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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ENTPD5-MICU1 (FusionGDB2 ID:HG957TG10367)

Fusion Gene Summary for ENTPD5-MICU1

check button Fusion gene summary
Fusion gene informationFusion gene name: ENTPD5-MICU1
Fusion gene ID: hg957tg10367
HgeneTgene
Gene symbol

ENTPD5

MICU1

Gene ID

957

10367

Gene nameectonucleoside triphosphate diphosphohydrolase 5 (inactive)mitochondrial calcium uptake 1
SynonymsCD39L4|NTPDase-5|PCPHCALC|CBARA1|EFHA3|MPXPS|ara CALC
Cytomap('ENTPD5')('MICU1')

14q24.3

10q22.1

Type of geneprotein-codingprotein-coding
Descriptionectonucleoside triphosphate diphosphohydrolase 5CD39 antigen-like 4CD39-like 4ER-UDPaseGDPase ENTPD5NTPDase 5Pcph proto-oncogene proteinUDPase ENTPD5guanosine-diphosphatase ENTPD5nucleoside diphosphataseproto-oncogene CPHuridine-diphosphatase Ecalcium uptake protein 1, mitochondrialatopy-related autoantigen CALCcalcium-binding atopy-related autoantigen 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000334696, ENST00000557325, 
ENST00000554664, ENST00000556242, 
Fusion gene scores* DoF score9 X 6 X 7=37822 X 15 X 11=3630
# samples 930
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(30/3630*10)=-3.59693514238723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ENTPD5 [Title/Abstract] AND MICU1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointENTPD5(74436713)-MICU1(74311099), # samples:3
Anticipated loss of major functional domain due to fusion event.ENTPD5-MICU1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ENTPD5-MICU1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ENTPD5-MICU1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ENTPD5-MICU1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ENTPD5-MICU1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ENTPD5-MICU1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMICU1

GO:0006851

mitochondrial calcium ion transmembrane transport

24560927

TgeneMICU1

GO:0051260

protein homooligomerization

24514027

TgeneMICU1

GO:0051561

positive regulation of mitochondrial calcium ion concentration

24560927

TgeneMICU1

GO:0070509

calcium ion import

20693986


check buttonFusion gene breakpoints across ENTPD5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MICU1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-DD-A4NN-01AENTPD5chr14

74436713

-MICU1chr10

74311099

-


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Fusion Gene ORF analysis for ENTPD5-MICU1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000334696ENST00000398763ENTPD5chr14

74436713

-MICU1chr10

74311099

-
5CDS-intronENST00000334696ENST00000418483ENTPD5chr14

74436713

-MICU1chr10

74311099

-
5CDS-intronENST00000334696ENST00000604025ENTPD5chr14

74436713

-MICU1chr10

74311099

-
5CDS-intronENST00000557325ENST00000398763ENTPD5chr14

74436713

-MICU1chr10

74311099

-
5CDS-intronENST00000557325ENST00000418483ENTPD5chr14

74436713

-MICU1chr10

74311099

-
5CDS-intronENST00000557325ENST00000604025ENTPD5chr14

74436713

-MICU1chr10

74311099

-
Frame-shiftENST00000334696ENST00000361114ENTPD5chr14

74436713

-MICU1chr10

74311099

-
Frame-shiftENST00000334696ENST00000398761ENTPD5chr14

74436713

-MICU1chr10

74311099

-
Frame-shiftENST00000334696ENST00000401998ENTPD5chr14

74436713

-MICU1chr10

74311099

-
In-frameENST00000557325ENST00000361114ENTPD5chr14

74436713

-MICU1chr10

74311099

-
In-frameENST00000557325ENST00000398761ENTPD5chr14

74436713

-MICU1chr10

74311099

-
In-frameENST00000557325ENST00000401998ENTPD5chr14

74436713

-MICU1chr10

74311099

-
intron-3CDSENST00000554664ENST00000361114ENTPD5chr14

74436713

-MICU1chr10

74311099

-
intron-3CDSENST00000554664ENST00000398761ENTPD5chr14

74436713

-MICU1chr10

74311099

-
intron-3CDSENST00000554664ENST00000401998ENTPD5chr14

74436713

-MICU1chr10

74311099

-
intron-3CDSENST00000556242ENST00000361114ENTPD5chr14

74436713

-MICU1chr10

74311099

-
intron-3CDSENST00000556242ENST00000398761ENTPD5chr14

74436713

-MICU1chr10

74311099

-
intron-3CDSENST00000556242ENST00000401998ENTPD5chr14

74436713

-MICU1chr10

74311099

-
intron-intronENST00000554664ENST00000398763ENTPD5chr14

74436713

-MICU1chr10

74311099

-
intron-intronENST00000554664ENST00000418483ENTPD5chr14

74436713

-MICU1chr10

74311099

-
intron-intronENST00000554664ENST00000604025ENTPD5chr14

74436713

-MICU1chr10

74311099

-
intron-intronENST00000556242ENST00000398763ENTPD5chr14

74436713

-MICU1chr10

74311099

-
intron-intronENST00000556242ENST00000418483ENTPD5chr14

74436713

-MICU1chr10

74311099

-
intron-intronENST00000556242ENST00000604025ENTPD5chr14

74436713

-MICU1chr10

74311099

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000557325ENTPD5chr1474436713-ENST00000401998MICU1chr1074311099-350815523522652766
ENST00000557325ENTPD5chr1474436713-ENST00000361114MICU1chr1074311099-350815523522652766
ENST00000557325ENTPD5chr1474436713-ENST00000398761MICU1chr1074311099-351415523522658768

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000557325ENST00000401998ENTPD5chr1474436713-MICU1chr1074311099-0.0013409280.998659
ENST00000557325ENST00000361114ENTPD5chr1474436713-MICU1chr1074311099-0.0012992880.99870074
ENST00000557325ENST00000398761ENTPD5chr1474436713-MICU1chr1074311099-0.0013680960.9986319

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Fusion Genomic Features for ENTPD5-MICU1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ENTPD5-MICU1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:74436713/chr10:74311099)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMICU1chr14:74436713chr10:74311099ENST00000361114212231_242110477.0Calcium binding1
TgeneMICU1chr14:74436713chr10:74311099ENST00000361114212421_432110477.0Calcium binding2
TgeneMICU1chr14:74436713chr10:74311099ENST0000039876309231_2420279.0Calcium binding1
TgeneMICU1chr14:74436713chr10:74311099ENST0000039876309421_4320279.0Calcium binding2
TgeneMICU1chr14:74436713chr10:74311099ENST0000041848307231_2420279.0Calcium binding1
TgeneMICU1chr14:74436713chr10:74311099ENST0000041848307421_4320279.0Calcium binding2
TgeneMICU1chr14:74436713chr10:74311099ENST00000361114212218_253110477.0DomainEF-hand 1
TgeneMICU1chr14:74436713chr10:74311099ENST00000361114212408_443110477.0DomainEF-hand 2
TgeneMICU1chr14:74436713chr10:74311099ENST0000039876309218_2530279.0DomainEF-hand 1
TgeneMICU1chr14:74436713chr10:74311099ENST0000039876309408_4430279.0DomainEF-hand 2
TgeneMICU1chr14:74436713chr10:74311099ENST0000041848307218_2530279.0DomainEF-hand 1
TgeneMICU1chr14:74436713chr10:74311099ENST0000041848307408_4430279.0DomainEF-hand 2
TgeneMICU1chr14:74436713chr10:74311099ENST00000361114212455_465110477.0RegionC-helix region
TgeneMICU1chr14:74436713chr10:74311099ENST0000039876309455_4650279.0RegionC-helix region
TgeneMICU1chr14:74436713chr10:74311099ENST000003987630999_1100279.0RegionPolybasic region
TgeneMICU1chr14:74436713chr10:74311099ENST0000041848307455_4650279.0RegionC-helix region
TgeneMICU1chr14:74436713chr10:74311099ENST000004184830799_1100279.0RegionPolybasic region
TgeneMICU1chr14:74436713chr10:74311099ENST000003987630953_4760279.0Topological domainMitochondrial intermembrane
TgeneMICU1chr14:74436713chr10:74311099ENST000004184830753_4760279.0Topological domainMitochondrial intermembrane
TgeneMICU1chr14:74436713chr10:74311099ENST000003987630934_520279.0TransmembraneHelical
TgeneMICU1chr14:74436713chr10:74311099ENST000004184830734_520279.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMICU1chr14:74436713chr10:74311099ENST0000036111421299_110110477.0RegionPolybasic region
TgeneMICU1chr14:74436713chr10:74311099ENST0000036111421253_476110477.0Topological domainMitochondrial intermembrane
TgeneMICU1chr14:74436713chr10:74311099ENST0000036111421234_52110477.0TransmembraneHelical


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Fusion Gene Sequence for ENTPD5-MICU1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>26708_26708_1_ENTPD5-MICU1_ENTPD5_chr14_74436713_ENST00000557325_MICU1_chr10_74311099_ENST00000361114_length(transcript)=3508nt_BP=1552nt
TTCCTTGTTCCTGGTCAACAAAGAAATGTGGAGTGTCTTGGCTGAATCCTCATACAGACAAGATCATTATGGTGCTGTTAGGTAGGACTT
GTATCCAGATGTAAGGTTGAAAAAGTGATATAATAAAGGAACCAAGGAGAAAATTCAGAAGGAAAGAAAAAATTGGTCTCACTCTGTCAC
CGAGGCTGGAGTACAGTGGTGCAATCACAGCTCACGGCAGCTTCAAACTCCTGGGCTCAAGCGATCCTCCTGCCTCACCCTCCCGAGTAG
CTGAGACTACAGCCTCTGCAGGTGTGCGAGCAGGATTGCTTCTGCAACAAAAGCCTCCACCCAGCCACATCTTGGGAAAAGAATGGCCAC
TTCTTGGGGCACAGTCTTTTTCATGCTGGTGGTATCCTGTGTTTGCAGCGCTGTCTCCCACAGGAACCAGCAGACTTGGTTTGAGGGTAT
CTTCCTGTCTTCCATGTGCCCCATCAATGTCAGCGCCAGCACCTTGTATGGAATTATGTTTGATGCAGGGAGCACTGGAACTCGAATTCA
TGTTTACACCTTTGTGCAGAAAATGCCAGGACAGCTTCCAATTCTAGAAGGGGAAGTTTTTGATTCTGTGAAGCCAGGACTTTCTGCTTT
TGTAGATCAACCTAAGCAGGGTGCTGAGACCGTTCAAGGGCTCTTAGAGGTGGCCAAAGACTCAATCCCCCGAAGTCACTGGAAAAAGAC
CCCAGTGGTCCTAAAGGCAACAGCAGGACTACGCTTACTGCCAGAACACAAAGCCAAGGCTCTGCTCTTTGAGGTAAAGGAGATCTTCAG
GAAGTCACCTTTCCTGGTACCAAAGGGCAGTGTTAGCATCATGGATGGATCCGACGAAGGCATATTAGCTTGGGTTACTGTGAATTTTCT
GACAGGTCAGCTGCATGGCCACAGACAGGAGACTGTGGGGACCTTGGACCTAGGGGGAGCCTCCACCCAAATCACGTTCCTGCCCCAGTT
TGAGAAAACTCTGGAACAAACTCCTAGGGGCTACCTCACTTCCTTTGAGATGTTTAACAGCACTTATAAGCTCTATACACATAGTTACCT
GGGATTTGGATTGAAAGCTGCAAGACTAGCAACCCTGGGAGCCCTGGAGACAGAAGGGACTGATGGGCACACTTTCCGGAGTGCCTGTTT
ACCGAGATGGTTGGAAGCAGAGTGGATCTTTGGGGGTGTGAAATACCAGTATGGTGGCAACCAAGAAGGGGAGGTGGGCTTTGAGCCCTG
CTATGCCGAAGTGCTGAGGGTGGTACGAGGAAAACTTCACCAGCCAGAGGAGGTCCAGAGAGGTTCCTTCTATGCTTTCTCTTACTATTA
TGACCGAGCTGTTGACACAGACATGATTGATTATGAAAAGGGGGGTATTTTAAAAGTTGAAGATTTTGAAAGAAAAGCCAGGGAAGTGTG
TGATAACTTGGAAAACTTCACCTCAGGCAGTCCTTTCCTGTGCATGGATCTCAGCTACATCACAGCCCTGTTAAAGGATGGCTTTGGCTT
TGCAGACAGCACAGTCTTACAGGTGATGGAATATGAGAATAGGATTCGAGCCTACTCCACGCCAGACAAAATCTTCCGATATTTTGCCAC
CTTGAAAGTCATCAGTGAGCCTGGTGAAGCAGAAGTGTTTATGACACCAGAAGATTTTGTGCGATCCATAACACCCAATGAAAAACAACC
AGAACACTTGGGTCTGGATCAATATATAATAAAACGCTTTGATGGAAAGAAAATTTCCCAGGAACGAGAAAAATTTGCTGATGAAGGCAG
TATATTTTACACCCTTGGAGAATGTGGGCTCATATCCTTTTCAGACTACATTTTCCTCACAACTGTTCTTTCCACTCCTCAGAGAAATTT
TGAAATTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGAAGTAGATATGGAAGAATTTGAACAGGTTCAGAGCATCATTCGCTCCCA
AACCAGTATGGGTATGCGCCACAGAGATCGTCCAACTACTGGCAACACCCTCAAGTCTGGCTTGTGTTCAGCCCTCACAACCTACTTTTT
TGGAGCTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCTCGAATTTCAGCGTAAACTGCAGCATGATGTTCTGAAGCTTGAGTTTGA
ACGCCATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTTTGGTGGCATGCTACTTGCCTACAGTGGGGTGCAGTCCAAGAAGCTGAC
CGCCATGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAAGGGTCTGACATTTCAGGAGGTGGAGAACTTCTTTACTTTCCTAAAGAA
CATTAATGATGTGGACACTGCATTGAGTTTTTACCATATGGCTGGAGCATCTCTTGATAAAGTGACCATGCAGCAGGTGGCCAGGACAGT
GGCTAAAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTTTGCACTCTTTGACTGTGATGGCAATGGCGAACTGAGCAATAAGGAATT
TGTTTCCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAAGCCCAAAGACATGGGTTTCACTCGCCTCATGCAGGCCATGTGGAAATG
TGCACAGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTAACCCCACACTGCAAGAGGGGACCCCTCCACCCCCAGTACCCTGGACCC
CCTCCGCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCTGGAAGTAGTCCCCCTTCCTCCCGGGATGACCTCAGGACTCTGTCGGTT
TCCCCTCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTCTGATTCTGCCCAATGAGTATCCCCATAGGTTCTCAAAAACATGAACAA
GTCTGTAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACCCATTCAAGCATCCTGTGGATAAAGAATTCAGGGAACCATCCACACACC
TGCCAACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCTATGGATTTATACTAACAAGAACATTCCTTGACTTCCCTCCTGCTGGTG
TTTTAAAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAGAAGTCTGTGATGATAAACAATGATGAGGATGACCTAGGCACCCTACGC
TAGTGTGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTCCCTGGGATGGCTCCAAGGCCTGCTCTAGGAAGGCAGCATGCTCAGTGG
GAACACAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGCTCTGTGCACTCCCTTTTCTTCCTCGCAGCCTCCCTAAGATGACTCCAG
TGTGACCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGTTCCCTGCAAGTGCCATTTCCTCTCCAGGATGGGCCTCTAAAGCTGAGG

>26708_26708_1_ENTPD5-MICU1_ENTPD5_chr14_74436713_ENST00000557325_MICU1_chr10_74311099_ENST00000361114_length(amino acids)=766AA_BP=398
MATSWGTVFFMLVVSCVCSAVSHRNQQTWFEGIFLSSMCPINVSASTLYGIMFDAGSTGTRIHVYTFVQKMPGQLPILEGEVFDSVKPGL
SAFVDQPKQGAETVQGLLEVAKDSIPRSHWKKTPVVLKATAGLRLLPEHKAKALLFEVKEIFRKSPFLVPKGSVSIMDGSDEGILAWVTV
NFLTGQLHGHRQETVGTLDLGGASTQITFLPQFEKTLEQTPRGYLTSFEMFNSTYKLYTHSYLGFGLKAARLATLGALETEGTDGHTFRS
ACLPRWLEAEWIFGGVKYQYGGNQEGEVGFEPCYAEVLRVVRGKLHQPEEVQRGSFYAFSYYYDRAVDTDMIDYEKGGILKVEDFERKAR
EVCDNLENFTSGSPFLCMDLSYITALLKDGFGFADSTVLQVMEYENRIRAYSTPDKIFRYFATLKVISEPGEAEVFMTPEDFVRSITPNE
KQPEHLGLDQYIIKRFDGKKISQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEVDMEEFEQVQSII
RSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFGGMLLAYSGVQSK
KLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSN

--------------------------------------------------------------
>26708_26708_2_ENTPD5-MICU1_ENTPD5_chr14_74436713_ENST00000557325_MICU1_chr10_74311099_ENST00000398761_length(transcript)=3514nt_BP=1552nt
TTCCTTGTTCCTGGTCAACAAAGAAATGTGGAGTGTCTTGGCTGAATCCTCATACAGACAAGATCATTATGGTGCTGTTAGGTAGGACTT
GTATCCAGATGTAAGGTTGAAAAAGTGATATAATAAAGGAACCAAGGAGAAAATTCAGAAGGAAAGAAAAAATTGGTCTCACTCTGTCAC
CGAGGCTGGAGTACAGTGGTGCAATCACAGCTCACGGCAGCTTCAAACTCCTGGGCTCAAGCGATCCTCCTGCCTCACCCTCCCGAGTAG
CTGAGACTACAGCCTCTGCAGGTGTGCGAGCAGGATTGCTTCTGCAACAAAAGCCTCCACCCAGCCACATCTTGGGAAAAGAATGGCCAC
TTCTTGGGGCACAGTCTTTTTCATGCTGGTGGTATCCTGTGTTTGCAGCGCTGTCTCCCACAGGAACCAGCAGACTTGGTTTGAGGGTAT
CTTCCTGTCTTCCATGTGCCCCATCAATGTCAGCGCCAGCACCTTGTATGGAATTATGTTTGATGCAGGGAGCACTGGAACTCGAATTCA
TGTTTACACCTTTGTGCAGAAAATGCCAGGACAGCTTCCAATTCTAGAAGGGGAAGTTTTTGATTCTGTGAAGCCAGGACTTTCTGCTTT
TGTAGATCAACCTAAGCAGGGTGCTGAGACCGTTCAAGGGCTCTTAGAGGTGGCCAAAGACTCAATCCCCCGAAGTCACTGGAAAAAGAC
CCCAGTGGTCCTAAAGGCAACAGCAGGACTACGCTTACTGCCAGAACACAAAGCCAAGGCTCTGCTCTTTGAGGTAAAGGAGATCTTCAG
GAAGTCACCTTTCCTGGTACCAAAGGGCAGTGTTAGCATCATGGATGGATCCGACGAAGGCATATTAGCTTGGGTTACTGTGAATTTTCT
GACAGGTCAGCTGCATGGCCACAGACAGGAGACTGTGGGGACCTTGGACCTAGGGGGAGCCTCCACCCAAATCACGTTCCTGCCCCAGTT
TGAGAAAACTCTGGAACAAACTCCTAGGGGCTACCTCACTTCCTTTGAGATGTTTAACAGCACTTATAAGCTCTATACACATAGTTACCT
GGGATTTGGATTGAAAGCTGCAAGACTAGCAACCCTGGGAGCCCTGGAGACAGAAGGGACTGATGGGCACACTTTCCGGAGTGCCTGTTT
ACCGAGATGGTTGGAAGCAGAGTGGATCTTTGGGGGTGTGAAATACCAGTATGGTGGCAACCAAGAAGGGGAGGTGGGCTTTGAGCCCTG
CTATGCCGAAGTGCTGAGGGTGGTACGAGGAAAACTTCACCAGCCAGAGGAGGTCCAGAGAGGTTCCTTCTATGCTTTCTCTTACTATTA
TGACCGAGCTGTTGACACAGACATGATTGATTATGAAAAGGGGGGTATTTTAAAAGTTGAAGATTTTGAAAGAAAAGCCAGGGAAGTGTG
TGATAACTTGGAAAACTTCACCTCAGGCAGTCCTTTCCTGTGCATGGATCTCAGCTACATCACAGCCCTGTTAAAGGATGGCTTTGGCTT
TGCAGACAGCACAGTCTTACAGGTGATGGAATATGAGAATAGGATTCGAGCCTACTCCACGCCAGACAAAATCTTCCGATATTTTGCCAC
CTTGAAAGTCATCAGTGAGCCTGGTGAAGCAGAAGTGTTTATGACACCAGAAGATTTTGTGCGATCCATAACACCCAATGAAAAACAACC
AGAACACTTGGGTCTGGATCAATATATAATAAAACGCTTTGATGGAAAGAATAAGAAAATTTCCCAGGAACGAGAAAAATTTGCTGATGA
AGGCAGTATATTTTACACCCTTGGAGAATGTGGGCTCATATCCTTTTCAGACTACATTTTCCTCACAACTGTTCTTTCCACTCCTCAGAG
AAATTTTGAAATTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGAAGTAGATATGGAAGAATTTGAACAGGCAATTAGCATCATTCG
CTCCCAAACCAGTATGGGTATGCGCCACAGAGATCGTCCAACTACTGGCAACACCCTCAAGTCTGGCTTGTGTTCAGCCCTCACAACCTA
CTTTTTTGGAGCTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCTCGAATTTCAGCGTAAACTGCAGCATGATGTTCTGAAGCTTGA
GTTTGAACGCCATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTTTGGTGGCATGCTACTTGCCTACAGTGGGGTGCAGTCCAAGAA
GCTGACCGCCATGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAAGGGTCTGACATTTCAGGAGGTGGAGAACTTCTTTACTTTCCT
AAAGAACATTAATGATGTGGACACTGCATTGAGTTTTTACCATATGGCTGGAGCATCTCTTGATAAAGTGACCATGCAGCAGGTGGCCAG
GACAGTGGCTAAAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTTTGCACTCTTTGACTGTGATGGCAATGGCGAACTGAGCAATAA
GGAATTTGTTTCCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAAGCCCAAAGACATGGGTTTCACTCGCCTCATGCAGGCCATGTG
GAAATGTGCACAGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTAACCCCACACTGCAAGAGGGGACCCCTCCACCCCCAGTACCCT
GGACCCCCTCCGCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCTGGAAGTAGTCCCCCTTCCTCCCGGGATGACCTCAGGACTCTG
TCGGTTTCCCCTCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTCTGATTCTGCCCAATGAGTATCCCCATAGGTTCTCAAAAACAT
GAACAAGTCTGTAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACCCATTCAAGCATCCTGTGGATAAAGAATTCAGGGAACCATCCA
CACACCTGCCAACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCTATGGATTTATACTAACAAGAACATTCCTTGACTTCCCTCCTG
CTGGTGTTTTAAAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAGAAGTCTGTGATGATAAACAATGATGAGGATGACCTAGGCACC
CTACGCTAGTGTGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTCCCTGGGATGGCTCCAAGGCCTGCTCTAGGAAGGCAGCATGCT
CAGTGGGAACACAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGCTCTGTGCACTCCCTTTTCTTCCTCGCAGCCTCCCTAAGATGA
CTCCAGTGTGACCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGTTCCCTGCAAGTGCCATTTCCTCTCCAGGATGGGCCTCTAAAG
CTGAGGCCTGGCTCAGAGCCTGTTTGCCCTCTGTCTTAAACAATTGTAAATATCACTTAAATTATAACCATTTGCAATAAACATCCCCAA

>26708_26708_2_ENTPD5-MICU1_ENTPD5_chr14_74436713_ENST00000557325_MICU1_chr10_74311099_ENST00000398761_length(amino acids)=768AA_BP=398
MATSWGTVFFMLVVSCVCSAVSHRNQQTWFEGIFLSSMCPINVSASTLYGIMFDAGSTGTRIHVYTFVQKMPGQLPILEGEVFDSVKPGL
SAFVDQPKQGAETVQGLLEVAKDSIPRSHWKKTPVVLKATAGLRLLPEHKAKALLFEVKEIFRKSPFLVPKGSVSIMDGSDEGILAWVTV
NFLTGQLHGHRQETVGTLDLGGASTQITFLPQFEKTLEQTPRGYLTSFEMFNSTYKLYTHSYLGFGLKAARLATLGALETEGTDGHTFRS
ACLPRWLEAEWIFGGVKYQYGGNQEGEVGFEPCYAEVLRVVRGKLHQPEEVQRGSFYAFSYYYDRAVDTDMIDYEKGGILKVEDFERKAR
EVCDNLENFTSGSPFLCMDLSYITALLKDGFGFADSTVLQVMEYENRIRAYSTPDKIFRYFATLKVISEPGEAEVFMTPEDFVRSITPNE
KQPEHLGLDQYIIKRFDGKNKKISQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEVDMEEFEQAIS
IIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFGGMLLAYSGVQ
SKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGEL

--------------------------------------------------------------
>26708_26708_3_ENTPD5-MICU1_ENTPD5_chr14_74436713_ENST00000557325_MICU1_chr10_74311099_ENST00000401998_length(transcript)=3508nt_BP=1552nt
TTCCTTGTTCCTGGTCAACAAAGAAATGTGGAGTGTCTTGGCTGAATCCTCATACAGACAAGATCATTATGGTGCTGTTAGGTAGGACTT
GTATCCAGATGTAAGGTTGAAAAAGTGATATAATAAAGGAACCAAGGAGAAAATTCAGAAGGAAAGAAAAAATTGGTCTCACTCTGTCAC
CGAGGCTGGAGTACAGTGGTGCAATCACAGCTCACGGCAGCTTCAAACTCCTGGGCTCAAGCGATCCTCCTGCCTCACCCTCCCGAGTAG
CTGAGACTACAGCCTCTGCAGGTGTGCGAGCAGGATTGCTTCTGCAACAAAAGCCTCCACCCAGCCACATCTTGGGAAAAGAATGGCCAC
TTCTTGGGGCACAGTCTTTTTCATGCTGGTGGTATCCTGTGTTTGCAGCGCTGTCTCCCACAGGAACCAGCAGACTTGGTTTGAGGGTAT
CTTCCTGTCTTCCATGTGCCCCATCAATGTCAGCGCCAGCACCTTGTATGGAATTATGTTTGATGCAGGGAGCACTGGAACTCGAATTCA
TGTTTACACCTTTGTGCAGAAAATGCCAGGACAGCTTCCAATTCTAGAAGGGGAAGTTTTTGATTCTGTGAAGCCAGGACTTTCTGCTTT
TGTAGATCAACCTAAGCAGGGTGCTGAGACCGTTCAAGGGCTCTTAGAGGTGGCCAAAGACTCAATCCCCCGAAGTCACTGGAAAAAGAC
CCCAGTGGTCCTAAAGGCAACAGCAGGACTACGCTTACTGCCAGAACACAAAGCCAAGGCTCTGCTCTTTGAGGTAAAGGAGATCTTCAG
GAAGTCACCTTTCCTGGTACCAAAGGGCAGTGTTAGCATCATGGATGGATCCGACGAAGGCATATTAGCTTGGGTTACTGTGAATTTTCT
GACAGGTCAGCTGCATGGCCACAGACAGGAGACTGTGGGGACCTTGGACCTAGGGGGAGCCTCCACCCAAATCACGTTCCTGCCCCAGTT
TGAGAAAACTCTGGAACAAACTCCTAGGGGCTACCTCACTTCCTTTGAGATGTTTAACAGCACTTATAAGCTCTATACACATAGTTACCT
GGGATTTGGATTGAAAGCTGCAAGACTAGCAACCCTGGGAGCCCTGGAGACAGAAGGGACTGATGGGCACACTTTCCGGAGTGCCTGTTT
ACCGAGATGGTTGGAAGCAGAGTGGATCTTTGGGGGTGTGAAATACCAGTATGGTGGCAACCAAGAAGGGGAGGTGGGCTTTGAGCCCTG
CTATGCCGAAGTGCTGAGGGTGGTACGAGGAAAACTTCACCAGCCAGAGGAGGTCCAGAGAGGTTCCTTCTATGCTTTCTCTTACTATTA
TGACCGAGCTGTTGACACAGACATGATTGATTATGAAAAGGGGGGTATTTTAAAAGTTGAAGATTTTGAAAGAAAAGCCAGGGAAGTGTG
TGATAACTTGGAAAACTTCACCTCAGGCAGTCCTTTCCTGTGCATGGATCTCAGCTACATCACAGCCCTGTTAAAGGATGGCTTTGGCTT
TGCAGACAGCACAGTCTTACAGGTGATGGAATATGAGAATAGGATTCGAGCCTACTCCACGCCAGACAAAATCTTCCGATATTTTGCCAC
CTTGAAAGTCATCAGTGAGCCTGGTGAAGCAGAAGTGTTTATGACACCAGAAGATTTTGTGCGATCCATAACACCCAATGAAAAACAACC
AGAACACTTGGGTCTGGATCAATATATAATAAAACGCTTTGATGGAAAGAAAATTTCCCAGGAACGAGAAAAATTTGCTGATGAAGGCAG
TATATTTTACACCCTTGGAGAATGTGGGCTCATATCCTTTTCAGACTACATTTTCCTCACAACTGTTCTTTCCACTCCTCAGAGAAATTT
TGAAATTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGAAGTAGATATGGAAGAATTTGAACAGGCAATTAGCATCATTCGCTCCCA
AACCAGTATGGGTATGCGCCACAGAGATCGTCCAACTACTGGCAACACCCTCAAGTCTGGCTTGTGTTCAGCCCTCACAACCTACTTTTT
TGGAGCTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCTCGAATTTCAGCGTAAACTGCAGCATGATGTTCTGAAGCTTGAGTTTGA
ACGCCATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTTTGGTGGCATGCTACTTGCCTACAGTGGGGTGCAGTCCAAGAAGCTGAC
CGCCATGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAAGGGTCTGACATTTCAGGAGGTGGAGAACTTCTTTACTTTCCTAAAGAA
CATTAATGATGTGGACACTGCATTGAGTTTTTACCATATGGCTGGAGCATCTCTTGATAAAGTGACCATGCAGCAGGTGGCCAGGACAGT
GGCTAAAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTTTGCACTCTTTGACTGTGATGGCAATGGCGAACTGAGCAATAAGGAATT
TGTTTCCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAAGCCCAAAGACATGGGTTTCACTCGCCTCATGCAGGCCATGTGGAAATG
TGCACAGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTAACCCCACACTGCAAGAGGGGACCCCTCCACCCCCAGTACCCTGGACCC
CCTCCGCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCTGGAAGTAGTCCCCCTTCCTCCCGGGATGACCTCAGGACTCTGTCGGTT
TCCCCTCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTCTGATTCTGCCCAATGAGTATCCCCATAGGTTCTCAAAAACATGAACAA
GTCTGTAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACCCATTCAAGCATCCTGTGGATAAAGAATTCAGGGAACCATCCACACACC
TGCCAACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCTATGGATTTATACTAACAAGAACATTCCTTGACTTCCCTCCTGCTGGTG
TTTTAAAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAGAAGTCTGTGATGATAAACAATGATGAGGATGACCTAGGCACCCTACGC
TAGTGTGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTCCCTGGGATGGCTCCAAGGCCTGCTCTAGGAAGGCAGCATGCTCAGTGG
GAACACAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGCTCTGTGCACTCCCTTTTCTTCCTCGCAGCCTCCCTAAGATGACTCCAG
TGTGACCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGTTCCCTGCAAGTGCCATTTCCTCTCCAGGATGGGCCTCTAAAGCTGAGG

>26708_26708_3_ENTPD5-MICU1_ENTPD5_chr14_74436713_ENST00000557325_MICU1_chr10_74311099_ENST00000401998_length(amino acids)=766AA_BP=398
MATSWGTVFFMLVVSCVCSAVSHRNQQTWFEGIFLSSMCPINVSASTLYGIMFDAGSTGTRIHVYTFVQKMPGQLPILEGEVFDSVKPGL
SAFVDQPKQGAETVQGLLEVAKDSIPRSHWKKTPVVLKATAGLRLLPEHKAKALLFEVKEIFRKSPFLVPKGSVSIMDGSDEGILAWVTV
NFLTGQLHGHRQETVGTLDLGGASTQITFLPQFEKTLEQTPRGYLTSFEMFNSTYKLYTHSYLGFGLKAARLATLGALETEGTDGHTFRS
ACLPRWLEAEWIFGGVKYQYGGNQEGEVGFEPCYAEVLRVVRGKLHQPEEVQRGSFYAFSYYYDRAVDTDMIDYEKGGILKVEDFERKAR
EVCDNLENFTSGSPFLCMDLSYITALLKDGFGFADSTVLQVMEYENRIRAYSTPDKIFRYFATLKVISEPGEAEVFMTPEDFVRSITPNE
KQPEHLGLDQYIIKRFDGKKISQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEVDMEEFEQAISII
RSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFGGMLLAYSGVQSK
KLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ENTPD5-MICU1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ENTPD5-MICU1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ENTPD5-MICU1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC3810285MYOPATHY WITH EXTRAPYRAMIDAL SIGNS2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0004782Basal Ganglia Diseases1CTD_human
TgeneC0015371Extrapyramidal Disorders1CTD_human
TgeneC0023186Learning Disorders1CTD_human
TgeneC0026650Movement Disorders1CTD_human
TgeneC0026848Myopathy1CTD_human
TgeneC0266487Etat Marbre1CTD_human
TgeneC0750951Lenticulostriate Disorders1CTD_human
TgeneC0751262Adult Learning Disorders1CTD_human
TgeneC0751263Learning Disturbance1CTD_human
TgeneC0751265Learning Disabilities1CTD_human
TgeneC1330966Developmental Academic Disorder1CTD_human