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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CLOCK-PHF21A (FusionGDB2 ID:HG9575TG51317)

Fusion Gene Summary for CLOCK-PHF21A

Fusion gene summary

Fusion gene information	Fusion gene name: CLOCK-PHF21A
	Fusion gene ID: hg9575tg51317
		Hgene	Tgene
	Gene symbol	CLOCK	PHF21A
	Gene ID	9575	51317
	Gene name	clock circadian regulator	PHD finger protein 21A
	Synonyms	KAT13D\|bHLHe8	BHC80\|BM-006\|IDDBCS\|NEDMS
	Cytomap	('CLOCK')('PHF21A') 4q12	11p11.2
	Type of gene	protein-coding	protein-coding
	Description	circadian locomoter output cycles protein kaputcircadian locomoter output cycles kaput proteinclass E basic helix-loop-helix protein 8clock homolog	PHD finger protein 21ABHC80aBRAF35-HDAC complex protein BHC80BRAF35/HDAC2 complex (80 kDa)
	Modification date	20200313	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000309964, ENST00000381322, ENST00000513440, ENST00000506923,
Fusion gene scores	* DoF score	10 X 13 X 6=780	13 X 10 X 8=1040
	# samples	14	14
	** MAII score	log2(14/780*10)=-2.47804729680464 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/1040*10)=-2.89308479608349 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CLOCK [Title/Abstract] AND PHF21A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CLOCK(56319221)-PHF21A(46001517), # samples:2
Anticipated loss of major functional domain due to fusion event.	CLOCK-PHF21A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CLOCK-PHF21A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CLOCK-PHF21A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CLOCK-PHF21A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CLOCK-PHF21A seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. CLOCK-PHF21A seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. CLOCK-PHF21A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CLOCK-PHF21A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. CLOCK-PHF21A seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. CLOCK-PHF21A seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. CLOCK-PHF21A seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CLOCK	GO:0006473	protein acetylation	28985504
Hgene	CLOCK	GO:0032922	circadian regulation of gene expression	24005054
Hgene	CLOCK	GO:0045893	positive regulation of transcription, DNA-templated	23785138
Hgene	CLOCK	GO:0051775	response to redox state	11441146
Hgene	CLOCK	GO:0071479	cellular response to ionizing radiation	21659603

Fusion gene breakpoints across CLOCK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PHF21A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-38-4631-01A	CLOCK	chr4	56319221	-	PHF21A	chr11	46001517	-

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Fusion Gene ORF analysis for CLOCK-PHF21A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000309964	ENST00000527753	CLOCK	chr4	56319221	-	PHF21A	chr11	46001517	-
5CDS-intron	ENST00000381322	ENST00000527753	CLOCK	chr4	56319221	-	PHF21A	chr11	46001517	-
5CDS-intron	ENST00000513440	ENST00000527753	CLOCK	chr4	56319221	-	PHF21A	chr11	46001517	-
Frame-shift	ENST00000381322	ENST00000257821	CLOCK	chr4	56319221	-	PHF21A	chr11	46001517	-
Frame-shift	ENST00000381322	ENST00000323180	CLOCK	chr4	56319221	-	PHF21A	chr11	46001517	-
Frame-shift	ENST00000381322	ENST00000418153	CLOCK	chr4	56319221	-	PHF21A	chr11	46001517	-
Frame-shift	ENST00000513440	ENST00000257821	CLOCK	chr4	56319221	-	PHF21A	chr11	46001517	-
Frame-shift	ENST00000513440	ENST00000323180	CLOCK	chr4	56319221	-	PHF21A	chr11	46001517	-
Frame-shift	ENST00000513440	ENST00000418153	CLOCK	chr4	56319221	-	PHF21A	chr11	46001517	-
In-frame	ENST00000309964	ENST00000257821	CLOCK	chr4	56319221	-	PHF21A	chr11	46001517	-
In-frame	ENST00000309964	ENST00000323180	CLOCK	chr4	56319221	-	PHF21A	chr11	46001517	-
In-frame	ENST00000309964	ENST00000418153	CLOCK	chr4	56319221	-	PHF21A	chr11	46001517	-
intron-3CDS	ENST00000506923	ENST00000257821	CLOCK	chr4	56319221	-	PHF21A	chr11	46001517	-
intron-3CDS	ENST00000506923	ENST00000323180	CLOCK	chr4	56319221	-	PHF21A	chr11	46001517	-
intron-3CDS	ENST00000506923	ENST00000418153	CLOCK	chr4	56319221	-	PHF21A	chr11	46001517	-
intron-intron	ENST00000506923	ENST00000527753	CLOCK	chr4	56319221	-	PHF21A	chr11	46001517	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000309964	CLOCK	chr4	56319221	-	ENST00000257821	PHF21A	chr11	46001517	-	7998	1457	251	3349	1032
ENST00000309964	CLOCK	chr4	56319221	-	ENST00000323180	PHF21A	chr11	46001517	-	4611	1457	251	3208	985
ENST00000309964	CLOCK	chr4	56319221	-	ENST00000418153	PHF21A	chr11	46001517	-	3834	1457	251	3346	1031

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000309964	ENST00000257821	CLOCK	chr4	56319221	-	PHF21A	chr11	46001517	-	0.00015162	0.99984837
ENST00000309964	ENST00000323180	CLOCK	chr4	56319221	-	PHF21A	chr11	46001517	-	0.000292267	0.99970776
ENST00000309964	ENST00000418153	CLOCK	chr4	56319221	-	PHF21A	chr11	46001517	-	0.000647218	0.99935275

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Fusion Genomic Features for CLOCK-PHF21A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for CLOCK-PHF21A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:56319221/chr11:46001517)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000309964

107_177

402

847.0

Domain

PAS 1

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000309964

262_332

402

847.0

Domain

PAS 2

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000309964

336_379

402

847.0

Domain

Note=PAC

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000309964

34_84

402

847.0

Domain

bHLH

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000381322

107_177

402

847.0

Domain

PAS 1

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000381322

262_332

402

847.0

Domain

PAS 2

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000381322

336_379

402

847.0

Domain

Note=PAC

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000381322

34_84

402

847.0

Domain

bHLH

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000513440

107_177

402

847.0

Domain

PAS 1

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000513440

262_332

402

847.0

Domain

PAS 2

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000513440

336_379

402

847.0

Domain

Note=PAC

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000513440

34_84

402

847.0

Domain

bHLH

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000309964

32_47

402

847.0

Motif

Nuclear localization signal

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000381322

32_47

402

847.0

Motif

Nuclear localization signal

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000513440

32_47

402

847.0

Motif

Nuclear localization signal

Tgene

PHF21A

chr4:56319221

chr11:46001517

ENST00000257821

558_603

682.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PHF21A

chr4:56319221

chr11:46001517

ENST00000323180

558_603

635.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PHF21A

chr4:56319221

chr11:46001517

ENST00000418153

558_603

681.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PHF21A

chr4:56319221

chr11:46001517

ENST00000257821

425_437

682.0

DNA binding

Note=A.T hook

Tgene

PHF21A

chr4:56319221

chr11:46001517

ENST00000323180

425_437

635.0

DNA binding

Note=A.T hook

Tgene

PHF21A

chr4:56319221

chr11:46001517

ENST00000418153

425_437

681.0

DNA binding

Note=A.T hook

Tgene

PHF21A

chr4:56319221

chr11:46001517

ENST00000257821

486_680

682.0

Region

Note=Required for transcriptional repression

Tgene

PHF21A

chr4:56319221

chr11:46001517

ENST00000323180

486_680

635.0

Region

Note=Required for transcriptional repression

Tgene

PHF21A

chr4:56319221

chr11:46001517

ENST00000418153

486_680

681.0

Region

Note=Required for transcriptional repression

Tgene

PHF21A

chr4:56319221

chr11:46001517

ENST00000257821

488_535

682.0

Zinc finger

PHD-type

Tgene

PHF21A

chr4:56319221

chr11:46001517

ENST00000323180

488_535

635.0

Zinc finger

PHD-type

Tgene

PHF21A

chr4:56319221

chr11:46001517

ENST00000418153

488_535

681.0

Zinc finger

PHD-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000309964

744_760

402

847.0

Compositional bias

Note=Gln-rich

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000309964

819_828

402

847.0

Compositional bias

Note=Poly-Gln

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000381322

744_760

402

847.0

Compositional bias

Note=Gln-rich

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000381322

819_828

402

847.0

Compositional bias

Note=Poly-Gln

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000513440

744_760

402

847.0

Compositional bias

Note=Gln-rich

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000513440

819_828

402

847.0

Compositional bias

Note=Poly-Gln

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000309964

514_564

402

847.0

Region

Implicated in the circadian rhythmicity

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000381322

514_564

402

847.0

Region

Implicated in the circadian rhythmicity

Hgene

CLOCK

chr4:56319221

chr11:46001517

ENST00000513440

514_564

402

847.0

Region

Implicated in the circadian rhythmicity

Tgene

PHF21A

chr4:56319221

chr11:46001517

ENST00000257821

4_108

682.0

Compositional bias

Note=Gln-rich

Tgene

PHF21A

chr4:56319221

chr11:46001517

ENST00000323180

4_108

635.0

Compositional bias

Note=Gln-rich

Tgene

PHF21A

chr4:56319221

chr11:46001517

ENST00000418153

4_108

681.0

Compositional bias

Note=Gln-rich

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Fusion Gene Sequence for CLOCK-PHF21A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>17273_17273_1_CLOCK-PHF21A_CLOCK_chr4_56319221_ENST00000309964_PHF21A_chr11_46001517_ENST00000257821_length(transcript)=7998nt_BP=1457nt
AGCTGATTCTATCACATTGTAAGATGCCTTTGGATAATTCTACAGTCCTCTTAAATGAATCTTTAGAACTTGGCAAGTCTCACTAGATAC
CTTCAATCATCATTTTGAGCTCAAAGAATTCTGAGACTTATGGTTGGTCATATAGAAGAGTACCTTGAACCTATAGTTTCCTGAAGAATC
AGTTTAAAAGATCCAAGGAGTACAAAAGGAGAAGTACAAATGTCTACTACAAGACGAAAACGTAGTATGTTATGTTGTTTACCGTAAGCT
GTAGTAAAATGAGCTCGATTGTTGACAGAGATGACAGTAGTATTTTTGATGGGTTGGTGGAAGAAGATGACAAGGACAAAGCGAAAAGAG
TATCTAGAAACAAATCTGAAAAGAAACGTAGAGATCAATTTAATGTTCTCATTAAAGAACTGGGATCCATGCTTCCTGGTAATGCTAGAA
AGATGGACAAATCTACTGTTCTGCAGAAAAGCATTGATTTTTTACGAAAACATAAAGAAATCACTGCACAGTCAGATGCTAGTGAAATTC
GACAGGACTGGAAACCTACATTCCTTAGTAATGAAGAGTTTACACAATTAATGTTAGAGGCTCTTGATGGTTTTTTTTTAGCAATCATGA
CAGATGGAAGCATAATATATGTGTCTGAGAGTGTAACTTCATTACTTGAACATTTACCATCTGATCTTGTGGATCAAAGTATATTTAATT
TTATCCCAGAAGGGGAACATTCAGAGGTTTATAAAATACTCTCTACTCATCTGCTGGAAAGTGATTCATTAACCCCAGAATATTTAAAAT
CAAAAAATCAGTTAGAATTCTGTTGTCACATGCTGCGAGGAACAATAGACCCAAAGGAGCCATCTACCTATGAATATGTAAAATTTATAG
GAAATTTCAAATCTTTAAACAGTGTATCCTCTTCAGCACACAATGGTTTTGAAGGAACTATACAACGCACACATAGGCCATCTTATGAAG
ATAGAGTTTGTTTTGTAGCTACTGTCAGGTTAGCTACACCTCAGTTCATCAAGGAAATGTGCACTGTTGAAGAACCCAATGAAGAGTTTA
CATCTAGACATAGTTTAGAATGGAAGTTTCTGTTTCTAGATCACAGGGCACCACCCATAATAGGGTATTTGCCATTTGAAGTTCTGGGAA
CATCAGGCTATGATTACTATCATGTGGATGACCTAGAAAATTTGGCAAAATGTCATGAGCACTTAATGCAATATGGGAAAGGCAAATCAT
GTTATTATAGGTTCCTGACTAAGGGGCAACAGTGGATTTGGCTTCAGACTCATTATTATATCACTTACCATCAGTGGAATTCAAGGCCAG
AGTTTATTGTTTGTACTCACACTGTAGTAAGTTATGCAGAAGTTAGGGCTGAAAGACGACGAGAACTTGGCATTGAAGAGTCTCTTCCTG
AGACAGCTGCTGACAAAAAAAGAGTAGTTGAACAGCTACGGAAGAACCTGATAGTAAAGCAAGAACAACCGGACAAGTTCCAAATACAGC
CATTGCCACAATCTGAAAACAAACTACAAACAGCACAGCAGCAACCACTACAGCAACTACAACAACAGCAGCAGTACCACCACCACCACG
CCCAGCAGTCAGCTGCAGCCTCTCCCAACCTGACTGCTTCACAGAAGACTGTAACTACAGCTTCTATGATTACCACAAAGACACTACCTC
TCGTCTTGAAAGCAGCAACTGCGACCATGCCTGCCTCTGTGGTGGGCCAGAGACCTACCATTGCTATGGTGACCGCCATCAACAGTCAGA
AGGCTGTGCTCAGCACTGATGTGCAGAACACACCAGTCAACCTCCAGACGTCTAGTAAGGTCACTGGGCCTGGGGCAGAGGCTGTCCAAA
TTGTGGCAAAAAACACAGTCACTCTGCAGGTTCAGGCAACACCTCCTCAGCCCATCAAAGTACCACAGTTTATCCCCCCTCCTAGACTCA
CTCCACGTCCAAACTTTCTTCCACAGGTTCGACCCAAGCCTGTGGCCCAGAATAACATTCCTATTGCCCCAGCACCACCTCCCATGCTCG
CAGCTCCTCAGCTTATCCAGAGGCCCGTCATGCTGACCAAGTTCACCCCCACAACCCTTCCCACATCCCAGAATTCCATCCACCCCGTCC
GTGTCGTCAATGGGCAGACTGCAACCATAGCCAAAACGTTCCCCATGGCCCAGCTCACCAGCATTGTGATAGCTACTCCAGGGACCAGAC
TCGCTGGACCTCAAACTGTACAGCTTAGCAAGCCAAGTCTTGAAAAACAGACAGTTAAATCTCACACAGAAACAGATGAGAAACAAACAG
AGAGCCGCACCATCACCCCACCTGCTGCACCCAAACCAAAACGGGAGGAGAACCCTCAGAAACTTGCCTTCATGGTGTCTCTAGGGTTGG
TAACACATGACCATCTAGAAGAAATCCAAAGCAAGAGGCAAGAGCGAAAAAGAAGAACAACAGCAAATCCGGTCTACAGTGGAGCAGTCT
TTGAGCCAGAGCGTAAGAAGAGTGCAGTGACATACCTAAACAGCACAATGCACCCTGGGACCCGGAAGAGAGGTCGTCCTCCAAAATACA
ATGCAGTGCTGGGGTTTGGAGCCCTTACCCCAACATCCCCCCAATCCAGTCATCCTGACTCCCCTGAAAATGAAAAGACAGAGACCACAT
TCACTTTCCCTGCACCTGTTCAGCCTGTGTCCCTGCCCAGCCCCACCTCCACAGACGGTGATATTCATGAGGATTTTTGCAGCGTTTGCA
GAAAAAGTGGCCAGTTACTGATGTGCGACACATGTTCCCGTGTATATCATTTGGACTGCTTAGACCCCCCTCTGAAAACAATTCCCAAGG
GCATGTGGATCTGTCCCAGATGTCAGGACCAGATGCTGAAGAAGGAAGAAGCAATTCCATGGCCTGGAACTTTAGCAATTGTTCATTCCT
ATATTGCCTACAAAGCAGCAAAAGAAGAAGAGAAACAGAAGTTACTTAAATGGAGTTCAGATTTAAAACAAGAACGAGAACAACTAGAGC
AAAAGGTGAAACAGCTCAGCAATTCCATAAGTAAATGCATGGAAATGAAGAACACCATCCTGGCCCGGCAGAAGGAGATGCACAGCTCCC
TGGAGAAGGTAAAACAGCTGATTCGCCTCATCCACGGCATCGACCTCTCCAAACCTGTAGACTCTGAGGCCACTGTGGGGGCCATCTCCA
ATGGCCCGGACTGCACCCCCCCTGCCAATGCCGCCACCTCCACGCCGGCCCCTTCCCCCTCCTCCCAGAGCTGCACAGCGAACTGTAACC
AGGGGGAAGAGACTAAATAACAGAGCCCCTCTAGGAGAAGCCACGGGATCCCGGCGGCAAGGAGAACAGAACACTGAAGACTCTAGAAAA
GCAAAGCCGGATTTCTGGAAAGTGCAGAATTCTTTTGGTTCTTTGGTTCCAGAGAGAGAGAAGATGCTTGTGCCAGGTGGCACCAGAGTT
TGCCAATTGATCCTTCTTATTCTGTGTGTACATGCAAAGATTGGACCATGTTACATGAAATAGTGCCAGCTGGAGGTTCTTTGCCAGCAC
CATGCCAAGTGAAATAATATATTTACTCTCTCTATTATACACCAGTGTGTGCCTGCAGCAGCCTCCACAGCCACGATGGGTTTGTTTCTG
TTTTCTTGGGTGGGGAGCAGGGACGGGCGGAGGGAGGAGAGCAGGTTTCAGATCCTTACTTGCCGAGCCGTTTGTTTAGGTAGAGAAGAC
AAGTCCAAAGAGTGTGTGGGCTTTCCTGTTTCTAAACTTTCGCTACTATAAAACCAAAAAAAGGAATTGAGATTTCACCAACCCCAGTGC
CCAGAAGAGGGAAGGGGAGTGGCTGGAGGGAGCAGGGGGTGGGACAGTGTATCAAATAAGCAGTATTTAATCACCTCTGGCGGGGGCCTC
GTGCAAGGGGAGACTGACACCAAGAACAGCCAGTAGGTTCTTCTCCCCTGCACTCTGCTCCCTGCGCGGTAACCCCACCACTCCTGAAGC
CTGCCCAGTCTCCTTCCTTCCCTGCTTGGTGAGTCGCGCATCTCCGTGGTTATCCCGCTGTCTCCTCTCCAAGAACAAGCAGAGCCCGGG
CCACTGGCCCTTGCCCAAGGCAGGGAAGAAGGATGTGTGTGTCCAGGAAGGAAAAAAAGGTGGATCAGTGATTTTACTTGAAAACAAGCT
CCATCCCTTTTCTATATTTATAAGAAGAGAAGATCTTGAGTGAAGCAGCACGCGACCCAGGTGTGTGTGAATTGAATGGAGACGTTTCTT
TTCTCTTTCTTTAATTTTTGTTTTTGTTCTTTTTTTCTTTAAGGAAAGTTTTATTTTACTGTTCATTTTACTTTCTTGGTAACAAAAACT
AAAATAAGGAATAGAAAAGCTGTTTTTCAGGCTGACAGTCCAATTAAGGGTAGCCAAGACCTTGCATGGTAGAGTAGGAATCATAGTGTC
AGTGAGGTCCCGTGAGTCTTTGTGAGTCCTTGTGTCATCGTTCGGGCACTGTTTTTTTATGCAAGGGCAAAAATCTTTGTATCTGGGGAA
AAAAAACTTTTTTTTAAATTAAAAAGGAAAATAAAAGATATTGAGGTCTTCCTAGTGTTACTTAAATTAAGATCAAGGTAAGAAACATTG
TAAAAAAAAATTACAAAAGTGCTATTTGTTTCCTAAAAACAGTGATTTCTATTAAAAAGGTGTCAGAACTGGAGAAAATGCCGTGTAGTT
ATAATTTTTTAGCACAGACCCTGCTGATCACGATGACATTTTGCCGTGTGTGTGTCTCTAGACTGGTGGGCCAGTCTCCTTGAAGGACAG
AGGCGGAGCTCCCCACCCTTCTCTCTCCTCAGAAAAGACCGTGCTCTCTTCTTGGTGCAGGGATCTTGTCTCCTGTTGTGAAGCCCAAAT
GGAAGCGTGGATGGTATCAGGGCCCTACCCGTGGTCTTCTCAGATTCTGCTAGAGCAAAAGGCTGGTGCCTAAATAAGATCCCTTCCTTT
GGTGCTGCTTTTGGTCTTTCAGCCACCAGCATTATGAGTGCCTGGGGGACACCTCCGAGGGAACTGGCCAGCGGAGCTCTGTGGTGCGCA
CGCACCCTGGCCGTGACAGGAGGGTGCGGGAGTACAGGCTGGCTGCATCAGCCCTTGGTGCTTAGAACAGAGGAGGAGTGACATGTTTTG
AGGGTACGTCTCTGAGACAGAGCCCCAGCGTGGCCTTCGCTCTGTCTTGCCTTTGGGGAGAGGTCTGAAGCTCCCACTCCTTTCTCTGCC
TGTTGGCTCCAGGCACCAGAAATTTACTCCACTCCACCCACCCACAAGCCTCCTGGGTGACCCTGGGCTAGAATTGCTGCGCTTGCCTCG
GCTTGGCCGGTTGTGGCCTCTCCTTGAGAAAACCAGGGTTGTGAAAGACTCAGACCATTCTCTCATCTTGCCTTGTCAGAAGTAAATTGT
GTCAGATTTGTGCTCTCGCTGGAGACCTTTGCCCCTTGCGTGCCCCTGGCCGATGGGAGGGCGGTGGAGGCTCTGTACCCTGGCCCTGCT
GGAGCATCTCCCCCAAGCCCACTCCAGGCCCTGGGAATGGCCAGAGTCTAGGAGAGGTAGAAACGATCCTATCAGCTTCTCTCCCACCCA
ATTAGGCCCAGAGAGACAAAGACAGATCTGAAAGCAAATGCAACAGAGAAGAGACACTTCTTAGAGTAAAATGTGTCTCATCTCTATCAG
CCATCGCCTTTCATCTTCCCAGGGGCCTCAGAAGAAGGAATTAAGTTAGGCTGAACAGGCCTCAGAGTTAGGCCCTGGCTGCTTGATTGG
CTGAGGGGGAAAGAGTTCCCTTTTCTCATTCAGAAACCAAGGTGCTGTGTCTAGTCAGGGAGCCTTGGAGATGCCTGGACTAGTTGGAGG
AATCGTTGGCAGAGGATCAGAGACCAGCAGCAGGCTGTCTGCCCTGTCTAGAGCTCTTCCCCTCAACTTGTCTGGGCCCATCTGGGGGTT
GCCACACAACACCTAACTTACCTTTTCCTGAAAGAAGTTGGGAAACCATCATCACTAGAGGCCTTTGCTCAGAGAGGAGCTGCCTTAGGA
GTCTTGGGTCGGAGGACGGGGCTAGGAATTGACCAGGGCTTTGCCTGCCGCCCTCAGCAGTGTCGGGTACATTCTGACCTCGCCTGCAGC
TGGGCTGTGGATTCTTCCTGACATTCAGATGTGAGCTGTTTTGGGAGTCAGCTAGTATGGAGTACGAGATGCAACCCAGCCCCCAAACCT
ACATTCTGCACTCAAATTCCAAAACACTGCTTTACTGTAAAGAAGAGGCCCCTGGCACCCAATCTCCCTGTCCTTCACTGTCCCCTCAGA
CCTGGGCGGGGAGGGGGGGGGGCCTGTGACCACCTGAGACATACGCTCGTGACACTGCCCCACCCCAGCCACCTCCACTTGCTTCCTCCT
CCTTCCCTCCGCTGCTCTTTCCCCACGGCCCAGAATTTAGCTGCTCTGACAGCCACTTTTGAGACCAGCTGGCTTTGTAGTCACTTCAGA
GAGCTGGAGCGGCTGCCCACTGGGCCCTGACTGGGAGTCCCCTGCCAGCTCCTGATCAGGCGCTGCGCCCTGGTGGCAGTGATGACTGGG
AGTCCCCTGCCAGCTCCTGTCCAGGCGCTGCATCCTGGTAACAGTGAGGCCATGTTGCTGTCATCTCCACCTCTGCATTCTTGCTGCCTG
TGGGTCCTTTTTCTTTCATGGAGCCTGCTGGGTCTTGTCTCACCTGTGCTGAGCTCCTCTGGGGTTTTGATTTCTTCCTTCCTTATCAGG
CCCTTTGGGGTAAGCCTGCTGGTTGTACCTGACATAGGGAGGCAGTTAGGGGCAGTCCCTGGTGGGGCCGCCCTGGCAGCCTCCAGCTGG
CACCATCGTGTGCCTGGTTTCCCTGCAACACCTGCCTCTCTGTCCCTGCTGCTGCTTGGCTCAGGCCCAACAGGCAGCGTGCATGGAGGT
GGTTACACACAGCTGTTTCCGTGAGGGTGACCGTGTCTGCAGCACGCTTCCGTCTCCGCATGCACGGCTGCCTCTCCAGCCACCTCTGAT
ACTTCTCTCTTGGGGCCATCAGAGCCTCCCTTGGGCTGTCACCTCCCAGCTCACACACACTCTTCAGTGGTTTCCTCTCTTCATTCTCTT
ATAGGGCGTGGTCCTTCTTATTTATCTAAAGGGCTGAATTTAGGAGACTTTTTACCCAGGGGCAAAAGGCTCTTAGGGTAATGAGATGGA
TGGTGGCCCAGGTGCATTTTCCAGGGCCTGGGTTCTCCAGATCCCGTGGCTTCTGTTGAGTGGAGGCAACTTTGCTCTGTGTGAACCTCG
CCCCTGTCCCTCTGCCGGGCACCCCTGGCAGGAAGCAGGACTCCCATCCTCACCCTGACTTAGACTGTCCTCTGAGTCAGCTCCTCTCCA
AGACAGGAGTGGGCAGCCCTGGGCAGTCTTCTGGCCCCTTGCTAAAGTGAGGGGCAGGAAGCTGGGGCTGCCCTCCAGAAAGCCGGGGTA
GGAACTCTGAAAAATACCTCCTCTAAACGGAAGCAGGGCTCTCCAGTTCCACTTGGCGCCCCCTCCCACAAGGCCCTTCCTCCCTGAGGA
CCCCACCCCCCTACCCCTTCCCCAGCAGCCTTTGGACCCTCACCTCTCTCCGGTGTCCGTGGGTCCTCAGCCCAGGGTGAGCTGCAGTCA
GGCGGGATGGGACGGGCAGGCCAGAGGTCAGCCAGCTCCTAGCAGAGAAGAGCCAGCCAGACCCCAACCCTGTCTCTTGTCCATGCCCTT
TGTGATTTCAGTCTTGGTAGACTTGTATTTGGAGTTTTGTGCTTCAAAGTTTTTGTTTTTGTTTGTTTGGTTTTTGTTTTGAGGGGGTGG

>17273_17273_1_CLOCK-PHF21A_CLOCK_chr4_56319221_ENST00000309964_PHF21A_chr11_46001517_ENST00000257821_length(amino acids)=1032AA_BP=402
MLFTVSCSKMSSIVDRDDSSIFDGLVEEDDKDKAKRVSRNKSEKKRRDQFNVLIKELGSMLPGNARKMDKSTVLQKSIDFLRKHKEITAQ
SDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSL
TPEYLKSKNQLEFCCHMLRGTIDPKEPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRTHRPSYEDRVCFVATVRLATPQFIKEMCTVE
EPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYH
QWNSRPEFIVCTHTVVSYAEVRAERRRELGIEESLPETAADKKRVVEQLRKNLIVKQEQPDKFQIQPLPQSENKLQTAQQQPLQQLQQQQ
QYHHHHAQQSAAASPNLTASQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNLQTSSKVTGP
GAEAVQIVAKNTVTLQVQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKFTPTTLPTSQ
NSIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLAGPQTVQLSKPSLEKQTVKSHTETDEKQTESRTITPPAAPKPKREENPQKLAF
MVSLGLVTHDHLEEIQSKRQERKRRTTANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRGRPPKYNAVLGFGALTPTSPQSSHPDSPEN
EKTETTFTFPAPVQPVSLPSPTSTDGDIHEDFCSVCRKSGQLLMCDTCSRVYHLDCLDPPLKTIPKGMWICPRCQDQMLKKEEAIPWPGT
LAIVHSYIAYKAAKEEEKQKLLKWSSDLKQEREQLEQKVKQLSNSISKCMEMKNTILARQKEMHSSLEKVKQLIRLIHGIDLSKPVDSEA

--------------------------------------------------------------
>17273_17273_2_CLOCK-PHF21A_CLOCK_chr4_56319221_ENST00000309964_PHF21A_chr11_46001517_ENST00000323180_length(transcript)=4611nt_BP=1457nt
AGCTGATTCTATCACATTGTAAGATGCCTTTGGATAATTCTACAGTCCTCTTAAATGAATCTTTAGAACTTGGCAAGTCTCACTAGATAC
CTTCAATCATCATTTTGAGCTCAAAGAATTCTGAGACTTATGGTTGGTCATATAGAAGAGTACCTTGAACCTATAGTTTCCTGAAGAATC
AGTTTAAAAGATCCAAGGAGTACAAAAGGAGAAGTACAAATGTCTACTACAAGACGAAAACGTAGTATGTTATGTTGTTTACCGTAAGCT
GTAGTAAAATGAGCTCGATTGTTGACAGAGATGACAGTAGTATTTTTGATGGGTTGGTGGAAGAAGATGACAAGGACAAAGCGAAAAGAG
TATCTAGAAACAAATCTGAAAAGAAACGTAGAGATCAATTTAATGTTCTCATTAAAGAACTGGGATCCATGCTTCCTGGTAATGCTAGAA
AGATGGACAAATCTACTGTTCTGCAGAAAAGCATTGATTTTTTACGAAAACATAAAGAAATCACTGCACAGTCAGATGCTAGTGAAATTC
GACAGGACTGGAAACCTACATTCCTTAGTAATGAAGAGTTTACACAATTAATGTTAGAGGCTCTTGATGGTTTTTTTTTAGCAATCATGA
CAGATGGAAGCATAATATATGTGTCTGAGAGTGTAACTTCATTACTTGAACATTTACCATCTGATCTTGTGGATCAAAGTATATTTAATT
TTATCCCAGAAGGGGAACATTCAGAGGTTTATAAAATACTCTCTACTCATCTGCTGGAAAGTGATTCATTAACCCCAGAATATTTAAAAT
CAAAAAATCAGTTAGAATTCTGTTGTCACATGCTGCGAGGAACAATAGACCCAAAGGAGCCATCTACCTATGAATATGTAAAATTTATAG
GAAATTTCAAATCTTTAAACAGTGTATCCTCTTCAGCACACAATGGTTTTGAAGGAACTATACAACGCACACATAGGCCATCTTATGAAG
ATAGAGTTTGTTTTGTAGCTACTGTCAGGTTAGCTACACCTCAGTTCATCAAGGAAATGTGCACTGTTGAAGAACCCAATGAAGAGTTTA
CATCTAGACATAGTTTAGAATGGAAGTTTCTGTTTCTAGATCACAGGGCACCACCCATAATAGGGTATTTGCCATTTGAAGTTCTGGGAA
CATCAGGCTATGATTACTATCATGTGGATGACCTAGAAAATTTGGCAAAATGTCATGAGCACTTAATGCAATATGGGAAAGGCAAATCAT
GTTATTATAGGTTCCTGACTAAGGGGCAACAGTGGATTTGGCTTCAGACTCATTATTATATCACTTACCATCAGTGGAATTCAAGGCCAG
AGTTTATTGTTTGTACTCACACTGTAGTAAGTTATGCAGAAGTTAGGGCTGAAAGACGACGAGAACTTGGCATTGAAGAGTCTCTTCCTG
AGACAGCTGCTGACAAAAAAAGAGTAGTTGAACAGCTACGGAAGAACCTGATAGTAAAGCAAGAACAACCGGACAAGTTCCAAATACAGC
CATTGCCACAATCTGAAAACAAACTACAAACAGCACAGCAGCAACCACTACAGCAACTACAACAACAGCAGCAGTACCACCACCACCACG
CCCAGCAGTCAGCTGCAGCCTCTCCCAACCTGACTGCTTCACAGAAGACTGTAACTACAGCTTCTATGATTACCACAAAGACACTACCTC
TCGTCTTGAAAGCAGCAACTGCGACCATGCCTGCCTCTGTGGTGGGCCAGAGACCTACCATTGCTATGGTGACCGCCATCAACAGTCAGA
AGGCTGTGCTCAGCACTGATGTGCAGAACACACCAGTCAACCTCCAGACGTCTAGTAAGGTCACTGGGCCTGGGGCAGAGGCTGTCCAAA
TTGTGGCAAAAAACACAGTCACTCTGCAGGTTCAGGCAACACCTCCTCAGCCCATCAAAGTACCACAGTTTATCCCCCCTCCTAGACTCA
CTCCACGTCCAAACTTTCTTCCACAGGTTCGACCCAAGCCTGTGGCCCAGAATAACATTCCTATTGCCCCAGCACCACCTCCCATGCTCG
CAGCTCCTCAGCTTATCCAGAGGCCCGTCATGCTGACCAAGTTCACCCCCACAACCCTTCCCACATCCCAGAATTCCATCCACCCCGTCC
GTGTCGTCAATGGGCAGACTGCAACCATAGCCAAAACGTTCCCCATGGCCCAGCTCACCAGCATTGTGATAGCTACTCCAGGGACCAGAC
TCGCTGGACCTCAAACTGTACAGCTTAGCAAGCCAAGTCTTGAAAAACAGACAGTTAAATCTCACACAGAAACAGATGAGAAACAAACAG
AGAGCCGCACCATCACCCCACCTGCTGCACCCAAACCAAAACGGGAGGAGAACCCTCAGAAACTTGCCTTCATGGTGTCTCTAGGGTTGG
TAACACATGACCATCTAGAAGAAATCCAAAGCAAGAGGCAAGAGCGAAAAAGAAGAACAACAGCAAATCCGGTCTACAGTGGAGCAGTCT
TTGAGCCAGAGCGTAAGAAGAGTGCAGTGACATACCTAAACAGCACAATGCACCCTGGGACCCGGAAGAGAGCCAATGAGGAACACTGGC
CAAAGGGTGATATTCATGAGGATTTTTGCAGCGTTTGCAGAAAAAGTGGCCAGTTACTGATGTGCGACACATGTTCCCGTGTATATCATT
TGGACTGCTTAGACCCCCCTCTGAAAACAATTCCCAAGGGCATGTGGATCTGTCCCAGATGTCAGGACCAGATGCTGAAGAAGGAAGAAG
CAATTCCATGGCCTGGAACTTTAGCAATTGTTCATTCCTATATTGCCTACAAAGCAGCAAAAGAAGAAGAGAAACAGAAGTTACTTAAAT
GGAGTTCAGATTTAAAACAAGAACGAGAACAACTAGAGCAAAAGGTGAAACAGCTCAGCAATTCCATAAGTAAATGCATGGAAATGAAGA
ACACCATCCTGGCCCGGCAGAAGGAGATGCACAGCTCCCTGGAGAAGGTAAAACAGCTGATTCGCCTCATCCACGGCATCGACCTCTCCA
AACCTGTAGACTCTGAGGCCACTGTGGGGGCCATCTCCAATGGCCCGGACTGCACCCCCCCTGCCAATGCCGCCACCTCCACGCCGGCCC
CTTCCCCCTCCTCCCAGAGCTGCACAGCGAACTGTAACCAGGGGGAAGAGACTAAATAACAGAGCCCCTCTAGGAGAAGCCACGGGATCC
CGGCGGCAAGGAGAACAGAACACTGAAGACTCTAGAAAAGCAAAGCCGGATTTCTGGAAAGTGCAGAATTCTTTTGGTTCTTTGGTTCCA
GAGAGAGAGAAGATGCTTGTGCCAGGTGGCACCAGAGTTTGCCAATTGATCCTTCTTATTCTGTGTGTACATGCAAAGATTGGACCATGT
TACATGAAATAGTGCCAGCTGGAGGTTCTTTGCCAGCACCATGCCAAGTGAAATAATATATTTACTCTCTCTATTATACACCAGTGTGTG
CCTGCAGCAGCCTCCACAGCCACGATGGGTTTGTTTCTGTTTTCTTGGGTGGGGAGCAGGGACGGGCGGAGGGAGGAGAGCAGGTTTCAG
ATCCTTACTTGCCGAGCCGTTTGTTTAGGTAGAGAAGACAAGTCCAAAGAGTGTGTGGGCTTTCCTGTTTCTAAACTTTCGCTACTATAA
AACCAAAAAAAGGAATTGAGATTTCACCAACCCCAGTGCCCAGAAGAGGGAAGGGGAGTGGCTGGAGGGAGCAGGGGGTGGGACAGTGTA
TCAAATAAGCAGTATTTAATCACCTCTGGCGGGGGCCTCGTGCAAGGGGAGACTGACACCAAGAACAGCCAGTAGGTTCTTCTCCCCTGC
ACTCTGCTCCCTGCGCGGTAACCCCACCACTCCTGAAGCCTGCCCAGTCTCCTTCCTTCCCTGCTTGGTGAGTCGCGCATCTCCGTGGTT
ATCCCGCTGTCTCCTCTCCAAGAACAAGCAGAGCCCGGGCCACTGGCCCTTGCCCAAGGCAGGGAAGAAGGATGTGTGTGTCCAGGAAGG
AAAAAAAGGTGGATCAGTGATTTTACTTGAAAACAAGCTCCATCCCTTTTCTATATTTATAAGAAGAGAAGATCTTGAGTGAAGCAGCAC
GCGACCCAGGTGTGTGTGAATTGAATGGAGACGTTTCTTTTCTCTTTCTTTAATTTTTGTTTTTGTTCTTTTTTTCTTTAAGGAAAGTTT
TATTTTACTGTTCATTTTACTTTCTTGGTAACAAAAACTAAAATAAGGAATAGAAAAGCTGTTTTTCAGGCTGACAGTCCAATTAAGGGT
AGCCAAGACCTTGCATGGTAGAGTAGGAATCATAGTGTCAGTGAGGTCCCGTGAGTCTTTGTGAGTCCTTGTGTCATCGTTCGGGCACTG
TTTTTTTATGCAAGGGCAAAAATCTTTGTATCTGGGGAAAAAAAACTTTTTTTTAAATTAAAAAGGAAAATAAAAGATATTGAGGTCTTC
CTAGTGTTACTTAAATTAAGATCAAGGTAAGAAACATTGTAAAAAAAAATTACAAAAGTGCTATTTGTTTCCTAAAAACAGTGATTTCTA

>17273_17273_2_CLOCK-PHF21A_CLOCK_chr4_56319221_ENST00000309964_PHF21A_chr11_46001517_ENST00000323180_length(amino acids)=985AA_BP=402
MLFTVSCSKMSSIVDRDDSSIFDGLVEEDDKDKAKRVSRNKSEKKRRDQFNVLIKELGSMLPGNARKMDKSTVLQKSIDFLRKHKEITAQ
SDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSL
TPEYLKSKNQLEFCCHMLRGTIDPKEPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRTHRPSYEDRVCFVATVRLATPQFIKEMCTVE
EPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYH
QWNSRPEFIVCTHTVVSYAEVRAERRRELGIEESLPETAADKKRVVEQLRKNLIVKQEQPDKFQIQPLPQSENKLQTAQQQPLQQLQQQQ
QYHHHHAQQSAAASPNLTASQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNLQTSSKVTGP
GAEAVQIVAKNTVTLQVQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKFTPTTLPTSQ
NSIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLAGPQTVQLSKPSLEKQTVKSHTETDEKQTESRTITPPAAPKPKREENPQKLAF
MVSLGLVTHDHLEEIQSKRQERKRRTTANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRANEEHWPKGDIHEDFCSVCRKSGQLLMCDT
CSRVYHLDCLDPPLKTIPKGMWICPRCQDQMLKKEEAIPWPGTLAIVHSYIAYKAAKEEEKQKLLKWSSDLKQEREQLEQKVKQLSNSIS

--------------------------------------------------------------
>17273_17273_3_CLOCK-PHF21A_CLOCK_chr4_56319221_ENST00000309964_PHF21A_chr11_46001517_ENST00000418153_length(transcript)=3834nt_BP=1457nt
AGCTGATTCTATCACATTGTAAGATGCCTTTGGATAATTCTACAGTCCTCTTAAATGAATCTTTAGAACTTGGCAAGTCTCACTAGATAC
CTTCAATCATCATTTTGAGCTCAAAGAATTCTGAGACTTATGGTTGGTCATATAGAAGAGTACCTTGAACCTATAGTTTCCTGAAGAATC
AGTTTAAAAGATCCAAGGAGTACAAAAGGAGAAGTACAAATGTCTACTACAAGACGAAAACGTAGTATGTTATGTTGTTTACCGTAAGCT
GTAGTAAAATGAGCTCGATTGTTGACAGAGATGACAGTAGTATTTTTGATGGGTTGGTGGAAGAAGATGACAAGGACAAAGCGAAAAGAG
TATCTAGAAACAAATCTGAAAAGAAACGTAGAGATCAATTTAATGTTCTCATTAAAGAACTGGGATCCATGCTTCCTGGTAATGCTAGAA
AGATGGACAAATCTACTGTTCTGCAGAAAAGCATTGATTTTTTACGAAAACATAAAGAAATCACTGCACAGTCAGATGCTAGTGAAATTC
GACAGGACTGGAAACCTACATTCCTTAGTAATGAAGAGTTTACACAATTAATGTTAGAGGCTCTTGATGGTTTTTTTTTAGCAATCATGA
CAGATGGAAGCATAATATATGTGTCTGAGAGTGTAACTTCATTACTTGAACATTTACCATCTGATCTTGTGGATCAAAGTATATTTAATT
TTATCCCAGAAGGGGAACATTCAGAGGTTTATAAAATACTCTCTACTCATCTGCTGGAAAGTGATTCATTAACCCCAGAATATTTAAAAT
CAAAAAATCAGTTAGAATTCTGTTGTCACATGCTGCGAGGAACAATAGACCCAAAGGAGCCATCTACCTATGAATATGTAAAATTTATAG
GAAATTTCAAATCTTTAAACAGTGTATCCTCTTCAGCACACAATGGTTTTGAAGGAACTATACAACGCACACATAGGCCATCTTATGAAG
ATAGAGTTTGTTTTGTAGCTACTGTCAGGTTAGCTACACCTCAGTTCATCAAGGAAATGTGCACTGTTGAAGAACCCAATGAAGAGTTTA
CATCTAGACATAGTTTAGAATGGAAGTTTCTGTTTCTAGATCACAGGGCACCACCCATAATAGGGTATTTGCCATTTGAAGTTCTGGGAA
CATCAGGCTATGATTACTATCATGTGGATGACCTAGAAAATTTGGCAAAATGTCATGAGCACTTAATGCAATATGGGAAAGGCAAATCAT
GTTATTATAGGTTCCTGACTAAGGGGCAACAGTGGATTTGGCTTCAGACTCATTATTATATCACTTACCATCAGTGGAATTCAAGGCCAG
AGTTTATTGTTTGTACTCACACTGTAGTAAGTTATGCAGAAGTTAGGGCTGAAAGACGACGAGAACTTGGCATTGAAGAGTCTCTTCCTG
AGACAGCTGCTGACAAAAAAAGAGTAGTTGAACAGCTACGGAAGAACCTGATAGTAAAGCAAGAACAACCGGACAAGTTCCAAATACAGC
CATTGCCACAATCTGAAAACAAACTACAAACAGCACAGCAGCAACCACTACAGCAACTACAACAACAGCAGCAGTACCACCACCACCACG
CCCAGCAGTCAGCTGCAGCCTCTCCCAACCTGACTGCTTCACAGAAGACTGTAACTACAGCTTCTATGATTACCACAAAGACACTACCTC
TCGTCTTGAAAGCAGCAACTGCGACCATGCCTGCCTCTGTGGTGGGCCAGAGACCTACCATTGCTATGGTGACCGCCATCAACAGTCAGA
AGGCTGTGCTCAGCACTGATGTGCAGAACACACCAGTCAACCTCCAGACGTCTAGTAAGGTCACTGGGCCTGGGGCAGAGGCTGTCCAAA
TTGTGGCAAAAAACACAGTCACTCTGGTTCAGGCAACACCTCCTCAGCCCATCAAAGTACCACAGTTTATCCCCCCTCCTAGACTCACTC
CACGTCCAAACTTTCTTCCACAGGTTCGACCCAAGCCTGTGGCCCAGAATAACATTCCTATTGCCCCAGCACCACCTCCCATGCTCGCAG
CTCCTCAGCTTATCCAGAGGCCCGTCATGCTGACCAAGTTCACCCCCACAACCCTTCCCACATCCCAGAATTCCATCCACCCCGTCCGTG
TCGTCAATGGGCAGACTGCAACCATAGCCAAAACGTTCCCCATGGCCCAGCTCACCAGCATTGTGATAGCTACTCCAGGGACCAGACTCG
CTGGACCTCAAACTGTACAGCTTAGCAAGCCAAGTCTTGAAAAACAGACAGTTAAATCTCACACAGAAACAGATGAGAAACAAACAGAGA
GCCGCACCATCACCCCACCTGCTGCACCCAAACCAAAACGGGAGGAGAACCCTCAGAAACTTGCCTTCATGGTGTCTCTAGGGTTGGTAA
CACATGACCATCTAGAAGAAATCCAAAGCAAGAGGCAAGAGCGAAAAAGAAGAACAACAGCAAATCCGGTCTACAGTGGAGCAGTCTTTG
AGCCAGAGCGTAAGAAGAGTGCAGTGACATACCTAAACAGCACAATGCACCCTGGGACCCGGAAGAGAGGTCGTCCTCCAAAATACAATG
CAGTGCTGGGGTTTGGAGCCCTTACCCCAACATCCCCCCAATCCAGTCATCCTGACTCCCCTGAAAATGAAAAGACAGAGACCACATTCA
CTTTCCCTGCACCTGTTCAGCCTGTGTCCCTGCCCAGCCCCACCTCCACAGACGGTGATATTCATGAGGATTTTTGCAGCGTTTGCAGAA
AAAGTGGCCAGTTACTGATGTGCGACACATGTTCCCGTGTATATCATTTGGACTGCTTAGACCCCCCTCTGAAAACAATTCCCAAGGGCA
TGTGGATCTGTCCCAGATGTCAGGACCAGATGCTGAAGAAGGAAGAAGCAATTCCATGGCCTGGAACTTTAGCAATTGTTCATTCCTATA
TTGCCTACAAAGCAGCAAAAGAAGAAGAGAAACAGAAGTTACTTAAATGGAGTTCAGATTTAAAACAAGAACGAGAACAACTAGAGCAAA
AGGTGAAACAGCTCAGCAATTCCATAAGTAAATGCATGGAAATGAAGAACACCATCCTGGCCCGGCAGAAGGAGATGCACAGCTCCCTGG
AGAAGGTAAAACAGCTGATTCGCCTCATCCACGGCATCGACCTCTCCAAACCTGTAGACTCTGAGGCCACTGTGGGGGCCATCTCCAATG
GCCCGGACTGCACCCCCCCTGCCAATGCCGCCACCTCCACGCCGGCCCCTTCCCCCTCCTCCCAGAGCTGCACAGCGAACTGTAACCAGG
GGGAAGAGACTAAATAACAGAGCCCCTCTAGGAGAAGCCACGGGATCCCGGCGGCAAGGAGAACAGAACACTGAAGACTCTAGAAAAGCA
AAGCCGGATTTCTGGAAAGTGCAGAATTCTTTTGGTTCTTTGGTTCCAGAGAGAGAGAAGATGCTTGTGCCAGGTGGCACCAGAGTTTGC
CAATTGATCCTTCTTATTCTGTGTGTACATGCAAAGATTGGACCATGTTACATGAAATAGTGCCAGCTGGAGGTTCTTTGCCAGCACCAT
GCCAAGTGAAATAATATATTTACTCTCTCTATTATACACCAGTGTGTGCCTGCAGCAGCCTCCACAGCCACGATGGGTTTGTTTCTGTTT
TCTTGGGTGGGGAGCAGGGACGGGCGGAGGGAGGAGAGCAGGTTTCAGATCCTTACTTGCCGAGCCGTTTGTTTAGGTAGAGAAGACAAG

>17273_17273_3_CLOCK-PHF21A_CLOCK_chr4_56319221_ENST00000309964_PHF21A_chr11_46001517_ENST00000418153_length(amino acids)=1031AA_BP=402
MLFTVSCSKMSSIVDRDDSSIFDGLVEEDDKDKAKRVSRNKSEKKRRDQFNVLIKELGSMLPGNARKMDKSTVLQKSIDFLRKHKEITAQ
SDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSL
TPEYLKSKNQLEFCCHMLRGTIDPKEPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRTHRPSYEDRVCFVATVRLATPQFIKEMCTVE
EPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYH
QWNSRPEFIVCTHTVVSYAEVRAERRRELGIEESLPETAADKKRVVEQLRKNLIVKQEQPDKFQIQPLPQSENKLQTAQQQPLQQLQQQQ
QYHHHHAQQSAAASPNLTASQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNLQTSSKVTGP
GAEAVQIVAKNTVTLVQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKFTPTTLPTSQN
SIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLAGPQTVQLSKPSLEKQTVKSHTETDEKQTESRTITPPAAPKPKREENPQKLAFM
VSLGLVTHDHLEEIQSKRQERKRRTTANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRGRPPKYNAVLGFGALTPTSPQSSHPDSPENE
KTETTFTFPAPVQPVSLPSPTSTDGDIHEDFCSVCRKSGQLLMCDTCSRVYHLDCLDPPLKTIPKGMWICPRCQDQMLKKEEAIPWPGTL
AIVHSYIAYKAAKEEEKQKLLKWSSDLKQEREQLEQKVKQLSNSISKCMEMKNTILARQKEMHSSLEKVKQLIRLIHGIDLSKPVDSEAT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CLOCK-PHF21A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	CLOCK	chr4:56319221	chr11:46001517	ENST00000309964	-	14	22	371_845	402.0	847.0	NR3C1
Hgene	CLOCK	chr4:56319221	chr11:46001517	ENST00000381322	-	16	24	371_845	402.0	847.0	NR3C1
Hgene	CLOCK	chr4:56319221	chr11:46001517	ENST00000513440	-	15	23	371_845	402.0	847.0	NR3C1
Hgene	CLOCK	chr4:56319221	chr11:46001517	ENST00000309964	-	14	22	450_570	402.0	847.0	SIRT1
Hgene	CLOCK	chr4:56319221	chr11:46001517	ENST00000381322	-	16	24	450_570	402.0	847.0	SIRT1
Hgene	CLOCK	chr4:56319221	chr11:46001517	ENST00000513440	-	15	23	450_570	402.0	847.0	SIRT1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CLOCK-PHF21A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CLOCK-PHF21A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CLOCK	C0005586	Bipolar Disorder	5	PSYGENET
Hgene	CLOCK	C0011570	Mental Depression	5	PSYGENET
Hgene	CLOCK	C0011581	Depressive disorder	5	PSYGENET
Hgene	CLOCK	C0041696	Unipolar Depression	5	PSYGENET
Hgene	CLOCK	C0525045	Mood Disorders	5	PSYGENET
Hgene	CLOCK	C1269683	Major Depressive Disorder	5	PSYGENET
Hgene	CLOCK	C0085159	Seasonal Affective Disorder	3	PSYGENET
Hgene	CLOCK	C3496069	cocaine use	2	PSYGENET
Hgene	CLOCK	C0001957	Alcohol Withdrawal Delirium	1	PSYGENET
Hgene	CLOCK	C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET
Hgene	CLOCK	C0036341	Schizophrenia	1	PSYGENET
Hgene	CLOCK	C0600427	Cocaine Dependence	1	PSYGENET
Tgene		C1832588	Chromosome 11p11.2 Deletion Syndrome	2	GENOMICS_ENGLAND;ORPHANET
Tgene		C0036421	Systemic Scleroderma	1	GENOMICS_ENGLAND
Tgene		C1849193	PEELING SKIN SYNDROME	1	GENOMICS_ENGLAND
Tgene		C3714756	Intellectual Disability	1	GENOMICS_ENGLAND
Tgene		C4721610	Carcinoma, Ovarian Epithelial	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:CLOCK-PHF21A (FusionGDB2 ID:HG9575TG51317)

Fusion Gene Summary for CLOCK-PHF21A

Fusion Gene ORF analysis for CLOCK-PHF21A

Fusion Genomic Features for CLOCK-PHF21A

Fusion Protein Features for CLOCK-PHF21A

Fusion Gene Sequence for CLOCK-PHF21A

Fusion Gene PPI Analysis for CLOCK-PHF21A

Related Drugs for CLOCK-PHF21A

Related Diseases for CLOCK-PHF21A

Fusion Gene Studies
in Kim Lab