAACATTGGCCTGAAAGAGAGTGTTCT
TTAAAAGCCTTTCTCGGCTGTTAGTATAAAAACATGATGGTATCAGCTCTTAGCATGTTTGCTTGACCCTTATGGAAGGTATAAATCCAC
AGAACTTCCTTCCCAGAGAACTGGGAAATTGTCCTAGAAATAAACCTTGTACAGTTGAGTGGACATGGATAAGCAACAATTTGTTACTTT
GCAGGATTTGTTCCTTGGTAATTGTTTGGTGTGTCATCCTGTAAATATTCATGATAGTCTGTTTATATCCTTTTGTATATCGTTGATACT
GGATTGGGTAGAAAAATAAATTGGCAATTTAAAAAAATGGAACAGTTAATTGAAA

>6336_6336_5_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000535227_NDC1_chr1_54275419_ENST00000371429_length(amino acids)=429AA_BP=
MNLHIDEQVHRPLDTVSGLLNLSLLYHVWLCGVFLLTTWYVSWILFKIYATEAHVFPVQPPFAEGSDECLPKVLNSNPPPIIKYLALQDL
MLLSQYSPSRRQEVFSLSQPGGHPHNWTAISRECLNLLNGMTQKLILYQEAAATNGRVSSSYPVEPKKLNSPEETAFQTPKSSQMPRPSV
PPLVKTSLFSSKLSTPDVVSPFGTPFGSSVMNRMAGIFDVNTCYGSPQSPQLIRRGPRLWTSASDQQMTEFSNPSPSTSISAEGKTMRQP
SVIYSWIQNKREQIKNFLSKRVLIMYFFSKHPEASIQAVFSDAQMHIWALEGLSHLVAASFTEDRFGVVQTTLPAILNTLLTLQEAVDKY
FKLPHASSKPPRISGSLVDTSYKTLRFAFRASLKTAIYRITTTFGEHLNAVQASAEHQKRLQQFLEFKE

--------------------------------------------------------------
>6336_6336_6_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000535227_NDC1_chr1_54275419_ENST00000540001_length(transcript)=4532nt_BP=813nt
AAAGTTGCAGCCGCCCCTCCCCGCTGGGGCGAGCCTAGCCCAGCTCTCCAGTTTCGCCCTGGTGGCGGCCGCGCTCAGGGCAGGGTCCCA
GCTCCGGCTGGGTTGATCTGTTCCCGCAGCCTTGGCACAGGCTTGCCCGCCCGCTCGCCGGCCCCGTGACTCGGGAGGGCGAACGGCTTC
CAGGAGGCGGCGGCGGCGCGGCTGGAGTGAGGGAGCAGCTGGAGGACAGGCGGGCAGCGGCCGAGCCAGATATTTGATCCTGATGACCTT
TATTCAGGGGTCAATTTCTCCAAGGTACTGAGTACTCTTTTAGCTGTCAACAAAGCAACAGAAGATCAGCTATCAGAAAGACCATGTGGA
CGTTCCTCTTCTCTTAGTGCTGCTAATACTTCTCAGACAAACCCACAGGGAGCAGTTTCTAGCACAGTTTCAGGGCTGCAAAGGCAGTCA
AAGACAGTGGAGATGACGGAAAATGGAAGTCATCAGTTGATAGTAAAAGCAAGATTCAACTTTAAGCAGACTAATGAGGATGAACTGTCA
GTTTGTAAGGGGGACATCATTTACGTCACACGAGTTGAAGAAGGAGGCTGGTGGGAAGGCACATTAAATGGGAGAACAGGCTGGTTCCCC
AGTAATTATGTCCGTGAAATTAAATCCAGTGATGGAGTTTCGCTCTTGTTGCCCGGGCTGGAGTGCAATGGCGCGATCTCAGCTCACCAC
AACCTCTGCCTCCCAGGTTCAAAGAGACCTCTCTCCCCAAAAGCCGTCAAAGGATTTGAAACTGCTCCACTTACCAAGAATTATTATACT
GTGGCTATATTCCCAAAGCTTGGATTAGCACTGCTATGAACCTTCACATAGATGAGCAGGTTCATAGGCCACTTGACACAGTGAGTGGCC
TCTTAAATCTCTCGTTACTCTACCATGTCTGGCTGTGTGGTGTCTTTCTCCTGACGACTTGGTATGTCTCATGGATACTCTTCAAAATCT
ATGCCACAGAGGCTCATGTGTTTCCTGTTCAACCACCATTTGCAGAAGGGTCAGATGAGTGCCTTCCAAAAGTGTTAAATAGCAATCCTC
CCCCCATCATAAAGTATTTAGCCTTGCAGGACCTGATGTTGCTTTCTCAATATTCTCCTTCACGAAGACAAGAAGTTTTCAGCCTCAGCC
AACCAGGTGGACATCCCCACAATTGGACAGCCATTTCAAGGGAGTGTTTGAATCTTTTAAATGGTATGACTCAGAAACTGATTCTCTATC
AAGAAGCTGCTGCTACGAATGGGAGAGTGTCTTCATCTTACCCAGTGGAACCTAAGAAATTAAATTCTCCAGAAGAAACTGCTTTTCAGA
CACCAAAATCTAGCCAGATGCCTCGGCCTTCAGTGCCACCATTAGTTAAAACATCACTGTTTTCTTCAAAATTATCTACACCTGATGTTG
TGAGCCCATTTGGGACCCCATTTGGCTCTAGTGTAATGAATCGGATGGCTGGAATTTTTGATGTAAACACCTGCTATGGGTCACCGCAAA
GTCCTCAGCTAATAAGAAGGGGGCCAAGATTGTGGACATCAGCTTCTGATCAGCAAATGACTGAATTTTCTAATCCTTCTCCATCTACCT
CTATTAGTGCTGAGGCACCCAGAGGCCTCCATTCAGGCTGTTTTTTCAGATGCCCAAATGCATATTTGGGCATTAGAAGGTCTGTCGCAC
TTAGTAGCAGCATCATTTACAGAGGATAGATTTGGAGTTGTCCAGACGACACTACCAGCTATCCTTAATACTTTGTTGACACTGCAAGAG
GCAGTCGACAAGTACTTTAAGCTTCCTCATGCTTCCAGTAAACCACCCCGGATTTCAGGAAGCCTTGTGGACACTTCATATAAAACATTA
AGATTTGCATTCAGAGCATCACTGAAAACTGCCATCTATCGAATAACTACTACATTTGGTGAACATCTGAATGCTGTGCAAGCATCTGCA
GAACATCAGAAAAGACTTCAACAGTTCTTGGAGTTCAAAGAATAGTTAAGTAATATAAACTGTGTTCATTACACTGCTGATACAACTACA
GATGGGACAGTAAATGTTCAGCATTCTTGGATCAGAAGAAAACGGACTAATTAGATGCTTCCTTTGTCGTGGTGGTTGCTTTGAAAACTA
TACTTTAATGGGAGAAATCATGGAAAGAAATTCTCAACAGAATAACTGAAAACTGCCTTTTCTGTACCGATTGCTTTTTGTGTGTGTGGT
ATAATAAAATCTTTATTCAATTTTACAGAAGCATTGATGGCAGTCGAAATGTCTCTAGCTCATATAACTTAATAGTAATAACTAAAAAAC
TTTTAGAATTTACTTTTGAAAGGAGGGAAGCCAGTTCTGAAATGAGTATAGGTTGATTTCATAGTCTTCTTAATTAAGAGTTTAGCTCTT
TGTAAACTCAAAATACATAAACTTTTTAAGTGTAGTTTCATTTACTGAAGGATAAAAATGGTAACAGTGCAGCAATATTCACAAAAAATA
TTGTCTAACGGACATATTTTGTTAATCTGTTAGGTTGGGTTTTTGTTTCCAGGGACAAATTAAATTTGTATGATTACCCAAAAAAGGGTC
TCAGTTTACAGATGCTAACTCTATATAAAGGAATGTGGAAAAACTCAGTTCTTAAGTTACAAGATTAAAAATTCACATTTGGTCTTTAAG
AAACAATTGACTGACATCTATGAATTTATTTTGTATCATGCTAGTAAACACGAAGTATTAATGTATGGGTATTTTCCCAGCTAGTTTTGC
TTTCTTTTTCTGGAGCAAAACATTAAGTGATTGCAGAGTTTTTCAAGCAAGAGAAAAAGGTTTGCAAAAAAACCCAGGAAATGTTCCCTT
TTTTCCCCACCATTCATCTTCATTAGATCAAATTCTGTGAAACTTGTCTGGTCTCTCAAAGGGAGCAGCCTCTGTAGTGTTAAATGGCTA
ATTAAAATAGGAAGATCTTTATAGCCAGAAACAACTTAGTCATCAAATAGCAAGTGAAACCAAAACGTCAGAGGGATTACTGTACTTGGA
AGTATGTTGTGTGTCCCAAATGTGAACGAAGTATTGTTAGAATTTATTAGATCAGCTTCTTTGGAGATCAAAGATTGGAAATCCTAGTCA
TAGATATTCACTGGACTGGCTTTGGACTGAAATGCTCCTTTGTAATTCTTTTCCTATTGTCTTTTCCTTCTAGTGTCCCAAAATATTTTC
TTTAAAGTCAGCACAGTACTGTATATGAATCTTTAATGTGGTATCATATATGTCTACTTTTGTCTGATTCATCGATGTATTATATCTTTA
TAATTGAATATTTTAGCTCCGGGTCCTGTTGCCCCTTCAAGCAGTACATGCCAAATTATAAATAGGTGCTACTGGCCTTGAGCATATCAC
TGTGGGACAGTTCCCCAATTGTCAAGTGTTTAGATATGTAGACTATTGCCATTTGTTTTTTTGTTTTGGTTTTGCTTTGTGTCTGAAGCT
GAATTGATTTCTTTTTTTTGAATGTGAAAGTTGAATTTCAAACGTAGTCATTTCTTACAGATGGCCAAGACAGAAAATTGTGGCTAGGTT
GACTGAGAACTGTTGTCTTCCATGTATTAACACAATTAAGCTTTTTATATTCCACTCTCTGTGCTGACCCTGGCTGAGGCATTTTGGGAG
ACAAGGACTCTGAATCTTCTGCTTCCATTAAAGAAGAACTGTGATATTCAACATTGGATTTCTGAGAATAAAGATAGGATGATTCCTTTG
AACTTTGACTTACTTGTATAAAATGTCCAGCTAGGTTAGGTTTTTGCCATTTCCTATATACTTTGGGTAAAGCTACATTTGATGAGCAAT
GTGAATGTTTCTGAGAATGTTCATTCCTGTTTTCTCTTAAGAGAATGTGCTGTGTACTAAATACAGGCCACATAGTGTCTGCCTGTTGAA
GATCTGGAAACTGCCTCCCCAGATCTGTATTGTATTTGGTAGGTAAGGGGGTCAGTTTCTTTTTCTCATTGTGTGTTGATAATCTACACA
CCATCTGTTGGAACCAGGGTGTTATTATGGGGAACTCCTCCTGTGTACTAGGAGGAGGACCTTAGGGAGACCAAGAGGAGAGAAGCATTT
CCTTTGATGAAGTCACATCCTGTCTATGAGCCCACTAATGCTGTAACATTGGCCTGAAAGAGAGTGTTCTTTAAAAGCCTTTCTCGGCTG
TTAGTATAAAAACATGATGGTATCAGCTCTTAGCATGTTTGCTTGACCCTTATGGAAGGTATAAATCCACAGAACTTCCTTCCCAGAGAA
CTGGGAAATTGTCCTAGAAATAAACCTTGTACAGTTGAGTGGACATGGATAAGCAACAATTTGTTACTTTGCAGGATTTGTTCCTTGGTA
ATTGTTTGGTGTGTCATCCTGTAAATATTCATGATAGTCTGTTTATATCCTTTTGTATATCGTTGATACTGGATTGGGTAGAAAAATAAA
TTGGCAATTTAAAAAAATGGAACAGTTAATTG

>6336_6336_6_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000535227_NDC1_chr1_54275419_ENST00000540001_length(amino acids)=297AA_BP=
MNLHIDEQVHRPLDTVSGLLNLSLLYHVWLCGVFLLTTWYVSWILFKIYATEAHVFPVQPPFAEGSDECLPKVLNSNPPPIIKYLALQDL
MLLSQYSPSRRQEVFSLSQPGGHPHNWTAISRECLNLLNGMTQKLILYQEAAATNGRVSSSYPVEPKKLNSPEETAFQTPKSSQMPRPSV
PPLVKTSLFSSKLSTPDVVSPFGTPFGSSVMNRMAGIFDVNTCYGSPQSPQLIRRGPRLWTSASDQQMTEFSNPSPSTSISAEAPRGLHS
GCFFRCPNAYLGIRRSVALSSSIIYRG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARHGEF6-TMEM48


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGEF6-TMEM48


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGEF6-TMEM48


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARHGEF6C3501611Mental Retardation, X-Linked Nonsyndromic4CLINGEN
HgeneARHGEF6C1136249Mental Retardation, X-Linked1GENOMICS_ENGLAND
HgeneARHGEF6C1845526Mental Retardation, X-Linked 461GENOMICS_ENGLAND
HgeneARHGEF6C2931498Mental Retardation, X-Linked 11ORPHANET
TgeneC0043094Weight Gain1CTD_human