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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:DGCR2-GNB1L (FusionGDB2 ID:HG9993TG54584)

Fusion Gene Summary for DGCR2-GNB1L

check button Fusion gene summary
Fusion gene informationFusion gene name: DGCR2-GNB1L
Fusion gene ID: hg9993tg54584
HgeneTgene
Gene symbol

DGCR2

GNB1L

Gene ID

9993

54584

Gene nameDiGeorge syndrome critical region gene 2G protein subunit beta 1 like
SynonymsDGS-C|IDD|LAN|SEZ-12DGCRK3|FKSG1|GY2|WDR14|WDVCF
Cytomap('DGCR2')('GNB1L')

22q11.21

22q11.21

Type of geneprotein-codingprotein-coding
Descriptionintegral membrane protein DGCR2/IDDDiGeorge syndrome critical region protein 2integral membrane protein deleted in DiGeorge syndromeguanine nucleotide-binding protein subunit beta-like protein 1G-protein beta subunit-like proteinWD repeat-containing protein 14WD40 repeat-containing protein deleted in VCFSg protein subunit beta-like protein 1guanine nucleotide binding protein (G p
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000263196, ENST00000537045, 
ENST00000545799, ENST00000473832, 
Fusion gene scores* DoF score16 X 15 X 8=19208 X 8 X 6=384
# samples 219
** MAII scorelog2(21/1920*10)=-3.1926450779424
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/384*10)=-2.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DGCR2 [Title/Abstract] AND GNB1L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDGCR2(19052361)-GNB1L(19776483), # samples:3
Anticipated loss of major functional domain due to fusion event.DGCR2-GNB1L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DGCR2-GNB1L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DGCR2-GNB1L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DGCR2-GNB1L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DGCR2-GNB1L seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DGCR2-GNB1L seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DGCR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across GNB1L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-FS-A1ZK-06ADGCR2chr22

19052361

-GNB1Lchr22

19776483

-
ChimerDB4SKCMTCGA-FS-A1ZKDGCR2chr22

19052360

-GNB1Lchr22

19776483

-


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Fusion Gene ORF analysis for DGCR2-GNB1L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000263196ENST00000460402DGCR2chr22

19052361

-GNB1Lchr22

19776483

-
5CDS-5UTRENST00000263196ENST00000460402DGCR2chr22

19052360

-GNB1Lchr22

19776483

-
5CDS-5UTRENST00000537045ENST00000460402DGCR2chr22

19052361

-GNB1Lchr22

19776483

-
5CDS-5UTRENST00000537045ENST00000460402DGCR2chr22

19052360

-GNB1Lchr22

19776483

-
5CDS-5UTRENST00000545799ENST00000460402DGCR2chr22

19052361

-GNB1Lchr22

19776483

-
5CDS-5UTRENST00000545799ENST00000460402DGCR2chr22

19052360

-GNB1Lchr22

19776483

-
5CDS-intronENST00000263196ENST00000405009DGCR2chr22

19052361

-GNB1Lchr22

19776483

-
5CDS-intronENST00000263196ENST00000405009DGCR2chr22

19052360

-GNB1Lchr22

19776483

-
5CDS-intronENST00000537045ENST00000405009DGCR2chr22

19052361

-GNB1Lchr22

19776483

-
5CDS-intronENST00000537045ENST00000405009DGCR2chr22

19052360

-GNB1Lchr22

19776483

-
5CDS-intronENST00000545799ENST00000405009DGCR2chr22

19052361

-GNB1Lchr22

19776483

-
5CDS-intronENST00000545799ENST00000405009DGCR2chr22

19052360

-GNB1Lchr22

19776483

-
5UTR-3CDSENST00000473832ENST00000329517DGCR2chr22

19052361

-GNB1Lchr22

19776483

-
5UTR-3CDSENST00000473832ENST00000329517DGCR2chr22

19052360

-GNB1Lchr22

19776483

-
5UTR-3CDSENST00000473832ENST00000403325DGCR2chr22

19052361

-GNB1Lchr22

19776483

-
5UTR-3CDSENST00000473832ENST00000403325DGCR2chr22

19052360

-GNB1Lchr22

19776483

-
5UTR-5UTRENST00000473832ENST00000460402DGCR2chr22

19052361

-GNB1Lchr22

19776483

-
5UTR-5UTRENST00000473832ENST00000460402DGCR2chr22

19052360

-GNB1Lchr22

19776483

-
5UTR-intronENST00000473832ENST00000405009DGCR2chr22

19052361

-GNB1Lchr22

19776483

-
5UTR-intronENST00000473832ENST00000405009DGCR2chr22

19052360

-GNB1Lchr22

19776483

-
Frame-shiftENST00000263196ENST00000329517DGCR2chr22

19052361

-GNB1Lchr22

19776483

-
Frame-shiftENST00000263196ENST00000329517DGCR2chr22

19052360

-GNB1Lchr22

19776483

-
Frame-shiftENST00000263196ENST00000403325DGCR2chr22

19052361

-GNB1Lchr22

19776483

-
Frame-shiftENST00000263196ENST00000403325DGCR2chr22

19052360

-GNB1Lchr22

19776483

-
Frame-shiftENST00000537045ENST00000329517DGCR2chr22

19052361

-GNB1Lchr22

19776483

-
Frame-shiftENST00000537045ENST00000329517DGCR2chr22

19052360

-GNB1Lchr22

19776483

-
Frame-shiftENST00000537045ENST00000403325DGCR2chr22

19052361

-GNB1Lchr22

19776483

-
Frame-shiftENST00000537045ENST00000403325DGCR2chr22

19052360

-GNB1Lchr22

19776483

-
In-frameENST00000545799ENST00000329517DGCR2chr22

19052361

-GNB1Lchr22

19776483

-
In-frameENST00000545799ENST00000329517DGCR2chr22

19052360

-GNB1Lchr22

19776483

-
In-frameENST00000545799ENST00000403325DGCR2chr22

19052361

-GNB1Lchr22

19776483

-
In-frameENST00000545799ENST00000403325DGCR2chr22

19052360

-GNB1Lchr22

19776483

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000545799DGCR2chr2219052361-ENST00000329517GNB1Lchr2219776483-64777402011064287
ENST00000545799DGCR2chr2219052361-ENST00000403325GNB1Lchr2219776483-12867402011064287
ENST00000545799DGCR2chr2219052360-ENST00000329517GNB1Lchr2219776483-64777402011064287
ENST00000545799DGCR2chr2219052360-ENST00000403325GNB1Lchr2219776483-12867402011064287

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000545799ENST00000329517DGCR2chr2219052361-GNB1Lchr2219776483-0.200925190.79907477
ENST00000545799ENST00000403325DGCR2chr2219052361-GNB1Lchr2219776483-0.395583750.60441625
ENST00000545799ENST00000329517DGCR2chr2219052360-GNB1Lchr2219776483-0.200925190.79907477
ENST00000545799ENST00000403325DGCR2chr2219052360-GNB1Lchr2219776483-0.395583750.60441625

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Fusion Genomic Features for DGCR2-GNB1L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for DGCR2-GNB1L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:19052361/chr22:19776483)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDGCR2chr22:19052360chr22:19776483ENST00000263196-41028_68182551.0DomainLDL-receptor class A
HgeneDGCR2chr22:19052360chr22:19776483ENST00000537045-3928_68141510.0DomainLDL-receptor class A
HgeneDGCR2chr22:19052361chr22:19776483ENST00000263196-41028_68182551.0DomainLDL-receptor class A
HgeneDGCR2chr22:19052361chr22:19776483ENST00000537045-3928_68141510.0DomainLDL-receptor class A
TgeneGNB1Lchr22:19052360chr22:19776483ENST00000405009084_120213.0Compositional biasNote=Poly-Pro
TgeneGNB1Lchr22:19052361chr22:19776483ENST00000405009084_120213.0Compositional biasNote=Poly-Pro
TgeneGNB1Lchr22:19052360chr22:19776483ENST0000032951768242_282244328.0RepeatNote=WD 6
TgeneGNB1Lchr22:19052360chr22:19776483ENST0000032951768286_323244328.0RepeatNote=WD 7
TgeneGNB1Lchr22:19052360chr22:19776483ENST0000040332557242_282244328.0RepeatNote=WD 6
TgeneGNB1Lchr22:19052360chr22:19776483ENST0000040332557286_323244328.0RepeatNote=WD 7
TgeneGNB1Lchr22:19052360chr22:19776483ENST0000040500908103_1450213.0RepeatNote=WD 3
TgeneGNB1Lchr22:19052360chr22:19776483ENST0000040500908153_1950213.0RepeatNote=WD 4
TgeneGNB1Lchr22:19052360chr22:19776483ENST000004050090816_540213.0RepeatNote=WD 1
TgeneGNB1Lchr22:19052360chr22:19776483ENST0000040500908200_2370213.0RepeatNote=WD 5
TgeneGNB1Lchr22:19052360chr22:19776483ENST0000040500908242_2820213.0RepeatNote=WD 6
TgeneGNB1Lchr22:19052360chr22:19776483ENST0000040500908286_3230213.0RepeatNote=WD 7
TgeneGNB1Lchr22:19052360chr22:19776483ENST000004050090858_970213.0RepeatNote=WD 2
TgeneGNB1Lchr22:19052361chr22:19776483ENST0000032951768242_282244328.0RepeatNote=WD 6
TgeneGNB1Lchr22:19052361chr22:19776483ENST0000032951768286_323244328.0RepeatNote=WD 7
TgeneGNB1Lchr22:19052361chr22:19776483ENST0000040332557242_282244328.0RepeatNote=WD 6
TgeneGNB1Lchr22:19052361chr22:19776483ENST0000040332557286_323244328.0RepeatNote=WD 7
TgeneGNB1Lchr22:19052361chr22:19776483ENST0000040500908103_1450213.0RepeatNote=WD 3
TgeneGNB1Lchr22:19052361chr22:19776483ENST0000040500908153_1950213.0RepeatNote=WD 4
TgeneGNB1Lchr22:19052361chr22:19776483ENST000004050090816_540213.0RepeatNote=WD 1
TgeneGNB1Lchr22:19052361chr22:19776483ENST0000040500908200_2370213.0RepeatNote=WD 5
TgeneGNB1Lchr22:19052361chr22:19776483ENST0000040500908242_2820213.0RepeatNote=WD 6
TgeneGNB1Lchr22:19052361chr22:19776483ENST0000040500908286_3230213.0RepeatNote=WD 7
TgeneGNB1Lchr22:19052361chr22:19776483ENST000004050090858_970213.0RepeatNote=WD 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDGCR2chr22:19052360chr22:19776483ENST00000263196-410115_241182551.0DomainC-type lectin
HgeneDGCR2chr22:19052360chr22:19776483ENST00000263196-410270_333182551.0DomainNote=VWFC
HgeneDGCR2chr22:19052360chr22:19776483ENST00000537045-39115_241141510.0DomainC-type lectin
HgeneDGCR2chr22:19052360chr22:19776483ENST00000537045-39270_333141510.0DomainNote=VWFC
HgeneDGCR2chr22:19052361chr22:19776483ENST00000263196-410115_241182551.0DomainC-type lectin
HgeneDGCR2chr22:19052361chr22:19776483ENST00000263196-410270_333182551.0DomainNote=VWFC
HgeneDGCR2chr22:19052361chr22:19776483ENST00000537045-39115_241141510.0DomainC-type lectin
HgeneDGCR2chr22:19052361chr22:19776483ENST00000537045-39270_333141510.0DomainNote=VWFC
HgeneDGCR2chr22:19052360chr22:19776483ENST00000263196-41021_349182551.0Topological domainExtracellular
HgeneDGCR2chr22:19052360chr22:19776483ENST00000263196-410369_550182551.0Topological domainCytoplasmic
HgeneDGCR2chr22:19052360chr22:19776483ENST00000537045-3921_349141510.0Topological domainExtracellular
HgeneDGCR2chr22:19052360chr22:19776483ENST00000537045-39369_550141510.0Topological domainCytoplasmic
HgeneDGCR2chr22:19052361chr22:19776483ENST00000263196-41021_349182551.0Topological domainExtracellular
HgeneDGCR2chr22:19052361chr22:19776483ENST00000263196-410369_550182551.0Topological domainCytoplasmic
HgeneDGCR2chr22:19052361chr22:19776483ENST00000537045-3921_349141510.0Topological domainExtracellular
HgeneDGCR2chr22:19052361chr22:19776483ENST00000537045-39369_550141510.0Topological domainCytoplasmic
HgeneDGCR2chr22:19052360chr22:19776483ENST00000263196-410350_368182551.0TransmembraneHelical
HgeneDGCR2chr22:19052360chr22:19776483ENST00000537045-39350_368141510.0TransmembraneHelical
HgeneDGCR2chr22:19052361chr22:19776483ENST00000263196-410350_368182551.0TransmembraneHelical
HgeneDGCR2chr22:19052361chr22:19776483ENST00000537045-39350_368141510.0TransmembraneHelical
TgeneGNB1Lchr22:19052360chr22:19776483ENST00000329517684_12244328.0Compositional biasNote=Poly-Pro
TgeneGNB1Lchr22:19052360chr22:19776483ENST00000403325574_12244328.0Compositional biasNote=Poly-Pro
TgeneGNB1Lchr22:19052361chr22:19776483ENST00000329517684_12244328.0Compositional biasNote=Poly-Pro
TgeneGNB1Lchr22:19052361chr22:19776483ENST00000403325574_12244328.0Compositional biasNote=Poly-Pro
TgeneGNB1Lchr22:19052360chr22:19776483ENST0000032951768103_145244328.0RepeatNote=WD 3
TgeneGNB1Lchr22:19052360chr22:19776483ENST0000032951768153_195244328.0RepeatNote=WD 4
TgeneGNB1Lchr22:19052360chr22:19776483ENST000003295176816_54244328.0RepeatNote=WD 1
TgeneGNB1Lchr22:19052360chr22:19776483ENST0000032951768200_237244328.0RepeatNote=WD 5
TgeneGNB1Lchr22:19052360chr22:19776483ENST000003295176858_97244328.0RepeatNote=WD 2
TgeneGNB1Lchr22:19052360chr22:19776483ENST0000040332557103_145244328.0RepeatNote=WD 3
TgeneGNB1Lchr22:19052360chr22:19776483ENST0000040332557153_195244328.0RepeatNote=WD 4
TgeneGNB1Lchr22:19052360chr22:19776483ENST000004033255716_54244328.0RepeatNote=WD 1
TgeneGNB1Lchr22:19052360chr22:19776483ENST0000040332557200_237244328.0RepeatNote=WD 5
TgeneGNB1Lchr22:19052360chr22:19776483ENST000004033255758_97244328.0RepeatNote=WD 2
TgeneGNB1Lchr22:19052361chr22:19776483ENST0000032951768103_145244328.0RepeatNote=WD 3
TgeneGNB1Lchr22:19052361chr22:19776483ENST0000032951768153_195244328.0RepeatNote=WD 4
TgeneGNB1Lchr22:19052361chr22:19776483ENST000003295176816_54244328.0RepeatNote=WD 1
TgeneGNB1Lchr22:19052361chr22:19776483ENST0000032951768200_237244328.0RepeatNote=WD 5
TgeneGNB1Lchr22:19052361chr22:19776483ENST000003295176858_97244328.0RepeatNote=WD 2
TgeneGNB1Lchr22:19052361chr22:19776483ENST0000040332557103_145244328.0RepeatNote=WD 3
TgeneGNB1Lchr22:19052361chr22:19776483ENST0000040332557153_195244328.0RepeatNote=WD 4
TgeneGNB1Lchr22:19052361chr22:19776483ENST000004033255716_54244328.0RepeatNote=WD 1
TgeneGNB1Lchr22:19052361chr22:19776483ENST0000040332557200_237244328.0RepeatNote=WD 5
TgeneGNB1Lchr22:19052361chr22:19776483ENST000004033255758_97244328.0RepeatNote=WD 2


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Fusion Gene Sequence for DGCR2-GNB1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22405_22405_1_DGCR2-GNB1L_DGCR2_chr22_19052360_ENST00000545799_GNB1L_chr22_19776483_ENST00000329517_length(transcript)=6477nt_BP=740nt
GCGCGCAGCTGGAGTCGGTGCCTGAGGTTGCAGCCGAGAGTGTGCGCCAGCCCGCGGCCCAGCCGAAGCTCTTTCCCGCCGCCTCTCCGC
GCCTCGCCCAGGTTCAGCTCCGCCTGACCCTCCGCTTGGCACGGTCCCCTGACCCTCAGTCCGGCCTGGTCCGGCCTTCCAGCCGCCCCG
GGGACGATGAACGGAGGATAAATGGTGCCCAAGGCAGACAGCGGCGCCTTCCTGCTGCTCTTCCTGCTCGTGCTCACTGTCACCGAGCCG
CTGCGGCCAGAGCTGCGGTGCAACCCTGGGCAGTTTGCGTGTCGCAGCGGCACCATCCAGTGCATCCCCCTCCCCTGGCAGTGTGACGGC
TGGGCGACTTGCGAGGATGAGAGCGACGAAGCCAACTGTCCAGAAGTGACCGGGGAGGTGCGTCCTCATCATGGGAAGGAGGCTGTGGAT
CCGCGGCAGGGGCGGGCCAGAGGAGGCGACCCTTCGCACTTCCACGCGGTGAACGTGGCGCAGCCCGTTCGCTTCAGCAGGAAGTGCCCG
ACAGGGTGGCACCACTACGAAGGCACGGCCAGCTGCTACCGGGTCTACCTGAGCGGGGAGAACTACTGGGATGCCGCGCAGACCTGCCAG
CGCCTGAATGGCTCTCTCGCCACCTTCTCCACTGACCAGGAGCTGCGCTTTGTCCTGGCCCAGGAATGGGACCAGCCCGAGCGGAGCTTT
GGTTGGAAGGACCAGCGCAAGTGCGTGGGACTCATGAACTCACCAATCCCGGGATCGCCGAGGTCACGATCCGGCCAGATCGCAAGATCC
TGGCCACCGCAGGCTGGGACCACCGCATCCGCGTGTTCCACTGGCGGACGATGCAGCCACTGGCCGTGCTGGCCTTCCACAGCGCCGCTG
TCCAGTGCGTGGCCTTCACCGCCGATGGCTTGCTGGCCGCGGGCTCCAAGGATCAGCGGATCAGCCTCTGGTCACTCTACCCACGCGCAT
GACTCACCCACTCCCTTCCCGGGAGACGAGGAGGGCGGGCAGGGAGGTGGGCATCAGGCCCCAGCCTTGGCCTGAAACCTCAAGGGCCTC
TGAGGACCAGCAAGTCATGGCCCAAGGACCATGGAGTCCCCGCTGTCTTCATGAGGTTGGTATTTCCTTTTGTGGAGTGCCTCATCACAG
GACGGTGACTCTGGGGGCCAGCCAGAGCCCTGGCCGTCCGAGGCCTGCAGGAGACGTTGGCTTGGGCCTGCTGTGTTGCCAGCTGAGGGT
ATTTTATAATAAATTTCCATTGCCAAGTTGCAGGCTTGAGGTGGGAGCTCCCTGAGGAGGCCCTGGTCCCCCACTTAGCATCAGTGCCCT
CAGACCCCCACCAGGCAGGATGCTCAGCCCCACCCTCACACCTGCTGTTGAATGGGCCACCCCGAGTGTGGGTTTCCTGGGCCAGGCCTC
AGGAGATGATAGGCCCCAACCATAGCTGCGTCGATGTCCACATGACCCCTCACCCCGAGGAGGCCAGGAGCTCCCAACACACAGGTTGAG
GCCAGGATCAGGATCAGGAAGTAACTGAACTCCCTAAAGAGTGAAGCAGAGAAAGGTGCCTGTGAGGGACGGCAAGGGGGGCTTGCAGCG
CACAGGGCCAGGCCAGATGTGGGATCCGGGAGGGCACGCCTGCCCGCAGAGGGTGCAGTGGGGAAGGCGCACAGGGTGCACCTCCAGGTG
AGTGCTGGGCAGAAGGCACGAGAGCAGCAAGGGAGTGTGACAAGCACCGCCTCACAGTGGCCAAGGCCACAGTCACAGCTGCGGCTGCAC
ACAGGGTGGCCCCCAGGGCACAACACAGCAAGAGCAGGACTTAGCAGCCAGAGCCTCACACTGCATGCAGCCGGGCCCAGCCTGGCCGGT
CGTCTCCTCCTAAAAGCGGGTGTTGATTGGGAAAGAACCATGACCCTGAATATTGGAGTGGGGCCCATGGGCAGATCCAGAGAAGCTGGG
ACCACACACGCCTGTGTCTGCCCGGATTGCCGGAAGAGCCCCTCTAGCTGAAGGCCCGGGGTGGCCTCCCTTGAGGCAGTTGCCCTGCAA
GGCCCTGCCGATGCTCCTTGGGACCCCCACCTGGGCTTCTAGTCCTAGAACTAGACTCGAGTCCAGCAGACCCCCAGGATGAGATACAGA
GGGTGACCCTGAGAGTGGCACCAGCCTCCTGCAGGACCACATGGCATTTCCAGGTTTCCAGGCAGAAATCTGAACATGTGTGGGACGGAT
CGGAAGGGTGTGGGATCCAGGTGGCCGGAGCAGGGGTGGATCAGGGGAGTTCCCGGAACAGACCTGCCAAACGGAGGGCTGGACTGGGCG
CTGCAGCTTGGGGCCAGGAAGGCTCCAGTGCCGGGCTGGGGGTGGGGGCTGGATTACAGCCTGAGGGTGGCTGCACTGAGTGAAGTGGAC
ATGGCCAGCCGCCGTGGGGTACAGCCGAGGAGGGCTTCCAAGGCCTGGGGATGGGGGTGTTGGATTTGTCAGTGAGACCTGTGCACCCAC
TGCAGGGGGTCCCAAGGCCGTGCCTCCCCAACCCCACTGTGAGGAACATGGTTGCTGGGGGGCCCGGAGTCCTTGAGGAGTCCTGTGACC
ACACTTCTCTGTTGGTCAGAGGTACCATGGGGACCGTTCCATCAAACGGGAATGTCAGTGCTGGCCGGGAAAGCGGCCCCTGGCCCAAGC
TTGGAGACCACCTGGCTCGGGTACTGGCCTGGCTCCGTTGGACAAGGGTGGCCACCAGGTGCCCAGGACCTTTGGAGAGGGGGGCCCTGC
TGCTTTTCCTCGAGTGTCCTATAGCCGCCAGGATGCGTAGGGCACTCCGGGAGGTATTTTCATATCACTGAGGTGTCAGGGAGGGGAAGG
GTCCTGGGTTTAGGCTGCAGTGACTGCAGGTGCTGAGGGAGCTGTGCCCTGGGTGCTCATCACAGGCTGTCACAGTGAGGGAAGGTGTCA
GGTTCTGACATCCCCATGACAGCGGCAGGGTAGGTGGAGTGGGAATTGGCTTTGCAGTTTCCCTGCATGCCCTTGACAGCCTTGCCAAAG
GCACATCTGCCCCGCCTCAGCTCCCACCCTGAGGGTTCTGGGCCTCTACCCCTTCCCCTGTTTATGTCCCTGTCATCTTTGGCATCATCA
CTGTAGTTACAAAACTCCCTACGTCCCACAGCCACGAGGTGGGTATCCCACATGAGGGCCCAGGTGTGCATGCCAGCATGAGGTTGGCGA
GTGGCACTGCCTGCTGATGTCTTACATAGAGGCCATGAAGAGCTGTGGGCAGGGTGTACAGACCCTGAGTTGGCCCCTGGCCCTCGTGCT
TTCAGTCAAAGGCACAAGCAGGGTGGATGGCAGGCGGCTGCCCCCTAGCCTGGCCTTGAGCTCCCTGCCCCAGGCCATGTGGCGTTGAGC
AGTGTCCAGGCACATCTTGTTCTGAATCTCAGTGTGCAGGGATGGAGTCGGGACAGCGTGAGTCCTGCATGCCTAACACAGCCCTCACCC
CTCCAGTGCACAACGGGGCCACGTGCCCGCATCTGGGTGGCTAGGCAGATAGGGCCCCCCTTGCCAGGCAGATCCAGCTTCTGAGGCCTT
ATAGACGTCCTGTGGAGGGCAGGCCCAGGACTTTCATTCACCTGGCTGAGCTGCCTGGGAGAGCAGCAGAACCGGTGCTGGGGTCCAAGC
CGGCCAAGAGCAGTGCAGCCCTCCTGGTCCTGTTCCTCTCTTGAGCTGCTCCGTGGTGTCCACAGCAGAGCCATGTGGCTCTGGACAGGT
CGGCCTTTGTGTCAACAGAACCTGGGTCGTGATGAATCACCATGCGTCTGACCAGCCTTGAAACCCCCACAACAGAAGAAGAAACGGTCT
CAGCTCCAGACATCCAGCTTGGAAAAGATGCACCTGAACATTGGCATTCTCTTCCTAGCAAACAGCCACTTCCTGTAGGCTGGCAGGAAC
GCCAACAGAGCCAGCAGTGAAGGCATTAAGTGGGGAGGAGGGGTGGCCCGGAGGCAGCACGCGAAGGTCAGCATGCAGCTCCTGGGATGA
ACCTGAGAGGCGACTCCTGGCAGCATGGCTGGTCGCTGCCATCACGCCCCTGGCCAACCCACCAACTGGGAGAGGCAGCCCTTCCACATC
TTCCTCCATAATGCTCTTGGGTAGCAGTGAGGCCTCTCAAGCCAGAGAGAACTTGGTGTTTGGAAACAACGGCGGACATTTCTTGCCATT
TTCAGTGCCAACTCAGGTAGGTGTGTTCTACCATCCTGTGTTTTTGGGGTGTTTTTTTTTTTGAGTCAGAGTCTCACTCTGTCCCCCAGG
CTGGAGTGCAATGGAGCAGTCTCGGCTCACTGCAACCTCTGATTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGAAGCTCAG
GACCACCCACATAGGTGCAGGCCATCATGCCCAGCTAATTTTTTATTTTTTTTTATAGAGAAGGAGTCTCGCTATGTTGCCCAGGCTGGT
TTCGAACTCCTGGGCTCAAGCGATCGATCCTCCCGCCTCTAGCCTCCCAAAGCACTAGAATTATAGGCCTGAGCCACTGCGCCCGGCCCA
CCATCCTGTTCTTATTGGAAGAATTTCCATGTGTCGAGGCACGGGCACAACGTAGCTGGTCCTCTGCTCAGGGCCCCACAAGGCTGCGTC
AGGGTGGCAGCGCGGCTGGGGGCTTTTTCTGTTCAAATCCAGATTCTCGTGGCTGTGAGCCCCAGCCCTGGGCACTGTCCGCCTGGTGGT
GTCTTCACAGCCAGCAGGGGTGGCCTTGGGGTGTTCTGTGGAGTAACTTTCACGGCCCAGAGTGGGATCCTGAGTGGCTGGAGCCGTATG
CTCCAGCATCCCCAGCCGCTGCCTCCGGTGCAGGTGGAGTGGGCCCCTCTGATTACCAGGAGCTGTCAGAGGGGCAGCAGGTCCCACTCC
ACTGGCCGGTGGGCAGCTGTGTGCAGGGACGCGGGTCCTGGCACGTCTGCCTGGTGAGGCCCTGCCTCCAGTGCCAAGGGGCCTCCCCTC
TCGACGGTGGGCGCCACCATGTGCTGACCTCTGTGCAGCCCCACTTTACAAGGTAGGTTCGGCCAGCACCCCATCCGCGGGCGGGCAGCA
CTCACCCAGCGTTGCGCCGCCAACAGGGTCCCTCTTAGACAAGCAGCTGTGCCTAGAGCCTTTTCCTTCCTCCCTGCGTGTTACCTGCAG
GCCAACAGACGGCCCTGGGTCTGGGACCAGGAGAACCTGCCTCCGCCTCTGGCAGTGGGTGTCCCTGCAGGCAGATTGGGCTTGGCACGT
AGACACCGAGGGGTCAGCCGATGCCGGGAGATGATCCCGGGAAGGGCTCCGGAGCACAGCCCAGGACCCGCCGCCGCTGCTGGGCGCTCC
ATGTTGACGTGCTGTGCGTGTCTCCACTCCCCAGGCAATGATGTTCAATCAGGTGTTTCCCACCTGTGTCTCTGCCAAGAAGCCACAGAA
CACCCTCTGCACAAAAGGAGTGTTTGCACAAAGAAAAACAACCCTCCGGGGGTTCTTTAGAAATGCTTATACTCAATTAGCTAGAACTTC
ATGTGAAATCCCAGCGTGGAAGACAACAAGCCGGCACCGGTGAAAACTTTGCTGTGCACCTGCCCTCTACCAAGCTGCCAGCCCCACCAG
CCCTGTGGTCCTAGGTGGGCACAGCTGCTGCACGGTCCCCCAGGCCTGCCTCTCCTCGGGGTCTCAACCTTCATACCAGATTTGCCAGCA
TCCCCATTCCCGCCTTGTGGGTGGAGAGTCCTTGAGACCCTCTGTCACTCTGTCAGCTTCCCCAGGTCAGCGAGCTGTGGCTTGGCTCCC
ACGCATCAGCTTTTATGGGAGGCCCATTAGGAGCTGGGCAGGAGGGACAGAGGGGAGGCCAGGCAGCCACTGCTGAGTGGGACGGGTAGC
CCAGCCCATGAGGCTGGCCAGCCCTACAGGGGAGGTCCCACAGCACTGGCCGGGAAGTCCACATAGGAAAGCATCAGTTGAGGGATGAAG
CCACGGACGATGGGGACAACGGCCACAGGGTGTGCTAAGCTGAGGAAATTAGTAGGAGGTGCTCATAAGCTGTTTTGTTTTTTGGTTTGT
TTGTTTGTTTTTTCTTTTAAGAGACCAGGGACAGTGGGGGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCATGATCATAGCTTACT
GCAGCCTCCAACTAATAGGCTCAAGTGATCCTCCTGCCTCAGCCTCCCGAGTAACTCATGGCCTTTAAGTGAACTGCTTCCACCATCCAG
CTGTGCAGGTGGCCTGGGAACAGCAGCACATCTGTCCCCTGCCACCTCTTGCATGCACACTTGACCTCCTGACTTGGGCTCTGAAACCTG
TAAAATGTGGGGTGTAGAGAAATCGAGTCATTTGGCCTCATCCTGGTGCCATTATCTCTTGCTACATTAATAAACCACCTCAAACAG

>22405_22405_1_DGCR2-GNB1L_DGCR2_chr22_19052360_ENST00000545799_GNB1L_chr22_19776483_ENST00000329517_length(amino acids)=287AA_BP=180
MVPKADSGAFLLLFLLVLTVTEPLRPELRCNPGQFACRSGTIQCIPLPWQCDGWATCEDESDEANCPEVTGEVRPHHGKEAVDPRQGRAR
GGDPSHFHAVNVAQPVRFSRKCPTGWHHYEGTASCYRVYLSGENYWDAAQTCQRLNGSLATFSTDQELRFVLAQEWDQPERSFGWKDQRK
CVGLMNSPIPGSPRSRSGQIARSWPPQAGTTASACSTGGRCSHWPCWPSTAPLSSAWPSPPMACWPRAPRISGSASGHSTHAHDSPTPFP
GDEEGGQGGGHQAPALA

--------------------------------------------------------------
>22405_22405_2_DGCR2-GNB1L_DGCR2_chr22_19052360_ENST00000545799_GNB1L_chr22_19776483_ENST00000403325_length(transcript)=1286nt_BP=740nt
GCGCGCAGCTGGAGTCGGTGCCTGAGGTTGCAGCCGAGAGTGTGCGCCAGCCCGCGGCCCAGCCGAAGCTCTTTCCCGCCGCCTCTCCGC
GCCTCGCCCAGGTTCAGCTCCGCCTGACCCTCCGCTTGGCACGGTCCCCTGACCCTCAGTCCGGCCTGGTCCGGCCTTCCAGCCGCCCCG
GGGACGATGAACGGAGGATAAATGGTGCCCAAGGCAGACAGCGGCGCCTTCCTGCTGCTCTTCCTGCTCGTGCTCACTGTCACCGAGCCG
CTGCGGCCAGAGCTGCGGTGCAACCCTGGGCAGTTTGCGTGTCGCAGCGGCACCATCCAGTGCATCCCCCTCCCCTGGCAGTGTGACGGC
TGGGCGACTTGCGAGGATGAGAGCGACGAAGCCAACTGTCCAGAAGTGACCGGGGAGGTGCGTCCTCATCATGGGAAGGAGGCTGTGGAT
CCGCGGCAGGGGCGGGCCAGAGGAGGCGACCCTTCGCACTTCCACGCGGTGAACGTGGCGCAGCCCGTTCGCTTCAGCAGGAAGTGCCCG
ACAGGGTGGCACCACTACGAAGGCACGGCCAGCTGCTACCGGGTCTACCTGAGCGGGGAGAACTACTGGGATGCCGCGCAGACCTGCCAG
CGCCTGAATGGCTCTCTCGCCACCTTCTCCACTGACCAGGAGCTGCGCTTTGTCCTGGCCCAGGAATGGGACCAGCCCGAGCGGAGCTTT
GGTTGGAAGGACCAGCGCAAGTGCGTGGGACTCATGAACTCACCAATCCCGGGATCGCCGAGGTCACGATCCGGCCAGATCGCAAGATCC
TGGCCACCGCAGGCTGGGACCACCGCATCCGCGTGTTCCACTGGCGGACGATGCAGCCACTGGCCGTGCTGGCCTTCCACAGCGCCGCTG
TCCAGTGCGTGGCCTTCACCGCCGATGGCTTGCTGGCCGCGGGCTCCAAGGATCAGCGGATCAGCCTCTGGTCACTCTACCCACGCGCAT
GACTCACCCACTCCCTTCCCGGGAGACGAGGAGGGCGGGCAGGGAGGTGGGCATCAGGCCCCAGCCTTGGCCTGAAACCTCAAGGGCCTC
TGAGGACCAGCAAGTCATGGCCCAAGGACCATGGAGTCCCCGCTGTCTTCATGAGGTTGGTATTTCCTTTTGTGGAGTGCCTCATCACAG
GACGGTGACTCTGGGGGCCAGCCAGAGCCCTGGCCGTCCGAGGCCTGCAGGAGACGTTGGCTTGGGCCTGCTGTGTTGCCAGCTGAGGGT
ATTTTATAATAAATTTCCATTGCCAA

>22405_22405_2_DGCR2-GNB1L_DGCR2_chr22_19052360_ENST00000545799_GNB1L_chr22_19776483_ENST00000403325_length(amino acids)=287AA_BP=180
MVPKADSGAFLLLFLLVLTVTEPLRPELRCNPGQFACRSGTIQCIPLPWQCDGWATCEDESDEANCPEVTGEVRPHHGKEAVDPRQGRAR
GGDPSHFHAVNVAQPVRFSRKCPTGWHHYEGTASCYRVYLSGENYWDAAQTCQRLNGSLATFSTDQELRFVLAQEWDQPERSFGWKDQRK
CVGLMNSPIPGSPRSRSGQIARSWPPQAGTTASACSTGGRCSHWPCWPSTAPLSSAWPSPPMACWPRAPRISGSASGHSTHAHDSPTPFP
GDEEGGQGGGHQAPALA

--------------------------------------------------------------
>22405_22405_3_DGCR2-GNB1L_DGCR2_chr22_19052361_ENST00000545799_GNB1L_chr22_19776483_ENST00000329517_length(transcript)=6477nt_BP=740nt
GCGCGCAGCTGGAGTCGGTGCCTGAGGTTGCAGCCGAGAGTGTGCGCCAGCCCGCGGCCCAGCCGAAGCTCTTTCCCGCCGCCTCTCCGC
GCCTCGCCCAGGTTCAGCTCCGCCTGACCCTCCGCTTGGCACGGTCCCCTGACCCTCAGTCCGGCCTGGTCCGGCCTTCCAGCCGCCCCG
GGGACGATGAACGGAGGATAAATGGTGCCCAAGGCAGACAGCGGCGCCTTCCTGCTGCTCTTCCTGCTCGTGCTCACTGTCACCGAGCCG
CTGCGGCCAGAGCTGCGGTGCAACCCTGGGCAGTTTGCGTGTCGCAGCGGCACCATCCAGTGCATCCCCCTCCCCTGGCAGTGTGACGGC
TGGGCGACTTGCGAGGATGAGAGCGACGAAGCCAACTGTCCAGAAGTGACCGGGGAGGTGCGTCCTCATCATGGGAAGGAGGCTGTGGAT
CCGCGGCAGGGGCGGGCCAGAGGAGGCGACCCTTCGCACTTCCACGCGGTGAACGTGGCGCAGCCCGTTCGCTTCAGCAGGAAGTGCCCG
ACAGGGTGGCACCACTACGAAGGCACGGCCAGCTGCTACCGGGTCTACCTGAGCGGGGAGAACTACTGGGATGCCGCGCAGACCTGCCAG
CGCCTGAATGGCTCTCTCGCCACCTTCTCCACTGACCAGGAGCTGCGCTTTGTCCTGGCCCAGGAATGGGACCAGCCCGAGCGGAGCTTT
GGTTGGAAGGACCAGCGCAAGTGCGTGGGACTCATGAACTCACCAATCCCGGGATCGCCGAGGTCACGATCCGGCCAGATCGCAAGATCC
TGGCCACCGCAGGCTGGGACCACCGCATCCGCGTGTTCCACTGGCGGACGATGCAGCCACTGGCCGTGCTGGCCTTCCACAGCGCCGCTG
TCCAGTGCGTGGCCTTCACCGCCGATGGCTTGCTGGCCGCGGGCTCCAAGGATCAGCGGATCAGCCTCTGGTCACTCTACCCACGCGCAT
GACTCACCCACTCCCTTCCCGGGAGACGAGGAGGGCGGGCAGGGAGGTGGGCATCAGGCCCCAGCCTTGGCCTGAAACCTCAAGGGCCTC
TGAGGACCAGCAAGTCATGGCCCAAGGACCATGGAGTCCCCGCTGTCTTCATGAGGTTGGTATTTCCTTTTGTGGAGTGCCTCATCACAG
GACGGTGACTCTGGGGGCCAGCCAGAGCCCTGGCCGTCCGAGGCCTGCAGGAGACGTTGGCTTGGGCCTGCTGTGTTGCCAGCTGAGGGT
ATTTTATAATAAATTTCCATTGCCAAGTTGCAGGCTTGAGGTGGGAGCTCCCTGAGGAGGCCCTGGTCCCCCACTTAGCATCAGTGCCCT
CAGACCCCCACCAGGCAGGATGCTCAGCCCCACCCTCACACCTGCTGTTGAATGGGCCACCCCGAGTGTGGGTTTCCTGGGCCAGGCCTC
AGGAGATGATAGGCCCCAACCATAGCTGCGTCGATGTCCACATGACCCCTCACCCCGAGGAGGCCAGGAGCTCCCAACACACAGGTTGAG
GCCAGGATCAGGATCAGGAAGTAACTGAACTCCCTAAAGAGTGAAGCAGAGAAAGGTGCCTGTGAGGGACGGCAAGGGGGGCTTGCAGCG
CACAGGGCCAGGCCAGATGTGGGATCCGGGAGGGCACGCCTGCCCGCAGAGGGTGCAGTGGGGAAGGCGCACAGGGTGCACCTCCAGGTG
AGTGCTGGGCAGAAGGCACGAGAGCAGCAAGGGAGTGTGACAAGCACCGCCTCACAGTGGCCAAGGCCACAGTCACAGCTGCGGCTGCAC
ACAGGGTGGCCCCCAGGGCACAACACAGCAAGAGCAGGACTTAGCAGCCAGAGCCTCACACTGCATGCAGCCGGGCCCAGCCTGGCCGGT
CGTCTCCTCCTAAAAGCGGGTGTTGATTGGGAAAGAACCATGACCCTGAATATTGGAGTGGGGCCCATGGGCAGATCCAGAGAAGCTGGG
ACCACACACGCCTGTGTCTGCCCGGATTGCCGGAAGAGCCCCTCTAGCTGAAGGCCCGGGGTGGCCTCCCTTGAGGCAGTTGCCCTGCAA
GGCCCTGCCGATGCTCCTTGGGACCCCCACCTGGGCTTCTAGTCCTAGAACTAGACTCGAGTCCAGCAGACCCCCAGGATGAGATACAGA
GGGTGACCCTGAGAGTGGCACCAGCCTCCTGCAGGACCACATGGCATTTCCAGGTTTCCAGGCAGAAATCTGAACATGTGTGGGACGGAT
CGGAAGGGTGTGGGATCCAGGTGGCCGGAGCAGGGGTGGATCAGGGGAGTTCCCGGAACAGACCTGCCAAACGGAGGGCTGGACTGGGCG
CTGCAGCTTGGGGCCAGGAAGGCTCCAGTGCCGGGCTGGGGGTGGGGGCTGGATTACAGCCTGAGGGTGGCTGCACTGAGTGAAGTGGAC
ATGGCCAGCCGCCGTGGGGTACAGCCGAGGAGGGCTTCCAAGGCCTGGGGATGGGGGTGTTGGATTTGTCAGTGAGACCTGTGCACCCAC
TGCAGGGGGTCCCAAGGCCGTGCCTCCCCAACCCCACTGTGAGGAACATGGTTGCTGGGGGGCCCGGAGTCCTTGAGGAGTCCTGTGACC
ACACTTCTCTGTTGGTCAGAGGTACCATGGGGACCGTTCCATCAAACGGGAATGTCAGTGCTGGCCGGGAAAGCGGCCCCTGGCCCAAGC
TTGGAGACCACCTGGCTCGGGTACTGGCCTGGCTCCGTTGGACAAGGGTGGCCACCAGGTGCCCAGGACCTTTGGAGAGGGGGGCCCTGC
TGCTTTTCCTCGAGTGTCCTATAGCCGCCAGGATGCGTAGGGCACTCCGGGAGGTATTTTCATATCACTGAGGTGTCAGGGAGGGGAAGG
GTCCTGGGTTTAGGCTGCAGTGACTGCAGGTGCTGAGGGAGCTGTGCCCTGGGTGCTCATCACAGGCTGTCACAGTGAGGGAAGGTGTCA
GGTTCTGACATCCCCATGACAGCGGCAGGGTAGGTGGAGTGGGAATTGGCTTTGCAGTTTCCCTGCATGCCCTTGACAGCCTTGCCAAAG
GCACATCTGCCCCGCCTCAGCTCCCACCCTGAGGGTTCTGGGCCTCTACCCCTTCCCCTGTTTATGTCCCTGTCATCTTTGGCATCATCA
CTGTAGTTACAAAACTCCCTACGTCCCACAGCCACGAGGTGGGTATCCCACATGAGGGCCCAGGTGTGCATGCCAGCATGAGGTTGGCGA
GTGGCACTGCCTGCTGATGTCTTACATAGAGGCCATGAAGAGCTGTGGGCAGGGTGTACAGACCCTGAGTTGGCCCCTGGCCCTCGTGCT
TTCAGTCAAAGGCACAAGCAGGGTGGATGGCAGGCGGCTGCCCCCTAGCCTGGCCTTGAGCTCCCTGCCCCAGGCCATGTGGCGTTGAGC
AGTGTCCAGGCACATCTTGTTCTGAATCTCAGTGTGCAGGGATGGAGTCGGGACAGCGTGAGTCCTGCATGCCTAACACAGCCCTCACCC
CTCCAGTGCACAACGGGGCCACGTGCCCGCATCTGGGTGGCTAGGCAGATAGGGCCCCCCTTGCCAGGCAGATCCAGCTTCTGAGGCCTT
ATAGACGTCCTGTGGAGGGCAGGCCCAGGACTTTCATTCACCTGGCTGAGCTGCCTGGGAGAGCAGCAGAACCGGTGCTGGGGTCCAAGC
CGGCCAAGAGCAGTGCAGCCCTCCTGGTCCTGTTCCTCTCTTGAGCTGCTCCGTGGTGTCCACAGCAGAGCCATGTGGCTCTGGACAGGT
CGGCCTTTGTGTCAACAGAACCTGGGTCGTGATGAATCACCATGCGTCTGACCAGCCTTGAAACCCCCACAACAGAAGAAGAAACGGTCT
CAGCTCCAGACATCCAGCTTGGAAAAGATGCACCTGAACATTGGCATTCTCTTCCTAGCAAACAGCCACTTCCTGTAGGCTGGCAGGAAC
GCCAACAGAGCCAGCAGTGAAGGCATTAAGTGGGGAGGAGGGGTGGCCCGGAGGCAGCACGCGAAGGTCAGCATGCAGCTCCTGGGATGA
ACCTGAGAGGCGACTCCTGGCAGCATGGCTGGTCGCTGCCATCACGCCCCTGGCCAACCCACCAACTGGGAGAGGCAGCCCTTCCACATC
TTCCTCCATAATGCTCTTGGGTAGCAGTGAGGCCTCTCAAGCCAGAGAGAACTTGGTGTTTGGAAACAACGGCGGACATTTCTTGCCATT
TTCAGTGCCAACTCAGGTAGGTGTGTTCTACCATCCTGTGTTTTTGGGGTGTTTTTTTTTTTGAGTCAGAGTCTCACTCTGTCCCCCAGG
CTGGAGTGCAATGGAGCAGTCTCGGCTCACTGCAACCTCTGATTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGAAGCTCAG
GACCACCCACATAGGTGCAGGCCATCATGCCCAGCTAATTTTTTATTTTTTTTTATAGAGAAGGAGTCTCGCTATGTTGCCCAGGCTGGT
TTCGAACTCCTGGGCTCAAGCGATCGATCCTCCCGCCTCTAGCCTCCCAAAGCACTAGAATTATAGGCCTGAGCCACTGCGCCCGGCCCA
CCATCCTGTTCTTATTGGAAGAATTTCCATGTGTCGAGGCACGGGCACAACGTAGCTGGTCCTCTGCTCAGGGCCCCACAAGGCTGCGTC
AGGGTGGCAGCGCGGCTGGGGGCTTTTTCTGTTCAAATCCAGATTCTCGTGGCTGTGAGCCCCAGCCCTGGGCACTGTCCGCCTGGTGGT
GTCTTCACAGCCAGCAGGGGTGGCCTTGGGGTGTTCTGTGGAGTAACTTTCACGGCCCAGAGTGGGATCCTGAGTGGCTGGAGCCGTATG
CTCCAGCATCCCCAGCCGCTGCCTCCGGTGCAGGTGGAGTGGGCCCCTCTGATTACCAGGAGCTGTCAGAGGGGCAGCAGGTCCCACTCC
ACTGGCCGGTGGGCAGCTGTGTGCAGGGACGCGGGTCCTGGCACGTCTGCCTGGTGAGGCCCTGCCTCCAGTGCCAAGGGGCCTCCCCTC
TCGACGGTGGGCGCCACCATGTGCTGACCTCTGTGCAGCCCCACTTTACAAGGTAGGTTCGGCCAGCACCCCATCCGCGGGCGGGCAGCA
CTCACCCAGCGTTGCGCCGCCAACAGGGTCCCTCTTAGACAAGCAGCTGTGCCTAGAGCCTTTTCCTTCCTCCCTGCGTGTTACCTGCAG
GCCAACAGACGGCCCTGGGTCTGGGACCAGGAGAACCTGCCTCCGCCTCTGGCAGTGGGTGTCCCTGCAGGCAGATTGGGCTTGGCACGT
AGACACCGAGGGGTCAGCCGATGCCGGGAGATGATCCCGGGAAGGGCTCCGGAGCACAGCCCAGGACCCGCCGCCGCTGCTGGGCGCTCC
ATGTTGACGTGCTGTGCGTGTCTCCACTCCCCAGGCAATGATGTTCAATCAGGTGTTTCCCACCTGTGTCTCTGCCAAGAAGCCACAGAA
CACCCTCTGCACAAAAGGAGTGTTTGCACAAAGAAAAACAACCCTCCGGGGGTTCTTTAGAAATGCTTATACTCAATTAGCTAGAACTTC
ATGTGAAATCCCAGCGTGGAAGACAACAAGCCGGCACCGGTGAAAACTTTGCTGTGCACCTGCCCTCTACCAAGCTGCCAGCCCCACCAG
CCCTGTGGTCCTAGGTGGGCACAGCTGCTGCACGGTCCCCCAGGCCTGCCTCTCCTCGGGGTCTCAACCTTCATACCAGATTTGCCAGCA
TCCCCATTCCCGCCTTGTGGGTGGAGAGTCCTTGAGACCCTCTGTCACTCTGTCAGCTTCCCCAGGTCAGCGAGCTGTGGCTTGGCTCCC
ACGCATCAGCTTTTATGGGAGGCCCATTAGGAGCTGGGCAGGAGGGACAGAGGGGAGGCCAGGCAGCCACTGCTGAGTGGGACGGGTAGC
CCAGCCCATGAGGCTGGCCAGCCCTACAGGGGAGGTCCCACAGCACTGGCCGGGAAGTCCACATAGGAAAGCATCAGTTGAGGGATGAAG
CCACGGACGATGGGGACAACGGCCACAGGGTGTGCTAAGCTGAGGAAATTAGTAGGAGGTGCTCATAAGCTGTTTTGTTTTTTGGTTTGT
TTGTTTGTTTTTTCTTTTAAGAGACCAGGGACAGTGGGGGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCATGATCATAGCTTACT
GCAGCCTCCAACTAATAGGCTCAAGTGATCCTCCTGCCTCAGCCTCCCGAGTAACTCATGGCCTTTAAGTGAACTGCTTCCACCATCCAG
CTGTGCAGGTGGCCTGGGAACAGCAGCACATCTGTCCCCTGCCACCTCTTGCATGCACACTTGACCTCCTGACTTGGGCTCTGAAACCTG
TAAAATGTGGGGTGTAGAGAAATCGAGTCATTTGGCCTCATCCTGGTGCCATTATCTCTTGCTACATTAATAAACCACCTCAAACAG

>22405_22405_3_DGCR2-GNB1L_DGCR2_chr22_19052361_ENST00000545799_GNB1L_chr22_19776483_ENST00000329517_length(amino acids)=287AA_BP=180
MVPKADSGAFLLLFLLVLTVTEPLRPELRCNPGQFACRSGTIQCIPLPWQCDGWATCEDESDEANCPEVTGEVRPHHGKEAVDPRQGRAR
GGDPSHFHAVNVAQPVRFSRKCPTGWHHYEGTASCYRVYLSGENYWDAAQTCQRLNGSLATFSTDQELRFVLAQEWDQPERSFGWKDQRK
CVGLMNSPIPGSPRSRSGQIARSWPPQAGTTASACSTGGRCSHWPCWPSTAPLSSAWPSPPMACWPRAPRISGSASGHSTHAHDSPTPFP
GDEEGGQGGGHQAPALA

--------------------------------------------------------------
>22405_22405_4_DGCR2-GNB1L_DGCR2_chr22_19052361_ENST00000545799_GNB1L_chr22_19776483_ENST00000403325_length(transcript)=1286nt_BP=740nt
GCGCGCAGCTGGAGTCGGTGCCTGAGGTTGCAGCCGAGAGTGTGCGCCAGCCCGCGGCCCAGCCGAAGCTCTTTCCCGCCGCCTCTCCGC
GCCTCGCCCAGGTTCAGCTCCGCCTGACCCTCCGCTTGGCACGGTCCCCTGACCCTCAGTCCGGCCTGGTCCGGCCTTCCAGCCGCCCCG
GGGACGATGAACGGAGGATAAATGGTGCCCAAGGCAGACAGCGGCGCCTTCCTGCTGCTCTTCCTGCTCGTGCTCACTGTCACCGAGCCG
CTGCGGCCAGAGCTGCGGTGCAACCCTGGGCAGTTTGCGTGTCGCAGCGGCACCATCCAGTGCATCCCCCTCCCCTGGCAGTGTGACGGC
TGGGCGACTTGCGAGGATGAGAGCGACGAAGCCAACTGTCCAGAAGTGACCGGGGAGGTGCGTCCTCATCATGGGAAGGAGGCTGTGGAT
CCGCGGCAGGGGCGGGCCAGAGGAGGCGACCCTTCGCACTTCCACGCGGTGAACGTGGCGCAGCCCGTTCGCTTCAGCAGGAAGTGCCCG
ACAGGGTGGCACCACTACGAAGGCACGGCCAGCTGCTACCGGGTCTACCTGAGCGGGGAGAACTACTGGGATGCCGCGCAGACCTGCCAG
CGCCTGAATGGCTCTCTCGCCACCTTCTCCACTGACCAGGAGCTGCGCTTTGTCCTGGCCCAGGAATGGGACCAGCCCGAGCGGAGCTTT
GGTTGGAAGGACCAGCGCAAGTGCGTGGGACTCATGAACTCACCAATCCCGGGATCGCCGAGGTCACGATCCGGCCAGATCGCAAGATCC
TGGCCACCGCAGGCTGGGACCACCGCATCCGCGTGTTCCACTGGCGGACGATGCAGCCACTGGCCGTGCTGGCCTTCCACAGCGCCGCTG
TCCAGTGCGTGGCCTTCACCGCCGATGGCTTGCTGGCCGCGGGCTCCAAGGATCAGCGGATCAGCCTCTGGTCACTCTACCCACGCGCAT
GACTCACCCACTCCCTTCCCGGGAGACGAGGAGGGCGGGCAGGGAGGTGGGCATCAGGCCCCAGCCTTGGCCTGAAACCTCAAGGGCCTC
TGAGGACCAGCAAGTCATGGCCCAAGGACCATGGAGTCCCCGCTGTCTTCATGAGGTTGGTATTTCCTTTTGTGGAGTGCCTCATCACAG
GACGGTGACTCTGGGGGCCAGCCAGAGCCCTGGCCGTCCGAGGCCTGCAGGAGACGTTGGCTTGGGCCTGCTGTGTTGCCAGCTGAGGGT
ATTTTATAATAAATTTCCATTGCCAA

>22405_22405_4_DGCR2-GNB1L_DGCR2_chr22_19052361_ENST00000545799_GNB1L_chr22_19776483_ENST00000403325_length(amino acids)=287AA_BP=180
MVPKADSGAFLLLFLLVLTVTEPLRPELRCNPGQFACRSGTIQCIPLPWQCDGWATCEDESDEANCPEVTGEVRPHHGKEAVDPRQGRAR
GGDPSHFHAVNVAQPVRFSRKCPTGWHHYEGTASCYRVYLSGENYWDAAQTCQRLNGSLATFSTDQELRFVLAQEWDQPERSFGWKDQRK
CVGLMNSPIPGSPRSRSGQIARSWPPQAGTTASACSTGGRCSHWPCWPSTAPLSSAWPSPPMACWPRAPRISGSASGHSTHAHDSPTPFP
GDEEGGQGGGHQAPALA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DGCR2-GNB1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DGCR2-GNB1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DGCR2-GNB1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDGCR2C0036341Schizophrenia1CTD_human
TgeneC0036341Schizophrenia4PSYGENET
TgeneC0033975Psychotic Disorders2PSYGENET
TgeneC0005586Bipolar Disorder1PSYGENET
TgeneC0349204Nonorganic psychosis1PSYGENET