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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:ARHGEF17-CLPB (FusionGDB2 ID:HG9828TG81570)

Fusion Gene Summary for ARHGEF17-CLPB

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGEF17-CLPB
Fusion gene ID: hg9828tg81570
HgeneTgene
Gene symbol

ARHGEF17

CLPB

Gene ID

9828

81570

Gene nameRho guanine nucleotide exchange factor 17caseinolytic mitochondrial matrix peptidase chaperone subunit B
SynonymsP164RHOGEF|RHOGEF17|TEM4|p164-RhoGEFANKCLB|HSP78|MEGCANN|MGCA7|SKD3
Cytomap('ARHGEF17')('CLPB')

11q13.4

11q13.4

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 17164 kDa Rho-specific guanine-nucleotide exchange factorRho guanine nucleotide exchange factor (GEF) 17Rho-specific guanine-nucleotide exchange factor 164 kDatumor endothelial marker 4caseinolytic peptidase B protein homologClpB caseinolytic peptidase B homologClpB homolog, mitochondrial AAA ATPase chaperoninankyrin-repeat containing bacterial clp fusionsuppressor of potassium transport defect 3testicular secretory protein Li 11
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000263674, ENST00000536170, 
Fusion gene scores* DoF score9 X 3 X 5=13512 X 11 X 8=1056
# samples 1015
** MAII scorelog2(10/135*10)=-0.432959407276106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1056*10)=-2.81557542886257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGEF17 [Title/Abstract] AND CLPB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGEF17(73022875)-CLPB(72028264), # samples:2
Anticipated loss of major functional domain due to fusion event.ARHGEF17-CLPB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF17-CLPB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF17-CLPB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF17-CLPB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGEF17

GO:0030036

actin cytoskeleton organization

12071859

TgeneCLPB

GO:0034605

cellular response to heat

2745427


check buttonFusion gene breakpoints across ARHGEF17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CLPB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-1627-01AARHGEF17chr11

73022875

+CLPBchr11

72028264

-


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Fusion Gene ORF analysis for ARHGEF17-CLPB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263674ENST00000445069ARHGEF17chr11

73022875

+CLPBchr11

72028264

-
5CDS-intronENST00000263674ENST00000538021ARHGEF17chr11

73022875

+CLPBchr11

72028264

-
5CDS-intronENST00000263674ENST00000542555ARHGEF17chr11

73022875

+CLPBchr11

72028264

-
In-frameENST00000263674ENST00000294053ARHGEF17chr11

73022875

+CLPBchr11

72028264

-
In-frameENST00000263674ENST00000340729ARHGEF17chr11

73022875

+CLPBchr11

72028264

-
In-frameENST00000263674ENST00000437826ARHGEF17chr11

73022875

+CLPBchr11

72028264

-
In-frameENST00000263674ENST00000538039ARHGEF17chr11

73022875

+CLPBchr11

72028264

-
In-frameENST00000263674ENST00000543042ARHGEF17chr11

73022875

+CLPBchr11

72028264

-
intron-3CDSENST00000536170ENST00000294053ARHGEF17chr11

73022875

+CLPBchr11

72028264

-
intron-3CDSENST00000536170ENST00000340729ARHGEF17chr11

73022875

+CLPBchr11

72028264

-
intron-3CDSENST00000536170ENST00000437826ARHGEF17chr11

73022875

+CLPBchr11

72028264

-
intron-3CDSENST00000536170ENST00000538039ARHGEF17chr11

73022875

+CLPBchr11

72028264

-
intron-3CDSENST00000536170ENST00000543042ARHGEF17chr11

73022875

+CLPBchr11

72028264

-
intron-intronENST00000536170ENST00000445069ARHGEF17chr11

73022875

+CLPBchr11

72028264

-
intron-intronENST00000536170ENST00000538021ARHGEF17chr11

73022875

+CLPBchr11

72028264

-
intron-intronENST00000536170ENST00000542555ARHGEF17chr11

73022875

+CLPBchr11

72028264

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263674ARHGEF17chr1173022875+ENST00000294053CLPBchr1172028264-5645354220947021497
ENST00000263674ARHGEF17chr1173022875+ENST00000538039CLPBchr1172028264-5624354220947021497
ENST00000263674ARHGEF17chr1173022875+ENST00000437826CLPBchr1172028264-4767354220947021497
ENST00000263674ARHGEF17chr1173022875+ENST00000340729CLPBchr1172028264-4767354220947021497
ENST00000263674ARHGEF17chr1173022875+ENST00000543042CLPBchr1172028264-4761354220947021497

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263674ENST00000294053ARHGEF17chr1173022875+CLPBchr1172028264-0.0112176030.98878235
ENST00000263674ENST00000538039ARHGEF17chr1173022875+CLPBchr1172028264-0.0113677970.98863226
ENST00000263674ENST00000437826ARHGEF17chr1173022875+CLPBchr1172028264-0.0140104630.9859896
ENST00000263674ENST00000340729ARHGEF17chr1173022875+CLPBchr1172028264-0.0140104630.9859896
ENST00000263674ENST00000543042ARHGEF17chr1173022875+CLPBchr1172028264-0.0136593540.98634064

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Fusion Genomic Features for ARHGEF17-CLPB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ARHGEF17-CLPB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:73022875/chr11:72028264)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF17chr11:73022875chr11:72028264ENST00000263674+121201_20410642064.0Compositional biasNote=Poly-Gln
HgeneARHGEF17chr11:73022875chr11:72028264ENST00000263674+121230_23510642064.0Compositional biasNote=Poly-Ser
HgeneARHGEF17chr11:73022875chr11:72028264ENST00000263674+121252_25610642064.0Compositional biasNote=Poly-Glu
HgeneARHGEF17chr11:73022875chr11:72028264ENST00000263674+121566_56910642064.0Compositional biasNote=Poly-Ser
HgeneARHGEF17chr11:73022875chr11:72028264ENST00000263674+121672_67510642064.0Compositional biasNote=Poly-Ser
HgeneARHGEF17chr11:73022875chr11:72028264ENST00000263674+121707_71010642064.0Compositional biasNote=Poly-Arg
HgeneARHGEF17chr11:73022875chr11:72028264ENST00000263674+121963_105410642064.0Compositional biasNote=Pro-rich
TgeneCLPBchr11:73022875chr11:72028264ENST00000294053617381_388321708.0Nucleotide bindingATP
TgeneCLPBchr11:73022875chr11:72028264ENST00000340729415381_388262649.0Nucleotide bindingATP
TgeneCLPBchr11:73022875chr11:72028264ENST00000437826718381_388276663.0Nucleotide bindingATP
TgeneCLPBchr11:73022875chr11:72028264ENST00000538039516381_388291678.0Nucleotide bindingATP
TgeneCLPBchr11:73022875chr11:72028264ENST00000340729415265_295262649.0RepeatNote=ANK 3
TgeneCLPBchr11:73022875chr11:72028264ENST00000340729415298_327262649.0RepeatNote=ANK 4
TgeneCLPBchr11:73022875chr11:72028264ENST00000437826718298_327276663.0RepeatNote=ANK 4
TgeneCLPBchr11:73022875chr11:72028264ENST00000538039516298_327291678.0RepeatNote=ANK 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF17chr11:73022875chr11:72028264ENST00000263674+1211990_199610642064.0Compositional biasNote=Poly-Pro
HgeneARHGEF17chr11:73022875chr11:72028264ENST00000263674+1211066_125410642064.0DomainDH
TgeneCLPBchr11:73022875chr11:72028264ENST00000294053617133_162321708.0RepeatNote=ANK 1
TgeneCLPBchr11:73022875chr11:72028264ENST00000294053617166_195321708.0RepeatNote=ANK 2
TgeneCLPBchr11:73022875chr11:72028264ENST00000294053617265_295321708.0RepeatNote=ANK 3
TgeneCLPBchr11:73022875chr11:72028264ENST00000294053617298_327321708.0RepeatNote=ANK 4
TgeneCLPBchr11:73022875chr11:72028264ENST00000340729415133_162262649.0RepeatNote=ANK 1
TgeneCLPBchr11:73022875chr11:72028264ENST00000340729415166_195262649.0RepeatNote=ANK 2
TgeneCLPBchr11:73022875chr11:72028264ENST00000437826718133_162276663.0RepeatNote=ANK 1
TgeneCLPBchr11:73022875chr11:72028264ENST00000437826718166_195276663.0RepeatNote=ANK 2
TgeneCLPBchr11:73022875chr11:72028264ENST00000437826718265_295276663.0RepeatNote=ANK 3
TgeneCLPBchr11:73022875chr11:72028264ENST00000538039516133_162291678.0RepeatNote=ANK 1
TgeneCLPBchr11:73022875chr11:72028264ENST00000538039516166_195291678.0RepeatNote=ANK 2
TgeneCLPBchr11:73022875chr11:72028264ENST00000538039516265_295291678.0RepeatNote=ANK 3


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Fusion Gene Sequence for ARHGEF17-CLPB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6226_6226_1_ARHGEF17-CLPB_ARHGEF17_chr11_73022875_ENST00000263674_CLPB_chr11_72028264_ENST00000294053_length(transcript)=5645nt_BP=3542nt
GAGCGAGCAGCCAAGGGCGTTGGGCAGGCGGACGCAGAGTCGAGGAACCAAGCGCTGGGATCCCGCCCAGGCGGTGCCGCGGTGCCCCTG
GTCGCTCCAGCCGCGGCGGGGGCTGGGCCTGGGGGTCGGCGCTGAGGCGGGAGGGGCCGCCCGGGATGGAGACGTTGCGGCCGGTGGCCA
CAGAAACTTGAGCCGCGGCAGAGAAACCTCTGCTCCGGTCTCTGCGTCCTCTTCCCACACTCCCGTGCGCTGCTTTCGGCGTGGGCCGCT
GCGCTCCTAGGGAGTGGGGGCGCAGGGGGGGTTGGCCGCGGCTGCCCGAGGCCAGCCCCCCCGGAGTGAGTTACGCCACTATGGCGGACG
GGGCACCCCGGCCCCAGCTTTACCGCAGCGTCTCGTTCAAGCTGCTGGAGCGCTGGAGCGGCGGCCCCGGGCTGAGGGAGGAGGACACGG
ACACCCCCGGCTTGAGGCGACGCGCCTCGTGCCGGCCGACCACGGCTGCCCGGGGCCAGCCCTCTCGGCGCGTGTCCAAGCTGGCGTCTG
GGCCCCTGGCCGCCCCCGCGCAGCCGCGCCCGCTCCGCAGCCTCTCGCCGTCGGTTCGCCAGCTCTCCCGGCGCTTCGACGCGCCGCGTC
TGGACGACGGCTCCGCTGGGACCCGAGACGGAGGCGTCTTACCCGCGGCCGCGGAAGAAGCGGCCGAGGGCCCAGCGCGAGGAGCCTGGC
CCAGCGTCACCGAGATGCGCAAGCTCTTCGGCGGTCCTGGCTCCAGGAGGCCCAGCGCCGACTCTGAATCCCCAGGAACGCCCAGCCCCG
ACGGTGCCGCGTGGGAGCCTCCGGCTCGGGAGTCGCGGCAGCCACCGACGCCACCCCCTCGGACATGCTTCCCCCTGGCGGGTCTGCGTT
CGGCGCGGCCCCTGACCGGGCCGGAGACCGAAGGGAGGCTGCGCCGGCCGCAGCAGCAACAGGAGCGGGCGCAGCGTCCAGCGGATGGTT
TACATTCTTGGCATATCTTCTCCCAACCGCAGGCCGGGGCCCGGGCCTCCTGCTCCTCCTCCTCCATCGCCGCCTCCTATCCTGTCAGCC
GCAGTCGTGCTGCCAGCTCCAGCGAGGAGGAAGAGGAGGGCCCGCCGCAGCTGCCTGGAGCCCAGAGTCCGGCCTACCACGGCGGCCACT
CCTCGGGCAGTGACGACGACCGAGACGGTGAGGGCGGCCACCGCTGGGGAGGGAGGCCCGGGCTCAGGCCTGGAAGCTCCCTATTGGATC
AGGACTGCAGGCCTGACAGTGATGGGTTAAATCTAAGCAGCATGAACTCAGCAGGGGTTTCTGGGAGCCCTGAGCCCCCAACATCTCCAA
GAGCCCCTAGAGAAGAAGGACTCCGGGAGTGGGGTAGTGGCTCTCCGCCCTGCGTCCCAGGTCCCCAGGAGGGACTTCGGCCTATGTCTG
ACTCTGTGGGAGGAGCTTTCCGTGTGGCCAAGGTGAGCTTTCCCTCGTACCTGGCCAGCCCCGCAGGCTCCCGCGGTAGCAGCCGTTATT
CCAGCACGGAGACCCTCAAGGACGACGACCTATGGTCTAGTAGGGGTTCTGGGGGCTGGGGCGTGTACCGCTCCCCTAGCTTTGGAGCTG
GGGAAGGGCTCCTGCGGTCCCAGGCTCGAACCCGTGCCAAAGGACCTGGAGGCACCTCTAGGGCATTGAGGGATGGAGGATTTGAGCCTG
AAAAGAGTCGACAGCGGAAGTCCCTGTCAAATCCAGATATCGCCTCAGAGACCCTGACGCTTCTCAGTTTCCTGCGCTCAGACCTTTCAG
AGCTGAGGGTCCGAAAACCTGGTGGGAGCTCCGGGGACCGTGGAAGCAACCCCCTAGATGGCAGAGACTCACCATCCGCAGGTGGCCCTG
TGGGGCAACTTGAACCCATACCCATCCCAGCCCCAGCATCACCTGGCACGCGCCCCACACTCAAGGACTTGACAGCCACTCTGCGGAGAG
CAAAGTCATTCACCTGCTCTGAGAAGCCCATGGCCCGCCGCCTGCCCCGCACCAGTGCTCTGAAGTCCAGCTCCTCCGAGCTCCTGCTCA
CAGGCCCTGGTGCCGAGGAGGATCCGCTGCCCCTCATCGTCCAGGACCAATATGTGCAGGAGGCCCGCCAGGTTTTTGAGAAGATCCAGC
GCATGGGTGCCCAACAAGATGATGGAAGCGATGCCCCCCCTGGAAGCCCTGACTGGGCAGGGGATGTGACCCGAGGGCAGCGGTCCCAGG
AGGAGCTCTCAGGCCCTGAGTCCAGTCTGACAGATGAAGGCATTGGGGCAGACCCTGAGCCTCCTGTTGCAGCATTTTGCGGCCTGGGTA
CCACAGGGATGTGGCGACCTCTTTCCTCATCCTCGGCCCAGACGAACCACCATGGCCCTGGGACTGAGGACAGTCTGGGCGGGTGGGCCC
TGGTGTCGCCTGAGACCCCTCCCACACCAGGTGCCCTCCGCCGACGACGCAAAGTCCCACCTTCAGGTTCTGGTGGGAGCGAATTGAGCA
ATGGGGAGGCAGGGGAGGCCTACAGGTCCCTGAGTGACCCAATTCCTCAGCGCCACCGGGCTGCCACCTCTGAAGAGCCTACTGGGTTCT
CTGTGGACAGCAACCTCCTGGGCTCACTGAGCCCCAAGACAGGGCTCCCTGCCACCTCAGCCATGGATGAGGGCTTGACCAGTGGTCACA
GTGACTGGTCTGTGGGCAGTGAAGAGAGCAAGGGATATCAGGAGGTTATTCAGAGCATAGTTCAGGGGCCTGGCACCCTGGGGCGTGTGG
TGGACGACAGGATTGCTGGCAAAGCCCCCAAGAAGAAATCCCTGAGTGACCCCAGCCGCCGTGGGGAGCTGGCTGGGCCTGGATTCGAGG
GCCCTGGAGGGGAGCCCATCCGAGAAGTTGAGCCCATGCTGCCTCCATCCAGCAGCGAGCCCATCCTTGTAGAGCAGCGGGCAGAGCCAG
AAGAACCTGGTGCCACCAGGAGCCGGGCACAGTCTGAAAGGGCCCTACCTGAGGCTCTGCCTCCCCCTGCCACTGCCCACCGAAACTTTC
ACCTTGACCCCAAGCTGGCTGACATTCTGTCCCCGAGGCTAATCCGCCGAGGCTCCAAGAAGCGCCCAGCTCGGAGTAGTCACCAGGAGC
TTCGGAGAGACGAGGGCAGTCAGGACCAGACTGGCAGCCTGTCTCGGGCCCGGCCCTCCTCCAGACACGTTCGCCATGCCAGTGTGCCCG
CCACATTTATGCCTATTGTGGTGCCTGAGCCACCAACTTCTGTTGGTCCCCCTGTGGCTGTGCCAGAACCCATAGGCTTCCCTACCCGAG
CCCATCCCACGTTGCAGGCACCATCGCTCGAGGACGTCACCAAGCAGTACATGCTGAACCTGCACTCCGGTGAGGTCCCTGCCCCAGTGC
CAGTGGACATGCCCTGCTTGCCTCTGGCTGCACCGCCCTCTGCTGAGGCCAAGCCCCCTGAGGCAGCTCGGCCTGCAGATGAGCCTACCC
CTGCCAGCAAGTGCTGCAGCAAGCCACAGGTGTACCAAGAGAAGCAGCGGAAGCGTGAGGCTGAGGAGCGGCGCCGCTTCCCCCTGGAGC
AGCGACTAAAGGAGCACATCATTGGCCAGGAGAGCGCCATCGCCACAGTGGGTGCTGCGATCCGGAGGAAGGAGAATGGCTGGTACGATG
AAGAACACCCTCTGGTCTTCCTCTTCTTGGGATCATCTGGAATAGGAAAAACAGAGCTGGCCAAGCAGACAGCCAAATATATGCACAAAG
ATGCTAAAAAGGGCTTCATCAGGCTGGACATGTCCGAGTTCCAGGAGCGACACGAGGTGGCCAAGTTTATTGGGTCTCCACCAGGCTACG
TTGGCCATGAGGAGGGTGGCCAGCTGACCAAGAAGTTGAAGCAGTGCCCCAATGCTGTGGTGCTCTTTGATGAAGTAGACAAGGCCCATC
CAGATGTGCTCACCATCATGCTGCAGCTGTTTGATGAGGGCCGGCTGACAGATGGAAAAGGGAAGACCATTGATTGCAAGGACGCCATCT
TCATCATGACCTCCAATGTGGCCAGCGACGAGATCGCACAGCACGCGCTGCAGCTGAGGCAGGAAGCTTTGGAGATGAGCCGTAACCGTA
TTGCCGAAAACCTGGGGGATGTCCAGATAAGTGACAAGATCACCATCTCAAAGAACTTCAAGGAGAATGTGATTCGCCCTATCCTGAAAG
CTCACTTCCGGAGGGATGAGTTTCTGGGACGGATCAATGAGATCGTCTACTTCCTCCCCTTCTGCCACTCGGAGCTCATCCAACTCGTCA
ACAAGGAACTAAACTTCTGGGCCAAGAGAGCCAAGCAAAGGCACAACATCACGCTGCTCTGGGACCGCGAGGTGGCAGATGTGCTGGTCG
ACGGCTACAATGTGCACTATGGCGCCCGCTCCATCAAACATGAGGTAGAACGCCGTGTGGTGAACCAGCTGGCAGCAGCCTATGAGCAGG
ACCTGCTGCCAGGGGGCTGTACTTTGCGCATCACGGTGGAGGACTCAGACAAGCAGCTACTCAAAAGCCCAGAACTGCCCTCACCCCAGG
CTGAGAAGCGCCTCCCCAAGCTGCGTCTGGAGATCATCGACAAGGACAGCAAGACTCGCAGACTGGACATCCGGGCACCACTGCACCCTG
AGAAGGTGTGCAACACCATCTAGCAGCCACCTGCCTGCTCCTATGTGCCCTCACCATCCAATAAAGGCCCCTTGGCTGTGGCATGGCAAC
TGACTTACCTTCCCCTCATGCCGCTCCCATCTCTACCCAGTCTCAGGCCTGCTTACCTCCTCACAGCCCATGAAGACCCCTTCTCAGCCC
CAAAACCTGAAGGAGGAATTTCGCCCTACTCTGGCCCCTTTGTTGTGGGCCCATAACCTGCTAACAAGCCTTCAGGAGAGGAGCTGCCTT
TCCACCCCCTTCAAGGCAAGGAGGGATGGAGGTCCCTTATTTCCTTCAGAATGATCCCCATCCCCCATAGTCGCCAGACTTTCTCATGTT
CCCAGGAAGCTCAGAAGTATGGCAGCTAAGAACACAGCTGGCTGGAAGAAGACAGGGACCAGACTGAACTGCCACCCTCTGCTAGTCCTC
ATGCAACTCAGTCCCCAGAATGGCTCCACTGGGAGTGGAGGAAGAGCTCAGAGGCCCAGGTGCAGATAGTTCTGCAATTTAGTCTGTAGC
CTCCTCGTTCCCTACCCTAAAATTCTAAGGGGAAGGGACCCATAGAGGCTTGCCTGTTTCCGCTACTATATTATGCCCAGTGTTCCTCCT
CACCCCACGTCCTGGGGTCAGGCCAGACCATGTTTCGTCAGCCTTGGGGACTAGGCCAGTGTTGGGCACCTCCAGGAGGAGGCCTGACTG
GTTCATTACCCTCCCCTACTCAGACTGAGCAGCAGTCCCAGATAACCAAGCAAGCTCAGCTCTGTGGGGGCCTCCTTCAAAAGACCAACA
TCGCAGACATTAGGAAGCTGTAGGAAGAGAGATCATGGGTTTGACCTCTGCCCACATGGCCATGGAGTCAGCCTCAGCCCTGTCTGTACT

>6226_6226_1_ARHGEF17-CLPB_ARHGEF17_chr11_73022875_ENST00000263674_CLPB_chr11_72028264_ENST00000294053_length(amino acids)=1497AA_BP=1111
MLRSLRPLPTLPCAAFGVGRCAPREWGRRGGWPRLPEASPPGVSYATMADGAPRPQLYRSVSFKLLERWSGGPGLREEDTDTPGLRRRAS
CRPTTAARGQPSRRVSKLASGPLAAPAQPRPLRSLSPSVRQLSRRFDAPRLDDGSAGTRDGGVLPAAAEEAAEGPARGAWPSVTEMRKLF
GGPGSRRPSADSESPGTPSPDGAAWEPPARESRQPPTPPPRTCFPLAGLRSARPLTGPETEGRLRRPQQQQERAQRPADGLHSWHIFSQP
QAGARASCSSSSIAASYPVSRSRAASSSEEEEEGPPQLPGAQSPAYHGGHSSGSDDDRDGEGGHRWGGRPGLRPGSSLLDQDCRPDSDGL
NLSSMNSAGVSGSPEPPTSPRAPREEGLREWGSGSPPCVPGPQEGLRPMSDSVGGAFRVAKVSFPSYLASPAGSRGSSRYSSTETLKDDD
LWSSRGSGGWGVYRSPSFGAGEGLLRSQARTRAKGPGGTSRALRDGGFEPEKSRQRKSLSNPDIASETLTLLSFLRSDLSELRVRKPGGS
SGDRGSNPLDGRDSPSAGGPVGQLEPIPIPAPASPGTRPTLKDLTATLRRAKSFTCSEKPMARRLPRTSALKSSSSELLLTGPGAEEDPL
PLIVQDQYVQEARQVFEKIQRMGAQQDDGSDAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSS
SSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGSELSNGEAGEAYRSLSDPIPQRHRAATSEEPTGFSVDSNLLGSL
SPKTGLPATSAMDEGLTSGHSDWSVGSEESKGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIREV
EPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNFHLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQ
TGSLSRARPSSRHVRHASVPATFMPIVVPEPPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLA
APPSAEAKPPEAARPADEPTPASKCCSKPQVYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFL
GSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQL
FDEGRLTDGKGKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKENVIRPILKAHFRRDEFLG
RINEIVYFLPFCHSELIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLR

--------------------------------------------------------------
>6226_6226_2_ARHGEF17-CLPB_ARHGEF17_chr11_73022875_ENST00000263674_CLPB_chr11_72028264_ENST00000340729_length(transcript)=4767nt_BP=3542nt
GAGCGAGCAGCCAAGGGCGTTGGGCAGGCGGACGCAGAGTCGAGGAACCAAGCGCTGGGATCCCGCCCAGGCGGTGCCGCGGTGCCCCTG
GTCGCTCCAGCCGCGGCGGGGGCTGGGCCTGGGGGTCGGCGCTGAGGCGGGAGGGGCCGCCCGGGATGGAGACGTTGCGGCCGGTGGCCA
CAGAAACTTGAGCCGCGGCAGAGAAACCTCTGCTCCGGTCTCTGCGTCCTCTTCCCACACTCCCGTGCGCTGCTTTCGGCGTGGGCCGCT
GCGCTCCTAGGGAGTGGGGGCGCAGGGGGGGTTGGCCGCGGCTGCCCGAGGCCAGCCCCCCCGGAGTGAGTTACGCCACTATGGCGGACG
GGGCACCCCGGCCCCAGCTTTACCGCAGCGTCTCGTTCAAGCTGCTGGAGCGCTGGAGCGGCGGCCCCGGGCTGAGGGAGGAGGACACGG
ACACCCCCGGCTTGAGGCGACGCGCCTCGTGCCGGCCGACCACGGCTGCCCGGGGCCAGCCCTCTCGGCGCGTGTCCAAGCTGGCGTCTG
GGCCCCTGGCCGCCCCCGCGCAGCCGCGCCCGCTCCGCAGCCTCTCGCCGTCGGTTCGCCAGCTCTCCCGGCGCTTCGACGCGCCGCGTC
TGGACGACGGCTCCGCTGGGACCCGAGACGGAGGCGTCTTACCCGCGGCCGCGGAAGAAGCGGCCGAGGGCCCAGCGCGAGGAGCCTGGC
CCAGCGTCACCGAGATGCGCAAGCTCTTCGGCGGTCCTGGCTCCAGGAGGCCCAGCGCCGACTCTGAATCCCCAGGAACGCCCAGCCCCG
ACGGTGCCGCGTGGGAGCCTCCGGCTCGGGAGTCGCGGCAGCCACCGACGCCACCCCCTCGGACATGCTTCCCCCTGGCGGGTCTGCGTT
CGGCGCGGCCCCTGACCGGGCCGGAGACCGAAGGGAGGCTGCGCCGGCCGCAGCAGCAACAGGAGCGGGCGCAGCGTCCAGCGGATGGTT
TACATTCTTGGCATATCTTCTCCCAACCGCAGGCCGGGGCCCGGGCCTCCTGCTCCTCCTCCTCCATCGCCGCCTCCTATCCTGTCAGCC
GCAGTCGTGCTGCCAGCTCCAGCGAGGAGGAAGAGGAGGGCCCGCCGCAGCTGCCTGGAGCCCAGAGTCCGGCCTACCACGGCGGCCACT
CCTCGGGCAGTGACGACGACCGAGACGGTGAGGGCGGCCACCGCTGGGGAGGGAGGCCCGGGCTCAGGCCTGGAAGCTCCCTATTGGATC
AGGACTGCAGGCCTGACAGTGATGGGTTAAATCTAAGCAGCATGAACTCAGCAGGGGTTTCTGGGAGCCCTGAGCCCCCAACATCTCCAA
GAGCCCCTAGAGAAGAAGGACTCCGGGAGTGGGGTAGTGGCTCTCCGCCCTGCGTCCCAGGTCCCCAGGAGGGACTTCGGCCTATGTCTG
ACTCTGTGGGAGGAGCTTTCCGTGTGGCCAAGGTGAGCTTTCCCTCGTACCTGGCCAGCCCCGCAGGCTCCCGCGGTAGCAGCCGTTATT
CCAGCACGGAGACCCTCAAGGACGACGACCTATGGTCTAGTAGGGGTTCTGGGGGCTGGGGCGTGTACCGCTCCCCTAGCTTTGGAGCTG
GGGAAGGGCTCCTGCGGTCCCAGGCTCGAACCCGTGCCAAAGGACCTGGAGGCACCTCTAGGGCATTGAGGGATGGAGGATTTGAGCCTG
AAAAGAGTCGACAGCGGAAGTCCCTGTCAAATCCAGATATCGCCTCAGAGACCCTGACGCTTCTCAGTTTCCTGCGCTCAGACCTTTCAG
AGCTGAGGGTCCGAAAACCTGGTGGGAGCTCCGGGGACCGTGGAAGCAACCCCCTAGATGGCAGAGACTCACCATCCGCAGGTGGCCCTG
TGGGGCAACTTGAACCCATACCCATCCCAGCCCCAGCATCACCTGGCACGCGCCCCACACTCAAGGACTTGACAGCCACTCTGCGGAGAG
CAAAGTCATTCACCTGCTCTGAGAAGCCCATGGCCCGCCGCCTGCCCCGCACCAGTGCTCTGAAGTCCAGCTCCTCCGAGCTCCTGCTCA
CAGGCCCTGGTGCCGAGGAGGATCCGCTGCCCCTCATCGTCCAGGACCAATATGTGCAGGAGGCCCGCCAGGTTTTTGAGAAGATCCAGC
GCATGGGTGCCCAACAAGATGATGGAAGCGATGCCCCCCCTGGAAGCCCTGACTGGGCAGGGGATGTGACCCGAGGGCAGCGGTCCCAGG
AGGAGCTCTCAGGCCCTGAGTCCAGTCTGACAGATGAAGGCATTGGGGCAGACCCTGAGCCTCCTGTTGCAGCATTTTGCGGCCTGGGTA
CCACAGGGATGTGGCGACCTCTTTCCTCATCCTCGGCCCAGACGAACCACCATGGCCCTGGGACTGAGGACAGTCTGGGCGGGTGGGCCC
TGGTGTCGCCTGAGACCCCTCCCACACCAGGTGCCCTCCGCCGACGACGCAAAGTCCCACCTTCAGGTTCTGGTGGGAGCGAATTGAGCA
ATGGGGAGGCAGGGGAGGCCTACAGGTCCCTGAGTGACCCAATTCCTCAGCGCCACCGGGCTGCCACCTCTGAAGAGCCTACTGGGTTCT
CTGTGGACAGCAACCTCCTGGGCTCACTGAGCCCCAAGACAGGGCTCCCTGCCACCTCAGCCATGGATGAGGGCTTGACCAGTGGTCACA
GTGACTGGTCTGTGGGCAGTGAAGAGAGCAAGGGATATCAGGAGGTTATTCAGAGCATAGTTCAGGGGCCTGGCACCCTGGGGCGTGTGG
TGGACGACAGGATTGCTGGCAAAGCCCCCAAGAAGAAATCCCTGAGTGACCCCAGCCGCCGTGGGGAGCTGGCTGGGCCTGGATTCGAGG
GCCCTGGAGGGGAGCCCATCCGAGAAGTTGAGCCCATGCTGCCTCCATCCAGCAGCGAGCCCATCCTTGTAGAGCAGCGGGCAGAGCCAG
AAGAACCTGGTGCCACCAGGAGCCGGGCACAGTCTGAAAGGGCCCTACCTGAGGCTCTGCCTCCCCCTGCCACTGCCCACCGAAACTTTC
ACCTTGACCCCAAGCTGGCTGACATTCTGTCCCCGAGGCTAATCCGCCGAGGCTCCAAGAAGCGCCCAGCTCGGAGTAGTCACCAGGAGC
TTCGGAGAGACGAGGGCAGTCAGGACCAGACTGGCAGCCTGTCTCGGGCCCGGCCCTCCTCCAGACACGTTCGCCATGCCAGTGTGCCCG
CCACATTTATGCCTATTGTGGTGCCTGAGCCACCAACTTCTGTTGGTCCCCCTGTGGCTGTGCCAGAACCCATAGGCTTCCCTACCCGAG
CCCATCCCACGTTGCAGGCACCATCGCTCGAGGACGTCACCAAGCAGTACATGCTGAACCTGCACTCCGGTGAGGTCCCTGCCCCAGTGC
CAGTGGACATGCCCTGCTTGCCTCTGGCTGCACCGCCCTCTGCTGAGGCCAAGCCCCCTGAGGCAGCTCGGCCTGCAGATGAGCCTACCC
CTGCCAGCAAGTGCTGCAGCAAGCCACAGGTGTACCAAGAGAAGCAGCGGAAGCGTGAGGCTGAGGAGCGGCGCCGCTTCCCCCTGGAGC
AGCGACTAAAGGAGCACATCATTGGCCAGGAGAGCGCCATCGCCACAGTGGGTGCTGCGATCCGGAGGAAGGAGAATGGCTGGTACGATG
AAGAACACCCTCTGGTCTTCCTCTTCTTGGGATCATCTGGAATAGGAAAAACAGAGCTGGCCAAGCAGACAGCCAAATATATGCACAAAG
ATGCTAAAAAGGGCTTCATCAGGCTGGACATGTCCGAGTTCCAGGAGCGACACGAGGTGGCCAAGTTTATTGGGTCTCCACCAGGCTACG
TTGGCCATGAGGAGGGTGGCCAGCTGACCAAGAAGTTGAAGCAGTGCCCCAATGCTGTGGTGCTCTTTGATGAAGTAGACAAGGCCCATC
CAGATGTGCTCACCATCATGCTGCAGCTGTTTGATGAGGGCCGGCTGACAGATGGAAAAGGGAAGACCATTGATTGCAAGGACGCCATCT
TCATCATGACCTCCAATGTGGCCAGCGACGAGATCGCACAGCACGCGCTGCAGCTGAGGCAGGAAGCTTTGGAGATGAGCCGTAACCGTA
TTGCCGAAAACCTGGGGGATGTCCAGATAAGTGACAAGATCACCATCTCAAAGAACTTCAAGGAGAATGTGATTCGCCCTATCCTGAAAG
CTCACTTCCGGAGGGATGAGTTTCTGGGACGGATCAATGAGATCGTCTACTTCCTCCCCTTCTGCCACTCGGAGCTCATCCAACTCGTCA
ACAAGGAACTAAACTTCTGGGCCAAGAGAGCCAAGCAAAGGCACAACATCACGCTGCTCTGGGACCGCGAGGTGGCAGATGTGCTGGTCG
ACGGCTACAATGTGCACTATGGCGCCCGCTCCATCAAACATGAGGTAGAACGCCGTGTGGTGAACCAGCTGGCAGCAGCCTATGAGCAGG
ACCTGCTGCCAGGGGGCTGTACTTTGCGCATCACGGTGGAGGACTCAGACAAGCAGCTACTCAAAAGCCCAGAACTGCCCTCACCCCAGG
CTGAGAAGCGCCTCCCCAAGCTGCGTCTGGAGATCATCGACAAGGACAGCAAGACTCGCAGACTGGACATCCGGGCACCACTGCACCCTG

>6226_6226_2_ARHGEF17-CLPB_ARHGEF17_chr11_73022875_ENST00000263674_CLPB_chr11_72028264_ENST00000340729_length(amino acids)=1497AA_BP=1111
MLRSLRPLPTLPCAAFGVGRCAPREWGRRGGWPRLPEASPPGVSYATMADGAPRPQLYRSVSFKLLERWSGGPGLREEDTDTPGLRRRAS
CRPTTAARGQPSRRVSKLASGPLAAPAQPRPLRSLSPSVRQLSRRFDAPRLDDGSAGTRDGGVLPAAAEEAAEGPARGAWPSVTEMRKLF
GGPGSRRPSADSESPGTPSPDGAAWEPPARESRQPPTPPPRTCFPLAGLRSARPLTGPETEGRLRRPQQQQERAQRPADGLHSWHIFSQP
QAGARASCSSSSIAASYPVSRSRAASSSEEEEEGPPQLPGAQSPAYHGGHSSGSDDDRDGEGGHRWGGRPGLRPGSSLLDQDCRPDSDGL
NLSSMNSAGVSGSPEPPTSPRAPREEGLREWGSGSPPCVPGPQEGLRPMSDSVGGAFRVAKVSFPSYLASPAGSRGSSRYSSTETLKDDD
LWSSRGSGGWGVYRSPSFGAGEGLLRSQARTRAKGPGGTSRALRDGGFEPEKSRQRKSLSNPDIASETLTLLSFLRSDLSELRVRKPGGS
SGDRGSNPLDGRDSPSAGGPVGQLEPIPIPAPASPGTRPTLKDLTATLRRAKSFTCSEKPMARRLPRTSALKSSSSELLLTGPGAEEDPL
PLIVQDQYVQEARQVFEKIQRMGAQQDDGSDAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSS
SSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGSELSNGEAGEAYRSLSDPIPQRHRAATSEEPTGFSVDSNLLGSL
SPKTGLPATSAMDEGLTSGHSDWSVGSEESKGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIREV
EPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNFHLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQ
TGSLSRARPSSRHVRHASVPATFMPIVVPEPPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLA
APPSAEAKPPEAARPADEPTPASKCCSKPQVYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFL
GSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQL
FDEGRLTDGKGKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKENVIRPILKAHFRRDEFLG
RINEIVYFLPFCHSELIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLR

--------------------------------------------------------------
>6226_6226_3_ARHGEF17-CLPB_ARHGEF17_chr11_73022875_ENST00000263674_CLPB_chr11_72028264_ENST00000437826_length(transcript)=4767nt_BP=3542nt
GAGCGAGCAGCCAAGGGCGTTGGGCAGGCGGACGCAGAGTCGAGGAACCAAGCGCTGGGATCCCGCCCAGGCGGTGCCGCGGTGCCCCTG
GTCGCTCCAGCCGCGGCGGGGGCTGGGCCTGGGGGTCGGCGCTGAGGCGGGAGGGGCCGCCCGGGATGGAGACGTTGCGGCCGGTGGCCA
CAGAAACTTGAGCCGCGGCAGAGAAACCTCTGCTCCGGTCTCTGCGTCCTCTTCCCACACTCCCGTGCGCTGCTTTCGGCGTGGGCCGCT
GCGCTCCTAGGGAGTGGGGGCGCAGGGGGGGTTGGCCGCGGCTGCCCGAGGCCAGCCCCCCCGGAGTGAGTTACGCCACTATGGCGGACG
GGGCACCCCGGCCCCAGCTTTACCGCAGCGTCTCGTTCAAGCTGCTGGAGCGCTGGAGCGGCGGCCCCGGGCTGAGGGAGGAGGACACGG
ACACCCCCGGCTTGAGGCGACGCGCCTCGTGCCGGCCGACCACGGCTGCCCGGGGCCAGCCCTCTCGGCGCGTGTCCAAGCTGGCGTCTG
GGCCCCTGGCCGCCCCCGCGCAGCCGCGCCCGCTCCGCAGCCTCTCGCCGTCGGTTCGCCAGCTCTCCCGGCGCTTCGACGCGCCGCGTC
TGGACGACGGCTCCGCTGGGACCCGAGACGGAGGCGTCTTACCCGCGGCCGCGGAAGAAGCGGCCGAGGGCCCAGCGCGAGGAGCCTGGC
CCAGCGTCACCGAGATGCGCAAGCTCTTCGGCGGTCCTGGCTCCAGGAGGCCCAGCGCCGACTCTGAATCCCCAGGAACGCCCAGCCCCG
ACGGTGCCGCGTGGGAGCCTCCGGCTCGGGAGTCGCGGCAGCCACCGACGCCACCCCCTCGGACATGCTTCCCCCTGGCGGGTCTGCGTT
CGGCGCGGCCCCTGACCGGGCCGGAGACCGAAGGGAGGCTGCGCCGGCCGCAGCAGCAACAGGAGCGGGCGCAGCGTCCAGCGGATGGTT
TACATTCTTGGCATATCTTCTCCCAACCGCAGGCCGGGGCCCGGGCCTCCTGCTCCTCCTCCTCCATCGCCGCCTCCTATCCTGTCAGCC
GCAGTCGTGCTGCCAGCTCCAGCGAGGAGGAAGAGGAGGGCCCGCCGCAGCTGCCTGGAGCCCAGAGTCCGGCCTACCACGGCGGCCACT
CCTCGGGCAGTGACGACGACCGAGACGGTGAGGGCGGCCACCGCTGGGGAGGGAGGCCCGGGCTCAGGCCTGGAAGCTCCCTATTGGATC
AGGACTGCAGGCCTGACAGTGATGGGTTAAATCTAAGCAGCATGAACTCAGCAGGGGTTTCTGGGAGCCCTGAGCCCCCAACATCTCCAA
GAGCCCCTAGAGAAGAAGGACTCCGGGAGTGGGGTAGTGGCTCTCCGCCCTGCGTCCCAGGTCCCCAGGAGGGACTTCGGCCTATGTCTG
ACTCTGTGGGAGGAGCTTTCCGTGTGGCCAAGGTGAGCTTTCCCTCGTACCTGGCCAGCCCCGCAGGCTCCCGCGGTAGCAGCCGTTATT
CCAGCACGGAGACCCTCAAGGACGACGACCTATGGTCTAGTAGGGGTTCTGGGGGCTGGGGCGTGTACCGCTCCCCTAGCTTTGGAGCTG
GGGAAGGGCTCCTGCGGTCCCAGGCTCGAACCCGTGCCAAAGGACCTGGAGGCACCTCTAGGGCATTGAGGGATGGAGGATTTGAGCCTG
AAAAGAGTCGACAGCGGAAGTCCCTGTCAAATCCAGATATCGCCTCAGAGACCCTGACGCTTCTCAGTTTCCTGCGCTCAGACCTTTCAG
AGCTGAGGGTCCGAAAACCTGGTGGGAGCTCCGGGGACCGTGGAAGCAACCCCCTAGATGGCAGAGACTCACCATCCGCAGGTGGCCCTG
TGGGGCAACTTGAACCCATACCCATCCCAGCCCCAGCATCACCTGGCACGCGCCCCACACTCAAGGACTTGACAGCCACTCTGCGGAGAG
CAAAGTCATTCACCTGCTCTGAGAAGCCCATGGCCCGCCGCCTGCCCCGCACCAGTGCTCTGAAGTCCAGCTCCTCCGAGCTCCTGCTCA
CAGGCCCTGGTGCCGAGGAGGATCCGCTGCCCCTCATCGTCCAGGACCAATATGTGCAGGAGGCCCGCCAGGTTTTTGAGAAGATCCAGC
GCATGGGTGCCCAACAAGATGATGGAAGCGATGCCCCCCCTGGAAGCCCTGACTGGGCAGGGGATGTGACCCGAGGGCAGCGGTCCCAGG
AGGAGCTCTCAGGCCCTGAGTCCAGTCTGACAGATGAAGGCATTGGGGCAGACCCTGAGCCTCCTGTTGCAGCATTTTGCGGCCTGGGTA
CCACAGGGATGTGGCGACCTCTTTCCTCATCCTCGGCCCAGACGAACCACCATGGCCCTGGGACTGAGGACAGTCTGGGCGGGTGGGCCC
TGGTGTCGCCTGAGACCCCTCCCACACCAGGTGCCCTCCGCCGACGACGCAAAGTCCCACCTTCAGGTTCTGGTGGGAGCGAATTGAGCA
ATGGGGAGGCAGGGGAGGCCTACAGGTCCCTGAGTGACCCAATTCCTCAGCGCCACCGGGCTGCCACCTCTGAAGAGCCTACTGGGTTCT
CTGTGGACAGCAACCTCCTGGGCTCACTGAGCCCCAAGACAGGGCTCCCTGCCACCTCAGCCATGGATGAGGGCTTGACCAGTGGTCACA
GTGACTGGTCTGTGGGCAGTGAAGAGAGCAAGGGATATCAGGAGGTTATTCAGAGCATAGTTCAGGGGCCTGGCACCCTGGGGCGTGTGG
TGGACGACAGGATTGCTGGCAAAGCCCCCAAGAAGAAATCCCTGAGTGACCCCAGCCGCCGTGGGGAGCTGGCTGGGCCTGGATTCGAGG
GCCCTGGAGGGGAGCCCATCCGAGAAGTTGAGCCCATGCTGCCTCCATCCAGCAGCGAGCCCATCCTTGTAGAGCAGCGGGCAGAGCCAG
AAGAACCTGGTGCCACCAGGAGCCGGGCACAGTCTGAAAGGGCCCTACCTGAGGCTCTGCCTCCCCCTGCCACTGCCCACCGAAACTTTC
ACCTTGACCCCAAGCTGGCTGACATTCTGTCCCCGAGGCTAATCCGCCGAGGCTCCAAGAAGCGCCCAGCTCGGAGTAGTCACCAGGAGC
TTCGGAGAGACGAGGGCAGTCAGGACCAGACTGGCAGCCTGTCTCGGGCCCGGCCCTCCTCCAGACACGTTCGCCATGCCAGTGTGCCCG
CCACATTTATGCCTATTGTGGTGCCTGAGCCACCAACTTCTGTTGGTCCCCCTGTGGCTGTGCCAGAACCCATAGGCTTCCCTACCCGAG
CCCATCCCACGTTGCAGGCACCATCGCTCGAGGACGTCACCAAGCAGTACATGCTGAACCTGCACTCCGGTGAGGTCCCTGCCCCAGTGC
CAGTGGACATGCCCTGCTTGCCTCTGGCTGCACCGCCCTCTGCTGAGGCCAAGCCCCCTGAGGCAGCTCGGCCTGCAGATGAGCCTACCC
CTGCCAGCAAGTGCTGCAGCAAGCCACAGGTGTACCAAGAGAAGCAGCGGAAGCGTGAGGCTGAGGAGCGGCGCCGCTTCCCCCTGGAGC
AGCGACTAAAGGAGCACATCATTGGCCAGGAGAGCGCCATCGCCACAGTGGGTGCTGCGATCCGGAGGAAGGAGAATGGCTGGTACGATG
AAGAACACCCTCTGGTCTTCCTCTTCTTGGGATCATCTGGAATAGGAAAAACAGAGCTGGCCAAGCAGACAGCCAAATATATGCACAAAG
ATGCTAAAAAGGGCTTCATCAGGCTGGACATGTCCGAGTTCCAGGAGCGACACGAGGTGGCCAAGTTTATTGGGTCTCCACCAGGCTACG
TTGGCCATGAGGAGGGTGGCCAGCTGACCAAGAAGTTGAAGCAGTGCCCCAATGCTGTGGTGCTCTTTGATGAAGTAGACAAGGCCCATC
CAGATGTGCTCACCATCATGCTGCAGCTGTTTGATGAGGGCCGGCTGACAGATGGAAAAGGGAAGACCATTGATTGCAAGGACGCCATCT
TCATCATGACCTCCAATGTGGCCAGCGACGAGATCGCACAGCACGCGCTGCAGCTGAGGCAGGAAGCTTTGGAGATGAGCCGTAACCGTA
TTGCCGAAAACCTGGGGGATGTCCAGATAAGTGACAAGATCACCATCTCAAAGAACTTCAAGGAGAATGTGATTCGCCCTATCCTGAAAG
CTCACTTCCGGAGGGATGAGTTTCTGGGACGGATCAATGAGATCGTCTACTTCCTCCCCTTCTGCCACTCGGAGCTCATCCAACTCGTCA
ACAAGGAACTAAACTTCTGGGCCAAGAGAGCCAAGCAAAGGCACAACATCACGCTGCTCTGGGACCGCGAGGTGGCAGATGTGCTGGTCG
ACGGCTACAATGTGCACTATGGCGCCCGCTCCATCAAACATGAGGTAGAACGCCGTGTGGTGAACCAGCTGGCAGCAGCCTATGAGCAGG
ACCTGCTGCCAGGGGGCTGTACTTTGCGCATCACGGTGGAGGACTCAGACAAGCAGCTACTCAAAAGCCCAGAACTGCCCTCACCCCAGG
CTGAGAAGCGCCTCCCCAAGCTGCGTCTGGAGATCATCGACAAGGACAGCAAGACTCGCAGACTGGACATCCGGGCACCACTGCACCCTG

>6226_6226_3_ARHGEF17-CLPB_ARHGEF17_chr11_73022875_ENST00000263674_CLPB_chr11_72028264_ENST00000437826_length(amino acids)=1497AA_BP=1111
MLRSLRPLPTLPCAAFGVGRCAPREWGRRGGWPRLPEASPPGVSYATMADGAPRPQLYRSVSFKLLERWSGGPGLREEDTDTPGLRRRAS
CRPTTAARGQPSRRVSKLASGPLAAPAQPRPLRSLSPSVRQLSRRFDAPRLDDGSAGTRDGGVLPAAAEEAAEGPARGAWPSVTEMRKLF
GGPGSRRPSADSESPGTPSPDGAAWEPPARESRQPPTPPPRTCFPLAGLRSARPLTGPETEGRLRRPQQQQERAQRPADGLHSWHIFSQP
QAGARASCSSSSIAASYPVSRSRAASSSEEEEEGPPQLPGAQSPAYHGGHSSGSDDDRDGEGGHRWGGRPGLRPGSSLLDQDCRPDSDGL
NLSSMNSAGVSGSPEPPTSPRAPREEGLREWGSGSPPCVPGPQEGLRPMSDSVGGAFRVAKVSFPSYLASPAGSRGSSRYSSTETLKDDD
LWSSRGSGGWGVYRSPSFGAGEGLLRSQARTRAKGPGGTSRALRDGGFEPEKSRQRKSLSNPDIASETLTLLSFLRSDLSELRVRKPGGS
SGDRGSNPLDGRDSPSAGGPVGQLEPIPIPAPASPGTRPTLKDLTATLRRAKSFTCSEKPMARRLPRTSALKSSSSELLLTGPGAEEDPL
PLIVQDQYVQEARQVFEKIQRMGAQQDDGSDAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSS
SSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGSELSNGEAGEAYRSLSDPIPQRHRAATSEEPTGFSVDSNLLGSL
SPKTGLPATSAMDEGLTSGHSDWSVGSEESKGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIREV
EPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNFHLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQ
TGSLSRARPSSRHVRHASVPATFMPIVVPEPPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLA
APPSAEAKPPEAARPADEPTPASKCCSKPQVYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFL
GSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQL
FDEGRLTDGKGKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKENVIRPILKAHFRRDEFLG
RINEIVYFLPFCHSELIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLR

--------------------------------------------------------------
>6226_6226_4_ARHGEF17-CLPB_ARHGEF17_chr11_73022875_ENST00000263674_CLPB_chr11_72028264_ENST00000538039_length(transcript)=5624nt_BP=3542nt
GAGCGAGCAGCCAAGGGCGTTGGGCAGGCGGACGCAGAGTCGAGGAACCAAGCGCTGGGATCCCGCCCAGGCGGTGCCGCGGTGCCCCTG
GTCGCTCCAGCCGCGGCGGGGGCTGGGCCTGGGGGTCGGCGCTGAGGCGGGAGGGGCCGCCCGGGATGGAGACGTTGCGGCCGGTGGCCA
CAGAAACTTGAGCCGCGGCAGAGAAACCTCTGCTCCGGTCTCTGCGTCCTCTTCCCACACTCCCGTGCGCTGCTTTCGGCGTGGGCCGCT
GCGCTCCTAGGGAGTGGGGGCGCAGGGGGGGTTGGCCGCGGCTGCCCGAGGCCAGCCCCCCCGGAGTGAGTTACGCCACTATGGCGGACG
GGGCACCCCGGCCCCAGCTTTACCGCAGCGTCTCGTTCAAGCTGCTGGAGCGCTGGAGCGGCGGCCCCGGGCTGAGGGAGGAGGACACGG
ACACCCCCGGCTTGAGGCGACGCGCCTCGTGCCGGCCGACCACGGCTGCCCGGGGCCAGCCCTCTCGGCGCGTGTCCAAGCTGGCGTCTG
GGCCCCTGGCCGCCCCCGCGCAGCCGCGCCCGCTCCGCAGCCTCTCGCCGTCGGTTCGCCAGCTCTCCCGGCGCTTCGACGCGCCGCGTC
TGGACGACGGCTCCGCTGGGACCCGAGACGGAGGCGTCTTACCCGCGGCCGCGGAAGAAGCGGCCGAGGGCCCAGCGCGAGGAGCCTGGC
CCAGCGTCACCGAGATGCGCAAGCTCTTCGGCGGTCCTGGCTCCAGGAGGCCCAGCGCCGACTCTGAATCCCCAGGAACGCCCAGCCCCG
ACGGTGCCGCGTGGGAGCCTCCGGCTCGGGAGTCGCGGCAGCCACCGACGCCACCCCCTCGGACATGCTTCCCCCTGGCGGGTCTGCGTT
CGGCGCGGCCCCTGACCGGGCCGGAGACCGAAGGGAGGCTGCGCCGGCCGCAGCAGCAACAGGAGCGGGCGCAGCGTCCAGCGGATGGTT
TACATTCTTGGCATATCTTCTCCCAACCGCAGGCCGGGGCCCGGGCCTCCTGCTCCTCCTCCTCCATCGCCGCCTCCTATCCTGTCAGCC
GCAGTCGTGCTGCCAGCTCCAGCGAGGAGGAAGAGGAGGGCCCGCCGCAGCTGCCTGGAGCCCAGAGTCCGGCCTACCACGGCGGCCACT
CCTCGGGCAGTGACGACGACCGAGACGGTGAGGGCGGCCACCGCTGGGGAGGGAGGCCCGGGCTCAGGCCTGGAAGCTCCCTATTGGATC
AGGACTGCAGGCCTGACAGTGATGGGTTAAATCTAAGCAGCATGAACTCAGCAGGGGTTTCTGGGAGCCCTGAGCCCCCAACATCTCCAA
GAGCCCCTAGAGAAGAAGGACTCCGGGAGTGGGGTAGTGGCTCTCCGCCCTGCGTCCCAGGTCCCCAGGAGGGACTTCGGCCTATGTCTG
ACTCTGTGGGAGGAGCTTTCCGTGTGGCCAAGGTGAGCTTTCCCTCGTACCTGGCCAGCCCCGCAGGCTCCCGCGGTAGCAGCCGTTATT
CCAGCACGGAGACCCTCAAGGACGACGACCTATGGTCTAGTAGGGGTTCTGGGGGCTGGGGCGTGTACCGCTCCCCTAGCTTTGGAGCTG
GGGAAGGGCTCCTGCGGTCCCAGGCTCGAACCCGTGCCAAAGGACCTGGAGGCACCTCTAGGGCATTGAGGGATGGAGGATTTGAGCCTG
AAAAGAGTCGACAGCGGAAGTCCCTGTCAAATCCAGATATCGCCTCAGAGACCCTGACGCTTCTCAGTTTCCTGCGCTCAGACCTTTCAG
AGCTGAGGGTCCGAAAACCTGGTGGGAGCTCCGGGGACCGTGGAAGCAACCCCCTAGATGGCAGAGACTCACCATCCGCAGGTGGCCCTG
TGGGGCAACTTGAACCCATACCCATCCCAGCCCCAGCATCACCTGGCACGCGCCCCACACTCAAGGACTTGACAGCCACTCTGCGGAGAG
CAAAGTCATTCACCTGCTCTGAGAAGCCCATGGCCCGCCGCCTGCCCCGCACCAGTGCTCTGAAGTCCAGCTCCTCCGAGCTCCTGCTCA
CAGGCCCTGGTGCCGAGGAGGATCCGCTGCCCCTCATCGTCCAGGACCAATATGTGCAGGAGGCCCGCCAGGTTTTTGAGAAGATCCAGC
GCATGGGTGCCCAACAAGATGATGGAAGCGATGCCCCCCCTGGAAGCCCTGACTGGGCAGGGGATGTGACCCGAGGGCAGCGGTCCCAGG
AGGAGCTCTCAGGCCCTGAGTCCAGTCTGACAGATGAAGGCATTGGGGCAGACCCTGAGCCTCCTGTTGCAGCATTTTGCGGCCTGGGTA
CCACAGGGATGTGGCGACCTCTTTCCTCATCCTCGGCCCAGACGAACCACCATGGCCCTGGGACTGAGGACAGTCTGGGCGGGTGGGCCC
TGGTGTCGCCTGAGACCCCTCCCACACCAGGTGCCCTCCGCCGACGACGCAAAGTCCCACCTTCAGGTTCTGGTGGGAGCGAATTGAGCA
ATGGGGAGGCAGGGGAGGCCTACAGGTCCCTGAGTGACCCAATTCCTCAGCGCCACCGGGCTGCCACCTCTGAAGAGCCTACTGGGTTCT
CTGTGGACAGCAACCTCCTGGGCTCACTGAGCCCCAAGACAGGGCTCCCTGCCACCTCAGCCATGGATGAGGGCTTGACCAGTGGTCACA
GTGACTGGTCTGTGGGCAGTGAAGAGAGCAAGGGATATCAGGAGGTTATTCAGAGCATAGTTCAGGGGCCTGGCACCCTGGGGCGTGTGG
TGGACGACAGGATTGCTGGCAAAGCCCCCAAGAAGAAATCCCTGAGTGACCCCAGCCGCCGTGGGGAGCTGGCTGGGCCTGGATTCGAGG
GCCCTGGAGGGGAGCCCATCCGAGAAGTTGAGCCCATGCTGCCTCCATCCAGCAGCGAGCCCATCCTTGTAGAGCAGCGGGCAGAGCCAG
AAGAACCTGGTGCCACCAGGAGCCGGGCACAGTCTGAAAGGGCCCTACCTGAGGCTCTGCCTCCCCCTGCCACTGCCCACCGAAACTTTC
ACCTTGACCCCAAGCTGGCTGACATTCTGTCCCCGAGGCTAATCCGCCGAGGCTCCAAGAAGCGCCCAGCTCGGAGTAGTCACCAGGAGC
TTCGGAGAGACGAGGGCAGTCAGGACCAGACTGGCAGCCTGTCTCGGGCCCGGCCCTCCTCCAGACACGTTCGCCATGCCAGTGTGCCCG
CCACATTTATGCCTATTGTGGTGCCTGAGCCACCAACTTCTGTTGGTCCCCCTGTGGCTGTGCCAGAACCCATAGGCTTCCCTACCCGAG
CCCATCCCACGTTGCAGGCACCATCGCTCGAGGACGTCACCAAGCAGTACATGCTGAACCTGCACTCCGGTGAGGTCCCTGCCCCAGTGC
CAGTGGACATGCCCTGCTTGCCTCTGGCTGCACCGCCCTCTGCTGAGGCCAAGCCCCCTGAGGCAGCTCGGCCTGCAGATGAGCCTACCC
CTGCCAGCAAGTGCTGCAGCAAGCCACAGGTGTACCAAGAGAAGCAGCGGAAGCGTGAGGCTGAGGAGCGGCGCCGCTTCCCCCTGGAGC
AGCGACTAAAGGAGCACATCATTGGCCAGGAGAGCGCCATCGCCACAGTGGGTGCTGCGATCCGGAGGAAGGAGAATGGCTGGTACGATG
AAGAACACCCTCTGGTCTTCCTCTTCTTGGGATCATCTGGAATAGGAAAAACAGAGCTGGCCAAGCAGACAGCCAAATATATGCACAAAG
ATGCTAAAAAGGGCTTCATCAGGCTGGACATGTCCGAGTTCCAGGAGCGACACGAGGTGGCCAAGTTTATTGGGTCTCCACCAGGCTACG
TTGGCCATGAGGAGGGTGGCCAGCTGACCAAGAAGTTGAAGCAGTGCCCCAATGCTGTGGTGCTCTTTGATGAAGTAGACAAGGCCCATC
CAGATGTGCTCACCATCATGCTGCAGCTGTTTGATGAGGGCCGGCTGACAGATGGAAAAGGGAAGACCATTGATTGCAAGGACGCCATCT
TCATCATGACCTCCAATGTGGCCAGCGACGAGATCGCACAGCACGCGCTGCAGCTGAGGCAGGAAGCTTTGGAGATGAGCCGTAACCGTA
TTGCCGAAAACCTGGGGGATGTCCAGATAAGTGACAAGATCACCATCTCAAAGAACTTCAAGGAGAATGTGATTCGCCCTATCCTGAAAG
CTCACTTCCGGAGGGATGAGTTTCTGGGACGGATCAATGAGATCGTCTACTTCCTCCCCTTCTGCCACTCGGAGCTCATCCAACTCGTCA
ACAAGGAACTAAACTTCTGGGCCAAGAGAGCCAAGCAAAGGCACAACATCACGCTGCTCTGGGACCGCGAGGTGGCAGATGTGCTGGTCG
ACGGCTACAATGTGCACTATGGCGCCCGCTCCATCAAACATGAGGTAGAACGCCGTGTGGTGAACCAGCTGGCAGCAGCCTATGAGCAGG
ACCTGCTGCCAGGGGGCTGTACTTTGCGCATCACGGTGGAGGACTCAGACAAGCAGCTACTCAAAAGCCCAGAACTGCCCTCACCCCAGG
CTGAGAAGCGCCTCCCCAAGCTGCGTCTGGAGATCATCGACAAGGACAGCAAGACTCGCAGACTGGACATCCGGGCACCACTGCACCCTG
AGAAGGTGTGCAACACCATCTAGCAGCCACCTGCCTGCTCCTATGTGCCCTCACCATCCAATAAAGGCCCCTTGGCTGTGGCATGGCAAC
TGACTTACCTTCCCCTCATGCCGCTCCCATCTCTACCCAGTCTCAGGCCTGCTTACCTCCTCACAGCCCATGAAGACCCCTTCTCAGCCC
CAAAACCTGAAGGAGGAATTTCGCCCTACTCTGGCCCCTTTGTTGTGGGCCCATAACCTGCTAACAAGCCTTCAGGAGAGGAGCTGCCTT
TCCACCCCCTTCAAGGCAAGGAGGGATGGAGGTCCCTTATTTCCTTCAGAATGATCCCCATCCCCCATAGTCGCCAGACTTTCTCATGTT
CCCAGGAAGCTCAGAAGTATGGCAGCTAAGAACACAGCTGGCTGGAAGAAGACAGGGACCAGACTGAACTGCCACCCTCTGCTAGTCCTC
ATGCAACTCAGTCCCCAGAATGGCTCCACTGGGAGTGGAGGAAGAGCTCAGAGGCCCAGGTGCAGATAGTTCTGCAATTTAGTCTGTAGC
CTCCTCGTTCCCTACCCTAAAATTCTAAGGGGAAGGGACCCATAGAGGCTTGCCTGTTTCCGCTACTATATTATGCCCAGTGTTCCTCCT
CACCCCACGTCCTGGGGTCAGGCCAGACCATGTTTCGTCAGCCTTGGGGACTAGGCCAGTGTTGGGCACCTCCAGGAGGAGGCCTGACTG
GTTCATTACCCTCCCCTACTCAGACTGAGCAGCAGTCCCAGATAACCAAGCAAGCTCAGCTCTGTGGGGGCCTCCTTCAAAAGACCAACA
TCGCAGACATTAGGAAGCTGTAGGAAGAGAGATCATGGGTTTGACCTCTGCCCACATGGCCATGGAGTCAGCCTCAGCCCTGTCTGTACT

>6226_6226_4_ARHGEF17-CLPB_ARHGEF17_chr11_73022875_ENST00000263674_CLPB_chr11_72028264_ENST00000538039_length(amino acids)=1497AA_BP=1111
MLRSLRPLPTLPCAAFGVGRCAPREWGRRGGWPRLPEASPPGVSYATMADGAPRPQLYRSVSFKLLERWSGGPGLREEDTDTPGLRRRAS
CRPTTAARGQPSRRVSKLASGPLAAPAQPRPLRSLSPSVRQLSRRFDAPRLDDGSAGTRDGGVLPAAAEEAAEGPARGAWPSVTEMRKLF
GGPGSRRPSADSESPGTPSPDGAAWEPPARESRQPPTPPPRTCFPLAGLRSARPLTGPETEGRLRRPQQQQERAQRPADGLHSWHIFSQP
QAGARASCSSSSIAASYPVSRSRAASSSEEEEEGPPQLPGAQSPAYHGGHSSGSDDDRDGEGGHRWGGRPGLRPGSSLLDQDCRPDSDGL
NLSSMNSAGVSGSPEPPTSPRAPREEGLREWGSGSPPCVPGPQEGLRPMSDSVGGAFRVAKVSFPSYLASPAGSRGSSRYSSTETLKDDD
LWSSRGSGGWGVYRSPSFGAGEGLLRSQARTRAKGPGGTSRALRDGGFEPEKSRQRKSLSNPDIASETLTLLSFLRSDLSELRVRKPGGS
SGDRGSNPLDGRDSPSAGGPVGQLEPIPIPAPASPGTRPTLKDLTATLRRAKSFTCSEKPMARRLPRTSALKSSSSELLLTGPGAEEDPL
PLIVQDQYVQEARQVFEKIQRMGAQQDDGSDAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSS
SSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGSELSNGEAGEAYRSLSDPIPQRHRAATSEEPTGFSVDSNLLGSL
SPKTGLPATSAMDEGLTSGHSDWSVGSEESKGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIREV
EPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNFHLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQ
TGSLSRARPSSRHVRHASVPATFMPIVVPEPPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLA
APPSAEAKPPEAARPADEPTPASKCCSKPQVYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFL
GSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQL
FDEGRLTDGKGKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKENVIRPILKAHFRRDEFLG
RINEIVYFLPFCHSELIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLR

--------------------------------------------------------------
>6226_6226_5_ARHGEF17-CLPB_ARHGEF17_chr11_73022875_ENST00000263674_CLPB_chr11_72028264_ENST00000543042_length(transcript)=4761nt_BP=3542nt
GAGCGAGCAGCCAAGGGCGTTGGGCAGGCGGACGCAGAGTCGAGGAACCAAGCGCTGGGATCCCGCCCAGGCGGTGCCGCGGTGCCCCTG
GTCGCTCCAGCCGCGGCGGGGGCTGGGCCTGGGGGTCGGCGCTGAGGCGGGAGGGGCCGCCCGGGATGGAGACGTTGCGGCCGGTGGCCA
CAGAAACTTGAGCCGCGGCAGAGAAACCTCTGCTCCGGTCTCTGCGTCCTCTTCCCACACTCCCGTGCGCTGCTTTCGGCGTGGGCCGCT
GCGCTCCTAGGGAGTGGGGGCGCAGGGGGGGTTGGCCGCGGCTGCCCGAGGCCAGCCCCCCCGGAGTGAGTTACGCCACTATGGCGGACG
GGGCACCCCGGCCCCAGCTTTACCGCAGCGTCTCGTTCAAGCTGCTGGAGCGCTGGAGCGGCGGCCCCGGGCTGAGGGAGGAGGACACGG
ACACCCCCGGCTTGAGGCGACGCGCCTCGTGCCGGCCGACCACGGCTGCCCGGGGCCAGCCCTCTCGGCGCGTGTCCAAGCTGGCGTCTG
GGCCCCTGGCCGCCCCCGCGCAGCCGCGCCCGCTCCGCAGCCTCTCGCCGTCGGTTCGCCAGCTCTCCCGGCGCTTCGACGCGCCGCGTC
TGGACGACGGCTCCGCTGGGACCCGAGACGGAGGCGTCTTACCCGCGGCCGCGGAAGAAGCGGCCGAGGGCCCAGCGCGAGGAGCCTGGC
CCAGCGTCACCGAGATGCGCAAGCTCTTCGGCGGTCCTGGCTCCAGGAGGCCCAGCGCCGACTCTGAATCCCCAGGAACGCCCAGCCCCG
ACGGTGCCGCGTGGGAGCCTCCGGCTCGGGAGTCGCGGCAGCCACCGACGCCACCCCCTCGGACATGCTTCCCCCTGGCGGGTCTGCGTT
CGGCGCGGCCCCTGACCGGGCCGGAGACCGAAGGGAGGCTGCGCCGGCCGCAGCAGCAACAGGAGCGGGCGCAGCGTCCAGCGGATGGTT
TACATTCTTGGCATATCTTCTCCCAACCGCAGGCCGGGGCCCGGGCCTCCTGCTCCTCCTCCTCCATCGCCGCCTCCTATCCTGTCAGCC
GCAGTCGTGCTGCCAGCTCCAGCGAGGAGGAAGAGGAGGGCCCGCCGCAGCTGCCTGGAGCCCAGAGTCCGGCCTACCACGGCGGCCACT
CCTCGGGCAGTGACGACGACCGAGACGGTGAGGGCGGCCACCGCTGGGGAGGGAGGCCCGGGCTCAGGCCTGGAAGCTCCCTATTGGATC
AGGACTGCAGGCCTGACAGTGATGGGTTAAATCTAAGCAGCATGAACTCAGCAGGGGTTTCTGGGAGCCCTGAGCCCCCAACATCTCCAA
GAGCCCCTAGAGAAGAAGGACTCCGGGAGTGGGGTAGTGGCTCTCCGCCCTGCGTCCCAGGTCCCCAGGAGGGACTTCGGCCTATGTCTG
ACTCTGTGGGAGGAGCTTTCCGTGTGGCCAAGGTGAGCTTTCCCTCGTACCTGGCCAGCCCCGCAGGCTCCCGCGGTAGCAGCCGTTATT
CCAGCACGGAGACCCTCAAGGACGACGACCTATGGTCTAGTAGGGGTTCTGGGGGCTGGGGCGTGTACCGCTCCCCTAGCTTTGGAGCTG
GGGAAGGGCTCCTGCGGTCCCAGGCTCGAACCCGTGCCAAAGGACCTGGAGGCACCTCTAGGGCATTGAGGGATGGAGGATTTGAGCCTG
AAAAGAGTCGACAGCGGAAGTCCCTGTCAAATCCAGATATCGCCTCAGAGACCCTGACGCTTCTCAGTTTCCTGCGCTCAGACCTTTCAG
AGCTGAGGGTCCGAAAACCTGGTGGGAGCTCCGGGGACCGTGGAAGCAACCCCCTAGATGGCAGAGACTCACCATCCGCAGGTGGCCCTG
TGGGGCAACTTGAACCCATACCCATCCCAGCCCCAGCATCACCTGGCACGCGCCCCACACTCAAGGACTTGACAGCCACTCTGCGGAGAG
CAAAGTCATTCACCTGCTCTGAGAAGCCCATGGCCCGCCGCCTGCCCCGCACCAGTGCTCTGAAGTCCAGCTCCTCCGAGCTCCTGCTCA
CAGGCCCTGGTGCCGAGGAGGATCCGCTGCCCCTCATCGTCCAGGACCAATATGTGCAGGAGGCCCGCCAGGTTTTTGAGAAGATCCAGC
GCATGGGTGCCCAACAAGATGATGGAAGCGATGCCCCCCCTGGAAGCCCTGACTGGGCAGGGGATGTGACCCGAGGGCAGCGGTCCCAGG
AGGAGCTCTCAGGCCCTGAGTCCAGTCTGACAGATGAAGGCATTGGGGCAGACCCTGAGCCTCCTGTTGCAGCATTTTGCGGCCTGGGTA
CCACAGGGATGTGGCGACCTCTTTCCTCATCCTCGGCCCAGACGAACCACCATGGCCCTGGGACTGAGGACAGTCTGGGCGGGTGGGCCC
TGGTGTCGCCTGAGACCCCTCCCACACCAGGTGCCCTCCGCCGACGACGCAAAGTCCCACCTTCAGGTTCTGGTGGGAGCGAATTGAGCA
ATGGGGAGGCAGGGGAGGCCTACAGGTCCCTGAGTGACCCAATTCCTCAGCGCCACCGGGCTGCCACCTCTGAAGAGCCTACTGGGTTCT
CTGTGGACAGCAACCTCCTGGGCTCACTGAGCCCCAAGACAGGGCTCCCTGCCACCTCAGCCATGGATGAGGGCTTGACCAGTGGTCACA
GTGACTGGTCTGTGGGCAGTGAAGAGAGCAAGGGATATCAGGAGGTTATTCAGAGCATAGTTCAGGGGCCTGGCACCCTGGGGCGTGTGG
TGGACGACAGGATTGCTGGCAAAGCCCCCAAGAAGAAATCCCTGAGTGACCCCAGCCGCCGTGGGGAGCTGGCTGGGCCTGGATTCGAGG
GCCCTGGAGGGGAGCCCATCCGAGAAGTTGAGCCCATGCTGCCTCCATCCAGCAGCGAGCCCATCCTTGTAGAGCAGCGGGCAGAGCCAG
AAGAACCTGGTGCCACCAGGAGCCGGGCACAGTCTGAAAGGGCCCTACCTGAGGCTCTGCCTCCCCCTGCCACTGCCCACCGAAACTTTC
ACCTTGACCCCAAGCTGGCTGACATTCTGTCCCCGAGGCTAATCCGCCGAGGCTCCAAGAAGCGCCCAGCTCGGAGTAGTCACCAGGAGC
TTCGGAGAGACGAGGGCAGTCAGGACCAGACTGGCAGCCTGTCTCGGGCCCGGCCCTCCTCCAGACACGTTCGCCATGCCAGTGTGCCCG
CCACATTTATGCCTATTGTGGTGCCTGAGCCACCAACTTCTGTTGGTCCCCCTGTGGCTGTGCCAGAACCCATAGGCTTCCCTACCCGAG
CCCATCCCACGTTGCAGGCACCATCGCTCGAGGACGTCACCAAGCAGTACATGCTGAACCTGCACTCCGGTGAGGTCCCTGCCCCAGTGC
CAGTGGACATGCCCTGCTTGCCTCTGGCTGCACCGCCCTCTGCTGAGGCCAAGCCCCCTGAGGCAGCTCGGCCTGCAGATGAGCCTACCC
CTGCCAGCAAGTGCTGCAGCAAGCCACAGGTGTACCAAGAGAAGCAGCGGAAGCGTGAGGCTGAGGAGCGGCGCCGCTTCCCCCTGGAGC
AGCGACTAAAGGAGCACATCATTGGCCAGGAGAGCGCCATCGCCACAGTGGGTGCTGCGATCCGGAGGAAGGAGAATGGCTGGTACGATG
AAGAACACCCTCTGGTCTTCCTCTTCTTGGGATCATCTGGAATAGGAAAAACAGAGCTGGCCAAGCAGACAGCCAAATATATGCACAAAG
ATGCTAAAAAGGGCTTCATCAGGCTGGACATGTCCGAGTTCCAGGAGCGACACGAGGTGGCCAAGTTTATTGGGTCTCCACCAGGCTACG
TTGGCCATGAGGAGGGTGGCCAGCTGACCAAGAAGTTGAAGCAGTGCCCCAATGCTGTGGTGCTCTTTGATGAAGTAGACAAGGCCCATC
CAGATGTGCTCACCATCATGCTGCAGCTGTTTGATGAGGGCCGGCTGACAGATGGAAAAGGGAAGACCATTGATTGCAAGGACGCCATCT
TCATCATGACCTCCAATGTGGCCAGCGACGAGATCGCACAGCACGCGCTGCAGCTGAGGCAGGAAGCTTTGGAGATGAGCCGTAACCGTA
TTGCCGAAAACCTGGGGGATGTCCAGATAAGTGACAAGATCACCATCTCAAAGAACTTCAAGGAGAATGTGATTCGCCCTATCCTGAAAG
CTCACTTCCGGAGGGATGAGTTTCTGGGACGGATCAATGAGATCGTCTACTTCCTCCCCTTCTGCCACTCGGAGCTCATCCAACTCGTCA
ACAAGGAACTAAACTTCTGGGCCAAGAGAGCCAAGCAAAGGCACAACATCACGCTGCTCTGGGACCGCGAGGTGGCAGATGTGCTGGTCG
ACGGCTACAATGTGCACTATGGCGCCCGCTCCATCAAACATGAGGTAGAACGCCGTGTGGTGAACCAGCTGGCAGCAGCCTATGAGCAGG
ACCTGCTGCCAGGGGGCTGTACTTTGCGCATCACGGTGGAGGACTCAGACAAGCAGCTACTCAAAAGCCCAGAACTGCCCTCACCCCAGG
CTGAGAAGCGCCTCCCCAAGCTGCGTCTGGAGATCATCGACAAGGACAGCAAGACTCGCAGACTGGACATCCGGGCACCACTGCACCCTG

>6226_6226_5_ARHGEF17-CLPB_ARHGEF17_chr11_73022875_ENST00000263674_CLPB_chr11_72028264_ENST00000543042_length(amino acids)=1497AA_BP=1111
MLRSLRPLPTLPCAAFGVGRCAPREWGRRGGWPRLPEASPPGVSYATMADGAPRPQLYRSVSFKLLERWSGGPGLREEDTDTPGLRRRAS
CRPTTAARGQPSRRVSKLASGPLAAPAQPRPLRSLSPSVRQLSRRFDAPRLDDGSAGTRDGGVLPAAAEEAAEGPARGAWPSVTEMRKLF
GGPGSRRPSADSESPGTPSPDGAAWEPPARESRQPPTPPPRTCFPLAGLRSARPLTGPETEGRLRRPQQQQERAQRPADGLHSWHIFSQP
QAGARASCSSSSIAASYPVSRSRAASSSEEEEEGPPQLPGAQSPAYHGGHSSGSDDDRDGEGGHRWGGRPGLRPGSSLLDQDCRPDSDGL
NLSSMNSAGVSGSPEPPTSPRAPREEGLREWGSGSPPCVPGPQEGLRPMSDSVGGAFRVAKVSFPSYLASPAGSRGSSRYSSTETLKDDD
LWSSRGSGGWGVYRSPSFGAGEGLLRSQARTRAKGPGGTSRALRDGGFEPEKSRQRKSLSNPDIASETLTLLSFLRSDLSELRVRKPGGS
SGDRGSNPLDGRDSPSAGGPVGQLEPIPIPAPASPGTRPTLKDLTATLRRAKSFTCSEKPMARRLPRTSALKSSSSELLLTGPGAEEDPL
PLIVQDQYVQEARQVFEKIQRMGAQQDDGSDAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSS
SSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGSELSNGEAGEAYRSLSDPIPQRHRAATSEEPTGFSVDSNLLGSL
SPKTGLPATSAMDEGLTSGHSDWSVGSEESKGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIREV
EPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNFHLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQ
TGSLSRARPSSRHVRHASVPATFMPIVVPEPPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLA
APPSAEAKPPEAARPADEPTPASKCCSKPQVYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFL
GSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQL
FDEGRLTDGKGKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKENVIRPILKAHFRRDEFLG
RINEIVYFLPFCHSELIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARHGEF17-CLPB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGEF17-CLPB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGEF17-CLPB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC42253933-methylglutaconic aciduria type 73CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0014548Epilepsy, Generalized1GENOMICS_ENGLAND
TgeneC0036572Seizures1GENOMICS_ENGLAND