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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDC27-ST7L (FusionGDB2 ID:HG996TG54879)

Fusion Gene Summary for CDC27-ST7L

check button Fusion gene summary
Fusion gene informationFusion gene name: CDC27-ST7L
Fusion gene ID: hg996tg54879
HgeneTgene
Gene symbol

CDC27

ST7L

Gene ID

996

54879

Gene namecell division cycle 27suppression of tumorigenicity 7 like
SynonymsANAPC3|APC3|CDC27Hs|D0S1430E|D17S978E|H-NUC|HNUC|NUC2FAM4B|ST7R|STLR
Cytomap('CDC27')('ST7L')

17q21.32

1p13.2

Type of geneprotein-codingprotein-coding
Descriptioncell division cycle protein 27 homologD0S1430E, D17S978Eanaphase promoting complex subunit 3anaphase-promoting complex, protein 3cell division cycle 27 homolognuc2 homologsuppressor of tumorigenicity 7 protein-likeST7-related proteintumor suppressor ST7 like
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000066544, ENST00000527547, 
ENST00000531206, ENST00000446365, 
ENST00000528748, 
Fusion gene scores* DoF score12 X 8 X 10=9608 X 10 X 3=240
# samples 1610
** MAII scorelog2(16/960*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/240*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDC27 [Title/Abstract] AND ST7L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDC27(45266512)-ST7L(113143470), # samples:3
Anticipated loss of major functional domain due to fusion event.CDC27-ST7L seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDC27

GO:0070979

protein K11-linked ubiquitination

18485873



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A1-A0SH-01ACDC27chr17

45266512

-ST7Lchr1

113143470

-
ChimerDB4BRCATCGA-A1-A0SHCDC27chr17

45266511

-ST7Lchr1

113143470

-


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Fusion Gene ORF analysis for CDC27-ST7L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000066544ENST00000463235CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-5UTRENST00000066544ENST00000463235CDC27chr17

45266511

-ST7Lchr1

113143470

-
5CDS-5UTRENST00000066544ENST00000543570CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-5UTRENST00000066544ENST00000543570CDC27chr17

45266511

-ST7Lchr1

113143470

-
5CDS-5UTRENST00000527547ENST00000463235CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-5UTRENST00000527547ENST00000463235CDC27chr17

45266511

-ST7Lchr1

113143470

-
5CDS-5UTRENST00000527547ENST00000543570CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-5UTRENST00000527547ENST00000543570CDC27chr17

45266511

-ST7Lchr1

113143470

-
5CDS-5UTRENST00000531206ENST00000463235CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-5UTRENST00000531206ENST00000463235CDC27chr17

45266511

-ST7Lchr1

113143470

-
5CDS-5UTRENST00000531206ENST00000543570CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-5UTRENST00000531206ENST00000543570CDC27chr17

45266511

-ST7Lchr1

113143470

-
5CDS-intronENST00000066544ENST00000343210CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-intronENST00000066544ENST00000343210CDC27chr17

45266511

-ST7Lchr1

113143470

-
5CDS-intronENST00000066544ENST00000369666CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-intronENST00000066544ENST00000369666CDC27chr17

45266511

-ST7Lchr1

113143470

-
5CDS-intronENST00000066544ENST00000369668CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-intronENST00000066544ENST00000369668CDC27chr17

45266511

-ST7Lchr1

113143470

-
5CDS-intronENST00000066544ENST00000369669CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-intronENST00000066544ENST00000369669CDC27chr17

45266511

-ST7Lchr1

113143470

-
5CDS-intronENST00000066544ENST00000490067CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-intronENST00000066544ENST00000490067CDC27chr17

45266511

-ST7Lchr1

113143470

-
5CDS-intronENST00000066544ENST00000538187CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-intronENST00000066544ENST00000538187CDC27chr17

45266511

-ST7Lchr1

113143470

-
5CDS-intronENST00000527547ENST00000343210CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-intronENST00000527547ENST00000343210CDC27chr17

45266511

-ST7Lchr1

113143470

-
5CDS-intronENST00000527547ENST00000369666CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-intronENST00000527547ENST00000369666CDC27chr17

45266511

-ST7Lchr1

113143470

-
5CDS-intronENST00000527547ENST00000369668CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-intronENST00000527547ENST00000369668CDC27chr17

45266511

-ST7Lchr1

113143470

-
5CDS-intronENST00000527547ENST00000369669CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-intronENST00000527547ENST00000369669CDC27chr17

45266511

-ST7Lchr1

113143470

-
5CDS-intronENST00000527547ENST00000490067CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-intronENST00000527547ENST00000490067CDC27chr17

45266511

-ST7Lchr1

113143470

-
5CDS-intronENST00000527547ENST00000538187CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-intronENST00000527547ENST00000538187CDC27chr17

45266511

-ST7Lchr1

113143470

-
5CDS-intronENST00000531206ENST00000343210CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-intronENST00000531206ENST00000343210CDC27chr17

45266511

-ST7Lchr1

113143470

-
5CDS-intronENST00000531206ENST00000369666CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-intronENST00000531206ENST00000369666CDC27chr17

45266511

-ST7Lchr1

113143470

-
5CDS-intronENST00000531206ENST00000369668CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-intronENST00000531206ENST00000369668CDC27chr17

45266511

-ST7Lchr1

113143470

-
5CDS-intronENST00000531206ENST00000369669CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-intronENST00000531206ENST00000369669CDC27chr17

45266511

-ST7Lchr1

113143470

-
5CDS-intronENST00000531206ENST00000490067CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-intronENST00000531206ENST00000490067CDC27chr17

45266511

-ST7Lchr1

113143470

-
5CDS-intronENST00000531206ENST00000538187CDC27chr17

45266512

-ST7Lchr1

113143470

-
5CDS-intronENST00000531206ENST00000538187CDC27chr17

45266511

-ST7Lchr1

113143470

-
5UTR-3CDSENST00000446365ENST00000358039CDC27chr17

45266512

-ST7Lchr1

113143470

-
5UTR-3CDSENST00000446365ENST00000358039CDC27chr17

45266511

-ST7Lchr1

113143470

-
5UTR-3CDSENST00000446365ENST00000360743CDC27chr17

45266512

-ST7Lchr1

113143470

-
5UTR-3CDSENST00000446365ENST00000360743CDC27chr17

45266511

-ST7Lchr1

113143470

-
5UTR-3CDSENST00000446365ENST00000544629CDC27chr17

45266512

-ST7Lchr1

113143470

-
5UTR-3CDSENST00000446365ENST00000544629CDC27chr17

45266511

-ST7Lchr1

113143470

-
5UTR-5UTRENST00000446365ENST00000463235CDC27chr17

45266512

-ST7Lchr1

113143470

-
5UTR-5UTRENST00000446365ENST00000463235CDC27chr17

45266511

-ST7Lchr1

113143470

-
5UTR-5UTRENST00000446365ENST00000543570CDC27chr17

45266512

-ST7Lchr1

113143470

-
5UTR-5UTRENST00000446365ENST00000543570CDC27chr17

45266511

-ST7Lchr1

113143470

-
5UTR-intronENST00000446365ENST00000343210CDC27chr17

45266512

-ST7Lchr1

113143470

-
5UTR-intronENST00000446365ENST00000343210CDC27chr17

45266511

-ST7Lchr1

113143470

-
5UTR-intronENST00000446365ENST00000369666CDC27chr17

45266512

-ST7Lchr1

113143470

-
5UTR-intronENST00000446365ENST00000369666CDC27chr17

45266511

-ST7Lchr1

113143470

-
5UTR-intronENST00000446365ENST00000369668CDC27chr17

45266512

-ST7Lchr1

113143470

-
5UTR-intronENST00000446365ENST00000369668CDC27chr17

45266511

-ST7Lchr1

113143470

-
5UTR-intronENST00000446365ENST00000369669CDC27chr17

45266512

-ST7Lchr1

113143470

-
5UTR-intronENST00000446365ENST00000369669CDC27chr17

45266511

-ST7Lchr1

113143470

-
5UTR-intronENST00000446365ENST00000490067CDC27chr17

45266512

-ST7Lchr1

113143470

-
5UTR-intronENST00000446365ENST00000490067CDC27chr17

45266511

-ST7Lchr1

113143470

-
5UTR-intronENST00000446365ENST00000538187CDC27chr17

45266512

-ST7Lchr1

113143470

-
5UTR-intronENST00000446365ENST00000538187CDC27chr17

45266511

-ST7Lchr1

113143470

-
Frame-shiftENST00000066544ENST00000358039CDC27chr17

45266512

-ST7Lchr1

113143470

-
Frame-shiftENST00000066544ENST00000358039CDC27chr17

45266511

-ST7Lchr1

113143470

-
Frame-shiftENST00000066544ENST00000360743CDC27chr17

45266512

-ST7Lchr1

113143470

-
Frame-shiftENST00000066544ENST00000360743CDC27chr17

45266511

-ST7Lchr1

113143470

-
Frame-shiftENST00000066544ENST00000544629CDC27chr17

45266512

-ST7Lchr1

113143470

-
Frame-shiftENST00000066544ENST00000544629CDC27chr17

45266511

-ST7Lchr1

113143470

-
Frame-shiftENST00000527547ENST00000358039CDC27chr17

45266512

-ST7Lchr1

113143470

-
Frame-shiftENST00000527547ENST00000358039CDC27chr17

45266511

-ST7Lchr1

113143470

-
Frame-shiftENST00000527547ENST00000360743CDC27chr17

45266512

-ST7Lchr1

113143470

-
Frame-shiftENST00000527547ENST00000360743CDC27chr17

45266511

-ST7Lchr1

113143470

-
Frame-shiftENST00000527547ENST00000544629CDC27chr17

45266512

-ST7Lchr1

113143470

-
Frame-shiftENST00000527547ENST00000544629CDC27chr17

45266511

-ST7Lchr1

113143470

-
Frame-shiftENST00000531206ENST00000358039CDC27chr17

45266512

-ST7Lchr1

113143470

-
Frame-shiftENST00000531206ENST00000358039CDC27chr17

45266511

-ST7Lchr1

113143470

-
Frame-shiftENST00000531206ENST00000360743CDC27chr17

45266512

-ST7Lchr1

113143470

-
Frame-shiftENST00000531206ENST00000360743CDC27chr17

45266511

-ST7Lchr1

113143470

-
Frame-shiftENST00000531206ENST00000544629CDC27chr17

45266512

-ST7Lchr1

113143470

-
Frame-shiftENST00000531206ENST00000544629CDC27chr17

45266511

-ST7Lchr1

113143470

-
intron-3CDSENST00000528748ENST00000358039CDC27chr17

45266512

-ST7Lchr1

113143470

-
intron-3CDSENST00000528748ENST00000358039CDC27chr17

45266511

-ST7Lchr1

113143470

-
intron-3CDSENST00000528748ENST00000360743CDC27chr17

45266512

-ST7Lchr1

113143470

-
intron-3CDSENST00000528748ENST00000360743CDC27chr17

45266511

-ST7Lchr1

113143470

-
intron-3CDSENST00000528748ENST00000544629CDC27chr17

45266512

-ST7Lchr1

113143470

-
intron-3CDSENST00000528748ENST00000544629CDC27chr17

45266511

-ST7Lchr1

113143470

-
intron-5UTRENST00000528748ENST00000463235CDC27chr17

45266512

-ST7Lchr1

113143470

-
intron-5UTRENST00000528748ENST00000463235CDC27chr17

45266511

-ST7Lchr1

113143470

-
intron-5UTRENST00000528748ENST00000543570CDC27chr17

45266512

-ST7Lchr1

113143470

-
intron-5UTRENST00000528748ENST00000543570CDC27chr17

45266511

-ST7Lchr1

113143470

-
intron-intronENST00000528748ENST00000343210CDC27chr17

45266512

-ST7Lchr1

113143470

-
intron-intronENST00000528748ENST00000343210CDC27chr17

45266511

-ST7Lchr1

113143470

-
intron-intronENST00000528748ENST00000369666CDC27chr17

45266512

-ST7Lchr1

113143470

-
intron-intronENST00000528748ENST00000369666CDC27chr17

45266511

-ST7Lchr1

113143470

-
intron-intronENST00000528748ENST00000369668CDC27chr17

45266512

-ST7Lchr1

113143470

-
intron-intronENST00000528748ENST00000369668CDC27chr17

45266511

-ST7Lchr1

113143470

-
intron-intronENST00000528748ENST00000369669CDC27chr17

45266512

-ST7Lchr1

113143470

-
intron-intronENST00000528748ENST00000369669CDC27chr17

45266511

-ST7Lchr1

113143470

-
intron-intronENST00000528748ENST00000490067CDC27chr17

45266512

-ST7Lchr1

113143470

-
intron-intronENST00000528748ENST00000490067CDC27chr17

45266511

-ST7Lchr1

113143470

-
intron-intronENST00000528748ENST00000538187CDC27chr17

45266512

-ST7Lchr1

113143470

-
intron-intronENST00000528748ENST00000538187CDC27chr17

45266511

-ST7Lchr1

113143470

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CDC27-ST7L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for CDC27-ST7L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:45266512/:113143470)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CDC27-ST7L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CDC27-ST7L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDC27-ST7L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDC27-ST7L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDC27C0033578Prostatic Neoplasms1CTD_human
HgeneCDC27C0376358Malignant neoplasm of prostate1CTD_human