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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CEP350-TDRD5 (FusionGDB2 ID:HG9857TG163589)

Fusion Gene Summary for CEP350-TDRD5

check button Fusion gene summary
Fusion gene informationFusion gene name: CEP350-TDRD5
Fusion gene ID: hg9857tg163589
HgeneTgene
Gene symbol

CEP350

TDRD5

Gene ID

9857

163589

Gene namecentrosomal protein 350tudor domain containing 5
SynonymsCAP350|GM133TUDOR3
Cytomap('CEP350')('TDRD5')

1q25.2

1q25.2

Type of geneprotein-codingprotein-coding
Descriptioncentrosome-associated protein 350centrosomal protein 350kDatudor domain-containing protein 5testicular tissue protein Li 194
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000367607, ENST00000490141, 
Fusion gene scores* DoF score11 X 10 X 8=8802 X 3 X 2=12
# samples 133
** MAII scorelog2(13/880*10)=-2.75899190049621
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CEP350 [Title/Abstract] AND TDRD5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCEP350(180010383)-TDRD5(179659831), # samples:3
Anticipated loss of major functional domain due to fusion event.CEP350-TDRD5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CEP350-TDRD5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CEP350-TDRD5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CEP350-TDRD5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CEP350-TDRD5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CEP350-TDRD5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CEP350 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TDRD5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-0799-01ACEP350chr1

180010383

-TDRD5chr1

179659831

+
ChimerDB4OVTCGA-13-0799-01ACEP350chr1

180010383

+TDRD5chr1

179659831

+
ChimerDB4OVTCGA-13-0799CEP350chr1

180010383

+TDRD5chr1

179659830

+


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Fusion Gene ORF analysis for CEP350-TDRD5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000367607ENST00000294848CEP350chr1

180010383

+TDRD5chr1

179659831

+
Frame-shiftENST00000367607ENST00000294848CEP350chr1

180010383

+TDRD5chr1

179659830

+
Frame-shiftENST00000367607ENST00000444136CEP350chr1

180010383

+TDRD5chr1

179659831

+
Frame-shiftENST00000367607ENST00000444136CEP350chr1

180010383

+TDRD5chr1

179659830

+
In-frameENST00000367607ENST00000367614CEP350chr1

180010383

+TDRD5chr1

179659831

+
In-frameENST00000367607ENST00000367614CEP350chr1

180010383

+TDRD5chr1

179659830

+
intron-3CDSENST00000490141ENST00000294848CEP350chr1

180010383

+TDRD5chr1

179659831

+
intron-3CDSENST00000490141ENST00000294848CEP350chr1

180010383

+TDRD5chr1

179659830

+
intron-3CDSENST00000490141ENST00000367614CEP350chr1

180010383

+TDRD5chr1

179659831

+
intron-3CDSENST00000490141ENST00000367614CEP350chr1

180010383

+TDRD5chr1

179659830

+
intron-3CDSENST00000490141ENST00000444136CEP350chr1

180010383

+TDRD5chr1

179659831

+
intron-3CDSENST00000490141ENST00000444136CEP350chr1

180010383

+TDRD5chr1

179659830

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000367607CEP350chr1180010383+ENST00000367614TDRD5chr1179659831+5214463941846621414
ENST00000367607CEP350chr1180010383+ENST00000367614TDRD5chr1179659830+5214463941846621414

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367607ENST00000367614CEP350chr1180010383+TDRD5chr1179659831+0.0009782960.99902165
ENST00000367607ENST00000367614CEP350chr1180010383+TDRD5chr1179659830+0.0009782960.99902165

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Fusion Genomic Features for CEP350-TDRD5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CEP350chr1180010383+TDRD5chr1179659830+0.811825930.18817407
CEP350chr1180010383+TDRD5chr1179659830+0.811825930.18817407
CEP350chr1180010383+TDRD5chr1179659830+0.811825930.18817407
CEP350chr1180010383+TDRD5chr1179659830+0.811825930.18817407

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CEP350-TDRD5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:180010383/chr1:179659831)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCEP350chr1:180010383chr1:179659830ENST00000367607+1838598_64514073118.0Coiled coilOntology_term=ECO:0000255
HgeneCEP350chr1:180010383chr1:179659831ENST00000367607+1838598_64514073118.0Coiled coilOntology_term=ECO:0000255
HgeneCEP350chr1:180010383chr1:179659830ENST00000367607+18381112_128114073118.0Compositional biasNote=Ser-rich
HgeneCEP350chr1:180010383chr1:179659831ENST00000367607+18381112_128114073118.0Compositional biasNote=Ser-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCEP350chr1:180010383chr1:179659830ENST00000367607+18381369_141114073118.0Coiled coilOntology_term=ECO:0000255
HgeneCEP350chr1:180010383chr1:179659830ENST00000367607+18381707_180014073118.0Coiled coilOntology_term=ECO:0000255
HgeneCEP350chr1:180010383chr1:179659830ENST00000367607+18381856_189914073118.0Coiled coilOntology_term=ECO:0000255
HgeneCEP350chr1:180010383chr1:179659830ENST00000367607+18382051_211014073118.0Coiled coilOntology_term=ECO:0000255
HgeneCEP350chr1:180010383chr1:179659830ENST00000367607+18382719_275214073118.0Coiled coilOntology_term=ECO:0000255
HgeneCEP350chr1:180010383chr1:179659831ENST00000367607+18381369_141114073118.0Coiled coilOntology_term=ECO:0000255
HgeneCEP350chr1:180010383chr1:179659831ENST00000367607+18381707_180014073118.0Coiled coilOntology_term=ECO:0000255
HgeneCEP350chr1:180010383chr1:179659831ENST00000367607+18381856_189914073118.0Coiled coilOntology_term=ECO:0000255
HgeneCEP350chr1:180010383chr1:179659831ENST00000367607+18382051_211014073118.0Coiled coilOntology_term=ECO:0000255
HgeneCEP350chr1:180010383chr1:179659831ENST00000367607+18382719_275214073118.0Coiled coilOntology_term=ECO:0000255
HgeneCEP350chr1:180010383chr1:179659830ENST00000367607+18381502_155614073118.0Compositional biasNote=Ser-rich
HgeneCEP350chr1:180010383chr1:179659831ENST00000367607+18381502_155614073118.0Compositional biasNote=Ser-rich
HgeneCEP350chr1:180010383chr1:179659830ENST00000367607+18382517_255914073118.0DomainCAP-Gly
HgeneCEP350chr1:180010383chr1:179659831ENST00000367607+18382517_255914073118.0DomainCAP-Gly
TgeneTDRD5chr1:180010383chr1:179659830ENST000002948481517127_202899982.0DomainHTH OST-type 2
TgeneTDRD5chr1:180010383chr1:179659830ENST000002948481517295_369899982.0DomainHTH OST-type 3
TgeneTDRD5chr1:180010383chr1:179659830ENST000002948481517525_584899982.0DomainTudor
TgeneTDRD5chr1:180010383chr1:179659830ENST0000029484815177_80899982.0DomainHTH OST-type 1
TgeneTDRD5chr1:180010383chr1:179659830ENST000003676141517127_202899982.0DomainHTH OST-type 2
TgeneTDRD5chr1:180010383chr1:179659830ENST000003676141517295_369899982.0DomainHTH OST-type 3
TgeneTDRD5chr1:180010383chr1:179659830ENST000003676141517525_584899982.0DomainTudor
TgeneTDRD5chr1:180010383chr1:179659830ENST0000036761415177_80899982.0DomainHTH OST-type 1
TgeneTDRD5chr1:180010383chr1:179659830ENST000004441361618127_2029531036.0DomainHTH OST-type 2
TgeneTDRD5chr1:180010383chr1:179659830ENST000004441361618295_3699531036.0DomainHTH OST-type 3
TgeneTDRD5chr1:180010383chr1:179659830ENST000004441361618525_5849531036.0DomainTudor
TgeneTDRD5chr1:180010383chr1:179659830ENST0000044413616187_809531036.0DomainHTH OST-type 1
TgeneTDRD5chr1:180010383chr1:179659831ENST000002948481517127_202899982.0DomainHTH OST-type 2
TgeneTDRD5chr1:180010383chr1:179659831ENST000002948481517295_369899982.0DomainHTH OST-type 3
TgeneTDRD5chr1:180010383chr1:179659831ENST000002948481517525_584899982.0DomainTudor
TgeneTDRD5chr1:180010383chr1:179659831ENST0000029484815177_80899982.0DomainHTH OST-type 1
TgeneTDRD5chr1:180010383chr1:179659831ENST000003676141517127_202899982.0DomainHTH OST-type 2
TgeneTDRD5chr1:180010383chr1:179659831ENST000003676141517295_369899982.0DomainHTH OST-type 3
TgeneTDRD5chr1:180010383chr1:179659831ENST000003676141517525_584899982.0DomainTudor
TgeneTDRD5chr1:180010383chr1:179659831ENST0000036761415177_80899982.0DomainHTH OST-type 1
TgeneTDRD5chr1:180010383chr1:179659831ENST000004441361618127_2029531036.0DomainHTH OST-type 2
TgeneTDRD5chr1:180010383chr1:179659831ENST000004441361618295_3699531036.0DomainHTH OST-type 3
TgeneTDRD5chr1:180010383chr1:179659831ENST000004441361618525_5849531036.0DomainTudor
TgeneTDRD5chr1:180010383chr1:179659831ENST0000044413616187_809531036.0DomainHTH OST-type 1


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Fusion Gene Sequence for CEP350-TDRD5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15858_15858_1_CEP350-TDRD5_CEP350_chr1_180010383_ENST00000367607_TDRD5_chr1_179659830_ENST00000367614_length(transcript)=5214nt_BP=4639nt
GCCCGACTGCTCCCGCCCTGCCTCGCGCCGCCGCCACAGCCGCTGCCGCTGGCGCCGCTCCTCCTCCGTGTCAGTTGTTGGGCTGTAATG
GCGACTGGGCCGCCCCTGACGAAGTGACTCCCGGGCCGGGGAGCGGGGCCAGACCTGCGCCAGAGAGAACTGCAGGGAGCCGCAGCTCGG
GGGGTGGCTTGCCCTGAGGGAGGGGAGGCAGCCTTTCCGCCTTGTCTTCCTTCCCAGCGGACCGGCGGATCCCCGGAGCCGGTGCGAGGA
GGGCACCCGGTGCGTCCCCGGAGCGGGGAGGCCAGGCCGGGCAGCCCTGGGGCCGGTCGGGGCGGCGTCACTGCACCCTCCGCCAGGCTC
CGCGGGATGCACCGTGGTAGCCGAGGGCGGAGGCGACACTCTCAGGTAAATTGGCAGGATGAGGAGCAGCAAATCAAAAGAGGTGCCTTT
ACCAAATCCAAGGAACTCTCAAAGCAAGGATACTGTTCAAGCAGATATAACCACATCGTGGGATGCACTTTCTCAAACCAAGGCTGCTCT
GAGACACATTGAAAATAAATTAGAAGTAGCCCCTACAAGTACAGCTGTGTGTGATTCTGTCATGGATACCAAGAAGTCTTCTACAAGTGC
TACTCGAAAAATAAGTAGAAAAGATGGTAGATACCTGGATGATTCTTGGGTTAATGCTCCAATCTCCAAATCCACTAAATCACGAAAAGA
GAAATCTCGTAGTCCTCTCAGGGCCACCACCCTGGAGAGTAATGTGAAGAAAAATAATCGTGTGGAATTTCGTGAACCTTTGGTTTCTTA
TAGGGAAATCCATGGTGCACCTTCCAATTTCAGTTCCAGCCATCTGGAATCAAAGCACGTATACTGTGTAGATGTTAATGAAGAAAAGAC
TGAGAGCGGTAACTGGATGATAGGCAGTCGAGAAGAACGGAATATACGGAGCTGTGATTTTGAGAGCTCCCAATCATCTGTCATCAATGA
TACAGTTGTTAGGTTTTTAAATGATCGACCAGCAATTGATGCATTGCAAAATTCTGAATGTTTGATTAGGATGGGAGCTTCTATGAGAAC
TGAGGAAGAAATGCCTAACAGAACAAAAGGAAGTGAGAATAATTTGAAGCTTTCTGTGAATAACATGGCCCATGATACTGATCCAAAAGC
GTTACGACTAACTGACTCTTCTCCATCCTCTACTAGTACTTCTAATTCCCAAAGATTAGATATTCTAAAGCGGCGACAACATGATGTCAA
ACTGGAAAAACTTAAGGAACGGATTAGAAAACAGTGGGAACACTCAGAAGAAACAAATGGCCGGGGCCAGAAGCTGGGTCATATTGACCA
TCCAGTAATGGTTGTTAATGTTGATAACTCAGTAACAGCAAAAGTCAGAAAAGTGGCAACAGCACCACCTGCTCCAGCATATAAAGGTTT
CAACCCTTCAGAGACCAAGATTCGAACACCTGATGGGAAAGTGTGGCAGGAGGCTGAGTTTCAAAACATGAGTAGAGAACTGTATCGAGA
TTTAGCACTTCACTTTGCAGATGATATTTCTATAAAGGAGAAACCTGCTGAAAAAAGTAAAGAGAAGAAAGTAGTCAAGCCAGTACGAAA
AGTCCAAAAAGTAGCACAGTTATCAAGTACAGAATGCAGAACAGGTAGTAGTCATCTTATAAGTACATCTTCTTGGCGAGATGGACAAAA
ATTAGTAAAGAAGATTCTGGGACCTGCTCCCAGAATGGAGCCAAAAGAGCAAAGAACAGCATCAAGTGACAGAGGTGGAAGAGAAAGAAC
TGCTAAATCTGGGGGTCACATTGGAAGAGCAGAATCTGATCCCAGGTTGGACGTTTTACATAGACATCTTCAAAGAAACTCAGAACGTTC
GAGAAGTAAATCTCGGTCTGAAAATAATATAAAGAAACTAGCTTCATCTCTTCCAGATAATAAGCAGGAGGAAAATACTGCCTTAAATAA
GGACTTTTTACCTATTGAAATTCGTGGCATTCTTGATGACCTACAGCTGGATTCTACAGCTCACACTGCAAAGCAAGATACTGTAGAGTT
ACAGAACCAGAAGTCATCAGCACCAGTACATGCTCCTAGGAGTCACAGCCCAGTAAAAAGAAAACCTGACAAAATAACAGCTAATGAAGA
TCCCCCTGTTATTTCCAAAAGGCGCCACTATGACACAGATGAGGTACGACAGTACATTGTTAGGCAGCAGGAGGAAAGGAAGAGAAAGCA
AAATGAAGAGAAGAAGGCTCAAAAGGAGGCTACAGAACAGAAAAACAAACGATTACAAGAGCTCTACCGGAAGCAGAAGGAAGCCTTTAC
TAAAGTAAAAAATGTCCCTCCTTCTGAGCCATCAGCAACTAGGCGACTACAGGAAACTTACTCCAAATTGCTACTAGAAAAGACCTTGCT
TGAAGAGCCATCTCATCAACATGTTACGCAGGAAACACAGGCCAAACCAGGGTATCAGCCATCTGGAGAATCTGACAAAGAAAACAAAGT
ACAGGAACGTCCCCCAAGTGCATCTTCCAGTAGTGACATGTCTCTCTCAGAACCTCCACAGCCTCTTGCAAGAAAAGACTTGATGGAATC
TACATGGATGCAGCCTGAAAGATTGAGCCCACAAGTTCACCATTCTCAACCACAGCCTTTTGCTGGAACAGCTGGAAGTTTACTCTCCCA
TCTCTTGAGTTTAGAGCATGTAGGAATTTTGCATAAGGATTTTGAATCTATTTTACCAACCAGGAAGAATCATAATATGGCTTCAAGGCC
ATTAACTTTTACACCTCAACCATATGTGACCTCACCAGCTGCTTATACAGATGCCTTGTTAAAACCTAGTGCCAGCCAATATAAGAGTAA
ACTGGATCGTATTGAAGCCTTGAAAGCAACAGCTGCTTCTTTGTCCAGCAGAATTGAAAGTGAAGCCAAGAAATTAGCTGGGGCCAGCAT
TAACTATGGGTCAGCATGGAACACTGAGTATGATGTGCAGCAGGCACCTCAAGAAGATGGACCTTGGACCAAGGCTGTAACTCCACCTGT
GAAAGATGATAATGAAGATGTTTTCTCTGCCAGAATTCAGAAGATGCTGGGAAGCTGTGTATCTCATGCAACTTTTGATGATGATCTTCC
TGGTGTAGGCAATCTTAGTGAATTTAAAAAGCTTCCTGAGATGATAAGACCACAGAGTGCCATATCAAGCTTTAGAGTGAGATCCCCTGG
TCCCAAACCAGAAGGGCTACTGGCACAGTTATGTAAAAGGCAGACTGACTCTTCTAGCTCTGATATGCAAGCCTGTTCTCAAGACAAAGC
CAAAATATCTCTTGGTTCCAGCATAGATTCAGTCAGTGAAGGGCCTCTTCTTAGTGAGGGGAGTCTCTCTGAAGAAGAGGGAGACCAGGA
TGGACAGCCCCTTTTGAAAGTAGCAGAAATTTTAAAAGAAAAGGAATTTTGTCCTGGAGAAAGAAATAGTTATGAACCCATCAAAGAGTT
TCAGAAAGAAGCTGAAAAATTCTTGCCACTTTTTGGGCACATAGGTGGTACACAAAGCAAAGGACCATGGGAAGAATTGGCAAAGGGAAG
TCCACATAGCGTCATTAATATTTTTACAAAATCCTATCAGTTATATGGAAAAGGGTTTGAAGACAAGTTGGACAGAGGAACATCAACATC
ACGGCCTTTGAATGCCACCGCAACTCCTCTAAGTGGTGTTTCATATGAAGATGATTTTGTCTCCTCTCCAGGGACTGGGACTTCGACAGA
AAAAAAATCAACTCTTGAACCTCATAGCACTTTAAGCCCTCAGGAGGACCATTCTAACAGAAAGTCTGCCTATGATCCTTCCTCTGTGGA
TGTTACCTCCCAGCATTCATCAGGAGCCCAGTCTGCTGCATCGTCTCGTTCATCTACTTCTTCTAAAGGAAAGAAAGGAAAAAAGGAAAA
GACAGAATGGTTGGATTCATTCACTGGAAATGTTCAGAACTCACTTCTTGATGAGGAAAAAGCAGAACGTGGCTCCCATCAAGGAAAGAA
ATCTGGGACCAGCAGCAAACTTTCTGTTAAAGATTTTGAGCAGACTCTTGATACAGATAGCACTTTGGAGGATCTTTCTGGACATTCTGT
GAGTGTCTCATCAGATAAGGGAAGATCTCAGAAAACTCCAACTTCTCCCCTGTCACCAAGTTCCCAGAAATCATTGCAGTTTGACGTTGC
AGGAACTTCTTCAGAAAGATCTAAGTCGTCAGTAATGCCTCCAACTATAACAGGATTTAAGCCTAATGCACCTCTCACTGATCTGAACCC
GGCAGCCAGCAGAACAACGACAGAGAACATGGCTCCAATACCAGGTTCTAAGCGCTTTTCTCCTGCTGGCCTCCATCATCGTATGGCAGC
AGAACTCAGTTATCTGAACGCCATTGAGGAGTCGGTGCGCCAACTGTCAGATGTAGAAAGAGTTAGAGGCATTTCACTTGCTCAGCAGGA
GAGTGTGTCTCTAGCTCAGATAATAAAGGCACAACAGCAACGCCATGAAAGAGACTTGGCCCTCTTGAAACTAAAGGCTGAACAAGAGGC
TCTGGAGAGTCAGAGACAATTAGAAGAAACCCGAAACAAAGCAGCTCAGTGGAAAGCTCACCAGAGATCCTAAAGAATGAAGATTTTTCT
AGCAGCCGTGCTATTACATTGTACAAAGACAAGCGTCAAGAATCTGTAGACCAGCTGTCTTTGATTTTGTCTTATGAGTGCCAGATTTCT
CAGAAGCTCTACATTCCTCGAAGTACAGCCACTGCTGCCTTAGGTGCTGCCGCACGGTTAGCTACATCCAGGAGCCTCCTACACTGGTAC
CCCAGTGTGAAAAGGATGGAAGCATGAGGGAGGGAGGGAGGAGGGAGAAAAACAGAATCCAGCCGCTTAGGCTTTGATGAACTCCCAGGC
CAAAATGAGGAGTTATTGAAGCAAAATAGTATCTTGATCATTGATACTTTTGTCTTTCTGTGACTATATGTTAGCTTTATTATGCTAACA
GTCTACTTTGATGTGTAAGTAAGTATTGATATTTACTGTTAATCTTGATTTTTCTTGATTTTATTCTGTGTCATTTTGTTCACCTTTGTT

>15858_15858_1_CEP350-TDRD5_CEP350_chr1_180010383_ENST00000367607_TDRD5_chr1_179659830_ENST00000367614_length(amino acids)=1414AA_BP=
MRSSKSKEVPLPNPRNSQSKDTVQADITTSWDALSQTKAALRHIENKLEVAPTSTAVCDSVMDTKKSSTSATRKISRKDGRYLDDSWVNA
PISKSTKSRKEKSRSPLRATTLESNVKKNNRVEFREPLVSYREIHGAPSNFSSSHLESKHVYCVDVNEEKTESGNWMIGSREERNIRSCD
FESSQSSVINDTVVRFLNDRPAIDALQNSECLIRMGASMRTEEEMPNRTKGSENNLKLSVNNMAHDTDPKALRLTDSSPSSTSTSNSQRL
DILKRRQHDVKLEKLKERIRKQWEHSEETNGRGQKLGHIDHPVMVVNVDNSVTAKVRKVATAPPAPAYKGFNPSETKIRTPDGKVWQEAE
FQNMSRELYRDLALHFADDISIKEKPAEKSKEKKVVKPVRKVQKVAQLSSTECRTGSSHLISTSSWRDGQKLVKKILGPAPRMEPKEQRT
ASSDRGGRERTAKSGGHIGRAESDPRLDVLHRHLQRNSERSRSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDST
AHTAKQDTVELQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRKQNEEKKAQKEATEQKNKRLQ
ELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKLLLEKTLLEEPSHQHVTQETQAKPGYQPSGESDKENKVQERPPSASSSSDMSLSEPP
QPLARKDLMESTWMQPERLSPQVHHSQPQPFAGTAGSLLSHLLSLEHVGILHKDFESILPTRKNHNMASRPLTFTPQPYVTSPAAYTDAL
LKPSASQYKSKLDRIEALKATAASLSSRIESEAKKLAGASINYGSAWNTEYDVQQAPQEDGPWTKAVTPPVKDDNEDVFSARIQKMLGSC
VSHATFDDDLPGVGNLSEFKKLPEMIRPQSAISSFRVRSPGPKPEGLLAQLCKRQTDSSSSDMQACSQDKAKISLGSSIDSVSEGPLLSE
GSLSEEEGDQDGQPLLKVAEILKEKEFCPGERNSYEPIKEFQKEAEKFLPLFGHIGGTQSKGPWEELAKGSPHSVINIFTKSYQLYGKGF
EDKLDRGTSTSRPLNATATPLSGVSYEDDFVSSPGTGTSTEKKSTLEPHSTLSPQEDHSNRKSAYDPSSVDVTSQHSSGAQSAASSRSST
SSKGKKGKKEKTEWLDSFTGNVQNSLLDEEKAERGSHQGKKSGTSSKLSVKDFEQTLDTDSTLEDLSGHSVSVSSDKGRSQKTPTSPLSP
SSQKSLQFDVAGTSSERSKSSVMPPTITGFKPNAPLTDLNPAASRTTTENMAPIPGSKRFSPAGLHHRMAAELSYLNAIEESVRQLSDVE

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>15858_15858_2_CEP350-TDRD5_CEP350_chr1_180010383_ENST00000367607_TDRD5_chr1_179659831_ENST00000367614_length(transcript)=5214nt_BP=4639nt
GCCCGACTGCTCCCGCCCTGCCTCGCGCCGCCGCCACAGCCGCTGCCGCTGGCGCCGCTCCTCCTCCGTGTCAGTTGTTGGGCTGTAATG
GCGACTGGGCCGCCCCTGACGAAGTGACTCCCGGGCCGGGGAGCGGGGCCAGACCTGCGCCAGAGAGAACTGCAGGGAGCCGCAGCTCGG
GGGGTGGCTTGCCCTGAGGGAGGGGAGGCAGCCTTTCCGCCTTGTCTTCCTTCCCAGCGGACCGGCGGATCCCCGGAGCCGGTGCGAGGA
GGGCACCCGGTGCGTCCCCGGAGCGGGGAGGCCAGGCCGGGCAGCCCTGGGGCCGGTCGGGGCGGCGTCACTGCACCCTCCGCCAGGCTC
CGCGGGATGCACCGTGGTAGCCGAGGGCGGAGGCGACACTCTCAGGTAAATTGGCAGGATGAGGAGCAGCAAATCAAAAGAGGTGCCTTT
ACCAAATCCAAGGAACTCTCAAAGCAAGGATACTGTTCAAGCAGATATAACCACATCGTGGGATGCACTTTCTCAAACCAAGGCTGCTCT
GAGACACATTGAAAATAAATTAGAAGTAGCCCCTACAAGTACAGCTGTGTGTGATTCTGTCATGGATACCAAGAAGTCTTCTACAAGTGC
TACTCGAAAAATAAGTAGAAAAGATGGTAGATACCTGGATGATTCTTGGGTTAATGCTCCAATCTCCAAATCCACTAAATCACGAAAAGA
GAAATCTCGTAGTCCTCTCAGGGCCACCACCCTGGAGAGTAATGTGAAGAAAAATAATCGTGTGGAATTTCGTGAACCTTTGGTTTCTTA
TAGGGAAATCCATGGTGCACCTTCCAATTTCAGTTCCAGCCATCTGGAATCAAAGCACGTATACTGTGTAGATGTTAATGAAGAAAAGAC
TGAGAGCGGTAACTGGATGATAGGCAGTCGAGAAGAACGGAATATACGGAGCTGTGATTTTGAGAGCTCCCAATCATCTGTCATCAATGA
TACAGTTGTTAGGTTTTTAAATGATCGACCAGCAATTGATGCATTGCAAAATTCTGAATGTTTGATTAGGATGGGAGCTTCTATGAGAAC
TGAGGAAGAAATGCCTAACAGAACAAAAGGAAGTGAGAATAATTTGAAGCTTTCTGTGAATAACATGGCCCATGATACTGATCCAAAAGC
GTTACGACTAACTGACTCTTCTCCATCCTCTACTAGTACTTCTAATTCCCAAAGATTAGATATTCTAAAGCGGCGACAACATGATGTCAA
ACTGGAAAAACTTAAGGAACGGATTAGAAAACAGTGGGAACACTCAGAAGAAACAAATGGCCGGGGCCAGAAGCTGGGTCATATTGACCA
TCCAGTAATGGTTGTTAATGTTGATAACTCAGTAACAGCAAAAGTCAGAAAAGTGGCAACAGCACCACCTGCTCCAGCATATAAAGGTTT
CAACCCTTCAGAGACCAAGATTCGAACACCTGATGGGAAAGTGTGGCAGGAGGCTGAGTTTCAAAACATGAGTAGAGAACTGTATCGAGA
TTTAGCACTTCACTTTGCAGATGATATTTCTATAAAGGAGAAACCTGCTGAAAAAAGTAAAGAGAAGAAAGTAGTCAAGCCAGTACGAAA
AGTCCAAAAAGTAGCACAGTTATCAAGTACAGAATGCAGAACAGGTAGTAGTCATCTTATAAGTACATCTTCTTGGCGAGATGGACAAAA
ATTAGTAAAGAAGATTCTGGGACCTGCTCCCAGAATGGAGCCAAAAGAGCAAAGAACAGCATCAAGTGACAGAGGTGGAAGAGAAAGAAC
TGCTAAATCTGGGGGTCACATTGGAAGAGCAGAATCTGATCCCAGGTTGGACGTTTTACATAGACATCTTCAAAGAAACTCAGAACGTTC
GAGAAGTAAATCTCGGTCTGAAAATAATATAAAGAAACTAGCTTCATCTCTTCCAGATAATAAGCAGGAGGAAAATACTGCCTTAAATAA
GGACTTTTTACCTATTGAAATTCGTGGCATTCTTGATGACCTACAGCTGGATTCTACAGCTCACACTGCAAAGCAAGATACTGTAGAGTT
ACAGAACCAGAAGTCATCAGCACCAGTACATGCTCCTAGGAGTCACAGCCCAGTAAAAAGAAAACCTGACAAAATAACAGCTAATGAAGA
TCCCCCTGTTATTTCCAAAAGGCGCCACTATGACACAGATGAGGTACGACAGTACATTGTTAGGCAGCAGGAGGAAAGGAAGAGAAAGCA
AAATGAAGAGAAGAAGGCTCAAAAGGAGGCTACAGAACAGAAAAACAAACGATTACAAGAGCTCTACCGGAAGCAGAAGGAAGCCTTTAC
TAAAGTAAAAAATGTCCCTCCTTCTGAGCCATCAGCAACTAGGCGACTACAGGAAACTTACTCCAAATTGCTACTAGAAAAGACCTTGCT
TGAAGAGCCATCTCATCAACATGTTACGCAGGAAACACAGGCCAAACCAGGGTATCAGCCATCTGGAGAATCTGACAAAGAAAACAAAGT
ACAGGAACGTCCCCCAAGTGCATCTTCCAGTAGTGACATGTCTCTCTCAGAACCTCCACAGCCTCTTGCAAGAAAAGACTTGATGGAATC
TACATGGATGCAGCCTGAAAGATTGAGCCCACAAGTTCACCATTCTCAACCACAGCCTTTTGCTGGAACAGCTGGAAGTTTACTCTCCCA
TCTCTTGAGTTTAGAGCATGTAGGAATTTTGCATAAGGATTTTGAATCTATTTTACCAACCAGGAAGAATCATAATATGGCTTCAAGGCC
ATTAACTTTTACACCTCAACCATATGTGACCTCACCAGCTGCTTATACAGATGCCTTGTTAAAACCTAGTGCCAGCCAATATAAGAGTAA
ACTGGATCGTATTGAAGCCTTGAAAGCAACAGCTGCTTCTTTGTCCAGCAGAATTGAAAGTGAAGCCAAGAAATTAGCTGGGGCCAGCAT
TAACTATGGGTCAGCATGGAACACTGAGTATGATGTGCAGCAGGCACCTCAAGAAGATGGACCTTGGACCAAGGCTGTAACTCCACCTGT
GAAAGATGATAATGAAGATGTTTTCTCTGCCAGAATTCAGAAGATGCTGGGAAGCTGTGTATCTCATGCAACTTTTGATGATGATCTTCC
TGGTGTAGGCAATCTTAGTGAATTTAAAAAGCTTCCTGAGATGATAAGACCACAGAGTGCCATATCAAGCTTTAGAGTGAGATCCCCTGG
TCCCAAACCAGAAGGGCTACTGGCACAGTTATGTAAAAGGCAGACTGACTCTTCTAGCTCTGATATGCAAGCCTGTTCTCAAGACAAAGC
CAAAATATCTCTTGGTTCCAGCATAGATTCAGTCAGTGAAGGGCCTCTTCTTAGTGAGGGGAGTCTCTCTGAAGAAGAGGGAGACCAGGA
TGGACAGCCCCTTTTGAAAGTAGCAGAAATTTTAAAAGAAAAGGAATTTTGTCCTGGAGAAAGAAATAGTTATGAACCCATCAAAGAGTT
TCAGAAAGAAGCTGAAAAATTCTTGCCACTTTTTGGGCACATAGGTGGTACACAAAGCAAAGGACCATGGGAAGAATTGGCAAAGGGAAG
TCCACATAGCGTCATTAATATTTTTACAAAATCCTATCAGTTATATGGAAAAGGGTTTGAAGACAAGTTGGACAGAGGAACATCAACATC
ACGGCCTTTGAATGCCACCGCAACTCCTCTAAGTGGTGTTTCATATGAAGATGATTTTGTCTCCTCTCCAGGGACTGGGACTTCGACAGA
AAAAAAATCAACTCTTGAACCTCATAGCACTTTAAGCCCTCAGGAGGACCATTCTAACAGAAAGTCTGCCTATGATCCTTCCTCTGTGGA
TGTTACCTCCCAGCATTCATCAGGAGCCCAGTCTGCTGCATCGTCTCGTTCATCTACTTCTTCTAAAGGAAAGAAAGGAAAAAAGGAAAA
GACAGAATGGTTGGATTCATTCACTGGAAATGTTCAGAACTCACTTCTTGATGAGGAAAAAGCAGAACGTGGCTCCCATCAAGGAAAGAA
ATCTGGGACCAGCAGCAAACTTTCTGTTAAAGATTTTGAGCAGACTCTTGATACAGATAGCACTTTGGAGGATCTTTCTGGACATTCTGT
GAGTGTCTCATCAGATAAGGGAAGATCTCAGAAAACTCCAACTTCTCCCCTGTCACCAAGTTCCCAGAAATCATTGCAGTTTGACGTTGC
AGGAACTTCTTCAGAAAGATCTAAGTCGTCAGTAATGCCTCCAACTATAACAGGATTTAAGCCTAATGCACCTCTCACTGATCTGAACCC
GGCAGCCAGCAGAACAACGACAGAGAACATGGCTCCAATACCAGGTTCTAAGCGCTTTTCTCCTGCTGGCCTCCATCATCGTATGGCAGC
AGAACTCAGTTATCTGAACGCCATTGAGGAGTCGGTGCGCCAACTGTCAGATGTAGAAAGAGTTAGAGGCATTTCACTTGCTCAGCAGGA
GAGTGTGTCTCTAGCTCAGATAATAAAGGCACAACAGCAACGCCATGAAAGAGACTTGGCCCTCTTGAAACTAAAGGCTGAACAAGAGGC
TCTGGAGAGTCAGAGACAATTAGAAGAAACCCGAAACAAAGCAGCTCAGTGGAAAGCTCACCAGAGATCCTAAAGAATGAAGATTTTTCT
AGCAGCCGTGCTATTACATTGTACAAAGACAAGCGTCAAGAATCTGTAGACCAGCTGTCTTTGATTTTGTCTTATGAGTGCCAGATTTCT
CAGAAGCTCTACATTCCTCGAAGTACAGCCACTGCTGCCTTAGGTGCTGCCGCACGGTTAGCTACATCCAGGAGCCTCCTACACTGGTAC
CCCAGTGTGAAAAGGATGGAAGCATGAGGGAGGGAGGGAGGAGGGAGAAAAACAGAATCCAGCCGCTTAGGCTTTGATGAACTCCCAGGC
CAAAATGAGGAGTTATTGAAGCAAAATAGTATCTTGATCATTGATACTTTTGTCTTTCTGTGACTATATGTTAGCTTTATTATGCTAACA
GTCTACTTTGATGTGTAAGTAAGTATTGATATTTACTGTTAATCTTGATTTTTCTTGATTTTATTCTGTGTCATTTTGTTCACCTTTGTT

>15858_15858_2_CEP350-TDRD5_CEP350_chr1_180010383_ENST00000367607_TDRD5_chr1_179659831_ENST00000367614_length(amino acids)=1414AA_BP=
MRSSKSKEVPLPNPRNSQSKDTVQADITTSWDALSQTKAALRHIENKLEVAPTSTAVCDSVMDTKKSSTSATRKISRKDGRYLDDSWVNA
PISKSTKSRKEKSRSPLRATTLESNVKKNNRVEFREPLVSYREIHGAPSNFSSSHLESKHVYCVDVNEEKTESGNWMIGSREERNIRSCD
FESSQSSVINDTVVRFLNDRPAIDALQNSECLIRMGASMRTEEEMPNRTKGSENNLKLSVNNMAHDTDPKALRLTDSSPSSTSTSNSQRL
DILKRRQHDVKLEKLKERIRKQWEHSEETNGRGQKLGHIDHPVMVVNVDNSVTAKVRKVATAPPAPAYKGFNPSETKIRTPDGKVWQEAE
FQNMSRELYRDLALHFADDISIKEKPAEKSKEKKVVKPVRKVQKVAQLSSTECRTGSSHLISTSSWRDGQKLVKKILGPAPRMEPKEQRT
ASSDRGGRERTAKSGGHIGRAESDPRLDVLHRHLQRNSERSRSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDST
AHTAKQDTVELQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRKQNEEKKAQKEATEQKNKRLQ
ELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKLLLEKTLLEEPSHQHVTQETQAKPGYQPSGESDKENKVQERPPSASSSSDMSLSEPP
QPLARKDLMESTWMQPERLSPQVHHSQPQPFAGTAGSLLSHLLSLEHVGILHKDFESILPTRKNHNMASRPLTFTPQPYVTSPAAYTDAL
LKPSASQYKSKLDRIEALKATAASLSSRIESEAKKLAGASINYGSAWNTEYDVQQAPQEDGPWTKAVTPPVKDDNEDVFSARIQKMLGSC
VSHATFDDDLPGVGNLSEFKKLPEMIRPQSAISSFRVRSPGPKPEGLLAQLCKRQTDSSSSDMQACSQDKAKISLGSSIDSVSEGPLLSE
GSLSEEEGDQDGQPLLKVAEILKEKEFCPGERNSYEPIKEFQKEAEKFLPLFGHIGGTQSKGPWEELAKGSPHSVINIFTKSYQLYGKGF
EDKLDRGTSTSRPLNATATPLSGVSYEDDFVSSPGTGTSTEKKSTLEPHSTLSPQEDHSNRKSAYDPSSVDVTSQHSSGAQSAASSRSST
SSKGKKGKKEKTEWLDSFTGNVQNSLLDEEKAERGSHQGKKSGTSSKLSVKDFEQTLDTDSTLEDLSGHSVSVSSDKGRSQKTPTSPLSP
SSQKSLQFDVAGTSSERSKSSVMPPTITGFKPNAPLTDLNPAASRTTTENMAPIPGSKRFSPAGLHHRMAAELSYLNAIEESVRQLSDVE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CEP350-TDRD5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CEP350-TDRD5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CEP350-TDRD5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource