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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDC20-DEF8 (FusionGDB2 ID:HG991TG54849)

Fusion Gene Summary for CDC20-DEF8

check button Fusion gene summary
Fusion gene informationFusion gene name: CDC20-DEF8
Fusion gene ID: hg991tg54849
HgeneTgene
Gene symbol

CDC20

DEF8

Gene ID

991

54849

Gene namecell division cycle 20differentially expressed in FDCP 8 homolog
SynonymsCDC20A|bA276H19.3|p55CDC-
Cytomap('CDC20')('DEF8')

1p34.2

16q24.3

Type of geneprotein-codingprotein-coding
Descriptioncell division cycle protein 20 homologCDC20 cell division cycle 20 homologcell division cycle 20 homologdifferentially expressed in FDCP 8 homologDEF-8
Modification date2020031320200313
UniProtAcc

Q12834

Q6ZN54

Ensembl transtripts involved in fusion geneENST00000478882, ENST00000310955, 
ENST00000372462, 
Fusion gene scores* DoF score4 X 5 X 3=601 X 2 X 1=2
# samples 41
** MAII scorelog2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/2*10)=2.32192809488736
Context

PubMed: CDC20 [Title/Abstract] AND DEF8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDC20(43825454)-DEF8(90025552), # samples:1
CDC20(43825453)-DEF8(90025551), # samples:1
Anticipated loss of major functional domain due to fusion event.CDC20-DEF8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDC20-DEF8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDC20-DEF8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDC20

GO:0031145

anaphase-promoting complex-dependent catabolic process

17443180

HgeneCDC20

GO:1904668

positive regulation of ubiquitin protein ligase activity

11459826


check buttonFusion gene breakpoints across CDC20 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DEF8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-4255-01ACDC20chr1

43825453

+DEF8chr16

90025551

+
ChimerDB4STADTCGA-BR-4255-01ACDC20chr1

43825454

+DEF8chr16

90025552

+


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Fusion Gene ORF analysis for CDC20-DEF8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000478882ENST00000268676CDC20chr1

43825453

+DEF8chr16

90025551

+
3UTR-3CDSENST00000478882ENST00000268676CDC20chr1

43825454

+DEF8chr16

90025552

+
3UTR-3CDSENST00000478882ENST00000418391CDC20chr1

43825453

+DEF8chr16

90025551

+
3UTR-3CDSENST00000478882ENST00000418391CDC20chr1

43825454

+DEF8chr16

90025552

+
3UTR-3CDSENST00000478882ENST00000563594CDC20chr1

43825453

+DEF8chr16

90025551

+
3UTR-3CDSENST00000478882ENST00000563594CDC20chr1

43825454

+DEF8chr16

90025552

+
3UTR-3CDSENST00000478882ENST00000563795CDC20chr1

43825453

+DEF8chr16

90025551

+
3UTR-3CDSENST00000478882ENST00000563795CDC20chr1

43825454

+DEF8chr16

90025552

+
3UTR-3CDSENST00000478882ENST00000567874CDC20chr1

43825453

+DEF8chr16

90025551

+
3UTR-3CDSENST00000478882ENST00000567874CDC20chr1

43825454

+DEF8chr16

90025552

+
3UTR-3CDSENST00000478882ENST00000569453CDC20chr1

43825453

+DEF8chr16

90025551

+
3UTR-3CDSENST00000478882ENST00000569453CDC20chr1

43825454

+DEF8chr16

90025552

+
3UTR-3CDSENST00000478882ENST00000570182CDC20chr1

43825453

+DEF8chr16

90025551

+
3UTR-3CDSENST00000478882ENST00000570182CDC20chr1

43825454

+DEF8chr16

90025552

+
3UTR-3UTRENST00000478882ENST00000563848CDC20chr1

43825453

+DEF8chr16

90025551

+
3UTR-3UTRENST00000478882ENST00000563848CDC20chr1

43825454

+DEF8chr16

90025552

+
5CDS-3UTRENST00000310955ENST00000563848CDC20chr1

43825453

+DEF8chr16

90025551

+
5CDS-3UTRENST00000310955ENST00000563848CDC20chr1

43825454

+DEF8chr16

90025552

+
5CDS-3UTRENST00000372462ENST00000563848CDC20chr1

43825453

+DEF8chr16

90025551

+
5CDS-3UTRENST00000372462ENST00000563848CDC20chr1

43825454

+DEF8chr16

90025552

+
Frame-shiftENST00000310955ENST00000268676CDC20chr1

43825453

+DEF8chr16

90025551

+
Frame-shiftENST00000310955ENST00000268676CDC20chr1

43825454

+DEF8chr16

90025552

+
Frame-shiftENST00000310955ENST00000563594CDC20chr1

43825453

+DEF8chr16

90025551

+
Frame-shiftENST00000310955ENST00000563594CDC20chr1

43825454

+DEF8chr16

90025552

+
Frame-shiftENST00000310955ENST00000563795CDC20chr1

43825453

+DEF8chr16

90025551

+
Frame-shiftENST00000310955ENST00000563795CDC20chr1

43825454

+DEF8chr16

90025552

+
Frame-shiftENST00000310955ENST00000567874CDC20chr1

43825453

+DEF8chr16

90025551

+
Frame-shiftENST00000310955ENST00000567874CDC20chr1

43825454

+DEF8chr16

90025552

+
Frame-shiftENST00000310955ENST00000569453CDC20chr1

43825453

+DEF8chr16

90025551

+
Frame-shiftENST00000310955ENST00000569453CDC20chr1

43825454

+DEF8chr16

90025552

+
Frame-shiftENST00000310955ENST00000570182CDC20chr1

43825453

+DEF8chr16

90025551

+
Frame-shiftENST00000310955ENST00000570182CDC20chr1

43825454

+DEF8chr16

90025552

+
Frame-shiftENST00000372462ENST00000268676CDC20chr1

43825453

+DEF8chr16

90025551

+
Frame-shiftENST00000372462ENST00000268676CDC20chr1

43825454

+DEF8chr16

90025552

+
Frame-shiftENST00000372462ENST00000563594CDC20chr1

43825453

+DEF8chr16

90025551

+
Frame-shiftENST00000372462ENST00000563594CDC20chr1

43825454

+DEF8chr16

90025552

+
Frame-shiftENST00000372462ENST00000563795CDC20chr1

43825453

+DEF8chr16

90025551

+
Frame-shiftENST00000372462ENST00000563795CDC20chr1

43825454

+DEF8chr16

90025552

+
Frame-shiftENST00000372462ENST00000567874CDC20chr1

43825453

+DEF8chr16

90025551

+
Frame-shiftENST00000372462ENST00000567874CDC20chr1

43825454

+DEF8chr16

90025552

+
Frame-shiftENST00000372462ENST00000569453CDC20chr1

43825453

+DEF8chr16

90025551

+
Frame-shiftENST00000372462ENST00000569453CDC20chr1

43825454

+DEF8chr16

90025552

+
Frame-shiftENST00000372462ENST00000570182CDC20chr1

43825453

+DEF8chr16

90025551

+
Frame-shiftENST00000372462ENST00000570182CDC20chr1

43825454

+DEF8chr16

90025552

+
In-frameENST00000310955ENST00000418391CDC20chr1

43825453

+DEF8chr16

90025551

+
In-frameENST00000310955ENST00000418391CDC20chr1

43825454

+DEF8chr16

90025552

+
In-frameENST00000372462ENST00000418391CDC20chr1

43825453

+DEF8chr16

90025551

+
In-frameENST00000372462ENST00000418391CDC20chr1

43825454

+DEF8chr16

90025552

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000310955CDC20chr143825454+ENST00000418391DEF8chr1690025552+691469101559152
ENST00000372462CDC20chr143825454+ENST00000418391DEF8chr1690025552+793571203661152
ENST00000310955CDC20chr143825453+ENST00000418391DEF8chr1690025551+693470101508135
ENST00000372462CDC20chr143825453+ENST00000418391DEF8chr1690025551+79557263488141

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000310955ENST00000418391CDC20chr143825454+DEF8chr1690025552+0.338209570.66179043
ENST00000372462ENST00000418391CDC20chr143825454+DEF8chr1690025552+0.39093860.6090614
ENST00000310955ENST00000418391CDC20chr143825453+DEF8chr1690025551+0.0710541460.9289459
ENST00000372462ENST00000418391CDC20chr143825453+DEF8chr1690025551+0.075989930.9240101

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Fusion Genomic Features for CDC20-DEF8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CDC20-DEF8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:43825454/chr16:90025552)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDC20

Q12834

DEF8

Q6ZN54

FUNCTION: Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. {ECO:0000269|PubMed:9637688, ECO:0000269|PubMed:9734353, ECO:0000269|PubMed:9811605}.FUNCTION: Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. {ECO:0000250|UniProtKB:Q99J78}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDEF8chr1:43825453chr16:90025551ENST00000268676013199_2500513.0Zinc fingerPhorbol-ester/DAG-type 1
TgeneDEF8chr1:43825453chr16:90025551ENST00000268676013429_4890513.0Zinc fingerPhorbol-ester/DAG-type 2
TgeneDEF8chr1:43825453chr16:90025551ENST0000041839106199_2500198.0Zinc fingerPhorbol-ester/DAG-type 1
TgeneDEF8chr1:43825453chr16:90025551ENST0000041839106429_4890198.0Zinc fingerPhorbol-ester/DAG-type 2
TgeneDEF8chr1:43825453chr16:90025551ENST00000563594013199_2500452.0Zinc fingerPhorbol-ester/DAG-type 1
TgeneDEF8chr1:43825453chr16:90025551ENST00000563594013429_4890452.0Zinc fingerPhorbol-ester/DAG-type 2
TgeneDEF8chr1:43825453chr16:90025551ENST00000563795013199_2500435.0Zinc fingerPhorbol-ester/DAG-type 1
TgeneDEF8chr1:43825453chr16:90025551ENST00000563795013429_4890435.0Zinc fingerPhorbol-ester/DAG-type 2
TgeneDEF8chr1:43825453chr16:90025551ENST00000567874012199_2500392.0Zinc fingerPhorbol-ester/DAG-type 1
TgeneDEF8chr1:43825453chr16:90025551ENST00000567874012429_4890392.0Zinc fingerPhorbol-ester/DAG-type 2
TgeneDEF8chr1:43825453chr16:90025551ENST00000569453014199_2500452.0Zinc fingerPhorbol-ester/DAG-type 1
TgeneDEF8chr1:43825453chr16:90025551ENST00000569453014429_4890452.0Zinc fingerPhorbol-ester/DAG-type 2
TgeneDEF8chr1:43825453chr16:90025551ENST00000570182013199_2500442.0Zinc fingerPhorbol-ester/DAG-type 1
TgeneDEF8chr1:43825453chr16:90025551ENST00000570182013429_4890442.0Zinc fingerPhorbol-ester/DAG-type 2
TgeneDEF8chr1:43825454chr16:90025552ENST00000268676013199_2500513.0Zinc fingerPhorbol-ester/DAG-type 1
TgeneDEF8chr1:43825454chr16:90025552ENST00000268676013429_4890513.0Zinc fingerPhorbol-ester/DAG-type 2
TgeneDEF8chr1:43825454chr16:90025552ENST0000041839106199_2500198.0Zinc fingerPhorbol-ester/DAG-type 1
TgeneDEF8chr1:43825454chr16:90025552ENST0000041839106429_4890198.0Zinc fingerPhorbol-ester/DAG-type 2
TgeneDEF8chr1:43825454chr16:90025552ENST00000563594013199_2500452.0Zinc fingerPhorbol-ester/DAG-type 1
TgeneDEF8chr1:43825454chr16:90025552ENST00000563594013429_4890452.0Zinc fingerPhorbol-ester/DAG-type 2
TgeneDEF8chr1:43825454chr16:90025552ENST00000563795013199_2500435.0Zinc fingerPhorbol-ester/DAG-type 1
TgeneDEF8chr1:43825454chr16:90025552ENST00000563795013429_4890435.0Zinc fingerPhorbol-ester/DAG-type 2
TgeneDEF8chr1:43825454chr16:90025552ENST00000567874012199_2500392.0Zinc fingerPhorbol-ester/DAG-type 1
TgeneDEF8chr1:43825454chr16:90025552ENST00000567874012429_4890392.0Zinc fingerPhorbol-ester/DAG-type 2
TgeneDEF8chr1:43825454chr16:90025552ENST00000569453014199_2500452.0Zinc fingerPhorbol-ester/DAG-type 1
TgeneDEF8chr1:43825454chr16:90025552ENST00000569453014429_4890452.0Zinc fingerPhorbol-ester/DAG-type 2
TgeneDEF8chr1:43825454chr16:90025552ENST00000570182013199_2500442.0Zinc fingerPhorbol-ester/DAG-type 1
TgeneDEF8chr1:43825454chr16:90025552ENST00000570182013429_4890442.0Zinc fingerPhorbol-ester/DAG-type 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDC20chr1:43825453chr16:90025551ENST00000310955+111182_2210500.0RepeatNote=WD 1
HgeneCDC20chr1:43825453chr16:90025551ENST00000310955+111224_2630500.0RepeatNote=WD 2
HgeneCDC20chr1:43825453chr16:90025551ENST00000310955+111266_3030500.0RepeatNote=WD 3
HgeneCDC20chr1:43825453chr16:90025551ENST00000310955+111307_3460500.0RepeatNote=WD 4
HgeneCDC20chr1:43825453chr16:90025551ENST00000310955+111353_3950500.0RepeatNote=WD 5
HgeneCDC20chr1:43825453chr16:90025551ENST00000310955+111397_4380500.0RepeatNote=WD 6
HgeneCDC20chr1:43825453chr16:90025551ENST00000310955+111441_4800500.0RepeatNote=WD 7
HgeneCDC20chr1:43825453chr16:90025551ENST00000372462+110182_2210500.0RepeatNote=WD 1
HgeneCDC20chr1:43825453chr16:90025551ENST00000372462+110224_2630500.0RepeatNote=WD 2
HgeneCDC20chr1:43825453chr16:90025551ENST00000372462+110266_3030500.0RepeatNote=WD 3
HgeneCDC20chr1:43825453chr16:90025551ENST00000372462+110307_3460500.0RepeatNote=WD 4
HgeneCDC20chr1:43825453chr16:90025551ENST00000372462+110353_3950500.0RepeatNote=WD 5
HgeneCDC20chr1:43825453chr16:90025551ENST00000372462+110397_4380500.0RepeatNote=WD 6
HgeneCDC20chr1:43825453chr16:90025551ENST00000372462+110441_4800500.0RepeatNote=WD 7
HgeneCDC20chr1:43825454chr16:90025552ENST00000310955+111182_2210500.0RepeatNote=WD 1
HgeneCDC20chr1:43825454chr16:90025552ENST00000310955+111224_2630500.0RepeatNote=WD 2
HgeneCDC20chr1:43825454chr16:90025552ENST00000310955+111266_3030500.0RepeatNote=WD 3
HgeneCDC20chr1:43825454chr16:90025552ENST00000310955+111307_3460500.0RepeatNote=WD 4
HgeneCDC20chr1:43825454chr16:90025552ENST00000310955+111353_3950500.0RepeatNote=WD 5
HgeneCDC20chr1:43825454chr16:90025552ENST00000310955+111397_4380500.0RepeatNote=WD 6
HgeneCDC20chr1:43825454chr16:90025552ENST00000310955+111441_4800500.0RepeatNote=WD 7
HgeneCDC20chr1:43825454chr16:90025552ENST00000372462+110182_2210500.0RepeatNote=WD 1
HgeneCDC20chr1:43825454chr16:90025552ENST00000372462+110224_2630500.0RepeatNote=WD 2
HgeneCDC20chr1:43825454chr16:90025552ENST00000372462+110266_3030500.0RepeatNote=WD 3
HgeneCDC20chr1:43825454chr16:90025552ENST00000372462+110307_3460500.0RepeatNote=WD 4
HgeneCDC20chr1:43825454chr16:90025552ENST00000372462+110353_3950500.0RepeatNote=WD 5
HgeneCDC20chr1:43825454chr16:90025552ENST00000372462+110397_4380500.0RepeatNote=WD 6
HgeneCDC20chr1:43825454chr16:90025552ENST00000372462+110441_4800500.0RepeatNote=WD 7


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Fusion Gene Sequence for CDC20-DEF8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>14783_14783_1_CDC20-DEF8_CDC20_chr1_43825453_ENST00000310955_DEF8_chr16_90025551_ENST00000418391_length(transcript)=693nt_BP=470nt
GAGGCGTAAGCCAGGCGTGTTAAAGCCGGTCGGAACTGCTCCGGAGGGCACGGGCTCCGTAGGCACCAACTGCAAGGACCCCTCCCCCTG
CGGGCGCTCCCATGGCACAGTTCGCGTTCGAGAGTGACCTGCACTCGCTGCTTCAGCTGGATGCACCCATCCCCAATGCACCCCCTGCGC
GCTGGCAGCGCAAAGCCAAGGAAGCCGCAGGCCCGGCCCCCTCACCCATGCGGGCCGCCAACCGATCCCACAGCGCCGGCAGGACTCCGG
GCCGAACTCCTGGCAAATCCAGTTCCAAGGTTCAGACCACTCCTAGCAAACCTGGCGGTGACCGCTATATCCCCCATCGCAGTGCTGCCC
AGATGGAGGTGGCCAGCTTCCTCCTGAGCAAGGAGAACCAGCCTGAAAACAGCCAGACGCCCACCAAGAAGTCCTTCGGCTCAGTGGAAA
ACCACAAAATGCGCCAGAGGACACCTGCACAGGTGGGCCGAGACCCAGACGAGGAGTGAGGAATGAGAGAGACCAAAGTTCCTGCCTCCG
CTGGGCTCACATTCAGATGTGAGCTATCCAGTGTGGTGGCCACTAGCCAAACATGGCCAGTCAAAGTTAAATTAACTAAATATGCATTTC
CTCGTTGTACTGTCTACATTGGACAGGGCTGTTCTGGATGAGAAATTAAACTAGTGAATTACA

>14783_14783_1_CDC20-DEF8_CDC20_chr1_43825453_ENST00000310955_DEF8_chr16_90025551_ENST00000418391_length(amino acids)=135AA_BP=
MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAPSPMRAANRSHSAGRTPGRTPGKSSSKVQTTPSKPGGDRYIPHRSAAQMEV
ASFLLSKENQPENSQTPTKKSFGSVENHKMRQRTPAQVGRDPDEE

--------------------------------------------------------------
>14783_14783_2_CDC20-DEF8_CDC20_chr1_43825453_ENST00000372462_DEF8_chr16_90025551_ENST00000418391_length(transcript)=795nt_BP=572nt
GGTGGTGGGGCTGAGCCGAGGTGGGGCCGTGGCCAGGGGGAGGGGGTGCTAGGCCGGAAGGGGCTGCAGCCGAGGGTGGCCCTGATTTTG
TGGCCGGCCAGGAGCGAAGGGGTCCCTTTCTGTCCCCTGAGCACCGTCGCCTCCTTTCCTCCAGGGCTCCGTAGGCACCAACTGCAAGGA
CCCCTCCCCCTGCGGGCGCTCCCATGGCACAGTTCGCGTTCGAGAGTGACCTGCACTCGCTGCTTCAGCTGGATGCACCCATCCCCAATG
CACCCCCTGCGCGCTGGCAGCGCAAAGCCAAGGAAGCCGCAGGCCCGGCCCCCTCACCCATGCGGGCCGCCAACCGATCCCACAGCGCCG
GCAGGACTCCGGGCCGAACTCCTGGCAAATCCAGTTCCAAGGTTCAGACCACTCCTAGCAAACCTGGCGGTGACCGCTATATCCCCCATC
GCAGTGCTGCCCAGATGGAGGTGGCCAGCTTCCTCCTGAGCAAGGAGAACCAGCCTGAAAACAGCCAGACGCCCACCAAGAAGTCCTTCG
GCTCAGTGGAAAACCACAAAATGCGCCAGAGGACACCTGCACAGGTGGGCCGAGACCCAGACGAGGAGTGAGGAATGAGAGAGACCAAAG
TTCCTGCCTCCGCTGGGCTCACATTCAGATGTGAGCTATCCAGTGTGGTGGCCACTAGCCAAACATGGCCAGTCAAAGTTAAATTAACTA
AATATGCATTTCCTCGTTGTACTGTCTACATTGGACAGGGCTGTTCTGGATGAGAAATTAAACTAGTGAATTACA

>14783_14783_2_CDC20-DEF8_CDC20_chr1_43825453_ENST00000372462_DEF8_chr16_90025551_ENST00000418391_length(amino acids)=141AA_BP=
MQPRVALILWPARSEGVPFCPLSTVASFPPGLRRHQLQGPLPLRALPWHSSRSRVTCTRCFSWMHPSPMHPLRAGSAKPRKPQARPPHPC
GPPTDPTAPAGLRAELLANPVPRFRPLLANLAVTAISPIAVLPRWRWPASS

--------------------------------------------------------------
>14783_14783_3_CDC20-DEF8_CDC20_chr1_43825454_ENST00000310955_DEF8_chr16_90025552_ENST00000418391_length(transcript)=691nt_BP=469nt
GAGGCGTAAGCCAGGCGTGTTAAAGCCGGTCGGAACTGCTCCGGAGGGCACGGGCTCCGTAGGCACCAACTGCAAGGACCCCTCCCCCTG
CGGGCGCTCCCATGGCACAGTTCGCGTTCGAGAGTGACCTGCACTCGCTGCTTCAGCTGGATGCACCCATCCCCAATGCACCCCCTGCGC
GCTGGCAGCGCAAAGCCAAGGAAGCCGCAGGCCCGGCCCCCTCACCCATGCGGGCCGCCAACCGATCCCACAGCGCCGGCAGGACTCCGG
GCCGAACTCCTGGCAAATCCAGTTCCAAGGTTCAGACCACTCCTAGCAAACCTGGCGGTGACCGCTATATCCCCCATCGCAGTGCTGCCC
AGATGGAGGTGGCCAGCTTCCTCCTGAGCAAGGAGAACCAGCCTGAAAACAGCCAGACGCCCACCAAGAAGCCTTCGGCTCAGTGGAAAA
CCACAAAATGCGCCAGAGGCACCTGCACAGGTGGGCCGAGACCCAGACGAGGAGTGAGGAATGAGAGAGACCAAAGTTCCTGCCTCCGCT
GGGCTCACATTCAGATGTGAGCTATCCAGTGTGGTGGCCACTAGCCAAACATGGCCAGTCAAAGTTAAATTAACTAAATATGCATTTCCT
CGTTGTACTGTCTACATTGGACAGGGCTGTTCTGGATGAGAAATTAAACTAGTGAATTACA

>14783_14783_3_CDC20-DEF8_CDC20_chr1_43825454_ENST00000310955_DEF8_chr16_90025552_ENST00000418391_length(amino acids)=152AA_BP=123
MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAPSPMRAANRSHSAGRTPGRTPGKSSSKVQTTPSKPGGDRYIPHRSAAQMEV
ASFLLSKENQPENSQTPTKKPSAQWKTTKCARGTCTGGPRPRRGVRNERDQSSCLRWAHIQM

--------------------------------------------------------------
>14783_14783_4_CDC20-DEF8_CDC20_chr1_43825454_ENST00000372462_DEF8_chr16_90025552_ENST00000418391_length(transcript)=793nt_BP=571nt
GGTGGTGGGGCTGAGCCGAGGTGGGGCCGTGGCCAGGGGGAGGGGGTGCTAGGCCGGAAGGGGCTGCAGCCGAGGGTGGCCCTGATTTTG
TGGCCGGCCAGGAGCGAAGGGGTCCCTTTCTGTCCCCTGAGCACCGTCGCCTCCTTTCCTCCAGGGCTCCGTAGGCACCAACTGCAAGGA
CCCCTCCCCCTGCGGGCGCTCCCATGGCACAGTTCGCGTTCGAGAGTGACCTGCACTCGCTGCTTCAGCTGGATGCACCCATCCCCAATG
CACCCCCTGCGCGCTGGCAGCGCAAAGCCAAGGAAGCCGCAGGCCCGGCCCCCTCACCCATGCGGGCCGCCAACCGATCCCACAGCGCCG
GCAGGACTCCGGGCCGAACTCCTGGCAAATCCAGTTCCAAGGTTCAGACCACTCCTAGCAAACCTGGCGGTGACCGCTATATCCCCCATC
GCAGTGCTGCCCAGATGGAGGTGGCCAGCTTCCTCCTGAGCAAGGAGAACCAGCCTGAAAACAGCCAGACGCCCACCAAGAAGCCTTCGG
CTCAGTGGAAAACCACAAAATGCGCCAGAGGCACCTGCACAGGTGGGCCGAGACCCAGACGAGGAGTGAGGAATGAGAGAGACCAAAGTT
CCTGCCTCCGCTGGGCTCACATTCAGATGTGAGCTATCCAGTGTGGTGGCCACTAGCCAAACATGGCCAGTCAAAGTTAAATTAACTAAA
TATGCATTTCCTCGTTGTACTGTCTACATTGGACAGGGCTGTTCTGGATGAGAAATTAAACTAGTGAATTACA

>14783_14783_4_CDC20-DEF8_CDC20_chr1_43825454_ENST00000372462_DEF8_chr16_90025552_ENST00000418391_length(amino acids)=152AA_BP=123
MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAPSPMRAANRSHSAGRTPGRTPGKSSSKVQTTPSKPGGDRYIPHRSAAQMEV
ASFLLSKENQPENSQTPTKKPSAQWKTTKCARGTCTGGPRPRRGVRNERDQSSCLRWAHIQM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CDC20-DEF8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDC20-DEF8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDC20-DEF8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDC20C2239176Liver carcinoma1CTD_human