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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACYP2-YBX1 (FusionGDB2 ID:HG98TG4904)

Fusion Gene Summary for ACYP2-YBX1

check button Fusion gene summary
Fusion gene informationFusion gene name: ACYP2-YBX1
Fusion gene ID: hg98tg4904
HgeneTgene
Gene symbol

ACYP2

YBX1

Gene ID

98

4904

Gene nameacylphosphatase 2Y-box binding protein 1
SynonymsACYM|ACYPBP-8|CBF-A|CSDA2|CSDB|DBPB|EFI-A|MDR-NF1|NSEP-1|NSEP1|YB-1|YB1
Cytomap('ACYP2')('YBX1')

2p16.2

1p34.2

Type of geneprotein-codingprotein-coding
Descriptionacylphosphatase-2acylphosphatase 2, muscle typeacylphosphatase, muscle type isozymeacylphosphate phosphohydrolase 2testicular tissue protein Li 11Y-box-binding protein 1CCAAT-binding transcription factor I subunit ADNA-binding protein BY-box transcription factorenhancer factor I subunit Amajor histocompatibility complex, class II, Y box-binding protein Inuclease-sensitive element-binding prot
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000303536, ENST00000394666, 
ENST00000406041, ENST00000606865, 
ENST00000607452, ENST00000422521, 
ENST00000458030, ENST00000606082, 
Fusion gene scores* DoF score9 X 8 X 6=4328 X 7 X 6=336
# samples 98
** MAII scorelog2(9/432*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACYP2 [Title/Abstract] AND YBX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACYP2(54365885)-YBX1(43166451), # samples:1
Anticipated loss of major functional domain due to fusion event.ACYP2-YBX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACYP2-YBX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneYBX1

GO:0006355

regulation of transcription, DNA-templated

18809583

TgeneYBX1

GO:0045944

positive regulation of transcription by RNA polymerase II

18809583

TgeneYBX1

GO:0048255

mRNA stabilization

31358969

TgeneYBX1

GO:1990428

miRNA transport

27559612


check buttonFusion gene breakpoints across ACYP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across YBX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1847ACYP2chr2

54365885

+YBX1chr1

43166451

+


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Fusion Gene ORF analysis for ACYP2-YBX1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000303536ENST00000467957ACYP2chr2

54365885

+YBX1chr1

43166451

+
5CDS-intronENST00000394666ENST00000467957ACYP2chr2

54365885

+YBX1chr1

43166451

+
5CDS-intronENST00000406041ENST00000467957ACYP2chr2

54365885

+YBX1chr1

43166451

+
5CDS-intronENST00000606865ENST00000467957ACYP2chr2

54365885

+YBX1chr1

43166451

+
5CDS-intronENST00000607452ENST00000467957ACYP2chr2

54365885

+YBX1chr1

43166451

+
In-frameENST00000303536ENST00000321358ACYP2chr2

54365885

+YBX1chr1

43166451

+
In-frameENST00000394666ENST00000321358ACYP2chr2

54365885

+YBX1chr1

43166451

+
In-frameENST00000406041ENST00000321358ACYP2chr2

54365885

+YBX1chr1

43166451

+
In-frameENST00000606865ENST00000321358ACYP2chr2

54365885

+YBX1chr1

43166451

+
In-frameENST00000607452ENST00000321358ACYP2chr2

54365885

+YBX1chr1

43166451

+
intron-3CDSENST00000422521ENST00000321358ACYP2chr2

54365885

+YBX1chr1

43166451

+
intron-3CDSENST00000458030ENST00000321358ACYP2chr2

54365885

+YBX1chr1

43166451

+
intron-3CDSENST00000606082ENST00000321358ACYP2chr2

54365885

+YBX1chr1

43166451

+
intron-intronENST00000422521ENST00000467957ACYP2chr2

54365885

+YBX1chr1

43166451

+
intron-intronENST00000458030ENST00000467957ACYP2chr2

54365885

+YBX1chr1

43166451

+
intron-intronENST00000606082ENST00000467957ACYP2chr2

54365885

+YBX1chr1

43166451

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000607452ACYP2chr254365885+ENST00000321358YBX1chr143166451+1294659255893212
ENST00000303536ACYP2chr254365885+ENST00000321358YBX1chr143166451+1015380111614167
ENST00000394666ACYP2chr254365885+ENST00000321358YBX1chr143166451+1015380111614167
ENST00000606865ACYP2chr254365885+ENST00000321358YBX1chr143166451+977342112576154
ENST00000406041ACYP2chr254365885+ENST00000321358YBX1chr143166451+1116481212715167

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000607452ENST00000321358ACYP2chr254365885+YBX1chr143166451+0.0055674930.9944325
ENST00000303536ENST00000321358ACYP2chr254365885+YBX1chr143166451+0.0076006670.9923994
ENST00000394666ENST00000321358ACYP2chr254365885+YBX1chr143166451+0.0076006670.9923994
ENST00000606865ENST00000321358ACYP2chr254365885+YBX1chr143166451+0.0172392130.9827608
ENST00000406041ENST00000321358ACYP2chr254365885+YBX1chr143166451+0.0094907860.9905093

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Fusion Genomic Features for ACYP2-YBX1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACYP2chr254365885+YBX1chr143166451+1.89E-060.9999981
ACYP2chr254365885+YBX1chr143166451+1.89E-060.9999981

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ACYP2-YBX1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:54365885/chr1:43166451)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACYP2chr2:54365885chr1:43166451ENST00000394666+349_9961100.0DomainAcylphosphatase-like
TgeneYBX1chr2:54365885chr1:43166451ENST000003213585861_125246346.3333333333333DomainNote=CSD
TgeneYBX1chr2:54365885chr1:43166451ENST000003213585865_70246346.3333333333333RegionC5-methylcytosine binding


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Fusion Gene Sequence for ACYP2-YBX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1927_1927_1_ACYP2-YBX1_ACYP2_chr2_54365885_ENST00000303536_YBX1_chr1_43166451_ENST00000321358_length(transcript)=1015nt_BP=380nt
CGGCTGCCCTCGCTCCCAGGCCCCGCAGTCTCATTTGCCGCTTCCGACGCGTGACCCCGGCGCGCTAGCGTCCGGGACCGGTGACAGGCG
CGGGGTGCGCCAAGCAGTCCCATGTGTCCCCTCCCTCTCGCAGCCGCCGCAGTCGCTGCGCCCCGAGCCCCTCTCCGGCTCCTCAACAGA
GGGCTCGCCGCCGCCATGTCTACCGCCCAGTCACTCAAATCCGTGGACTACGAGGTGTTCGGAAGAGTGCAGGGTGTTTGCTTCAGAATG
TATACAGAAGATGAAGCTAGGAAAATAGGAGTGGTTGGCTGGGTGAAGAATACCAGCAAAGGCACCGTGACAGGCCAAGTGCAGGGGCCA
GAAGACAAAGTCAATTCCATGGGCCCTCCTCGCCAAAGACAGCCTAGAGAGGACGGCAATGAAGAAGATAAAGAAAATCAAGGAGATGAG
ACCCAAGGTCAGCAGCCACCTCAACGTCGGTACCGCCGCAACTTCAATTACCGACGCAGACGCCCAGAAAACCCTAAACCACAAGATGGC
AAAGAGACAAAAGCAGCCGATCCACCAGCTGAGAATTCGTCCGCTCCCGAGGCTGAGCAGGGCGGGGCTGAGTAAATGCCGGCTTACCAT
CTCTACCATCATCCGGTTTAGTCATCCAACAAGAAGAAATATGAAATTCCAGCAATAAGAAATGAACAAAAGATTGGAGCTGAAGACCTA
AAGTGCTTGCTTTTTGCCCGTTGACCAGATAAATAGAACTATCTGCATTATCTATGCAGCATGGGGTTTTTATTATTTTTACCTAAAGAC
GTCTCTTTTTGGTAATAACAAACGTGTTTTTTAAAAAAGCCTGGTTTTTCTCAATACGCCTTTAAAGGTTTTTAAATTGTTTCATATCTG
GTCAAGTTGAGATTTTTAAGAACTTCATTTTTAATTTGTAATAAAAGTTTACAACTTGATTTTTTCAAAAAAGTCAACAAACTGCAAGCA
CCTGTTAATAAAGGTCTTAAATAAT

>1927_1927_1_ACYP2-YBX1_ACYP2_chr2_54365885_ENST00000303536_YBX1_chr1_43166451_ENST00000321358_length(amino acids)=167AA_BP=90
MCPLPLAAAAVAAPRAPLRLLNRGLAAAMSTAQSLKSVDYEVFGRVQGVCFRMYTEDEARKIGVVGWVKNTSKGTVTGQVQGPEDKVNSM
GPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKETKAADPPAENSSAPEAEQGGAE

--------------------------------------------------------------
>1927_1927_2_ACYP2-YBX1_ACYP2_chr2_54365885_ENST00000394666_YBX1_chr1_43166451_ENST00000321358_length(transcript)=1015nt_BP=380nt
CGGCTGCCCTCGCTCCCAGGCCCCGCAGTCTCATTTGCCGCTTCCGACGCGTGACCCCGGCGCGCTAGCGTCCGGGACCGGTGACAGGCG
CGGGGTGCGCCAAGCAGTCCCATGTGTCCCCTCCCTCTCGCAGCCGCCGCAGTCGCTGCGCCCCGAGCCCCTCTCCGGCTCCTCAACAGA
GGGCTCGCCGCCGCCATGTCTACCGCCCAGTCACTCAAATCCGTGGACTACGAGGTGTTCGGAAGAGTGCAGGGTGTTTGCTTCAGAATG
TATACAGAAGATGAAGCTAGGAAAATAGGAGTGGTTGGCTGGGTGAAGAATACCAGCAAAGGCACCGTGACAGGCCAAGTGCAGGGGCCA
GAAGACAAAGTCAATTCCATGGGCCCTCCTCGCCAAAGACAGCCTAGAGAGGACGGCAATGAAGAAGATAAAGAAAATCAAGGAGATGAG
ACCCAAGGTCAGCAGCCACCTCAACGTCGGTACCGCCGCAACTTCAATTACCGACGCAGACGCCCAGAAAACCCTAAACCACAAGATGGC
AAAGAGACAAAAGCAGCCGATCCACCAGCTGAGAATTCGTCCGCTCCCGAGGCTGAGCAGGGCGGGGCTGAGTAAATGCCGGCTTACCAT
CTCTACCATCATCCGGTTTAGTCATCCAACAAGAAGAAATATGAAATTCCAGCAATAAGAAATGAACAAAAGATTGGAGCTGAAGACCTA
AAGTGCTTGCTTTTTGCCCGTTGACCAGATAAATAGAACTATCTGCATTATCTATGCAGCATGGGGTTTTTATTATTTTTACCTAAAGAC
GTCTCTTTTTGGTAATAACAAACGTGTTTTTTAAAAAAGCCTGGTTTTTCTCAATACGCCTTTAAAGGTTTTTAAATTGTTTCATATCTG
GTCAAGTTGAGATTTTTAAGAACTTCATTTTTAATTTGTAATAAAAGTTTACAACTTGATTTTTTCAAAAAAGTCAACAAACTGCAAGCA
CCTGTTAATAAAGGTCTTAAATAAT

>1927_1927_2_ACYP2-YBX1_ACYP2_chr2_54365885_ENST00000394666_YBX1_chr1_43166451_ENST00000321358_length(amino acids)=167AA_BP=90
MCPLPLAAAAVAAPRAPLRLLNRGLAAAMSTAQSLKSVDYEVFGRVQGVCFRMYTEDEARKIGVVGWVKNTSKGTVTGQVQGPEDKVNSM
GPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKETKAADPPAENSSAPEAEQGGAE

--------------------------------------------------------------
>1927_1927_3_ACYP2-YBX1_ACYP2_chr2_54365885_ENST00000406041_YBX1_chr1_43166451_ENST00000321358_length(transcript)=1116nt_BP=481nt
ATTAAATGGTAGGGAGCGCTGTGGAGACAGCATCCTCCCCAGTCCGGGAAGAGAGGCCTAGGATGCCTGGGGCCCAGCGGCCTCTTCCCT
CCTGGCGTCCCCGGCTGCCCTCGCTCCCAGGCCCCGCAGTCTCATTTGCCGCTTCCGACGCGTGACCCCGGCGCGCTAGCGTCCGGGACC
GGTGACAGGCGCGGGGTGCGCCAAGCAGTCCCATGTGTCCCCTCCCTCTCGCAGCCGCCGCAGTCGCTGCGCCCCGAGCCCCTCTCCGGC
TCCTCAACAGAGGGCTCGCCGCCGCCATGTCTACCGCCCAGTCACTCAAATCCGTGGACTACGAGGTGTTCGGAAGAGTGCAGGGTGTTT
GCTTCAGAATGTATACAGAAGATGAAGCTAGGAAAATAGGAGTGGTTGGCTGGGTGAAGAATACCAGCAAAGGCACCGTGACAGGCCAAG
TGCAGGGGCCAGAAGACAAAGTCAATTCCATGGGCCCTCCTCGCCAAAGACAGCCTAGAGAGGACGGCAATGAAGAAGATAAAGAAAATC
AAGGAGATGAGACCCAAGGTCAGCAGCCACCTCAACGTCGGTACCGCCGCAACTTCAATTACCGACGCAGACGCCCAGAAAACCCTAAAC
CACAAGATGGCAAAGAGACAAAAGCAGCCGATCCACCAGCTGAGAATTCGTCCGCTCCCGAGGCTGAGCAGGGCGGGGCTGAGTAAATGC
CGGCTTACCATCTCTACCATCATCCGGTTTAGTCATCCAACAAGAAGAAATATGAAATTCCAGCAATAAGAAATGAACAAAAGATTGGAG
CTGAAGACCTAAAGTGCTTGCTTTTTGCCCGTTGACCAGATAAATAGAACTATCTGCATTATCTATGCAGCATGGGGTTTTTATTATTTT
TACCTAAAGACGTCTCTTTTTGGTAATAACAAACGTGTTTTTTAAAAAAGCCTGGTTTTTCTCAATACGCCTTTAAAGGTTTTTAAATTG
TTTCATATCTGGTCAAGTTGAGATTTTTAAGAACTTCATTTTTAATTTGTAATAAAAGTTTACAACTTGATTTTTTCAAAAAAGTCAACA
AACTGCAAGCACCTGTTAATAAAGGTCTTAAATAAT

>1927_1927_3_ACYP2-YBX1_ACYP2_chr2_54365885_ENST00000406041_YBX1_chr1_43166451_ENST00000321358_length(amino acids)=167AA_BP=90
MCPLPLAAAAVAAPRAPLRLLNRGLAAAMSTAQSLKSVDYEVFGRVQGVCFRMYTEDEARKIGVVGWVKNTSKGTVTGQVQGPEDKVNSM
GPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKETKAADPPAENSSAPEAEQGGAE

--------------------------------------------------------------
>1927_1927_4_ACYP2-YBX1_ACYP2_chr2_54365885_ENST00000606865_YBX1_chr1_43166451_ENST00000321358_length(transcript)=977nt_BP=342nt
ACACACTAATGATACGCCTCCTCACAGAAGGAATTTCCGCTAGAGAGAAAGATGCTTTCTCCTGCAGAAATAAGTTATAAAATCTAGAGA
GAGCTCAGTCATTTAGTTCTACTTGCCGTACTTCAAGAGGATCTTCACTGCAGTTGTTTTGGTATGGAGTGATAGGAAAAAGTCAGGGAG
GTTGTACGGTAAGCAAAATTGGAGAATGACTGCCCTTGTTCTACAAATAGAGTATACAGAAGATGAAGCTAGGAAAATAGGAGTGGTTGG
CTGGGTGAAGAATACCAGCAAAGGCACCGTGACAGGCCAAGTGCAGGGGCCAGAAGACAAAGTCAATTCCATGGGCCCTCCTCGCCAAAG
ACAGCCTAGAGAGGACGGCAATGAAGAAGATAAAGAAAATCAAGGAGATGAGACCCAAGGTCAGCAGCCACCTCAACGTCGGTACCGCCG
CAACTTCAATTACCGACGCAGACGCCCAGAAAACCCTAAACCACAAGATGGCAAAGAGACAAAAGCAGCCGATCCACCAGCTGAGAATTC
GTCCGCTCCCGAGGCTGAGCAGGGCGGGGCTGAGTAAATGCCGGCTTACCATCTCTACCATCATCCGGTTTAGTCATCCAACAAGAAGAA
ATATGAAATTCCAGCAATAAGAAATGAACAAAAGATTGGAGCTGAAGACCTAAAGTGCTTGCTTTTTGCCCGTTGACCAGATAAATAGAA
CTATCTGCATTATCTATGCAGCATGGGGTTTTTATTATTTTTACCTAAAGACGTCTCTTTTTGGTAATAACAAACGTGTTTTTTAAAAAA
GCCTGGTTTTTCTCAATACGCCTTTAAAGGTTTTTAAATTGTTTCATATCTGGTCAAGTTGAGATTTTTAAGAACTTCATTTTTAATTTG
TAATAAAAGTTTACAACTTGATTTTTTCAAAAAAGTCAACAAACTGCAAGCACCTGTTAATAAAGGTCTTAAATAAT

>1927_1927_4_ACYP2-YBX1_ACYP2_chr2_54365885_ENST00000606865_YBX1_chr1_43166451_ENST00000321358_length(amino acids)=154AA_BP=77
MPYFKRIFTAVVLVWSDRKKSGRLYGKQNWRMTALVLQIEYTEDEARKIGVVGWVKNTSKGTVTGQVQGPEDKVNSMGPPRQRQPREDGN
EEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKETKAADPPAENSSAPEAEQGGAE

--------------------------------------------------------------
>1927_1927_5_ACYP2-YBX1_ACYP2_chr2_54365885_ENST00000607452_YBX1_chr1_43166451_ENST00000321358_length(transcript)=1294nt_BP=659nt
GGGAGGCGGTGGTGGCGGCAGCTGGAGCCCAACGGGCTGCGCCTTCTTCGCCGTGGGCCCGGCTCGGAGCCCCCACCCCAGGCCTCACCG
GCCCAGCGCGAGGCTGCCTCACCGGAAACACGAGGCCGAATTCCAAGCTATTGTCCTGCTTCGCCGGGGGTCGCGCACTCCAAGCGGCAG
CCCACTGGAGTCCCAGTCGCCACGACAGGCGGCAGCCAGACTCAGCCTGCCTGCACCCAGGTGAAATAAACAGCCATGTTGCTCACACAA
AGCCTGTTTGGTGGTCTCTTCCCACGGACGCGCGAGACAATGAGGAGATACAAGGTCTCGCTGTTCTACCTAGGCTGTTCTAGAACTCCT
AATGTCAAGCTATCCTCCTGCCTCGGCCTCCCATGCTGTTGGGATTACAGCTATAAATTCATACAATTATCAGAGTTTGGTTTTGGTCAA
GTCATAATTGTGAGTGAAGAACCATGGAAGGAGAACATTTCTTGCTCATCAACTACTTTCATAAAATCAACAATTTGCTTAAGTGTTTGC
TTCAGAATGTATACAGAAGATGAAGCTAGGAAAATAGGAGTGGTTGGCTGGGTGAAGAATACCAGCAAAGGCACCGTGACAGGCCAAGTG
CAGGGGCCAGAAGACAAAGTCAATTCCATGGGCCCTCCTCGCCAAAGACAGCCTAGAGAGGACGGCAATGAAGAAGATAAAGAAAATCAA
GGAGATGAGACCCAAGGTCAGCAGCCACCTCAACGTCGGTACCGCCGCAACTTCAATTACCGACGCAGACGCCCAGAAAACCCTAAACCA
CAAGATGGCAAAGAGACAAAAGCAGCCGATCCACCAGCTGAGAATTCGTCCGCTCCCGAGGCTGAGCAGGGCGGGGCTGAGTAAATGCCG
GCTTACCATCTCTACCATCATCCGGTTTAGTCATCCAACAAGAAGAAATATGAAATTCCAGCAATAAGAAATGAACAAAAGATTGGAGCT
GAAGACCTAAAGTGCTTGCTTTTTGCCCGTTGACCAGATAAATAGAACTATCTGCATTATCTATGCAGCATGGGGTTTTTATTATTTTTA
CCTAAAGACGTCTCTTTTTGGTAATAACAAACGTGTTTTTTAAAAAAGCCTGGTTTTTCTCAATACGCCTTTAAAGGTTTTTAAATTGTT
TCATATCTGGTCAAGTTGAGATTTTTAAGAACTTCATTTTTAATTTGTAATAAAAGTTTACAACTTGATTTTTTCAAAAAAGTCAACAAA
CTGCAAGCACCTGTTAATAAAGGTCTTAAATAAT

>1927_1927_5_ACYP2-YBX1_ACYP2_chr2_54365885_ENST00000607452_YBX1_chr1_43166451_ENST00000321358_length(amino acids)=212AA_BP=33
MLLTQSLFGGLFPRTRETMRRYKVSLFYLGCSRTPNVKLSSCLGLPCCWDYSYKFIQLSEFGFGQVIIVSEEPWKENISCSSTTFIKSTI
CLSVCFRMYTEDEARKIGVVGWVKNTSKGTVTGQVQGPEDKVNSMGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRP
ENPKPQDGKETKAADPPAENSSAPEAEQGGAE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ACYP2-YBX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneYBX1chr2:54365885chr1:43166451ENST000003213585815_71246.66666666666666346.3333333333333ss-DNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACYP2-YBX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACYP2-YBX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACYP2C2750088HEARING LOSS, CISPLATIN-INDUCED, SUSCEPTIBILITY TO1CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0007102Malignant tumor of colon1CTD_human
TgeneC0009375Colonic Neoplasms1CTD_human
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0027643Neoplasm Recurrence, Local1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human