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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PGS1-CXCR5 (FusionGDB2 ID:HG9489TG643)

Fusion Gene Summary for PGS1-CXCR5

check button Fusion gene summary
Fusion gene informationFusion gene name: PGS1-CXCR5
Fusion gene ID: hg9489tg643
HgeneTgene
Gene symbol

PGS1

CXCR5

Gene ID

9489

643

Gene namephosphatidylglycerophosphate synthase 1C-X-C motif chemokine receptor 5
Synonyms-BLR1|CD185|MDR15
Cytomap('PGS1')('CXCR5')

17q25.3

11q23.3

Type of geneprotein-codingprotein-coding
DescriptionCDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrialPGP synthase 1C-X-C chemokine receptor type 5Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5)Burkitt lymphoma receptor 1, GTP-binding proteinCXC-R5CXCR-5MDR-15chemokine (C-X-C motif) receptor 5monocyte-derived receptor 15
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000588281, ENST00000262764, 
ENST00000329897, 
Fusion gene scores* DoF score11 X 9 X 6=59412 X 4 X 8=384
# samples 1412
** MAII scorelog2(14/594*10)=-2.0850361038558
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/384*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PGS1 [Title/Abstract] AND CXCR5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPGS1(76395618)-CXCR5(118754561), # samples:2
PGS1(76395618)-CXCR5(118764305), # samples:2
Anticipated loss of major functional domain due to fusion event.PGS1-CXCR5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PGS1-CXCR5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PGS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CXCR5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-D1-A3JP-01APGS1chr17

76395618

+CXCR5chr11

118754561

+
ChimerDB4UCECTCGA-D1-A3JP-01APGS1chr17

76395618

-CXCR5chr11

118764305

+
ChimerDB4UCECTCGA-D1-A3JP-01APGS1chr17

76395618

+CXCR5chr11

118764305

+


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Fusion Gene ORF analysis for PGS1-CXCR5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000588281ENST00000292174PGS1chr17

76395618

+CXCR5chr11

118764305

+
3UTR-5UTRENST00000588281ENST00000292174PGS1chr17

76395618

+CXCR5chr11

118754561

+
5CDS-5UTRENST00000262764ENST00000292174PGS1chr17

76395618

+CXCR5chr11

118754561

+
5CDS-5UTRENST00000329897ENST00000292174PGS1chr17

76395618

+CXCR5chr11

118754561

+
In-frameENST00000262764ENST00000292174PGS1chr17

76395618

+CXCR5chr11

118764305

+
In-frameENST00000329897ENST00000292174PGS1chr17

76395618

+CXCR5chr11

118764305

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262764PGS1chr1776395618+ENST00000292174CXCR5chr11118764305+49317277361794352
ENST00000329897PGS1chr1776395618+ENST00000292174CXCR5chr11118764305+47935895981656352

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262764ENST00000292174PGS1chr1776395618+CXCR5chr11118764305+0.090533830.9094662
ENST00000329897ENST00000292174PGS1chr1776395618+CXCR5chr11118764305+0.0928163750.9071836

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Fusion Genomic Features for PGS1-CXCR5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PGS1chr1776395618+CXCR5chr11118764304+2.26E-050.99997735
PGS1chr1776395618+CXCR5chr11118764304+2.26E-050.99997735

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PGS1-CXCR5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:76395618/chr11:118754561)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGS1chr17:76395618chr11:118764305ENST00000262764+510124_131233665.3333333333334Nucleotide bindingATP
TgeneCXCR5chr17:76395618chr11:118764305ENST0000029217402110_12417373.0Topological domainExtracellular
TgeneCXCR5chr17:76395618chr11:118764305ENST0000029217402146_16717373.0Topological domainCytoplasmic
TgeneCXCR5chr17:76395618chr11:118764305ENST0000029217402189_21917373.0Topological domainExtracellular
TgeneCXCR5chr17:76395618chr11:118764305ENST0000029217402241_25917373.0Topological domainCytoplasmic
TgeneCXCR5chr17:76395618chr11:118764305ENST0000029217402281_30417373.0Topological domainExtracellular
TgeneCXCR5chr17:76395618chr11:118764305ENST0000029217402326_37217373.0Topological domainCytoplasmic
TgeneCXCR5chr17:76395618chr11:118764305ENST000002921740277_8817373.0Topological domainCytoplasmic
TgeneCXCR5chr17:76395618chr11:118764305ENST0000029217402125_14517373.0TransmembraneHelical%3B Name%3D3
TgeneCXCR5chr17:76395618chr11:118764305ENST0000029217402168_18817373.0TransmembraneHelical%3B Name%3D4
TgeneCXCR5chr17:76395618chr11:118764305ENST0000029217402220_24017373.0TransmembraneHelical%3B Name%3D5
TgeneCXCR5chr17:76395618chr11:118764305ENST0000029217402260_28017373.0TransmembraneHelical%3B Name%3D6
TgeneCXCR5chr17:76395618chr11:118764305ENST0000029217402305_32517373.0TransmembraneHelical%3B Name%3D7
TgeneCXCR5chr17:76395618chr11:118764305ENST000002921740256_7617373.0TransmembraneHelical%3B Name%3D1
TgeneCXCR5chr17:76395618chr11:118764305ENST000002921740289_10917373.0TransmembraneHelical%3B Name%3D2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGS1chr17:76395618chr11:118764305ENST00000262764+510215_241233665.3333333333334DomainPLD phosphodiesterase 1
HgenePGS1chr17:76395618chr11:118764305ENST00000262764+510460_493233665.3333333333334DomainPLD phosphodiesterase 2
TgeneCXCR5chr17:76395618chr11:118764305ENST00000292174021_5517373.0Topological domainExtracellular


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Fusion Gene Sequence for PGS1-CXCR5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>64665_64665_1_PGS1-CXCR5_PGS1_chr17_76395618_ENST00000262764_CXCR5_chr11_118764305_ENST00000292174_length(transcript)=4931nt_BP=727nt
AGCGGAAGCGGAAGCGGCGAGTCTCCATGGCGGTGGCGGCGGCAGCTGCGGCGGGACCCGTGTTCTGGAGGCGACTGCTGGGCCTCCTGC
CTGGCCGCCCAGGGCTGGCCGCGCTCCTGGGACGCCTGTCCGACCGCCTCGGCAGGAACCGGGACCGCCAGCGCAGGAGGTCACCATGGC
TGTTATTGGCTCCCTTGCTGTCCCCAGCTGTTCCCCAGGTCACCTCCCCACCTTGCTGCCTGTGTCCAGAAGGCGTGCACCGGTTCCAGT
GGATCAGAAACCTGGTTCCAGAATTTGGAGTCTCCAGTTCTCACGTTAGGGTGCTTTCTTCCCCGGCAGAGTTTTTCGAGCTCATGAAGG
GGCAGATAAGAGTAGCCAAGAGGCGGGTCGTGATGGCATCCCTCTACCTGGGGACAGGTCCTTTGGAACAGGAGCTGGTGGACTGCCTGG
AAAGTACTCTAGAAAAGTCACTCCAAGCAAAGTTTCCTTCAAATCTCAAGGTCTCCATTCTCTTAGACTTCACGCGGGGCTCACGAGGCC
GGAAGAACTCCCGCACAATGCTGCTCCCACTCCTGCGGAGGTTCCCAGAGCAGGTCCGAGTCTCCCTCTTTCACACGCCGCACCTCCGTG
GGCTGCTTCGGCTCCTCATCCCTGAGCGCTTCAACGAGACCATCGGCCTCCAGCACATTAAGGTGTACCTCTTCGACAACAGCGTCATCT
TGAGCGGTTCTGGGAACTGGACAGATTGGACAACTATAACGACACCTCCCTGGTGGAAAATCATCTCTGCCCTGCCACAGAGGGGCCCCT
CATGGCCTCCTTCAAGGCCGTGTTCGTGCCCGTGGCCTACAGCCTCATCTTCCTCCTGGGCGTGATCGGCAACGTCCTGGTGCTGGTGAT
CCTGGAGCGGCACCGGCAGACACGCAGTTCCACGGAGACCTTCCTGTTCCACCTGGCCGTGGCCGACCTCCTGCTGGTCTTCATCTTGCC
CTTTGCCGTGGCCGAGGGCTCTGTGGGCTGGGTCCTGGGGACCTTCCTCTGCAAAACTGTGATTGCCCTGCACAAAGTCAACTTCTACTG
CAGCAGCCTGCTCCTGGCCTGCATCGCCGTGGACCGCTACCTGGCCATTGTCCACGCCGTCCATGCCTACCGCCACCGCCGCCTCCTCTC
CATCCACATCACCTGTGGGACCATCTGGCTGGTGGGCTTCCTCCTTGCCTTGCCAGAGATTCTCTTCGCCAAAGTCAGCCAAGGCCATCA
CAACAACTCCCTGCCACGTTGCACCTTCTCCCAAGAGAACCAAGCAGAAACGCATGCCTGGTTCACCTCCCGATTCCTCTACCATGTGGC
GGGATTCCTGCTGCCCATGCTGGTGATGGGCTGGTGCTACGTGGGGGTAGTGCACAGGTTGCGCCAGGCCCAGCGGCGCCCTCAGCGGCA
GAAGGCAGTCAGGGTGGCCATCCTGGTGACAAGCATCTTCTTCCTCTGCTGGTCACCCTACCACATCGTCATCTTCCTGGACACCCTGGC
GAGGCTGAAGGCCGTGGACAATACCTGCAAGCTGAATGGCTCTCTCCCCGTGGCCATCACCATGTGTGAGTTCCTGGGCCTGGCCCACTG
CTGCCTCAACCCCATGCTCTACACTTTCGCCGGCGTGAAGTTCCGCAGTGACCTGTCGCGGCTCCTGACGAAGCTGGGCTGTACCGGCCC
TGCCTCCCTGTGCCAGCTCTTCCCTAGCTGGCGCAGGAGCAGTCTCTCTGAGTCAGAGAATGCCACCTCTCTCACCACGTTCTAGGTCCC
AGTGTCCCCTTTTATTGCTGCTTTTCCTTGGGGCAGGCAGTGATGCTGGATGCTCCTTCCAACAGGAGCTGGGATCCTAAGGGCTCACCG
TGGCTAAGAGTGTCCTAGGAGTATCCTCATTTGGGGTAGCTAGAGGAACCAACCCCCATTTCTAGAACATCCCTGCCAGCTCTTCTGCCG
GCCCTGGGGCTAGGCTGGAGCCCAGGGAGCGGAAAGCAGCTCAAAGGCACAGTGAAGGCTGTCCTTACCCATCTGCACCCCCCTGGGCTG
AGAGAACCTCACGCACCTCCCATCCTAATCATCCAATGCTCAAGAAACAACTTCTACTTCTGCCCTTGCCAACGGAGAGCGCCTGCCCCT
CCCAGAACACACTCCATCAGCTTAGGGGCTGCTGACCTCCACAGCTTCCCCTCTCTCCTCCTGCCCACCTGTCAAACAAAGCCAGAAGCT
GAGCACCAGGGGATGAGTGGAGGTTAAGGCTGAGGAAAGGCCAGCTGGCAGCAGAGTGTGGCCTTCGGACAACTCAGTCCCTAAAAACAC
AGACATTCTGCCAGGCCCCCAAGCCTGCAGTCATCTTGACCAAGCAGGAAGCTCAGACTGGTTGAGTTCAGGTAGCTGCCCCTGGCTCTG
ACCGAAACAGCGCTGGGTCCACCCCATGTCACCGGATCCTGGGTGGTCTGCAGGCAGGGCTGACTCTAGGTGCCCTTGGAGGCCAGCCAG
TGACCTGAGGAAGCGTGAAGGCCGAGAAGCAAGAAAGAAACCCGACAGAGGGAAGAAAAGAGCTTTCTTCCCGAACCCCAAGGAGGGAGA
TGGATCAATCAAACCCGGCGGTCCCCTCCGCCAGGCGAGATGGGGTGGGGTGGAGAACTCCTAGGGTGGCTGGGTCCAGGGGATGGGAGG
TTGTGGGCATTGATGGGGAAGGAGGCTGGCTTGTCCCCTCCTCACTCCCTTCCCATAAGCTATAGACCCGAGGAAACTCAGAGTCGGAAC
GGAGAAAGGTGGACTGGAAGGGGCCCGTGGGAGTCATCTCAACCATCCCCTCCGTGGCATCACCTTAGGCAGGGAAGTGTAAGAAACACA
CTGAGGCAGGGAAGTCCCCAGGCCCCAGGAAGCCGTGCCCTGCCCCCGTGAGGATGTCACTCAGATGGAACCGCAGGAAGCTGCTCCGTG
CTTGTTTGCTCACCTGGGGTGTGGGAGGCCCGTCCGGCAGTTCTGGGTGCTCCCTACCACCTCCCCAGCCTTTGATCAGGTGGGGAGTCA
GGGACCCCTGCCCTTGTCCCACTCAAGCCAAGCAGCCAAGCTCCTTGGGAGGCCCCACTGGGGAAATAACAGCTGTGGCTCACGTGAGAG
TGTCTTCACGGCAGGACAACGAGGAAGCCCTAAGACGTCCCTTTTTTCTCTGAGTATCTCCTCGCAAGCTGGGTAATCGATGGGGGAGTC
TGAAGCAGATGCAAAGAGGCAAGAGGCTGGATTTTGAATTTTCTTTTTAATAAAAAGGCACCTATAAAACAGGTCAATACAGTACAGGCA
GCACAGAGACCCCCGGAACAAGCCTAAAAATTGTTTCAAAATAAAAACCAAGAAGATGTCTTCACATATTGTATTTATATATTTATATTT
ATATATATATTTATATAATGGTACAAAATGGCTGGGGGTGTGGCCATGGATGGAGGGAAGAGTAGGCTGGCCTGTGGCGTGGGTGGGAGG
AGAGGGGACGGAGAGGGCACTCGGCCCGCTGCAATCTGACCCCTCTCTCCTCAGGGCAGGAAACACAGAGTCAGACAGTTTGGGGGGGTC
TTGGGCCAGGGGTGGAGGGCTCAAGGGCACAGGGCCCAGGCTGAGGCAGGGCGGGCAAAGCGCCTGGCAGGATGAAGGGCAAGTGGCCCC
CCAAACACAGAGGCCCTGGCCATGGACCCTGGGAGGTGACCGGGGTGAGTCAGGGGCCTGTTGTCAGCCCCAGAGGAAGCGCTGGACCTG
GCCGATGGTGGGCCGAGAGGACAGCACCAGGCTGGGAGAAGTGGGGCGAGTTCCCTTTGTATTACAGCTGCCAGTGCAAGACCAGGCCCT
CCAGGCCAGGAAGGCTAGGGACGGGTCCTGGTAGAAGACACCCTGTCTAGAATGGCCCTTGGTCCTGGAGGTGGGGCGCAAAAGGCCTCA
GCCAGGGAACTGCCCTGCCACCTCCCGAGGCAGGAAAGGAAGTGAGAAAAGGAGAAGTTTTTTTACTCCTGGGGCCAAAGTAGGGGGACA
AACACCCAGTCGTATATGGCTTCAGCTCTGACCAAAGGCGGATAGGGAGCTCTCCTGGGTAGGAGCAGGGAGCCAAGGGGGAGGCAGTGG
CTGTGCCTGGGTGGGCACAGACAGATCTGGTACATGGCCCTGAGCCCTGGGCAGAGGGACAACCTTGCCGGTGAGTGGGCAGGCAGAGAG
GAGGCGGCAGGATGCTGTTTCCCCGATTCCATCCTCAGGGAGTGGAGACTGGAGGGGAGGTGCACTGACTCAGATGAACTGTTCTCCCCC
TTCTTTGATAAGAAGTAGGTGGCAGCAGCCTCTGGAAAAGTCAGGGCCCTGGAGGTTACCTGGCCCAGGGCTACTACAGCCACAGGCCCC
AGTGGCACCATGCCACCCCTTCCATGGCTCCACTCAAGGGGGCCACACAGCCACCGCCTCTTCCTCCTTTCCTTCATCCCAAACTGGGAC
AAAAGACTTCAAGTTCTGGCTAAGATGTAGCAGCAGCGGATGCCCGGGCATCCAAAGTGGAAAGCCAGGGCCCCGTGTCACCGGTGTGGG
CAAACACACATGCACGTGCACACATGTTCTCCCTGAATCACTCAGCAGCAGACAGGCTGCCGCCCTGGGGGTCTCAGCCCTGCTAGGGCT
CACCAGGTGGAAGCCTAGGTGGTCTGACCTCAGTTTAGGAGTGGGTCATTTACGTCATCTTACCATTTGGGGACGAGACAGGAATGGTAT
CCCTTAGGGACCCAGAGACACTGCAAACAGTGGGTGGCCATGTAGGGCTGCATGTCCCTGGGTCCAGGGGAATGGAGGGAGCAATAACTT
GAAGAAGGGGGGAAGGGTTTCTTTTATCCTTTTTTTTTTGTGTGACTTCTATCAAAACACAGAAATACAGC

>64665_64665_1_PGS1-CXCR5_PGS1_chr17_76395618_ENST00000262764_CXCR5_chr11_118764305_ENST00000292174_length(amino acids)=352AA_BP=
MDRLDNYNDTSLVENHLCPATEGPLMASFKAVFVPVAYSLIFLLGVIGNVLVLVILERHRQTRSSTETFLFHLAVADLLLVFILPFAVAE
GSVGWVLGTFLCKTVIALHKVNFYCSSLLLACIAVDRYLAIVHAVHAYRHRRLLSIHITCGTIWLVGFLLALPEILFAKVSQGHHNNSLP
RCTFSQENQAETHAWFTSRFLYHVAGFLLPMLVMGWCYVGVVHRLRQAQRRPQRQKAVRVAILVTSIFFLCWSPYHIVIFLDTLARLKAV
DNTCKLNGSLPVAITMCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCTGPASLCQLFPSWRRSSLSESENATSLTTF

--------------------------------------------------------------
>64665_64665_2_PGS1-CXCR5_PGS1_chr17_76395618_ENST00000329897_CXCR5_chr11_118764305_ENST00000292174_length(transcript)=4793nt_BP=589nt
CTCCATGGCGGTGGCGGCGGCAGCTGCGGCGGGACCCGTGTTCTGGAGGCGACTGCTGGGCCTCCTGCCTGGCCGCCCAGGGCTGGCCGC
GCTCCTGGGACGCCTGTCCGACCGCCTCGGCAGGAACCGGGACCGCCAGCGCAGGAGCTGTTCCCCAGGTCACCTCCCCACCTTGCTGCC
TGTGTCCAGAAGGCGTGCACCGGTTCCAGTGGATCAGAAACCTGGTTCCAGAATTTGGAGTCTCCAGTTCTCACGTTAGGGTGCTTTCTT
CCCCGGCAGAGTTTTTCGAGCTCATGAAGGTGGACTGCCTGGAAAGTACTCTAGAAAAGTCACTCCAAGCAAAGTTTCCTTCAAATCTCA
AGGTCTCCATTCTCTTAGACTTCACGCGGGGCTCACGAGGCCGGAAGAACTCCCGCACAATGCTGCTCCCACTCCTGCGGAGGTTCCCAG
AGCAGGTCCGAGTCTCCCTCTTTCACACGCCGCACCTCCGTGGGCTGCTTCGGCTCCTCATCCCTGAGCGCTTCAACGAGACCATCGGCC
TCCAGCACATTAAGGTGTACCTCTTCGACAACAGCGTCATCTTGAGCGGTTCTGGGAACTGGACAGATTGGACAACTATAACGACACCTC
CCTGGTGGAAAATCATCTCTGCCCTGCCACAGAGGGGCCCCTCATGGCCTCCTTCAAGGCCGTGTTCGTGCCCGTGGCCTACAGCCTCAT
CTTCCTCCTGGGCGTGATCGGCAACGTCCTGGTGCTGGTGATCCTGGAGCGGCACCGGCAGACACGCAGTTCCACGGAGACCTTCCTGTT
CCACCTGGCCGTGGCCGACCTCCTGCTGGTCTTCATCTTGCCCTTTGCCGTGGCCGAGGGCTCTGTGGGCTGGGTCCTGGGGACCTTCCT
CTGCAAAACTGTGATTGCCCTGCACAAAGTCAACTTCTACTGCAGCAGCCTGCTCCTGGCCTGCATCGCCGTGGACCGCTACCTGGCCAT
TGTCCACGCCGTCCATGCCTACCGCCACCGCCGCCTCCTCTCCATCCACATCACCTGTGGGACCATCTGGCTGGTGGGCTTCCTCCTTGC
CTTGCCAGAGATTCTCTTCGCCAAAGTCAGCCAAGGCCATCACAACAACTCCCTGCCACGTTGCACCTTCTCCCAAGAGAACCAAGCAGA
AACGCATGCCTGGTTCACCTCCCGATTCCTCTACCATGTGGCGGGATTCCTGCTGCCCATGCTGGTGATGGGCTGGTGCTACGTGGGGGT
AGTGCACAGGTTGCGCCAGGCCCAGCGGCGCCCTCAGCGGCAGAAGGCAGTCAGGGTGGCCATCCTGGTGACAAGCATCTTCTTCCTCTG
CTGGTCACCCTACCACATCGTCATCTTCCTGGACACCCTGGCGAGGCTGAAGGCCGTGGACAATACCTGCAAGCTGAATGGCTCTCTCCC
CGTGGCCATCACCATGTGTGAGTTCCTGGGCCTGGCCCACTGCTGCCTCAACCCCATGCTCTACACTTTCGCCGGCGTGAAGTTCCGCAG
TGACCTGTCGCGGCTCCTGACGAAGCTGGGCTGTACCGGCCCTGCCTCCCTGTGCCAGCTCTTCCCTAGCTGGCGCAGGAGCAGTCTCTC
TGAGTCAGAGAATGCCACCTCTCTCACCACGTTCTAGGTCCCAGTGTCCCCTTTTATTGCTGCTTTTCCTTGGGGCAGGCAGTGATGCTG
GATGCTCCTTCCAACAGGAGCTGGGATCCTAAGGGCTCACCGTGGCTAAGAGTGTCCTAGGAGTATCCTCATTTGGGGTAGCTAGAGGAA
CCAACCCCCATTTCTAGAACATCCCTGCCAGCTCTTCTGCCGGCCCTGGGGCTAGGCTGGAGCCCAGGGAGCGGAAAGCAGCTCAAAGGC
ACAGTGAAGGCTGTCCTTACCCATCTGCACCCCCCTGGGCTGAGAGAACCTCACGCACCTCCCATCCTAATCATCCAATGCTCAAGAAAC
AACTTCTACTTCTGCCCTTGCCAACGGAGAGCGCCTGCCCCTCCCAGAACACACTCCATCAGCTTAGGGGCTGCTGACCTCCACAGCTTC
CCCTCTCTCCTCCTGCCCACCTGTCAAACAAAGCCAGAAGCTGAGCACCAGGGGATGAGTGGAGGTTAAGGCTGAGGAAAGGCCAGCTGG
CAGCAGAGTGTGGCCTTCGGACAACTCAGTCCCTAAAAACACAGACATTCTGCCAGGCCCCCAAGCCTGCAGTCATCTTGACCAAGCAGG
AAGCTCAGACTGGTTGAGTTCAGGTAGCTGCCCCTGGCTCTGACCGAAACAGCGCTGGGTCCACCCCATGTCACCGGATCCTGGGTGGTC
TGCAGGCAGGGCTGACTCTAGGTGCCCTTGGAGGCCAGCCAGTGACCTGAGGAAGCGTGAAGGCCGAGAAGCAAGAAAGAAACCCGACAG
AGGGAAGAAAAGAGCTTTCTTCCCGAACCCCAAGGAGGGAGATGGATCAATCAAACCCGGCGGTCCCCTCCGCCAGGCGAGATGGGGTGG
GGTGGAGAACTCCTAGGGTGGCTGGGTCCAGGGGATGGGAGGTTGTGGGCATTGATGGGGAAGGAGGCTGGCTTGTCCCCTCCTCACTCC
CTTCCCATAAGCTATAGACCCGAGGAAACTCAGAGTCGGAACGGAGAAAGGTGGACTGGAAGGGGCCCGTGGGAGTCATCTCAACCATCC
CCTCCGTGGCATCACCTTAGGCAGGGAAGTGTAAGAAACACACTGAGGCAGGGAAGTCCCCAGGCCCCAGGAAGCCGTGCCCTGCCCCCG
TGAGGATGTCACTCAGATGGAACCGCAGGAAGCTGCTCCGTGCTTGTTTGCTCACCTGGGGTGTGGGAGGCCCGTCCGGCAGTTCTGGGT
GCTCCCTACCACCTCCCCAGCCTTTGATCAGGTGGGGAGTCAGGGACCCCTGCCCTTGTCCCACTCAAGCCAAGCAGCCAAGCTCCTTGG
GAGGCCCCACTGGGGAAATAACAGCTGTGGCTCACGTGAGAGTGTCTTCACGGCAGGACAACGAGGAAGCCCTAAGACGTCCCTTTTTTC
TCTGAGTATCTCCTCGCAAGCTGGGTAATCGATGGGGGAGTCTGAAGCAGATGCAAAGAGGCAAGAGGCTGGATTTTGAATTTTCTTTTT
AATAAAAAGGCACCTATAAAACAGGTCAATACAGTACAGGCAGCACAGAGACCCCCGGAACAAGCCTAAAAATTGTTTCAAAATAAAAAC
CAAGAAGATGTCTTCACATATTGTATTTATATATTTATATTTATATATATATTTATATAATGGTACAAAATGGCTGGGGGTGTGGCCATG
GATGGAGGGAAGAGTAGGCTGGCCTGTGGCGTGGGTGGGAGGAGAGGGGACGGAGAGGGCACTCGGCCCGCTGCAATCTGACCCCTCTCT
CCTCAGGGCAGGAAACACAGAGTCAGACAGTTTGGGGGGGTCTTGGGCCAGGGGTGGAGGGCTCAAGGGCACAGGGCCCAGGCTGAGGCA
GGGCGGGCAAAGCGCCTGGCAGGATGAAGGGCAAGTGGCCCCCCAAACACAGAGGCCCTGGCCATGGACCCTGGGAGGTGACCGGGGTGA
GTCAGGGGCCTGTTGTCAGCCCCAGAGGAAGCGCTGGACCTGGCCGATGGTGGGCCGAGAGGACAGCACCAGGCTGGGAGAAGTGGGGCG
AGTTCCCTTTGTATTACAGCTGCCAGTGCAAGACCAGGCCCTCCAGGCCAGGAAGGCTAGGGACGGGTCCTGGTAGAAGACACCCTGTCT
AGAATGGCCCTTGGTCCTGGAGGTGGGGCGCAAAAGGCCTCAGCCAGGGAACTGCCCTGCCACCTCCCGAGGCAGGAAAGGAAGTGAGAA
AAGGAGAAGTTTTTTTACTCCTGGGGCCAAAGTAGGGGGACAAACACCCAGTCGTATATGGCTTCAGCTCTGACCAAAGGCGGATAGGGA
GCTCTCCTGGGTAGGAGCAGGGAGCCAAGGGGGAGGCAGTGGCTGTGCCTGGGTGGGCACAGACAGATCTGGTACATGGCCCTGAGCCCT
GGGCAGAGGGACAACCTTGCCGGTGAGTGGGCAGGCAGAGAGGAGGCGGCAGGATGCTGTTTCCCCGATTCCATCCTCAGGGAGTGGAGA
CTGGAGGGGAGGTGCACTGACTCAGATGAACTGTTCTCCCCCTTCTTTGATAAGAAGTAGGTGGCAGCAGCCTCTGGAAAAGTCAGGGCC
CTGGAGGTTACCTGGCCCAGGGCTACTACAGCCACAGGCCCCAGTGGCACCATGCCACCCCTTCCATGGCTCCACTCAAGGGGGCCACAC
AGCCACCGCCTCTTCCTCCTTTCCTTCATCCCAAACTGGGACAAAAGACTTCAAGTTCTGGCTAAGATGTAGCAGCAGCGGATGCCCGGG
CATCCAAAGTGGAAAGCCAGGGCCCCGTGTCACCGGTGTGGGCAAACACACATGCACGTGCACACATGTTCTCCCTGAATCACTCAGCAG
CAGACAGGCTGCCGCCCTGGGGGTCTCAGCCCTGCTAGGGCTCACCAGGTGGAAGCCTAGGTGGTCTGACCTCAGTTTAGGAGTGGGTCA
TTTACGTCATCTTACCATTTGGGGACGAGACAGGAATGGTATCCCTTAGGGACCCAGAGACACTGCAAACAGTGGGTGGCCATGTAGGGC
TGCATGTCCCTGGGTCCAGGGGAATGGAGGGAGCAATAACTTGAAGAAGGGGGGAAGGGTTTCTTTTATCCTTTTTTTTTTGTGTGACTT
CTATCAAAACACAGAAATACAGC

>64665_64665_2_PGS1-CXCR5_PGS1_chr17_76395618_ENST00000329897_CXCR5_chr11_118764305_ENST00000292174_length(amino acids)=352AA_BP=
MDRLDNYNDTSLVENHLCPATEGPLMASFKAVFVPVAYSLIFLLGVIGNVLVLVILERHRQTRSSTETFLFHLAVADLLLVFILPFAVAE
GSVGWVLGTFLCKTVIALHKVNFYCSSLLLACIAVDRYLAIVHAVHAYRHRRLLSIHITCGTIWLVGFLLALPEILFAKVSQGHHNNSLP
RCTFSQENQAETHAWFTSRFLYHVAGFLLPMLVMGWCYVGVVHRLRQAQRRPQRQKAVRVAILVTSIFFLCWSPYHIVIFLDTLARLKAV
DNTCKLNGSLPVAITMCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCTGPASLCQLFPSWRRSSLSESENATSLTTF

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Fusion Gene PPI Analysis for PGS1-CXCR5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PGS1-CXCR5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PGS1-CXCR5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0008312Primary biliary cirrhosis1CTD_human
TgeneC0023892Biliary cirrhosis1CTD_human
TgeneC0238065Secondary Biliary Cholangitis1CTD_human
TgeneC4551595Biliary Cirrhosis, Primary, 11CTD_human