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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ARHGEF11-SHC1 (FusionGDB2 ID:HG9826TG6464)

Fusion Gene Summary for ARHGEF11-SHC1

Fusion gene summary

Fusion gene information	Fusion gene name: ARHGEF11-SHC1
	Fusion gene ID: hg9826tg6464
		Hgene	Tgene
	Gene symbol	ARHGEF11	SHC1
	Gene ID	9826	6464
	Gene name	Rho guanine nucleotide exchange factor 11	SHC adaptor protein 1
	Synonyms	GTRAP48\|PDZ-RHOGEF	SHC\|SHCA
	Cytomap	('ARHGEF11')('SHC1') 1q23.1	1q21.3
	Type of gene	protein-coding	protein-coding
	Description	rho guanine nucleotide exchange factor 11Rho guanine exchange factor (GEF) 11Rho guanine nucleotide exchange factor (GEF) 11RhoA-specific guanine nucleotide exchange factorRhoGEF glutamate transport modulatorglutamate transporter EAAT4-associated pro	SHC-transforming protein 1SH2 domain protein C1SHC (Src homology 2 domain containing) transforming protein 1SHC-transforming protein 3SHC-transforming protein A
	Modification date	20200313	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000361409, ENST00000368194, ENST00000315174, ENST00000487682,
Fusion gene scores	* DoF score	11 X 5 X 7=385	11 X 4 X 8=352
	# samples	14	10
	** MAII score	log2(14/385*10)=-1.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/352*10)=-1.81557542886257 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ARHGEF11 [Title/Abstract] AND SHC1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ARHGEF11(157014091)-SHC1(154942675), # samples:3
Anticipated loss of major functional domain due to fusion event.	ARHGEF11-SHC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARHGEF11-SHC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARHGEF11-SHC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ARHGEF11-SHC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ARHGEF11	GO:0007186	G protein-coupled receptor signaling pathway	15755723
Hgene	ARHGEF11	GO:0007266	Rho protein signal transduction	10026210
Hgene	ARHGEF11	GO:0045893	positive regulation of transcription, DNA-templated	10026210
Tgene	SHC1	GO:0000165	MAPK cascade	14676841
Tgene	SHC1	GO:0000187	activation of MAPK activity	14676841
Tgene	SHC1	GO:0071363	cellular response to growth factor stimulus	20010870

Fusion gene breakpoints across ARHGEF11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SHC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-AB2O-01A	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
ChimerDB4	SARC	TCGA-DX-AB2V-01A	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-

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Fusion Gene ORF analysis for ARHGEF11-SHC1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000361409	ENST00000368450	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
5CDS-5UTR	ENST00000361409	ENST00000368453	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
5CDS-5UTR	ENST00000368194	ENST00000368450	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
5CDS-5UTR	ENST00000368194	ENST00000368453	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
5CDS-intron	ENST00000361409	ENST00000368449	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
5CDS-intron	ENST00000361409	ENST00000448116	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
5CDS-intron	ENST00000361409	ENST00000490667	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
5CDS-intron	ENST00000361409	ENST00000606391	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
5CDS-intron	ENST00000368194	ENST00000368449	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
5CDS-intron	ENST00000368194	ENST00000448116	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
5CDS-intron	ENST00000368194	ENST00000490667	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
5CDS-intron	ENST00000368194	ENST00000606391	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
In-frame	ENST00000361409	ENST00000368445	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
In-frame	ENST00000368194	ENST00000368445	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
intron-3CDS	ENST00000315174	ENST00000368445	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
intron-3CDS	ENST00000487682	ENST00000368445	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
intron-5UTR	ENST00000315174	ENST00000368450	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
intron-5UTR	ENST00000315174	ENST00000368453	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
intron-5UTR	ENST00000487682	ENST00000368450	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
intron-5UTR	ENST00000487682	ENST00000368453	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
intron-intron	ENST00000315174	ENST00000368449	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
intron-intron	ENST00000315174	ENST00000448116	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
intron-intron	ENST00000315174	ENST00000490667	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
intron-intron	ENST00000315174	ENST00000606391	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
intron-intron	ENST00000487682	ENST00000368449	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
intron-intron	ENST00000487682	ENST00000448116	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
intron-intron	ENST00000487682	ENST00000490667	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-
intron-intron	ENST00000487682	ENST00000606391	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000368194	ARHGEF11	chr1	157014091	-	ENST00000368445	SHC1	chr1	154942675	-	4002	1072	3064	3624	186
ENST00000361409	ARHGEF11	chr1	157014091	-	ENST00000368445	SHC1	chr1	154942675	-	3705	775	2767	3327	186

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000368194	ENST00000368445	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-	0.67627233	0.32372767
ENST00000361409	ENST00000368445	ARHGEF11	chr1	157014091	-	SHC1	chr1	154942675	-	0.68281937	0.31718066

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Fusion Genomic Features for ARHGEF11-SHC1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for ARHGEF11-SHC1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:157014091/chr1:154942675)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SHC1

chr1:157014091

chr1:154942675

ENST00000368445

411_474

584.0

Compositional bias

Note=Pro-rich

Tgene

SHC1

chr1:157014091

chr1:154942675

ENST00000368450

411_474

474.0

Compositional bias

Note=Pro-rich

Tgene

SHC1

chr1:157014091

chr1:154942675

ENST00000368453

411_474

475.0

Compositional bias

Note=Pro-rich

Tgene

SHC1

chr1:157014091

chr1:154942675

ENST00000448116

411_474

585.0

Compositional bias

Note=Pro-rich

Tgene

SHC1

chr1:157014091

chr1:154942675

ENST00000368445

156_339

584.0

Domain

PID

Tgene

SHC1

chr1:157014091

chr1:154942675

ENST00000368445

488_579

584.0

Domain

SH2

Tgene

SHC1

chr1:157014091

chr1:154942675

ENST00000368450

156_339

474.0

Domain

PID

Tgene

SHC1

chr1:157014091

chr1:154942675

ENST00000368450

488_579

474.0

Domain

SH2

Tgene

SHC1

chr1:157014091

chr1:154942675

ENST00000368453

156_339

475.0

Domain

PID

Tgene

SHC1

chr1:157014091

chr1:154942675

ENST00000368453

488_579

475.0

Domain

SH2

Tgene

SHC1

chr1:157014091

chr1:154942675

ENST00000448116

156_339

585.0

Domain

PID

Tgene

SHC1

chr1:157014091

chr1:154942675

ENST00000448116

488_579

585.0

Domain

SH2

Tgene

SHC1

chr1:157014091

chr1:154942675

ENST00000368445

340_487

584.0

Region

Note=CH1

Tgene

SHC1

chr1:157014091

chr1:154942675

ENST00000368450

340_487

474.0

Region

Note=CH1

Tgene

SHC1

chr1:157014091

chr1:154942675

ENST00000368453

340_487

475.0

Region

Note=CH1

Tgene

SHC1

chr1:157014091

chr1:154942675

ENST00000448116

340_487

585.0

Region

Note=CH1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARHGEF11

chr1:157014091

chr1:154942675

ENST00000361409

444_470

1523.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ARHGEF11

chr1:157014091

chr1:154942675

ENST00000368194

444_470

1563.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ARHGEF11

chr1:157014091

chr1:154942675

ENST00000361409

1094_1099

1523.0

Compositional bias

Note=Poly-Pro

Hgene

ARHGEF11

chr1:157014091

chr1:154942675

ENST00000368194

1094_1099

1563.0

Compositional bias

Note=Poly-Pro

Hgene

ARHGEF11

chr1:157014091

chr1:154942675

ENST00000361409

306_486

1523.0

Domain

RGSL

Hgene

ARHGEF11

chr1:157014091

chr1:154942675

ENST00000361409

47_126

1523.0

Domain

PDZ

Hgene

ARHGEF11

chr1:157014091

chr1:154942675

ENST00000361409

734_923

1523.0

Domain

Hgene

ARHGEF11

chr1:157014091

chr1:154942675

ENST00000361409

965_1079

1523.0

Domain

Hgene

ARHGEF11

chr1:157014091

chr1:154942675

ENST00000368194

306_486

1563.0

Domain

RGSL

Hgene

ARHGEF11

chr1:157014091

chr1:154942675

ENST00000368194

47_126

1563.0

Domain

PDZ

Hgene

ARHGEF11

chr1:157014091

chr1:154942675

ENST00000368194

734_923

1563.0

Domain

Hgene

ARHGEF11

chr1:157014091

chr1:154942675

ENST00000368194

965_1079

1563.0

Domain

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Fusion Gene Sequence for ARHGEF11-SHC1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>6200_6200_1_ARHGEF11-SHC1_ARHGEF11_chr1_157014091_ENST00000361409_SHC1_chr1_154942675_ENST00000368445_length(transcript)=3705nt_BP=775nt
AATTGGCTCATTTAAGAATTTCAAAACATTTAATGTAAAAGCTTTTTTTTTTTTAAGGAAGTCCATAAATTTTGGTTCCCAGGGTTGCAC
TGGACTTGGAAGGAGTGCTGTTGTGTACATACTATTGTATGGTTTTATTTATTATTTTACTGTACAAATCAGCCGAAAGAATTTTTCCAA
GTGCCATTTCGGATTTATTAATCCTTTTTTTTTTCCTTTCCTCAAAGATATTTGCTGTTGTCATATTAAGCATTGGAGACTAGAAAATTA
CTTTCCCCCTTTGAGCTAGAGGGTCTCTTGCCAACAGAAGGACAGCTGAGAAAGCTGGATTTAAAGGATGGTTTTATCTGTACTTTGCAG
TTAACAGTGATATTTTGAAGGCACATTTTTCTGTGATTCATTTTTTTTTGGCCATAGTGCTAACCTTGAAGAGATTCGTGGCTGGGTTTT
TGGTTTCTGAGAAGGTCGTAGTTTTTCCTCTTTTCCTTTTTTTTTCTTTTTTCTTTTCTTTTCTTTTTTTTTAAAGCGGGGGAGGGGAAG
AGGGGCTGAGAAAGGAAATCATGTTCACTGGTAGAAGTAGAGTGGAGCATCAGTTACCAGGGTCCTGAGAGCTGGAGGAGAAAGGATTCT
ATCTTCAAGTTGGGAGGCCCTCCTCTCACCTTGCTCAAAAATTGCAAGCGATTCAATCCTGATCAAGACACCAAAGCTACAGGATTCTGG
AACCGTGGAGACACCGAGAAACCATGAGTGTAAGGTTACCCCAGAGTATAGACAGGTTCGGACTAAGGATCACCGCTTTGAAAGTGTCAG
TCACCTTATCAGCTACCACATGGACAATCACTTGCCCATCATCTCTGCGGGCAGCGAACTGTGTCTACAGCAACCTGTGGAGCGGAAACT
GTGATCTGCCCTAGCGCTCTCTTCCAGAAGATGCCCTCCAATCCTTTCCACCCTATTCCCTAACTCTCGGGACCTCGTTTGGGAGTGTTC
TGTGGGCTTGGCCTTGTGTCAGAGCTGGGAGTAGCATGGACTCTGGGTTTCATATCCAGCTGAGTGAGAGGGTTTGAGTCAAAAGCCTGG
GTGAGAATCCTGCCTCTCCCCAAACATTAATCACCAAAGTATTAATGTACAGAGTGGCCCCTCACCTGGGCCTTTCCTGTGCCAACCTGA
TGCCCCTTCCCCAAGAAGGTGAGTGCTTGTCATGGAAAATGTCCTGTGGTGACAGGCCCAGTGGAACAGTCACCCTTCTGGGCAAGGGGG
AACAAATCACACCTCTGGGCTTCAGGGTATCCCAGACCCCTCTCAACACCCGCCCCCCCCATGTTTAAACTTTGTGCCTTTGACCATCTC
TTAGGTCTAATGATATTTTATGCAAACAGTTCTTGGACCCCTGAATTCAATGACAGGGATGCCAACACCTTCTTGGCTTCTGGGACCTGT
GTTCTTGCTGAGCACCCTCTCCGGTTTGGGTTGGGATAACAGAGGCAGGAGTGGCAGCTGTCCCCTCTCCCTGGGGATATGCAACCCTTA
GAGATTGCCCCAGAGCCCCACTCCCGGCCAGGCGGGAGATGGACCCCTCCCTTGCTCAGTGCCTCCTGGCCGGGGCCCCTCACCCCAAGG
GGTCTGTATATACATTTCATAAGGCCTGCCCTCCCATGTTGCATGCCTATGTACTCTACGCCAAAGTGCAGCCCTTCCTCCTGAAGCCTC
TGCCCTGCCTCCCTTTCTGGGAGGGCGGGGTGGGGGTGACTGAATTTGGGCCTCTTGTACAGTTAACTCTCCCAGGTGGATTTTGTGGAG
GTGAGAAAAGGGGCATTGAGACTATAAAGCAGTAGACAATCCCCACATACCATCTGTAGAGTTGGAACTGCATTCTTTTAAAGTTTTATA
TGCATATATTTTAGGGCTGTAGACTTACTTTCCTATTTTCTTTTCCATTGCTTATTCTTGAGCACAAAATGATAATCAATTATTACATTT
ATACATCACCTTTTTGACTTTTCCAAGCCCTTTTACAGCTCTTGGCATTTTCCTCGCCTAGGCCTGTGAGGTAACTGGGATCGCACCTTT
TATACCAGAGACCTGAGGCAGATGAAATTTATTTCCATCTAGGACTAGAAAAACTTGGGTCTCTTACCGCGAGACTGAGAGGCAGAAGTC
AGCCCGAATGCCTGTCAGTTTCATGGAGGGGAAACGCAAAACCTGCAGTTCCTGAGTACCTTCTACAGGCCCGGCCCAGCCTAGGCCCGG
GGTGGCCACACCACAGCAAGCCGGCCCCCCCTCTTTTGGCCTTGTGGATAAGGGAGAGTTGACCGTTTTCATCCTGGCCTCCTTTTGCTG
TTTGGATGTTTCCACGGGTCTCACTTATACCAAAGGGAAAACTCTTCATTAAAGTCCGTATTTCTTCTAAGCCCTTCGAAGATGCTCTTC
GCGTGCCTCCACCTCCCCAGTCGGTGTCCATGGCTGAGCAGCTCCGAGGGGAGCCCTGGTTCCATGGGAAGCTGAGCCGGCGGGAGGCTG
AGGCACTGCTGCAGCTCAATGGGGACTTCCTGGTACGGGAGAGCACGACCACACCTGGCCAGTATGTGCTCACTGGCTTGCAGAGTGGGC
AGCCTAAGCATTTGCTACTGGTGGACCCTGAGGGTGTGGCAGAGAGCTTTTTGATGATCCCTCCTATGTCAACGTCCAGAACCTAGACAA
GGCCCGGCAAGCAGTGGGTGGTGCTGGGCCCCCCAATCCTGCTATCAATGGCAGTGCACCCCGGGACCTGTTTGACATGACCTGTAGGAC
AGCCTGTTGGGGGAGATCCAGAAGTCCGCAAACAGATGCCACCTCCACCACCCTGTCCAGGATGGCTGGCTTTGATGGCTCAGCATGGGA
TGAGGAGGAGGAAGAGCCACCTGACCATCAGTACTATAATGACTTCCCGGGGAAGGAACCCCCCTTGGGGGGGGTGGTAGACATGAGGCT
TCGGGAAGGAGCCGCTCCAGGGGCTGCTCGACCCACTGCACCCAATGCCCAGACCCCCAGCCACTTGGGAGCTACATTGCCTGCCACATT
CTGGAGTGTCCCGAAGGGCTTGCCCAGGATGTCATCAGCACCATTGGCCAGGCCTTCGAGTTGCGCTTCAAACAATACCTCAGGAACCCA
CCCAAACTGGTCACCCCTCATGACAGGACACAGCCGAGTATGTCGCCTATGTTGCCAAAGACCCTGTGAATCAGAGAGATCATCGCCAAC
CACCACATGCAATCTATCTCATTTGCATCCGGCGGGGATCCGCCCTGTAGCCGCCCGCTCAGCTCTATCCTGGGGAGGAGTAACCTGAAA
TTTGCTGGAATGCCAATCACTCTCACCGTCTCCACCAGCAGCCTCAACCTCATGGCCGCAGACTGCAAACAGGGAGGCCATCAGTCTGGT
GTGTGAGGCTGTGCCGGGTGCTAAGGGGGCGACAAGGAGGAGAAAGTACATGGGTTGTGTGGAGGTCCTCCAGTCAATGCGTGCCCTGGA
CTTCAACACCCGGACTCAGGTCACCAGGACATGAACAAGCTGAGTGGAGGCGGCGGGCGCAGGACTCGGGTGGAAGGGGGCCAGCTTGGG
GGCGAGGAGTGGACCCGCCACGGGAGCTTTGTCAATAAGCCCACGCGGGGCTGGCTGCATCCCAACGACAAAGTCATGGGACCCGGGGTT

>6200_6200_1_ARHGEF11-SHC1_ARHGEF11_chr1_157014091_ENST00000361409_SHC1_chr1_154942675_ENST00000368445_length(amino acids)=186AA_BP=131
MFDMTCRTACWGRSRSPQTDATSTTLSRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHL
GATLPATFWSVPKGLPRMSSAPLARPSSCASNNTSGTHPNWSPLMTGHSRVCRLCCQRPCESERSSPTTTCNLSHLHPAGIRPVAARSAL

--------------------------------------------------------------
>6200_6200_2_ARHGEF11-SHC1_ARHGEF11_chr1_157014091_ENST00000368194_SHC1_chr1_154942675_ENST00000368445_length(transcript)=4002nt_BP=1072nt
AGCGAAATCTCCGTTTCATGGAGGCTGAGGCAAGAGAAAATTTCGGAGCCTGGATGTGGAGGAGCCCAACAGCAGAACTAACTCAGGAAA
TTGTCTTTCAGAAAAAGGCCGAACGTAGGCTGGGTCTGAGAATCAGGCTGGGGTAGGTGGAGGAACCTGCAAGTTTAAAGGAAAAAGAAA
AGGAGAGAATATTTTCAGAGATTATCTCTGGTTTGTTATCATTACTACCATCTTAAAGGTAAAAAGCATTGCATTTCAGGTGTTCTTTGA
TTTTTATTTTATTTTTTTTTTTGGTGCAATTGGCTCATTTAAGAATTTCAAAACATTTAATGTAAAAGCTTTTTTTTTTTTAAGGAAGTC
CATAAATTTTGGTTCCCAGGGTTGCACTGGACTTGGAAGGAGTGCTGTTGTGTACATACTATTGTATGGTTTTATTTATTATTTTACTGT
ACAAATCAGCCGAAAGAATTTTTCCAAGTGCCATTTCGGATTTATTAATCCTTTTTTTTTTCCTTTCCTCAAAGATATTTGCTGTTGTCA
TATTAAGCATTGGAGACTAGAAAATTACTTTCCCCCTTTGAGCTAGAGGGTCTCTTGCCAACAGAAGGACAGCTGAGAAAGCTGGATTTA
AAGGATGGTTTTATCTGTACTTTGCAGTTAACAGTGATATTTTGAAGGCACATTTTTCTGTGATTCATTTTTTTTTGGCCATAGTGCTAA
CCTTGAAGAGATTCGTGGCTGGGTTTTTGGTTTCTGAGAAGGTCGTAGTTTTTCCTCTTTTCCTTTTTTTTTCTTTTTTCTTTTCTTTTC
TTTTTTTTTAAAGCGGGGGAGGGGAAGAGGGGCTGAGAAAGGAAATCATGTTCACTGGTAGAAGTAGAGTGGAGCATCAGTTACCAGGGT
CCTGAGAGCTGGAGGAGAAAGGATTCTATCTTCAAGTTGGGAGGCCCTCCTCTCACCTTGCTCAAAAATTGCAAGCGATTCAATCCTGAT
CAAGACACCAAAGCTACAGGATTCTGGAACCGTGGAGACACCGAGAAACCATGAGTGTAAGGTTACCCCAGAGTATAGACAGGTTCGGAC
TAAGGATCACCGCTTTGAAAGTGTCAGTCACCTTATCAGCTACCACATGGACAATCACTTGCCCATCATCTCTGCGGGCAGCGAACTGTG
TCTACAGCAACCTGTGGAGCGGAAACTGTGATCTGCCCTAGCGCTCTCTTCCAGAAGATGCCCTCCAATCCTTTCCACCCTATTCCCTAA
CTCTCGGGACCTCGTTTGGGAGTGTTCTGTGGGCTTGGCCTTGTGTCAGAGCTGGGAGTAGCATGGACTCTGGGTTTCATATCCAGCTGA
GTGAGAGGGTTTGAGTCAAAAGCCTGGGTGAGAATCCTGCCTCTCCCCAAACATTAATCACCAAAGTATTAATGTACAGAGTGGCCCCTC
ACCTGGGCCTTTCCTGTGCCAACCTGATGCCCCTTCCCCAAGAAGGTGAGTGCTTGTCATGGAAAATGTCCTGTGGTGACAGGCCCAGTG
GAACAGTCACCCTTCTGGGCAAGGGGGAACAAATCACACCTCTGGGCTTCAGGGTATCCCAGACCCCTCTCAACACCCGCCCCCCCCATG
TTTAAACTTTGTGCCTTTGACCATCTCTTAGGTCTAATGATATTTTATGCAAACAGTTCTTGGACCCCTGAATTCAATGACAGGGATGCC
AACACCTTCTTGGCTTCTGGGACCTGTGTTCTTGCTGAGCACCCTCTCCGGTTTGGGTTGGGATAACAGAGGCAGGAGTGGCAGCTGTCC
CCTCTCCCTGGGGATATGCAACCCTTAGAGATTGCCCCAGAGCCCCACTCCCGGCCAGGCGGGAGATGGACCCCTCCCTTGCTCAGTGCC
TCCTGGCCGGGGCCCCTCACCCCAAGGGGTCTGTATATACATTTCATAAGGCCTGCCCTCCCATGTTGCATGCCTATGTACTCTACGCCA
AAGTGCAGCCCTTCCTCCTGAAGCCTCTGCCCTGCCTCCCTTTCTGGGAGGGCGGGGTGGGGGTGACTGAATTTGGGCCTCTTGTACAGT
TAACTCTCCCAGGTGGATTTTGTGGAGGTGAGAAAAGGGGCATTGAGACTATAAAGCAGTAGACAATCCCCACATACCATCTGTAGAGTT
GGAACTGCATTCTTTTAAAGTTTTATATGCATATATTTTAGGGCTGTAGACTTACTTTCCTATTTTCTTTTCCATTGCTTATTCTTGAGC
ACAAAATGATAATCAATTATTACATTTATACATCACCTTTTTGACTTTTCCAAGCCCTTTTACAGCTCTTGGCATTTTCCTCGCCTAGGC
CTGTGAGGTAACTGGGATCGCACCTTTTATACCAGAGACCTGAGGCAGATGAAATTTATTTCCATCTAGGACTAGAAAAACTTGGGTCTC
TTACCGCGAGACTGAGAGGCAGAAGTCAGCCCGAATGCCTGTCAGTTTCATGGAGGGGAAACGCAAAACCTGCAGTTCCTGAGTACCTTC
TACAGGCCCGGCCCAGCCTAGGCCCGGGGTGGCCACACCACAGCAAGCCGGCCCCCCCTCTTTTGGCCTTGTGGATAAGGGAGAGTTGAC
CGTTTTCATCCTGGCCTCCTTTTGCTGTTTGGATGTTTCCACGGGTCTCACTTATACCAAAGGGAAAACTCTTCATTAAAGTCCGTATTT
CTTCTAAGCCCTTCGAAGATGCTCTTCGCGTGCCTCCACCTCCCCAGTCGGTGTCCATGGCTGAGCAGCTCCGAGGGGAGCCCTGGTTCC
ATGGGAAGCTGAGCCGGCGGGAGGCTGAGGCACTGCTGCAGCTCAATGGGGACTTCCTGGTACGGGAGAGCACGACCACACCTGGCCAGT
ATGTGCTCACTGGCTTGCAGAGTGGGCAGCCTAAGCATTTGCTACTGGTGGACCCTGAGGGTGTGGCAGAGAGCTTTTTGATGATCCCTC
CTATGTCAACGTCCAGAACCTAGACAAGGCCCGGCAAGCAGTGGGTGGTGCTGGGCCCCCCAATCCTGCTATCAATGGCAGTGCACCCCG
GGACCTGTTTGACATGACCTGTAGGACAGCCTGTTGGGGGAGATCCAGAAGTCCGCAAACAGATGCCACCTCCACCACCCTGTCCAGGAT
GGCTGGCTTTGATGGCTCAGCATGGGATGAGGAGGAGGAAGAGCCACCTGACCATCAGTACTATAATGACTTCCCGGGGAAGGAACCCCC
CTTGGGGGGGGTGGTAGACATGAGGCTTCGGGAAGGAGCCGCTCCAGGGGCTGCTCGACCCACTGCACCCAATGCCCAGACCCCCAGCCA
CTTGGGAGCTACATTGCCTGCCACATTCTGGAGTGTCCCGAAGGGCTTGCCCAGGATGTCATCAGCACCATTGGCCAGGCCTTCGAGTTG
CGCTTCAAACAATACCTCAGGAACCCACCCAAACTGGTCACCCCTCATGACAGGACACAGCCGAGTATGTCGCCTATGTTGCCAAAGACC
CTGTGAATCAGAGAGATCATCGCCAACCACCACATGCAATCTATCTCATTTGCATCCGGCGGGGATCCGCCCTGTAGCCGCCCGCTCAGC
TCTATCCTGGGGAGGAGTAACCTGAAATTTGCTGGAATGCCAATCACTCTCACCGTCTCCACCAGCAGCCTCAACCTCATGGCCGCAGAC
TGCAAACAGGGAGGCCATCAGTCTGGTGTGTGAGGCTGTGCCGGGTGCTAAGGGGGCGACAAGGAGGAGAAAGTACATGGGTTGTGTGGA
GGTCCTCCAGTCAATGCGTGCCCTGGACTTCAACACCCGGACTCAGGTCACCAGGACATGAACAAGCTGAGTGGAGGCGGCGGGCGCAGG
ACTCGGGTGGAAGGGGGCCAGCTTGGGGGCGAGGAGTGGACCCGCCACGGGAGCTTTGTCAATAAGCCCACGCGGGGCTGGCTGCATCCC

>6200_6200_2_ARHGEF11-SHC1_ARHGEF11_chr1_157014091_ENST00000368194_SHC1_chr1_154942675_ENST00000368445_length(amino acids)=186AA_BP=131
MFDMTCRTACWGRSRSPQTDATSTTLSRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHL
GATLPATFWSVPKGLPRMSSAPLARPSSCASNNTSGTHPNWSPLMTGHSRVCRLCCQRPCESERSSPTTTCNLSHLHPAGIRPVAARSAL

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Fusion Gene PPI Analysis for ARHGEF11-SHC1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ARHGEF11-SHC1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ARHGEF11-SHC1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ARHGEF11	C0036341	Schizophrenia	2	PSYGENET
Tgene		C0018800	Cardiomegaly	1	CTD_human
Tgene		C0019193	Hepatitis, Toxic	1	CTD_human
Tgene		C0860207	Drug-Induced Liver Disease	1	CTD_human
Tgene		C1262760	Hepatitis, Drug-Induced	1	CTD_human
Tgene		C1383860	Cardiac Hypertrophy	1	CTD_human
Tgene		C1862939	AMYOTROPHIC LATERAL SCLEROSIS 1	1	CTD_human
Tgene		C1862941	Amyotrophic Lateral Sclerosis, Sporadic	1	CTD_human
Tgene		C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
Tgene		C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
Tgene		C4279912	Chemically-Induced Liver Toxicity	1	CTD_human
Tgene		C4551993	Amyotrophic Lateral Sclerosis, Familial	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:ARHGEF11-SHC1 (FusionGDB2 ID:HG9826TG6464)

Fusion Gene Summary for ARHGEF11-SHC1

Fusion Gene ORF analysis for ARHGEF11-SHC1

Fusion Genomic Features for ARHGEF11-SHC1

Fusion Protein Features for ARHGEF11-SHC1

Fusion Gene Sequence for ARHGEF11-SHC1

Fusion Gene PPI Analysis for ARHGEF11-SHC1

Related Drugs for ARHGEF11-SHC1

Related Diseases for ARHGEF11-SHC1

Fusion Gene Studies
in Kim Lab