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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FCHSD2-ALG5 (FusionGDB2 ID:HG9873TG29880)

Fusion Gene Summary for FCHSD2-ALG5

check button Fusion gene summary
Fusion gene informationFusion gene name: FCHSD2-ALG5
Fusion gene ID: hg9873tg29880
HgeneTgene
Gene symbol

FCHSD2

ALG5

Gene ID

9873

29880

Gene nameFCH and double SH3 domains 2ALG5 dolichyl-phosphate beta-glucosyltransferase
SynonymsNWK|NWK1|SH3MD3bA421P11.2
Cytomap('FCHSD2')('ALG5')

11q13.4

13q13.3

Type of geneprotein-codingprotein-coding
DescriptionF-BAR and double SH3 domains protein 2FCH and double SH3 domains protein 2SH3 multiple domains 3SH3 multiple domains protein 3caromnervous wreck homologprotein nervous wreck 1dolichyl-phosphate beta-glucosyltransferaseAlg5, S. cerevisiae, homolog ofasparagine-linked glycosylation 5 homolog (S. cerevisiae, dolichyl-phosphate beta-glucosyltransferase)asparagine-linked glycosylation 5 homolog (yeast, dolichyl-phosphate beta-gl
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000409314, ENST00000409418, 
ENST00000311172, ENST00000409853, 
ENST00000458644, ENST00000409263, 
Fusion gene scores* DoF score43 X 26 X 16=178886 X 5 X 5=150
# samples 596
** MAII scorelog2(59/17888*10)=-4.92213332859399
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FCHSD2 [Title/Abstract] AND ALG5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFCHSD2(72794739)-ALG5(37546173), # samples:1
Anticipated loss of major functional domain due to fusion event.FCHSD2-ALG5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FCHSD2-ALG5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FCHSD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ALG5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer61NFCHSD2chr11

72794739

-ALG5chr13

37546173

-


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Fusion Gene ORF analysis for FCHSD2-ALG5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000409314ENST00000496689FCHSD2chr11

72794739

-ALG5chr13

37546173

-
5CDS-intronENST00000409418ENST00000496689FCHSD2chr11

72794739

-ALG5chr13

37546173

-
5UTR-3CDSENST00000311172ENST00000239891FCHSD2chr11

72794739

-ALG5chr13

37546173

-
5UTR-3CDSENST00000311172ENST00000413537FCHSD2chr11

72794739

-ALG5chr13

37546173

-
5UTR-3CDSENST00000311172ENST00000443765FCHSD2chr11

72794739

-ALG5chr13

37546173

-
5UTR-3CDSENST00000409853ENST00000239891FCHSD2chr11

72794739

-ALG5chr13

37546173

-
5UTR-3CDSENST00000409853ENST00000413537FCHSD2chr11

72794739

-ALG5chr13

37546173

-
5UTR-3CDSENST00000409853ENST00000443765FCHSD2chr11

72794739

-ALG5chr13

37546173

-
5UTR-3CDSENST00000458644ENST00000239891FCHSD2chr11

72794739

-ALG5chr13

37546173

-
5UTR-3CDSENST00000458644ENST00000413537FCHSD2chr11

72794739

-ALG5chr13

37546173

-
5UTR-3CDSENST00000458644ENST00000443765FCHSD2chr11

72794739

-ALG5chr13

37546173

-
5UTR-intronENST00000311172ENST00000496689FCHSD2chr11

72794739

-ALG5chr13

37546173

-
5UTR-intronENST00000409853ENST00000496689FCHSD2chr11

72794739

-ALG5chr13

37546173

-
5UTR-intronENST00000458644ENST00000496689FCHSD2chr11

72794739

-ALG5chr13

37546173

-
In-frameENST00000409314ENST00000239891FCHSD2chr11

72794739

-ALG5chr13

37546173

-
In-frameENST00000409314ENST00000413537FCHSD2chr11

72794739

-ALG5chr13

37546173

-
In-frameENST00000409314ENST00000443765FCHSD2chr11

72794739

-ALG5chr13

37546173

-
In-frameENST00000409418ENST00000239891FCHSD2chr11

72794739

-ALG5chr13

37546173

-
In-frameENST00000409418ENST00000413537FCHSD2chr11

72794739

-ALG5chr13

37546173

-
In-frameENST00000409418ENST00000443765FCHSD2chr11

72794739

-ALG5chr13

37546173

-
intron-3CDSENST00000409263ENST00000239891FCHSD2chr11

72794739

-ALG5chr13

37546173

-
intron-3CDSENST00000409263ENST00000413537FCHSD2chr11

72794739

-ALG5chr13

37546173

-
intron-3CDSENST00000409263ENST00000443765FCHSD2chr11

72794739

-ALG5chr13

37546173

-
intron-intronENST00000409263ENST00000496689FCHSD2chr11

72794739

-ALG5chr13

37546173

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409314FCHSD2chr1172794739-ENST00000443765ALG5chr1337546173-915334169747192
ENST00000409314FCHSD2chr1172794739-ENST00000239891ALG5chr1337546173-860334169747192
ENST00000409314FCHSD2chr1172794739-ENST00000413537ALG5chr1337546173-801334437799121
ENST00000409418FCHSD2chr1172794739-ENST00000443765ALG5chr1337546173-1130549384962192
ENST00000409418FCHSD2chr1172794739-ENST00000239891ALG5chr1337546173-1075549384962192
ENST00000409418FCHSD2chr1172794739-ENST00000413537ALG5chr1337546173-10165494332144

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409314ENST00000443765FCHSD2chr1172794739-ALG5chr1337546173-0.0041106610.99588937
ENST00000409314ENST00000239891FCHSD2chr1172794739-ALG5chr1337546173-0.0038890770.996111
ENST00000409314ENST00000413537FCHSD2chr1172794739-ALG5chr1337546173-0.028781690.97121835
ENST00000409418ENST00000443765FCHSD2chr1172794739-ALG5chr1337546173-0.0071579850.9928421
ENST00000409418ENST00000239891FCHSD2chr1172794739-ALG5chr1337546173-0.007144270.99285567
ENST00000409418ENST00000413537FCHSD2chr1172794739-ALG5chr1337546173-0.030626260.9693738

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Fusion Genomic Features for FCHSD2-ALG5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for FCHSD2-ALG5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:72794739/chr13:37546173)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFCHSD2chr11:72794739chr13:37546173ENST00000311172-219356_3970685.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72794739chr13:37546173ENST00000409418-320356_39755741.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72794739chr13:37546173ENST00000409853-216356_3970516.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72794739chr13:37546173ENST00000311172-219718_7210685.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72794739chr13:37546173ENST00000409418-320718_72155741.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72794739chr13:37546173ENST00000409853-216718_7210516.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72794739chr13:37546173ENST00000311172-219469_5300685.0DomainSH3 1
HgeneFCHSD2chr11:72794739chr13:37546173ENST00000311172-2198_2820685.0DomainF-BAR
HgeneFCHSD2chr11:72794739chr13:37546173ENST00000409418-320469_53055741.0DomainSH3 1
HgeneFCHSD2chr11:72794739chr13:37546173ENST00000409418-3208_28255741.0DomainF-BAR
HgeneFCHSD2chr11:72794739chr13:37546173ENST00000409853-216469_5300516.0DomainSH3 1
HgeneFCHSD2chr11:72794739chr13:37546173ENST00000409853-2168_2820516.0DomainF-BAR
HgeneFCHSD2chr11:72794739chr13:37546173ENST00000311172-219567_6290685.0RegionRequired and sufficient for location at clathrin-coated pits
HgeneFCHSD2chr11:72794739chr13:37546173ENST00000409418-320567_62955741.0RegionRequired and sufficient for location at clathrin-coated pits
HgeneFCHSD2chr11:72794739chr13:37546173ENST00000409853-216567_6290516.0RegionRequired and sufficient for location at clathrin-coated pits
TgeneALG5chr11:72794739chr13:37546173ENST000002398915101_7187325.0Topological domainCytoplasmic
TgeneALG5chr11:72794739chr13:37546173ENST0000023989151029_324187325.0Topological domainLumenal
TgeneALG5chr11:72794739chr13:37546173ENST00000443765491_7157295.0Topological domainCytoplasmic
TgeneALG5chr11:72794739chr13:37546173ENST000004437654929_324157295.0Topological domainLumenal
TgeneALG5chr11:72794739chr13:37546173ENST000002398915108_28187325.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneALG5chr11:72794739chr13:37546173ENST00000443765498_28157295.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for FCHSD2-ALG5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>29979_29979_1_FCHSD2-ALG5_FCHSD2_chr11_72794739_ENST00000409314_ALG5_chr13_37546173_ENST00000239891_length(transcript)=860nt_BP=334nt
GTCCGCCTGCCGCCCGCTGGCCTGCTCCCTCCGGGGCAAGTCTTGCTTCTTAAGCGCTCCTTTCACACACGCGCGCGCTCGCTGGGCCGT
CCCCTCCTCTCCGGCCCTCCTCCTCCTCCTGGTCCTTGCTAACGCTGCCGTCGGGGAGGATTGATGTCCCTTCAGCATCATGCAGCCGCC
GCCGAGGAAGGTGAAAGTTACACAAGAACTGAAAAACATTCAAGTTGAGCAGATGACAAAACTTCAAGCCAAACATCAAGCAGAATGTGA
TTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAGTATGCACAGAATCAAATGGCTATAGCATGTGGATC
TCGAGCTCATTTAGAAAAAGAATCAATTGCTCAGCGTTCTTACTTCCGTACTCTTCTCATGTATGGGTTCCACTTTCTGGTGTGGTTCCT
TTGTGTCAAAGGAATCAGGGACACACAGTGTGGGTTCAAATTATTTACTCGAGAAGCAGCTTCACGGACGTTTTCATCTCTACACGTTGA
ACGATGGGCATTTGATGTAGAACTACTGTACATAGCACAGTTCTTTAAAATTCCAATAGCAGAAATTGCTGTCAACTGGACAGAAATTGA
AGGTTCTAAATTAGTTCCATTCTGGAGCTGGCTACAAATGGGTAAAGACCTACTTTTTATACGACTTCGATATTTGACTGGTGCCTGGAG
GCTTGAGCAAACTCGGAAAATGAATTAGGTTGTTTGCAGTCTTCAGTTGTGTTCTTATGCTTCAGTGTCACATTTCATTTCATTTGAAAC

>29979_29979_1_FCHSD2-ALG5_FCHSD2_chr11_72794739_ENST00000409314_ALG5_chr13_37546173_ENST00000239891_length(amino acids)=192AA_BP=54
MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQNQMAIACGSRAHLEKESIAQRSYFRTLLMYGFHFL
VWFLCVKGIRDTQCGFKLFTREAASRTFSSLHVERWAFDVELLYIAQFFKIPIAEIAVNWTEIEGSKLVPFWSWLQMGKDLLFIRLRYLT

--------------------------------------------------------------
>29979_29979_2_FCHSD2-ALG5_FCHSD2_chr11_72794739_ENST00000409314_ALG5_chr13_37546173_ENST00000413537_length(transcript)=801nt_BP=334nt
GTCCGCCTGCCGCCCGCTGGCCTGCTCCCTCCGGGGCAAGTCTTGCTTCTTAAGCGCTCCTTTCACACACGCGCGCGCTCGCTGGGCCGT
CCCCTCCTCTCCGGCCCTCCTCCTCCTCCTGGTCCTTGCTAACGCTGCCGTCGGGGAGGATTGATGTCCCTTCAGCATCATGCAGCCGCC
GCCGAGGAAGGTGAAAGTTACACAAGAACTGAAAAACATTCAAGTTGAGCAGATGACAAAACTTCAAGCCAAACATCAAGCAGAATGTGA
TTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAGTATGCACAGAATCAAATGGCTATAGCATGTGGATC
TCGAGCTCATTTAGAAAAAGAATCAATTGCTCAGCATAAGTGCTCTTTTGGAGGTTTAATCAGTCAACCAGTATTTATTGGAAGTATTTT
GTATGGAAGGCACTGAGCAAGCTGTTGTGAGATTCCTAAAGTATTTTAAGATGAGGTTTCTGCCCTATCTACTTAGAGAGCGTTCTTACT
TCCGTACTCTTCTCATGTATGGGTTCCACTTTCTGGTGTGGTTCCTTTGTGTCAAAGGAATCAGGGACACACAGTGTGGGTTCAAATTAT
TTACTCGAGAAGCAGCTTCACGGACGTTTTCATCTCTACACGTTGAACGATGGGCATTTGATGTAGAACTACTGTACATAGCACAGTTCT

>29979_29979_2_FCHSD2-ALG5_FCHSD2_chr11_72794739_ENST00000409314_ALG5_chr13_37546173_ENST00000413537_length(amino acids)=121AA_BP=
MEVFCMEGTEQAVVRFLKYFKMRFLPYLLRERSYFRTLLMYGFHFLVWFLCVKGIRDTQCGFKLFTREAASRTFSSLHVERWAFDVELLY

--------------------------------------------------------------
>29979_29979_3_FCHSD2-ALG5_FCHSD2_chr11_72794739_ENST00000409314_ALG5_chr13_37546173_ENST00000443765_length(transcript)=915nt_BP=334nt
GTCCGCCTGCCGCCCGCTGGCCTGCTCCCTCCGGGGCAAGTCTTGCTTCTTAAGCGCTCCTTTCACACACGCGCGCGCTCGCTGGGCCGT
CCCCTCCTCTCCGGCCCTCCTCCTCCTCCTGGTCCTTGCTAACGCTGCCGTCGGGGAGGATTGATGTCCCTTCAGCATCATGCAGCCGCC
GCCGAGGAAGGTGAAAGTTACACAAGAACTGAAAAACATTCAAGTTGAGCAGATGACAAAACTTCAAGCCAAACATCAAGCAGAATGTGA
TTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAGTATGCACAGAATCAAATGGCTATAGCATGTGGATC
TCGAGCTCATTTAGAAAAAGAATCAATTGCTCAGCGTTCTTACTTCCGTACTCTTCTCATGTATGGGTTCCACTTTCTGGTGTGGTTCCT
TTGTGTCAAAGGAATCAGGGACACACAGTGTGGGTTCAAATTATTTACTCGAGAAGCAGCTTCACGGACGTTTTCATCTCTACACGTTGA
ACGATGGGCATTTGATGTAGAACTACTGTACATAGCACAGTTCTTTAAAATTCCAATAGCAGAAATTGCTGTCAACTGGACAGAAATTGA
AGGTTCTAAATTAGTTCCATTCTGGAGCTGGCTACAAATGGGTAAAGACCTACTTTTTATACGACTTCGATATTTGACTGGTGCCTGGAG
GCTTGAGCAAACTCGGAAAATGAATTAGGTTGTTTGCAGTCTTCAGTTGTGTTCTTATGCTTCAGTGTCACATTTCATTTCATTTGAAAC
TAAAATTTTAAGTAAAGCTGAAATAAACTTCTTGTCATTGTCTGCCTTTTGATAATTTTAAAGAAATAACTTTCCATAAGTAAAAAATTA

>29979_29979_3_FCHSD2-ALG5_FCHSD2_chr11_72794739_ENST00000409314_ALG5_chr13_37546173_ENST00000443765_length(amino acids)=192AA_BP=54
MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQNQMAIACGSRAHLEKESIAQRSYFRTLLMYGFHFL
VWFLCVKGIRDTQCGFKLFTREAASRTFSSLHVERWAFDVELLYIAQFFKIPIAEIAVNWTEIEGSKLVPFWSWLQMGKDLLFIRLRYLT

--------------------------------------------------------------
>29979_29979_4_FCHSD2-ALG5_FCHSD2_chr11_72794739_ENST00000409418_ALG5_chr13_37546173_ENST00000239891_length(transcript)=1075nt_BP=549nt
GGCGGCGCAGGCGGCCGACCGGGAGCGCGGACAACGCGGCTGCGGCTAACCCGCCGCCCGGCCGGCTGAGACCCTCGCGCCCCTGCTCCT
GGGGCCCCCGCCCCCTCGCCGTCTCCGCCTCCTTCCTCACACACCCCCGGGCCGCCCGGGCCGCCCGGGCCCCAAGCCTTCCCGGTGCTC
CTCCCTCGTCTCCTCACACTCGCTCTCTGGCTGGGGTCCGCCTGCCGCCCGCTGGCCTGCTCCCTCCGGGGCAAGTCTTGCTTCTTAAGC
GCTCCTTTCACACACGCGCGCGCTCGCTGGGCCGTCCCCTCCTCTCCGGCCCTCCTCCTCCTCCTGGTCCTTGCTAACGCTGCCGTCGGG
GAGGATTGATGTCCCTTCAGCATCATGCAGCCGCCGCCGAGGAAGGTGAAAGTTACACAAGAACTGAAAAACATTCAAGTTGAGCAGATG
ACAAAACTTCAAGCCAAACATCAAGCAGAATGTGATTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAG
TATGCACAGAATCAAATGGCTATAGCATGTGGATCTCGAGCTCATTTAGAAAAAGAATCAATTGCTCAGCGTTCTTACTTCCGTACTCTT
CTCATGTATGGGTTCCACTTTCTGGTGTGGTTCCTTTGTGTCAAAGGAATCAGGGACACACAGTGTGGGTTCAAATTATTTACTCGAGAA
GCAGCTTCACGGACGTTTTCATCTCTACACGTTGAACGATGGGCATTTGATGTAGAACTACTGTACATAGCACAGTTCTTTAAAATTCCA
ATAGCAGAAATTGCTGTCAACTGGACAGAAATTGAAGGTTCTAAATTAGTTCCATTCTGGAGCTGGCTACAAATGGGTAAAGACCTACTT
TTTATACGACTTCGATATTTGACTGGTGCCTGGAGGCTTGAGCAAACTCGGAAAATGAATTAGGTTGTTTGCAGTCTTCAGTTGTGTTCT

>29979_29979_4_FCHSD2-ALG5_FCHSD2_chr11_72794739_ENST00000409418_ALG5_chr13_37546173_ENST00000239891_length(amino acids)=192AA_BP=54
MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQNQMAIACGSRAHLEKESIAQRSYFRTLLMYGFHFL
VWFLCVKGIRDTQCGFKLFTREAASRTFSSLHVERWAFDVELLYIAQFFKIPIAEIAVNWTEIEGSKLVPFWSWLQMGKDLLFIRLRYLT

--------------------------------------------------------------
>29979_29979_5_FCHSD2-ALG5_FCHSD2_chr11_72794739_ENST00000409418_ALG5_chr13_37546173_ENST00000413537_length(transcript)=1016nt_BP=549nt
GGCGGCGCAGGCGGCCGACCGGGAGCGCGGACAACGCGGCTGCGGCTAACCCGCCGCCCGGCCGGCTGAGACCCTCGCGCCCCTGCTCCT
GGGGCCCCCGCCCCCTCGCCGTCTCCGCCTCCTTCCTCACACACCCCCGGGCCGCCCGGGCCGCCCGGGCCCCAAGCCTTCCCGGTGCTC
CTCCCTCGTCTCCTCACACTCGCTCTCTGGCTGGGGTCCGCCTGCCGCCCGCTGGCCTGCTCCCTCCGGGGCAAGTCTTGCTTCTTAAGC
GCTCCTTTCACACACGCGCGCGCTCGCTGGGCCGTCCCCTCCTCTCCGGCCCTCCTCCTCCTCCTGGTCCTTGCTAACGCTGCCGTCGGG
GAGGATTGATGTCCCTTCAGCATCATGCAGCCGCCGCCGAGGAAGGTGAAAGTTACACAAGAACTGAAAAACATTCAAGTTGAGCAGATG
ACAAAACTTCAAGCCAAACATCAAGCAGAATGTGATTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAG
TATGCACAGAATCAAATGGCTATAGCATGTGGATCTCGAGCTCATTTAGAAAAAGAATCAATTGCTCAGCATAAGTGCTCTTTTGGAGGT
TTAATCAGTCAACCAGTATTTATTGGAAGTATTTTGTATGGAAGGCACTGAGCAAGCTGTTGTGAGATTCCTAAAGTATTTTAAGATGAG
GTTTCTGCCCTATCTACTTAGAGAGCGTTCTTACTTCCGTACTCTTCTCATGTATGGGTTCCACTTTCTGGTGTGGTTCCTTTGTGTCAA
AGGAATCAGGGACACACAGTGTGGGTTCAAATTATTTACTCGAGAAGCAGCTTCACGGACGTTTTCATCTCTACACGTTGAACGATGGGC
ATTTGATGTAGAACTACTGTACATAGCACAGTTCTTTAAAATTCCAATAGCAGAAATTGCTGTCAACTGGACAGAAATTGAAGGTTCTAA

>29979_29979_5_FCHSD2-ALG5_FCHSD2_chr11_72794739_ENST00000409418_ALG5_chr13_37546173_ENST00000413537_length(amino acids)=144AA_BP=
MFFSSCVTFTFLGGGCMMLKGHQSSPTAALARTRRRRRAGEEGTAQRARACVKGALKKQDLPRREQASGRQADPSQRASVRRRGRSTGKA

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>29979_29979_6_FCHSD2-ALG5_FCHSD2_chr11_72794739_ENST00000409418_ALG5_chr13_37546173_ENST00000443765_length(transcript)=1130nt_BP=549nt
GGCGGCGCAGGCGGCCGACCGGGAGCGCGGACAACGCGGCTGCGGCTAACCCGCCGCCCGGCCGGCTGAGACCCTCGCGCCCCTGCTCCT
GGGGCCCCCGCCCCCTCGCCGTCTCCGCCTCCTTCCTCACACACCCCCGGGCCGCCCGGGCCGCCCGGGCCCCAAGCCTTCCCGGTGCTC
CTCCCTCGTCTCCTCACACTCGCTCTCTGGCTGGGGTCCGCCTGCCGCCCGCTGGCCTGCTCCCTCCGGGGCAAGTCTTGCTTCTTAAGC
GCTCCTTTCACACACGCGCGCGCTCGCTGGGCCGTCCCCTCCTCTCCGGCCCTCCTCCTCCTCCTGGTCCTTGCTAACGCTGCCGTCGGG
GAGGATTGATGTCCCTTCAGCATCATGCAGCCGCCGCCGAGGAAGGTGAAAGTTACACAAGAACTGAAAAACATTCAAGTTGAGCAGATG
ACAAAACTTCAAGCCAAACATCAAGCAGAATGTGATTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAG
TATGCACAGAATCAAATGGCTATAGCATGTGGATCTCGAGCTCATTTAGAAAAAGAATCAATTGCTCAGCGTTCTTACTTCCGTACTCTT
CTCATGTATGGGTTCCACTTTCTGGTGTGGTTCCTTTGTGTCAAAGGAATCAGGGACACACAGTGTGGGTTCAAATTATTTACTCGAGAA
GCAGCTTCACGGACGTTTTCATCTCTACACGTTGAACGATGGGCATTTGATGTAGAACTACTGTACATAGCACAGTTCTTTAAAATTCCA
ATAGCAGAAATTGCTGTCAACTGGACAGAAATTGAAGGTTCTAAATTAGTTCCATTCTGGAGCTGGCTACAAATGGGTAAAGACCTACTT
TTTATACGACTTCGATATTTGACTGGTGCCTGGAGGCTTGAGCAAACTCGGAAAATGAATTAGGTTGTTTGCAGTCTTCAGTTGTGTTCT
TATGCTTCAGTGTCACATTTCATTTCATTTGAAACTAAAATTTTAAGTAAAGCTGAAATAAACTTCTTGTCATTGTCTGCCTTTTGATAA

>29979_29979_6_FCHSD2-ALG5_FCHSD2_chr11_72794739_ENST00000409418_ALG5_chr13_37546173_ENST00000443765_length(amino acids)=192AA_BP=54
MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQNQMAIACGSRAHLEKESIAQRSYFRTLLMYGFHFL
VWFLCVKGIRDTQCGFKLFTREAASRTFSSLHVERWAFDVELLYIAQFFKIPIAEIAVNWTEIEGSKLVPFWSWLQMGKDLLFIRLRYLT

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Fusion Gene PPI Analysis for FCHSD2-ALG5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FCHSD2-ALG5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FCHSD2-ALG5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFCHSD2C0087031Juvenile-Onset Still Disease1CTD_human
HgeneFCHSD2C3495559Juvenile arthritis1CTD_human
HgeneFCHSD2C3714758Juvenile psoriatic arthritis1CTD_human
HgeneFCHSD2C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneFCHSD2C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human