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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:DGCR2-PPPDE2 (FusionGDB2 ID:HG9993TG27351) |
Fusion Gene Summary for DGCR2-PPPDE2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DGCR2-PPPDE2 | Fusion gene ID: hg9993tg27351 | Hgene | Tgene | Gene symbol | DGCR2 | PPPDE2 | Gene ID | 9993 | 27351 |
| Gene name | DiGeorge syndrome critical region gene 2 | desumoylating isopeptidase 1 | |
| Synonyms | DGS-C|IDD|LAN|SEZ-12 | D15Wsu75e|DESI2|DJ347H13.4|DeSI-1|FAM152B|POST|PPPDE2 | |
| Cytomap | ('DGCR2','DGCR2')('DESI1','PPPDE2') 22q11.21 | 22q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | integral membrane protein DGCR2/IDDDiGeorge syndrome critical region protein 2integral membrane protein deleted in DiGeorge syndrome | desumoylating isopeptidase 1PPPDE peptidase domain containing 2PPPDE peptidase domain-containing protein 2desumoylating isopeptidase 2family with sequence similarity 152, member Bpolyubiquitinated substrate transporter | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000545799, ENST00000263196, ENST00000537045, ENST00000473832, | ||
| Fusion gene scores | * DoF score | 16 X 15 X 8=1920 | 5 X 3 X 3=45 |
| # samples | 21 | 5 | |
| ** MAII score | log2(21/1920*10)=-3.1926450779424 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DGCR2 [Title/Abstract] AND PPPDE2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DGCR2(19028571)-DESI1(42003865), # samples:2 DGCR2(19028570)-PPPDE2(42003865), # samples:1 DGCR2(19028571)-PPPDE2(42003865), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | DGCR2-DESI1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DGCR2-DESI1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DGCR2-DESI1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DGCR2-DESI1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across DGCR2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across PPPDE2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-BH-A0EE-01A | DGCR2 | chr22 | 19028571 | - | DESI1 | chr22 | 42003865 | - |
| ChimerDB4 | BRCA | TCGA-BH-A0EE-01A | DGCR2 | chr22 | 19028571 | - | PPPDE2 | chr22 | 42003865 | - |
| ChimerDB4 | BRCA | TCGA-BH-A0EE | DGCR2 | chr22 | 19028570 | - | PPPDE2 | chr22 | 42003865 | - |
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Fusion Gene ORF analysis for DGCR2-PPPDE2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000545799 | ENST00000263256 | DGCR2 | chr22 | 19028571 | - | DESI1 | chr22 | 42003865 | - |
| 3UTR-intron | ENST00000545799 | ENST00000463886 | DGCR2 | chr22 | 19028571 | - | DESI1 | chr22 | 42003865 | - |
| 5CDS-intron | ENST00000263196 | ENST00000463886 | DGCR2 | chr22 | 19028571 | - | DESI1 | chr22 | 42003865 | - |
| 5CDS-intron | ENST00000537045 | ENST00000463886 | DGCR2 | chr22 | 19028571 | - | DESI1 | chr22 | 42003865 | - |
| In-frame | ENST00000263196 | ENST00000263256 | DGCR2 | chr22 | 19028571 | - | DESI1 | chr22 | 42003865 | - |
| In-frame | ENST00000537045 | ENST00000263256 | DGCR2 | chr22 | 19028571 | - | DESI1 | chr22 | 42003865 | - |
| intron-3CDS | ENST00000473832 | ENST00000263256 | DGCR2 | chr22 | 19028571 | - | DESI1 | chr22 | 42003865 | - |
| intron-intron | ENST00000473832 | ENST00000463886 | DGCR2 | chr22 | 19028571 | - | DESI1 | chr22 | 42003865 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000537045 | DGCR2 | chr22 | 19028571 | - | ENST00000263256 | DESI1 | chr22 | 42003865 | - | 5009 | 1521 | 248 | 1939 | 563 |
| ENST00000263196 | DGCR2 | chr22 | 19028571 | - | ENST00000263256 | DESI1 | chr22 | 42003865 | - | 5132 | 1644 | 248 | 2062 | 604 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000537045 | ENST00000263256 | DGCR2 | chr22 | 19028571 | - | DESI1 | chr22 | 42003865 | - | 0.004989868 | 0.99501014 |
| ENST00000263196 | ENST00000263256 | DGCR2 | chr22 | 19028571 | - | DESI1 | chr22 | 42003865 | - | 0.004450802 | 0.9955492 |
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Fusion Genomic Features for DGCR2-PPPDE2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for DGCR2-PPPDE2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:19028571/:42003865) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000263196 | - | 9 | 10 | 115_241 | 465 | 551.0 | Domain | C-type lectin |
| Hgene | DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000263196 | - | 9 | 10 | 270_333 | 465 | 551.0 | Domain | Note=VWFC |
| Hgene | DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000263196 | - | 9 | 10 | 28_68 | 465 | 551.0 | Domain | LDL-receptor class A |
| Hgene | DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000537045 | - | 8 | 9 | 115_241 | 424 | 510.0 | Domain | C-type lectin |
| Hgene | DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000537045 | - | 8 | 9 | 270_333 | 424 | 510.0 | Domain | Note=VWFC |
| Hgene | DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000537045 | - | 8 | 9 | 28_68 | 424 | 510.0 | Domain | LDL-receptor class A |
| Hgene | DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000263196 | - | 9 | 10 | 21_349 | 465 | 551.0 | Topological domain | Extracellular |
| Hgene | DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000537045 | - | 8 | 9 | 21_349 | 424 | 510.0 | Topological domain | Extracellular |
| Hgene | DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000263196 | - | 9 | 10 | 350_368 | 465 | 551.0 | Transmembrane | Helical |
| Hgene | DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000537045 | - | 8 | 9 | 350_368 | 424 | 510.0 | Transmembrane | Helical |
| Tgene | DESI1 | chr22:19028571 | chr22:42003865 | ENST00000263256 | 0 | 6 | 139_153 | 29 | 169.0 | Motif | Nuclear export signal 2 | |
| Tgene | DESI1 | chr22:19028571 | chr22:42003865 | ENST00000263256 | 0 | 6 | 83_91 | 29 | 169.0 | Motif | Nuclear export signal 1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000263196 | - | 9 | 10 | 369_550 | 465 | 551.0 | Topological domain | Cytoplasmic |
| Hgene | DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000537045 | - | 8 | 9 | 369_550 | 424 | 510.0 | Topological domain | Cytoplasmic |
| Tgene | DESI1 | chr22:19028571 | chr22:42003865 | ENST00000263256 | 0 | 6 | 7_149 | 29 | 169.0 | Domain | PPPDE |
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Fusion Gene Sequence for DGCR2-PPPDE2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >22402_22402_1_DGCR2-DESI1_DGCR2_chr22_19028571_ENST00000263196_DESI1_chr22_42003865_ENST00000263256_length(transcript)=5132nt_BP=1644nt GGGGCGGGGCGGCGCGGCGCGGAGCCGAGCAGGACGGCCGCCATCTTGCGCGCAGCTGGAGTCGGTGCCTGAGGTTGCAGCCGAGAGTGT GCGCCAGCCCGCGGCCCAGCCGAAGCTCTTTCCCGCCGCCTCTCCGCGCCTCGCCCAGGTTCAGCTCCGCCTGACCCTCCGCTTGGCACG GTCCCCTGACCCTCAGTCCGGCCTGGTCCGGCCTTCCAGCCGCCCCGGGGACGATGAACGGAGGATAAATGGTGCCCAAGGCAGACAGCG GCGCCTTCCTGCTGCTCTTCCTGCTCGTGCTCACTGTCACCGAGCCGCTGCGGCCAGAGCTGCGGTGCAACCCTGGGCAGTTTGCGTGTC GCAGCGGCACCATCCAGTGCATCCCCCTCCCCTGGCAGTGTGACGGCTGGGCGACTTGCGAGGATGAGAGCGACGAAGCCAACTGTCCAG AAGTGACCGGGGAGGTGCGTCCTCATCATGGGAAGGAGGCTGTGGATCCGCGGCAGGGGCGGGCCAGAGGAGGCGACCCTTCGCACTTCC ACGCGGTGAACGTGGCGCAGCCCGTTCGCTTCAGCAGTTTCCTAGGGAAGTGCCCGACAGGGTGGCACCACTACGAAGGCACGGCCAGCT GCTACCGGGTCTACCTGAGCGGGGAGAACTACTGGGATGCCGCGCAGACCTGCCAGCGCCTGAATGGCTCTCTCGCCACCTTCTCCACTG ACCAGGAGCTGCGCTTTGTCCTGGCCCAGGAATGGGACCAGCCCGAGCGGAGCTTTGGTTGGAAGGACCAGCGCAAGTTGTGGGTTGGCT ATCAGTATGTTATCACTGGCCGGAACCGCTCCTTGGAAGGTCGCTGGGAGGTGGCATTCAAAGGCTCTTCAGAGGTGTTCCTGCCCCCAG ACCCCATCTTTGCCTCGGCCATGTCTGAGAACGACAACGTGTTCTGTGCCCAGCTTCAGTGCTTCCATTTCCCCACCCTGCGGCACCACG ACCTCCACAGCTGGCACGCCGAGAGCTGCTACGAGAAGTCTTCATTTCTGTGTAAAAGAAGTCAAACATGTGTTGACATCAAGGACAACG TGGTGGATGAAGGGTTCTACTTCACCCCTAAGGGGGACGACCCATGCCTGAGCTGCACCTGCCATGGAGGGGAGCCTGAGATGTGTGTGG CTGCTCTCTGTGAGAGGCCCCAGGGCTGCCAACAGTACCGCAAGGACCCCAAAGAGTGCTGCAAGTTCATGTGTCTGGACCCAGATGGCA ACAGTCTGTTTGACTCCATGGCCAGCGGGATGCGCCTGGTCGTCAGCTGCATCTCCTCCTTCCTCATCCTGTCACTGCTGCTCTTCATGG TCCACCGGCTGCGCCAGCGGCGCCGGGAGCGCATCGAGTCCCTGATTGGAGCAAACTTGCACCACTTCAACCTCGGCCGCAGGATCCCTG GCTTTGATTACGGCCCAGACGGGTTTGGCACGGGCCTCACGCCGCTGCATCTTTCTGACGACGGAGAGGGTGGGACTTTCCATTTCCACG ACCCTCCACCTCCCTACACGGCATACAAGTACCCGGACATCGGCCAGCCCGACGACCCTCCGCCGCCCTACGAGGCCTCCATCCACCCGG ACAGTGTGTTCTATGACCCTGCAGGGAAACAACTGGAAGGCATCTGGCACACATCCATAGTTGTGCACAAGGATGAGTTCTTCTTCGGCA GTGGTGGTATCTCCAGCTGCCCCCCGGGAGGGACATTGCTTGGGCCTCCAGACTCTGTGGTTGATGTGGGGAGTACAGAAGTCACAGAAG AAATCTTTCTGGAGTACCTCTCCTCCCTGGGGGAGTCCCTGTTCCGAGGTGAGGCCTACAACCTCTTTGAACACAATTGTAACACCTTCA GCAACGAAGTGGCACAGTTCCTGACTGGGCGGAAGATTCCTTCTTACATCACAGACCTGCCCTCTGAAGTTCTCTCCACGCCCTTTGGAC AGGCACTTCGGCCCCTCCTGGACTCCATTCAGATCCAGCCTCCAGGAGGGAGCTCCGTGGGCAGACCCAACGGCCAGAGCTAACAGGACT GCCTGGGACCGCCCTGCCTCACCAGGGCTTTTCCTTTTTAAACAAAACAAACCCTACCAGATTTCTATTTTATAATTTTACATCAGAGCT AACAACCAGGGGACGGCTTTTTAAATTTCCCAGGGAAGGAGACCGTCAGGCCGCATGTAGACAATGCTGCTAAGAAACAGAACAAAATGC CACCCCTTCTAATAGTATTATACTAATTTATTAAGGCTGTCTTGTCTGTGCGTTCACTTCGGATGCTGTTTCCTAAGCGTCCTCCACACT GGAGAAAGGGAGGGGCTTTGTTTAAACAGAAAGCGAGTCACAGTTTGCGGGAGCCCCAACCTAGAACTCTTTCCAGAGAACACTCACGCT CTACCCAAGTTGCCAACACCTGTGGGACCCAGGTGAGTTTTAGAACATCCGTGACCCAGAAAGTTACTCTAGTGTTAAATGAACCAAAGG ATTTGGTGTACATGGGACCGGTTTCAGGATGACTAACCTAACCTAAGTGAACTCTTTAGCCACAACCCTCACCTTCCCTCCCTTACCCCA AGCAAGGCCAGTGCTGGAGCAGCCATTGCCTCCGGATCAAGGGAGTAACAGCAAGTATCAGGCCGGAGAAAACAGGATAAAGCCATTCCT CCTTCCACCTAGATGGATTGCCAATCTTCTGCCATCAATTTTGGGAAACCTGCCTTTGTGCCCCCGAGGCTGCCTTTCCTCAGCATAGCT GACTTGTCATAGTGGATGAGGTCTGGGCTGGAGCAGTAGAAGCCAAGGCCTTTTTTCTGCAAGTAATGATGTAGGTTATTTGCAGTCTCT GTAACCACCATCCAGGCCAGTACGCAGTATTTAGCTGGGGACCAAGGGATGGGATTCCCTACTCTAAGAAAATACCTTTATTTTAATTAT TATTATTTTTTGAGACGGAGTCTCGCTCTACCACCCAGGCTGGTGTGCAGTGGCATGATCTCGGCTCACAGAAACCTCTGCCTCCCGGGT TCAAGTGGTTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCGTGCCACCACGCCAGGCTAATTTTTGTATTTTCAGTAGAG ACAGGGTTTTGCCATGTTGGCCAGGCTGGTCTGGAACTCCTGACCTCGGGTGATCCACCTCCCTTGGCCTCCCAAAGTGCTGGGATTACA GGCGTGAGCCACCGCTGCCTGGCCAGAAAATACCTTTGATATGGAAAGAATAATGATGTGAGGCCTGGCGCGGTGGCTCACGCCTGTAAT CCCAGCACTTTGGGAGGCCGAGGCAGGCAGATCACTTGAGGTCAGGACTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTAC TAAAAATACAAAATTAGCCGGGCATGGTGGCGCATGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGG AGGCAGAGATTGCGATGAGCCGAGATCGTACCAGTGCACTCCAGCCTGGGCGACAGAGTGAGACTCCATCTCAAAAAAATAAAATAATGA AGTGGAATCAAGGTGGCAAGAAAATTTAGAATCGTTTCTGATAGGGACTTTCCCTTATCCTAAATGTGTTTTGAAGGCACACGTTATTTC CATTGTCATTCTGACTTTAGAAAGGCAGGTTGGGGCATGAGTGGGCATTTTCCTAATGACTTGCTGCTAGGAGGTTATAGGCAGGGAACA GTCTGGGAGTCTCTAATCCAGAGAGACTTTCAGATTCCCTCTCTTCACATGAACCTCCATTAGTTAGATTTTGGGAAAGTGAGCATGAAG AAGGGACTCAGAGCTGCCAGGTACCCGAGTCTCAGGTCTGACATCCTTGGGCCCCTTCTGCCACAACTTCTTGCCACTTCACGGACTTGA ATTATGTTGCTTCTTCCTGGAAGTCTGGCCTGCAGCACAGGCCTTTCCTCTCCAAAAAGCTGCTGCTCATTTCTGGCCCCATCTGCTGCT ATCTTTGCCATCAGCCATCACAGTTTGGCATCATCAGAGTCTCAGCTAGAGGAGCTGTCATTCTGCCTTAGTGTTTGCCTGCGACCTGAC CAGGGGCATGACCAGCTGGGATGTCAAGTGACATTTGGGAACTTGTAGAGGCCAAATGATTGAAAGTTTAATTCTTCTCAAGACCCACTG ATTTGCCAGTGTGCATGGAAATAATAGATTAGAGCAGAAACTAGCAGGGACTGTTGTATAATCGTGATCTACTAGCAGAATTGGGCCCAA AGAGAAAGAATTTCTGAGGCTGGGTTTCTTCTGGGAGGGTAGCAGGTTGGTCTTGGCCAGTGCTCTGTTTCCCACCAGTGTTGTTCCCTT TTCCAGCTTGCCTGGCCCGGCTCTGTCTTCCAGGGTCCTGCTCCAGACCCCTCTGCCTGGGGTCTCCCCTCCATCCAGGGGGTTCTGGGC ATCACAGCTCCTTTTTTTCCTTTCTCCTCTTCCAGATCCAGTTTCAGCTGGTTTGCTTCTTCCAGCAGGCACCCTTAGGCCCAGGAGCAG CTCCCCTGAGAGAATTTGAGTCACTCATTTCCTTGAACAGCACCCCCCTTTATACTAGCAGCCATTTGTGCCATTGCCTGTGCCCTAGGG TTTGTGGGGAGAGAGCGAGGGATCACTGAGCAGTTTTCCCAGAGCTCCATGGGAAGGCAAGCTCTCCCTCCCAATGGGAGCCCCACTGTC ACTAACTGTAAACTCAGGCTCAGGCTTCAACTGCCTACCCCCATCCTCATATTTCTGTCTGTCCCAGCACCTCAGGAGCATTCTCATTGT GGCCGGCTAACTCCGCCTGGATGTGAACAGGCAAGCACAGTGGGAAATGAGTCACGTACTTGTATTGCACAGTGGACACCTCTAGAGGTC CATTGGTTTAAAGGGATAGGGAAGGAGGAGGGATGAGACCATCACCCCCTCCCAGAAGTAAATCTAGTATCTGAGTTTTCTTTATGCCCT TGAGTCAAACTAATAACTGTCTAGTACGGAGGTGTTTGCTGGTTTTCTTCGGTGTTTTTTCTAATGCAATAAACTCATTTCTGCCTGCTG CA >22402_22402_1_DGCR2-DESI1_DGCR2_chr22_19028571_ENST00000263196_DESI1_chr22_42003865_ENST00000263256_length(amino acids)=604AA_BP=465 MVPKADSGAFLLLFLLVLTVTEPLRPELRCNPGQFACRSGTIQCIPLPWQCDGWATCEDESDEANCPEVTGEVRPHHGKEAVDPRQGRAR GGDPSHFHAVNVAQPVRFSSFLGKCPTGWHHYEGTASCYRVYLSGENYWDAAQTCQRLNGSLATFSTDQELRFVLAQEWDQPERSFGWKD QRKLWVGYQYVITGRNRSLEGRWEVAFKGSSEVFLPPDPIFASAMSENDNVFCAQLQCFHFPTLRHHDLHSWHAESCYEKSSFLCKRSQT CVDIKDNVVDEGFYFTPKGDDPCLSCTCHGGEPEMCVAALCERPQGCQQYRKDPKECCKFMCLDPDGNSLFDSMASGMRLVVSCISSFLI LSLLLFMVHRLRQRRRERIESLIGANLHHFNLGRRIPGFDYGPDGFGTGLTPLHLSDDGEGGTFHFHDPPPPYTAYKYPDIGQPDDPPPP YEASIHPDSVFYDPAGKQLEGIWHTSIVVHKDEFFFGSGGISSCPPGGTLLGPPDSVVDVGSTEVTEEIFLEYLSSLGESLFRGEAYNLF EHNCNTFSNEVAQFLTGRKIPSYITDLPSEVLSTPFGQALRPLLDSIQIQPPGGSSVGRPNGQS -------------------------------------------------------------- >22402_22402_2_DGCR2-DESI1_DGCR2_chr22_19028571_ENST00000537045_DESI1_chr22_42003865_ENST00000263256_length(transcript)=5009nt_BP=1521nt GGGGCGGGGCGGCGCGGCGCGGAGCCGAGCAGGACGGCCGCCATCTTGCGCGCAGCTGGAGTCGGTGCCTGAGGTTGCAGCCGAGAGTGT GCGCCAGCCCGCGGCCCAGCCGAAGCTCTTTCCCGCCGCCTCTCCGCGCCTCGCCCAGGTTCAGCTCCGCCTGACCCTCCGCTTGGCACG GTCCCCTGACCCTCAGTCCGGCCTGGTCCGGCCTTCCAGCCGCCCCGGGGACGATGAACGGAGGATAAATGGTGCCCAAGGCAGACAGCG GCGCCTTCCTGCTGCTCTTCCTGCTCGTGCTCACTGTCACCGAGCCGCTGCGGCCAGAAGTGACCGGGGAGGTGCGTCCTCATCATGGGA AGGAGGCTGTGGATCCGCGGCAGGGGCGGGCCAGAGGAGGCGACCCTTCGCACTTCCACGCGGTGAACGTGGCGCAGCCCGTTCGCTTCA GCAGTTTCCTAGGGAAGTGCCCGACAGGGTGGCACCACTACGAAGGCACGGCCAGCTGCTACCGGGTCTACCTGAGCGGGGAGAACTACT GGGATGCCGCGCAGACCTGCCAGCGCCTGAATGGCTCTCTCGCCACCTTCTCCACTGACCAGGAGCTGCGCTTTGTCCTGGCCCAGGAAT GGGACCAGCCCGAGCGGAGCTTTGGTTGGAAGGACCAGCGCAAGTTGTGGGTTGGCTATCAGTATGTTATCACTGGCCGGAACCGCTCCT TGGAAGGTCGCTGGGAGGTGGCATTCAAAGGCTCTTCAGAGGTGTTCCTGCCCCCAGACCCCATCTTTGCCTCGGCCATGTCTGAGAACG ACAACGTGTTCTGTGCCCAGCTTCAGTGCTTCCATTTCCCCACCCTGCGGCACCACGACCTCCACAGCTGGCACGCCGAGAGCTGCTACG AGAAGTCTTCATTTCTGTGTAAAAGAAGTCAAACATGTGTTGACATCAAGGACAACGTGGTGGATGAAGGGTTCTACTTCACCCCTAAGG GGGACGACCCATGCCTGAGCTGCACCTGCCATGGAGGGGAGCCTGAGATGTGTGTGGCTGCTCTCTGTGAGAGGCCCCAGGGCTGCCAAC AGTACCGCAAGGACCCCAAAGAGTGCTGCAAGTTCATGTGTCTGGACCCAGATGGCAACAGTCTGTTTGACTCCATGGCCAGCGGGATGC GCCTGGTCGTCAGCTGCATCTCCTCCTTCCTCATCCTGTCACTGCTGCTCTTCATGGTCCACCGGCTGCGCCAGCGGCGCCGGGAGCGCA TCGAGTCCCTGATTGGAGCAAACTTGCACCACTTCAACCTCGGCCGCAGGATCCCTGGCTTTGATTACGGCCCAGACGGGTTTGGCACGG GCCTCACGCCGCTGCATCTTTCTGACGACGGAGAGGGTGGGACTTTCCATTTCCACGACCCTCCACCTCCCTACACGGCATACAAGTACC CGGACATCGGCCAGCCCGACGACCCTCCGCCGCCCTACGAGGCCTCCATCCACCCGGACAGTGTGTTCTATGACCCTGCAGGGAAACAAC TGGAAGGCATCTGGCACACATCCATAGTTGTGCACAAGGATGAGTTCTTCTTCGGCAGTGGTGGTATCTCCAGCTGCCCCCCGGGAGGGA CATTGCTTGGGCCTCCAGACTCTGTGGTTGATGTGGGGAGTACAGAAGTCACAGAAGAAATCTTTCTGGAGTACCTCTCCTCCCTGGGGG AGTCCCTGTTCCGAGGTGAGGCCTACAACCTCTTTGAACACAATTGTAACACCTTCAGCAACGAAGTGGCACAGTTCCTGACTGGGCGGA AGATTCCTTCTTACATCACAGACCTGCCCTCTGAAGTTCTCTCCACGCCCTTTGGACAGGCACTTCGGCCCCTCCTGGACTCCATTCAGA TCCAGCCTCCAGGAGGGAGCTCCGTGGGCAGACCCAACGGCCAGAGCTAACAGGACTGCCTGGGACCGCCCTGCCTCACCAGGGCTTTTC CTTTTTAAACAAAACAAACCCTACCAGATTTCTATTTTATAATTTTACATCAGAGCTAACAACCAGGGGACGGCTTTTTAAATTTCCCAG GGAAGGAGACCGTCAGGCCGCATGTAGACAATGCTGCTAAGAAACAGAACAAAATGCCACCCCTTCTAATAGTATTATACTAATTTATTA AGGCTGTCTTGTCTGTGCGTTCACTTCGGATGCTGTTTCCTAAGCGTCCTCCACACTGGAGAAAGGGAGGGGCTTTGTTTAAACAGAAAG CGAGTCACAGTTTGCGGGAGCCCCAACCTAGAACTCTTTCCAGAGAACACTCACGCTCTACCCAAGTTGCCAACACCTGTGGGACCCAGG TGAGTTTTAGAACATCCGTGACCCAGAAAGTTACTCTAGTGTTAAATGAACCAAAGGATTTGGTGTACATGGGACCGGTTTCAGGATGAC TAACCTAACCTAAGTGAACTCTTTAGCCACAACCCTCACCTTCCCTCCCTTACCCCAAGCAAGGCCAGTGCTGGAGCAGCCATTGCCTCC GGATCAAGGGAGTAACAGCAAGTATCAGGCCGGAGAAAACAGGATAAAGCCATTCCTCCTTCCACCTAGATGGATTGCCAATCTTCTGCC ATCAATTTTGGGAAACCTGCCTTTGTGCCCCCGAGGCTGCCTTTCCTCAGCATAGCTGACTTGTCATAGTGGATGAGGTCTGGGCTGGAG CAGTAGAAGCCAAGGCCTTTTTTCTGCAAGTAATGATGTAGGTTATTTGCAGTCTCTGTAACCACCATCCAGGCCAGTACGCAGTATTTA GCTGGGGACCAAGGGATGGGATTCCCTACTCTAAGAAAATACCTTTATTTTAATTATTATTATTTTTTGAGACGGAGTCTCGCTCTACCA CCCAGGCTGGTGTGCAGTGGCATGATCTCGGCTCACAGAAACCTCTGCCTCCCGGGTTCAAGTGGTTCTCCTGCCTCAGCCTCCTGAGTA GCTGGGATTACAGGTGCGTGCCACCACGCCAGGCTAATTTTTGTATTTTCAGTAGAGACAGGGTTTTGCCATGTTGGCCAGGCTGGTCTG GAACTCCTGACCTCGGGTGATCCACCTCCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCTGCCTGGCCAGAAAATAC CTTTGATATGGAAAGAATAATGATGTGAGGCCTGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCAGATC ACTTGAGGTCAGGACTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCGGGCATGGTGGCGC ATGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGATTGCGATGAGCCGAGATCGTACCA GTGCACTCCAGCCTGGGCGACAGAGTGAGACTCCATCTCAAAAAAATAAAATAATGAAGTGGAATCAAGGTGGCAAGAAAATTTAGAATC GTTTCTGATAGGGACTTTCCCTTATCCTAAATGTGTTTTGAAGGCACACGTTATTTCCATTGTCATTCTGACTTTAGAAAGGCAGGTTGG GGCATGAGTGGGCATTTTCCTAATGACTTGCTGCTAGGAGGTTATAGGCAGGGAACAGTCTGGGAGTCTCTAATCCAGAGAGACTTTCAG ATTCCCTCTCTTCACATGAACCTCCATTAGTTAGATTTTGGGAAAGTGAGCATGAAGAAGGGACTCAGAGCTGCCAGGTACCCGAGTCTC AGGTCTGACATCCTTGGGCCCCTTCTGCCACAACTTCTTGCCACTTCACGGACTTGAATTATGTTGCTTCTTCCTGGAAGTCTGGCCTGC AGCACAGGCCTTTCCTCTCCAAAAAGCTGCTGCTCATTTCTGGCCCCATCTGCTGCTATCTTTGCCATCAGCCATCACAGTTTGGCATCA TCAGAGTCTCAGCTAGAGGAGCTGTCATTCTGCCTTAGTGTTTGCCTGCGACCTGACCAGGGGCATGACCAGCTGGGATGTCAAGTGACA TTTGGGAACTTGTAGAGGCCAAATGATTGAAAGTTTAATTCTTCTCAAGACCCACTGATTTGCCAGTGTGCATGGAAATAATAGATTAGA GCAGAAACTAGCAGGGACTGTTGTATAATCGTGATCTACTAGCAGAATTGGGCCCAAAGAGAAAGAATTTCTGAGGCTGGGTTTCTTCTG GGAGGGTAGCAGGTTGGTCTTGGCCAGTGCTCTGTTTCCCACCAGTGTTGTTCCCTTTTCCAGCTTGCCTGGCCCGGCTCTGTCTTCCAG GGTCCTGCTCCAGACCCCTCTGCCTGGGGTCTCCCCTCCATCCAGGGGGTTCTGGGCATCACAGCTCCTTTTTTTCCTTTCTCCTCTTCC AGATCCAGTTTCAGCTGGTTTGCTTCTTCCAGCAGGCACCCTTAGGCCCAGGAGCAGCTCCCCTGAGAGAATTTGAGTCACTCATTTCCT TGAACAGCACCCCCCTTTATACTAGCAGCCATTTGTGCCATTGCCTGTGCCCTAGGGTTTGTGGGGAGAGAGCGAGGGATCACTGAGCAG TTTTCCCAGAGCTCCATGGGAAGGCAAGCTCTCCCTCCCAATGGGAGCCCCACTGTCACTAACTGTAAACTCAGGCTCAGGCTTCAACTG CCTACCCCCATCCTCATATTTCTGTCTGTCCCAGCACCTCAGGAGCATTCTCATTGTGGCCGGCTAACTCCGCCTGGATGTGAACAGGCA AGCACAGTGGGAAATGAGTCACGTACTTGTATTGCACAGTGGACACCTCTAGAGGTCCATTGGTTTAAAGGGATAGGGAAGGAGGAGGGA TGAGACCATCACCCCCTCCCAGAAGTAAATCTAGTATCTGAGTTTTCTTTATGCCCTTGAGTCAAACTAATAACTGTCTAGTACGGAGGT GTTTGCTGGTTTTCTTCGGTGTTTTTTCTAATGCAATAAACTCATTTCTGCCTGCTGCA >22402_22402_2_DGCR2-DESI1_DGCR2_chr22_19028571_ENST00000537045_DESI1_chr22_42003865_ENST00000263256_length(amino acids)=563AA_BP=424 MVPKADSGAFLLLFLLVLTVTEPLRPEVTGEVRPHHGKEAVDPRQGRARGGDPSHFHAVNVAQPVRFSSFLGKCPTGWHHYEGTASCYRV YLSGENYWDAAQTCQRLNGSLATFSTDQELRFVLAQEWDQPERSFGWKDQRKLWVGYQYVITGRNRSLEGRWEVAFKGSSEVFLPPDPIF ASAMSENDNVFCAQLQCFHFPTLRHHDLHSWHAESCYEKSSFLCKRSQTCVDIKDNVVDEGFYFTPKGDDPCLSCTCHGGEPEMCVAALC ERPQGCQQYRKDPKECCKFMCLDPDGNSLFDSMASGMRLVVSCISSFLILSLLLFMVHRLRQRRRERIESLIGANLHHFNLGRRIPGFDY GPDGFGTGLTPLHLSDDGEGGTFHFHDPPPPYTAYKYPDIGQPDDPPPPYEASIHPDSVFYDPAGKQLEGIWHTSIVVHKDEFFFGSGGI SSCPPGGTLLGPPDSVVDVGSTEVTEEIFLEYLSSLGESLFRGEAYNLFEHNCNTFSNEVAQFLTGRKIPSYITDLPSEVLSTPFGQALR PLLDSIQIQPPGGSSVGRPNGQS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for DGCR2-PPPDE2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DGCR2-PPPDE2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DGCR2-PPPDE2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DGCR2 | C0036341 | Schizophrenia | 1 | CTD_human |
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