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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP44-C17orf78 (FusionGDB2 ID:HG9912TG284099)

Fusion Gene Summary for ARHGAP44-C17orf78

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP44-C17orf78
Fusion gene ID: hg9912tg284099
HgeneTgene
Gene symbol

ARHGAP44

C17orf78

Gene ID

9912

284099

Gene nameRho GTPase activating protein 44chromosome 17 open reading frame 78
SynonymsNPC-A-10|RICH2-
Cytomap('ARHGAP44')('C17orf78')

17p12

17q12

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 44Rho-type GTPase-activating protein RICH2RhoGAP interacting with CIP4 homologs protein 2rho GTPase-activating protein RICH2uncharacterized protein C17orf78
Modification date2020031320200313
UniProtAcc.

Q8N4C9

Ensembl transtripts involved in fusion geneENST00000262444, ENST00000340825, 
ENST00000379672, ENST00000578087, 
Fusion gene scores* DoF score9 X 8 X 6=4324 X 6 X 5=120
# samples 95
** MAII scorelog2(9/432*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/120*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP44 [Title/Abstract] AND C17orf78 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP44(12862214)-C17orf78(35746181), # samples:1
ARHGAP44(12862214)-C17orf78(35736075), # samples:1
Anticipated loss of major functional domain due to fusion event.ARHGAP44-C17orf78 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP44-C17orf78 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP44-C17orf78 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP44-C17orf78 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP44-C17orf78 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARHGAP44 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across C17orf78 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-V1-A8ML-01AARHGAP44chr17

12862214

-C17orf78chr17

35736075

+
ChimerDB4PRADTCGA-V1-A8ML-01AARHGAP44chr17

12862214

+C17orf78chr17

35746181

+


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Fusion Gene ORF analysis for ARHGAP44-C17orf78

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000262444ENST00000300618ARHGAP44chr17

12862214

-C17orf78chr17

35736075

+
Frame-shiftENST00000262444ENST00000300618ARHGAP44chr17

12862214

+C17orf78chr17

35746181

+
Frame-shiftENST00000262444ENST00000586700ARHGAP44chr17

12862214

-C17orf78chr17

35736075

+
Frame-shiftENST00000340825ENST00000300618ARHGAP44chr17

12862214

-C17orf78chr17

35736075

+
Frame-shiftENST00000340825ENST00000300618ARHGAP44chr17

12862214

+C17orf78chr17

35746181

+
Frame-shiftENST00000340825ENST00000586700ARHGAP44chr17

12862214

-C17orf78chr17

35736075

+
Frame-shiftENST00000379672ENST00000300618ARHGAP44chr17

12862214

-C17orf78chr17

35736075

+
Frame-shiftENST00000379672ENST00000300618ARHGAP44chr17

12862214

+C17orf78chr17

35746181

+
Frame-shiftENST00000379672ENST00000586700ARHGAP44chr17

12862214

-C17orf78chr17

35736075

+
In-frameENST00000262444ENST00000586700ARHGAP44chr17

12862214

+C17orf78chr17

35746181

+
In-frameENST00000340825ENST00000586700ARHGAP44chr17

12862214

+C17orf78chr17

35746181

+
In-frameENST00000379672ENST00000586700ARHGAP44chr17

12862214

+C17orf78chr17

35746181

+
intron-3CDSENST00000578087ENST00000300618ARHGAP44chr17

12862214

-C17orf78chr17

35736075

+
intron-3CDSENST00000578087ENST00000300618ARHGAP44chr17

12862214

+C17orf78chr17

35746181

+
intron-3CDSENST00000578087ENST00000586700ARHGAP44chr17

12862214

-C17orf78chr17

35736075

+
intron-3CDSENST00000578087ENST00000586700ARHGAP44chr17

12862214

+C17orf78chr17

35746181

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000379672ARHGAP44chr1712862214+ENST00000586700C17orf78chr1735746181+300018233001835511
ENST00000340825ARHGAP44chr1712862214+ENST00000586700C17orf78chr1735746181+300018233001835511
ENST00000262444ARHGAP44chr1712862214+ENST00000586700C17orf78chr1735746181+27791602791614511

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379672ENST00000586700ARHGAP44chr1712862214+C17orf78chr1735746181+0.0033322870.9966677
ENST00000340825ENST00000586700ARHGAP44chr1712862214+C17orf78chr1735746181+0.0033322870.9966677
ENST00000262444ENST00000586700ARHGAP44chr1712862214+C17orf78chr1735746181+0.0029726360.99702734

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Fusion Genomic Features for ARHGAP44-C17orf78


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARHGAP44chr1712862214+C17orf78chr1735746180+1.74E-060.9999982
ARHGAP44chr1712862214+C17orf78chr1735746180+1.74E-060.9999982

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARHGAP44-C17orf78


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:12862214/chr17:35746181)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.C17orf78

Q8N4C9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP44chr17:12862214chr17:35746181ENST00000379672+162114_249507819.0DomainBAR
HgeneARHGAP44chr17:12862214chr17:35746181ENST00000379672+1621255_445507819.0DomainRho-GAP
TgeneC17orf78chr17:12862214chr17:35746181ENST0000058670025187_207130458.3333333333333TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP44chr17:12862214chr17:35746181ENST00000379672+1621815_818507819.0MotifPDZ-binding
TgeneC17orf78chr17:12862214chr17:35746181ENST0000030061847187_207211276.0TransmembraneHelical


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Fusion Gene Sequence for ARHGAP44-C17orf78


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6121_6121_1_ARHGAP44-C17orf78_ARHGAP44_chr17_12862214_ENST00000262444_C17orf78_chr17_35746181_ENST00000586700_length(transcript)=2779nt_BP=1602nt
GAGCCATGTAACCCTGCGGCGGGCTCCGGGCTGCTCCGTCCTTCCCCAGCTCCCGGGCTAGCGCGGCAGCGGGGCCACGATGAAGAAGCA
GTTCAATCGCATGCGCCAGCTGGCCAACCAGACGGTGGGCAGGGCTGAAAAGACAGAAGTTTTGAGTGAAGACCTTCTTCAGGTGGAGAA
GCGTCTGGAGCTGGTGAAACAGGTGTCCCACAGCACGCACAAGAAGCTCACCGCATGTCTGCAGGGCCAGCAAGGGGCAGAGGCTGACAA
GCGCTCCAAAAAGTTGCCTTTGACAACACTGGCTCAGTGTCTGATGGAGGGGTCAGCTATCCTGGGAGATGACACACTTCTTGGGAAGAT
GCTGAAACTCTGTGGAGAGACGGAGGACAAGCTGGCTCAGGAGCTGATACATTTTGAGTTGCAAGTAGAGAGAGACGTGATTGAGCCCCT
GTTTTTGCTGGCGGAGGTGGAAATCCCAAATATTCAAAAGCAGAGGAAACACTTAGCCAAGTTGGTGCTGGACATGGATTCCTCACGAAC
CAGGTGGCAGCAGACTTCCAAGTCTTCAGGTTTGTCCAGCAGCTTACAGCCTGCGGGTGCCAAGGCTGATGCCCTCAGGGAAGAAATGGA
AGAGGCTGCCAACAGAGTGGAGATTTGCAGGGACCAGCTCTCAGCTGATATGTACAGTTTTGTGGCCAAAGAAATTGACTATGCAAACTA
CTTTCAAACGCTAATAGAAGTGCAAGCTGAATACCACAGGAAGTCCCTGACACTATTGCAGGCTGTATTGCCTCAGATCAAAGCACAACA
GGAGGCCTGGGTAGAGAAGCCTTCCTTCGGGAAGCCGCTGGAGGAGCACCTCACCATCAGCGGCCGGGAGATCGCCTTCCCCATCGAGGC
GTGTGTGACCATGCTGCTTGAGTGTGGGATGCAGGAGGAGGGACTCTTCCGAGTAGCCCCCTCTGCCTCCAAACTGAAGAAGCTGAAAGC
GGCCCTGGACTGCTGCGTGGTGGATGTGCAGGAGTACTCGGCAGACCCCCACGCAATTGCAGGAGCTTTGAAATCTTACCTCCGAGAGTT
GCCAGAACCTCTTATGACCTTTGAACTCTATGATGAGTGGATCCAGGCTTCCAATGTCCAGGAGCAAGACAAGAAGCTTCAGGCTCTATG
GAATGCTTGTGAAAAGTTGCCCAAGGCCAATCACAACAACATCCGATACTTGATAAAATTTTTATCCAAGCTGTCAGAATATCAAGATGT
AAACAAGATGACTCCCAGTAATATGGCAATTGTTTTAGGACCCAACCTCCTATGGCCACAAGCAGAAGGGAACATTACAGAGATGATGAC
CACAGTGTCGCTGCAAATTGTTGGGATCATTGAACCTATCATCCAGCATGCAGACTGGTTCTTCCCTGGGGAGATAGAGTTCAACATTAC
TGGCAATTATGGGAGTCCAGTACACGTGAACCATAATGCCAACTACAGCTCAATGCCCTCCCCAGACATGGACCCTGCTGACCGGCGCCA
GCCCGAGCAGGCCCGCCGGCCCCTCAGCGTCGCCACGGATAATATGATGCTGGAGTTTTACAAAAAGGATGGTATCAATGCCTAGGAGCC
AGGAAGCTGTGCCAATGCCAGTGGTTGTGGAGATGGCAAAAGAAGGGAGGCCAGCCACCTGGGACAGCTGAATCCAAGCCTGACTCTCAG
CCCCAGAAGGTTGGACAAGATGCTGCCAATTCATCAAACCCAAAGAAAGCTGCAGAGATCACTGTTATCCACCAGACATACTTCTGAAAA
GTTCTGCTCTATCTCAAAGACTGAATGATACTACACAGTCCTCTCCCTATTAATATGGGCACATTCTTGCCAATTTCACACTTGTATCTT
CAGCAGGGACATTACAATCAAACACCAATTCCTGGTTAATGAAGGGAGAGTGTGGGCTTAGCAGAGTTACCCTCATGCCCCTATCTGAGC
CACAACCTTCTGTAATTCACTTCATACATCCATCTAAATGGATACCTTTCCATCCCCTCAAACGAGAACAAAAAGTATTCCCTGCAAGCA
CTATGAATGGACCTTACTACTCTCTTTGACAGAAGACTCAAACACAGCCTCTAAGAAACAAGGCAGCTGTTAGTGTGACATAGCTTCCAG
CTCCTCTGTTATCTTCACAGCTGACTTCACACTCACTGGCCCTCAATAGCTTAGAGTGGGACTCCTGATCTCCCTGGTTGACGTTTATAA
GGTTTTGTAATTTAGCTTCTGGTACTACATGTATCTATCCACACACTGCTGAAGGGAACTTGACCCTACGCATTCCAAAAGCCTTCCTCA
TAAGTTATCCCCAAGGGGTTCAGGGACTACAGACCATTAGTACCCAAGTGAAGTCTTCTGACGATCCAGAATTCCTAAGGTGGCTCTGAT
ATTATATCATACTTTAATAGAGAGTTGCATACCTTTTGGACAAAGATTCCAGAGCAAAATAATTATGATAATGCTGTTTCTCACAGGAGA
ATAGCTATGAGTCAAATCTAACCTGCTTAAATAAGAGTTTGGTGAGAAAGTGAAACCACCTGATCTTGAATCAATGTTGAGGTGAAAAAG
GAAATGTCAGGAGGGATAAGACAGGGTGAGGCCCTGCTTCTTTTCCTAAGAGTCTGAAACCATTCCATTTCATTTTGGTGAAATGTGTCT

>6121_6121_1_ARHGAP44-C17orf78_ARHGAP44_chr17_12862214_ENST00000262444_C17orf78_chr17_35746181_ENST00000586700_length(amino acids)=511AA_BP=
MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTL
LGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR
EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPSFGKPLEEHLTISGREIAF
PIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKL
QALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIE

--------------------------------------------------------------
>6121_6121_2_ARHGAP44-C17orf78_ARHGAP44_chr17_12862214_ENST00000340825_C17orf78_chr17_35746181_ENST00000586700_length(transcript)=3000nt_BP=1823nt
GACTGGGAGCAGGCAGCCCGGGCGGAGCGGGCCGGTGCCGAGGACGGCCCCAGGCATTGCTCTGCCCCGGGCATTGCGCGGCGCGCGTGA
GGGGGATGCGGCAGGAGGCGGCGCGGCGGGAGGAGTAGGCGGCGGCGCCCTCGGGAGGGAGCTGCGCGCGGGCCAGACGGCGCCCGGAGG
CTCCGCAGTGCCGCCGCCGTCGCCCGGGAGGCTCCGCGCGGGAGCCATGTAACCCTGCGGCGGGCTCCGGGCTGCTCCGTCCTTCCCCAG
CTCCCGGGCTAGCGCGGCAGCGGGGCCACGATGAAGAAGCAGTTCAATCGCATGCGCCAGCTGGCCAACCAGACGGTGGGCAGGGCTGAA
AAGACAGAAGTTTTGAGTGAAGACCTTCTTCAGGTGGAGAAGCGTCTGGAGCTGGTGAAACAGGTGTCCCACAGCACGCACAAGAAGCTC
ACCGCATGTCTGCAGGGCCAGCAAGGGGCAGAGGCTGACAAGCGCTCCAAAAAGTTGCCTTTGACAACACTGGCTCAGTGTCTGATGGAG
GGGTCAGCTATCCTGGGAGATGACACACTTCTTGGGAAGATGCTGAAACTCTGTGGAGAGACGGAGGACAAGCTGGCTCAGGAGCTGATA
CATTTTGAGTTGCAAGTAGAGAGAGACGTGATTGAGCCCCTGTTTTTGCTGGCGGAGGTGGAAATCCCAAATATTCAAAAGCAGAGGAAA
CACTTAGCCAAGTTGGTGCTGGACATGGATTCCTCACGAACCAGGTGGCAGCAGACTTCCAAGTCTTCAGGTTTGTCCAGCAGCTTACAG
CCTGCGGGTGCCAAGGCTGATGCCCTCAGGGAAGAAATGGAAGAGGCTGCCAACAGAGTGGAGATTTGCAGGGACCAGCTCTCAGCTGAT
ATGTACAGTTTTGTGGCCAAAGAAATTGACTATGCAAACTACTTTCAAACGCTAATAGAAGTGCAAGCTGAATACCACAGGAAGTCCCTG
ACACTATTGCAGGCTGTATTGCCTCAGATCAAAGCACAACAGGAGGCCTGGGTAGAGAAGCCTTCCTTCGGGAAGCCGCTGGAGGAGCAC
CTCACCATCAGCGGCCGGGAGATCGCCTTCCCCATCGAGGCGTGTGTGACCATGCTGCTTGAGTGTGGGATGCAGGAGGAGGGACTCTTC
CGAGTAGCCCCCTCTGCCTCCAAACTGAAGAAGCTGAAAGCGGCCCTGGACTGCTGCGTGGTGGATGTGCAGGAGTACTCGGCAGACCCC
CACGCAATTGCAGGAGCTTTGAAATCTTACCTCCGAGAGTTGCCAGAACCTCTTATGACCTTTGAACTCTATGATGAGTGGATCCAGGCT
TCCAATGTCCAGGAGCAAGACAAGAAGCTTCAGGCTCTATGGAATGCTTGTGAAAAGTTGCCCAAGGCCAATCACAACAACATCCGATAC
TTGATAAAATTTTTATCCAAGCTGTCAGAATATCAAGATGTAAACAAGATGACTCCCAGTAATATGGCAATTGTTTTAGGACCCAACCTC
CTATGGCCACAAGCAGAAGGGAACATTACAGAGATGATGACCACAGTGTCGCTGCAAATTGTTGGGATCATTGAACCTATCATCCAGCAT
GCAGACTGGTTCTTCCCTGGGGAGATAGAGTTCAACATTACTGGCAATTATGGGAGTCCAGTACACGTGAACCATAATGCCAACTACAGC
TCAATGCCCTCCCCAGACATGGACCCTGCTGACCGGCGCCAGCCCGAGCAGGCCCGCCGGCCCCTCAGCGTCGCCACGGATAATATGATG
CTGGAGTTTTACAAAAAGGATGGTATCAATGCCTAGGAGCCAGGAAGCTGTGCCAATGCCAGTGGTTGTGGAGATGGCAAAAGAAGGGAG
GCCAGCCACCTGGGACAGCTGAATCCAAGCCTGACTCTCAGCCCCAGAAGGTTGGACAAGATGCTGCCAATTCATCAAACCCAAAGAAAG
CTGCAGAGATCACTGTTATCCACCAGACATACTTCTGAAAAGTTCTGCTCTATCTCAAAGACTGAATGATACTACACAGTCCTCTCCCTA
TTAATATGGGCACATTCTTGCCAATTTCACACTTGTATCTTCAGCAGGGACATTACAATCAAACACCAATTCCTGGTTAATGAAGGGAGA
GTGTGGGCTTAGCAGAGTTACCCTCATGCCCCTATCTGAGCCACAACCTTCTGTAATTCACTTCATACATCCATCTAAATGGATACCTTT
CCATCCCCTCAAACGAGAACAAAAAGTATTCCCTGCAAGCACTATGAATGGACCTTACTACTCTCTTTGACAGAAGACTCAAACACAGCC
TCTAAGAAACAAGGCAGCTGTTAGTGTGACATAGCTTCCAGCTCCTCTGTTATCTTCACAGCTGACTTCACACTCACTGGCCCTCAATAG
CTTAGAGTGGGACTCCTGATCTCCCTGGTTGACGTTTATAAGGTTTTGTAATTTAGCTTCTGGTACTACATGTATCTATCCACACACTGC
TGAAGGGAACTTGACCCTACGCATTCCAAAAGCCTTCCTCATAAGTTATCCCCAAGGGGTTCAGGGACTACAGACCATTAGTACCCAAGT
GAAGTCTTCTGACGATCCAGAATTCCTAAGGTGGCTCTGATATTATATCATACTTTAATAGAGAGTTGCATACCTTTTGGACAAAGATTC
CAGAGCAAAATAATTATGATAATGCTGTTTCTCACAGGAGAATAGCTATGAGTCAAATCTAACCTGCTTAAATAAGAGTTTGGTGAGAAA
GTGAAACCACCTGATCTTGAATCAATGTTGAGGTGAAAAAGGAAATGTCAGGAGGGATAAGACAGGGTGAGGCCCTGCTTCTTTTCCTAA
GAGTCTGAAACCATTCCATTTCATTTTGGTGAAATGTGTCTGTTTCTAAGAAATTCTGTTTTCTTAGTTCTCTGGTTAAAAAAAAAAATA

>6121_6121_2_ARHGAP44-C17orf78_ARHGAP44_chr17_12862214_ENST00000340825_C17orf78_chr17_35746181_ENST00000586700_length(amino acids)=511AA_BP=
MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTL
LGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR
EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPSFGKPLEEHLTISGREIAF
PIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKL
QALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIE

--------------------------------------------------------------
>6121_6121_3_ARHGAP44-C17orf78_ARHGAP44_chr17_12862214_ENST00000379672_C17orf78_chr17_35746181_ENST00000586700_length(transcript)=3000nt_BP=1823nt
GACTGGGAGCAGGCAGCCCGGGCGGAGCGGGCCGGTGCCGAGGACGGCCCCAGGCATTGCTCTGCCCCGGGCATTGCGCGGCGCGCGTGA
GGGGGATGCGGCAGGAGGCGGCGCGGCGGGAGGAGTAGGCGGCGGCGCCCTCGGGAGGGAGCTGCGCGCGGGCCAGACGGCGCCCGGAGG
CTCCGCAGTGCCGCCGCCGTCGCCCGGGAGGCTCCGCGCGGGAGCCATGTAACCCTGCGGCGGGCTCCGGGCTGCTCCGTCCTTCCCCAG
CTCCCGGGCTAGCGCGGCAGCGGGGCCACGATGAAGAAGCAGTTCAATCGCATGCGCCAGCTGGCCAACCAGACGGTGGGCAGGGCTGAA
AAGACAGAAGTTTTGAGTGAAGACCTTCTTCAGGTGGAGAAGCGTCTGGAGCTGGTGAAACAGGTGTCCCACAGCACGCACAAGAAGCTC
ACCGCATGTCTGCAGGGCCAGCAAGGGGCAGAGGCTGACAAGCGCTCCAAAAAGTTGCCTTTGACAACACTGGCTCAGTGTCTGATGGAG
GGGTCAGCTATCCTGGGAGATGACACACTTCTTGGGAAGATGCTGAAACTCTGTGGAGAGACGGAGGACAAGCTGGCTCAGGAGCTGATA
CATTTTGAGTTGCAAGTAGAGAGAGACGTGATTGAGCCCCTGTTTTTGCTGGCGGAGGTGGAAATCCCAAATATTCAAAAGCAGAGGAAA
CACTTAGCCAAGTTGGTGCTGGACATGGATTCCTCACGAACCAGGTGGCAGCAGACTTCCAAGTCTTCAGGTTTGTCCAGCAGCTTACAG
CCTGCGGGTGCCAAGGCTGATGCCCTCAGGGAAGAAATGGAAGAGGCTGCCAACAGAGTGGAGATTTGCAGGGACCAGCTCTCAGCTGAT
ATGTACAGTTTTGTGGCCAAAGAAATTGACTATGCAAACTACTTTCAAACGCTAATAGAAGTGCAAGCTGAATACCACAGGAAGTCCCTG
ACACTATTGCAGGCTGTATTGCCTCAGATCAAAGCACAACAGGAGGCCTGGGTAGAGAAGCCTTCCTTCGGGAAGCCGCTGGAGGAGCAC
CTCACCATCAGCGGCCGGGAGATCGCCTTCCCCATCGAGGCGTGTGTGACCATGCTGCTTGAGTGTGGGATGCAGGAGGAGGGACTCTTC
CGAGTAGCCCCCTCTGCCTCCAAACTGAAGAAGCTGAAAGCGGCCCTGGACTGCTGCGTGGTGGATGTGCAGGAGTACTCGGCAGACCCC
CACGCAATTGCAGGAGCTTTGAAATCTTACCTCCGAGAGTTGCCAGAACCTCTTATGACCTTTGAACTCTATGATGAGTGGATCCAGGCT
TCCAATGTCCAGGAGCAAGACAAGAAGCTTCAGGCTCTATGGAATGCTTGTGAAAAGTTGCCCAAGGCCAATCACAACAACATCCGATAC
TTGATAAAATTTTTATCCAAGCTGTCAGAATATCAAGATGTAAACAAGATGACTCCCAGTAATATGGCAATTGTTTTAGGACCCAACCTC
CTATGGCCACAAGCAGAAGGGAACATTACAGAGATGATGACCACAGTGTCGCTGCAAATTGTTGGGATCATTGAACCTATCATCCAGCAT
GCAGACTGGTTCTTCCCTGGGGAGATAGAGTTCAACATTACTGGCAATTATGGGAGTCCAGTACACGTGAACCATAATGCCAACTACAGC
TCAATGCCCTCCCCAGACATGGACCCTGCTGACCGGCGCCAGCCCGAGCAGGCCCGCCGGCCCCTCAGCGTCGCCACGGATAATATGATG
CTGGAGTTTTACAAAAAGGATGGTATCAATGCCTAGGAGCCAGGAAGCTGTGCCAATGCCAGTGGTTGTGGAGATGGCAAAAGAAGGGAG
GCCAGCCACCTGGGACAGCTGAATCCAAGCCTGACTCTCAGCCCCAGAAGGTTGGACAAGATGCTGCCAATTCATCAAACCCAAAGAAAG
CTGCAGAGATCACTGTTATCCACCAGACATACTTCTGAAAAGTTCTGCTCTATCTCAAAGACTGAATGATACTACACAGTCCTCTCCCTA
TTAATATGGGCACATTCTTGCCAATTTCACACTTGTATCTTCAGCAGGGACATTACAATCAAACACCAATTCCTGGTTAATGAAGGGAGA
GTGTGGGCTTAGCAGAGTTACCCTCATGCCCCTATCTGAGCCACAACCTTCTGTAATTCACTTCATACATCCATCTAAATGGATACCTTT
CCATCCCCTCAAACGAGAACAAAAAGTATTCCCTGCAAGCACTATGAATGGACCTTACTACTCTCTTTGACAGAAGACTCAAACACAGCC
TCTAAGAAACAAGGCAGCTGTTAGTGTGACATAGCTTCCAGCTCCTCTGTTATCTTCACAGCTGACTTCACACTCACTGGCCCTCAATAG
CTTAGAGTGGGACTCCTGATCTCCCTGGTTGACGTTTATAAGGTTTTGTAATTTAGCTTCTGGTACTACATGTATCTATCCACACACTGC
TGAAGGGAACTTGACCCTACGCATTCCAAAAGCCTTCCTCATAAGTTATCCCCAAGGGGTTCAGGGACTACAGACCATTAGTACCCAAGT
GAAGTCTTCTGACGATCCAGAATTCCTAAGGTGGCTCTGATATTATATCATACTTTAATAGAGAGTTGCATACCTTTTGGACAAAGATTC
CAGAGCAAAATAATTATGATAATGCTGTTTCTCACAGGAGAATAGCTATGAGTCAAATCTAACCTGCTTAAATAAGAGTTTGGTGAGAAA
GTGAAACCACCTGATCTTGAATCAATGTTGAGGTGAAAAAGGAAATGTCAGGAGGGATAAGACAGGGTGAGGCCCTGCTTCTTTTCCTAA
GAGTCTGAAACCATTCCATTTCATTTTGGTGAAATGTGTCTGTTTCTAAGAAATTCTGTTTTCTTAGTTCTCTGGTTAAAAAAAAAAATA

>6121_6121_3_ARHGAP44-C17orf78_ARHGAP44_chr17_12862214_ENST00000379672_C17orf78_chr17_35746181_ENST00000586700_length(amino acids)=511AA_BP=
MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTL
LGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR
EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPSFGKPLEEHLTISGREIAF
PIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKL
QALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIE

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Fusion Gene PPI Analysis for ARHGAP44-C17orf78


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneARHGAP44chr17:12862214chr17:35746181ENST00000379672+1621731_818507.6666666666667819.0BST2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP44-C17orf78


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGAP44-C17orf78


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource