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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDC42BPB-SYNJ2BP (FusionGDB2 ID:HG9578TG55333)

Fusion Gene Summary for CDC42BPB-SYNJ2BP

check button Fusion gene summary
Fusion gene informationFusion gene name: CDC42BPB-SYNJ2BP
Fusion gene ID: hg9578tg55333
HgeneTgene
Gene symbol

CDC42BPB

SYNJ2BP

Gene ID

9578

55333

Gene nameCDC42 binding protein kinase betasynaptojanin 2 binding protein
SynonymsMRCKBARIP2|OMP25
Cytomap('CDC42BPB')('SYNJ2BP')

14q32.32

14q24.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase MRCK betaCDC42 binding protein kinase beta (DMPK-like)CDC42BP-betaDMPK-like betaMRCK betamyotonic dystrophy kinase-related CDC42-binding kinase betamyotonic dystrophy protein kinase-like betasynaptojanin-2-binding proteinactivin receptor interacting protein 5mitochondrial outer membrane protein 25
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000361246, 
Fusion gene scores* DoF score17 X 16 X 10=27202 X 2 X 2=8
# samples 192
** MAII scorelog2(19/2720*10)=-3.83953532780675
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: CDC42BPB [Title/Abstract] AND SYNJ2BP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDC42BPB(103414058)-SYNJ2BP(70842488), # samples:3
Anticipated loss of major functional domain due to fusion event.CDC42BPB-SYNJ2BP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDC42BPB-SYNJ2BP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDC42BPB-SYNJ2BP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDC42BPB-SYNJ2BP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDC42BPB

GO:0006468

protein phosphorylation

21949762

TgeneSYNJ2BP

GO:0070373

negative regulation of ERK1 and ERK2 cascade

24025447


check buttonFusion gene breakpoints across CDC42BPB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SYNJ2BP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-04-1365-01ACDC42BPBchr14

103414058

-SYNJ2BPchr14

70842488

-
ChimerDB4OVTCGA-04-1365-01ACDC42BPBchr14

103414058

-SYNJ2BPchr14

70847912

-


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Fusion Gene ORF analysis for CDC42BPB-SYNJ2BP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000361246ENST00000554216CDC42BPBchr14

103414058

-SYNJ2BPchr14

70842488

-
5CDS-intronENST00000361246ENST00000256366CDC42BPBchr14

103414058

-SYNJ2BPchr14

70847912

-
5CDS-intronENST00000361246ENST00000554216CDC42BPBchr14

103414058

-SYNJ2BPchr14

70847912

-
In-frameENST00000361246ENST00000256366CDC42BPBchr14

103414058

-SYNJ2BPchr14

70842488

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000361246CDC42BPBchr14103414058-ENST00000256366SYNJ2BPchr1470842488-5617382018440561290

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361246ENST00000256366CDC42BPBchr14103414058-SYNJ2BPchr1470842488-0.0022680370.9977319

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Fusion Genomic Features for CDC42BPB-SYNJ2BP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CDC42BPB-SYNJ2BP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:103414058/chr14:70842488)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDC42BPBchr14:103414058chr14:70842488ENST00000361246-2737431_81511771712.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPBchr14:103414058chr14:70842488ENST00000361246-2737878_93911771712.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPBchr14:103414058chr14:70842488ENST00000361246-2737343_41311771712.0DomainAGC-kinase C-terminal
HgeneCDC42BPBchr14:103414058chr14:70842488ENST00000361246-273776_34211771712.0DomainProtein kinase
HgeneCDC42BPBchr14:103414058chr14:70842488ENST00000361246-273782_9011771712.0Nucleotide bindingATP
HgeneCDC42BPBchr14:103414058chr14:70842488ENST00000361246-27371025_107511771712.0Zinc fingerPhorbol-ester/DAG-type
TgeneSYNJ2BPchr14:103414058chr14:70842488ENST0000025636614139_14567146.0Topological domainMitochondrial intermembrane
TgeneSYNJ2BPchr14:103414058chr14:70842488ENST0000025636614118_13867146.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDC42BPBchr14:103414058chr14:70842488ENST00000361246-27371095_121411771712.0DomainPH
HgeneCDC42BPBchr14:103414058chr14:70842488ENST00000361246-27371240_151311771712.0DomainCNH
HgeneCDC42BPBchr14:103414058chr14:70842488ENST00000361246-27371583_159611771712.0DomainCRIB
TgeneSYNJ2BPchr14:103414058chr14:70842488ENST000002563661413_10067146.0DomainPDZ
TgeneSYNJ2BPchr14:103414058chr14:70842488ENST00000256366141_11767146.0Topological domainCytoplasmic


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Fusion Gene Sequence for CDC42BPB-SYNJ2BP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>14861_14861_1_CDC42BPB-SYNJ2BP_CDC42BPB_chr14_103414058_ENST00000361246_SYNJ2BP_chr14_70842488_ENST00000256366_length(transcript)=5617nt_BP=3820nt
GGGCGGGGCTGAGGGCGGCGGGGGCGGGCCGCCCGAGCTGGGAGGGCGGCGGCGCCGAGGGGAGGAGAGCGGCCCATGGACCCGCGGGGC
CCGGCGCCCCAGACTCTGCGCCGTCGGGACGGAGCCCAAGATGTCGGCCTAGGCCGGGGCGCGACGACGCGGACGGGGCGGCGAGGAGGC
GCCGCTGCTGCCGGGGCTCGCAGCCGCCGAGCCCCCGAGGGCGCGCCCTGACGGACTGGCCGAGCCGGCGGTGAGAGGCCGGCGCGTCGG
GAGCGGGCCGCGCGGCACCATGTCGGCCAAGGTGCGGCTCAAGAAGCTGGAGCAGCTGCTCCTGGACGGGCCCTGGCGCAACGAGAGCGC
CCTGAGCGTGGAAACGCTGCTCGACGTGCTCGTCTGCCTGTACACCGAGTGCAGCCACTCGGCCCTGCGCCGCGACAAGTACGTGGCCGA
GTTCCTCGAGTGGGCTAAACCATTTACACAGCTGGTGAAAGAAATGCAGCTTCATCGAGAAGACTTTGAAATAATTAAAGTAATTGGAAG
AGGTGCTTTTGGTGAGGTTGCTGTTGTCAAAATGAAGAATACTGAACGAATTTATGCAATGAAAATCCTCAACAAGTGGGAGATGCTGAA
AAGAGCAGAGACCGCGTGCTTCCGAGAGGAGCGCGATGTGCTGGTGAACGGCGACTGCCAGTGGATCACCGCGCTGCACTACGCCTTTCA
GGACGAGAACCACCTGTACTTAGTCATGGATTACTATGTGGGTGGTGATTTACTGACCCTGCTCAGCAAATTTGAAGACAAGCTTCCGGA
AGATATGGCGAGGTTCTACATTGGTGAAATGGTGCTGGCCATTGACTCCATCCATCAGCTTCATTACGTGCACAGAGACATTAAACCTGA
CAATGTCCTTTTGGACGTGAATGGTCATATCCGCCTGGCTGACTTTGGATCATGTTTGAAGATGAATGATGATGGCACTGTGCAGTCCTC
CGTGGCCGTGGGCACACCTGACTACATCTCGCCGGAGATCCTGCAGGCGATGGAGGACGGCATGGGCAAATACGGGCCTGAGTGTGACTG
GTGGTCTCTGGGTGTCTGCATGTATGAGATGCTCTATGGAGAAACGCCGTTTTATGCGGAGTCACTCGTGGAGACCTATGGGAAGATCAT
GAACCATGAAGAGCGATTCCAGTTCCCATCCCATGTCACGGATGTATCTGAAGAAGCGAAGGACCTCATCCAGAGACTGATCTGCAGTAG
AGAACGCCGGCTGGGGCAGAATGGAATAGAGGATTTCAAAAAGCATGCGTTTTTTGAAGGTCTAAATTGGGAAAATATACGAAACCTAGA
AGCACCTTATATTCCTGATGTGAGCAGTCCCTCTGACACATCCAACTTCGACGTGGATGACGACGTGCTGAGAAACACGGAAATATTACC
TCCTGGTTCTCACACAGGCTTTTCTGGATTACATTTGCCATTCATTGGTTTTACATTCACAACGGAAAGCTGTTTTTCTGATCGAGGCTC
TCTGAAGAGCATAATGCAGTCCAACACATTAACCAAAGATGAGGATGTGCAGCGGGACCTGGAGCACAGCCTGCAGATGGAAGCTTACGA
GAGGAGGATTCGGAGGCTGGAACAGGAGAAGCTGGAGCTGAGCAGGAAGCTGCAAGAGTCCACCCAGACCGTGCAGTCCCTCCACGGCTC
ATCTCGGGCCCTCAGCAATTCAAACCGAGATAAAGAAATCAAAAAGCTAAATGAAGAAATCGAACGCTTGAAGAATAAAATAGCAGATTC
AAACAGGCTCGAGCGACAGCTTGAGGACACAGTGGCGCTTCGCCAAGAGCGTGAGGACTCCACGCAGCGGCTGCGGGGGCTGGAGAAGCA
GCACCGCGTGGTCCGGCAGGAGAAGGAGGAGCTGCACAAGCAACTGGTTGAAGCCTCAGAGCGGTTGAAATCCCAGGCCAAGGAACTCAA
AGATGCCCATCAGCAGCGAAAGCTGGCCCTGCAGGAGTTCTCGGAGCTGAACGAGCGCATGGCAGAGCTCCGTGCCCAGAAGCAGAAGGT
GTCCCGGCAGCTGCGAGACAAGGAGGAGGAGATGGAGGTGGCCACGCAGAAGGTGGACGCCATGCGGCAGGAAATGCGGAGAGCTGAGAA
GCTCAGGAAAGAGCTGGAAGCTCAGCTTGATGATGCTGTTGCTGAGGCCTCCAAGGAGCGCAAGCTTCGTGAGCACAGCGAGAACTTCTG
CAAGCAAATGGAAAGCGAGCTGGAGGCCCTCAAGGTGAAGCAAGGAGGCCGGGGAGCGGGTGCCACCTTAGAGCACCAGCAAGAGATTTC
CAAAATCAAATCCGAGCTGGAGAAGAAAGTCTTATTTTATGAAGAGGAATTGGTCAGACGTGAGGCCTCCCATGTGCTAGAAGTGAAAAA
TGTGAAGAAGGAGGTGCATGATTCAGAAAGCCACCAGCTGGCCCTGCAGAAAGAAATCTTGATGTTAAAAGATAAGTTAGAAAAGTCAAA
GCGAGAACGGCATAACGAGATGGAGGAGGCAGTAGGTACAATAAAAGATAAATACGAACGAGAAAGAGCGATGCTGTTTGATGAAAACAA
GAAGCTAACTGCTGAAAATGAAAAGCTCTGTTCCTTTGTGGATAAACTCACAGCTCAAAATAGACAGCTGGAGGATGAGCTGCAGGATCT
GGCAGCCAAGAAGGAGTCAGTGGCCCACTGGGAAGCTCAGATTGCGGAAATCATTCAGTGGGTCAGTGACGAGAAAGATGCCCGGGGTTA
CCTTCAAGCTCTTGCTTCCAAGATGACCGAAGAGCTCGAGGCTTTGAGGAGTTCTAGTCTGGGGTCAAGAACACTGGACCCGCTGTGGAA
GGTGCGCCGCAGCCAGAAGCTGGACATGTCCGCGCGGCTGGAGCTGCAGTCGGCCCTGGAGGCGGAGATCCGGGCCAAGCAGCTTGTCCA
GGAGGAGCTCAGGAAGGTCAAGGACGCCAACCTCACCTTGGAAAGCAAACTAAAGGATTCCGAAGCCAAAAACAGAGAATTATTAGAAGA
AATGGAAATTTTGAAGAAAAAGATGGAAGAAAAATTCAGAGCAGATACTGGGCTCAAACTTCCAGATTTTCAGGATTCCATTTTTGAGTA
TTTCAACACTGCTCCTCTTGCACATGACCTGACATTTAGAACCAGCTCAGCTAGTGAGCAAGAAACACAAGCTCCGAAGCCAGAAGCGTC
CCCGTCGATGTCTGTGGCTGCATCAGAGCAGCAGGAGGACATGGCTCGGCCCCCGCAGAGGCCATCCGCTGTGCCGTTGCCCACCACGCA
GGCCCTGGCTCTGGCTGGACCGAAGCCAAAAGCTCACCAGTTCAGCATCAAGTCCTTCTCCAGCCCTACTCAGTGCAGCCACTGCACCTC
CCTGATGGTTGGGCTGATCCGGCAGGGCTACGCCTGCGAGGTGTGTTCCTTTGCTTGCCACGTGTCCTGCAAAGACGGTGCCCCCCAGGT
GTGCCCAATACCTCCCGAGCAGTCCAAGAGGCCTCTGGGCGTGGACGTGCAGCGAGGCATCGGAACAGCCTACAAAGGCCATGTCAAGGT
CCCAAAGCCCACGGGGGTGAAGAAGGGATGGCAGCGCGCATATGCAGTCGTCTGTGACTGCAAGCTCTTCCTGTATGATCTGCCTGAAGG
AAAATCCACCCAGCCTGGTGTCATTGCGAGCCAAGTCTTGGATCTCAGAGATGACGAGTTTTCCGTGAGCTCAGTCCTGGCCTCAGATGT
CATTCATGCTACACGCCGAGATATTCCATGTATATTCAGGGTAAATGGCCAAGACCTAAAGAACCTGCTGCACCAGGATGCTGTAGACCT
CTTTCGTAATGCAGGCTATGCTGTGTCTCTGAGAGTGCAGCACAGGTTACAGGTGCAGAATGGACCTATAGGACATCGAGGTGAAGGGGA
CCCAAGTGGTATTCCCATATTTATGGTGCTGGTGCCAGTGTTTGCCCTCACCATGGTAGCAGCCTGGGCTTTCATGAGATACCGGCAACA
ACTTTGAAAAACTTGCTCTCTTTCAATACTCCCAATGAAGATACATTTCACTCACCCTCCACCCCTGCTATTCTGCCATGTCTTTCCCTC
TCTCTGCATAGCCAGATTTGAAGTGACTGATACCCACCCCAAACCTTGCTGTTCACAGTCTCCAATTCTTCATATTCTAATGGGAAAGTA
AAGGTATTGTTTGAAGGAAAACTGAAGAAAAGACTTGGCTTAGAACAAATGAGGAGTTATATATTTTACTAGGACTTTTGATAGAAATTC
AGCTACAACCCAAAGAGAGAAAGATTGAGTCTTCCTGTCACCATAGGCAATACCTTTTTTCTTAGCTGGCATGCCATAAAGGCCAGCTAT
GTGATATTAGAGGAAGAAAGGATTTTTCTTTTTAATGATCTTCCTTGGGAAATTATTGTGGCCTTTATTTAATTTCTAACTACGTACCTG
GGTGCCTATATCGACAAAGAGTGAGAAGAGCATTTTTACTTTTTTAAAAAAGCAAATACATATATACACATACGTATGCAAATATTATAG
TATAATAGTGATCCCTATGGAGAATTAAAGGTGAGAAAGCTACTTTGTGGTGTCTAGGTTTCTGATAAAAGGGATGATCTTAACTGAAGA
ATTTAAAGAGATACTTAAACAGAGCAAATGTAGTAGGAACAAGGGAGTGAGCCTTATAAGAGGACGTTCAGTCTCATTTATTAAAATAAT
AACTGAGACTGGGAGAGGTGGCTCATGCCTGTAAATCCCAGCACTTTGGTAGCCTGAAGTGGGAGATTGCTTGAGTCCAGGAGACCAGCC
TGGGCAACATAGCAAAACCTCATCTCTATTTAAAAAAAAAATAGAAAAAAATGTAATAACTGAAGCAACTAATTAAAAATCTTAGAAGAA
CAATATTTATTCTTATAACAGCCAACTATGGTGAGTTATTATAAGGTAAATTGCCATAATCCAGCGCTGCTCACATCTAAAAAACTTTGA
GGTGTAAAGGTAAATCGTACCAATCTCTGGGCTGCCCTAGTGACTTTTTTGATACCTCAGAGTCCTATTGAAGAACCAGGTGGAATGATT
GTGGTAAGGGCTATAGTGCTGGAGCCAAACACCCCAGCAAGAAAACTCTAAAAGGACAAAAGATAAGGTAGTGCCTCCAAGGTGGCACCT
GAACCCTCTCAGGCTACTTTTTGGTTTCTACTAACAAACCTGAGGGAAGGAACTGCCTCCCTGGCAGGATGGGCATCAAATCAACTCTGG
CTTCAGATTTAGTTAAAATGAGGCCGGGTGCAGCGGCTCACACCTGTCATCTCAGCACTTTGGGAGGCCGAGGCAGGCAGATCACAAGGT
CAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATGTCTACTGAAAATACAAAAATTACCTGGACATGGTGGCGCGTTCCTGT
AATTCCAGCTACTCAGGAGGCTGAGGCAGGAGAACTGTTTGAACCAGGACCTGGGAGACGGAGGTTGCAGTGAGCCAAGATCACGCCACT

>14861_14861_1_CDC42BPB-SYNJ2BP_CDC42BPB_chr14_103414058_ENST00000361246_SYNJ2BP_chr14_70842488_ENST00000256366_length(amino acids)=1290AA_BP=1212
MLPGLAAAEPPRARPDGLAEPAVRGRRVGSGPRGTMSAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEF
LEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQD
ENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSV
AVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLICSRE
RRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSL
KSIMQSNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSSRALSNSNRDKEIKKLNEEIERLKNKIADSN
RLERQLEDTVALRQEREDSTQRLRGLEKQHRVVRQEKEELHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERMAELRAQKQKVS
RQLRDKEEEMEVATQKVDAMRQEMRRAEKLRKELEAQLDDAVAEASKERKLREHSENFCKQMESELEALKVKQGGRGAGATLEHQQEISK
IKSELEKKVLFYEEELVRREASHVLEVKNVKKEVHDSESHQLALQKEILMLKDKLEKSKRERHNEMEEAVGTIKDKYERERAMLFDENKK
LTAENEKLCSFVDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEIIQWVSDEKDARGYLQALASKMTEELEALRSSSLGSRTLDPLWKV
RRSQKLDMSARLELQSALEAEIRAKQLVQEELRKVKDANLTLESKLKDSEAKNRELLEEMEILKKKMEEKFRADTGLKLPDFQDSIFEYF
NTAPLAHDLTFRTSSASEQETQAPKPEASPSMSVAASEQQEDMARPPQRPSAVPLPTTQALALAGPKPKAHQFSIKSFSSPTQCSHCTSL
MVGLIRQGYACEVCSFACHVSCKDGAPQVCPIPPEQSKRPLGVDVQRGIGTAYKGHVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGK
STQPGVIASQVLDLRDDEFSVSSVLASDVIHATRRDIPCIFRVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQNGPIGHRGEGDP

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Fusion Gene PPI Analysis for CDC42BPB-SYNJ2BP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDC42BPB-SYNJ2BP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDC42BPB-SYNJ2BP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDC42BPBC1535926Neurodevelopmental Disorders1CTD_human