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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CD68-STK17B (FusionGDB2 ID:HG968TG9262)

Fusion Gene Summary for CD68-STK17B

check button Fusion gene summary
Fusion gene informationFusion gene name: CD68-STK17B
Fusion gene ID: hg968tg9262
HgeneTgene
Gene symbol

CD68

STK17B

Gene ID

968

9262

Gene nameCD68 moleculeserine/threonine kinase 17b
SynonymsGP110|LAMP4|SCARD1DRAK2
Cytomap('CD68')('STK17B')

17p13.1

2q32.3

Type of geneprotein-codingprotein-coding
DescriptionmacrosialinCD68 antigenmacrophage antigen CD68scavenger receptor class D, member 1serine/threonine-protein kinase 17BDAP kinase-related apoptosis-inducing protein kinase 2death-associated protein kinase-related 2
Modification date2020031320200313
UniProtAcc

P34810

.
Ensembl transtripts involved in fusion geneENST00000250092, ENST00000380498, 
Fusion gene scores* DoF score5 X 5 X 2=502 X 2 X 1=4
# samples 52
** MAII scorelog2(5/50*10)=0log2(2/4*10)=2.32192809488736
Context

PubMed: CD68 [Title/Abstract] AND STK17B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCD68(7485224)-STK17B(197000641), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSTK17B

GO:0006468

protein phosphorylation

9786912

TgeneSTK17B

GO:0035556

intracellular signal transduction

9786912



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for CD68-STK17B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CD68-STK17B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for CD68-STK17B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:7485224/:197000641)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD68

P34810

.
FUNCTION: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CD68-STK17B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CD68-STK17B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CD68-STK17B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CD68-STK17B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCD68C0000786Spontaneous abortion1CTD_human
HgeneCD68C0000822Abortion, Tubal1CTD_human
HgeneCD68C0002152Alloxan Diabetes1CTD_human
HgeneCD68C0003872Arthritis, Psoriatic1CTD_human
HgeneCD68C0005398Cholestasis, Extrahepatic1CTD_human
HgeneCD68C0011853Diabetes Mellitus, Experimental1CTD_human
HgeneCD68C0020459Hyperinsulinism1CTD_human
HgeneCD68C0021655Insulin Resistance1CTD_human
HgeneCD68C0022116Ischemia1CTD_human
HgeneCD68C0022661Kidney Failure, Chronic1CTD_human
HgeneCD68C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCD68C0028754Obesity1CTD_human
HgeneCD68C0038433Streptozotocin Diabetes1CTD_human
HgeneCD68C0920563Insulin Sensitivity1CTD_human
HgeneCD68C1257963Endogenous Hyperinsulinism1CTD_human
HgeneCD68C1257964Exogenous Hyperinsulinism1CTD_human
HgeneCD68C1257965Compensatory Hyperinsulinemia1CTD_human
HgeneCD68C1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
HgeneCD68C1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
HgeneCD68C3830362Early Pregnancy Loss1CTD_human
HgeneCD68C4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human
HgeneCD68C4552766Miscarriage1CTD_human