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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:BRE-GPN1 (FusionGDB2 ID:HG9577TG11321)

Fusion Gene Summary for BRE-GPN1

Fusion gene summary

Fusion gene information	Fusion gene name: BRE-GPN1
	Fusion gene ID: hg9577tg11321
		Hgene	Tgene
	Gene symbol	BRE	GPN1
	Gene ID	9577	11321
	Gene name	BRISC and BRCA1 A complex member 2	GPN-loop GTPase 1
	Synonyms	BRCC4\|BRCC45\|BRE	ATPBD1A\|MBDIN\|NTPBP\|RPAP4\|XAB1
	Cytomap	('BRE')('GPN1') 2p23.2	2p23.3
	Type of gene	protein-coding	protein-coding
	Description	BRISC and BRCA1-A complex member 2BRCA1-A complex subunit BREBRCA1/BRCA2-containing complex subunit 45BRCA1/BRCA2-containing complex, subunit 4brain and reproductive organ-expressed (TNFRSF1A modulator)brain and reproductive organ-expressed protein	GPN-loop GTPase 1ATP(GTP)-binding proteinMBD2-interacting proteinRNA polymerase II associated protein 4RNAPII-associated protein 4XPA binding protein 1, GTPase
	Modification date	20200313	20200328
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000603461, ENST00000342045, ENST00000344773, ENST00000361704, ENST00000379624, ENST00000379632,
Fusion gene scores	* DoF score	13 X 9 X 8=936	7 X 8 X 7=392
	# samples	15	11
	** MAII score	log2(15/936*10)=-2.64154602908752 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/392*10)=-1.83335013059055 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: BRE [Title/Abstract] AND GPN1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	BRE(28152775)-GPN1(27872982), # samples:2 BRE(28117551)-GPN1(27870703), # samples:2
Anticipated loss of major functional domain due to fusion event.	BRE-GPN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BRE-GPN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BRE-GPN1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. BRE-GPN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. BRE-GPN1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	BRE	GO:0043066	negative regulation of apoptotic process	15465831

Fusion gene breakpoints across BRE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GPN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-VQ-A91K-01A	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
ChimerDB4	STAD	TCGA-VQ-A91K	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
ChimerDB4	UCEC	TCGA-B5-A0JN-01A	BRE	chr2	28152775	-	GPN1	chr2	27872982	+
ChimerDB4	UCEC	TCGA-B5-A0JN-01A	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
ChimerDB4	UCS	TCGA-N9-A4Q1-01A	BRE	chr2	28117551	-	GPN1	chr2	27870703	+
ChimerDB4	UCS	TCGA-N9-A4Q1	BRE	chr2	28117551	+	GPN1	chr2	27870703	+

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Fusion Gene ORF analysis for BRE-GPN1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000603461	ENST00000264718	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
3UTR-3CDS	ENST00000603461	ENST00000407583	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
3UTR-3CDS	ENST00000603461	ENST00000424214	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
3UTR-3CDS	ENST00000603461	ENST00000458167	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
3UTR-3CDS	ENST00000603461	ENST00000503738	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
3UTR-3CDS	ENST00000603461	ENST00000515877	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
3UTR-3CDS	ENST00000603461	ENST00000610189	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
3UTR-3UTR	ENST00000603461	ENST00000461249	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
3UTR-3UTR	ENST00000603461	ENST00000461249	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
3UTR-5UTR	ENST00000603461	ENST00000264718	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
3UTR-5UTR	ENST00000603461	ENST00000264718	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
3UTR-5UTR	ENST00000603461	ENST00000407583	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
3UTR-5UTR	ENST00000603461	ENST00000407583	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
3UTR-5UTR	ENST00000603461	ENST00000424214	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
3UTR-5UTR	ENST00000603461	ENST00000424214	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
3UTR-5UTR	ENST00000603461	ENST00000458167	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
3UTR-5UTR	ENST00000603461	ENST00000458167	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
3UTR-5UTR	ENST00000603461	ENST00000610189	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
3UTR-5UTR	ENST00000603461	ENST00000610189	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
3UTR-intron	ENST00000603461	ENST00000461249	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
3UTR-intron	ENST00000603461	ENST00000503738	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
3UTR-intron	ENST00000603461	ENST00000503738	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
3UTR-intron	ENST00000603461	ENST00000515877	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
3UTR-intron	ENST00000603461	ENST00000515877	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-3UTR	ENST00000342045	ENST00000461249	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-3UTR	ENST00000342045	ENST00000461249	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-3UTR	ENST00000342045	ENST00000461249	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
5CDS-3UTR	ENST00000344773	ENST00000461249	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-3UTR	ENST00000344773	ENST00000461249	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-3UTR	ENST00000344773	ENST00000461249	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
5CDS-3UTR	ENST00000361704	ENST00000461249	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-3UTR	ENST00000361704	ENST00000461249	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-3UTR	ENST00000361704	ENST00000461249	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
5CDS-3UTR	ENST00000379624	ENST00000461249	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-3UTR	ENST00000379624	ENST00000461249	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-3UTR	ENST00000379624	ENST00000461249	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
5CDS-3UTR	ENST00000379632	ENST00000461249	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-3UTR	ENST00000379632	ENST00000461249	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-3UTR	ENST00000379632	ENST00000461249	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
5CDS-5UTR	ENST00000342045	ENST00000264718	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000342045	ENST00000264718	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000342045	ENST00000407583	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000342045	ENST00000407583	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000342045	ENST00000424214	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000342045	ENST00000424214	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000342045	ENST00000458167	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000342045	ENST00000458167	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000342045	ENST00000610189	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000342045	ENST00000610189	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000344773	ENST00000264718	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000344773	ENST00000264718	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000344773	ENST00000407583	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000344773	ENST00000407583	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000344773	ENST00000424214	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000344773	ENST00000424214	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000344773	ENST00000458167	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000344773	ENST00000458167	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000344773	ENST00000610189	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000344773	ENST00000610189	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000361704	ENST00000264718	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000361704	ENST00000264718	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000361704	ENST00000407583	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000361704	ENST00000407583	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000361704	ENST00000424214	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000361704	ENST00000424214	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000361704	ENST00000458167	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000361704	ENST00000458167	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000361704	ENST00000610189	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000361704	ENST00000610189	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000379624	ENST00000264718	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000379624	ENST00000264718	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000379624	ENST00000407583	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000379624	ENST00000407583	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000379624	ENST00000424214	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000379624	ENST00000424214	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000379624	ENST00000458167	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000379624	ENST00000458167	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000379624	ENST00000610189	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000379624	ENST00000610189	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000379632	ENST00000264718	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000379632	ENST00000264718	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000379632	ENST00000407583	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000379632	ENST00000407583	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000379632	ENST00000424214	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000379632	ENST00000424214	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000379632	ENST00000458167	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000379632	ENST00000458167	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-5UTR	ENST00000379632	ENST00000610189	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000379632	ENST00000610189	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-intron	ENST00000342045	ENST00000461249	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
5CDS-intron	ENST00000342045	ENST00000503738	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-intron	ENST00000342045	ENST00000503738	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-intron	ENST00000342045	ENST00000515877	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-intron	ENST00000342045	ENST00000515877	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-intron	ENST00000344773	ENST00000461249	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
5CDS-intron	ENST00000344773	ENST00000503738	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-intron	ENST00000344773	ENST00000503738	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-intron	ENST00000344773	ENST00000515877	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-intron	ENST00000344773	ENST00000515877	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-intron	ENST00000361704	ENST00000461249	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
5CDS-intron	ENST00000361704	ENST00000503738	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-intron	ENST00000361704	ENST00000503738	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-intron	ENST00000361704	ENST00000515877	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-intron	ENST00000361704	ENST00000515877	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-intron	ENST00000379624	ENST00000461249	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
5CDS-intron	ENST00000379624	ENST00000503738	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-intron	ENST00000379624	ENST00000503738	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-intron	ENST00000379624	ENST00000515877	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-intron	ENST00000379624	ENST00000515877	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-intron	ENST00000379632	ENST00000461249	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
5CDS-intron	ENST00000379632	ENST00000503738	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-intron	ENST00000379632	ENST00000503738	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
5CDS-intron	ENST00000379632	ENST00000515877	BRE	chr2	28152775	+	GPN1	chr2	27852726	+
5CDS-intron	ENST00000379632	ENST00000515877	BRE	chr2	28152775	+	GPN1	chr2	27852725	+
Frame-shift	ENST00000342045	ENST00000264718	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000342045	ENST00000264718	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000342045	ENST00000407583	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000342045	ENST00000407583	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000342045	ENST00000424214	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000342045	ENST00000458167	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000342045	ENST00000503738	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000342045	ENST00000503738	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000342045	ENST00000515877	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000342045	ENST00000515877	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000342045	ENST00000610189	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000342045	ENST00000610189	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000344773	ENST00000264718	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000344773	ENST00000264718	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000344773	ENST00000407583	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000344773	ENST00000407583	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000344773	ENST00000424214	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000344773	ENST00000458167	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000344773	ENST00000503738	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000344773	ENST00000503738	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000344773	ENST00000515877	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000344773	ENST00000515877	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000344773	ENST00000610189	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000344773	ENST00000610189	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000361704	ENST00000264718	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000361704	ENST00000264718	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000361704	ENST00000407583	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000361704	ENST00000407583	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000361704	ENST00000424214	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000361704	ENST00000458167	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000361704	ENST00000503738	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000361704	ENST00000503738	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000361704	ENST00000515877	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000361704	ENST00000515877	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000361704	ENST00000610189	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000361704	ENST00000610189	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000379624	ENST00000264718	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000379624	ENST00000264718	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000379624	ENST00000407583	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000379624	ENST00000407583	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000379624	ENST00000424214	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000379624	ENST00000458167	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000379624	ENST00000503738	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000379624	ENST00000503738	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000379624	ENST00000515877	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000379624	ENST00000515877	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000379624	ENST00000610189	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000379624	ENST00000610189	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000379632	ENST00000264718	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000379632	ENST00000264718	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000379632	ENST00000407583	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000379632	ENST00000407583	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000379632	ENST00000424214	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000379632	ENST00000458167	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000379632	ENST00000503738	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000379632	ENST00000503738	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000379632	ENST00000515877	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000379632	ENST00000515877	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
Frame-shift	ENST00000379632	ENST00000610189	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
Frame-shift	ENST00000379632	ENST00000610189	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
In-frame	ENST00000342045	ENST00000424214	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
In-frame	ENST00000342045	ENST00000458167	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
In-frame	ENST00000344773	ENST00000424214	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
In-frame	ENST00000344773	ENST00000458167	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
In-frame	ENST00000361704	ENST00000424214	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
In-frame	ENST00000361704	ENST00000458167	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
In-frame	ENST00000379624	ENST00000424214	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
In-frame	ENST00000379624	ENST00000458167	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
In-frame	ENST00000379632	ENST00000424214	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
In-frame	ENST00000379632	ENST00000458167	BRE	chr2	28152775	+	GPN1	chr2	27872982	+
intron-3CDS	ENST00000603461	ENST00000264718	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000603461	ENST00000407583	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000603461	ENST00000424214	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000603461	ENST00000458167	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000603461	ENST00000503738	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000603461	ENST00000515877	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000603461	ENST00000610189	BRE	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3UTR	ENST00000603461	ENST00000461249	BRE	chr2	28117551	+	GPN1	chr2	27870703	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000344773	BRE	chr2	28152775	+	ENST00000458167	GPN1	chr2	27872982	+	1073	343	421	128	97
ENST00000344773	BRE	chr2	28152775	+	ENST00000424214	GPN1	chr2	27872982	+	1073	343	421	128	97
ENST00000379624	BRE	chr2	28152775	+	ENST00000458167	GPN1	chr2	27872982	+	1052	322	400	107	97
ENST00000379624	BRE	chr2	28152775	+	ENST00000424214	GPN1	chr2	27872982	+	1052	322	400	107	97
ENST00000342045	BRE	chr2	28152775	+	ENST00000458167	GPN1	chr2	27872982	+	1076	346	424	131	97
ENST00000342045	BRE	chr2	28152775	+	ENST00000424214	GPN1	chr2	27872982	+	1076	346	424	131	97
ENST00000379632	BRE	chr2	28152775	+	ENST00000458167	GPN1	chr2	27872982	+	1075	345	423	130	97
ENST00000379632	BRE	chr2	28152775	+	ENST00000424214	GPN1	chr2	27872982	+	1075	345	423	130	97
ENST00000361704	BRE	chr2	28152775	+	ENST00000458167	GPN1	chr2	27872982	+	1009	279	357	64	97
ENST00000361704	BRE	chr2	28152775	+	ENST00000424214	GPN1	chr2	27872982	+	1009	279	357	64	97

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000344773	ENST00000458167	BRE	chr2	28152775	+	GPN1	chr2	27872982	+	0.049454313	0.9505457
ENST00000344773	ENST00000424214	BRE	chr2	28152775	+	GPN1	chr2	27872982	+	0.049454313	0.9505457
ENST00000379624	ENST00000458167	BRE	chr2	28152775	+	GPN1	chr2	27872982	+	0.088508256	0.91149175
ENST00000379624	ENST00000424214	BRE	chr2	28152775	+	GPN1	chr2	27872982	+	0.088508256	0.91149175
ENST00000342045	ENST00000458167	BRE	chr2	28152775	+	GPN1	chr2	27872982	+	0.062740944	0.937259
ENST00000342045	ENST00000424214	BRE	chr2	28152775	+	GPN1	chr2	27872982	+	0.062740944	0.937259
ENST00000379632	ENST00000458167	BRE	chr2	28152775	+	GPN1	chr2	27872982	+	0.05937789	0.9406221
ENST00000379632	ENST00000424214	BRE	chr2	28152775	+	GPN1	chr2	27872982	+	0.05937789	0.9406221
ENST00000361704	ENST00000458167	BRE	chr2	28152775	+	GPN1	chr2	27872982	+	0.072619766	0.92738026
ENST00000361704	ENST00000424214	BRE	chr2	28152775	+	GPN1	chr2	27872982	+	0.072619766	0.92738026

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Fusion Genomic Features for BRE-GPN1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
BRE	chr2	28117551	+	GPN1	chr2	27870702	+	0.000191027	0.99980897
BRE	chr2	28152775	+	GPN1	chr2	27852725	+	4.05E-07	0.99999964
BRE	chr2	28152775	+	GPN1	chr2	27852725	+	4.05E-07	0.99999964
BRE	chr2	28152775	+	GPN1	chr2	27872981	+	4.74E-10	1
BRE	chr2	28117551	+	GPN1	chr2	27870702	+	0.000191027	0.99980897
BRE	chr2	28152775	+	GPN1	chr2	27852725	+	4.05E-07	0.99999964
BRE	chr2	28152775	+	GPN1	chr2	27852725	+	4.05E-07	0.99999964
BRE	chr2	28152775	+	GPN1	chr2	27872981	+	4.74E-10	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BRE-GPN1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:28152775/chr2:27872982)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BRE

chr2:28152775

chr2:27872982

ENST00000342045

275_364

384.0

Region

Note=UEV-like 2

Hgene

BRE

chr2:28152775

chr2:27872982

ENST00000342045

30_147

384.0

Region

Note=UEV-like 1

Hgene

BRE

chr2:28152775

chr2:27872982

ENST00000344773

275_364

528.6666666666666

Region

Note=UEV-like 2

Hgene

BRE

chr2:28152775

chr2:27872982

ENST00000344773

30_147

528.6666666666666

Region

Note=UEV-like 1

Hgene

BRE

chr2:28152775

chr2:27872982

ENST00000361704

275_364

511.0

Region

Note=UEV-like 2

Hgene

BRE

chr2:28152775

chr2:27872982

ENST00000361704

30_147

511.0

Region

Note=UEV-like 1

Hgene

BRE

chr2:28152775

chr2:27872982

ENST00000379624

275_364

384.0

Region

Note=UEV-like 2

Hgene

BRE

chr2:28152775

chr2:27872982

ENST00000379624

30_147

384.0

Region

Note=UEV-like 1

Hgene

BRE

chr2:28152775

chr2:27872982

ENST00000379632

275_364

511.0

Region

Note=UEV-like 2

Hgene

BRE

chr2:28152775

chr2:27872982

ENST00000379632

30_147

511.0

Region

Note=UEV-like 1

Tgene

GPN1

chr2:28152775

chr2:27872982

ENST00000407583

86_88

334

363.0

Motif

Gly-Pro-Asn (GPN)-loop%3B involved in dimer interface

Tgene

GPN1

chr2:28152775

chr2:27872982

ENST00000424214

86_88

267

296.0

Motif

Gly-Pro-Asn (GPN)-loop%3B involved in dimer interface

Tgene

GPN1

chr2:28152775

chr2:27872982

ENST00000458167

86_88

251

280.0

Motif

Gly-Pro-Asn (GPN)-loop%3B involved in dimer interface

Tgene

GPN1

chr2:28152775

chr2:27872982

ENST00000503738

86_88

251

280.0

Motif

Gly-Pro-Asn (GPN)-loop%3B involved in dimer interface

Tgene

GPN1

chr2:28152775

chr2:27872982

ENST00000515877

86_88

267

296.0

Motif

Gly-Pro-Asn (GPN)-loop%3B involved in dimer interface

Tgene

GPN1

chr2:28152775

chr2:27872982

ENST00000407583

189_192

334

363.0

Nucleotide binding

GTP

Tgene

GPN1

chr2:28152775

chr2:27872982

ENST00000407583

29_34

334

363.0

Nucleotide binding

GTP

Tgene

GPN1

chr2:28152775

chr2:27872982

ENST00000424214

189_192

267

296.0

Nucleotide binding

GTP

Tgene

GPN1

chr2:28152775

chr2:27872982

ENST00000424214

29_34

267

296.0

Nucleotide binding

GTP

Tgene

GPN1

chr2:28152775

chr2:27872982

ENST00000458167

189_192

251

280.0

Nucleotide binding

GTP

Tgene

GPN1

chr2:28152775

chr2:27872982

ENST00000458167

29_34

251

280.0

Nucleotide binding

GTP

Tgene

GPN1

chr2:28152775

chr2:27872982

ENST00000503738

189_192

251

280.0

Nucleotide binding

GTP

Tgene

GPN1

chr2:28152775

chr2:27872982

ENST00000503738

29_34

251

280.0

Nucleotide binding

GTP

Tgene

GPN1

chr2:28152775

chr2:27872982

ENST00000515877

189_192

267

296.0

Nucleotide binding

GTP

Tgene

GPN1

chr2:28152775

chr2:27872982

ENST00000515877

29_34

267

296.0

Nucleotide binding

GTP

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Fusion Gene Sequence for BRE-GPN1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>10239_10239_1_BRE-GPN1_BRE_chr2_28152775_ENST00000342045_GPN1_chr2_27872982_ENST00000424214_length(transcript)=1076nt_BP=346nt
GGGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTCCAGAAGCAAGAGATAAAGTAATAATGGGTACTGTGGGGAAAA
ACACAGAAGAACAATTCGGTAATATAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATG
CTCTCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGC
TGCACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTTTACAGAGGAAAGC
CATGAAGAGCCAGCATTCCAGAATTTTATGCAAGAATCGATGGCACAATACTGGAAGAGAAACAATAAATAGGAGACTTTAGCACACTTC
ACTTGTTTCTAGAAGTCCAGAATTTTGGACCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGGGGCTCCCATAAGGGATAATTTTC
CTCAGAGTAGCAAAGTTTCTCTTATTAGAGAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGACCCTTGGACCTGGCAGGTTAATGC
TGATTATTCCTTGGCCTTTCCCTTGTATTTATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAAGCCTACAACTTCAAGTTTTATCA
TTTGAACTCAAGTACTTTTGCTGCTGAGGAATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCTCAGATCTCTATTATTAGGCTAGA
TGTATAGCCTCTACTCCCCCAGCTTCTTGCTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCAGCCAAGGAAAAGGGAAACATGAG
CTTATCCAGAACGGTGGCAGAGTCTCCTTGGCAATCAACCAACGTTGCTATGAAATATGCCTCACACTGTATAGCTCATTATAGGACGTC
AGGTTTGTTGAAAAAAGTGGGCAAGACATGATTAATGAATCAGAATCCTGTTTCATTGGTGACTTGGATAAAGACTTTTTAATTTT

>10239_10239_1_BRE-GPN1_BRE_chr2_28152775_ENST00000342045_GPN1_chr2_27872982_ENST00000424214_length(amino acids)=97AA_BP=1
MFLFQYCAIDSCIKFWNAGSSWLSSVNFNVSPAYGMCSLNRSQLGPGVNDVQPDFKSVILKQFVASSPTFPFRTTLDMKGESIGDIRFKA
TSGDILT

--------------------------------------------------------------
>10239_10239_2_BRE-GPN1_BRE_chr2_28152775_ENST00000342045_GPN1_chr2_27872982_ENST00000458167_length(transcript)=1076nt_BP=346nt
GGGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTCCAGAAGCAAGAGATAAAGTAATAATGGGTACTGTGGGGAAAA
ACACAGAAGAACAATTCGGTAATATAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATG
CTCTCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGC
TGCACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTTTACAGAGGAAAGC
CATGAAGAGCCAGCATTCCAGAATTTTATGCAAGAATCGATGGCACAATACTGGAAGAGAAACAATAAATAGGAGACTTTAGCACACTTC
ACTTGTTTCTAGAAGTCCAGAATTTTGGACCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGGGGCTCCCATAAGGGATAATTTTC
CTCAGAGTAGCAAAGTTTCTCTTATTAGAGAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGACCCTTGGACCTGGCAGGTTAATGC
TGATTATTCCTTGGCCTTTCCCTTGTATTTATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAAGCCTACAACTTCAAGTTTTATCA
TTTGAACTCAAGTACTTTTGCTGCTGAGGAATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCTCAGATCTCTATTATTAGGCTAGA
TGTATAGCCTCTACTCCCCCAGCTTCTTGCTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCAGCCAAGGAAAAGGGAAACATGAG
CTTATCCAGAACGGTGGCAGAGTCTCCTTGGCAATCAACCAACGTTGCTATGAAATATGCCTCACACTGTATAGCTCATTATAGGACGTC
AGGTTTGTTGAAAAAAGTGGGCAAGACATGATTAATGAATCAGAATCCTGTTTCATTGGTGACTTGGATAAAGACTTTTTAATTTT

>10239_10239_2_BRE-GPN1_BRE_chr2_28152775_ENST00000342045_GPN1_chr2_27872982_ENST00000458167_length(amino acids)=97AA_BP=1
MFLFQYCAIDSCIKFWNAGSSWLSSVNFNVSPAYGMCSLNRSQLGPGVNDVQPDFKSVILKQFVASSPTFPFRTTLDMKGESIGDIRFKA
TSGDILT

--------------------------------------------------------------
>10239_10239_3_BRE-GPN1_BRE_chr2_28152775_ENST00000344773_GPN1_chr2_27872982_ENST00000424214_length(transcript)=1073nt_BP=343nt
GAGTGCGCACGCATCCTGCCCGCGGCGCGCGCGCAGGTCGGTGCGTCTGTCGGGGGCGCGCTCGGGTACCTGTACCCCACGTAGTCGCCG
GTTACCGATCGGACTAAGTTCCAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATGCTC
TCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGCTGC
ACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTTTACAGAGGAAAGCCAT
GAAGAGCCAGCATTCCAGAATTTTATGCAAGAATCGATGGCACAATACTGGAAGAGAAACAATAAATAGGAGACTTTAGCACACTTCACT
TGTTTCTAGAAGTCCAGAATTTTGGACCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGGGGCTCCCATAAGGGATAATTTTCCTC
AGAGTAGCAAAGTTTCTCTTATTAGAGAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGACCCTTGGACCTGGCAGGTTAATGCTGA
TTATTCCTTGGCCTTTCCCTTGTATTTATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAAGCCTACAACTTCAAGTTTTATCATTT
GAACTCAAGTACTTTTGCTGCTGAGGAATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCTCAGATCTCTATTATTAGGCTAGATGT
ATAGCCTCTACTCCCCCAGCTTCTTGCTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCAGCCAAGGAAAAGGGAAACATGAGCTT
ATCCAGAACGGTGGCAGAGTCTCCTTGGCAATCAACCAACGTTGCTATGAAATATGCCTCACACTGTATAGCTCATTATAGGACGTCAGG
TTTGTTGAAAAAAGTGGGCAAGACATGATTAATGAATCAGAATCCTGTTTCATTGGTGACTTGGATAAAGACTTTTTAATTTT

>10239_10239_3_BRE-GPN1_BRE_chr2_28152775_ENST00000344773_GPN1_chr2_27872982_ENST00000424214_length(amino acids)=97AA_BP=1
MFLFQYCAIDSCIKFWNAGSSWLSSVNFNVSPAYGMCSLNRSQLGPGVNDVQPDFKSVILKQFVASSPTFPFRTTLDMKGESIGDIRFKA
TSGDILT

--------------------------------------------------------------
>10239_10239_4_BRE-GPN1_BRE_chr2_28152775_ENST00000344773_GPN1_chr2_27872982_ENST00000458167_length(transcript)=1073nt_BP=343nt
GAGTGCGCACGCATCCTGCCCGCGGCGCGCGCGCAGGTCGGTGCGTCTGTCGGGGGCGCGCTCGGGTACCTGTACCCCACGTAGTCGCCG
GTTACCGATCGGACTAAGTTCCAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATGCTC
TCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGCTGC
ACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTTTACAGAGGAAAGCCAT
GAAGAGCCAGCATTCCAGAATTTTATGCAAGAATCGATGGCACAATACTGGAAGAGAAACAATAAATAGGAGACTTTAGCACACTTCACT
TGTTTCTAGAAGTCCAGAATTTTGGACCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGGGGCTCCCATAAGGGATAATTTTCCTC
AGAGTAGCAAAGTTTCTCTTATTAGAGAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGACCCTTGGACCTGGCAGGTTAATGCTGA
TTATTCCTTGGCCTTTCCCTTGTATTTATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAAGCCTACAACTTCAAGTTTTATCATTT
GAACTCAAGTACTTTTGCTGCTGAGGAATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCTCAGATCTCTATTATTAGGCTAGATGT
ATAGCCTCTACTCCCCCAGCTTCTTGCTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCAGCCAAGGAAAAGGGAAACATGAGCTT
ATCCAGAACGGTGGCAGAGTCTCCTTGGCAATCAACCAACGTTGCTATGAAATATGCCTCACACTGTATAGCTCATTATAGGACGTCAGG
TTTGTTGAAAAAAGTGGGCAAGACATGATTAATGAATCAGAATCCTGTTTCATTGGTGACTTGGATAAAGACTTTTTAATTTT

>10239_10239_4_BRE-GPN1_BRE_chr2_28152775_ENST00000344773_GPN1_chr2_27872982_ENST00000458167_length(amino acids)=97AA_BP=1
MFLFQYCAIDSCIKFWNAGSSWLSSVNFNVSPAYGMCSLNRSQLGPGVNDVQPDFKSVILKQFVASSPTFPFRTTLDMKGESIGDIRFKA
TSGDILT

--------------------------------------------------------------
>10239_10239_5_BRE-GPN1_BRE_chr2_28152775_ENST00000361704_GPN1_chr2_27872982_ENST00000424214_length(transcript)=1009nt_BP=279nt
GGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTCCAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGG
CCTTGAACCGAATATCTCCAATGCTCTCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGA
GGATAACTGACTTAAAATCTGGCTGCACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGA
CATTAAAGTTTACAGAGGAAAGCCATGAAGAGCCAGCATTCCAGAATTTTATGCAAGAATCGATGGCACAATACTGGAAGAGAAACAATA
AATAGGAGACTTTAGCACACTTCACTTGTTTCTAGAAGTCCAGAATTTTGGACCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGG
GGCTCCCATAAGGGATAATTTTCCTCAGAGTAGCAAAGTTTCTCTTATTAGAGAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGAC
CCTTGGACCTGGCAGGTTAATGCTGATTATTCCTTGGCCTTTCCCTTGTATTTATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAA
GCCTACAACTTCAAGTTTTATCATTTGAACTCAAGTACTTTTGCTGCTGAGGAATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCT
CAGATCTCTATTATTAGGCTAGATGTATAGCCTCTACTCCCCCAGCTTCTTGCTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCA
GCCAAGGAAAAGGGAAACATGAGCTTATCCAGAACGGTGGCAGAGTCTCCTTGGCAATCAACCAACGTTGCTATGAAATATGCCTCACAC
TGTATAGCTCATTATAGGACGTCAGGTTTGTTGAAAAAAGTGGGCAAGACATGATTAATGAATCAGAATCCTGTTTCATTGGTGACTTGG
ATAAAGACTTTTTAATTTT

>10239_10239_5_BRE-GPN1_BRE_chr2_28152775_ENST00000361704_GPN1_chr2_27872982_ENST00000424214_length(amino acids)=97AA_BP=1
MFLFQYCAIDSCIKFWNAGSSWLSSVNFNVSPAYGMCSLNRSQLGPGVNDVQPDFKSVILKQFVASSPTFPFRTTLDMKGESIGDIRFKA
TSGDILT

--------------------------------------------------------------
>10239_10239_6_BRE-GPN1_BRE_chr2_28152775_ENST00000361704_GPN1_chr2_27872982_ENST00000458167_length(transcript)=1009nt_BP=279nt
GGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTCCAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGG
CCTTGAACCGAATATCTCCAATGCTCTCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGA
GGATAACTGACTTAAAATCTGGCTGCACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGA
CATTAAAGTTTACAGAGGAAAGCCATGAAGAGCCAGCATTCCAGAATTTTATGCAAGAATCGATGGCACAATACTGGAAGAGAAACAATA
AATAGGAGACTTTAGCACACTTCACTTGTTTCTAGAAGTCCAGAATTTTGGACCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGG
GGCTCCCATAAGGGATAATTTTCCTCAGAGTAGCAAAGTTTCTCTTATTAGAGAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGAC
CCTTGGACCTGGCAGGTTAATGCTGATTATTCCTTGGCCTTTCCCTTGTATTTATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAA
GCCTACAACTTCAAGTTTTATCATTTGAACTCAAGTACTTTTGCTGCTGAGGAATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCT
CAGATCTCTATTATTAGGCTAGATGTATAGCCTCTACTCCCCCAGCTTCTTGCTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCA
GCCAAGGAAAAGGGAAACATGAGCTTATCCAGAACGGTGGCAGAGTCTCCTTGGCAATCAACCAACGTTGCTATGAAATATGCCTCACAC
TGTATAGCTCATTATAGGACGTCAGGTTTGTTGAAAAAAGTGGGCAAGACATGATTAATGAATCAGAATCCTGTTTCATTGGTGACTTGG
ATAAAGACTTTTTAATTTT

>10239_10239_6_BRE-GPN1_BRE_chr2_28152775_ENST00000361704_GPN1_chr2_27872982_ENST00000458167_length(amino acids)=97AA_BP=1
MFLFQYCAIDSCIKFWNAGSSWLSSVNFNVSPAYGMCSLNRSQLGPGVNDVQPDFKSVILKQFVASSPTFPFRTTLDMKGESIGDIRFKA
TSGDILT

--------------------------------------------------------------
>10239_10239_7_BRE-GPN1_BRE_chr2_28152775_ENST00000379624_GPN1_chr2_27872982_ENST00000424214_length(transcript)=1052nt_BP=322nt
GCGGCGCGCGCGCAGGTCGGTGCGTCTGTCGGGGGCGCGCTCGGGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTC
CAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATGCTCTCCCCTTTCATATCTAGCGTG
GTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGCTGCACATCATTGACTCCTGGGCCC
AACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTTTACAGAGGAAAGCCATGAAGAGCCAGCATTCCAGAAT
TTTATGCAAGAATCGATGGCACAATACTGGAAGAGAAACAATAAATAGGAGACTTTAGCACACTTCACTTGTTTCTAGAAGTCCAGAATT
TTGGACCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGGGGCTCCCATAAGGGATAATTTTCCTCAGAGTAGCAAAGTTTCTCTTA
TTAGAGAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGACCCTTGGACCTGGCAGGTTAATGCTGATTATTCCTTGGCCTTTCCCTT
GTATTTATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAAGCCTACAACTTCAAGTTTTATCATTTGAACTCAAGTACTTTTGCTGC
TGAGGAATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCTCAGATCTCTATTATTAGGCTAGATGTATAGCCTCTACTCCCCCAGCT
TCTTGCTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCAGCCAAGGAAAAGGGAAACATGAGCTTATCCAGAACGGTGGCAGAGTC
TCCTTGGCAATCAACCAACGTTGCTATGAAATATGCCTCACACTGTATAGCTCATTATAGGACGTCAGGTTTGTTGAAAAAAGTGGGCAA
GACATGATTAATGAATCAGAATCCTGTTTCATTGGTGACTTGGATAAAGACTTTTTAATTTT

>10239_10239_7_BRE-GPN1_BRE_chr2_28152775_ENST00000379624_GPN1_chr2_27872982_ENST00000424214_length(amino acids)=97AA_BP=1
MFLFQYCAIDSCIKFWNAGSSWLSSVNFNVSPAYGMCSLNRSQLGPGVNDVQPDFKSVILKQFVASSPTFPFRTTLDMKGESIGDIRFKA
TSGDILT

--------------------------------------------------------------
>10239_10239_8_BRE-GPN1_BRE_chr2_28152775_ENST00000379624_GPN1_chr2_27872982_ENST00000458167_length(transcript)=1052nt_BP=322nt
GCGGCGCGCGCGCAGGTCGGTGCGTCTGTCGGGGGCGCGCTCGGGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTC
CAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATGCTCTCCCCTTTCATATCTAGCGTG
GTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGCTGCACATCATTGACTCCTGGGCCC
AACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTTTACAGAGGAAAGCCATGAAGAGCCAGCATTCCAGAAT
TTTATGCAAGAATCGATGGCACAATACTGGAAGAGAAACAATAAATAGGAGACTTTAGCACACTTCACTTGTTTCTAGAAGTCCAGAATT
TTGGACCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGGGGCTCCCATAAGGGATAATTTTCCTCAGAGTAGCAAAGTTTCTCTTA
TTAGAGAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGACCCTTGGACCTGGCAGGTTAATGCTGATTATTCCTTGGCCTTTCCCTT
GTATTTATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAAGCCTACAACTTCAAGTTTTATCATTTGAACTCAAGTACTTTTGCTGC
TGAGGAATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCTCAGATCTCTATTATTAGGCTAGATGTATAGCCTCTACTCCCCCAGCT
TCTTGCTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCAGCCAAGGAAAAGGGAAACATGAGCTTATCCAGAACGGTGGCAGAGTC
TCCTTGGCAATCAACCAACGTTGCTATGAAATATGCCTCACACTGTATAGCTCATTATAGGACGTCAGGTTTGTTGAAAAAAGTGGGCAA
GACATGATTAATGAATCAGAATCCTGTTTCATTGGTGACTTGGATAAAGACTTTTTAATTTT

>10239_10239_8_BRE-GPN1_BRE_chr2_28152775_ENST00000379624_GPN1_chr2_27872982_ENST00000458167_length(amino acids)=97AA_BP=1
MFLFQYCAIDSCIKFWNAGSSWLSSVNFNVSPAYGMCSLNRSQLGPGVNDVQPDFKSVILKQFVASSPTFPFRTTLDMKGESIGDIRFKA
TSGDILT

--------------------------------------------------------------
>10239_10239_9_BRE-GPN1_BRE_chr2_28152775_ENST00000379632_GPN1_chr2_27872982_ENST00000424214_length(transcript)=1075nt_BP=345nt
GGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTCCAGAAGCAAGAGATAAAGTAATAATGGGTACTGTGGGGAAAAA
CACAGAAGAACAATTCGGTAATATAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATGC
TCTCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGCT
GCACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTTTACAGAGGAAAGCC
ATGAAGAGCCAGCATTCCAGAATTTTATGCAAGAATCGATGGCACAATACTGGAAGAGAAACAATAAATAGGAGACTTTAGCACACTTCA
CTTGTTTCTAGAAGTCCAGAATTTTGGACCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGGGGCTCCCATAAGGGATAATTTTCC
TCAGAGTAGCAAAGTTTCTCTTATTAGAGAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGACCCTTGGACCTGGCAGGTTAATGCT
GATTATTCCTTGGCCTTTCCCTTGTATTTATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAAGCCTACAACTTCAAGTTTTATCAT
TTGAACTCAAGTACTTTTGCTGCTGAGGAATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCTCAGATCTCTATTATTAGGCTAGAT
GTATAGCCTCTACTCCCCCAGCTTCTTGCTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCAGCCAAGGAAAAGGGAAACATGAGC
TTATCCAGAACGGTGGCAGAGTCTCCTTGGCAATCAACCAACGTTGCTATGAAATATGCCTCACACTGTATAGCTCATTATAGGACGTCA
GGTTTGTTGAAAAAAGTGGGCAAGACATGATTAATGAATCAGAATCCTGTTTCATTGGTGACTTGGATAAAGACTTTTTAATTTT

>10239_10239_9_BRE-GPN1_BRE_chr2_28152775_ENST00000379632_GPN1_chr2_27872982_ENST00000424214_length(amino acids)=97AA_BP=1
MFLFQYCAIDSCIKFWNAGSSWLSSVNFNVSPAYGMCSLNRSQLGPGVNDVQPDFKSVILKQFVASSPTFPFRTTLDMKGESIGDIRFKA
TSGDILT

--------------------------------------------------------------
>10239_10239_10_BRE-GPN1_BRE_chr2_28152775_ENST00000379632_GPN1_chr2_27872982_ENST00000458167_length(transcript)=1075nt_BP=345nt
GGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTCCAGAAGCAAGAGATAAAGTAATAATGGGTACTGTGGGGAAAAA
CACAGAAGAACAATTCGGTAATATAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATGC
TCTCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGCT
GCACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTTTACAGAGGAAAGCC
ATGAAGAGCCAGCATTCCAGAATTTTATGCAAGAATCGATGGCACAATACTGGAAGAGAAACAATAAATAGGAGACTTTAGCACACTTCA
CTTGTTTCTAGAAGTCCAGAATTTTGGACCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGGGGCTCCCATAAGGGATAATTTTCC
TCAGAGTAGCAAAGTTTCTCTTATTAGAGAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGACCCTTGGACCTGGCAGGTTAATGCT
GATTATTCCTTGGCCTTTCCCTTGTATTTATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAAGCCTACAACTTCAAGTTTTATCAT
TTGAACTCAAGTACTTTTGCTGCTGAGGAATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCTCAGATCTCTATTATTAGGCTAGAT
GTATAGCCTCTACTCCCCCAGCTTCTTGCTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCAGCCAAGGAAAAGGGAAACATGAGC
TTATCCAGAACGGTGGCAGAGTCTCCTTGGCAATCAACCAACGTTGCTATGAAATATGCCTCACACTGTATAGCTCATTATAGGACGTCA
GGTTTGTTGAAAAAAGTGGGCAAGACATGATTAATGAATCAGAATCCTGTTTCATTGGTGACTTGGATAAAGACTTTTTAATTTT

>10239_10239_10_BRE-GPN1_BRE_chr2_28152775_ENST00000379632_GPN1_chr2_27872982_ENST00000458167_length(amino acids)=97AA_BP=1
MFLFQYCAIDSCIKFWNAGSSWLSSVNFNVSPAYGMCSLNRSQLGPGVNDVQPDFKSVILKQFVASSPTFPFRTTLDMKGESIGDIRFKA
TSGDILT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for BRE-GPN1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for BRE-GPN1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for BRE-GPN1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene		C0026640	Mouth Neoplasms	1	CTD_human
Tgene		C0153381	Malignant neoplasm of mouth	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:BRE-GPN1 (FusionGDB2 ID:HG9577TG11321)

Fusion Gene Summary for BRE-GPN1

Fusion Gene ORF analysis for BRE-GPN1

Fusion Genomic Features for BRE-GPN1

Fusion Protein Features for BRE-GPN1

Fusion Gene Sequence for BRE-GPN1

Fusion Gene PPI Analysis for BRE-GPN1

Related Drugs for BRE-GPN1

Related Diseases for BRE-GPN1

Fusion Gene Studies
in Kim Lab