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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NCOR1-CDRT4 (FusionGDB2 ID:HG9611TG284040)

Fusion Gene Summary for NCOR1-CDRT4

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOR1-CDRT4
Fusion gene ID: hg9611tg284040
HgeneTgene
Gene symbol

NCOR1

CDRT4

Gene ID

9611

284040

Gene namenuclear receptor corepressor 1CMT1A duplicated region transcript 4
SynonymsN-CoR|N-CoR1|PPP1R109|TRAC1|hN-CoR-
Cytomap('NCOR1')('CDRT4')

17p12-p11.2

17p12

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor corepressor 1protein phosphatase 1, regulatory subunit 109thyroid hormone- and retinoic acid receptor-associated corepressor 1CMT1A duplicated region transcript 4 protein
Modification date2020031320200327
UniProtAcc.

Q8N9R6

Ensembl transtripts involved in fusion geneENST00000268712, ENST00000395851, 
ENST00000395848, ENST00000395857, 
ENST00000583226, 
Fusion gene scores* DoF score30 X 30 X 13=117005 X 2 X 5=50
# samples 336
** MAII scorelog2(33/11700*10)=-5.14789869511231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/50*10)=0.263034405833794
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NCOR1 [Title/Abstract] AND CDRT4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNCOR1(15989596)-CDRT4(15343599), # samples:2
Anticipated loss of major functional domain due to fusion event.NCOR1-CDRT4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOR1-CDRT4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOR1-CDRT4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOR1-CDRT4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOR1-CDRT4 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NCOR1-CDRT4 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NCOR1-CDRT4 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCOR1

GO:0046329

negative regulation of JNK cascade

11931768


check buttonFusion gene breakpoints across NCOR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CDRT4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-E5-A2PC-01ANCOR1chr17

15989596

-CDRT4chr17

15341517

-
ChimerDB4BLCATCGA-E5-A2PC-01ANCOR1chr17

15989596

-CDRT4chr17

15343599

-


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Fusion Gene ORF analysis for NCOR1-CDRT4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000268712ENST00000312177NCOR1chr17

15989596

-CDRT4chr17

15343599

-
5CDS-5UTRENST00000268712ENST00000519354NCOR1chr17

15989596

-CDRT4chr17

15341517

-
5CDS-5UTRENST00000395851ENST00000312177NCOR1chr17

15989596

-CDRT4chr17

15343599

-
5CDS-5UTRENST00000395851ENST00000519354NCOR1chr17

15989596

-CDRT4chr17

15341517

-
5CDS-intronENST00000268712ENST00000519354NCOR1chr17

15989596

-CDRT4chr17

15343599

-
5CDS-intronENST00000395851ENST00000519354NCOR1chr17

15989596

-CDRT4chr17

15343599

-
Frame-shiftENST00000395851ENST00000312177NCOR1chr17

15989596

-CDRT4chr17

15341517

-
In-frameENST00000268712ENST00000312177NCOR1chr17

15989596

-CDRT4chr17

15341517

-
intron-3CDSENST00000395848ENST00000312177NCOR1chr17

15989596

-CDRT4chr17

15341517

-
intron-3CDSENST00000395857ENST00000312177NCOR1chr17

15989596

-CDRT4chr17

15341517

-
intron-3CDSENST00000583226ENST00000312177NCOR1chr17

15989596

-CDRT4chr17

15341517

-
intron-5UTRENST00000395848ENST00000312177NCOR1chr17

15989596

-CDRT4chr17

15343599

-
intron-5UTRENST00000395848ENST00000519354NCOR1chr17

15989596

-CDRT4chr17

15341517

-
intron-5UTRENST00000395857ENST00000312177NCOR1chr17

15989596

-CDRT4chr17

15343599

-
intron-5UTRENST00000395857ENST00000519354NCOR1chr17

15989596

-CDRT4chr17

15341517

-
intron-5UTRENST00000583226ENST00000312177NCOR1chr17

15989596

-CDRT4chr17

15343599

-
intron-5UTRENST00000583226ENST00000519354NCOR1chr17

15989596

-CDRT4chr17

15341517

-
intron-intronENST00000395848ENST00000519354NCOR1chr17

15989596

-CDRT4chr17

15343599

-
intron-intronENST00000395857ENST00000519354NCOR1chr17

15989596

-CDRT4chr17

15343599

-
intron-intronENST00000583226ENST00000519354NCOR1chr17

15989596

-CDRT4chr17

15343599

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000268712NCOR1chr1715989596-ENST00000312177CDRT4chr1715341517-5621343523435241096

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000268712ENST00000312177NCOR1chr1715989596-CDRT4chr1715341517-0.0013325640.9986675

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Fusion Genomic Features for NCOR1-CDRT4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for NCOR1-CDRT4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:15989596/chr17:15343599)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CDRT4

Q8N9R6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-2346174_21610592441.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-2346299_32810592441.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-2346501_55710592441.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-2245174_21610752338.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-2245299_32810752338.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-2245501_55710752338.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-23461032_103510592441.0Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-234658_6410592441.0Compositional biasNote=Poly-Gln
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-2346593_60310592441.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-2346607_61710592441.0Compositional biasNote=Pro-rich
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-22451032_103510752338.0Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-224558_6410752338.0Compositional biasNote=Poly-Gln
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-2245593_60310752338.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-2245607_61710752338.0Compositional biasNote=Pro-rich
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-2346435_48610592441.0DomainSANT 1
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-2346623_67410592441.0DomainSANT 2
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-2245435_48610752338.0DomainSANT 1
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-2245623_67410752338.0DomainSANT 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-119174_2160915.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-119299_3280915.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-119501_5570915.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-23461707_171210592441.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-23461952_196310592441.0Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-1191032_10350915.0Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-1191707_17120915.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-1191952_19630915.0Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-11958_640915.0Compositional biasNote=Poly-Gln
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-119593_6030915.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-119607_6170915.0Compositional biasNote=Pro-rich
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-22451707_171210752338.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-22451952_196310752338.0Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-119435_4860915.0DomainSANT 1
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-119623_6740915.0DomainSANT 2
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-23461933_193710592441.0MotifNote=CORNR box 1
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-23462055_205910592441.0MotifNote=CORNR box 2
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-23462263_226710592441.0MotifNote=CORNR box 3
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-1191933_19370915.0MotifNote=CORNR box 1
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-1192055_20590915.0MotifNote=CORNR box 2
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-1192263_22670915.0MotifNote=CORNR box 3
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-22451933_193710752338.0MotifNote=CORNR box 1
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-22452055_205910752338.0MotifNote=CORNR box 2
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-22452263_226710752338.0MotifNote=CORNR box 3
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-23462032_211510592441.0RegionID1
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-23462212_227310592441.0RegionID2
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-1192032_21150915.0RegionID1
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-1192212_22730915.0RegionID2
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-22452032_211510752338.0RegionID1
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-22452212_227310752338.0RegionID2


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Fusion Gene Sequence for NCOR1-CDRT4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57828_57828_1_NCOR1-CDRT4_NCOR1_chr17_15989596_ENST00000268712_CDRT4_chr17_15341517_ENST00000312177_length(transcript)=5621nt_BP=3435nt
GGAGGGAGAGGGGTTGAGTCAAGATGGCGGCCAAGGTGGCGAAGCAGCAGCCGCGGCGGCGGCGGCGGCTGGAGTGAGCGTCCGACTCGC
CGCGCCGAACGAGGTCCCGGTGTAGGGCCGCGCGCCGTGGCCGCGTCCCACTCCTCAGGCCGGGGCGCACGTCGGCTCCCACGCTTAGCC
AGCTCCCGGTGGTTTCCTAGAAACATGATTGTTTATTGGCATTGATCTCACAGTCTGGTGAGGACTTCTTTACTGATAATGTCAAGTTCA
GGTTATCCTCCCAACCAAGGAGCATTCAGCACAGAACAAAGTCGTTATCCTCCTCACTCTGTCCAGTATACATTTCCCAACACCCGCCAC
CAGCAGGAGTTCGCAGTCCCTGATTATCGTTCCTCTCATCTTGAAGTGAGTCAGGCATCACAGCTTTTGCAGCAACAGCAGCAGCAACAG
CTTCGAAGGCGACCTTCCTTGCTTTCAGAATTTCACCCAGGTTCTGACAGGCCTCAAGAAAGGAGAACTAGTTATGAACCGTTTCATCCA
GGCCCATCCCCAGTGGATCATGATTCACTGGAATCGAAGCGACCACGTCTGGAACAGGTTTCTGATTCTCATTTTCAGCGTGTCAGTGCT
GCGGTTTTGCCTTTAGTGCACCCGCTGCCAGAAGGGCTGAGGGCTTCTGCAGATGCTAAGAAGGATCCAGCATTCGGAGGCAAACATGAA
GCTCCATCCTCTCCAATTTCGGGGCAACCATGTGGAGATGATCAAAATGCTTCACCTTCAAAACTCTCAAAGGAAGAGTTAATACAGAGT
ATGGATCGTGTAGATCGAGAAATTGCAAAAGTAGAACAGCAGATCCTTAAACTGAAAAAGAAACAACAACAGCTTGAAGAAGAGGCAGCT
AAACCTCCTGAGCCTGAGAAGCCCGTGTCCCCTCCTCCTGTGGAGCAGAAACACCGCAGTATTGTCCAAATTATTTATGATGAGAATCGG
AAAAAAGCAGAAGAAGCTCATAAAATTTTTGAAGGTCTTGGCCCAAAAGTTGAACTGCCACTGTATAACCAGCCATCAGATACCAAGGTG
TACCATGAGAACATCAAGACAAACCAGGTGATGAGGAAAAAACTCATTTTATTTTTTAAAAGAAGAAATCATGCAAGAAAACAAAGGGAA
CAAAAAATCTGCCAGCGTTATGATCAGCTCATGGAGGCATGGGAGAAAAAAGTGGACAGAATAGAAAATAATCCTCGGAGGAAAGCTAAA
GAAAGCAAAACAAGGGAATACTATGAAAAGCAGTTTCCAGAAATTCGAAAACAAAGAGAACAGCAAGAAAGATTTCAGCGAGTTGGGCAG
AGGGGAGCTGGTCTTTCAGCCACCATTGCTAGGAGTGAGCATGAGATTTCTGAAATTATTGATGGGCTCTCTGAGCAGGAGAATAATGAG
AAACAAATGCGGCAGCTCTCTGTGATTCCACCTATGATGTTTGATGCAGAACAAAGACGAGTCAAGTTCATTAACATGAATGGGCTTATG
GAGGACCCTATGAAAGTGTATAAAGATAGGCAGTTTATGAATGTTTGGACTGACCATGAAAAGGAGATCTTTAAGGACAAGTTTATCCAG
CATCCAAAAAACTTTGGACTAATTGCATCATACTTGGAGAGGAAGAGTGTTCCTGATTGTGTTTTGTATTACTATTTAACCAAGAAAAAT
GAGAATTATAAAGCCCTCGTCAGAAGGAATTATGGGAAACGCAGAGGCAGAAACCAGCAAATTGCTCGACCCTCGCAAGAAGAAAAAGTA
GAAGAAAAAGAAGAGGATAAAGCAGAAAAAACAGAAAAAAAAGAAGAAGAAAAGAAAGATGAAGAGGAAAAAGATGAAAAAGAAGACTCC
AAAGAAAATACCAAGGAAAAGGACAAGATAGATGGTACAGCAGAAGAAACTGAGGAAAGAGAGCAAGCCACACCCCGGGGGCGAAAGACT
GCCAACAGTCAGGGCCGCCGTAAGGGCCGGATCACCAGGTCCATGACAAACGAAGCTGCAGCTGCCAGTGCTGCAGCCGCAGCGGCTACT
GAAGAGCCCCCACCACCTCTGCCACCGCCACCAGAACCCATTTCTACAGAGCCTGTGGAGACCTCTCGATGGACAGAAGAAGAAATGGAA
GTTGCTAAAAAAGGTCTAGTAGAACATGGTCGTAACTGGGCAGCAATTGCTAAAATGGTGGGAACGAAAAGTGAAGCTCAATGTAAAAAC
TTCTATTTTAACTATAAAAGGCGACACAATCTTGACAACCTCTTACAGCAGCATAAACAGAAAACTTCACGAAAACCTCGTGAAGAGCGA
GATGTGTCTCAATGTGAAAGTGTCGCTTCCACTGTTTCTGCTCAGGAGGATGAAGATATTGAAGCCTCCAATGAAGAAGAAAATCCAGAA
GACAGCGAAGTTGAAGCTGTCAAGCCCAGCGAGGACAGTCCTGAAAATGCTACTTCTCGAGGAAACACAGAACCTGCGGTTGAGCTTGAG
CCCACCACGGAAACTGCACCCAGTACATCTCCCTCCTTAGCAGTTCCAAGTACAAAACCAGCTGAAGATGAAAGTGTGGAGACCCAGGTG
AATGACAGCATCAGTGCTGAGACAGCAGAGCAGATGGATGTAGATCAGCAGGAGCACAGTGCTGAAGAGGGTTCTGTTTGTGATCCCCCA
CCCGCTACCAAAGCTGACTCTGTGGACGTTGAAGTGAGGGTGCCAGAAAACCATGCATCTAAAGTTGAAGGTGATAATACCAAAGAAAGA
GACTTGGATAGAGCCAGTGAGAAGGTGGAACCTAGAGATGAAGATTTGGTGGTAGCTCAGCAAATAAATGCCCAAAGGCCCGAGCCCCAG
TCAGACAATGATTCCAGTGCCACGTGCAGCGCTGATGAGGATGTGGATGGAGAGCCAGAGAGGCAGAGAATGTTTCCTATGGACTCAAAG
CCTTCACTGTTAAACCCCACTGGATCTATACTCGTCTCATCTCCGTTAAAACCAAATCCACTGGATCTGCCACAGCTTCAGCATCGAGCT
GCTGTTATCCCACCAATGGTATCCTGCACCCCATGTAACATACCAATTGGAACCCCAGTGAGCGGCTATGCTCTCTACCAGCGACACATT
AAAGCAATGCATGAGTCAGCACTCCTGGAGGAGCAGCGGCAGAGACAAGAACAGATAGATTTGGAATGTAGAAGTTCTACAAGTCCATGT
GGCACATCCAAGAGTCCAAACAGAGAGTGGGAAGTCCTTCAGCCTGCTCCACATCAAGTGATAACTAATCTCCCTGAAGGCGTTCGGCTT
CCGACAACTCGACCAACCAGGCCACCGCCCCCTCTCATCCCGTCATCCAAAACCACAGTGGCTTCAGAAAAACCATCTTTTATAATGGGA
GGCTCCATCTCACAGGACTCACAGAAAACACTGGACTTCCCCGGAAGCTACTTGAAAAACATGACCCCTGGCCGGCCTATGTCACCTATA
CCTCTCAGACAGTGAAAAGACTCATTGAGAAAAGCAAAACTAGAGAACTGGAATGCATGCGTGCCCTCGAGGAAAGACCCTGGGCATCAA
GGCAGAATAAACCTTCCAGCGTCATTCAGCCGAAAAGGAGGAAGTCTTCCAAGTCTTCTGGCAAAGCTGTGTTCAGGGACACGCTGTCAG
AATCCACGTTATCAATGTGGGGCGCTTATTCGGTATTGGCCATGGCTCCTACCATGATCCCAGAACCCACACACTTACATGCGGATTCCA
GAGACTGTCCAACTGAAAACTATAACAAGATCATCTTTGCCCGCAAGCCTATGATGAGGATGCTCCCTACAGTTCGCTACTGACCAACAA
GGAGAAACATGCAAATGTTTTAGCCAGGGGTCCCTGCAGCCATTCCCCAAGAACGTACAAAAGTTAAGCTCCATTTACCACTCACTTGAC
AGTGTCCTTTAAATCTGAACTTGCTCTTGCTCATGCGGAGCTTGGCTAAGAGAAACCAGATCAGAATGCAAGCTGTAGGTGGGTGGGTGA
GTGTGTCCCCTCCCACACTGCTCTCTGGTGGGTTTGGGCAGTCCCTGGCTCTAGTCTCTGCTGCAGATTCTCAGGACCAAAATGTGGGTG
ATTTGTCTGGGTCCAGGCAGGAGACAGAAATCACACAAGCTCTTTTATTAGAGATAATATAAAGAATGATTAACCAGGTGACAGTAAAGG
GCAGGAAGGGAATACAAAGGTATCCATGGAGGTAGCACCACAGGAAGCAGGCATCACACTTGAGGCTTGGGAACAAGGGGAAGATGCTGG
ACTCATTGAAAGGTGGTTGCTTGGAGAAGGGACATGGGGCTGAATCTCAGACTTCTGAGGTGGGGGAGTGGGGATGCCACTCAATGCAGC
TGGTATCTCTGAGCTCTGAGGAGAGTCCTGTGGGGATGGTGCCCCCTCCTCTGAATAGGGGAGATGTTTTGTTGGTGTCTCTGAGGGGAC
CCCCATGAGGCTGCTTTTGTGAGTGTTGGAAAAACCAAAAACTGCATTGAAATGTTTCTGGGAGGAGTTGCCACTGCCTGGGTGAAGAAA
AAGCACTGCTAGGGTTAGCAACCTGTCTGGCAAGGGACAGGAAGCTGATAGAAAGTGAACAGGAAGCAAACAGGAAGTGAGCAAGGGGCC
ACTTCCTACTTCCTCCTTTAGCCTAGCAGATTCCTTCTAGCTCCCCCTGGGGGCTGAGCCTATCAGGGCACAAAGCCAGAATGTGGTTTG
TAGAATCCCAGCCCCAGCATCTCCAAGCATAGGATGGATTTTGAAGCCAAGAGGGAATTAGCTCTCGGCCGGGTTCTGAGTGATCCCATC
CAGCTGCTCCTGGACCTGGTATTGAGAGGTTTTTCCCTTGGAGGGCAAACAAAGTGGCAGTGGGGACCAGGGTGTCCCCTGCTGAGAAAT
GGAGAGCTCTTTTCCCCTGTACTTCTCTGGGGTTTGCCTTGTGGAACCAAGTGCTTGGGGGAGGAGCTCCTGGCAGGACTCCAGCTGTTA
TTTGTCAGAGGACAGCTAGGATTGGTTCACCCTTGCTCTGAGTTGGCCCCAAAGCGAGCTATGCTGAACTCTTCTCCATCTCCAAGCAGA
CAACCTTTGTCTTTACATGCAAGAGGGATCCAATTATGACAGGCTGACCCAGCTGGTTTCATGTTTGGGGTTTATCTACTGAGTAAGGCT
GACCTTACCTGAGTTTCTGTATGTGTATTTGCAAGACAGTTAATACTAATCCATCATCCCTCACAGAGATGTAGAGGATGAGATGTAGTA
ACTTATAGCAGTGTCATTTGGAAAAGTTGAATTTGCCCTACAAGGCATGTTCTCCATTCAAGGGTCTTGTGTAAACGTTTGCAGACACAG
GTGCAGCTTTGGAGAACTCACCTCTGGCTCTTGTGCTTTTATGTTGGGACAGCTGCCTAAATTAGGAGCTCTAGACCTGTTATTGGTTCC
CAACTGTTGGCCAGAATGAATTCTTCGAAAAATATAGGTGGTTTCCAGGGAATTTGAATGATTGTATTTTGTGTCCATGGAACGTTTATA

>57828_57828_1_NCOR1-CDRT4_NCOR1_chr17_15989596_ENST00000268712_CDRT4_chr17_15341517_ENST00000312177_length(amino acids)=1096AA_BP=1067
MVRTSLLIMSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFHPGSDRP
QERRTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRASADAKKDPAFGGKHEAPSSPISGQPCGDDQNAS
PSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRKKAEEAHKIFEGLGPKVE
LPLYNQPSDTKVYHENIKTNQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIRKQ
REQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLSVIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTD
HEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYYLTKKNENYKALVRRNYGKRRGRNQQIARPSQEEKVEEKEEDKAEKTEKKEEEK
KDEEEKDEKEDSKENTKEKDKIDGTAEETEEREQATPRGRKTANSQGRRKGRITRSMTNEAAAASAAAAAATEEPPPPLPPPPEPISTEP
VETSRWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCESVASTVSAQEDE
DIEASNEEENPEDSEVEAVKPSEDSPENATSRGNTEPAVELEPTTETAPSTSPSLAVPSTKPAEDESVETQVNDSISAETAEQMDVDQQE
HSAEEGSVCDPPPATKADSVDVEVRVPENHASKVEGDNTKERDLDRASEKVEPRDEDLVVAQQINAQRPEPQSDNDSSATCSADEDVDGE
PERQRMFPMDSKPSLLNPTGSILVSSPLKPNPLDLPQLQHRAAVIPPMVSCTPCNIPIGTPVSGYALYQRHIKAMHESALLEEQRQRQEQ
IDLECRSSTSPCGTSKSPNREWEVLQPAPHQVITNLPEGVRLPTTRPTRPPPPLIPSSKTTVASEKPSFIMGGSISQDSQKTLDFPGSYL

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Fusion Gene PPI Analysis for NCOR1-CDRT4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-2346254_3121059.02441.0SIN3A/B
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-2245254_3121075.02338.0SIN3A/B
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-23461_3731059.02441.0ZBTB33 and HEXIM1
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-22451_3731075.02338.0ZBTB33 and HEXIM1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-23461501_24401059.02441.0C1D
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-1191501_24400915.0C1D
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-22451501_24401075.02338.0C1D
HgeneNCOR1chr17:15989596chr17:15341517ENST00000268712-2346988_18161059.02441.0ETO
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-119988_18160915.0ETO
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395851-2245988_18161075.02338.0ETO
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-119254_3120915.0SIN3A/B
HgeneNCOR1chr17:15989596chr17:15341517ENST00000395848-1191_3730915.0ZBTB33 and HEXIM1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NCOR1-CDRT4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NCOR1-CDRT4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCOR1C0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneNCOR1C0005695Bladder Neoplasm1CTD_human
HgeneNCOR1C0006142Malignant neoplasm of breast1CGI;CTD_human
HgeneNCOR1C0007138Carcinoma, Transitional Cell1CTD_human
HgeneNCOR1C0014175Endometriosis1CTD_human
HgeneNCOR1C0017636Glioblastoma1CTD_human
HgeneNCOR1C0023903Liver neoplasms1CTD_human
HgeneNCOR1C0033578Prostatic Neoplasms1CTD_human
HgeneNCOR1C0269102Endometrioma1CTD_human
HgeneNCOR1C0334588Giant Cell Glioblastoma1CTD_human
HgeneNCOR1C0345904Malignant neoplasm of liver1CTD_human
HgeneNCOR1C0376358Malignant neoplasm of prostate1CTD_human
HgeneNCOR1C0678222Breast Carcinoma1CGI;CTD_human
HgeneNCOR1C0857007Hyperbilirubinemia, Neonatal1CTD_human
HgeneNCOR1C1257931Mammary Neoplasms, Human1CTD_human
HgeneNCOR1C1458155Mammary Neoplasms1CTD_human
HgeneNCOR1C1565885Direct Hyperbilirubinemia, Neonatal1CTD_human
HgeneNCOR1C1565886Indirect Hyperbilirubinemia, Neonatal1CTD_human
HgeneNCOR1C1621958Glioblastoma Multiforme1CTD_human
HgeneNCOR1C4704874Mammary Carcinoma, Human1CTD_human