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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CEP170-SDCCAG8 (FusionGDB2 ID:HG9859TG10806)

Fusion Gene Summary for CEP170-SDCCAG8

Fusion gene summary

Fusion gene information	Fusion gene name: CEP170-SDCCAG8
	Fusion gene ID: hg9859tg10806
		Hgene	Tgene
	Gene symbol	CEP170	SDCCAG8
	Gene ID	9859	10806
	Gene name	centrosomal protein 170	SHH signaling and ciliogenesis regulator SDCCAG8
	Synonyms	FAM68A\|KAB\|KIAA0470	BBS16\|CCCAP\|CCCAP SLSN7\|HSPC085\|NPHP10\|NY-CO-8\|SLSN7\|hCCCAP
	Cytomap	('CEP170')('SDCCAG8') 1q43	1q43-q44
	Type of gene	protein-coding	protein-coding
	Description	centrosomal protein of 170 kDaKARP-1-binding proteinXRCC5 binding proteincentrosomal protein 170kDa	serologically defined colon cancer antigen 8Bardet-Biedl syndrome 16antigen NY-CO-8centrosomal colon cancer autoantigen proteinnephrocystin 10
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000366542, ENST00000366543, ENST00000366544, ENST00000468254, ENST00000481987, ENST00000490813,	ENST00000468254, ENST00000481987, ENST00000490813, ENST00000366542, ENST00000366543, ENST00000366544,
Fusion gene scores	* DoF score	12 X 9 X 10=1080	22 X 19 X 10=4180
	# samples	13	26
	** MAII score	log2(13/1080*10)=-3.05444778402238 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(26/4180*10)=-4.00691941393979 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CEP170 [Title/Abstract] AND SDCCAG8 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CEP170(243418342)-SDCCAG8(243468015), # samples:1 CEP170(243385026)-SDCCAG8(243493842), # samples:1 CEP170(243418349)-SDCCAG8(243468015), # samples:1
Anticipated loss of major functional domain due to fusion event.	CEP170-SDCCAG8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CEP170-SDCCAG8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CEP170-SDCCAG8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CEP170-SDCCAG8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SDCCAG8-CEP170 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CEP170 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SDCCAG8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-73-4662-01A	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
ChimerDB4	LUAD	TCGA-73-4662-01A	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
ChimerDB4	OV	TCGA-24-1469-01A	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+

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Fusion Gene ORF analysis for CEP170-SDCCAG8

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000366542	ENST00000391846	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
5CDS-intron	ENST00000366542	ENST00000496361	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
5CDS-intron	ENST00000366543	ENST00000391846	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
5CDS-intron	ENST00000366543	ENST00000496361	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
5CDS-intron	ENST00000366544	ENST00000391846	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
5CDS-intron	ENST00000366544	ENST00000496361	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
5UTR-3CDS	ENST00000366542	ENST00000343783	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
5UTR-3CDS	ENST00000366542	ENST00000355875	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
5UTR-3CDS	ENST00000366542	ENST00000366541	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
5UTR-3CDS	ENST00000366542	ENST00000391846	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
5UTR-3CDS	ENST00000366543	ENST00000343783	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
5UTR-3CDS	ENST00000366543	ENST00000355875	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
5UTR-3CDS	ENST00000366543	ENST00000366541	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
5UTR-3CDS	ENST00000366543	ENST00000391846	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
5UTR-3CDS	ENST00000366544	ENST00000343783	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
5UTR-3CDS	ENST00000366544	ENST00000355875	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
5UTR-3CDS	ENST00000366544	ENST00000366541	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
5UTR-3CDS	ENST00000366544	ENST00000391846	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
5UTR-3UTR	ENST00000366542	ENST00000496361	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
5UTR-3UTR	ENST00000366543	ENST00000496361	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
5UTR-3UTR	ENST00000366544	ENST00000496361	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
In-frame	ENST00000366542	ENST00000343783	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
In-frame	ENST00000366542	ENST00000355875	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
In-frame	ENST00000366542	ENST00000366541	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
In-frame	ENST00000366543	ENST00000343783	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
In-frame	ENST00000366543	ENST00000355875	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
In-frame	ENST00000366543	ENST00000366541	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
In-frame	ENST00000366544	ENST00000343783	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
In-frame	ENST00000366544	ENST00000355875	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
In-frame	ENST00000366544	ENST00000366541	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
intron-3CDS	ENST00000366542	ENST00000343783	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000366542	ENST00000355875	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000366542	ENST00000366541	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000366542	ENST00000391846	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000366543	ENST00000343783	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000366543	ENST00000355875	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000366543	ENST00000366541	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000366543	ENST00000391846	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000366544	ENST00000343783	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000366544	ENST00000355875	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000366544	ENST00000366541	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000366544	ENST00000391846	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000468254	ENST00000343783	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000468254	ENST00000343783	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000468254	ENST00000343783	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
intron-3CDS	ENST00000468254	ENST00000355875	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000468254	ENST00000355875	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000468254	ENST00000355875	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
intron-3CDS	ENST00000468254	ENST00000366541	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000468254	ENST00000366541	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000468254	ENST00000366541	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
intron-3CDS	ENST00000468254	ENST00000391846	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000468254	ENST00000391846	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000481987	ENST00000343783	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000481987	ENST00000343783	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000481987	ENST00000343783	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
intron-3CDS	ENST00000481987	ENST00000355875	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000481987	ENST00000355875	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000481987	ENST00000355875	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
intron-3CDS	ENST00000481987	ENST00000366541	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000481987	ENST00000366541	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000481987	ENST00000366541	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
intron-3CDS	ENST00000481987	ENST00000391846	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000481987	ENST00000391846	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000490813	ENST00000343783	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000490813	ENST00000343783	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000490813	ENST00000343783	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
intron-3CDS	ENST00000490813	ENST00000355875	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000490813	ENST00000355875	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000490813	ENST00000355875	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
intron-3CDS	ENST00000490813	ENST00000366541	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000490813	ENST00000366541	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000490813	ENST00000366541	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
intron-3CDS	ENST00000490813	ENST00000391846	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
intron-3CDS	ENST00000490813	ENST00000391846	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3UTR	ENST00000366542	ENST00000496361	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3UTR	ENST00000366543	ENST00000496361	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3UTR	ENST00000366544	ENST00000496361	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3UTR	ENST00000468254	ENST00000496361	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
intron-3UTR	ENST00000468254	ENST00000496361	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3UTR	ENST00000481987	ENST00000496361	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
intron-3UTR	ENST00000481987	ENST00000496361	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-3UTR	ENST00000490813	ENST00000496361	CEP170	chr1	243418342	-	SDCCAG8	chr1	243468015	+
intron-3UTR	ENST00000490813	ENST00000496361	CEP170	chr1	243418349	-	SDCCAG8	chr1	243468015	+
intron-intron	ENST00000468254	ENST00000391846	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
intron-intron	ENST00000468254	ENST00000496361	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
intron-intron	ENST00000481987	ENST00000391846	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
intron-intron	ENST00000481987	ENST00000496361	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
intron-intron	ENST00000490813	ENST00000391846	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+
intron-intron	ENST00000490813	ENST00000496361	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000366542	CEP170	chr1	243385026	-	ENST00000355875	SDCCAG8	chr1	243493842	+	1622	247	52	1320	422
ENST00000366542	CEP170	chr1	243385026	-	ENST00000366541	SDCCAG8	chr1	243493842	+	1628	247	52	1320	422
ENST00000366542	CEP170	chr1	243385026	-	ENST00000343783	SDCCAG8	chr1	243493842	+	1626	247	52	1320	422
ENST00000366543	CEP170	chr1	243385026	-	ENST00000355875	SDCCAG8	chr1	243493842	+	1893	518	323	1591	422
ENST00000366543	CEP170	chr1	243385026	-	ENST00000366541	SDCCAG8	chr1	243493842	+	1899	518	323	1591	422
ENST00000366543	CEP170	chr1	243385026	-	ENST00000343783	SDCCAG8	chr1	243493842	+	1897	518	323	1591	422
ENST00000366544	CEP170	chr1	243385026	-	ENST00000355875	SDCCAG8	chr1	243493842	+	1893	518	323	1591	422
ENST00000366544	CEP170	chr1	243385026	-	ENST00000366541	SDCCAG8	chr1	243493842	+	1899	518	323	1591	422
ENST00000366544	CEP170	chr1	243385026	-	ENST00000343783	SDCCAG8	chr1	243493842	+	1897	518	323	1591	422

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000366542	ENST00000355875	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+	0.005112497	0.99488753
ENST00000366542	ENST00000366541	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+	0.005107733	0.99489224
ENST00000366542	ENST00000343783	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+	0.005073337	0.9949267
ENST00000366543	ENST00000355875	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+	0.004257865	0.99574214
ENST00000366543	ENST00000366541	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+	0.004175642	0.99582434
ENST00000366543	ENST00000343783	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+	0.004171621	0.99582833
ENST00000366544	ENST00000355875	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+	0.004257865	0.99574214
ENST00000366544	ENST00000366541	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+	0.004175642	0.99582434
ENST00000366544	ENST00000343783	CEP170	chr1	243385026	-	SDCCAG8	chr1	243493842	+	0.004171621	0.99582833

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Fusion Genomic Features for CEP170-SDCCAG8

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CEP170	chr1	243418341	-	SDCCAG8	chr1	243468014	+	2.40E-06	0.9999976
CEP170	chr1	243385025	-	SDCCAG8	chr1	243493841	+	2.56E-08	1
CEP170	chr1	243418341	-	SDCCAG8	chr1	243468014	+	2.40E-06	0.9999976
CEP170	chr1	243385025	-	SDCCAG8	chr1	243493841	+	2.56E-08	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CEP170-SDCCAG8

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:243418342/chr1:243468015)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SDCCAG8

chr1:243385026

chr1:243493842

ENST00000391846

129_175

361.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SDCCAG8

chr1:243385026

chr1:243493842

ENST00000391846

223_273

361.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SDCCAG8

chr1:243385026

chr1:243493842

ENST00000391846

348_707

361.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SDCCAG8

chr1:243385026

chr1:243493842

ENST00000366541

534_692

356

714.0

Compositional bias

Note=Gln-rich

Tgene

SDCCAG8

chr1:243385026

chr1:243493842

ENST00000391846

534_692

361.0

Compositional bias

Note=Gln-rich

Tgene

SDCCAG8

chr1:243385026

chr1:243493842

ENST00000391846

216_713

361.0

Region

Sufficient for homodimerization

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CEP170

chr1:243385026

chr1:243493842

ENST00000366542

1467_1495

1585.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP170

chr1:243385026

chr1:243493842

ENST00000366543

1467_1495

1461.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP170

chr1:243385026

chr1:243493842

ENST00000366544

1467_1495

1487.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP170

chr1:243385026

chr1:243493842

ENST00000366542

23_73

1585.0

Domain

FHA

Hgene

CEP170

chr1:243385026

chr1:243493842

ENST00000366543

23_73

1461.0

Domain

FHA

Hgene

CEP170

chr1:243385026

chr1:243493842

ENST00000366544

23_73

1487.0

Domain

FHA

Hgene

CEP170

chr1:243385026

chr1:243493842

ENST00000366542

1113_1584

1585.0

Region

Note=Targeting to centrosomes

Hgene

CEP170

chr1:243385026

chr1:243493842

ENST00000366542

853_1584

1585.0

Region

Note=Targeting to microtubules

Hgene

CEP170

chr1:243385026

chr1:243493842

ENST00000366543

1113_1584

1461.0

Region

Note=Targeting to centrosomes

Hgene

CEP170

chr1:243385026

chr1:243493842

ENST00000366543

853_1584

1461.0

Region

Note=Targeting to microtubules

Hgene

CEP170

chr1:243385026

chr1:243493842

ENST00000366544

1113_1584

1487.0

Region

Note=Targeting to centrosomes

Hgene

CEP170

chr1:243385026

chr1:243493842

ENST00000366544

853_1584

1487.0

Region

Note=Targeting to microtubules

Tgene

SDCCAG8

chr1:243385026

chr1:243493842

ENST00000366541

129_175

356

714.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SDCCAG8

chr1:243385026

chr1:243493842

ENST00000366541

223_273

356

714.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SDCCAG8

chr1:243385026

chr1:243493842

ENST00000366541

348_707

356

714.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SDCCAG8

chr1:243385026

chr1:243493842

ENST00000366541

216_713

356

714.0

Region

Sufficient for homodimerization

Top

Fusion Gene Sequence for CEP170-SDCCAG8

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>15805_15805_1_CEP170-SDCCAG8_CEP170_chr1_243385026_ENST00000366542_SDCCAG8_chr1_243493842_ENST00000343783_length(transcript)=1626nt_BP=247nt
CACGGTAAGGGGATGACGTAGCTTTGCCAAAGACTTAGAAGCTAAGCAGAAAATGAGCTTAACATCCTGGTTTTTGGTGAGCAGTGGAGG
CACTCGCCACAGGCTGCCACGAGAAATGATTTTTGTTGGAAGAGATGACTGTGAGCTCATGTTGCAGTCTCGTAGTGTGGATAAGCAACA
CGCTGTCATCAACTATGATGCGTCTACGGATGAGCATTTAGTGAAGGATTTGGGCAGCCTCAATGGGGCTTTAATCCAGTGTGACCAGTT
GAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGAA
AAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAAA
GGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGTG
TGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACAG
GGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGGC
AGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATAG
CATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAAT
GGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTG
TACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAA
ATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAG
GCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCT
GTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGAT
TTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCA
GTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGT
GTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGCTAGGTTATACATATGATTTTCAATAAATGAACTTT

>15805_15805_1_CEP170-SDCCAG8_CEP170_chr1_243385026_ENST00000366542_SDCCAG8_chr1_243493842_ENST00000343783_length(amino acids)=422AA_BP=65
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGALIQCDQLRKELERQAERLEKELAS
QQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEA
EKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQ
QREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQ

--------------------------------------------------------------
>15805_15805_2_CEP170-SDCCAG8_CEP170_chr1_243385026_ENST00000366542_SDCCAG8_chr1_243493842_ENST00000355875_length(transcript)=1622nt_BP=247nt
CACGGTAAGGGGATGACGTAGCTTTGCCAAAGACTTAGAAGCTAAGCAGAAAATGAGCTTAACATCCTGGTTTTTGGTGAGCAGTGGAGG
CACTCGCCACAGGCTGCCACGAGAAATGATTTTTGTTGGAAGAGATGACTGTGAGCTCATGTTGCAGTCTCGTAGTGTGGATAAGCAACA
CGCTGTCATCAACTATGATGCGTCTACGGATGAGCATTTAGTGAAGGATTTGGGCAGCCTCAATGGGGCTTTAATCCAGTGTGACCAGTT
GAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGAA
AAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAAA
GGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGTG
TGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACAG
GGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGGC
AGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATAG
CATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAAT
GGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTG
TACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAA
ATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAG
GCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCT
GTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGAT
TTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCA
GTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGT
GTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGCTAGGTTATACATATGATTTTCAATAAATGAACTTT

>15805_15805_2_CEP170-SDCCAG8_CEP170_chr1_243385026_ENST00000366542_SDCCAG8_chr1_243493842_ENST00000355875_length(amino acids)=422AA_BP=65
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGALIQCDQLRKELERQAERLEKELAS
QQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEA
EKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQ
QREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQ

--------------------------------------------------------------
>15805_15805_3_CEP170-SDCCAG8_CEP170_chr1_243385026_ENST00000366542_SDCCAG8_chr1_243493842_ENST00000366541_length(transcript)=1628nt_BP=247nt
CACGGTAAGGGGATGACGTAGCTTTGCCAAAGACTTAGAAGCTAAGCAGAAAATGAGCTTAACATCCTGGTTTTTGGTGAGCAGTGGAGG
CACTCGCCACAGGCTGCCACGAGAAATGATTTTTGTTGGAAGAGATGACTGTGAGCTCATGTTGCAGTCTCGTAGTGTGGATAAGCAACA
CGCTGTCATCAACTATGATGCGTCTACGGATGAGCATTTAGTGAAGGATTTGGGCAGCCTCAATGGGGCTTTAATCCAGTGTGACCAGTT
GAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGAA
AAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAAA
GGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGTG
TGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACAG
GGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGGC
AGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATAG
CATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAAT
GGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTG
TACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAA
ATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAG
GCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCT
GTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGAT
TTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCA
GTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGT
GTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGCTAGGTTATACATATGATTTTCAATAAATGAACTTT

>15805_15805_3_CEP170-SDCCAG8_CEP170_chr1_243385026_ENST00000366542_SDCCAG8_chr1_243493842_ENST00000366541_length(amino acids)=422AA_BP=65
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGALIQCDQLRKELERQAERLEKELAS
QQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEA
EKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQ
QREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQ

--------------------------------------------------------------
>15805_15805_4_CEP170-SDCCAG8_CEP170_chr1_243385026_ENST00000366543_SDCCAG8_chr1_243493842_ENST00000343783_length(transcript)=1897nt_BP=518nt
TTGGAACTGGGCAGGAGGGGATAGGGTCCGGCTCCTCGCCCTTTCCCGAGGCGCCTGCGCACTAGGCAGTCGGTCTTTGCCGTTACCGCT
ATGTGTGGGGCGTGTGTGGAATAACGTTATTGCCCAGCGGAGCTGAGGGCCCCGGAGCTCGACCGCAGCGGCAGCGACGACAACAGCGGC
GACGACGACGACGACGAGGTGGGGGGAGGACGGCGTGCGAGAGACTCACGGGACGCGACGCGCCCCGCCTCCCCCGTCCGGTCCCTCTCT
CCACGGTAAGGGGATGACGTAGCTTTGCCAAAGACTTAGAAGCTAAGCAGAAAATGAGCTTAACATCCTGGTTTTTGGTGAGCAGTGGAG
GCACTCGCCACAGGCTGCCACGAGAAATGATTTTTGTTGGAAGAGATGACTGTGAGCTCATGTTGCAGTCTCGTAGTGTGGATAAGCAAC
ACGCTGTCATCAACTATGATGCGTCTACGGATGAGCATTTAGTGAAGGATTTGGGCAGCCTCAATGGGGCTTTAATCCAGTGTGACCAGT
TGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGA
AAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAA
AGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGT
GTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACA
GGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGG
CAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATA
GCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAA
TGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCT
GTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATA
AATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAA
GGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCC
TGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGA
TTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGC
AGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGG
TGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGCTAGGTTATACATATGATTTTCAATAAATGAACTT

>15805_15805_4_CEP170-SDCCAG8_CEP170_chr1_243385026_ENST00000366543_SDCCAG8_chr1_243493842_ENST00000343783_length(amino acids)=422AA_BP=65
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGALIQCDQLRKELERQAERLEKELAS
QQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEA
EKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQ
QREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQ

--------------------------------------------------------------
>15805_15805_5_CEP170-SDCCAG8_CEP170_chr1_243385026_ENST00000366543_SDCCAG8_chr1_243493842_ENST00000355875_length(transcript)=1893nt_BP=518nt
TTGGAACTGGGCAGGAGGGGATAGGGTCCGGCTCCTCGCCCTTTCCCGAGGCGCCTGCGCACTAGGCAGTCGGTCTTTGCCGTTACCGCT
ATGTGTGGGGCGTGTGTGGAATAACGTTATTGCCCAGCGGAGCTGAGGGCCCCGGAGCTCGACCGCAGCGGCAGCGACGACAACAGCGGC
GACGACGACGACGACGAGGTGGGGGGAGGACGGCGTGCGAGAGACTCACGGGACGCGACGCGCCCCGCCTCCCCCGTCCGGTCCCTCTCT
CCACGGTAAGGGGATGACGTAGCTTTGCCAAAGACTTAGAAGCTAAGCAGAAAATGAGCTTAACATCCTGGTTTTTGGTGAGCAGTGGAG
GCACTCGCCACAGGCTGCCACGAGAAATGATTTTTGTTGGAAGAGATGACTGTGAGCTCATGTTGCAGTCTCGTAGTGTGGATAAGCAAC
ACGCTGTCATCAACTATGATGCGTCTACGGATGAGCATTTAGTGAAGGATTTGGGCAGCCTCAATGGGGCTTTAATCCAGTGTGACCAGT
TGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGA
AAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAA
AGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGT
GTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACA
GGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGG
CAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATA
GCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAA
TGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCT
GTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATA
AATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAA
GGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCC
TGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGA
TTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGC
AGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGG
TGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGCTAGGTTATACATATGATTTTCAATAAATGAACTT

>15805_15805_5_CEP170-SDCCAG8_CEP170_chr1_243385026_ENST00000366543_SDCCAG8_chr1_243493842_ENST00000355875_length(amino acids)=422AA_BP=65
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGALIQCDQLRKELERQAERLEKELAS
QQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEA
EKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQ
QREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQ

--------------------------------------------------------------
>15805_15805_6_CEP170-SDCCAG8_CEP170_chr1_243385026_ENST00000366543_SDCCAG8_chr1_243493842_ENST00000366541_length(transcript)=1899nt_BP=518nt
TTGGAACTGGGCAGGAGGGGATAGGGTCCGGCTCCTCGCCCTTTCCCGAGGCGCCTGCGCACTAGGCAGTCGGTCTTTGCCGTTACCGCT
ATGTGTGGGGCGTGTGTGGAATAACGTTATTGCCCAGCGGAGCTGAGGGCCCCGGAGCTCGACCGCAGCGGCAGCGACGACAACAGCGGC
GACGACGACGACGACGAGGTGGGGGGAGGACGGCGTGCGAGAGACTCACGGGACGCGACGCGCCCCGCCTCCCCCGTCCGGTCCCTCTCT
CCACGGTAAGGGGATGACGTAGCTTTGCCAAAGACTTAGAAGCTAAGCAGAAAATGAGCTTAACATCCTGGTTTTTGGTGAGCAGTGGAG
GCACTCGCCACAGGCTGCCACGAGAAATGATTTTTGTTGGAAGAGATGACTGTGAGCTCATGTTGCAGTCTCGTAGTGTGGATAAGCAAC
ACGCTGTCATCAACTATGATGCGTCTACGGATGAGCATTTAGTGAAGGATTTGGGCAGCCTCAATGGGGCTTTAATCCAGTGTGACCAGT
TGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGA
AAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAA
AGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGT
GTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACA
GGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGG
CAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATA
GCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAA
TGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCT
GTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATA
AATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAA
GGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCC
TGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGA
TTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGC
AGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGG
TGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGCTAGGTTATACATATGATTTTCAATAAATGAACTT

>15805_15805_6_CEP170-SDCCAG8_CEP170_chr1_243385026_ENST00000366543_SDCCAG8_chr1_243493842_ENST00000366541_length(amino acids)=422AA_BP=65
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGALIQCDQLRKELERQAERLEKELAS
QQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEA
EKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQ
QREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQ

--------------------------------------------------------------
>15805_15805_7_CEP170-SDCCAG8_CEP170_chr1_243385026_ENST00000366544_SDCCAG8_chr1_243493842_ENST00000343783_length(transcript)=1897nt_BP=518nt
TTGGAACTGGGCAGGAGGGGATAGGGTCCGGCTCCTCGCCCTTTCCCGAGGCGCCTGCGCACTAGGCAGTCGGTCTTTGCCGTTACCGCT
ATGTGTGGGGCGTGTGTGGAATAACGTTATTGCCCAGCGGAGCTGAGGGCCCCGGAGCTCGACCGCAGCGGCAGCGACGACAACAGCGGC
GACGACGACGACGACGAGGTGGGGGGAGGACGGCGTGCGAGAGACTCACGGGACGCGACGCGCCCCGCCTCCCCCGTCCGGTCCCTCTCT
CCACGGTAAGGGGATGACGTAGCTTTGCCAAAGACTTAGAAGCTAAGCAGAAAATGAGCTTAACATCCTGGTTTTTGGTGAGCAGTGGAG
GCACTCGCCACAGGCTGCCACGAGAAATGATTTTTGTTGGAAGAGATGACTGTGAGCTCATGTTGCAGTCTCGTAGTGTGGATAAGCAAC
ACGCTGTCATCAACTATGATGCGTCTACGGATGAGCATTTAGTGAAGGATTTGGGCAGCCTCAATGGGGCTTTAATCCAGTGTGACCAGT
TGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGA
AAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAA
AGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGT
GTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACA
GGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGG
CAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATA
GCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAA
TGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCT
GTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATA
AATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAA
GGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCC
TGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGA
TTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGC
AGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGG
TGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGCTAGGTTATACATATGATTTTCAATAAATGAACTT

>15805_15805_7_CEP170-SDCCAG8_CEP170_chr1_243385026_ENST00000366544_SDCCAG8_chr1_243493842_ENST00000343783_length(amino acids)=422AA_BP=65
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGALIQCDQLRKELERQAERLEKELAS
QQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEA
EKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQ
QREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQ

--------------------------------------------------------------
>15805_15805_8_CEP170-SDCCAG8_CEP170_chr1_243385026_ENST00000366544_SDCCAG8_chr1_243493842_ENST00000355875_length(transcript)=1893nt_BP=518nt
TTGGAACTGGGCAGGAGGGGATAGGGTCCGGCTCCTCGCCCTTTCCCGAGGCGCCTGCGCACTAGGCAGTCGGTCTTTGCCGTTACCGCT
ATGTGTGGGGCGTGTGTGGAATAACGTTATTGCCCAGCGGAGCTGAGGGCCCCGGAGCTCGACCGCAGCGGCAGCGACGACAACAGCGGC
GACGACGACGACGACGAGGTGGGGGGAGGACGGCGTGCGAGAGACTCACGGGACGCGACGCGCCCCGCCTCCCCCGTCCGGTCCCTCTCT
CCACGGTAAGGGGATGACGTAGCTTTGCCAAAGACTTAGAAGCTAAGCAGAAAATGAGCTTAACATCCTGGTTTTTGGTGAGCAGTGGAG
GCACTCGCCACAGGCTGCCACGAGAAATGATTTTTGTTGGAAGAGATGACTGTGAGCTCATGTTGCAGTCTCGTAGTGTGGATAAGCAAC
ACGCTGTCATCAACTATGATGCGTCTACGGATGAGCATTTAGTGAAGGATTTGGGCAGCCTCAATGGGGCTTTAATCCAGTGTGACCAGT
TGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGA
AAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAA
AGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGT
GTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACA
GGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGG
CAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATA
GCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAA
TGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCT
GTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATA
AATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAA
GGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCC
TGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGA
TTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGC
AGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGG
TGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGCTAGGTTATACATATGATTTTCAATAAATGAACTT

>15805_15805_8_CEP170-SDCCAG8_CEP170_chr1_243385026_ENST00000366544_SDCCAG8_chr1_243493842_ENST00000355875_length(amino acids)=422AA_BP=65
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGALIQCDQLRKELERQAERLEKELAS
QQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEA
EKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQ
QREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQ

--------------------------------------------------------------
>15805_15805_9_CEP170-SDCCAG8_CEP170_chr1_243385026_ENST00000366544_SDCCAG8_chr1_243493842_ENST00000366541_length(transcript)=1899nt_BP=518nt
TTGGAACTGGGCAGGAGGGGATAGGGTCCGGCTCCTCGCCCTTTCCCGAGGCGCCTGCGCACTAGGCAGTCGGTCTTTGCCGTTACCGCT
ATGTGTGGGGCGTGTGTGGAATAACGTTATTGCCCAGCGGAGCTGAGGGCCCCGGAGCTCGACCGCAGCGGCAGCGACGACAACAGCGGC
GACGACGACGACGACGAGGTGGGGGGAGGACGGCGTGCGAGAGACTCACGGGACGCGACGCGCCCCGCCTCCCCCGTCCGGTCCCTCTCT
CCACGGTAAGGGGATGACGTAGCTTTGCCAAAGACTTAGAAGCTAAGCAGAAAATGAGCTTAACATCCTGGTTTTTGGTGAGCAGTGGAG
GCACTCGCCACAGGCTGCCACGAGAAATGATTTTTGTTGGAAGAGATGACTGTGAGCTCATGTTGCAGTCTCGTAGTGTGGATAAGCAAC
ACGCTGTCATCAACTATGATGCGTCTACGGATGAGCATTTAGTGAAGGATTTGGGCAGCCTCAATGGGGCTTTAATCCAGTGTGACCAGT
TGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGA
AAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAA
AGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGT
GTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACA
GGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGG
CAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATA
GCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAA
TGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCT
GTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATA
AATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAA
GGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCC
TGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGA
TTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGC
AGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGG
TGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGCTAGGTTATACATATGATTTTCAATAAATGAACTT

>15805_15805_9_CEP170-SDCCAG8_CEP170_chr1_243385026_ENST00000366544_SDCCAG8_chr1_243493842_ENST00000366541_length(amino acids)=422AA_BP=65
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGALIQCDQLRKELERQAERLEKELAS
QQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEA
EKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQ
QREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CEP170-SDCCAG8

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	CEP170	chr1:243385026	chr1:243493842	ENST00000366542	-	3	20	1015_1460	65.0	1585.0	CCDC61
Hgene	CEP170	chr1:243385026	chr1:243493842	ENST00000366543	-	3	19	1015_1460	65.0	1461.0	CCDC61
Hgene	CEP170	chr1:243385026	chr1:243493842	ENST00000366544	-	3	19	1015_1460	65.0	1487.0	CCDC61

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CEP170-SDCCAG8

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CEP170-SDCCAG8

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene		C3150877	SENIOR-LOKEN SYNDROME 7	3	GENOMICS_ENGLAND
Tgene		C3889474	BARDET-BIEDL SYNDROME 16	3	CTD_human;GENOMICS_ENGLAND
Tgene		C0403553	Renal dysplasia and retinal aplasia (disorder)	2	GENOMICS_ENGLAND;ORPHANET
Tgene		C0752166	Bardet-Biedl Syndrome	2	GENOMICS_ENGLAND;ORPHANET
Tgene		C0022679	Cystic kidney	1	CTD_human
Tgene		C0035309	Retinal Diseases	1	CTD_human
Tgene		C0036341	Schizophrenia	1	PSYGENET
Tgene		C1691228	Cystic Kidney Diseases	1	CTD_human
Tgene		C3714756	Intellectual Disability	1	GENOMICS_ENGLAND

Fusion Gene Studies in Kim Lab

Fusion gene:CEP170-SDCCAG8 (FusionGDB2 ID:HG9859TG10806)

Fusion Gene Summary for CEP170-SDCCAG8

Fusion Gene ORF analysis for CEP170-SDCCAG8

Fusion Genomic Features for CEP170-SDCCAG8

Fusion Protein Features for CEP170-SDCCAG8

Fusion Gene Sequence for CEP170-SDCCAG8

Fusion Gene PPI Analysis for CEP170-SDCCAG8

Related Drugs for CEP170-SDCCAG8

Related Diseases for CEP170-SDCCAG8

Fusion Gene Studies
in Kim Lab