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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KIAA0430-EEF2K (FusionGDB2 ID:HG9665TG29904)

Fusion Gene Summary for KIAA0430-EEF2K

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA0430-EEF2K
Fusion gene ID: hg9665tg29904
HgeneTgene
Gene symbol

KIAA0430

EEF2K

Gene ID

9665

29904

Gene namemeiosis regulator and mRNA stability factor 1eukaryotic elongation factor 2 kinase
SynonymsKIAA0430|LKAP|LMKB|PPP1R34CaMKIII|HSU93850|eEF-2K
Cytomap('KIAA0430')('EEF2K')

16p13.11

16p12.2

Type of geneprotein-codingprotein-coding
Descriptionmeiosis regulator and mRNA stability factor 1limkain-b1meiosis arrest female 1meiosis arrest female protein 1protein phosphatase 1, regulatory subunit 34eukaryotic elongation factor 2 kinasealternative protein EEF2Kcalcium/calmodulin-dependent eukaryotic elongation factor-2 kinasecalmodulin-dependent protein kinase IIIeEF-2 kinaseelongation factor-2 kinaseeukaroytic elongation factor 2 kinase
Modification date2020031320200313
UniProtAcc.

O00418

Ensembl transtripts involved in fusion geneENST00000344181, ENST00000396368, 
ENST00000540441, ENST00000548025, 
ENST00000551742, ENST00000602337, 
ENST00000547936, 
Fusion gene scores* DoF score5 X 7 X 4=1403 X 3 X 3=27
# samples 63
** MAII scorelog2(6/140*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KIAA0430 [Title/Abstract] AND EEF2K [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKIAA0430(15694285)-EEF2K(22291519), # samples:3
Anticipated loss of major functional domain due to fusion event.KIAA0430-EEF2K seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIAA0430-EEF2K seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIAA0430-EEF2K seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KIAA0430-EEF2K seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KIAA0430-EEF2K seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KIAA0430-EEF2K seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KIAA0430-EEF2K seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKIAA0430

GO:0010923

negative regulation of phosphatase activity

19389623

TgeneEEF2K

GO:0046777

protein autophosphorylation

9144159|23184662


check buttonFusion gene breakpoints across KIAA0430 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across EEF2K (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GC-A4ZW-01AKIAA0430chr16

15694285

-EEF2Kchr16

22291519

+


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Fusion Gene ORF analysis for KIAA0430-EEF2K

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000344181ENST00000561791KIAA0430chr16

15694285

-EEF2Kchr16

22291519

+
5CDS-intronENST00000396368ENST00000561791KIAA0430chr16

15694285

-EEF2Kchr16

22291519

+
5CDS-intronENST00000540441ENST00000561791KIAA0430chr16

15694285

-EEF2Kchr16

22291519

+
5CDS-intronENST00000548025ENST00000561791KIAA0430chr16

15694285

-EEF2Kchr16

22291519

+
5CDS-intronENST00000551742ENST00000561791KIAA0430chr16

15694285

-EEF2Kchr16

22291519

+
5CDS-intronENST00000602337ENST00000561791KIAA0430chr16

15694285

-EEF2Kchr16

22291519

+
Frame-shiftENST00000396368ENST00000263026KIAA0430chr16

15694285

-EEF2Kchr16

22291519

+
Frame-shiftENST00000540441ENST00000263026KIAA0430chr16

15694285

-EEF2Kchr16

22291519

+
Frame-shiftENST00000548025ENST00000263026KIAA0430chr16

15694285

-EEF2Kchr16

22291519

+
Frame-shiftENST00000551742ENST00000263026KIAA0430chr16

15694285

-EEF2Kchr16

22291519

+
Frame-shiftENST00000602337ENST00000263026KIAA0430chr16

15694285

-EEF2Kchr16

22291519

+
In-frameENST00000344181ENST00000263026KIAA0430chr16

15694285

-EEF2Kchr16

22291519

+
intron-3CDSENST00000547936ENST00000263026KIAA0430chr16

15694285

-EEF2Kchr16

22291519

+
intron-intronENST00000547936ENST00000561791KIAA0430chr16

15694285

-EEF2Kchr16

22291519

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000344181KIAA0430chr1615694285-ENST00000263026EEF2Kchr1622291519+7530460418146201479

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344181ENST00000263026KIAA0430chr1615694285-EEF2Kchr1622291519+0.0004873850.9995127

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Fusion Genomic Features for KIAA0430-EEF2K


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KIAA0430chr1615694284-EEF2Kchr1622291518+7.71E-070.9999993
KIAA0430chr1615694284-EEF2Kchr1622291518+7.71E-070.9999993

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KIAA0430-EEF2K


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:15694285/chr16:22291519)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EEF2K

O00418

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000396368-25271079_108216041743.0Compositional biasNote=Poly-Pro
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000396368-2527117_12516041743.0Compositional biasNote=Poly-Gly
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000548025-25271079_108216011740.0Compositional biasNote=Poly-Pro
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000548025-2527117_12516011740.0Compositional biasNote=Poly-Gly
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000551742-25271079_108216041743.0Compositional biasNote=Poly-Pro
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000551742-2527117_12516041743.0Compositional biasNote=Poly-Gly
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000602337-25271079_108216011740.0Compositional biasNote=Poly-Pro
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000602337-2527117_12516011740.0Compositional biasNote=Poly-Gly
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000396368-25271003_107916041743.0DomainHTH OST-type 2
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000396368-25271099_117316041743.0DomainHTH OST-type 3
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000396368-25271175_125016041743.0DomainHTH OST-type 4
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000396368-25271259_133416041743.0DomainHTH OST-type 5
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000396368-25271335_141016041743.0DomainHTH OST-type 6
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000396368-25271411_148516041743.0DomainHTH OST-type 7
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000396368-25271486_156016041743.0DomainHTH OST-type 8
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000396368-2527353_49016041743.0DomainNote=NYN
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000396368-2527791_87016041743.0DomainRRM
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000396368-2527875_94916041743.0DomainHTH OST-type 1
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000548025-25271003_107916011740.0DomainHTH OST-type 2
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000548025-25271099_117316011740.0DomainHTH OST-type 3
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000548025-25271175_125016011740.0DomainHTH OST-type 4
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000548025-25271259_133416011740.0DomainHTH OST-type 5
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000548025-25271335_141016011740.0DomainHTH OST-type 6
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000548025-25271411_148516011740.0DomainHTH OST-type 7
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000548025-25271486_156016011740.0DomainHTH OST-type 8
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000548025-2527353_49016011740.0DomainNote=NYN
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000548025-2527791_87016011740.0DomainRRM
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000548025-2527875_94916011740.0DomainHTH OST-type 1
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000551742-25271003_107916041743.0DomainHTH OST-type 2
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000551742-25271099_117316041743.0DomainHTH OST-type 3
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000551742-25271175_125016041743.0DomainHTH OST-type 4
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000551742-25271259_133416041743.0DomainHTH OST-type 5
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000551742-25271335_141016041743.0DomainHTH OST-type 6
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000551742-25271411_148516041743.0DomainHTH OST-type 7
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000551742-25271486_156016041743.0DomainHTH OST-type 8
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000551742-2527353_49016041743.0DomainNote=NYN
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000551742-2527791_87016041743.0DomainRRM
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000551742-2527875_94916041743.0DomainHTH OST-type 1
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000602337-25271003_107916011740.0DomainHTH OST-type 2
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000602337-25271099_117316011740.0DomainHTH OST-type 3
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000602337-25271175_125016011740.0DomainHTH OST-type 4
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000602337-25271259_133416011740.0DomainHTH OST-type 5
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000602337-25271335_141016011740.0DomainHTH OST-type 6
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000602337-25271411_148516011740.0DomainHTH OST-type 7
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000602337-25271486_156016011740.0DomainHTH OST-type 8
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000602337-2527353_49016011740.0DomainNote=NYN
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000602337-2527791_87016011740.0DomainRRM
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000602337-2527875_94916011740.0DomainHTH OST-type 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000396368-25271685_169016041743.0Compositional biasNote=Poly-Ser
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000548025-25271685_169016011740.0Compositional biasNote=Poly-Ser
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000551742-25271685_169016041743.0Compositional biasNote=Poly-Ser
HgeneKIAA0430chr16:15694285chr16:22291519ENST00000602337-25271685_169016011740.0Compositional biasNote=Poly-Ser
TgeneEEF2Kchr16:15694285chr16:22291519ENST000002630261518116_326629726.0DomainAlpha-type protein kinase
TgeneEEF2Kchr16:15694285chr16:22291519ENST000002630261518296_302629726.0Nucleotide bindingATP
TgeneEEF2Kchr16:15694285chr16:22291519ENST00000263026151881_94629726.0RegionCalmodulin-binding


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Fusion Gene Sequence for KIAA0430-EEF2K


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>42127_42127_1_KIAA0430-EEF2K_KIAA0430_chr16_15694285_ENST00000344181_EEF2K_chr16_22291519_ENST00000263026_length(transcript)=7530nt_BP=4604nt
GGAAGCGGAAGTGAAGGGTGCGCTTGGCGGCGGCGGCGGGAGCTGCGGAGTCGGGAATCAAAACAAAGGGCCTGGGGGGGGCGGGGGGAA
GGCGGCGGGGCCGGAATGTGAGCGGAGGTGGAGCCGGCGGCAGAGGGTGGAAGAATGAAAGAAAAGAAAGATGAAAGGATGTTGAATCAC
TTTGCATGGCTGTATGATGGAAGGAAACGGAACTGAGAACTCCTGCAGTAGAACACGTGGATGGCTTCAACAAGATAATGATGCTAAGCC
ATGGCTTTGGAAATTCTCTAATTGCTTTTCTCGTCCTGAGCAGACGCTGCCACATAGTCCCCAAACGAAAGAGTACATGGAGAACAAGAA
AGTTGCTGTGGAACTAAAGGATGTACCATCACCCCTTCATGCTGGCTCTAAGCTTTTTCCAGCAGTCCCACTTCCTGATATTCGTTCTCT
TCAGCAGCCTAAAATACAGCTTTCTTCTGTCCCCAAAGTAAGCTGCTGTGCTCATTGCCCTAATGAACCCTCCACTTCGCCAATGCGTTT
TGGTGGTGGTGGTGGCGGTAGCGGAGGTACCAGTAGCTTGATTCACCCGGGCGCACTGTTAGACTCGCAAAGCACCAGGACAATCACGTG
TCAGGTAGGGTCAGGGTTTGCTTTCCAGTCTGCATCTTCACTCCAGAATGCCTCAGCTAGGAACAATTTGGCAGGCATTGCAAGTGACTT
TCCCAGCATGTGTCTAGAGAGTAACCTGTCTTCCTGCAAACACCTGCCCTGTTGTGGAAAACTCCACTTCCAGTCATGTCATGGTAATGT
GCACAAGCTGCATCAGTTTCCGAGTCTGCAGGGCTGCACCTCCGCTGGCTATTTCCCCTGTTCTGATTTCACAAGCGGGGCTCCAGGGCA
TTTGGAAGAGCACATTTCACAGTCGGAGCTAACGCCTCACTTGTGCACCAACTCTTTGCACCTTAATGTGGTACCTCCGGTTTGTTTAAA
GGGCTCACTTTACTGCGAAGACTGTCTAAACAAGCCAGCAAGAAATAGCATAATCGATGCGGCTAAAGTCTGGCCAAATATACCACCTCC
AAATACTCAACCTGCACCTCTTGCTGTCCCTCTGTGTAATGGCTGTGGAACCAAAGGAACAGGGAAGGAGACCACGTTGTTATTGGCGAC
CAGTCTAGGCAAAGCTGCTTCAAAATTTGGGTCACCAGAAGTTGCAGTAGCTGGACAGGTGCTAGAAAACTTACCCCCCATTGGAGTTTT
TTGGGATATTGAAAACTGCTCCGTTCCCTCTGGCCGGTCAGCAACTGCTGTTGTGCAAAGAATCCGTGAGAAGTTTTTTAAAGGCCACAG
AGAAGCAGAATTCATCTGTGTATGTGACATCAGTAAAGAAAACAAGGAAGTTATTCAAGAGCTGAATAATTGCCAGGTAACCGTTGCCCA
CATCAATGCTACTGCAAAGAATGCCGCTGATGATAAACTGCGGCAGAGTCTCCGCAGATTTGCAAATACACACACTGCTCCAGCCACAGT
GGTTCTTGTGTCAACTGATGTCAATTTTGCATTGGAACTTAGTGACCTGAGACACAGGCATGGTTTCCACATTATTTTGGTCCATAAAAA
CCAGGCCTCAGAAGCACTGCTGCATCATGCTAACGAGCTGATCAGATTTGAAGAGTTCATTTCCGACTTGCCCCCCAGGTTACCACTAAA
AATGCCACAGTGCCACACTCTGCTCTATGTTTATAACCTACCAGCAAATAAGGATGGCAAGAGCGTCAGCAACAGGCTCAGACGCCTGTC
CGATAATTGTGGTGGGAAAGTGCTGAGTATCACAGGCTGCAGTGCAATTCTCCGCTTCATAAACCAAGATAGTGCAGAGCGCGCTCAGAA
GCGAATGGAAAACGAAGATGTCTTTGAGAAAAAAGATAAAGAGGAGACTGTATTCCAAGTGAGTTACCCGTCTGCTTTTAGCAAGTTAGT
TGCATCCAGGCAAGTCAGTCCTCTGCTCGCATCTCAGTCTTGGTCTTCTAGAGCATCCCCGCTTGCTTTCAACATTGCAAATTCGAGCAG
CGAAGCCGACTGCCCAGACCCATTTGCAAATGGTGCTGATGTCCAAGTCAGCAACATAGACTACAGATTATCCCGGAAGGAGCTGCAGCA
GCTCCTGCAGGAAGCATTTGCCAGGCATGGCAAGGTGAAGAGTGTTGAGCTCAGCCCCCATACAGATTATCAACTCAAGGCTGTTGTGCA
AATGGAAAACTTACAAGATGCGATCGGTGCAGTGAATAGCCTCCACAGATACAAAATTGGCAGCAAAAAGATCCTGGTCTCACTTGCCAC
CGGGGCTGCCAGCAAATCACTCTCTTTACTGAGGTTTGGACACAAGTTGAATGTGTCAGATCTATATAAATTAACAGACACGGTCGCAAT
CCGTGAACAAGGAAACGGACGGCTGGTGTGTCTCCTACCCAGCAGTCAGGCCCGCCAGAGCCCCTTGGGGTCTTCCCAGTCACACGACGG
CTCCTCCACGAATTGCAGCCCAATTATATTTGAAGAGTTAGAATATCACGAGCCTGTCTGCAGACAGCATTGTTCCAATAAGGATTTCAG
CTTTCCAGATTGTTACATTGCAGAGTTTGGCGATCTAGAAGTAGTGCAAGAAAACCAAGGAGGTGTTCCCTTAGAACACTTCATTACCTG
TGTTCCAGGTGTAAACATTGCCACTGCTCAGAATGGCATCAAAGTGGTTAAATGGATTCACAACAAGCCCCCGCCTCCCAACACTGACCC
TTGGCTTCTGCGTTCGAAGAGTCCTGTAGGTAACCCCCAGCTGATCCAGTTCAGTAGAGAAGTGATTGACTTGCTGAAAAGCCAGCCATC
TTGTGTCATACCCATCAGTCATTTCATCCCATCCTATCACCATCATTTTGCAAAGCAGTGCCGAGTGTCAGACTACGGATACTCCAAGCT
GATTGAGTTATTAGAAGCAGTGCCTCATGTATTGCAGATTCTTGGAATGGGCTCCAAACGTCTGCTGACCCTTACCCACAGGGCCCAGGT
GAAGCGCTTTACTCAGGATTTACTAAAACTTCTCAAATCCCAGGCCAGCAAACAGGTCATTGTGAGAGAATTCTCACAGGCTTATCACTG
GTGTTTCTCAAAGGACTGGGATGTCACTGAATATGGTGTTTGTGAGTTGATTGACATCGTATCAGAGATTCCAGACACAACCATCTGCTT
GTCCCAACAAGATAATGAAATGGTGATTTGTATCCCCAAAAGAGAACGCACTCAGGATGAAATAGAAAGGACAAAACAGTTCTCCAAGGA
TGTCGTTGATTTGCTGCGTCACCAACCCCATTTCCGGATGCCCTTTAATAAATTTATCCCTTCTTACCATCACCACTTTGGCCGGCAGTG
CAAACTTGCGTACTATGGGTTTACCAAACTACTTGAACTTTTTGAAGCCATACCTGATACTTTACAAGTATTGGAATGTGGAGAAGAAAA
GATCCTTACTCTGACAGAGGTGGAGCGGTTCAAAGCTCTAGCTGCCCAGTTTGTTAAACTCCTTCGGTCCCAAAAAGATAACTGCCTTAT
GATGACAGATCTCCTTACAGAATATGCTAAAACTTTTGGTTATACATTTCGTCTCCAAGACTATGATGTCAGTTCCATTTCGGCTTTAAC
TCAGAAACTCTGCCATGTCGTGAAGGTTGCCGATATAGAATCTGGCAGACAGATTCAGCTGATCAACCGAAAGTCTCTGCGATCTCTCAC
TGCCCAGTTGCTGGTATTGTTGATGTCTTGGGAAGGAACCACCCATCTTTCTGTTGAGGAGCTCAAGAGACATTACGAAAGTACCCACAA
CACTCCCCTTAACCCCTGTGAATATGGATTCATGACCTTGACCGAACTGCTGAAGAGCCTGCCATACTTGGTTGAGACCGCTGCAGCCTT
CGACTTGCAAATAGAACTGAAGTTTGCTGGAGGCTATAGCCTTCTCTTGGAGGAAATCCTTGAATATATCCCTCCTCCTTTTCTTTCTCC
TCTTCCTTCTTTCCTTCCTCCTCCTCCTTTCTTCTTCTTTGTCTTTTTTGTCATCTTCATCTTCTTCATCTTTGTCTTTGTCCAATTCGT
CGTCTTCGTCTTCTTTATCGTCGTCTTCGTCTTCTTCATCGTCGTCTTCGTTTTCACTAATGATAAGATGGAAGAATGTGTGAAGCTCAC
AAGTCTGTATTTGTTTGCAAAGAATGTGCGGTCTTTACTTCATACTTACCACTACCAGCAGATTTTCCTTCATGAGTTTTCCATGGCCTA
TACCAAGTATGTCGGAGAAACTCTGCAGCCCAAGACCTACGGCCACAGCAGCGTGGAGGAGCTCTTGGGAGCAATTCCACAGGTGGTTGT
TCAGTTTCTGCAAAAAAATGGCAAAGAGCTCTCATGTGAGAACTACCTTAATTTATATGCCAAAGCTGGTCGTTTGAGTTCACTCAGTCT
CTCCCCTGCCAATCATGAAAACCAGCCCTCGGAGGGCGAGCGCATCCTGGAGGTGCCCGAATCGCACACAGCCTCGGAACTCAAGCTTGG
AGCTGACGGCAGTGGTGCCAAGACTGGCTAGAGGCCCTGCACTGGTACAACACTGCCCTGGAGATGACGGACTGTGATGAGGGCGGTGAG
TACGACGGAATGCAGGACGAGCCCCGGTACATGATGCTGGCCAGGGAGGCCGAGATGCTGTTCACAGGAGGCTACGGGCTGGAGAAGGAC
CCGCAGAGATCAGGGGACTTGTATACCCAGGCAGCAGAGGCAGCGATGGAAGCCATGAAGGGCCGACTGGCCAACCAGTACTACCAAAAG
GCTGAAGAGGCCTGGGCCCAGATGGAGGAGTAACCAGGAAAATCACTGCCGGCTAGTCCCAAGCAAACGGGCTAGGAGGAAAGATTAAAA
AAACAACAACAACAACTTATTTAGTTTGGGGAGGGGAAGCATTTTTAAGTGTGTTGTAAAATCAAATTTTATATTTCATTTTTTGACTCT
TGAAAAATGTCTTTGCTCCTTGGCAGCTACCAGCAGAGACTCTATAGCTGTCTCTTAGGGCAGTATTTTGGGGAAGTGGGGCTTGAAGAA
GCAGCCTAATGAACCAACATACCGTTTTGTGTGTGGTTTTTTTTGTTTGTTTGTTTGTTTGTTTTGAGACAGAGTCTTGCTCTGTCACCC
AGGCTGGAGTGCAGTGACATGATCTTAGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCT
GGGATTACTGGTGCACACCACCACACTCAGCTAATTTTTGCATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAA
CTCCTAACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCATGCCTGCCCATTTTGTGGTTCT
ATTTTCATTTTTATTTCTTTTTTTTTTTTTGTCACGAGATATAAGAAAGTGCTTTTTGCCTTGAATGGACAATTTTAGGGCTGTGCTCAC
TAGTCTTTTCAGGCTGGACTGAAATGTCGGGCCCATGGAGCCCTGTGTTTTGTGCATCGGGATGAGAAATGAAGCACTTCACGCTGGCTT
TCCTAAGTCACGGGGCGTGTATTGCCGTGGCTTAGTGCAAAGCATTCTTTCTCAGAGCATTTAGAGGCATGCGTGGCATTTTTTCAGTGG
GTGTGAGATTGCACAATACCCAGGCTCCCTTCTACTGTGGGGAAGGGCCTGCATGTTGGCTGTTTTTTAAACTTCTAGTTCAATTTCCTT
CCATAATGCTACTGATTTTCTGGCATACAGCCGAATTCCATCTTTTAAGCATGCTTTCTACGGTGGGCTTTTCAAAACAGGTTTGAGTTT
TGTATGCACACGTTTACTACCTCTAACTCCTACATCAGCTAGTGTGGAAGAGGGTGCACCTCAAAGCTTTTACACGTAAGGACAGCGGCT
TGGAATGTGAGAGCCTTTTCTCCAAGCAGACCCACACTCTGCATCTCAGTGGCAGCTCCCACAACGTGACTGCAATGTCTCTTATACAGT
ATTCCTTGGTGTTTTCTTAGTGTCTGGATGTTCTTACGTGAAATCTGCTCCCCAGCCCTGGTCCTTGGCATTTTCTGCTTGAAGCTGGGC
TGATTTTCTTGTAATTTACAGCAGGACGCTTTCAGCAGCAGTCTCTTGGGATTTTATCTAAGATGTTTGAGGATGAGAGGGCAAGAACTA
TAAACACTCATTAATTCTAGTAGTCTCCCCATGGCCAGACAATGGCGATTGTTATTTAATGAGCTTTTCCTTTCAATGGAATTCAGCTCT
CACATTAGTATGATTTCATTTGATGTTTCAAATAGCAAAGATGCTAGGTGCGGTGGCTCCCGCCTGTAATCTCAGCACTTTGAGGAGGGC
CAAGGTGGGAGGATTGCTTGAGCTCAGGACTTCAAGACCAGCCTGGGTAAACATGGCGAGACCCTGTCTCTACCAAAACAACAAAAAAAA
GACAGACTGCTTTGATCAACCCTAAATGCAAAAGCAGCCTATTTTTCTTTGTTTAAAAGTCAAAACATAAAAAAGCAGAGTATAACATAC
AAACCATTCTTAACTATTCATTAAAATGGGTCCTTCAACACCTTAGTGGGGTTTGTTGTTGTTGCTTATGCAGAGAGATTATTTTCTTTT
TATTATTTTATAATTTTTGAAATAGAGATGGGGTCTCACTGTGTTGCCCAGGCTGGTCTCGAACTCCTGGACTTAAGTGAGCCTCCCGCC
TCAGTCTCCCAAAGCGCTGGGATTACAGGCAGGAGCCACTGAGCCCAGCCAAGACTTCAGTGTTGACTGCTTTGGAGGCACAAACCCATG
CAAGCGTTAGTTCCAAAGTTCAGTGTGTACCCTTAAATGAACAATGAAGCAGGTAAAATTACCCTTGAAAAAAATCCCTTGGACCACCCA
TAAATGACAGTGACTTTTTCAATATGGACTCATCATAGCCAGTTTTCCTTTTGAAGTTGGAACTGATCACCCTTTTGTCATCTGTACCAG
ATCAGTAGTTGGCTTGTGTTACATTTTGTGTGTGTGTGTGCGTGTTTTAAACCAGTGCATATAAATTGTATGTTAAATGTAAGTAACTTT
AAGTTGACTTATCTCTTCACAGTAATCAAGCCTCACGTAATTCATGCTTTTTAAATTCAGCCAGCCCCCCCTCTCTGAAATTTTATTATG
TAAATAATTTGTGTTCCCTGATCACTCGTTTAAGTTCTTAGTTGTATGTCATCTCTTCTCTAGCAGGAATTGGCAAACTTTTTTGTAAAG
GGGTAGAAAGTGAAGATTTTAGGCTTTGCAGGCCATATAGCCTCTGCTGCAAATGCTCAGCCCTGCTGTTGTAATGTAAAAGCTGCCACA

>42127_42127_1_KIAA0430-EEF2K_KIAA0430_chr16_15694285_ENST00000344181_EEF2K_chr16_22291519_ENST00000263026_length(amino acids)=1479AA_BP=
MHGCMMEGNGTENSCSRTRGWLQQDNDAKPWLWKFSNCFSRPEQTLPHSPQTKEYMENKKVAVELKDVPSPLHAGSKLFPAVPLPDIRSL
QQPKIQLSSVPKVSCCAHCPNEPSTSPMRFGGGGGGSGGTSSLIHPGALLDSQSTRTITCQVGSGFAFQSASSLQNASARNNLAGIASDF
PSMCLESNLSSCKHLPCCGKLHFQSCHGNVHKLHQFPSLQGCTSAGYFPCSDFTSGAPGHLEEHISQSELTPHLCTNSLHLNVVPPVCLK
GSLYCEDCLNKPARNSIIDAAKVWPNIPPPNTQPAPLAVPLCNGCGTKGTGKETTLLLATSLGKAASKFGSPEVAVAGQVLENLPPIGVF
WDIENCSVPSGRSATAVVQRIREKFFKGHREAEFICVCDISKENKEVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFANTHTAPATV
VLVSTDVNFALELSDLRHRHGFHIILVHKNQASEALLHHANELIRFEEFISDLPPRLPLKMPQCHTLLYVYNLPANKDGKSVSNRLRRLS
DNCGGKVLSITGCSAILRFINQDSAERAQKRMENEDVFEKKDKEETVFQVSYPSAFSKLVASRQVSPLLASQSWSSRASPLAFNIANSSS
EADCPDPFANGADVQVSNIDYRLSRKELQQLLQEAFARHGKVKSVELSPHTDYQLKAVVQMENLQDAIGAVNSLHRYKIGSKKILVSLAT
GAASKSLSLLRFGHKLNVSDLYKLTDTVAIREQGNGRLVCLLPSSQARQSPLGSSQSHDGSSTNCSPIIFEELEYHEPVCRQHCSNKDFS
FPDCYIAEFGDLEVVQENQGGVPLEHFITCVPGVNIATAQNGIKVVKWIHNKPPPPNTDPWLLRSKSPVGNPQLIQFSREVIDLLKSQPS
CVIPISHFIPSYHHHFAKQCRVSDYGYSKLIELLEAVPHVLQILGMGSKRLLTLTHRAQVKRFTQDLLKLLKSQASKQVIVREFSQAYHW
CFSKDWDVTEYGVCELIDIVSEIPDTTICLSQQDNEMVICIPKRERTQDEIERTKQFSKDVVDLLRHQPHFRMPFNKFIPSYHHHFGRQC
KLAYYGFTKLLELFEAIPDTLQVLECGEEKILTLTEVERFKALAAQFVKLLRSQKDNCLMMTDLLTEYAKTFGYTFRLQDYDVSSISALT
QKLCHVVKVADIESGRQIQLINRKSLRSLTAQLLVLLMSWEGTTHLSVEELKRHYESTHNTPLNPCEYGFMTLTELLKSLPYLVETAAAF
DLQIELKFAGGYSLLLEEILEYIPPPFLSPLPSFLPPPPFFFFVFFVIFIFFIFVFVQFVVFVFFIVVFVFFIVVFVFTNDKMEECVKLT
SLYLFAKNVRSLLHTYHYQQIFLHEFSMAYTKYVGETLQPKTYGHSSVEELLGAIPQVVVQFLQKNGKELSCENYLNLYAKAGRLSSLSL

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Fusion Gene PPI Analysis for KIAA0430-EEF2K


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KIAA0430-EEF2K


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KIAA0430-EEF2K


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource