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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CD34-UFL1 (FusionGDB2 ID:HG947TG23376)

Fusion Gene Summary for CD34-UFL1

check button Fusion gene summary
Fusion gene informationFusion gene name: CD34-UFL1
Fusion gene ID: hg947tg23376
HgeneTgene
Gene symbol

CD34

UFL1

Gene ID

947

23376

Gene nameCD34 moleculeUFM1 specific ligase 1
Synonyms-KIAA0776|Maxer|NLBP|RCAD
Cytomap('CD34')('UFL1')

1q32.2

6q16.1

Type of geneprotein-codingprotein-coding
Descriptionhematopoietic progenitor cell antigen CD34CD34 antigenE3 UFM1-protein ligase 1E3 UFM1-protein transferase 1LZAP-binding proteinRegulator of CDK5RAP3 and DDRGK1multiple alpha-helix protein located at ERnovel LZAP-binding proteinregulator of C53/LZAP and DDRGK1
Modification date2020031320200313
UniProtAcc

P28906

.
Ensembl transtripts involved in fusion geneENST00000310833, ENST00000356522, 
ENST00000367036, ENST00000485761, 
ENST00000537704, 
Fusion gene scores* DoF score6 X 6 X 1=361 X 1 X 1=1
# samples 61
** MAII scorelog2(6/36*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: CD34 [Title/Abstract] AND UFL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCD34(208070192)-UFL1(97003090), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD34

GO:0001894

tissue homeostasis

12939361

HgeneCD34

GO:0001935

endothelial cell proliferation

21835908

HgeneCD34

GO:0008217

regulation of blood pressure

17505307

HgeneCD34

GO:0030195

negative regulation of blood coagulation

17505307

HgeneCD34

GO:0032720

negative regulation of tumor necrosis factor production

17505307

HgeneCD34

GO:0032733

positive regulation of interleukin-10 production

17505307

HgeneCD34

GO:0038001

paracrine signaling

21835908

HgeneCD34

GO:0042482

positive regulation of odontogenesis

12939361

HgeneCD34

GO:0045019

negative regulation of nitric oxide biosynthetic process

17505307

HgeneCD34

GO:0045766

positive regulation of angiogenesis

12939361|21835908

HgeneCD34

GO:0071636

positive regulation of transforming growth factor beta production

17505307

HgeneCD34

GO:0071657

positive regulation of granulocyte colony-stimulating factor production

9815891

HgeneCD34

GO:0071971

extracellular exosome assembly

21835908

HgeneCD34

GO:0098609

cell-cell adhesion

15249540

HgeneCD34

GO:1900035

negative regulation of cellular response to heat

17505307

HgeneCD34

GO:1900038

negative regulation of cellular response to hypoxia

17505307

HgeneCD34

GO:1900168

positive regulation of glial cell-derived neurotrophic factor secretion

17505307

HgeneCD34

GO:1901215

negative regulation of neuron death

17505307

HgeneCD34

GO:2001214

positive regulation of vasculogenesis

12939361

TgeneUFL1

GO:0031397

negative regulation of protein ubiquitination

20164180

TgeneUFL1

GO:0033146

regulation of intracellular estrogen receptor signaling pathway

25219498

TgeneUFL1

GO:0034976

response to endoplasmic reticulum stress

23152784

TgeneUFL1

GO:0071569

protein ufmylation

20018847

TgeneUFL1

GO:1990592

protein K69-linked ufmylation

25219498



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for CD34-UFL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CD34-UFL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for CD34-UFL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:208070192/:97003090)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD34

P28906

.
FUNCTION: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CD34-UFL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CD34-UFL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CD34-UFL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CD34-UFL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCD34C0007621Neoplastic Cell Transformation1CTD_human
HgeneCD34C0033975Psychotic Disorders1PSYGENET
HgeneCD34C0041696Unipolar Depression1PSYGENET
HgeneCD34C0349204Nonorganic psychosis1PSYGENET
HgeneCD34C1269683Major Depressive Disorder1PSYGENET
HgeneCD34C2239176Liver carcinoma1CTD_human