Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:GTF2IRD1-ZAN (FusionGDB2 ID:HG9569TG7455)

Fusion Gene Summary for GTF2IRD1-ZAN

check button Fusion gene summary
Fusion gene informationFusion gene name: GTF2IRD1-ZAN
Fusion gene ID: hg9569tg7455
HgeneTgene
Gene symbol

GTF2IRD1

ZAN

Gene ID

9569

7455

Gene nameGTF2I repeat domain containing 1zonadhesin (gene/pseudogene)
SynonymsBEN|CREAM1|GTF3|MUSTRD1|RBAP2|WBS|WBSCR11|WBSCR12|hMusTRD1alpha1-
Cytomap('GTF2IRD1')('ZAN')

7q11.23

7q22.1

Type of geneprotein-codingprotein-coding
Descriptiongeneral transcription factor II-I repeat domain-containing protein 1USE B1-binding proteinWilliams-Beuren syndrome chromosome region 11binding factor for early enhancergeneral transcription factor 3general transcription factor IIImuscle TFII-I repeazonadhesin
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000489094, ENST00000265755, 
ENST00000424337, ENST00000455841, 
ENST00000476977, 
Fusion gene scores* DoF score11 X 6 X 9=5947 X 9 X 4=252
# samples 129
** MAII scorelog2(12/594*10)=-2.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GTF2IRD1 [Title/Abstract] AND ZAN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGTF2IRD1(73953090)-ZAN(100389588), # samples:3
Anticipated loss of major functional domain due to fusion event.GTF2IRD1-ZAN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GTF2IRD1-ZAN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GTF2IRD1-ZAN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GTF2IRD1-ZAN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GTF2IRD1-ZAN seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
GTF2IRD1-ZAN seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GTF2IRD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ZAN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-49-AAR0-01AGTF2IRD1chr7

73953090

-ZANchr7

100389588

+
ChimerDB4LUADTCGA-49-AAR0-01AGTF2IRD1chr7

73953090

+ZANchr7

100389588

+
ChimerDB4LUADTCGA-49-AAR0GTF2IRD1chr7

73953090

+ZANchr7

100389588

+


Top

Fusion Gene ORF analysis for GTF2IRD1-ZAN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000489094ENST00000348028GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
3UTR-3CDSENST00000489094ENST00000349350GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
3UTR-3CDSENST00000489094ENST00000421100GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
3UTR-3CDSENST00000489094ENST00000427578GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
3UTR-3CDSENST00000489094ENST00000443370GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
3UTR-3CDSENST00000489094ENST00000449052GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
3UTR-3CDSENST00000489094ENST00000538115GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
3UTR-3CDSENST00000489094ENST00000542585GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
3UTR-3CDSENST00000489094ENST00000546213GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
3UTR-3CDSENST00000489094ENST00000546292GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000265755ENST00000348028GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000265755ENST00000349350GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000265755ENST00000421100GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000265755ENST00000427578GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000265755ENST00000443370GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000265755ENST00000449052GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000265755ENST00000538115GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000265755ENST00000542585GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000265755ENST00000546292GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000424337ENST00000348028GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000424337ENST00000349350GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000424337ENST00000421100GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000424337ENST00000427578GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000424337ENST00000443370GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000424337ENST00000449052GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000424337ENST00000538115GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000424337ENST00000542585GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000424337ENST00000546292GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000455841ENST00000348028GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000455841ENST00000349350GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000455841ENST00000421100GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000455841ENST00000427578GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000455841ENST00000443370GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000455841ENST00000449052GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000455841ENST00000538115GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000455841ENST00000542585GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000455841ENST00000546292GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000476977ENST00000348028GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000476977ENST00000349350GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000476977ENST00000421100GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000476977ENST00000427578GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000476977ENST00000443370GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000476977ENST00000449052GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000476977ENST00000538115GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000476977ENST00000542585GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
Frame-shiftENST00000476977ENST00000546292GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
In-frameENST00000265755ENST00000546213GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
In-frameENST00000424337ENST00000546213GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
In-frameENST00000455841ENST00000546213GTF2IRD1chr7

73953090

+ZANchr7

100389588

+
In-frameENST00000476977ENST00000546213GTF2IRD1chr7

73953090

+ZANchr7

100389588

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265755GTF2IRD1chr773953090+ENST00000546213ZANchr7100389588+276419213302699789
ENST00000455841GTF2IRD1chr773953090+ENST00000546213ZANchr7100389588+268018371502615821
ENST00000424337GTF2IRD1chr773953090+ENST00000546213ZANchr7100389588+24451602112380789
ENST00000476977GTF2IRD1chr773953090+ENST00000546213ZANchr7100389588+4062321916913997768

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265755ENST00000546213GTF2IRD1chr773953090+ZANchr7100389588+0.0261593370.97384065
ENST00000455841ENST00000546213GTF2IRD1chr773953090+ZANchr7100389588+0.0203566720.9796433
ENST00000424337ENST00000546213GTF2IRD1chr773953090+ZANchr7100389588+0.0271242450.97287583
ENST00000476977ENST00000546213GTF2IRD1chr773953090+ZANchr7100389588+0.027718260.97228175

Top

Fusion Genomic Features for GTF2IRD1-ZAN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GTF2IRD1chr773953090+ZANchr7100389587+5.09E-070.9999995
GTF2IRD1chr773953090+ZANchr7100389587+5.09E-070.9999995
GTF2IRD1chr773953090+ZANchr7100389587+5.09E-070.9999995
GTF2IRD1chr773953090+ZANchr7100389587+5.09E-070.9999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for GTF2IRD1-ZAN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:73953090/chr7:100389588)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGTF2IRD1chr7:73953090chr7:100389588ENST00000265755+1327119_213509960.0RepeatNote=GTF2I-like 1
HgeneGTF2IRD1chr7:73953090chr7:100389588ENST00000265755+1327342_436509960.0RepeatNote=GTF2I-like 2
HgeneGTF2IRD1chr7:73953090chr7:100389588ENST00000424337+1327119_213509945.0RepeatNote=GTF2I-like 1
HgeneGTF2IRD1chr7:73953090chr7:100389588ENST00000424337+1327342_436509945.0RepeatNote=GTF2I-like 2
HgeneGTF2IRD1chr7:73953090chr7:100389588ENST00000455841+1327119_213541977.0RepeatNote=GTF2I-like 1
HgeneGTF2IRD1chr7:73953090chr7:100389588ENST00000455841+1327342_436541977.0RepeatNote=GTF2I-like 2
TgeneZANchr7:73953090chr7:100389588ENST0000034802839462652_279725092721.6666666666665DomainNote=VWFC 5
TgeneZANchr7:73953090chr7:100389588ENST0000034802839462708_274425092721.6666666666665DomainEGF-like
TgeneZANchr7:73953090chr7:100389588ENST0000034935039482652_279725092812.6666666666665DomainNote=VWFC 5
TgeneZANchr7:73953090chr7:100389588ENST0000034935039482708_274425092812.6666666666665DomainEGF-like
TgeneZANchr7:73953090chr7:100389588ENST0000042110039472652_279725092588.6666666666665DomainNote=VWFC 5
TgeneZANchr7:73953090chr7:100389588ENST0000042110039472708_274425092588.6666666666665DomainEGF-like
TgeneZANchr7:73953090chr7:100389588ENST0000042757839472652_279725092711.6666666666665DomainNote=VWFC 5
TgeneZANchr7:73953090chr7:100389588ENST0000042757839472708_274425092711.6666666666665DomainEGF-like
TgeneZANchr7:73953090chr7:100389588ENST0000044337039472652_279725092611.6666666666665DomainNote=VWFC 5
TgeneZANchr7:73953090chr7:100389588ENST0000044337039472708_274425092611.6666666666665DomainEGF-like
TgeneZANchr7:73953090chr7:100389588ENST0000044905239482652_279725092676.6666666666665DomainNote=VWFC 5
TgeneZANchr7:73953090chr7:100389588ENST0000044905239482708_274425092676.6666666666665DomainEGF-like
TgeneZANchr7:73953090chr7:100389588ENST0000034802839462779_281225092721.6666666666665Topological domainCytoplasmic
TgeneZANchr7:73953090chr7:100389588ENST0000034935039482779_281225092812.6666666666665Topological domainCytoplasmic
TgeneZANchr7:73953090chr7:100389588ENST0000042110039472779_281225092588.6666666666665Topological domainCytoplasmic
TgeneZANchr7:73953090chr7:100389588ENST0000042757839472779_281225092711.6666666666665Topological domainCytoplasmic
TgeneZANchr7:73953090chr7:100389588ENST0000044337039472779_281225092611.6666666666665Topological domainCytoplasmic
TgeneZANchr7:73953090chr7:100389588ENST0000044905239482779_281225092676.6666666666665Topological domainCytoplasmic
TgeneZANchr7:73953090chr7:100389588ENST0000034802839462758_277825092721.6666666666665TransmembraneHelical
TgeneZANchr7:73953090chr7:100389588ENST0000034935039482758_277825092812.6666666666665TransmembraneHelical
TgeneZANchr7:73953090chr7:100389588ENST0000042110039472758_277825092588.6666666666665TransmembraneHelical
TgeneZANchr7:73953090chr7:100389588ENST0000042757839472758_277825092711.6666666666665TransmembraneHelical
TgeneZANchr7:73953090chr7:100389588ENST0000044337039472758_277825092611.6666666666665TransmembraneHelical
TgeneZANchr7:73953090chr7:100389588ENST0000044905239482758_277825092676.6666666666665TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGTF2IRD1chr7:73953090chr7:100389588ENST00000265755+1327906_930509960.0Compositional biasNote=Ser-rich
HgeneGTF2IRD1chr7:73953090chr7:100389588ENST00000424337+1327906_930509945.0Compositional biasNote=Ser-rich
HgeneGTF2IRD1chr7:73953090chr7:100389588ENST00000455841+1327906_930541977.0Compositional biasNote=Ser-rich
HgeneGTF2IRD1chr7:73953090chr7:100389588ENST00000265755+1327898_905509960.0MotifNuclear localization signal
HgeneGTF2IRD1chr7:73953090chr7:100389588ENST00000424337+1327898_905509945.0MotifNuclear localization signal
HgeneGTF2IRD1chr7:73953090chr7:100389588ENST00000455841+1327898_905541977.0MotifNuclear localization signal
HgeneGTF2IRD1chr7:73953090chr7:100389588ENST00000265755+1327556_650509960.0RepeatNote=GTF2I-like 3
HgeneGTF2IRD1chr7:73953090chr7:100389588ENST00000265755+1327696_790509960.0RepeatNote=GTF2I-like 4
HgeneGTF2IRD1chr7:73953090chr7:100389588ENST00000265755+1327793_887509960.0RepeatNote=GTF2I-like 5
HgeneGTF2IRD1chr7:73953090chr7:100389588ENST00000424337+1327556_650509945.0RepeatNote=GTF2I-like 3
HgeneGTF2IRD1chr7:73953090chr7:100389588ENST00000424337+1327696_790509945.0RepeatNote=GTF2I-like 4
HgeneGTF2IRD1chr7:73953090chr7:100389588ENST00000424337+1327793_887509945.0RepeatNote=GTF2I-like 5
HgeneGTF2IRD1chr7:73953090chr7:100389588ENST00000455841+1327556_650541977.0RepeatNote=GTF2I-like 3
HgeneGTF2IRD1chr7:73953090chr7:100389588ENST00000455841+1327696_790541977.0RepeatNote=GTF2I-like 4
HgeneGTF2IRD1chr7:73953090chr7:100389588ENST00000455841+1327793_887541977.0RepeatNote=GTF2I-like 5
TgeneZANchr7:73953090chr7:100389588ENST0000034802839461044_109325092721.6666666666665DomainNote=TIL 1
TgeneZANchr7:73953090chr7:100389588ENST0000034802839461103_114825092721.6666666666665DomainNote=VWFC 1
TgeneZANchr7:73953090chr7:100389588ENST0000034802839461155_137125092721.6666666666665DomainVWFD 1
TgeneZANchr7:73953090chr7:100389588ENST0000034802839461426_147925092721.6666666666665DomainNote=TIL 2
TgeneZANchr7:73953090chr7:100389588ENST0000034802839461480_153525092721.6666666666665DomainNote=VWFC 2
TgeneZANchr7:73953090chr7:100389588ENST0000034802839461541_175825092721.6666666666665DomainVWFD 2
TgeneZANchr7:73953090chr7:100389588ENST0000034802839461812_186725092721.6666666666665DomainNote=TIL 3
TgeneZANchr7:73953090chr7:100389588ENST0000034802839461868_192425092721.6666666666665DomainNote=VWFC 3
TgeneZANchr7:73953090chr7:100389588ENST0000034802839461930_214425092721.6666666666665DomainVWFD 3
TgeneZANchr7:73953090chr7:100389588ENST000003480283946209_36825092721.6666666666665DomainMAM 2
TgeneZANchr7:73953090chr7:100389588ENST0000034802839462211_226725092721.6666666666665DomainNote=TIL 4
TgeneZANchr7:73953090chr7:100389588ENST0000034802839462268_232925092721.6666666666665DomainNote=VWFC 4
TgeneZANchr7:73953090chr7:100389588ENST0000034802839462330_253725092721.6666666666665DomainVWFD 4
TgeneZANchr7:73953090chr7:100389588ENST000003480283946371_53625092721.6666666666665DomainMAM 3
TgeneZANchr7:73953090chr7:100389588ENST00000348028394639_20425092721.6666666666665DomainMAM 1
TgeneZANchr7:73953090chr7:100389588ENST0000034935039481044_109325092812.6666666666665DomainNote=TIL 1
TgeneZANchr7:73953090chr7:100389588ENST0000034935039481103_114825092812.6666666666665DomainNote=VWFC 1
TgeneZANchr7:73953090chr7:100389588ENST0000034935039481155_137125092812.6666666666665DomainVWFD 1
TgeneZANchr7:73953090chr7:100389588ENST0000034935039481426_147925092812.6666666666665DomainNote=TIL 2
TgeneZANchr7:73953090chr7:100389588ENST0000034935039481480_153525092812.6666666666665DomainNote=VWFC 2
TgeneZANchr7:73953090chr7:100389588ENST0000034935039481541_175825092812.6666666666665DomainVWFD 2
TgeneZANchr7:73953090chr7:100389588ENST0000034935039481812_186725092812.6666666666665DomainNote=TIL 3
TgeneZANchr7:73953090chr7:100389588ENST0000034935039481868_192425092812.6666666666665DomainNote=VWFC 3
TgeneZANchr7:73953090chr7:100389588ENST0000034935039481930_214425092812.6666666666665DomainVWFD 3
TgeneZANchr7:73953090chr7:100389588ENST000003493503948209_36825092812.6666666666665DomainMAM 2
TgeneZANchr7:73953090chr7:100389588ENST0000034935039482211_226725092812.6666666666665DomainNote=TIL 4
TgeneZANchr7:73953090chr7:100389588ENST0000034935039482268_232925092812.6666666666665DomainNote=VWFC 4
TgeneZANchr7:73953090chr7:100389588ENST0000034935039482330_253725092812.6666666666665DomainVWFD 4
TgeneZANchr7:73953090chr7:100389588ENST000003493503948371_53625092812.6666666666665DomainMAM 3
TgeneZANchr7:73953090chr7:100389588ENST00000349350394839_20425092812.6666666666665DomainMAM 1
TgeneZANchr7:73953090chr7:100389588ENST0000042110039471044_109325092588.6666666666665DomainNote=TIL 1
TgeneZANchr7:73953090chr7:100389588ENST0000042110039471103_114825092588.6666666666665DomainNote=VWFC 1
TgeneZANchr7:73953090chr7:100389588ENST0000042110039471155_137125092588.6666666666665DomainVWFD 1
TgeneZANchr7:73953090chr7:100389588ENST0000042110039471426_147925092588.6666666666665DomainNote=TIL 2
TgeneZANchr7:73953090chr7:100389588ENST0000042110039471480_153525092588.6666666666665DomainNote=VWFC 2
TgeneZANchr7:73953090chr7:100389588ENST0000042110039471541_175825092588.6666666666665DomainVWFD 2
TgeneZANchr7:73953090chr7:100389588ENST0000042110039471812_186725092588.6666666666665DomainNote=TIL 3
TgeneZANchr7:73953090chr7:100389588ENST0000042110039471868_192425092588.6666666666665DomainNote=VWFC 3
TgeneZANchr7:73953090chr7:100389588ENST0000042110039471930_214425092588.6666666666665DomainVWFD 3
TgeneZANchr7:73953090chr7:100389588ENST000004211003947209_36825092588.6666666666665DomainMAM 2
TgeneZANchr7:73953090chr7:100389588ENST0000042110039472211_226725092588.6666666666665DomainNote=TIL 4
TgeneZANchr7:73953090chr7:100389588ENST0000042110039472268_232925092588.6666666666665DomainNote=VWFC 4
TgeneZANchr7:73953090chr7:100389588ENST0000042110039472330_253725092588.6666666666665DomainVWFD 4
TgeneZANchr7:73953090chr7:100389588ENST000004211003947371_53625092588.6666666666665DomainMAM 3
TgeneZANchr7:73953090chr7:100389588ENST00000421100394739_20425092588.6666666666665DomainMAM 1
TgeneZANchr7:73953090chr7:100389588ENST0000042757839471044_109325092711.6666666666665DomainNote=TIL 1
TgeneZANchr7:73953090chr7:100389588ENST0000042757839471103_114825092711.6666666666665DomainNote=VWFC 1
TgeneZANchr7:73953090chr7:100389588ENST0000042757839471155_137125092711.6666666666665DomainVWFD 1
TgeneZANchr7:73953090chr7:100389588ENST0000042757839471426_147925092711.6666666666665DomainNote=TIL 2
TgeneZANchr7:73953090chr7:100389588ENST0000042757839471480_153525092711.6666666666665DomainNote=VWFC 2
TgeneZANchr7:73953090chr7:100389588ENST0000042757839471541_175825092711.6666666666665DomainVWFD 2
TgeneZANchr7:73953090chr7:100389588ENST0000042757839471812_186725092711.6666666666665DomainNote=TIL 3
TgeneZANchr7:73953090chr7:100389588ENST0000042757839471868_192425092711.6666666666665DomainNote=VWFC 3
TgeneZANchr7:73953090chr7:100389588ENST0000042757839471930_214425092711.6666666666665DomainVWFD 3
TgeneZANchr7:73953090chr7:100389588ENST000004275783947209_36825092711.6666666666665DomainMAM 2
TgeneZANchr7:73953090chr7:100389588ENST0000042757839472211_226725092711.6666666666665DomainNote=TIL 4
TgeneZANchr7:73953090chr7:100389588ENST0000042757839472268_232925092711.6666666666665DomainNote=VWFC 4
TgeneZANchr7:73953090chr7:100389588ENST0000042757839472330_253725092711.6666666666665DomainVWFD 4
TgeneZANchr7:73953090chr7:100389588ENST000004275783947371_53625092711.6666666666665DomainMAM 3
TgeneZANchr7:73953090chr7:100389588ENST00000427578394739_20425092711.6666666666665DomainMAM 1
TgeneZANchr7:73953090chr7:100389588ENST0000044337039471044_109325092611.6666666666665DomainNote=TIL 1
TgeneZANchr7:73953090chr7:100389588ENST0000044337039471103_114825092611.6666666666665DomainNote=VWFC 1
TgeneZANchr7:73953090chr7:100389588ENST0000044337039471155_137125092611.6666666666665DomainVWFD 1
TgeneZANchr7:73953090chr7:100389588ENST0000044337039471426_147925092611.6666666666665DomainNote=TIL 2
TgeneZANchr7:73953090chr7:100389588ENST0000044337039471480_153525092611.6666666666665DomainNote=VWFC 2
TgeneZANchr7:73953090chr7:100389588ENST0000044337039471541_175825092611.6666666666665DomainVWFD 2
TgeneZANchr7:73953090chr7:100389588ENST0000044337039471812_186725092611.6666666666665DomainNote=TIL 3
TgeneZANchr7:73953090chr7:100389588ENST0000044337039471868_192425092611.6666666666665DomainNote=VWFC 3
TgeneZANchr7:73953090chr7:100389588ENST0000044337039471930_214425092611.6666666666665DomainVWFD 3
TgeneZANchr7:73953090chr7:100389588ENST000004433703947209_36825092611.6666666666665DomainMAM 2
TgeneZANchr7:73953090chr7:100389588ENST0000044337039472211_226725092611.6666666666665DomainNote=TIL 4
TgeneZANchr7:73953090chr7:100389588ENST0000044337039472268_232925092611.6666666666665DomainNote=VWFC 4
TgeneZANchr7:73953090chr7:100389588ENST0000044337039472330_253725092611.6666666666665DomainVWFD 4
TgeneZANchr7:73953090chr7:100389588ENST000004433703947371_53625092611.6666666666665DomainMAM 3
TgeneZANchr7:73953090chr7:100389588ENST00000443370394739_20425092611.6666666666665DomainMAM 1
TgeneZANchr7:73953090chr7:100389588ENST0000044905239481044_109325092676.6666666666665DomainNote=TIL 1
TgeneZANchr7:73953090chr7:100389588ENST0000044905239481103_114825092676.6666666666665DomainNote=VWFC 1
TgeneZANchr7:73953090chr7:100389588ENST0000044905239481155_137125092676.6666666666665DomainVWFD 1
TgeneZANchr7:73953090chr7:100389588ENST0000044905239481426_147925092676.6666666666665DomainNote=TIL 2
TgeneZANchr7:73953090chr7:100389588ENST0000044905239481480_153525092676.6666666666665DomainNote=VWFC 2
TgeneZANchr7:73953090chr7:100389588ENST0000044905239481541_175825092676.6666666666665DomainVWFD 2
TgeneZANchr7:73953090chr7:100389588ENST0000044905239481812_186725092676.6666666666665DomainNote=TIL 3
TgeneZANchr7:73953090chr7:100389588ENST0000044905239481868_192425092676.6666666666665DomainNote=VWFC 3
TgeneZANchr7:73953090chr7:100389588ENST0000044905239481930_214425092676.6666666666665DomainVWFD 3
TgeneZANchr7:73953090chr7:100389588ENST000004490523948209_36825092676.6666666666665DomainMAM 2
TgeneZANchr7:73953090chr7:100389588ENST0000044905239482211_226725092676.6666666666665DomainNote=TIL 4
TgeneZANchr7:73953090chr7:100389588ENST0000044905239482268_232925092676.6666666666665DomainNote=VWFC 4
TgeneZANchr7:73953090chr7:100389588ENST0000044905239482330_253725092676.6666666666665DomainVWFD 4
TgeneZANchr7:73953090chr7:100389588ENST000004490523948371_53625092676.6666666666665DomainMAM 3
TgeneZANchr7:73953090chr7:100389588ENST00000449052394839_20425092676.6666666666665DomainMAM 1
TgeneZANchr7:73953090chr7:100389588ENST000003480283946573_104125092721.6666666666665RegionNote=66 X heptapeptide repeats (approximate) (mucin-like domain)
TgeneZANchr7:73953090chr7:100389588ENST000003493503948573_104125092812.6666666666665RegionNote=66 X heptapeptide repeats (approximate) (mucin-like domain)
TgeneZANchr7:73953090chr7:100389588ENST000004211003947573_104125092588.6666666666665RegionNote=66 X heptapeptide repeats (approximate) (mucin-like domain)
TgeneZANchr7:73953090chr7:100389588ENST000004275783947573_104125092711.6666666666665RegionNote=66 X heptapeptide repeats (approximate) (mucin-like domain)
TgeneZANchr7:73953090chr7:100389588ENST000004433703947573_104125092611.6666666666665RegionNote=66 X heptapeptide repeats (approximate) (mucin-like domain)
TgeneZANchr7:73953090chr7:100389588ENST000004490523948573_104125092676.6666666666665RegionNote=66 X heptapeptide repeats (approximate) (mucin-like domain)
TgeneZANchr7:73953090chr7:100389588ENST00000348028394618_275725092721.6666666666665Topological domainExtracellular
TgeneZANchr7:73953090chr7:100389588ENST00000349350394818_275725092812.6666666666665Topological domainExtracellular
TgeneZANchr7:73953090chr7:100389588ENST00000421100394718_275725092588.6666666666665Topological domainExtracellular
TgeneZANchr7:73953090chr7:100389588ENST00000427578394718_275725092711.6666666666665Topological domainExtracellular
TgeneZANchr7:73953090chr7:100389588ENST00000443370394718_275725092611.6666666666665Topological domainExtracellular
TgeneZANchr7:73953090chr7:100389588ENST00000449052394818_275725092676.6666666666665Topological domainExtracellular


Top

Fusion Gene Sequence for GTF2IRD1-ZAN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>35258_35258_1_GTF2IRD1-ZAN_GTF2IRD1_chr7_73953090_ENST00000265755_ZAN_chr7_100389588_ENST00000546213_length(transcript)=2764nt_BP=1921nt
TAAATGGCAGCCAATGGAGGGTGGTGTTGCGCGGGGCTGGGATTAGGGCCGGGGCGAATGGCTGGCAATCTTACTGGGATTACAGAACAA
AGAGCCTCCCCGCGCTCCCGCTCTCCGCTCCTCTCCCCGCGCCGCCCCGCCCTCCGCCGCAGCCCGCGCCGGGGGTGGGGGCCGCCGAGC
GCCAGCCCCCCGGCCGGCCGATTCCCCCCCCGCGCCCCCTCCCCGCGCCTCCCTCCCCGCCCTCGCCGCGCCGCCGTCCTCGCCTCCCTC
TGCCTCTCCTTCCCCCATTCTCCCGGATTAATTAAGGAGGCAGCGGCAGGAGGCTGAGTCCTGGCCGCGGGCCGGGGCCGGGGCGCCGCT
GGCAGGAGCGCTTGGGGATCCTCCAAGGCGACCATGGCCTTGCTGGGTAAGCGCTGTGACGTCCCCACCAACGGCTGCGGACCCGACCGC
TGGAACTCCGCGTTCACCCGCAAAGACGAGATCATCACCAGCCTCGTGTCTGCCTTAGACTCCATGTGCTCAGCGCTGTCCAAACTGAAC
GCCGAGGTGGCCTGTGTCGCCGTGCACGATGAGAGCGCCTTTGTGGTGGGCACAGAGAAGGGGAGAATGTTCCTGAATGCCCGGAAGGAG
CTACAGTCAGACTTCCTCAGGTTCTGCCGAGGGCCCCCGTGGAAGGATCCGGAGGCAGAGCACCCCAAGAAGGTGCAGCGGGGCGAGGGT
GGAGGCCGTAGCCTCCCTCGGTCCTCCCTGGAACATGGCTCAGATGTGTACCTTCTGCGGAAGATGGTAGAGGAGGTGTTTGATGTTCTT
TATAGCGAGGCCCTGGGAAGGGCCAGTGTGGTGCCACTGCCCTATGAGAGGCTGCTCAGGGAGCCAGGGCTGCTGGCCGTGCAGGGGCTG
CCCGAAGGCCTGGCCTTCCGAAGGCCAGCCGAGTATGACCCCAAGGCCCTCATGGCCATCCTGGAACACAGCCACCGCATCCGCTTCAAG
CTCAAGAGGCCACTTGAGGATGGCGGGCGGGACTCGAAGGCCCTGGTGGAGCTGAACGGTGTCTCCCTGATTCCCAAGGGGTCACGGGAC
TGTGGCCTGCATGGCCAGGCCCCCAAGGTGCCACCCCAGGACCTGCCCCCAACCGCCACCTCCTCCTCCATGGCCAGCTTCCTGTACAGC
ACGGCGCTCCCCAACCACGCCATCCGAGAGCTCAAGCAGGAAGCACCTTCCTGCCCCCTTGCCCCCAGCGACCTGGGCCTGAGTCGGCCC
ATGCCAGAGCCCAAGGCCACCGGTGCCCAAGACTTCTCCGACTGTTGTGGACAGAAGCCCACTGGGCCTGGTGGGCCTCTCATCCAGAAC
GTCCATGCCTCCAAGCGCATTCTCTTCTCCATCGTCCATGACAAGTCAGAGAAGTGGGACGCCTTCATAAAGGAAACCGAGGACATCAAC
ACGCTCCGGGAGTGTGTGCAGATCCTGTTTAACAGCAGATATGCGGAAGCCCTGGGCCTGGACCACATGGTCCCCGTGCCCTACCGGAAG
ATTGCCTGTGACCCGGAGGCTGTGGAGATCGTGGGCATCCCGGACAAGATCCCCTTCAAGCGCCCCTGCACTTATGGAGTCCCCAAGCTG
AAGCGGATCCTGGAGGAGCGCCATAGTATCCACTTCATCATTAAGAGGATGTTTGATGAGCGAATTTTCACAGGGAACAAGTTTACCAAA
GACACCACGAAGCTGGAGCCAGCCAGCCCGCCAGAGGACACCTCTGCAGAGGTCTCTAGGGCCACCGTCCTTGACCTTGCTGGGAATGCT
CGGTCAGACAAGGGCAGCATGTCTGAAGACTGTGGGCCAGGAACCTCCGGGGAGCTGGGCGGGCTGAGGCCGATCAAAATTGAGCCAGAG
GATCTGGACATCATTCAGGTCACCGTCCCAGGGCTATACCAGCGGAGGAGGAGGGACAAGGGGCGGAGCTGGGCCTCCGCACGGGCCTCC
AAGTGTCCGAATGTAGCCCGGAGCAGCTGGCGAGCAACAGCACCCAGGCCTGTAGGGTGCTGGCAGACCCCCAGGGCCCCTTTGCTGCCT
GTCACCAGACGGTGGCCCCAGAGCCCTTCCAAGAGCACTGCGTGCTGGATCTGTGCTCTGCTCAGGACCCAAGAGAGCAAGAGGAGCTGC
GTTGCCAGGTCCTCAGTGGGTACGCCATCCTCTGCCAGGAGGCGGGCGCTGCCCTGGCTGGCTGGCGGGACCGCACCCTCTGCGCTGGGC
AGCAGCTTTCTGACTGAGGACTGCTCTCAGCGGTGCACCTGTGCCAGCTCACGGATCCTGCTGTGTGAGCCCTTCAGCTGCAGAGCGGGG
GAGGTCTGCACCCTGGGGAACCACACCCAAGGCTGCTTTCCAGAAAGCCCGTGTCTGCAGAACCCCTGTCAGAATGACGGGCAGTGTCGG
GAGCAGGGAGCCACCTTCACCTGCGAGTGTGAAGTTGGTTACGGGGGAGGCCTGTGTATGGAGCCTCGAGATGCGCCACCTCCCAGAAAG
CCAGAAGCATCTAACCTGGTGGGCGTCCTACTGGGACTGCTGGTGCCTGTGGTGGTCGTACTACTGGCCGTGACCAGAGAGTGCATTTAC
AGAACGAGGAGGAAGAGAGAGAAAACGCAGGAGGGAGACAGACTGGCCAGGCTGGTGGACACAGATACTGTTCTGGACTGTGCCTGTTAA

>35258_35258_1_GTF2IRD1-ZAN_GTF2IRD1_chr7_73953090_ENST00000265755_ZAN_chr7_100389588_ENST00000546213_length(amino acids)=789AA_BP=530
MAAGRGRGAAGRSAWGSSKATMALLGKRCDVPTNGCGPDRWNSAFTRKDEIITSLVSALDSMCSALSKLNAEVACVAVHDESAFVVGTEK
GRMFLNARKELQSDFLRFCRGPPWKDPEAEHPKKVQRGEGGGRSLPRSSLEHGSDVYLLRKMVEEVFDVLYSEALGRASVVPLPYERLLR
EPGLLAVQGLPEGLAFRRPAEYDPKALMAILEHSHRIRFKLKRPLEDGGRDSKALVELNGVSLIPKGSRDCGLHGQAPKVPPQDLPPTAT
SSSMASFLYSTALPNHAIRELKQEAPSCPLAPSDLGLSRPMPEPKATGAQDFSDCCGQKPTGPGGPLIQNVHASKRILFSIVHDKSEKWD
AFIKETEDINTLRECVQILFNSRYAEALGLDHMVPVPYRKIACDPEAVEIVGIPDKIPFKRPCTYGVPKLKRILEERHSIHFIIKRMFDE
RIFTGNKFTKDTTKLEPASPPEDTSAEVSRATVLDLAGNARSDKGSMSEDCGPGTSGELGGLRPIKIEPEDLDIIQVTVPGLYQRRRRDK
GRSWASARASKCPNVARSSWRATAPRPVGCWQTPRAPLLPVTRRWPQSPSKSTACWICALLRTQESKRSCVARSSVGTPSSARRRALPWL
AGGTAPSALGSSFLTEDCSQRCTCASSRILLCEPFSCRAGEVCTLGNHTQGCFPESPCLQNPCQNDGQCREQGATFTCECEVGYGGGLCM

--------------------------------------------------------------
>35258_35258_2_GTF2IRD1-ZAN_GTF2IRD1_chr7_73953090_ENST00000424337_ZAN_chr7_100389588_ENST00000546213_length(transcript)=2445nt_BP=1602nt
GAGGCTGAGTCCTGGCCGCGGGCCGGGGCCGGGGCGCCGCTGGCAGGAGCGCTTGGGGATCCTCCAAGGCGACCATGGCCTTGCTGGGTA
AGCGCTGTGACGTCCCCACCAACGGCTGCGGACCCGACCGCTGGAACTCCGCGTTCACCCGCAAAGACGAGATCATCACCAGCCTCGTGT
CTGCCTTAGACTCCATGTGCTCAGCGCTGTCCAAACTGAACGCCGAGGTGGCCTGTGTCGCCGTGCACGATGAGAGCGCCTTTGTGGTGG
GCACAGAGAAGGGGAGAATGTTCCTGAATGCCCGGAAGGAGCTACAGTCAGACTTCCTCAGGTTCTGCCGAGGGCCCCCGTGGAAGGATC
CGGAGGCAGAGCACCCCAAGAAGGTGCAGCGGGGCGAGGGTGGAGGCCGTAGCCTCCCTCGGTCCTCCCTGGAACATGGCTCAGATGTGT
ACCTTCTGCGGAAGATGGTAGAGGAGGTGTTTGATGTTCTTTATAGCGAGGCCCTGGGAAGGGCCAGTGTGGTGCCACTGCCCTATGAGA
GGCTGCTCAGGGAGCCAGGGCTGCTGGCCGTGCAGGGGCTGCCCGAAGGCCTGGCCTTCCGAAGGCCAGCCGAGTATGACCCCAAGGCCC
TCATGGCCATCCTGGAACACAGCCACCGCATCCGCTTCAAGCTCAAGAGGCCACTTGAGGATGGCGGGCGGGACTCGAAGGCCCTGGTGG
AGCTGAACGGTGTCTCCCTGATTCCCAAGGGGTCACGGGACTGTGGCCTGCATGGCCAGGCCCCCAAGGTGCCACCCCAGGACCTGCCCC
CAACCGCCACCTCCTCCTCCATGGCCAGCTTCCTGTACAGCACGGCGCTCCCCAACCACGCCATCCGAGAGCTCAAGCAGGAAGCACCTT
CCTGCCCCCTTGCCCCCAGCGACCTGGGCCTGAGTCGGCCCATGCCAGAGCCCAAGGCCACCGGTGCCCAAGACTTCTCCGACTGTTGTG
GACAGAAGCCCACTGGGCCTGGTGGGCCTCTCATCCAGAACGTCCATGCCTCCAAGCGCATTCTCTTCTCCATCGTCCATGACAAGTCAG
AGAAGTGGGACGCCTTCATAAAGGAAACCGAGGACATCAACACGCTCCGGGAGTGTGTGCAGATCCTGTTTAACAGCAGATATGCGGAAG
CCCTGGGCCTGGACCACATGGTCCCCGTGCCCTACCGGAAGATTGCCTGTGACCCGGAGGCTGTGGAGATCGTGGGCATCCCGGACAAGA
TCCCCTTCAAGCGCCCCTGCACTTATGGAGTCCCCAAGCTGAAGCGGATCCTGGAGGAGCGCCATAGTATCCACTTCATCATTAAGAGGA
TGTTTGATGAGCGAATTTTCACAGGGAACAAGTTTACCAAAGACACCACGAAGCTGGAGCCAGCCAGCCCGCCAGAGGACACCTCTGCAG
AGGTCTCTAGGGCCACCGTCCTTGACCTTGCTGGGAATGCTCGGTCAGACAAGGGCAGCATGTCTGAAGACTGTGGGCCAGGAACCTCCG
GGGAGCTGGGCGGGCTGAGGCCGATCAAAATTGAGCCAGAGGATCTGGACATCATTCAGGTCACCGTCCCAGGGCTATACCAGCGGAGGA
GGAGGGACAAGGGGCGGAGCTGGGCCTCCGCACGGGCCTCCAAGTGTCCGAATGTAGCCCGGAGCAGCTGGCGAGCAACAGCACCCAGGC
CTGTAGGGTGCTGGCAGACCCCCAGGGCCCCTTTGCTGCCTGTCACCAGACGGTGGCCCCAGAGCCCTTCCAAGAGCACTGCGTGCTGGA
TCTGTGCTCTGCTCAGGACCCAAGAGAGCAAGAGGAGCTGCGTTGCCAGGTCCTCAGTGGGTACGCCATCCTCTGCCAGGAGGCGGGCGC
TGCCCTGGCTGGCTGGCGGGACCGCACCCTCTGCGCTGGGCAGCAGCTTTCTGACTGAGGACTGCTCTCAGCGGTGCACCTGTGCCAGCT
CACGGATCCTGCTGTGTGAGCCCTTCAGCTGCAGAGCGGGGGAGGTCTGCACCCTGGGGAACCACACCCAAGGCTGCTTTCCAGAAAGCC
CGTGTCTGCAGAACCCCTGTCAGAATGACGGGCAGTGTCGGGAGCAGGGAGCCACCTTCACCTGCGAGTGTGAAGTTGGTTACGGGGGAG
GCCTGTGTATGGAGCCTCGAGATGCGCCACCTCCCAGAAAGCCAGAAGCATCTAACCTGGTGGGCGTCCTACTGGGACTGCTGGTGCCTG
TGGTGGTCGTACTACTGGCCGTGACCAGAGAGTGCATTTACAGAACGAGGAGGAAGAGAGAGAAAACGCAGGAGGGAGACAGACTGGCCA
GGCTGGTGGACACAGATACTGTTCTGGACTGTGCCTGTTAAGTTGCTCAGTTTTGAGCTGTCTTCAGACAAGAAGATTAAATAAATTTAT

>35258_35258_2_GTF2IRD1-ZAN_GTF2IRD1_chr7_73953090_ENST00000424337_ZAN_chr7_100389588_ENST00000546213_length(amino acids)=789AA_BP=530
MAAGRGRGAAGRSAWGSSKATMALLGKRCDVPTNGCGPDRWNSAFTRKDEIITSLVSALDSMCSALSKLNAEVACVAVHDESAFVVGTEK
GRMFLNARKELQSDFLRFCRGPPWKDPEAEHPKKVQRGEGGGRSLPRSSLEHGSDVYLLRKMVEEVFDVLYSEALGRASVVPLPYERLLR
EPGLLAVQGLPEGLAFRRPAEYDPKALMAILEHSHRIRFKLKRPLEDGGRDSKALVELNGVSLIPKGSRDCGLHGQAPKVPPQDLPPTAT
SSSMASFLYSTALPNHAIRELKQEAPSCPLAPSDLGLSRPMPEPKATGAQDFSDCCGQKPTGPGGPLIQNVHASKRILFSIVHDKSEKWD
AFIKETEDINTLRECVQILFNSRYAEALGLDHMVPVPYRKIACDPEAVEIVGIPDKIPFKRPCTYGVPKLKRILEERHSIHFIIKRMFDE
RIFTGNKFTKDTTKLEPASPPEDTSAEVSRATVLDLAGNARSDKGSMSEDCGPGTSGELGGLRPIKIEPEDLDIIQVTVPGLYQRRRRDK
GRSWASARASKCPNVARSSWRATAPRPVGCWQTPRAPLLPVTRRWPQSPSKSTACWICALLRTQESKRSCVARSSVGTPSSARRRALPWL
AGGTAPSALGSSFLTEDCSQRCTCASSRILLCEPFSCRAGEVCTLGNHTQGCFPESPCLQNPCQNDGQCREQGATFTCECEVGYGGGLCM

--------------------------------------------------------------
>35258_35258_3_GTF2IRD1-ZAN_GTF2IRD1_chr7_73953090_ENST00000455841_ZAN_chr7_100389588_ENST00000546213_length(transcript)=2680nt_BP=1837nt
GCCAGCCCCCCGGCCGGCCGATTCCCCCCCCGCGCCCCCTCCCCGCGCCTCCCTCCCCGCCCTCGCCGCGCCGCCGTCCTCGCCTCCCTC
TGCCTCTCCTTCCCCCATTCTCCCGGATTAATTAAGGAGGCAGCGGCAGGAGGCTGAGTCCTGGCCGCGGGCCGGGGCCGGGGCGCCGCT
GGCAGGAGCGCTTGGGGATCCTCCAAGGCGACCATGGCCTTGCTGGGTAAGCGCTGTGACGTCCCCACCAACGGCTGCGGACCCGACCGC
TGGAACTCCGCGTTCACCCGCAAAGACGAGATCATCACCAGCCTCGTGTCTGCCTTAGACTCCATGTGCTCAGCGCTGTCCAAACTGAAC
GCCGAGGTGGCCTGTGTCGCCGTGCACGATGAGAGCGCCTTTGTGGTGGGCACAGAGAAGGGGAGAATGTTCCTGAATGCCCGGAAGGAG
CTACAGTCAGACTTCCTCAGGTTCTGCCTCTCCGCAGCTCAGCACAGGGCAGCGACATCCCAGCTCGAAGGCCGGGTGGTGAGACGGGTG
CTCACTGTGGCCTCGCGTGCTCTGTGTCCCACAGGAGGGCCCCCGTGGAAGGATCCGGAGGCAGAGCACCCCAAGAAGGTGCAGCGGGGC
GAGGGTGGAGGCCGTAGCCTCCCTCGGTCCTCCCTGGAACATGGCTCAGATGTGTACCTTCTGCGGAAGATGGTAGAGGAGGTGTTTGAT
GTTCTTTATAGCGAGGCCCTGGGAAGGGCCAGTGTGGTGCCACTGCCCTATGAGAGGCTGCTCAGGGAGCCAGGGCTGCTGGCCGTGCAG
GGGCTGCCCGAAGGCCTGGCCTTCCGAAGGCCAGCCGAGTATGACCCCAAGGCCCTCATGGCCATCCTGGAACACAGCCACCGCATCCGC
TTCAAGCTCAAGAGGCCACTTGAGGATGGCGGGCGGGACTCGAAGGCCCTGGTGGAGCTGAACGGTGTCTCCCTGATTCCCAAGGGGTCA
CGGGACTGTGGCCTGCATGGCCAGGCCCCCAAGGTGCCACCCCAGGACCTGCCCCCAACCGCCACCTCCTCCTCCATGGCCAGCTTCCTG
TACAGCACGGCGCTCCCCAACCACGCCATCCGAGAGCTCAAGCAGGAAGCACCTTCCTGCCCCCTTGCCCCCAGCGACCTGGGCCTGAGT
CGGCCCATGCCAGAGCCCAAGGCCACCGGTGCCCAAGACTTCTCCGACTGTTGTGGACAGAAGCCCACTGGGCCTGGTGGGCCTCTCATC
CAGAACGTCCATGCCTCCAAGCGCATTCTCTTCTCCATCGTCCATGACAAGTCAGAGAAGTGGGACGCCTTCATAAAGGAAACCGAGGAC
ATCAACACGCTCCGGGAGTGTGTGCAGATCCTGTTTAACAGCAGATATGCGGAAGCCCTGGGCCTGGACCACATGGTCCCCGTGCCCTAC
CGGAAGATTGCCTGTGACCCGGAGGCTGTGGAGATCGTGGGCATCCCGGACAAGATCCCCTTCAAGCGCCCCTGCACTTATGGAGTCCCC
AAGCTGAAGCGGATCCTGGAGGAGCGCCATAGTATCCACTTCATCATTAAGAGGATGTTTGATGAGCGAATTTTCACAGGGAACAAGTTT
ACCAAAGACACCACGAAGCTGGAGCCAGCCAGCCCGCCAGAGGACACCTCTGCAGAGGTCTCTAGGGCCACCGTCCTTGACCTTGCTGGG
AATGCTCGGTCAGACAAGGGCAGCATGTCTGAAGACTGTGGGCCAGGAACCTCCGGGGAGCTGGGCGGGCTGAGGCCGATCAAAATTGAG
CCAGAGGATCTGGACATCATTCAGGTCACCGTCCCAGGGCTATACCAGCGGAGGAGGAGGGACAAGGGGCGGAGCTGGGCCTCCGCACGG
GCCTCCAAGTGTCCGAATGTAGCCCGGAGCAGCTGGCGAGCAACAGCACCCAGGCCTGTAGGGTGCTGGCAGACCCCCAGGGCCCCTTTG
CTGCCTGTCACCAGACGGTGGCCCCAGAGCCCTTCCAAGAGCACTGCGTGCTGGATCTGTGCTCTGCTCAGGACCCAAGAGAGCAAGAGG
AGCTGCGTTGCCAGGTCCTCAGTGGGTACGCCATCCTCTGCCAGGAGGCGGGCGCTGCCCTGGCTGGCTGGCGGGACCGCACCCTCTGCG
CTGGGCAGCAGCTTTCTGACTGAGGACTGCTCTCAGCGGTGCACCTGTGCCAGCTCACGGATCCTGCTGTGTGAGCCCTTCAGCTGCAGA
GCGGGGGAGGTCTGCACCCTGGGGAACCACACCCAAGGCTGCTTTCCAGAAAGCCCGTGTCTGCAGAACCCCTGTCAGAATGACGGGCAG
TGTCGGGAGCAGGGAGCCACCTTCACCTGCGAGTGTGAAGTTGGTTACGGGGGAGGCCTGTGTATGGAGCCTCGAGATGCGCCACCTCCC
AGAAAGCCAGAAGCATCTAACCTGGTGGGCGTCCTACTGGGACTGCTGGTGCCTGTGGTGGTCGTACTACTGGCCGTGACCAGAGAGTGC
ATTTACAGAACGAGGAGGAAGAGAGAGAAAACGCAGGAGGGAGACAGACTGGCCAGGCTGGTGGACACAGATACTGTTCTGGACTGTGCC

>35258_35258_3_GTF2IRD1-ZAN_GTF2IRD1_chr7_73953090_ENST00000455841_ZAN_chr7_100389588_ENST00000546213_length(amino acids)=821AA_BP=562
MAAGRGRGAAGRSAWGSSKATMALLGKRCDVPTNGCGPDRWNSAFTRKDEIITSLVSALDSMCSALSKLNAEVACVAVHDESAFVVGTEK
GRMFLNARKELQSDFLRFCLSAAQHRAATSQLEGRVVRRVLTVASRALCPTGGPPWKDPEAEHPKKVQRGEGGGRSLPRSSLEHGSDVYL
LRKMVEEVFDVLYSEALGRASVVPLPYERLLREPGLLAVQGLPEGLAFRRPAEYDPKALMAILEHSHRIRFKLKRPLEDGGRDSKALVEL
NGVSLIPKGSRDCGLHGQAPKVPPQDLPPTATSSSMASFLYSTALPNHAIRELKQEAPSCPLAPSDLGLSRPMPEPKATGAQDFSDCCGQ
KPTGPGGPLIQNVHASKRILFSIVHDKSEKWDAFIKETEDINTLRECVQILFNSRYAEALGLDHMVPVPYRKIACDPEAVEIVGIPDKIP
FKRPCTYGVPKLKRILEERHSIHFIIKRMFDERIFTGNKFTKDTTKLEPASPPEDTSAEVSRATVLDLAGNARSDKGSMSEDCGPGTSGE
LGGLRPIKIEPEDLDIIQVTVPGLYQRRRRDKGRSWASARASKCPNVARSSWRATAPRPVGCWQTPRAPLLPVTRRWPQSPSKSTACWIC
ALLRTQESKRSCVARSSVGTPSSARRRALPWLAGGTAPSALGSSFLTEDCSQRCTCASSRILLCEPFSCRAGEVCTLGNHTQGCFPESPC
LQNPCQNDGQCREQGATFTCECEVGYGGGLCMEPRDAPPPRKPEASNLVGVLLGLLVPVVVVLLAVTRECIYRTRRKREKTQEGDRLARL

--------------------------------------------------------------
>35258_35258_4_GTF2IRD1-ZAN_GTF2IRD1_chr7_73953090_ENST00000476977_ZAN_chr7_100389588_ENST00000546213_length(transcript)=4062nt_BP=3219nt
AACATTTAGCAGCAAACTCAACATACATTTTGGCCAAACGCCCACCGGCCAGTTGTTTAAATCAATATTTATCCACAGCCAAAAAGCAGA
GGAGAGCCAGAACTGAGGCCAGAGCCGAGCTCTGATGCATCTCTCATTTCTCGGGATGTTTCTGTCCCTGTGGTTGGACACCTCTGGCCT
TGTGAAGTGTGATGCACTGTCACATCTCCTGTTCTGTGTCATTGGCCAATGATCATATATCATGACCTGCTGGAAGGCCTGTCTGTGGCT
GGGACCACACGCCTTGGGCCTTATGCACACTGGGCACTGGTCGGGATCCTGGGGTGCAACAGTGGCAGGCAGACCTGGTTTCTGCCCTCA
AAGAGCTTACAGATGGCAGGGGCACCCATGGCGGCAGAAGACACCCCAGGCCTGGTGCCCTTTGTGGTGCCAGCCCCATGGTCCTCCTGC
CTGGGCCTTCCCTACCCCATTGGGTGCAGAAACTCCCTGTCTGCAGGTAGGAGACAGAGGGTAGGTTTTCAGGCTCCCTTGGGAACTGCA
GCCCTGCTCTCTGCCATCAACACCCAGCAGGGGCCACACAGAGAGCACCGGGACTGAGCCCATAGAGGGGAACCGAGAGGCCCCTGCCTC
TAGTCTCTGCCTTCTTTGCTTGGATTGGTGCAGGGACAGCTGCCTTGAGGGCAGGCCCTGGCACTGGGGCAGCCTGTGGGTGCCCCCTGG
GTCAAGAAGGAGAGGGGCAGGGTAGAACCAGGAGCCAAAGGAGGCTGATCTTTGCATCTCATGGGTGCCCAGCTGGACACTGTCATACCC
AGGAAGCCTGTGCCATGCCATGGGGACCCACAACTGGGGGCCCTGGACTTGAGGGGGAGGATGCAGCTCTGTCCCCCAGGAACCCCATTG
CAACAGGACACAGTCCTGCCCTGGGGAGCCCCTGACCTGAGACAAAGCAGCCTCGGCCCTGCTGTATCTTTCCATACCCCTGATGCCAAG
TCTCCTGGCTAGGAGGGAAACTGAGGCTGGAAGGCCTCGGCGGGGGTGGCATTGGCCTCGGGAGCATGTGGCTTGATGCAGAAATGTGAC
GGCAGAGCTCAGAGGCATGCGGAAGGGAGGGGAGGACATCACCGGCTCCTGACCCAGCTGGGCTTCAGGTTGGGGGTACAGGAGGTGGGC
AAGCAGGTTGGACAATTAAAAGCTTCGATGAGGCTGGGTGAGTGGCTTATGCCTGTATTTCCAACACTTTGGGAGGCTGAGGTGGGCAGA
TCACCTGAGGCCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGACGTGTGGT
GGCACCTGTAATCCCAGCTACCCGGGAGGCTGAGGCAGGAGAATCACTCGAACCCAGGAAGGGGAGGTTGCAGTGAGCCAAGATTGCACC
ACTGCACTATAGCCTGGGCAACAGAGTGAGACTCTGTCTCGAAATAAAATTAAATTTAAAATTTAAAAAAGCTTCAAGGACAACCAGCAG
ATGATGGCAGGACCAGGAAGGGTGCTTCAGGCAGCGGGAACTGAACCTGCACAGACTAGGGAAGCATGAACATCGGTACATCTGGGAGTG
GCACAGCTTAGAGGGCCTGGAGCATGGAGTGTGAGGGGGAACTGGAGTGAGGGACAGGAGACCAGGCGACCATGGCCTTGCTGGGTAAGC
GCTGTGACGTCCCCACCAACGGCTGCGGACCCGACCGCTGGAACTCCGCGTTCACCCGCAAAGACGAGATCATCACCAGCCTCGTGTCTG
CCTTAGACTCCATGTGCTCAGCGCTGTCCAAACTGAACGCCGAGGTGGCCTGTGTCGCCGTGCACGATGAGAGCGCCTTTGTGGTGGGCA
CAGAGAAGGGGAGAATGTTCCTGAATGCCCGGAAGGAGCTACAGTCAGACTTCCTCAGGTTCTGCCGAGGGCCCCCGTGGAAGGATCCGG
AGGCAGAGCACCCCAAGAAGGTGCAGCGGGGCGAGGGTGGAGGCCGTAGCCTCCCTCGGTCCTCCCTGGAACATGGCTCAGATGTGTACC
TTCTGCGGAAGATGGTAGAGGAGGTGTTTGATGTTCTTTATAGCGAGGCCCTGGGAAGGGCCAGTGTGGTGCCACTGCCCTATGAGAGGC
TGCTCAGGGAGCCAGGGCTGCTGGCCGTGCAGGGGCTGCCCGAAGGCCTGGCCTTCCGAAGGCCAGCCGAGTATGACCCCAAGGCCCTCA
TGGCCATCCTGGAACACAGCCACCGCATCCGCTTCAAGCTCAAGAGGCCACTTGAGGATGGCGGGCGGGACTCGAAGGCCCTGGTGGAGC
TGAACGGTGTCTCCCTGATTCCCAAGGGGTCACGGGACTGTGGCCTGCATGGCCAGGCCCCCAAGGTGCCACCCCAGGACCTGCCCCCAA
CCGCCACCTCCTCCTCCATGGCCAGCTTCCTGTACAGCACGGCGCTCCCCAACCACGCCATCCGAGAGCTCAAGCAGGAAGCACCTTCCT
GCCCCCTTGCCCCCAGCGACCTGGGCCTGAGTCGGCCCATGCCAGAGCCCAAGGCCACCGGTGCCCAAGACTTCTCCGACTGTTGTGGAC
AGAAGCCCACTGGGCCTGGTGGGCCTCTCATCCAGAACGTCCATGCCTCCAAGCGCATTCTCTTCTCCATCGTCCATGACAAGTCAGAGA
AGTGGGACGCCTTCATAAAGGAAACCGAGGACATCAACACGCTCCGGGAGTGTGTGCAGATCCTGTTTAACAGCAGATATGCGGAAGCCC
TGGGCCTGGACCACATGGTCCCCGTGCCCTACCGGAAGATTGCCTGTGACCCGGAGGCTGTGGAGATCGTGGGCATCCCGGACAAGATCC
CCTTCAAGCGCCCCTGCACTTATGGAGTCCCCAAGCTGAAGCGGATCCTGGAGGAGCGCCATAGTATCCACTTCATCATTAAGAGGATGT
TTGATGAGCGAATTTTCACAGGGAACAAGTTTACCAAAGACACCACGAAGCTGGAGCCAGCCAGCCCGCCAGAGGACACCTCTGCAGAGG
TCTCTAGGGCCACCGTCCTTGACCTTGCTGGGAATGCTCGGTCAGACAAGGGCAGCATGTCTGAAGACTGTGGGCCAGGAACCTCCGGGG
AGCTGGGCGGGCTGAGGCCGATCAAAATTGAGCCAGAGGATCTGGACATCATTCAGGTCACCGTCCCAGGGCTATACCAGCGGAGGAGGA
GGGACAAGGGGCGGAGCTGGGCCTCCGCACGGGCCTCCAAGTGTCCGAATGTAGCCCGGAGCAGCTGGCGAGCAACAGCACCCAGGCCTG
TAGGGTGCTGGCAGACCCCCAGGGCCCCTTTGCTGCCTGTCACCAGACGGTGGCCCCAGAGCCCTTCCAAGAGCACTGCGTGCTGGATCT
GTGCTCTGCTCAGGACCCAAGAGAGCAAGAGGAGCTGCGTTGCCAGGTCCTCAGTGGGTACGCCATCCTCTGCCAGGAGGCGGGCGCTGC
CCTGGCTGGCTGGCGGGACCGCACCCTCTGCGCTGGGCAGCAGCTTTCTGACTGAGGACTGCTCTCAGCGGTGCACCTGTGCCAGCTCAC
GGATCCTGCTGTGTGAGCCCTTCAGCTGCAGAGCGGGGGAGGTCTGCACCCTGGGGAACCACACCCAAGGCTGCTTTCCAGAAAGCCCGT
GTCTGCAGAACCCCTGTCAGAATGACGGGCAGTGTCGGGAGCAGGGAGCCACCTTCACCTGCGAGTGTGAAGTTGGTTACGGGGGAGGCC
TGTGTATGGAGCCTCGAGATGCGCCACCTCCCAGAAAGCCAGAAGCATCTAACCTGGTGGGCGTCCTACTGGGACTGCTGGTGCCTGTGG
TGGTCGTACTACTGGCCGTGACCAGAGAGTGCATTTACAGAACGAGGAGGAAGAGAGAGAAAACGCAGGAGGGAGACAGACTGGCCAGGC
TGGTGGACACAGATACTGTTCTGGACTGTGCCTGTTAAGTTGCTCAGTTTTGAGCTGTCTTCAGACAAGAAGATTAAATAAATTTATATA

>35258_35258_4_GTF2IRD1-ZAN_GTF2IRD1_chr7_73953090_ENST00000476977_ZAN_chr7_100389588_ENST00000546213_length(amino acids)=768AA_BP=509
MALLGKRCDVPTNGCGPDRWNSAFTRKDEIITSLVSALDSMCSALSKLNAEVACVAVHDESAFVVGTEKGRMFLNARKELQSDFLRFCRG
PPWKDPEAEHPKKVQRGEGGGRSLPRSSLEHGSDVYLLRKMVEEVFDVLYSEALGRASVVPLPYERLLREPGLLAVQGLPEGLAFRRPAE
YDPKALMAILEHSHRIRFKLKRPLEDGGRDSKALVELNGVSLIPKGSRDCGLHGQAPKVPPQDLPPTATSSSMASFLYSTALPNHAIREL
KQEAPSCPLAPSDLGLSRPMPEPKATGAQDFSDCCGQKPTGPGGPLIQNVHASKRILFSIVHDKSEKWDAFIKETEDINTLRECVQILFN
SRYAEALGLDHMVPVPYRKIACDPEAVEIVGIPDKIPFKRPCTYGVPKLKRILEERHSIHFIIKRMFDERIFTGNKFTKDTTKLEPASPP
EDTSAEVSRATVLDLAGNARSDKGSMSEDCGPGTSGELGGLRPIKIEPEDLDIIQVTVPGLYQRRRRDKGRSWASARASKCPNVARSSWR
ATAPRPVGCWQTPRAPLLPVTRRWPQSPSKSTACWICALLRTQESKRSCVARSSVGTPSSARRRALPWLAGGTAPSALGSSFLTEDCSQR
CTCASSRILLCEPFSCRAGEVCTLGNHTQGCFPESPCLQNPCQNDGQCREQGATFTCECEVGYGGGLCMEPRDAPPPRKPEASNLVGVLL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GTF2IRD1-ZAN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for GTF2IRD1-ZAN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for GTF2IRD1-ZAN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGTF2IRD1C0175702Williams Syndrome1CTD_human
HgeneGTF2IRD1C0376634Craniofacial Abnormalities1CTD_human