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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CD34-UFL1 (FusionGDB2 ID:HG947TG23376) |
Fusion Gene Summary for CD34-UFL1 |
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Fusion gene information | Fusion gene name: CD34-UFL1 | Fusion gene ID: hg947tg23376 | Hgene | Tgene | Gene symbol | CD34 | UFL1 | Gene ID | 947 | 23376 |
Gene name | CD34 molecule | UFM1 specific ligase 1 | |
Synonyms | - | KIAA0776|Maxer|NLBP|RCAD | |
Cytomap | ('CD34')('UFL1') 1q32.2 | 6q16.1 | |
Type of gene | protein-coding | protein-coding | |
Description | hematopoietic progenitor cell antigen CD34CD34 antigen | E3 UFM1-protein ligase 1E3 UFM1-protein transferase 1LZAP-binding proteinRegulator of CDK5RAP3 and DDRGK1multiple alpha-helix protein located at ERnovel LZAP-binding proteinregulator of C53/LZAP and DDRGK1 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | P28906 | . | |
Ensembl transtripts involved in fusion gene | ENST00000310833, ENST00000356522, ENST00000367036, ENST00000485761, ENST00000537704, | ||
Fusion gene scores | * DoF score | 6 X 6 X 1=36 | 1 X 1 X 1=1 |
# samples | 6 | 1 | |
** MAII score | log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: CD34 [Title/Abstract] AND UFL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CD34(208070192)-UFL1(97003090), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CD34 | GO:0001894 | tissue homeostasis | 12939361 |
Hgene | CD34 | GO:0001935 | endothelial cell proliferation | 21835908 |
Hgene | CD34 | GO:0008217 | regulation of blood pressure | 17505307 |
Hgene | CD34 | GO:0030195 | negative regulation of blood coagulation | 17505307 |
Hgene | CD34 | GO:0032720 | negative regulation of tumor necrosis factor production | 17505307 |
Hgene | CD34 | GO:0032733 | positive regulation of interleukin-10 production | 17505307 |
Hgene | CD34 | GO:0038001 | paracrine signaling | 21835908 |
Hgene | CD34 | GO:0042482 | positive regulation of odontogenesis | 12939361 |
Hgene | CD34 | GO:0045019 | negative regulation of nitric oxide biosynthetic process | 17505307 |
Hgene | CD34 | GO:0045766 | positive regulation of angiogenesis | 12939361|21835908 |
Hgene | CD34 | GO:0071636 | positive regulation of transforming growth factor beta production | 17505307 |
Hgene | CD34 | GO:0071657 | positive regulation of granulocyte colony-stimulating factor production | 9815891 |
Hgene | CD34 | GO:0071971 | extracellular exosome assembly | 21835908 |
Hgene | CD34 | GO:0098609 | cell-cell adhesion | 15249540 |
Hgene | CD34 | GO:1900035 | negative regulation of cellular response to heat | 17505307 |
Hgene | CD34 | GO:1900038 | negative regulation of cellular response to hypoxia | 17505307 |
Hgene | CD34 | GO:1900168 | positive regulation of glial cell-derived neurotrophic factor secretion | 17505307 |
Hgene | CD34 | GO:1901215 | negative regulation of neuron death | 17505307 |
Hgene | CD34 | GO:2001214 | positive regulation of vasculogenesis | 12939361 |
Tgene | UFL1 | GO:0031397 | negative regulation of protein ubiquitination | 20164180 |
Tgene | UFL1 | GO:0033146 | regulation of intracellular estrogen receptor signaling pathway | 25219498 |
Tgene | UFL1 | GO:0034976 | response to endoplasmic reticulum stress | 23152784 |
Tgene | UFL1 | GO:0071569 | protein ufmylation | 20018847 |
Tgene | UFL1 | GO:1990592 | protein K69-linked ufmylation | 25219498 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for CD34-UFL1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CD34-UFL1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for CD34-UFL1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:208070192/:97003090) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
CD34 | . |
FUNCTION: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CD34-UFL1 |
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Fusion Gene PPI Analysis for CD34-UFL1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CD34-UFL1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CD34-UFL1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CD34 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Hgene | CD34 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Hgene | CD34 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Hgene | CD34 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
Hgene | CD34 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Hgene | CD34 | C2239176 | Liver carcinoma | 1 | CTD_human |