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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NCOR2-RABGAP1 (FusionGDB2 ID:HG9612TG23637)

Fusion Gene Summary for NCOR2-RABGAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOR2-RABGAP1
Fusion gene ID: hg9612tg23637
HgeneTgene
Gene symbol

NCOR2

RABGAP1

Gene ID

9612

23637

Gene namenuclear receptor corepressor 2RAB GTPase activating protein 1
SynonymsCTG26|N-CoR2|SMAP270|SMRT|SMRTE|SMRTE-tau|TNRC14|TRAC|TRAC-1|TRAC1GAPCENA|TBC1D11
Cytomap('NCOR2')('RABGAP1')

12q24.31

9q33.2-q33.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor corepressor 2CTG repeat protein 26T3 receptor-associating factorsilencing mediator for retinoid and thyroid hormone receptorsthyroid-, retinoic-acid-receptor-associated corepressorrab GTPase-activating protein 1GAP and centrosome-associated proteinRab6 GTPase activating protein, GAPCenATBC1 domain family, member 11rab6 GTPase activating protein (GAP and centrosome-associated)rab6 GTPase-activating protein GAPCenA
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000356219, ENST00000397355, 
ENST00000404621, ENST00000405201, 
ENST00000429285, ENST00000404121, 
Fusion gene scores* DoF score35 X 38 X 19=2527012 X 10 X 4=480
# samples 5112
** MAII scorelog2(51/25270*10)=-5.63078460697328
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/480*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCOR2 [Title/Abstract] AND RABGAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNCOR2(124922476)-RABGAP1(125827627), # samples:1
Anticipated loss of major functional domain due to fusion event.NCOR2-RABGAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOR2-RABGAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOR2-RABGAP1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NCOR2-RABGAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NCOR2-RABGAP1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NCOR2-RABGAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRABGAP1

GO:0043087

regulation of GTPase activity

17562788


check buttonFusion gene breakpoints across NCOR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RABGAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A24L-01ANCOR2chr12

124922476

-RABGAP1chr9

125827627

+


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Fusion Gene ORF analysis for NCOR2-RABGAP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000356219ENST00000493854NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5CDS-3UTRENST00000397355ENST00000493854NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5CDS-3UTRENST00000404621ENST00000493854NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5CDS-3UTRENST00000405201ENST00000493854NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5CDS-3UTRENST00000429285ENST00000493854NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5CDS-5UTRENST00000356219ENST00000373643NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5CDS-5UTRENST00000397355ENST00000373643NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5CDS-5UTRENST00000404621ENST00000373643NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5CDS-5UTRENST00000405201ENST00000373643NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5CDS-5UTRENST00000429285ENST00000373643NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5UTR-3CDSENST00000404121ENST00000373647NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5UTR-3UTRENST00000404121ENST00000493854NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5UTR-5UTRENST00000404121ENST00000373643NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
Frame-shiftENST00000356219ENST00000373647NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
Frame-shiftENST00000397355ENST00000373647NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
Frame-shiftENST00000404621ENST00000373647NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
Frame-shiftENST00000429285ENST00000373647NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
In-frameENST00000405201ENST00000373647NCOR2chr12

124922476

-RABGAP1chr9

125827627

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000405201NCOR2chr12124922476-ENST00000373647RABGAP1chr9125827627+395288312298765

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000405201ENST00000373647NCOR2chr12124922476-RABGAP1chr9125827627+0.0005610970.99943894

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Fusion Genomic Features for NCOR2-RABGAP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NCOR2chr12124922475-RABGAP1chr9125827626+6.00E-060.99999404
NCOR2chr12124922475-RABGAP1chr9125827626+6.00E-060.99999404

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NCOR2-RABGAP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:124922476/chr9:125827627)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-948174_2152942522.0Coiled coilOntology_term=ECO:0000255
TgeneRABGAP1chr12:124922476chr9:125827627ENST000003736471226798_10475981070.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-948522_5612942522.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-9481384_13892942522.0Compositional biasNote=Poly-Pro
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-9481839_18432942522.0Compositional biasNote=Poly-Gly
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-9482476_24792942522.0Compositional biasNote=Poly-Pro
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-948494_5102942522.0Compositional biasNote=Poly-Gln
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-948682_6852942522.0Compositional biasNote=Poly-Lys
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-948778_8202942522.0Compositional biasNote=Pro-rich
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-948995_10032942522.0Compositional biasNote=Poly-Pro
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-948427_4782942522.0DomainSANT 1
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-948610_6612942522.0DomainSANT 2
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-9482136_21402942522.0MotifNote=CORNR box of ID1
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-9482339_23432942522.0MotifNote=CORNR box of ID2
TgeneRABGAP1chr12:124922476chr9:125827627ENST000003736471226142_2985981070.0DomainPID
TgeneRABGAP1chr12:124922476chr9:125827627ENST000003736471226566_7525981070.0DomainRab-GAP TBC


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Fusion Gene Sequence for NCOR2-RABGAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57882_57882_1_NCOR2-RABGAP1_NCOR2_chr12_124922476_ENST00000405201_RABGAP1_chr9_125827627_ENST00000373647_length(transcript)=3952nt_BP=883nt
CATGTCGGGATCCACACAGCCTGTGGCACAGACGTGGAGGGCCACTGAGCCCCGCTACCCGCCCCACAGCCTTTCCTACCCAGTGCAGAT
CGCCCGGACGCACACGGACGTCGGGCTCCTGGAGTACCAGCACCACTCCCGCGACTATGCCTCCCACCTGTCGCCCGGCTCCATCATCCA
GCCCCAGCGGCGGAGGCCCTCCCTGCTGTCTGAGTTCCAGCCCGGGAATGAACGGTCCCAGGAGCTCCACCTGCGGCCAGAGTCCCACTC
ATACCTGCCCGAGCTGGGGAAGTCAGAGATGGAGTTCATTGAAAGCAAGCGCCCTCGGCTAGAGCTGCTGCCTGACCCCCTGCTGCGACC
GTCACCCCTGCTGGCCACGGGCCAGCCTGCGGGATCTGAAGACCTCACCAAGGACCGTAGCCTGACGGGCAAGCTGGAACCGGTGTCTCC
CCCCAGCCCCCCGCACACTGACCCTGAGCTGGAGCTGGTGCCGCCACGGCTGTCCAAGGAGGAGCTGATCCAGAACATGGACCGCGTGGA
CCGAGAGATCACCATGGTAGAGCAGCAGATCTCTAAGCTGAAGAAGAAGCAGCAACAGCTGGAGGAGGAGGCTGCCAAGCCGCCCGAGCC
TGAGAAGCCCGTGTCACCGCCGCCCATCGAGTCGAAGCACCGCAGCCTGGTGCAGATCATCTACGACGAGAACCGGAAGAAGGCTGAAGC
TGCACATCGGATTCTGGAAGGCCTGGGGCCCCAGGTGGAGCTGCCGCTGTACAACCAGCCCTCCGACACCCGGCAGTATCATGAGAACAT
CAAAATAAACCAGGCGATGCGGAAGAAGCTAATCTTGTACTTCAAGAGGAGGAATCACGCTCGGAAACAATGGGAGTCTCCCCAGGACAG
TGCTATCACCCGGGATATTAACCGAACATTCCCAGCCCATGACTACTTTAAGGACACAGGAGGAGATGGACAAGATTCCTTATATAAAAT
ATGCAAGGCTTATTCTGTGTATGATGAAGAGATTGGTTATTGCCAGGGCCAGTCATTTCTTGCTGCTGTGCTCCTTCTCCATATGCCTGA
AGAACAGGCATTCAGTGTTCTGGTCAAGATCATGTTTGACTATGGGCTCAGGGAACTTTTCAAGCAAAACTTCGAAGATTTGCATTGCAA
ATTTTACCAGTTGGAGCGCCTCATGCAGGAATACATTCCTGACCTGTACAACCACTTCCTGGATATAAGCCTTGAAGCACACATGTATGC
CTCCCAGTGGTTTCTTACTCTTTTCACTGCAAAATTCCCTCTCTACATGGTCTTCCATATCATCGACCTGCTTTTATGTGAGGGAATAAG
TGTTATTTTTAATGTCGCCCTTGGATTATTAAAGACTTCGAAAGATGACCTGCTGTTGACAGACTTTGAAGGTGCCTTGAAGTTCTTTAG
GGTTCAGCTTCCTAAGAGATACCGCTCAGAAGAAAATGCAAAAAAACTAATGGAATTAGCCTGCAACATGAAGATTAGTCAGAAGAAGTT
GAAAAAATACGAGAAAGAATATCACACCATGAGGGAACAGCAGGCCCAGCAAGAAGACCCCATCGAGCGATTTGAGCGGGAGAATAGGCG
TCTACAAGAAGCTAACATGAGGTTGGAACAGGAAAACGATGACTTAGCCCATGAGCTGGTGACCAGCAAGATTGCACTACGGAAGGACCT
GGATAACGCTGAGGAAAAGGCAGATGCTCTGAATAAGGAGCTGCTGATGACCAAACAGAAGTTGATTGATGCAGAAGAAGAGAAAAGACG
GCTGGAAGAAGAGTCTGCTCAGTTAAAAGAAATGTGCCGTCGGGAACTCGACAAGGCAGAATCTGAGATTAAAAAAAACAGTTCTATCAT
TGGTGACTATAAGCAGATTTGTTCTCAGTTGAGTGAAAGATTGGAGAAGCAGCAGACAGCCAATAAGGTGGAAATTGAGAAAATTCGGCA
AAAAGTGGATGACTGTGAGCGGTGCCGGGAATTTTTCAACAAAGAAGGGCGTGTAAAAGGCATAAGCTCAACCAAGGAGGTTTTAGATGA
GGACACGGATGAAGAGAAAGAGACGCTCAAGAACCAGCTGAGAGAAATGGAGCTAGAACTGGCACAGACCAAACTCCAGCTGGTGGAGGC
CGAGTGTAAGATACAGGACTTGGAACACCATTTAGGGCTTGCCCTCAATGAGGTGCAGGCAGCCAAGAAGACGTGGTTTAACCGAACACT
GAGCTCCATAAAGACAGCAACCGGGGTTCAAGGGAAAGAGACTTGCTGAGAGCAGCTGCCGCCTCCCGACACCTTCAGAAAACACGACAC
CTTTTGTTGCCTTCTTTGGCCAGATGTGTGATTCTGTGACTTGTCCCAGGACCAGAATGTACCTAAGTCAGATCCATAGACGCATGTTGG
TAGGTCACTGGACCAGAGCTTGTGAAGCAGGCAACCTCTGGGGTAAGACTACTGATACTAACAGGCCTGCTAGCTCAGCCGACGCTCTGG
ACACTCTAGAAATCACTCCTCAGTGTGACCTCCCAGGCCTCTTCCCCGTGTACGTCAACACCTCACCCAGCCTAAAGGCTGAGTTTACAT
GATCAGAGTTAGGGGATCCTTCAGTCTGTTGATTTTTTTTCTAAACCTTTTTTTTTTAATATACATATATATATATATATATATATATAT
ATATATATATATATATATATATAGTGGGGGTGGGGCAAGGGATCAGAAATTCAAATAATTCTTTTCTGCTTCAATGCCAGCAGAAGGTCC
CCCAGGTAGACATGGAGAAGCACTTTGTTTTAAATAGGAGGGTTTCATAGTTGCATCTGAAGCCACCTGGTTCTGTTAAACTGTATGGTG
CAGGTTTTGGGTTTGGCATTATTCATGTTTCTGATCAATTCTATGCAACTCTCATAGTTCCTGTTACTTTTTAGCATTAGCTGCCAAATG
ACTTCAAAAGGCTGGGGTGGGTGACTTGACTGTGAGACTGGATTATAACATGGACAAATCTTATTTTGCTTAATGTGTTTGTGTGTGTGT
GTGTGTGTGTGTGTGTGTGTGTATGTATATATATATATAAATATCTTTCCCAATATGCCCCGTTGACAGTGTTTAAATTCCAGACTAGGA
CTGCTGATCTGCACAATTTAATTATGTGGTTATTCGAGCACTTAATTTCACTCAAGGTTCATTGGGCTCTGCTCTCCTCCCTGCCATTAC
GGGAGCTGTGGACAGAGCTCCCTCACTTCAAGATTCCTAGTGTTTTTGCACAACAGGTTGTCCAAGTGAGAAAGACTGAGTTGCGTGTCT
GTAAATGTCTGCGCAGGGTGCACATGCTGCGAGGTCTCCATCCTCCGGGCCTGTCCCTCCCAGATGGGCTGGGCCTTTGGGCCCTCCTCA
GAGTATGCCTGGGTACAAACCTCACTGTTCAGATGGGCTGTAAGTTCTCACTTCAAAGCTATGGAATGGATTTTAGCACCTTTAAAAAAA
AAAAAAACTTTGACTTTTAATTTATATAGTGATATGCTGACAGGCTGACACGCAGATGGTTTTGTCCTCTTTTCTGCGTTCAGTGTTGAG
GCGGCTGCTTACAAGAGGCACTGGTTTTGTATATAAAGACACTCGGGTTGTTTTGTAGCTCTTTTTCTTATTGGCTGTACTAACGCTTGC
TGAGGTTATCTGTAATAAGGGAGGTAACAAGTGGCAACCCCCTCCCCACCAACCATCCCCTTTGCTGCTTTCTGTGTCTTTCTTGTTCAG
TTACCAAAATAGCTGTAAGCCTATCTAATGCTAGGTGTGTGGACATTGTGCTAAGGTAGTTTCAGTGTGTCAACTTTATGAATTGAAATA
TAAACCAGTAAAATTGTATTACTGTTTCTTTTGTTGGTTTTATTTTAACAGCATATTGATTAAATATTTTGGTACAAACAAA

>57882_57882_1_NCOR2-RABGAP1_NCOR2_chr12_124922476_ENST00000405201_RABGAP1_chr9_125827627_ENST00000373647_length(amino acids)=765AA_BP=294
MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQPQRRRPSLLSEFQPGNERSQELHLRPESHS
YLPELGKSEMEFIESKRPRLELLPDPLLRPSPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD
REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENI
KINQAMRKKLILYFKRRNHARKQWESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPE
EQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGIS
VIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHTMREQQAQQEDPIERFERENRR
LQEANMRLEQENDDLAHELVTSKIALRKDLDNAEEKADALNKELLMTKQKLIDAEEEKRRLEEESAQLKEMCRRELDKAESEIKKNSSII
GDYKQICSQLSERLEKQQTANKVEIEKIRQKVDDCERCREFFNKEGRVKGISSTKEVLDEDTDEEKETLKNQLREMELELAQTKLQLVEA
ECKIQDLEHHLGLALNEVQAAKKTWFNRTLSSIKTATGVQGKETC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NCOR2-RABGAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-948254_312294.02522.0SIN3A/B


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NCOR2-RABGAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NCOR2-RABGAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCOR2C0023893Liver Cirrhosis, Experimental1CTD_human