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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:IQSEC1-WNT7A (FusionGDB2 ID:HG9922TG7476)

Fusion Gene Summary for IQSEC1-WNT7A

Fusion gene summary

Fusion gene information	Fusion gene name: IQSEC1-WNT7A
	Fusion gene ID: hg9922tg7476
		Hgene	Tgene
	Gene symbol	IQSEC1	WNT7A
	Gene ID	9922	7476
	Gene name	IQ motif and Sec7 domain ArfGEF 1	Wnt family member 7A
	Synonyms	ARF-GEP100\|ARFGEP100\|BRAG2\|GEP100\|IDDSSBA	Wnt-7a
	Cytomap	('IQSEC1')('WNT7A') 3p25.2-p25.1	3p25.1
	Type of gene	protein-coding	protein-coding
	Description	IQ motif and SEC7 domain-containing protein 1ADP-ribosylation factors guanine nucleotide-exchange protein 100ADP-ribosylation factors guanine nucleotide-exchange protein 2IQ motif and Sec7 domain 1brefeldin A-resistant ARF-GEF2brefeldin-resistant Arf	protein Wnt-7aproto-oncogene Wnt7a proteinwingless-type MMTV integration site family, member 7A
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000273221, ENST00000473088,
Fusion gene scores	* DoF score	5 X 10 X 4=200	4 X 3 X 4=48
	# samples	6	6
	** MAII score	log2(6/200*10)=-1.73696559416621 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: IQSEC1 [Title/Abstract] AND WNT7A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	IQSEC1(12954928)-WNT7A(13916670), # samples:3
Anticipated loss of major functional domain due to fusion event.	IQSEC1-WNT7A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. IQSEC1-WNT7A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. IQSEC1-WNT7A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. IQSEC1-WNT7A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. IQSEC1-WNT7A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. IQSEC1-WNT7A seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	WNT7A	GO:0001502	cartilage condensation	17202865
Tgene	WNT7A	GO:0002062	chondrocyte differentiation	17202865
Tgene	WNT7A	GO:0021846	cell proliferation in forebrain	12843296
Tgene	WNT7A	GO:0032270	positive regulation of cellular protein metabolic process	16805831
Tgene	WNT7A	GO:0035313	wound healing, spreading of epidermal cells	15802269
Tgene	WNT7A	GO:0045893	positive regulation of transcription, DNA-templated	15802269
Tgene	WNT7A	GO:0045944	positive regulation of transcription by RNA polymerase II	12857724
Tgene	WNT7A	GO:0048864	stem cell development	12843296
Tgene	WNT7A	GO:0050768	negative regulation of neurogenesis	12843296
Tgene	WNT7A	GO:0051965	positive regulation of synapse assembly	18986540
Tgene	WNT7A	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing	15802269
Tgene	WNT7A	GO:0060070	canonical Wnt signaling pathway	12857724\|15802269\|16805831\|18986540\|28733458
Tgene	WNT7A	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	15802269
Tgene	WNT7A	GO:0060997	dendritic spine morphogenesis	21670302
Tgene	WNT7A	GO:1904891	positive regulation of excitatory synapse assembly	21670302
Tgene	WNT7A	GO:1905606	regulation of presynapse assembly	20530549
Tgene	WNT7A	GO:2000463	positive regulation of excitatory postsynaptic potential	21670302

Fusion gene breakpoints across IQSEC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across WNT7A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-GV-A3JV-01A	IQSEC1	chr3	12954928	-	WNT7A	chr3	13916670	-
ChimerDB4	BLCA	TCGA-GV-A3JV-01A	IQSEC1	chr3	12961930	-	WNT7A	chr3	13916670	-
ChimerDB4	BLCA	TCGA-GV-A3JV-01A	IQSEC1	chr3	12963620	-	WNT7A	chr3	13916670	-
ChimerDB4	BLCA	TCGA-GV-A3JV	IQSEC1	chr3	12954927	-	WNT7A	chr3	13916670	-
ChimerDB4	BLCA	TCGA-GV-A3JV	IQSEC1	chr3	12961929	-	WNT7A	chr3	13916670	-
ChimerDB4	BLCA	TCGA-GV-A3JV	IQSEC1	chr3	12963619	-	WNT7A	chr3	13916670	-

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Fusion Gene ORF analysis for IQSEC1-WNT7A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000273221	ENST00000497808	IQSEC1	chr3	12954928	-	WNT7A	chr3	13916670	-
5CDS-5UTR	ENST00000273221	ENST00000497808	IQSEC1	chr3	12961930	-	WNT7A	chr3	13916670	-
5CDS-5UTR	ENST00000273221	ENST00000497808	IQSEC1	chr3	12963620	-	WNT7A	chr3	13916670	-
5CDS-5UTR	ENST00000273221	ENST00000497808	IQSEC1	chr3	12954927	-	WNT7A	chr3	13916670	-
5CDS-5UTR	ENST00000273221	ENST00000497808	IQSEC1	chr3	12961929	-	WNT7A	chr3	13916670	-
5CDS-5UTR	ENST00000273221	ENST00000497808	IQSEC1	chr3	12963619	-	WNT7A	chr3	13916670	-
Frame-shift	ENST00000273221	ENST00000285018	IQSEC1	chr3	12954928	-	WNT7A	chr3	13916670	-
Frame-shift	ENST00000273221	ENST00000285018	IQSEC1	chr3	12961930	-	WNT7A	chr3	13916670	-
Frame-shift	ENST00000273221	ENST00000285018	IQSEC1	chr3	12954927	-	WNT7A	chr3	13916670	-
Frame-shift	ENST00000273221	ENST00000285018	IQSEC1	chr3	12961929	-	WNT7A	chr3	13916670	-
In-frame	ENST00000273221	ENST00000285018	IQSEC1	chr3	12963620	-	WNT7A	chr3	13916670	-
In-frame	ENST00000273221	ENST00000285018	IQSEC1	chr3	12963619	-	WNT7A	chr3	13916670	-
intron-3CDS	ENST00000473088	ENST00000285018	IQSEC1	chr3	12954928	-	WNT7A	chr3	13916670	-
intron-3CDS	ENST00000473088	ENST00000285018	IQSEC1	chr3	12961930	-	WNT7A	chr3	13916670	-
intron-3CDS	ENST00000473088	ENST00000285018	IQSEC1	chr3	12963620	-	WNT7A	chr3	13916670	-
intron-3CDS	ENST00000473088	ENST00000285018	IQSEC1	chr3	12954927	-	WNT7A	chr3	13916670	-
intron-3CDS	ENST00000473088	ENST00000285018	IQSEC1	chr3	12961929	-	WNT7A	chr3	13916670	-
intron-3CDS	ENST00000473088	ENST00000285018	IQSEC1	chr3	12963619	-	WNT7A	chr3	13916670	-
intron-5UTR	ENST00000473088	ENST00000497808	IQSEC1	chr3	12954928	-	WNT7A	chr3	13916670	-
intron-5UTR	ENST00000473088	ENST00000497808	IQSEC1	chr3	12961930	-	WNT7A	chr3	13916670	-
intron-5UTR	ENST00000473088	ENST00000497808	IQSEC1	chr3	12963620	-	WNT7A	chr3	13916670	-
intron-5UTR	ENST00000473088	ENST00000497808	IQSEC1	chr3	12954927	-	WNT7A	chr3	13916670	-
intron-5UTR	ENST00000473088	ENST00000497808	IQSEC1	chr3	12961929	-	WNT7A	chr3	13916670	-
intron-5UTR	ENST00000473088	ENST00000497808	IQSEC1	chr3	12963619	-	WNT7A	chr3	13916670	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000273221	IQSEC1	chr3	12963619	-	ENST00000285018	WNT7A	chr3	13916670	-	5777	2112	217	3090	957
ENST00000273221	IQSEC1	chr3	12963620	-	ENST00000285018	WNT7A	chr3	13916670	-	5777	2112	217	3090	957

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000273221	ENST00000285018	IQSEC1	chr3	12963619	-	WNT7A	chr3	13916670	-	0.001061745	0.99893826
ENST00000273221	ENST00000285018	IQSEC1	chr3	12963620	-	WNT7A	chr3	13916670	-	0.001061745	0.99893826

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Fusion Genomic Features for IQSEC1-WNT7A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for IQSEC1-WNT7A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:12954928/chr3:13916670)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

IQSEC1

chr3:12963619

chr3:13916670

ENST00000273221

134_163

631

964.0

Domain

Hgene

IQSEC1

chr3:12963620

chr3:13916670

ENST00000273221

134_163

631

964.0

Domain

Tgene

WNT7A

chr3:12963619

chr3:13916670

ENST00000285018

238_266

350.0

Region

Intrinsically disordered linker

Tgene

WNT7A

chr3:12963620

chr3:13916670

ENST00000285018

238_266

350.0

Region

Intrinsically disordered linker

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

IQSEC1

chr3:12963619

chr3:13916670

ENST00000273221

848_879

631

964.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

IQSEC1

chr3:12963620

chr3:13916670

ENST00000273221

848_879

631

964.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

IQSEC1

chr3:12963619

chr3:13916670

ENST00000273221

517_710

631

964.0

Domain

SEC7

Hgene

IQSEC1

chr3:12963619

chr3:13916670

ENST00000273221

774_866

631

964.0

Domain

Note=PH

Hgene

IQSEC1

chr3:12963620

chr3:13916670

ENST00000273221

517_710

631

964.0

Domain

SEC7

Hgene

IQSEC1

chr3:12963620

chr3:13916670

ENST00000273221

774_866

631

964.0

Domain

Note=PH

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Fusion Gene Sequence for IQSEC1-WNT7A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>40196_40196_1_IQSEC1-WNT7A_IQSEC1_chr3_12963619_ENST00000273221_WNT7A_chr3_13916670_ENST00000285018_length(transcript)=5777nt_BP=2112nt
GCGGGCTTGGCTGGCCTGGGGCTCGGACTTGGGGCCGGAGCCGCGGGAGCCGGCGGACGCTGGACCAGGAGCCCCGACGTGATCGCGTGG
CGGGTGGTCGGGTCTCCGGGTGGCCGGGTGTCGGCCCCGGGATCCGGCGGCTCGCTGGCGGGAGTCGGCGGCCTCTGCTGGGCCTGGGTC
CCGGCTCCCGGCCCGGCCCGCTCCCACTGCGGCCGCCATGTGGTGCCTGCACTGCAACTCGGAGAGGACCCAGTCCCTTCTGGAGCTAGA
GCTTGACAGCGGCGTCGAGGGCGAGGCCCCCAGCAGTGAGACTGGCACATCCCTGGACAGCCCCTCAGCCTACCCCCAGGGCCCCTTGGT
GCCCGGTTCCAGCCTGAGCCCGGATCACTACGAGCACACGTCAGTGGGAGCCTATGGGCTGTACTCGGGGCCGCCGGGGCAACAGCAGCG
CACGCGGAGGCCCAAGCTGCAGCACTCGACCTCCATCCTGCGCAAGCAGGCTGAGGAGGAGGCCATCAAGCGCTCACGCTCACTCTCCGA
GAGCTATGAGCTCTCCTCGGACCTGCAGGACAAGCAGGTGGAGATGCTAGAACGAAAGTATGGGGGGCGCCTGGTAACCCGCCATGCGGC
CCGCACCATCCAGACGGCGTTTCGCCAGTACCAGATGAACAAGAACTTCGAGCGCTTGCGCAGCTCCATGTCAGAGAACCGCATGTCACG
CCGGATTGTGCTGTCCAACATGAGGATGCAGTTCTCCTTTGAGGGGCCTGAGAAAGTGCACAGCTCCTACTTCGAGGGGAAGCAGGTCTC
AGTGACTAACGACGGCTCCCAGCTGGGAGCCCTGGTGTCCCCTGAGTGTGGTGACCTCAGCGAGCCCACCACCCTCAAGTCTCCGGCCCC
CTCCAGTGACTTTGCGGACGCCATCACCGAGCTGGAGGACGCCTTCTCTAGGCAAGTGAAATCACTGGCCGAGTCCATCGACGATGCCCT
CAACTGCCGCAGCCTGCACACTGAGGAGGCACCGGCCCTGGATGCGGCGCGGGCCCGGGACACCGAACCCCAGACAGCCCTGCACGGCAT
GGACCACCGCAAACTGGACGAGATGACGGCCTCGTACAGTGATGTCACCCTGTACATCGATGAGGAGGAGCTGTCGCCCCCTCTGCCCCT
CTCGCAGGCAGGGGACCGGCCGTCCAGCACCGAGTCGGACCTGCGGCTACGGGCTGGGGGCGCAGCCCCAGACTACTGGGCCCTGGCCCA
CAAAGAGGACAAGGCTGACACGGACACGAGCTGCCGGAGCACGCCGTCGCTGGAGCGGCAGGAGCAGCGGCTGCGGGTGGAGCATCTGCC
GCTGCTCACCATCGAGCCACCCAGCGACAGCTCTGTGGACCTTAGTGACCGCTCGGAGCGGGGGTCACTCAAGAGGCAGAGTGCTTACGA
GCGCAGCCTTGGCGGGCAGCAGGGCAGTCCCAAGCATGGTCCCCACAGCGGCGCCCCCAAGAGCCTCCCCCGGGAGGAGCCTGAGTTGCG
GCCCCGGCCCCCCAGGCCCCTGGACAGCCACTTGGCCATCAATGGCTCAGCCAACCGGCAGAGCAAGTCTGAGTCGGACTACTCAGACGG
TGACAATGACAGCATCAACAGCACGTCCAACTCCAACGATACCATCAACTGCAGCTCCGAGTCATCGTCCCGTGACAGCCTGCGGGAGCA
GACGCTCAGCAAGCAGACCTACCACAAGGAGGCCCGCAACAGCTGGGACTCGCCTGCCTTTAGCAACGATGTCATCCGCAAGAGGCACTA
CCGCATCGGCCTGAACCTCTTCAACAAGAAGCCTGAGAAGGGAGTCCAGTACCTCATCGAGCGTGGCTTTGTGCCCGACACGCCCGTCGG
GGTGGCCCACTTCCTGCTGCAGCGCAAGGGCCTCAGCCGGCAGATGATCGGCGAGTTCCTGGGCAACCGGCAGAAGCAGTTCAACCGTGA
CGTGCTCGACTGCGTCGTGGACGAGATGGACTTCTCTACCATGGAGCTGGATGAGGCCCTCAGGAAATTCCAGGCGCACATCCGTGTCCA
AGGGGAGGCTCAGAAAGTGGAGCGGCTCATAGAGGCGTTCAGTGGCTTCTCCTCAGTGGTAGCTCTGGGCGCAAGCATCATCTGTAACAA
GATCCCAGGCCTGGCTCCCAGACAGCGGGCGATCTGCCAGAGCCGGCCCGACGCCATCATCGTCATAGGAGAAGGCTCACAAATGGGCCT
GGACGAGTGTCAGTTTCAGTTCCGCAATGGCCGCTGGAACTGCTCTGCACTGGGAGAGCGCACCGTCTTCGGGAAGGAGCTCAAAGTGGG
GAGCCGGGAGGCTGCGTTCACCTACGCCATCATTGCCGCCGGCGTGGCCCACGCCATCACAGCTGCCTGTACCCAGGGCAACCTGAGCGA
CTGTGGCTGCGACAAAGAGAAGCAAGGCCAGTACCACCGGGACGAGGGCTGGAAGTGGGGTGGCTGCTCTGCCGACATCCGCTACGGCAT
CGGCTTCGCCAAGGTCTTTGTGGATGCCCGGGAGATCAAGCAGAATGCCCGGACTCTCATGAACTTGCACAACAACGAGGCAGGCCGAAA
GATCCTGGAGGAGAACATGAAGCTGGAATGTAAGTGCCACGGCGTGTCAGGCTCGTGCACCACCAAGACGTGCTGGACCACACTGCCACA
GTTTCGGGAGCTGGGCTACGTGCTCAAGGACAAGTACAACGAGGCCGTTCACGTGGAGCCTGTGCGTGCCAGCCGCAACAAGCGGCCCAC
CTTCCTGAAGATCAAGAAGCCACTGTCGTACCGCAAGCCCATGGACACGGACCTGGTGTACATCGAGAAGTCGCCCAACTACTGCGAGGA
GGACCCGGTGACCGGCAGTGTGGGCACCCAGGGCCGCGCCTGCAACAAGACGGCTCCCCAGGCCAGCGGCTGTGACCTCATGTGCTGTGG
GCGTGGCTACAACACCCACCAGTACGCCCGCGTGTGGCAGTGCAACTGTAAGTTCCACTGGTGCTGCTATGTCAAGTGCAACACGTGCAG
CGAGCGCACGGAGATGTACACGTGCAAGTGAGCCCCGTGTGCACACCACCCTCCCGCTGCAAGTCAGATTGCTGGGAGGACTGGACCGTT
TCCAAGCTGCGGGCTCCCTGGCAGGATGCTGAGCTTGTCTTTTCTGCTGAGGAGGGTACTTTTCCTGGGTTTCCTGCAGGCATCCGTGGG
GGAAAAAAAATCTCTCAGAGCCCTCAACTATTCTGTTCCACACCCAATGCTGCTCCACCCTCCCCCAGACACAGCCCAGGTCCCTCCGCG
GCTGGAGCGAAGCCTTCTGCAGCAGGAACTCTGGACCCCTGGGCCTCATCACAGCAATATTTAACAATTTATTCTGATAAAAATAATATT
AATTTATTTAATTAAAAAGAATTCTTCCACCTCGTCGGGATCCGTTTTCTGCAATCAAAGTGGACTGCTTGCTTTCCTAGCAGGATGATT
TTGTTGCTAGGACAAGGAGCCGTGTAGAAGTGTACATAACTATTCTTTATGCAGATATTTCTACTAGCTGATTTTGCAGGTACCCACCTT
GCAGCACTAGATGTTTAAGTACAAGAGGAGACATCTTTTATGCATATATAGATATACACACACACATTTTTTTTTTTTTTTTTGCTGTTT
GCTGCTACTTATCCAGAAATTTAAGCTGGTCCAGATTTGGAGACGTTTTTTCCAGAGTATGTTTTCCATCCTTTTGCCCTCCCCAGTTCA
AACTTCACCATTAGAAAAATCCAGTTTGGAATAAATAGAGAGGAAAAATAATAAATTCCCAGCAGTTTCCATCTTTCGGAAAGTGAGCCA
CCGGATAAGAGAGAATATTTTGTAAGAGACTATTTTTATATGAATATTTTATTTATATCGAGTCTACTGTATCATTCCACGGCCTGTGCT
TCTTCTTAATTCTGGTACTCACTTAGGGGTAAGGAGGGGCGATGCCTGGTTGTGGCGTCAGGCCCCATGGGGCCCCTTGCACAGCTGGAT
TCTTGAGTTCTGTTTGCCAAGTGGGCACAAGCTGCCCCTGGATGCCTGGGGTTGAGGCATCATCTCATCCATGTTAGCCGGGAAAGAAAT
CAAATCCCCAGCCTCAGCCTGTTAAGCTCAGGCCTTTCAAGCAGGGCCACTGAGTGGTAGCTTCGAAATGAGTCACTGTGGTGGGTGGTC
ATCGTGCCCCTCACAGGGACTTGACCGTCATCCTGCAGCAGAGGCCAGTTCAGGGAGCCCCACACCTCACCAAGACACTAGCCATTGCCT
GCGTGTCCTGGAAGGTGAGATGTAGTCCTCAGGTGAGGTGACCCAAAGCAGATGGGGTGAGGGGCCGATGAGCAGCCGGGCCCAGCGGGG
CTTCCTGGATATCCTGCTCCCAAGGCCAAGCAGCAGAGAGAGGTTCAAGTGAGGCCACTTTGCTTTGGGTCCAGCTACACCCAGAGCCTC
AGCCTAGAAAGCTGTCCTCCAGCAGGCTGGGGGTGTTCTAATATGTGTCCGTTTGCATTTCCGGTGTGTGTGTGTGTGTGTGTGTGTGTG
TGTGTGTGTGTGTGTGTGTGTACTGTATCTTCTTAGGGACTTGAGTGTAGTCACGTGACTTTGCGCCTTGCAGCGCCTCCGCCGTACTCG
TGTGTGTATGTGTCTGTGTGTTTCCGTGCTACCCAAGCGTCTGTTTCTCTCCGTGTGCCTGGGAGATCAGGTCTCAGGCATGGAGCTGCA
TGCCTTTGCATCTGCTGCTCCCCAGAGTCTCTGCTTGCATGTGAGGGCTGGTGGTATGAGGCAGACAGCAGAGATTGTGTGTGATTGTGT
TGAACCGCCAAGAGAAGGCACCTCTGAACTCTGTCCCCACACCCATGGGTGAAAACCAGACACCTCTGAGACCACAGCACAGCCCCATGG
CCCCACCTGCTGGGAGCCCTTCAGTATCTAGGCTGTGTCTGACTCCTCAGTGTCCACACTGAGCCTGGATCACAGCATGGGCAAATAAAA
GTGACTGGATGGTTGCATGGTTTCTTCCCTTGGACATTTTTTTCCATTTTTCTTTTACTTGGGTGTCTGGAGGAGTGGGCATGTGAAGGG
GCCATGGAGTGAATGGATGGAGGGATGGATGAATGTGTGAGTAGGTAGGTAGGTGAATGGGTAGATGTGTGGATGGATAAGTAGGTGGGT
GGGTGAATGGATAAATGGATGGATGGGTAGATGGATGGATGAAGGGATAAACAGATGGGTGGATGGATTGATAAGTGAGCGGATGAATGG
ATGAATAGCTAGGAAAGTGGGTGGGTGGATGAGGGTGGGTTGATGAGGTAGGTACACCTACAGATAGGTAAGTGAGCAGTTTCTTGGGAG
TCCACAGGTCACATTTTATCTTTGCTTTGGAAAACCTAGCAGATCTGCCATGATCAGGATGGCTTCCCGACCTTGCAACCCTTCTGCTTC
TGACCTCCTTGGCACCTGGGAATGGGGGAGATTCTGACCAGCCTCCCCAGATGAGTGTTCAATGATAGTTACATAAACACAGTCTCAGAA
GAGTCATCCCTGTGTCCTCCCTCACTGTGGGTTCCCAGCTCTGGGGCCTGCCCTCTCTCGGGTGCCCTGTTCAGCTGTGCTCTGAGCCCC
AGTTTCTCCACCTGTGAAATCAGAATAACACCTACCTCACAGGGCTGTTGTGAGGATCCTCCCAGTAATGACTGTATGGCACTTTGAGTT

>40196_40196_1_IQSEC1-WNT7A_IQSEC1_chr3_12963619_ENST00000273221_WNT7A_chr3_13916670_ENST00000285018_length(amino acids)=957AA_BP=631
MWCLHCNSERTQSLLELELDSGVEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPGQQQRTRRPKLQHSTSI
LRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFS
FEGPEKVHSSYFEGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPA
LDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCR
STPSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSHLA
INGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPE
KGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEA
FSGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIA
AGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKC
HGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGR

--------------------------------------------------------------
>40196_40196_2_IQSEC1-WNT7A_IQSEC1_chr3_12963620_ENST00000273221_WNT7A_chr3_13916670_ENST00000285018_length(transcript)=5777nt_BP=2112nt
GCGGGCTTGGCTGGCCTGGGGCTCGGACTTGGGGCCGGAGCCGCGGGAGCCGGCGGACGCTGGACCAGGAGCCCCGACGTGATCGCGTGG
CGGGTGGTCGGGTCTCCGGGTGGCCGGGTGTCGGCCCCGGGATCCGGCGGCTCGCTGGCGGGAGTCGGCGGCCTCTGCTGGGCCTGGGTC
CCGGCTCCCGGCCCGGCCCGCTCCCACTGCGGCCGCCATGTGGTGCCTGCACTGCAACTCGGAGAGGACCCAGTCCCTTCTGGAGCTAGA
GCTTGACAGCGGCGTCGAGGGCGAGGCCCCCAGCAGTGAGACTGGCACATCCCTGGACAGCCCCTCAGCCTACCCCCAGGGCCCCTTGGT
GCCCGGTTCCAGCCTGAGCCCGGATCACTACGAGCACACGTCAGTGGGAGCCTATGGGCTGTACTCGGGGCCGCCGGGGCAACAGCAGCG
CACGCGGAGGCCCAAGCTGCAGCACTCGACCTCCATCCTGCGCAAGCAGGCTGAGGAGGAGGCCATCAAGCGCTCACGCTCACTCTCCGA
GAGCTATGAGCTCTCCTCGGACCTGCAGGACAAGCAGGTGGAGATGCTAGAACGAAAGTATGGGGGGCGCCTGGTAACCCGCCATGCGGC
CCGCACCATCCAGACGGCGTTTCGCCAGTACCAGATGAACAAGAACTTCGAGCGCTTGCGCAGCTCCATGTCAGAGAACCGCATGTCACG
CCGGATTGTGCTGTCCAACATGAGGATGCAGTTCTCCTTTGAGGGGCCTGAGAAAGTGCACAGCTCCTACTTCGAGGGGAAGCAGGTCTC
AGTGACTAACGACGGCTCCCAGCTGGGAGCCCTGGTGTCCCCTGAGTGTGGTGACCTCAGCGAGCCCACCACCCTCAAGTCTCCGGCCCC
CTCCAGTGACTTTGCGGACGCCATCACCGAGCTGGAGGACGCCTTCTCTAGGCAAGTGAAATCACTGGCCGAGTCCATCGACGATGCCCT
CAACTGCCGCAGCCTGCACACTGAGGAGGCACCGGCCCTGGATGCGGCGCGGGCCCGGGACACCGAACCCCAGACAGCCCTGCACGGCAT
GGACCACCGCAAACTGGACGAGATGACGGCCTCGTACAGTGATGTCACCCTGTACATCGATGAGGAGGAGCTGTCGCCCCCTCTGCCCCT
CTCGCAGGCAGGGGACCGGCCGTCCAGCACCGAGTCGGACCTGCGGCTACGGGCTGGGGGCGCAGCCCCAGACTACTGGGCCCTGGCCCA
CAAAGAGGACAAGGCTGACACGGACACGAGCTGCCGGAGCACGCCGTCGCTGGAGCGGCAGGAGCAGCGGCTGCGGGTGGAGCATCTGCC
GCTGCTCACCATCGAGCCACCCAGCGACAGCTCTGTGGACCTTAGTGACCGCTCGGAGCGGGGGTCACTCAAGAGGCAGAGTGCTTACGA
GCGCAGCCTTGGCGGGCAGCAGGGCAGTCCCAAGCATGGTCCCCACAGCGGCGCCCCCAAGAGCCTCCCCCGGGAGGAGCCTGAGTTGCG
GCCCCGGCCCCCCAGGCCCCTGGACAGCCACTTGGCCATCAATGGCTCAGCCAACCGGCAGAGCAAGTCTGAGTCGGACTACTCAGACGG
TGACAATGACAGCATCAACAGCACGTCCAACTCCAACGATACCATCAACTGCAGCTCCGAGTCATCGTCCCGTGACAGCCTGCGGGAGCA
GACGCTCAGCAAGCAGACCTACCACAAGGAGGCCCGCAACAGCTGGGACTCGCCTGCCTTTAGCAACGATGTCATCCGCAAGAGGCACTA
CCGCATCGGCCTGAACCTCTTCAACAAGAAGCCTGAGAAGGGAGTCCAGTACCTCATCGAGCGTGGCTTTGTGCCCGACACGCCCGTCGG
GGTGGCCCACTTCCTGCTGCAGCGCAAGGGCCTCAGCCGGCAGATGATCGGCGAGTTCCTGGGCAACCGGCAGAAGCAGTTCAACCGTGA
CGTGCTCGACTGCGTCGTGGACGAGATGGACTTCTCTACCATGGAGCTGGATGAGGCCCTCAGGAAATTCCAGGCGCACATCCGTGTCCA
AGGGGAGGCTCAGAAAGTGGAGCGGCTCATAGAGGCGTTCAGTGGCTTCTCCTCAGTGGTAGCTCTGGGCGCAAGCATCATCTGTAACAA
GATCCCAGGCCTGGCTCCCAGACAGCGGGCGATCTGCCAGAGCCGGCCCGACGCCATCATCGTCATAGGAGAAGGCTCACAAATGGGCCT
GGACGAGTGTCAGTTTCAGTTCCGCAATGGCCGCTGGAACTGCTCTGCACTGGGAGAGCGCACCGTCTTCGGGAAGGAGCTCAAAGTGGG
GAGCCGGGAGGCTGCGTTCACCTACGCCATCATTGCCGCCGGCGTGGCCCACGCCATCACAGCTGCCTGTACCCAGGGCAACCTGAGCGA
CTGTGGCTGCGACAAAGAGAAGCAAGGCCAGTACCACCGGGACGAGGGCTGGAAGTGGGGTGGCTGCTCTGCCGACATCCGCTACGGCAT
CGGCTTCGCCAAGGTCTTTGTGGATGCCCGGGAGATCAAGCAGAATGCCCGGACTCTCATGAACTTGCACAACAACGAGGCAGGCCGAAA
GATCCTGGAGGAGAACATGAAGCTGGAATGTAAGTGCCACGGCGTGTCAGGCTCGTGCACCACCAAGACGTGCTGGACCACACTGCCACA
GTTTCGGGAGCTGGGCTACGTGCTCAAGGACAAGTACAACGAGGCCGTTCACGTGGAGCCTGTGCGTGCCAGCCGCAACAAGCGGCCCAC
CTTCCTGAAGATCAAGAAGCCACTGTCGTACCGCAAGCCCATGGACACGGACCTGGTGTACATCGAGAAGTCGCCCAACTACTGCGAGGA
GGACCCGGTGACCGGCAGTGTGGGCACCCAGGGCCGCGCCTGCAACAAGACGGCTCCCCAGGCCAGCGGCTGTGACCTCATGTGCTGTGG
GCGTGGCTACAACACCCACCAGTACGCCCGCGTGTGGCAGTGCAACTGTAAGTTCCACTGGTGCTGCTATGTCAAGTGCAACACGTGCAG
CGAGCGCACGGAGATGTACACGTGCAAGTGAGCCCCGTGTGCACACCACCCTCCCGCTGCAAGTCAGATTGCTGGGAGGACTGGACCGTT
TCCAAGCTGCGGGCTCCCTGGCAGGATGCTGAGCTTGTCTTTTCTGCTGAGGAGGGTACTTTTCCTGGGTTTCCTGCAGGCATCCGTGGG
GGAAAAAAAATCTCTCAGAGCCCTCAACTATTCTGTTCCACACCCAATGCTGCTCCACCCTCCCCCAGACACAGCCCAGGTCCCTCCGCG
GCTGGAGCGAAGCCTTCTGCAGCAGGAACTCTGGACCCCTGGGCCTCATCACAGCAATATTTAACAATTTATTCTGATAAAAATAATATT
AATTTATTTAATTAAAAAGAATTCTTCCACCTCGTCGGGATCCGTTTTCTGCAATCAAAGTGGACTGCTTGCTTTCCTAGCAGGATGATT
TTGTTGCTAGGACAAGGAGCCGTGTAGAAGTGTACATAACTATTCTTTATGCAGATATTTCTACTAGCTGATTTTGCAGGTACCCACCTT
GCAGCACTAGATGTTTAAGTACAAGAGGAGACATCTTTTATGCATATATAGATATACACACACACATTTTTTTTTTTTTTTTTGCTGTTT
GCTGCTACTTATCCAGAAATTTAAGCTGGTCCAGATTTGGAGACGTTTTTTCCAGAGTATGTTTTCCATCCTTTTGCCCTCCCCAGTTCA
AACTTCACCATTAGAAAAATCCAGTTTGGAATAAATAGAGAGGAAAAATAATAAATTCCCAGCAGTTTCCATCTTTCGGAAAGTGAGCCA
CCGGATAAGAGAGAATATTTTGTAAGAGACTATTTTTATATGAATATTTTATTTATATCGAGTCTACTGTATCATTCCACGGCCTGTGCT
TCTTCTTAATTCTGGTACTCACTTAGGGGTAAGGAGGGGCGATGCCTGGTTGTGGCGTCAGGCCCCATGGGGCCCCTTGCACAGCTGGAT
TCTTGAGTTCTGTTTGCCAAGTGGGCACAAGCTGCCCCTGGATGCCTGGGGTTGAGGCATCATCTCATCCATGTTAGCCGGGAAAGAAAT
CAAATCCCCAGCCTCAGCCTGTTAAGCTCAGGCCTTTCAAGCAGGGCCACTGAGTGGTAGCTTCGAAATGAGTCACTGTGGTGGGTGGTC
ATCGTGCCCCTCACAGGGACTTGACCGTCATCCTGCAGCAGAGGCCAGTTCAGGGAGCCCCACACCTCACCAAGACACTAGCCATTGCCT
GCGTGTCCTGGAAGGTGAGATGTAGTCCTCAGGTGAGGTGACCCAAAGCAGATGGGGTGAGGGGCCGATGAGCAGCCGGGCCCAGCGGGG
CTTCCTGGATATCCTGCTCCCAAGGCCAAGCAGCAGAGAGAGGTTCAAGTGAGGCCACTTTGCTTTGGGTCCAGCTACACCCAGAGCCTC
AGCCTAGAAAGCTGTCCTCCAGCAGGCTGGGGGTGTTCTAATATGTGTCCGTTTGCATTTCCGGTGTGTGTGTGTGTGTGTGTGTGTGTG
TGTGTGTGTGTGTGTGTGTGTACTGTATCTTCTTAGGGACTTGAGTGTAGTCACGTGACTTTGCGCCTTGCAGCGCCTCCGCCGTACTCG
TGTGTGTATGTGTCTGTGTGTTTCCGTGCTACCCAAGCGTCTGTTTCTCTCCGTGTGCCTGGGAGATCAGGTCTCAGGCATGGAGCTGCA
TGCCTTTGCATCTGCTGCTCCCCAGAGTCTCTGCTTGCATGTGAGGGCTGGTGGTATGAGGCAGACAGCAGAGATTGTGTGTGATTGTGT
TGAACCGCCAAGAGAAGGCACCTCTGAACTCTGTCCCCACACCCATGGGTGAAAACCAGACACCTCTGAGACCACAGCACAGCCCCATGG
CCCCACCTGCTGGGAGCCCTTCAGTATCTAGGCTGTGTCTGACTCCTCAGTGTCCACACTGAGCCTGGATCACAGCATGGGCAAATAAAA
GTGACTGGATGGTTGCATGGTTTCTTCCCTTGGACATTTTTTTCCATTTTTCTTTTACTTGGGTGTCTGGAGGAGTGGGCATGTGAAGGG
GCCATGGAGTGAATGGATGGAGGGATGGATGAATGTGTGAGTAGGTAGGTAGGTGAATGGGTAGATGTGTGGATGGATAAGTAGGTGGGT
GGGTGAATGGATAAATGGATGGATGGGTAGATGGATGGATGAAGGGATAAACAGATGGGTGGATGGATTGATAAGTGAGCGGATGAATGG
ATGAATAGCTAGGAAAGTGGGTGGGTGGATGAGGGTGGGTTGATGAGGTAGGTACACCTACAGATAGGTAAGTGAGCAGTTTCTTGGGAG
TCCACAGGTCACATTTTATCTTTGCTTTGGAAAACCTAGCAGATCTGCCATGATCAGGATGGCTTCCCGACCTTGCAACCCTTCTGCTTC
TGACCTCCTTGGCACCTGGGAATGGGGGAGATTCTGACCAGCCTCCCCAGATGAGTGTTCAATGATAGTTACATAAACACAGTCTCAGAA
GAGTCATCCCTGTGTCCTCCCTCACTGTGGGTTCCCAGCTCTGGGGCCTGCCCTCTCTCGGGTGCCCTGTTCAGCTGTGCTCTGAGCCCC
AGTTTCTCCACCTGTGAAATCAGAATAACACCTACCTCACAGGGCTGTTGTGAGGATCCTCCCAGTAATGACTGTATGGCACTTTGAGTT

>40196_40196_2_IQSEC1-WNT7A_IQSEC1_chr3_12963620_ENST00000273221_WNT7A_chr3_13916670_ENST00000285018_length(amino acids)=957AA_BP=631
MWCLHCNSERTQSLLELELDSGVEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPGQQQRTRRPKLQHSTSI
LRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFS
FEGPEKVHSSYFEGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPA
LDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCR
STPSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSHLA
INGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPE
KGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEA
FSGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIA
AGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKC
HGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for IQSEC1-WNT7A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for IQSEC1-WNT7A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for IQSEC1-WNT7A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	IQSEC1	C0013336	Dwarfism	1	GENOMICS_ENGLAND
Hgene	IQSEC1	C0024121	Lung Neoplasms	1	CTD_human
Hgene	IQSEC1	C0233514	Abnormal behavior	1	GENOMICS_ENGLAND
Hgene	IQSEC1	C0242379	Malignant neoplasm of lung	1	CTD_human
Hgene	IQSEC1	C0349588	Short stature	1	GENOMICS_ENGLAND
Hgene	IQSEC1	C0557874	Global developmental delay	1	GENOMICS_ENGLAND
Hgene	IQSEC1	C1842364	Central hypotonia	1	GENOMICS_ENGLAND
Hgene	IQSEC1	C2919142	Short Stature, CTCAE	1	GENOMICS_ENGLAND
Hgene	IQSEC1	C3714756	Intellectual Disability	1	GENOMICS_ENGLAND
Tgene		C1848651	Al Awadi syndrome	7	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C1856728	Fuhrmann syndrome	4	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C0042065	Genitourinary Neoplasms	1	CTD_human
Tgene		C0751569	Genitourinary Cancer	1	CTD_human
Tgene		C0919267	ovarian neoplasm	1	CTD_human
Tgene		C1140680	Malignant neoplasm of ovary	1	CTD_human
Tgene		C1720887	Female Urogenital Diseases	1	CTD_human
Tgene		C1862939	AMYOTROPHIC LATERAL SCLEROSIS 1	1	CTD_human
Tgene		C1862941	Amyotrophic Lateral Sclerosis, Sporadic	1	CTD_human
Tgene		C4551993	Amyotrophic Lateral Sclerosis, Familial	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:IQSEC1-WNT7A (FusionGDB2 ID:HG9922TG7476)

Fusion Gene Summary for IQSEC1-WNT7A

Fusion Gene ORF analysis for IQSEC1-WNT7A

Fusion Genomic Features for IQSEC1-WNT7A

Fusion Protein Features for IQSEC1-WNT7A

Fusion Gene Sequence for IQSEC1-WNT7A

Fusion Gene PPI Analysis for IQSEC1-WNT7A

Related Drugs for IQSEC1-WNT7A

Related Diseases for IQSEC1-WNT7A

Fusion Gene Studies
in Kim Lab