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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BRE-GPN1 (FusionGDB2 ID:HG9577TG11321)

Fusion Gene Summary for BRE-GPN1

check button Fusion gene summary
Fusion gene informationFusion gene name: BRE-GPN1
Fusion gene ID: hg9577tg11321
HgeneTgene
Gene symbol

BRE

GPN1

Gene ID

9577

11321

Gene nameBRISC and BRCA1 A complex member 2GPN-loop GTPase 1
SynonymsBRCC4|BRCC45|BREATPBD1A|MBDIN|NTPBP|RPAP4|XAB1
Cytomap('BRE')('GPN1')

2p23.2

2p23.3

Type of geneprotein-codingprotein-coding
DescriptionBRISC and BRCA1-A complex member 2BRCA1-A complex subunit BREBRCA1/BRCA2-containing complex subunit 45BRCA1/BRCA2-containing complex, subunit 4brain and reproductive organ-expressed (TNFRSF1A modulator)brain and reproductive organ-expressed proteinGPN-loop GTPase 1ATP(GTP)-binding proteinMBD2-interacting proteinRNA polymerase II associated protein 4RNAPII-associated protein 4XPA binding protein 1, GTPase
Modification date2020031320200328
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000603461, ENST00000342045, 
ENST00000344773, ENST00000361704, 
ENST00000379624, ENST00000379632, 
Fusion gene scores* DoF score13 X 9 X 8=9367 X 8 X 7=392
# samples 1511
** MAII scorelog2(15/936*10)=-2.64154602908752
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/392*10)=-1.83335013059055
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRE [Title/Abstract] AND GPN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBRE(28152775)-GPN1(27872982), # samples:2
BRE(28117551)-GPN1(27870703), # samples:2
Anticipated loss of major functional domain due to fusion event.BRE-GPN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BRE-GPN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BRE-GPN1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
BRE-GPN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
BRE-GPN1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBRE

GO:0043066

negative regulation of apoptotic process

15465831


check buttonFusion gene breakpoints across BRE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across GPN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A91K-01ABREchr2

28152775

+GPN1chr2

27852726

+
ChimerDB4STADTCGA-VQ-A91KBREchr2

28152775

+GPN1chr2

27852725

+
ChimerDB4UCECTCGA-B5-A0JN-01ABREchr2

28152775

-GPN1chr2

27872982

+
ChimerDB4UCECTCGA-B5-A0JN-01ABREchr2

28152775

+GPN1chr2

27872982

+
ChimerDB4UCSTCGA-N9-A4Q1-01ABREchr2

28117551

-GPN1chr2

27870703

+
ChimerDB4UCSTCGA-N9-A4Q1BREchr2

28117551

+GPN1chr2

27870703

+


Top

Fusion Gene ORF analysis for BRE-GPN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000603461ENST00000264718BREchr2

28152775

+GPN1chr2

27872982

+
3UTR-3CDSENST00000603461ENST00000407583BREchr2

28152775

+GPN1chr2

27872982

+
3UTR-3CDSENST00000603461ENST00000424214BREchr2

28152775

+GPN1chr2

27872982

+
3UTR-3CDSENST00000603461ENST00000458167BREchr2

28152775

+GPN1chr2

27872982

+
3UTR-3CDSENST00000603461ENST00000503738BREchr2

28152775

+GPN1chr2

27872982

+
3UTR-3CDSENST00000603461ENST00000515877BREchr2

28152775

+GPN1chr2

27872982

+
3UTR-3CDSENST00000603461ENST00000610189BREchr2

28152775

+GPN1chr2

27872982

+
3UTR-3UTRENST00000603461ENST00000461249BREchr2

28152775

+GPN1chr2

27852726

+
3UTR-3UTRENST00000603461ENST00000461249BREchr2

28152775

+GPN1chr2

27852725

+
3UTR-5UTRENST00000603461ENST00000264718BREchr2

28152775

+GPN1chr2

27852726

+
3UTR-5UTRENST00000603461ENST00000264718BREchr2

28152775

+GPN1chr2

27852725

+
3UTR-5UTRENST00000603461ENST00000407583BREchr2

28152775

+GPN1chr2

27852726

+
3UTR-5UTRENST00000603461ENST00000407583BREchr2

28152775

+GPN1chr2

27852725

+
3UTR-5UTRENST00000603461ENST00000424214BREchr2

28152775

+GPN1chr2

27852726

+
3UTR-5UTRENST00000603461ENST00000424214BREchr2

28152775

+GPN1chr2

27852725

+
3UTR-5UTRENST00000603461ENST00000458167BREchr2

28152775

+GPN1chr2

27852726

+
3UTR-5UTRENST00000603461ENST00000458167BREchr2

28152775

+GPN1chr2

27852725

+
3UTR-5UTRENST00000603461ENST00000610189BREchr2

28152775

+GPN1chr2

27852726

+
3UTR-5UTRENST00000603461ENST00000610189BREchr2

28152775

+GPN1chr2

27852725

+
3UTR-intronENST00000603461ENST00000461249BREchr2

28152775

+GPN1chr2

27872982

+
3UTR-intronENST00000603461ENST00000503738BREchr2

28152775

+GPN1chr2

27852726

+
3UTR-intronENST00000603461ENST00000503738BREchr2

28152775

+GPN1chr2

27852725

+
3UTR-intronENST00000603461ENST00000515877BREchr2

28152775

+GPN1chr2

27852726

+
3UTR-intronENST00000603461ENST00000515877BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-3UTRENST00000342045ENST00000461249BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-3UTRENST00000342045ENST00000461249BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-3UTRENST00000342045ENST00000461249BREchr2

28117551

+GPN1chr2

27870703

+
5CDS-3UTRENST00000344773ENST00000461249BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-3UTRENST00000344773ENST00000461249BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-3UTRENST00000344773ENST00000461249BREchr2

28117551

+GPN1chr2

27870703

+
5CDS-3UTRENST00000361704ENST00000461249BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-3UTRENST00000361704ENST00000461249BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-3UTRENST00000361704ENST00000461249BREchr2

28117551

+GPN1chr2

27870703

+
5CDS-3UTRENST00000379624ENST00000461249BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-3UTRENST00000379624ENST00000461249BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-3UTRENST00000379624ENST00000461249BREchr2

28117551

+GPN1chr2

27870703

+
5CDS-3UTRENST00000379632ENST00000461249BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-3UTRENST00000379632ENST00000461249BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-3UTRENST00000379632ENST00000461249BREchr2

28117551

+GPN1chr2

27870703

+
5CDS-5UTRENST00000342045ENST00000264718BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000342045ENST00000264718BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000342045ENST00000407583BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000342045ENST00000407583BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000342045ENST00000424214BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000342045ENST00000424214BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000342045ENST00000458167BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000342045ENST00000458167BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000342045ENST00000610189BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000342045ENST00000610189BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000344773ENST00000264718BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000344773ENST00000264718BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000344773ENST00000407583BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000344773ENST00000407583BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000344773ENST00000424214BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000344773ENST00000424214BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000344773ENST00000458167BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000344773ENST00000458167BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000344773ENST00000610189BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000344773ENST00000610189BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000361704ENST00000264718BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000361704ENST00000264718BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000361704ENST00000407583BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000361704ENST00000407583BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000361704ENST00000424214BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000361704ENST00000424214BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000361704ENST00000458167BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000361704ENST00000458167BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000361704ENST00000610189BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000361704ENST00000610189BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000379624ENST00000264718BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000379624ENST00000264718BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000379624ENST00000407583BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000379624ENST00000407583BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000379624ENST00000424214BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000379624ENST00000424214BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000379624ENST00000458167BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000379624ENST00000458167BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000379624ENST00000610189BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000379624ENST00000610189BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000379632ENST00000264718BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000379632ENST00000264718BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000379632ENST00000407583BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000379632ENST00000407583BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000379632ENST00000424214BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000379632ENST00000424214BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000379632ENST00000458167BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000379632ENST00000458167BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-5UTRENST00000379632ENST00000610189BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-5UTRENST00000379632ENST00000610189BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-intronENST00000342045ENST00000461249BREchr2

28152775

+GPN1chr2

27872982

+
5CDS-intronENST00000342045ENST00000503738BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-intronENST00000342045ENST00000503738BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-intronENST00000342045ENST00000515877BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-intronENST00000342045ENST00000515877BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-intronENST00000344773ENST00000461249BREchr2

28152775

+GPN1chr2

27872982

+
5CDS-intronENST00000344773ENST00000503738BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-intronENST00000344773ENST00000503738BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-intronENST00000344773ENST00000515877BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-intronENST00000344773ENST00000515877BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-intronENST00000361704ENST00000461249BREchr2

28152775

+GPN1chr2

27872982

+
5CDS-intronENST00000361704ENST00000503738BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-intronENST00000361704ENST00000503738BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-intronENST00000361704ENST00000515877BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-intronENST00000361704ENST00000515877BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-intronENST00000379624ENST00000461249BREchr2

28152775

+GPN1chr2

27872982

+
5CDS-intronENST00000379624ENST00000503738BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-intronENST00000379624ENST00000503738BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-intronENST00000379624ENST00000515877BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-intronENST00000379624ENST00000515877BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-intronENST00000379632ENST00000461249BREchr2

28152775

+GPN1chr2

27872982

+
5CDS-intronENST00000379632ENST00000503738BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-intronENST00000379632ENST00000503738BREchr2

28152775

+GPN1chr2

27852725

+
5CDS-intronENST00000379632ENST00000515877BREchr2

28152775

+GPN1chr2

27852726

+
5CDS-intronENST00000379632ENST00000515877BREchr2

28152775

+GPN1chr2

27852725

+
Frame-shiftENST00000342045ENST00000264718BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000342045ENST00000264718BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000342045ENST00000407583BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000342045ENST00000407583BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000342045ENST00000424214BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000342045ENST00000458167BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000342045ENST00000503738BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000342045ENST00000503738BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000342045ENST00000515877BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000342045ENST00000515877BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000342045ENST00000610189BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000342045ENST00000610189BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000344773ENST00000264718BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000344773ENST00000264718BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000344773ENST00000407583BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000344773ENST00000407583BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000344773ENST00000424214BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000344773ENST00000458167BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000344773ENST00000503738BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000344773ENST00000503738BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000344773ENST00000515877BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000344773ENST00000515877BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000344773ENST00000610189BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000344773ENST00000610189BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000361704ENST00000264718BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000361704ENST00000264718BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000361704ENST00000407583BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000361704ENST00000407583BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000361704ENST00000424214BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000361704ENST00000458167BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000361704ENST00000503738BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000361704ENST00000503738BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000361704ENST00000515877BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000361704ENST00000515877BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000361704ENST00000610189BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000361704ENST00000610189BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000379624ENST00000264718BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000379624ENST00000264718BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000379624ENST00000407583BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000379624ENST00000407583BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000379624ENST00000424214BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000379624ENST00000458167BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000379624ENST00000503738BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000379624ENST00000503738BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000379624ENST00000515877BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000379624ENST00000515877BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000379624ENST00000610189BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000379624ENST00000610189BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000379632ENST00000264718BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000379632ENST00000264718BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000379632ENST00000407583BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000379632ENST00000407583BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000379632ENST00000424214BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000379632ENST00000458167BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000379632ENST00000503738BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000379632ENST00000503738BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000379632ENST00000515877BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000379632ENST00000515877BREchr2

28117551

+GPN1chr2

27870703

+
Frame-shiftENST00000379632ENST00000610189BREchr2

28152775

+GPN1chr2

27872982

+
Frame-shiftENST00000379632ENST00000610189BREchr2

28117551

+GPN1chr2

27870703

+
In-frameENST00000342045ENST00000424214BREchr2

28152775

+GPN1chr2

27872982

+
In-frameENST00000342045ENST00000458167BREchr2

28152775

+GPN1chr2

27872982

+
In-frameENST00000344773ENST00000424214BREchr2

28152775

+GPN1chr2

27872982

+
In-frameENST00000344773ENST00000458167BREchr2

28152775

+GPN1chr2

27872982

+
In-frameENST00000361704ENST00000424214BREchr2

28152775

+GPN1chr2

27872982

+
In-frameENST00000361704ENST00000458167BREchr2

28152775

+GPN1chr2

27872982

+
In-frameENST00000379624ENST00000424214BREchr2

28152775

+GPN1chr2

27872982

+
In-frameENST00000379624ENST00000458167BREchr2

28152775

+GPN1chr2

27872982

+
In-frameENST00000379632ENST00000424214BREchr2

28152775

+GPN1chr2

27872982

+
In-frameENST00000379632ENST00000458167BREchr2

28152775

+GPN1chr2

27872982

+
intron-3CDSENST00000603461ENST00000264718BREchr2

28117551

+GPN1chr2

27870703

+
intron-3CDSENST00000603461ENST00000407583BREchr2

28117551

+GPN1chr2

27870703

+
intron-3CDSENST00000603461ENST00000424214BREchr2

28117551

+GPN1chr2

27870703

+
intron-3CDSENST00000603461ENST00000458167BREchr2

28117551

+GPN1chr2

27870703

+
intron-3CDSENST00000603461ENST00000503738BREchr2

28117551

+GPN1chr2

27870703

+
intron-3CDSENST00000603461ENST00000515877BREchr2

28117551

+GPN1chr2

27870703

+
intron-3CDSENST00000603461ENST00000610189BREchr2

28117551

+GPN1chr2

27870703

+
intron-3UTRENST00000603461ENST00000461249BREchr2

28117551

+GPN1chr2

27870703

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000344773BREchr228152775+ENST00000458167GPN1chr227872982+107334342112897
ENST00000344773BREchr228152775+ENST00000424214GPN1chr227872982+107334342112897
ENST00000379624BREchr228152775+ENST00000458167GPN1chr227872982+105232240010797
ENST00000379624BREchr228152775+ENST00000424214GPN1chr227872982+105232240010797
ENST00000342045BREchr228152775+ENST00000458167GPN1chr227872982+107634642413197
ENST00000342045BREchr228152775+ENST00000424214GPN1chr227872982+107634642413197
ENST00000379632BREchr228152775+ENST00000458167GPN1chr227872982+107534542313097
ENST00000379632BREchr228152775+ENST00000424214GPN1chr227872982+107534542313097
ENST00000361704BREchr228152775+ENST00000458167GPN1chr227872982+10092793576497
ENST00000361704BREchr228152775+ENST00000424214GPN1chr227872982+10092793576497

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344773ENST00000458167BREchr228152775+GPN1chr227872982+0.0494543130.9505457
ENST00000344773ENST00000424214BREchr228152775+GPN1chr227872982+0.0494543130.9505457
ENST00000379624ENST00000458167BREchr228152775+GPN1chr227872982+0.0885082560.91149175
ENST00000379624ENST00000424214BREchr228152775+GPN1chr227872982+0.0885082560.91149175
ENST00000342045ENST00000458167BREchr228152775+GPN1chr227872982+0.0627409440.937259
ENST00000342045ENST00000424214BREchr228152775+GPN1chr227872982+0.0627409440.937259
ENST00000379632ENST00000458167BREchr228152775+GPN1chr227872982+0.059377890.9406221
ENST00000379632ENST00000424214BREchr228152775+GPN1chr227872982+0.059377890.9406221
ENST00000361704ENST00000458167BREchr228152775+GPN1chr227872982+0.0726197660.92738026
ENST00000361704ENST00000424214BREchr228152775+GPN1chr227872982+0.0726197660.92738026

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Fusion Genomic Features for BRE-GPN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BREchr228117551+GPN1chr227870702+0.0001910270.99980897
BREchr228152775+GPN1chr227852725+4.05E-070.99999964
BREchr228152775+GPN1chr227852725+4.05E-070.99999964
BREchr228152775+GPN1chr227872981+4.74E-101
BREchr228117551+GPN1chr227870702+0.0001910270.99980897
BREchr228152775+GPN1chr227852725+4.05E-070.99999964
BREchr228152775+GPN1chr227852725+4.05E-070.99999964
BREchr228152775+GPN1chr227872981+4.74E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BRE-GPN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:28152775/chr2:27872982)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBREchr2:28152775chr2:27872982ENST00000342045+413275_36468384.0RegionNote=UEV-like 2
HgeneBREchr2:28152775chr2:27872982ENST00000342045+41330_14768384.0RegionNote=UEV-like 1
HgeneBREchr2:28152775chr2:27872982ENST00000344773+313275_36468528.6666666666666RegionNote=UEV-like 2
HgeneBREchr2:28152775chr2:27872982ENST00000344773+31330_14768528.6666666666666RegionNote=UEV-like 1
HgeneBREchr2:28152775chr2:27872982ENST00000361704+313275_36468511.0RegionNote=UEV-like 2
HgeneBREchr2:28152775chr2:27872982ENST00000361704+31330_14768511.0RegionNote=UEV-like 1
HgeneBREchr2:28152775chr2:27872982ENST00000379624+312275_36468384.0RegionNote=UEV-like 2
HgeneBREchr2:28152775chr2:27872982ENST00000379624+31230_14768384.0RegionNote=UEV-like 1
HgeneBREchr2:28152775chr2:27872982ENST00000379632+414275_36468511.0RegionNote=UEV-like 2
HgeneBREchr2:28152775chr2:27872982ENST00000379632+41430_14768511.0RegionNote=UEV-like 1
TgeneGPN1chr2:28152775chr2:27872982ENST00000407583131586_88334363.0MotifGly-Pro-Asn (GPN)-loop%3B involved in dimer interface
TgeneGPN1chr2:28152775chr2:27872982ENST00000424214121486_88267296.0MotifGly-Pro-Asn (GPN)-loop%3B involved in dimer interface
TgeneGPN1chr2:28152775chr2:27872982ENST00000458167101286_88251280.0MotifGly-Pro-Asn (GPN)-loop%3B involved in dimer interface
TgeneGPN1chr2:28152775chr2:27872982ENST00000503738101286_88251280.0MotifGly-Pro-Asn (GPN)-loop%3B involved in dimer interface
TgeneGPN1chr2:28152775chr2:27872982ENST00000515877121486_88267296.0MotifGly-Pro-Asn (GPN)-loop%3B involved in dimer interface
TgeneGPN1chr2:28152775chr2:27872982ENST000004075831315189_192334363.0Nucleotide bindingGTP
TgeneGPN1chr2:28152775chr2:27872982ENST00000407583131529_34334363.0Nucleotide bindingGTP
TgeneGPN1chr2:28152775chr2:27872982ENST000004242141214189_192267296.0Nucleotide bindingGTP
TgeneGPN1chr2:28152775chr2:27872982ENST00000424214121429_34267296.0Nucleotide bindingGTP
TgeneGPN1chr2:28152775chr2:27872982ENST000004581671012189_192251280.0Nucleotide bindingGTP
TgeneGPN1chr2:28152775chr2:27872982ENST00000458167101229_34251280.0Nucleotide bindingGTP
TgeneGPN1chr2:28152775chr2:27872982ENST000005037381012189_192251280.0Nucleotide bindingGTP
TgeneGPN1chr2:28152775chr2:27872982ENST00000503738101229_34251280.0Nucleotide bindingGTP
TgeneGPN1chr2:28152775chr2:27872982ENST000005158771214189_192267296.0Nucleotide bindingGTP
TgeneGPN1chr2:28152775chr2:27872982ENST00000515877121429_34267296.0Nucleotide bindingGTP


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Fusion Gene Sequence for BRE-GPN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10239_10239_1_BRE-GPN1_BRE_chr2_28152775_ENST00000342045_GPN1_chr2_27872982_ENST00000424214_length(transcript)=1076nt_BP=346nt
GGGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTCCAGAAGCAAGAGATAAAGTAATAATGGGTACTGTGGGGAAAA
ACACAGAAGAACAATTCGGTAATATAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATG
CTCTCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGC
TGCACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTTTACAGAGGAAAGC
CATGAAGAGCCAGCATTCCAGAATTTTATGCAAGAATCGATGGCACAATACTGGAAGAGAAACAATAAATAGGAGACTTTAGCACACTTC
ACTTGTTTCTAGAAGTCCAGAATTTTGGACCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGGGGCTCCCATAAGGGATAATTTTC
CTCAGAGTAGCAAAGTTTCTCTTATTAGAGAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGACCCTTGGACCTGGCAGGTTAATGC
TGATTATTCCTTGGCCTTTCCCTTGTATTTATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAAGCCTACAACTTCAAGTTTTATCA
TTTGAACTCAAGTACTTTTGCTGCTGAGGAATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCTCAGATCTCTATTATTAGGCTAGA
TGTATAGCCTCTACTCCCCCAGCTTCTTGCTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCAGCCAAGGAAAAGGGAAACATGAG
CTTATCCAGAACGGTGGCAGAGTCTCCTTGGCAATCAACCAACGTTGCTATGAAATATGCCTCACACTGTATAGCTCATTATAGGACGTC

>10239_10239_1_BRE-GPN1_BRE_chr2_28152775_ENST00000342045_GPN1_chr2_27872982_ENST00000424214_length(amino acids)=97AA_BP=1
MFLFQYCAIDSCIKFWNAGSSWLSSVNFNVSPAYGMCSLNRSQLGPGVNDVQPDFKSVILKQFVASSPTFPFRTTLDMKGESIGDIRFKA

--------------------------------------------------------------
>10239_10239_2_BRE-GPN1_BRE_chr2_28152775_ENST00000342045_GPN1_chr2_27872982_ENST00000458167_length(transcript)=1076nt_BP=346nt
GGGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTCCAGAAGCAAGAGATAAAGTAATAATGGGTACTGTGGGGAAAA
ACACAGAAGAACAATTCGGTAATATAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATG
CTCTCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGC
TGCACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTTTACAGAGGAAAGC
CATGAAGAGCCAGCATTCCAGAATTTTATGCAAGAATCGATGGCACAATACTGGAAGAGAAACAATAAATAGGAGACTTTAGCACACTTC
ACTTGTTTCTAGAAGTCCAGAATTTTGGACCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGGGGCTCCCATAAGGGATAATTTTC
CTCAGAGTAGCAAAGTTTCTCTTATTAGAGAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGACCCTTGGACCTGGCAGGTTAATGC
TGATTATTCCTTGGCCTTTCCCTTGTATTTATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAAGCCTACAACTTCAAGTTTTATCA
TTTGAACTCAAGTACTTTTGCTGCTGAGGAATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCTCAGATCTCTATTATTAGGCTAGA
TGTATAGCCTCTACTCCCCCAGCTTCTTGCTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCAGCCAAGGAAAAGGGAAACATGAG
CTTATCCAGAACGGTGGCAGAGTCTCCTTGGCAATCAACCAACGTTGCTATGAAATATGCCTCACACTGTATAGCTCATTATAGGACGTC

>10239_10239_2_BRE-GPN1_BRE_chr2_28152775_ENST00000342045_GPN1_chr2_27872982_ENST00000458167_length(amino acids)=97AA_BP=1
MFLFQYCAIDSCIKFWNAGSSWLSSVNFNVSPAYGMCSLNRSQLGPGVNDVQPDFKSVILKQFVASSPTFPFRTTLDMKGESIGDIRFKA

--------------------------------------------------------------
>10239_10239_3_BRE-GPN1_BRE_chr2_28152775_ENST00000344773_GPN1_chr2_27872982_ENST00000424214_length(transcript)=1073nt_BP=343nt
GAGTGCGCACGCATCCTGCCCGCGGCGCGCGCGCAGGTCGGTGCGTCTGTCGGGGGCGCGCTCGGGTACCTGTACCCCACGTAGTCGCCG
GTTACCGATCGGACTAAGTTCCAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATGCTC
TCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGCTGC
ACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTTTACAGAGGAAAGCCAT
GAAGAGCCAGCATTCCAGAATTTTATGCAAGAATCGATGGCACAATACTGGAAGAGAAACAATAAATAGGAGACTTTAGCACACTTCACT
TGTTTCTAGAAGTCCAGAATTTTGGACCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGGGGCTCCCATAAGGGATAATTTTCCTC
AGAGTAGCAAAGTTTCTCTTATTAGAGAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGACCCTTGGACCTGGCAGGTTAATGCTGA
TTATTCCTTGGCCTTTCCCTTGTATTTATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAAGCCTACAACTTCAAGTTTTATCATTT
GAACTCAAGTACTTTTGCTGCTGAGGAATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCTCAGATCTCTATTATTAGGCTAGATGT
ATAGCCTCTACTCCCCCAGCTTCTTGCTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCAGCCAAGGAAAAGGGAAACATGAGCTT
ATCCAGAACGGTGGCAGAGTCTCCTTGGCAATCAACCAACGTTGCTATGAAATATGCCTCACACTGTATAGCTCATTATAGGACGTCAGG

>10239_10239_3_BRE-GPN1_BRE_chr2_28152775_ENST00000344773_GPN1_chr2_27872982_ENST00000424214_length(amino acids)=97AA_BP=1
MFLFQYCAIDSCIKFWNAGSSWLSSVNFNVSPAYGMCSLNRSQLGPGVNDVQPDFKSVILKQFVASSPTFPFRTTLDMKGESIGDIRFKA

--------------------------------------------------------------
>10239_10239_4_BRE-GPN1_BRE_chr2_28152775_ENST00000344773_GPN1_chr2_27872982_ENST00000458167_length(transcript)=1073nt_BP=343nt
GAGTGCGCACGCATCCTGCCCGCGGCGCGCGCGCAGGTCGGTGCGTCTGTCGGGGGCGCGCTCGGGTACCTGTACCCCACGTAGTCGCCG
GTTACCGATCGGACTAAGTTCCAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATGCTC
TCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGCTGC
ACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTTTACAGAGGAAAGCCAT
GAAGAGCCAGCATTCCAGAATTTTATGCAAGAATCGATGGCACAATACTGGAAGAGAAACAATAAATAGGAGACTTTAGCACACTTCACT
TGTTTCTAGAAGTCCAGAATTTTGGACCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGGGGCTCCCATAAGGGATAATTTTCCTC
AGAGTAGCAAAGTTTCTCTTATTAGAGAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGACCCTTGGACCTGGCAGGTTAATGCTGA
TTATTCCTTGGCCTTTCCCTTGTATTTATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAAGCCTACAACTTCAAGTTTTATCATTT
GAACTCAAGTACTTTTGCTGCTGAGGAATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCTCAGATCTCTATTATTAGGCTAGATGT
ATAGCCTCTACTCCCCCAGCTTCTTGCTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCAGCCAAGGAAAAGGGAAACATGAGCTT
ATCCAGAACGGTGGCAGAGTCTCCTTGGCAATCAACCAACGTTGCTATGAAATATGCCTCACACTGTATAGCTCATTATAGGACGTCAGG

>10239_10239_4_BRE-GPN1_BRE_chr2_28152775_ENST00000344773_GPN1_chr2_27872982_ENST00000458167_length(amino acids)=97AA_BP=1
MFLFQYCAIDSCIKFWNAGSSWLSSVNFNVSPAYGMCSLNRSQLGPGVNDVQPDFKSVILKQFVASSPTFPFRTTLDMKGESIGDIRFKA

--------------------------------------------------------------
>10239_10239_5_BRE-GPN1_BRE_chr2_28152775_ENST00000361704_GPN1_chr2_27872982_ENST00000424214_length(transcript)=1009nt_BP=279nt
GGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTCCAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGG
CCTTGAACCGAATATCTCCAATGCTCTCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGA
GGATAACTGACTTAAAATCTGGCTGCACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGA
CATTAAAGTTTACAGAGGAAAGCCATGAAGAGCCAGCATTCCAGAATTTTATGCAAGAATCGATGGCACAATACTGGAAGAGAAACAATA
AATAGGAGACTTTAGCACACTTCACTTGTTTCTAGAAGTCCAGAATTTTGGACCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGG
GGCTCCCATAAGGGATAATTTTCCTCAGAGTAGCAAAGTTTCTCTTATTAGAGAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGAC
CCTTGGACCTGGCAGGTTAATGCTGATTATTCCTTGGCCTTTCCCTTGTATTTATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAA
GCCTACAACTTCAAGTTTTATCATTTGAACTCAAGTACTTTTGCTGCTGAGGAATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCT
CAGATCTCTATTATTAGGCTAGATGTATAGCCTCTACTCCCCCAGCTTCTTGCTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCA
GCCAAGGAAAAGGGAAACATGAGCTTATCCAGAACGGTGGCAGAGTCTCCTTGGCAATCAACCAACGTTGCTATGAAATATGCCTCACAC
TGTATAGCTCATTATAGGACGTCAGGTTTGTTGAAAAAAGTGGGCAAGACATGATTAATGAATCAGAATCCTGTTTCATTGGTGACTTGG

>10239_10239_5_BRE-GPN1_BRE_chr2_28152775_ENST00000361704_GPN1_chr2_27872982_ENST00000424214_length(amino acids)=97AA_BP=1
MFLFQYCAIDSCIKFWNAGSSWLSSVNFNVSPAYGMCSLNRSQLGPGVNDVQPDFKSVILKQFVASSPTFPFRTTLDMKGESIGDIRFKA

--------------------------------------------------------------
>10239_10239_6_BRE-GPN1_BRE_chr2_28152775_ENST00000361704_GPN1_chr2_27872982_ENST00000458167_length(transcript)=1009nt_BP=279nt
GGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTCCAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGG
CCTTGAACCGAATATCTCCAATGCTCTCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGA
GGATAACTGACTTAAAATCTGGCTGCACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGA
CATTAAAGTTTACAGAGGAAAGCCATGAAGAGCCAGCATTCCAGAATTTTATGCAAGAATCGATGGCACAATACTGGAAGAGAAACAATA
AATAGGAGACTTTAGCACACTTCACTTGTTTCTAGAAGTCCAGAATTTTGGACCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGG
GGCTCCCATAAGGGATAATTTTCCTCAGAGTAGCAAAGTTTCTCTTATTAGAGAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGAC
CCTTGGACCTGGCAGGTTAATGCTGATTATTCCTTGGCCTTTCCCTTGTATTTATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAA
GCCTACAACTTCAAGTTTTATCATTTGAACTCAAGTACTTTTGCTGCTGAGGAATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCT
CAGATCTCTATTATTAGGCTAGATGTATAGCCTCTACTCCCCCAGCTTCTTGCTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCA
GCCAAGGAAAAGGGAAACATGAGCTTATCCAGAACGGTGGCAGAGTCTCCTTGGCAATCAACCAACGTTGCTATGAAATATGCCTCACAC
TGTATAGCTCATTATAGGACGTCAGGTTTGTTGAAAAAAGTGGGCAAGACATGATTAATGAATCAGAATCCTGTTTCATTGGTGACTTGG

>10239_10239_6_BRE-GPN1_BRE_chr2_28152775_ENST00000361704_GPN1_chr2_27872982_ENST00000458167_length(amino acids)=97AA_BP=1
MFLFQYCAIDSCIKFWNAGSSWLSSVNFNVSPAYGMCSLNRSQLGPGVNDVQPDFKSVILKQFVASSPTFPFRTTLDMKGESIGDIRFKA

--------------------------------------------------------------
>10239_10239_7_BRE-GPN1_BRE_chr2_28152775_ENST00000379624_GPN1_chr2_27872982_ENST00000424214_length(transcript)=1052nt_BP=322nt
GCGGCGCGCGCGCAGGTCGGTGCGTCTGTCGGGGGCGCGCTCGGGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTC
CAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATGCTCTCCCCTTTCATATCTAGCGTG
GTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGCTGCACATCATTGACTCCTGGGCCC
AACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTTTACAGAGGAAAGCCATGAAGAGCCAGCATTCCAGAAT
TTTATGCAAGAATCGATGGCACAATACTGGAAGAGAAACAATAAATAGGAGACTTTAGCACACTTCACTTGTTTCTAGAAGTCCAGAATT
TTGGACCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGGGGCTCCCATAAGGGATAATTTTCCTCAGAGTAGCAAAGTTTCTCTTA
TTAGAGAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGACCCTTGGACCTGGCAGGTTAATGCTGATTATTCCTTGGCCTTTCCCTT
GTATTTATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAAGCCTACAACTTCAAGTTTTATCATTTGAACTCAAGTACTTTTGCTGC
TGAGGAATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCTCAGATCTCTATTATTAGGCTAGATGTATAGCCTCTACTCCCCCAGCT
TCTTGCTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCAGCCAAGGAAAAGGGAAACATGAGCTTATCCAGAACGGTGGCAGAGTC
TCCTTGGCAATCAACCAACGTTGCTATGAAATATGCCTCACACTGTATAGCTCATTATAGGACGTCAGGTTTGTTGAAAAAAGTGGGCAA

>10239_10239_7_BRE-GPN1_BRE_chr2_28152775_ENST00000379624_GPN1_chr2_27872982_ENST00000424214_length(amino acids)=97AA_BP=1
MFLFQYCAIDSCIKFWNAGSSWLSSVNFNVSPAYGMCSLNRSQLGPGVNDVQPDFKSVILKQFVASSPTFPFRTTLDMKGESIGDIRFKA

--------------------------------------------------------------
>10239_10239_8_BRE-GPN1_BRE_chr2_28152775_ENST00000379624_GPN1_chr2_27872982_ENST00000458167_length(transcript)=1052nt_BP=322nt
GCGGCGCGCGCGCAGGTCGGTGCGTCTGTCGGGGGCGCGCTCGGGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTC
CAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATGCTCTCCCCTTTCATATCTAGCGTG
GTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGCTGCACATCATTGACTCCTGGGCCC
AACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTTTACAGAGGAAAGCCATGAAGAGCCAGCATTCCAGAAT
TTTATGCAAGAATCGATGGCACAATACTGGAAGAGAAACAATAAATAGGAGACTTTAGCACACTTCACTTGTTTCTAGAAGTCCAGAATT
TTGGACCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGGGGCTCCCATAAGGGATAATTTTCCTCAGAGTAGCAAAGTTTCTCTTA
TTAGAGAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGACCCTTGGACCTGGCAGGTTAATGCTGATTATTCCTTGGCCTTTCCCTT
GTATTTATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAAGCCTACAACTTCAAGTTTTATCATTTGAACTCAAGTACTTTTGCTGC
TGAGGAATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCTCAGATCTCTATTATTAGGCTAGATGTATAGCCTCTACTCCCCCAGCT
TCTTGCTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCAGCCAAGGAAAAGGGAAACATGAGCTTATCCAGAACGGTGGCAGAGTC
TCCTTGGCAATCAACCAACGTTGCTATGAAATATGCCTCACACTGTATAGCTCATTATAGGACGTCAGGTTTGTTGAAAAAAGTGGGCAA

>10239_10239_8_BRE-GPN1_BRE_chr2_28152775_ENST00000379624_GPN1_chr2_27872982_ENST00000458167_length(amino acids)=97AA_BP=1
MFLFQYCAIDSCIKFWNAGSSWLSSVNFNVSPAYGMCSLNRSQLGPGVNDVQPDFKSVILKQFVASSPTFPFRTTLDMKGESIGDIRFKA

--------------------------------------------------------------
>10239_10239_9_BRE-GPN1_BRE_chr2_28152775_ENST00000379632_GPN1_chr2_27872982_ENST00000424214_length(transcript)=1075nt_BP=345nt
GGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTCCAGAAGCAAGAGATAAAGTAATAATGGGTACTGTGGGGAAAAA
CACAGAAGAACAATTCGGTAATATAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATGC
TCTCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGCT
GCACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTTTACAGAGGAAAGCC
ATGAAGAGCCAGCATTCCAGAATTTTATGCAAGAATCGATGGCACAATACTGGAAGAGAAACAATAAATAGGAGACTTTAGCACACTTCA
CTTGTTTCTAGAAGTCCAGAATTTTGGACCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGGGGCTCCCATAAGGGATAATTTTCC
TCAGAGTAGCAAAGTTTCTCTTATTAGAGAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGACCCTTGGACCTGGCAGGTTAATGCT
GATTATTCCTTGGCCTTTCCCTTGTATTTATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAAGCCTACAACTTCAAGTTTTATCAT
TTGAACTCAAGTACTTTTGCTGCTGAGGAATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCTCAGATCTCTATTATTAGGCTAGAT
GTATAGCCTCTACTCCCCCAGCTTCTTGCTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCAGCCAAGGAAAAGGGAAACATGAGC
TTATCCAGAACGGTGGCAGAGTCTCCTTGGCAATCAACCAACGTTGCTATGAAATATGCCTCACACTGTATAGCTCATTATAGGACGTCA

>10239_10239_9_BRE-GPN1_BRE_chr2_28152775_ENST00000379632_GPN1_chr2_27872982_ENST00000424214_length(amino acids)=97AA_BP=1
MFLFQYCAIDSCIKFWNAGSSWLSSVNFNVSPAYGMCSLNRSQLGPGVNDVQPDFKSVILKQFVASSPTFPFRTTLDMKGESIGDIRFKA

--------------------------------------------------------------
>10239_10239_10_BRE-GPN1_BRE_chr2_28152775_ENST00000379632_GPN1_chr2_27872982_ENST00000458167_length(transcript)=1075nt_BP=345nt
GGTACCTGTACCCCACGTAGTCGCCGGTTACCGATCGGACTAAGTTCCAGAAGCAAGAGATAAAGTAATAATGGGTACTGTGGGGAAAAA
CACAGAAGAACAATTCGGTAATATAGTGGTGATTTACAAGTCAAGTTAAAATGTCCCCAGAAGTGGCCTTGAACCGAATATCTCCAATGC
TCTCCCCTTTCATATCTAGCGTGGTCCGGAATGGAAAAGTGGGACTGGATGCTACAAACTGTTTGAGGATAACTGACTTAAAATCTGGCT
GCACATCATTGACTCCTGGGCCCAACTGTGACCGATTTAAACTGCACATACCATATGCTGGAGAGACATTAAAGTTTACAGAGGAAAGCC
ATGAAGAGCCAGCATTCCAGAATTTTATGCAAGAATCGATGGCACAATACTGGAAGAGAAACAATAAATAGGAGACTTTAGCACACTTCA
CTTGTTTCTAGAAGTCCAGAATTTTGGACCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGGGGCTCCCATAAGGGATAATTTTCC
TCAGAGTAGCAAAGTTTCTCTTATTAGAGAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGACCCTTGGACCTGGCAGGTTAATGCT
GATTATTCCTTGGCCTTTCCCTTGTATTTATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAAGCCTACAACTTCAAGTTTTATCAT
TTGAACTCAAGTACTTTTGCTGCTGAGGAATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCTCAGATCTCTATTATTAGGCTAGAT
GTATAGCCTCTACTCCCCCAGCTTCTTGCTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCAGCCAAGGAAAAGGGAAACATGAGC
TTATCCAGAACGGTGGCAGAGTCTCCTTGGCAATCAACCAACGTTGCTATGAAATATGCCTCACACTGTATAGCTCATTATAGGACGTCA

>10239_10239_10_BRE-GPN1_BRE_chr2_28152775_ENST00000379632_GPN1_chr2_27872982_ENST00000458167_length(amino acids)=97AA_BP=1
MFLFQYCAIDSCIKFWNAGSSWLSSVNFNVSPAYGMCSLNRSQLGPGVNDVQPDFKSVILKQFVASSPTFPFRTTLDMKGESIGDIRFKA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BRE-GPN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BRE-GPN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BRE-GPN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0026640Mouth Neoplasms1CTD_human
TgeneC0153381Malignant neoplasm of mouth1CTD_human