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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDH1-TRHDE (FusionGDB2 ID:HG999TG29953)

Fusion Gene Summary for CDH1-TRHDE

check button Fusion gene summary
Fusion gene informationFusion gene name: CDH1-TRHDE
Fusion gene ID: hg999tg29953
HgeneTgene
Gene symbol

CDH1

TRHDE

Gene ID

999

29953

Gene namecadherin 1thyrotropin releasing hormone degrading enzyme
SynonymsArc-1|BCDS1|CD324|CDHE|ECAD|LCAM|UVOPAP-II|PGPEP2|TRH-DE
Cytomap('CDH1')('TRHDE')

16q22.1

12q21.1

Type of geneprotein-codingprotein-coding
Descriptioncadherin-1CAM 120/80E-cadherin 1cadherin 1, E-cadherin (epithelial)cadherin 1, type 1, E-cadherin (epithelial)calcium-dependent adhesion protein, epithelialcell-CAM 120/80epididymis secretory sperm binding proteinepithelial cadherinuvomorulinthyrotropin-releasing hormone-degrading ectoenzymeTRH-degrading ectoenzymeTRH-specific aminopeptidasepyroglutamyl aminopeptidase IIpyroglutamyl-peptidase IIthyroliberinase
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000562836, ENST00000261769, 
ENST00000422392, 
Fusion gene scores* DoF score21 X 16 X 8=268819 X 12 X 7=1596
# samples 2921
** MAII scorelog2(29/2688*10)=-3.21240833276383
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/1596*10)=-2.92599941855622
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDH1 [Title/Abstract] AND TRHDE [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDH1(68835796)-TRHDE(72771775), # samples:3
Anticipated loss of major functional domain due to fusion event.CDH1-TRHDE seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH1-TRHDE seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH1-TRHDE seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH1-TRHDE seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDH1

GO:0042307

positive regulation of protein import into nucleus

16338932

HgeneCDH1

GO:0045893

positive regulation of transcription, DNA-templated

16338932

HgeneCDH1

GO:0071285

cellular response to lithium ion

12937339

HgeneCDH1

GO:0071681

cellular response to indole-3-methanol

10868478

HgeneCDH1

GO:0072659

protein localization to plasma membrane

17620337

HgeneCDH1

GO:0098609

cell-cell adhesion

16338932|18593713


check buttonFusion gene breakpoints across CDH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TRHDE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-VP-A879-01ACDH1chr16

68835796

-TRHDEchr12

72771775

+
ChimerDB4PRADTCGA-VP-A879-01ACDH1chr16

68835796

+TRHDEchr12

72771775

+
ChimerDB4PRADTCGA-VP-A879CDH1chr16

68835796

+TRHDEchr12

72771774

+
ChimerDB4PRADTCGA-VP-A879CDH1chr16

68835796

+TRHDEchr12

72771775

+


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Fusion Gene ORF analysis for CDH1-TRHDE

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000562836ENST00000261180CDH1chr16

68835796

+TRHDEchr12

72771775

+
3UTR-3CDSENST00000562836ENST00000261180CDH1chr16

68835796

+TRHDEchr12

72771774

+
3UTR-intronENST00000562836ENST00000549138CDH1chr16

68835796

+TRHDEchr12

72771775

+
3UTR-intronENST00000562836ENST00000549138CDH1chr16

68835796

+TRHDEchr12

72771774

+
5CDS-intronENST00000261769ENST00000549138CDH1chr16

68835796

+TRHDEchr12

72771775

+
5CDS-intronENST00000261769ENST00000549138CDH1chr16

68835796

+TRHDEchr12

72771774

+
5CDS-intronENST00000422392ENST00000549138CDH1chr16

68835796

+TRHDEchr12

72771775

+
5CDS-intronENST00000422392ENST00000549138CDH1chr16

68835796

+TRHDEchr12

72771774

+
In-frameENST00000261769ENST00000261180CDH1chr16

68835796

+TRHDEchr12

72771775

+
In-frameENST00000261769ENST00000261180CDH1chr16

68835796

+TRHDEchr12

72771774

+
In-frameENST00000422392ENST00000261180CDH1chr16

68835796

+TRHDEchr12

72771775

+
In-frameENST00000422392ENST00000261180CDH1chr16

68835796

+TRHDEchr12

72771774

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261769CDH1chr1668835796+ENST00000261180TRHDEchr1272771775+5047578412599852
ENST00000422392CDH1chr1668835796+ENST00000261180TRHDEchr1272771775+4920451642472802
ENST00000261769CDH1chr1668835796+ENST00000261180TRHDEchr1272771774+5047578412599852
ENST00000422392CDH1chr1668835796+ENST00000261180TRHDEchr1272771774+4920451642472802

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261769ENST00000261180CDH1chr1668835796+TRHDEchr1272771775+3.44E-050.99996555
ENST00000422392ENST00000261180CDH1chr1668835796+TRHDEchr1272771775+3.16E-050.9999684
ENST00000261769ENST00000261180CDH1chr1668835796+TRHDEchr1272771774+3.44E-050.99996555
ENST00000422392ENST00000261180CDH1chr1668835796+TRHDEchr1272771774+3.16E-050.9999684

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Fusion Genomic Features for CDH1-TRHDE


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CDH1chr1668835796+TRHDEchr1272771774+0.0018551930.99814487
CDH1chr1668835796+TRHDEchr1272771774+0.0018551930.99814487
CDH1chr1668835796+TRHDEchr1272771774+0.0018551930.99814487
CDH1chr1668835796+TRHDEchr1272771774+0.0018551930.99814487

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CDH1-TRHDE


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:68835796/chr12:72771775)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTRHDEchr16:68835796chr12:72771774ENST00000261180119404_4083511025.0RegionSubstrate binding
TgeneTRHDEchr16:68835796chr12:72771775ENST00000261180119404_4083511025.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDH1chr16:68835796chr12:72771774ENST00000261769+316838_851129883.0Compositional biasNote=Ser-rich
HgeneCDH1chr16:68835796chr12:72771775ENST00000261769+316838_851129883.0Compositional biasNote=Ser-rich
HgeneCDH1chr16:68835796chr12:72771774ENST00000261769+316155_262129883.0DomainCadherin 1
HgeneCDH1chr16:68835796chr12:72771774ENST00000261769+316263_375129883.0DomainCadherin 2
HgeneCDH1chr16:68835796chr12:72771774ENST00000261769+316376_486129883.0DomainCadherin 3
HgeneCDH1chr16:68835796chr12:72771774ENST00000261769+316487_593129883.0DomainCadherin 4
HgeneCDH1chr16:68835796chr12:72771774ENST00000261769+316594_697129883.0DomainCadherin 5
HgeneCDH1chr16:68835796chr12:72771775ENST00000261769+316155_262129883.0DomainCadherin 1
HgeneCDH1chr16:68835796chr12:72771775ENST00000261769+316263_375129883.0DomainCadherin 2
HgeneCDH1chr16:68835796chr12:72771775ENST00000261769+316376_486129883.0DomainCadherin 3
HgeneCDH1chr16:68835796chr12:72771775ENST00000261769+316487_593129883.0DomainCadherin 4
HgeneCDH1chr16:68835796chr12:72771775ENST00000261769+316594_697129883.0DomainCadherin 5
HgeneCDH1chr16:68835796chr12:72771774ENST00000261769+316758_769129883.0RegionNote=Required for binding CTNND1 and PSEN1
HgeneCDH1chr16:68835796chr12:72771774ENST00000261769+316811_882129883.0RegionNote=Required for binding alpha%2C beta and gamma catenins
HgeneCDH1chr16:68835796chr12:72771775ENST00000261769+316758_769129883.0RegionNote=Required for binding CTNND1 and PSEN1
HgeneCDH1chr16:68835796chr12:72771775ENST00000261769+316811_882129883.0RegionNote=Required for binding alpha%2C beta and gamma catenins
HgeneCDH1chr16:68835796chr12:72771774ENST00000261769+316155_709129883.0Topological domainExtracellular
HgeneCDH1chr16:68835796chr12:72771774ENST00000261769+316731_882129883.0Topological domainCytoplasmic
HgeneCDH1chr16:68835796chr12:72771775ENST00000261769+316155_709129883.0Topological domainExtracellular
HgeneCDH1chr16:68835796chr12:72771775ENST00000261769+316731_882129883.0Topological domainCytoplasmic
HgeneCDH1chr16:68835796chr12:72771774ENST00000261769+316710_730129883.0TransmembraneHelical
HgeneCDH1chr16:68835796chr12:72771775ENST00000261769+316710_730129883.0TransmembraneHelical
TgeneTRHDEchr16:68835796chr12:72771774ENST000002611801191_403511025.0Topological domainCytoplasmic
TgeneTRHDEchr16:68835796chr12:72771774ENST0000026118011962_10243511025.0Topological domainExtracellular
TgeneTRHDEchr16:68835796chr12:72771775ENST000002611801191_403511025.0Topological domainCytoplasmic
TgeneTRHDEchr16:68835796chr12:72771775ENST0000026118011962_10243511025.0Topological domainExtracellular
TgeneTRHDEchr16:68835796chr12:72771774ENST0000026118011941_613511025.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTRHDEchr16:68835796chr12:72771775ENST0000026118011941_613511025.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for CDH1-TRHDE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15044_15044_1_CDH1-TRHDE_CDH1_chr16_68835796_ENST00000261769_TRHDE_chr12_72771774_ENST00000261180_length(transcript)=5047nt_BP=578nt
AGCCAATCAGCGGTACGGGGGGCGGTGCCTCCGGGGCTCACCTGGCTGCAGCCACGCACCCCCTCTCAGTGGCGTCGGAACTGCAAAGCA
CCTGTGAGCTTGCGGAAGTCAGTTCAGACTCCAGCCCGCTCCAGCCCGGCCCGACCCGACCGCACCCGGCGCCTGCCCTCGCTCGGCGTC
CCCGGCCAGCCATGGGCCCTTGGAGCCGCAGCCTCTCGGCGCTGCTGCTGCTGCTGCAGGTCTCCTCTTGGCTCTGCCAGGAGCCGGAGC
CCTGCCACCCTGGCTTTGACGCCGAGAGCTACACGTTCACGGTGCCCCGGCGCCACCTGGAGAGAGGCCGCGTCCTGGGCAGAGTGAATT
TTGAAGATTGCACCGGTCGACAAAGGACAGCCTATTTTTCCCTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGATTACAGTCAAAA
GGCCTCTACGGTTTCATAACCCACAGATCCATTTCTTGGTCTACGCCTGGGACTCCACCTACAGAAAGTTTTCCACCAAAGTCACGCTGA
ATACAGTGGGGCACCACCACCGCCCCCCGCCCCATCAGGTACGATTATATGCAAGACCTGATGCTATCAGAAGAGGATCCGGGGACTATG
CTCTCCATATAACAAAGAGATTAATAGAATTTTATGAAGACTACTTTAAAGTGCCCTATTCCTTGCCAAAACTAGATCTTTTAGCTGTGC
CTAAGCATCCGTATGCTGCTATGGAGAACTGGGGACTAAGTATTTTTGTGGAACAAAGAATACTGCTGGATCCCAGTGTTTCATCTATTT
CTTATTTGCTGGATGTCACCATGGTCATTGTTCATGAGATATGTCACCAGTGGTTTGGTGACCTTGTGACGCCTGTGTGGTGGGAAGACG
TGTGGCTGAAGGAAGGGTTTGCTCACTACTTTGAATTTGTTGGTACAGACTACCTCTATCCTGGCTGGAACATGGAAAAGCAGAGGTTTC
TGACCGATGTTCTGCATGAAGTGATGCTGCTGGACGGTTTGGCCAGTTCCCATCCAGTATCACAGGAAGTGCTGCAGGCAACAGATATTG
ACAGGGTGTTTGACTGGATCGCATATAAAAAGGGTGCTGCTTTAATAAGAATGCTGGCTAATTTTATGGGCCATTCAGTTTTCCAGAGGG
GTTTGCAAGATTATTTAACCATTCATAAGTATGGTAATGCAGCCAGAAATGATCTCTGGAATACATTATCGGAGGCTTTAAAAAGAAATG
GGAAATATGTAAATATACAAGAAGTAATGGATCAGTGGACACTCCAGATGGGTTATCCTGTTATCACCATCTTGGGAAACACAACAGCAG
AAAATAGAATAATAATTACCCAACAGCATTTTATCTATGATATCAGTGCTAAAACTAAAGCACTTAAACTTCAGAATAACAGTTACCTGT
GGCAGATTCCATTAACTATTGTGGTAGGAAATAGAAGCCATGTGTCTTCAGAAGCAATTATTTGGGTGTCTAACAAATCAGAGCACCACA
GAATAACTTATTTGGACAAAGGAAGCTGGCTGCTGGGGAACATCAATCAAACTGGCTATTTTAGAGTCAACTATGACCTAAGGAACTGGA
GATTATTAATTGATCAATTAATCCGGAATCATGAGGTTCTTTCTGTCAGTAACCGAGCGGGCTTGATCGATGATGCCTTCAGCCTAGCCA
GGGCTGGCTATTTGCCTCAGAATATTCCTCTGGAGATTATCAGATACCTGTCTGAGGAGAAGGATTTTCTTCCTTGGCATGCTGCCAGCC
GAGCTCTTTATCCTCTAGATAAATTACTGGACCGCATGGAAAACTACAACATTTTCAATGAATATATTTTAAAGCAAGTTGCAACAACAT
ATATCAAGCTTGGGTGGCCGAAAAATAATTTTAATGGATCTCTTGTTCAAGCATCCTACCAACATGAAGAACTACGTAGAGAAGTTATAA
TGCTGGCCTGCAGTTTTGGCAACAAGCACTGTCACCAACAGGCATCAACACTTATTTCAGATTGGATTTCCAGCAACAGGAACAGAATAC
CACTAAATGTTAGAGACATCGTATACTGTACAGGAGTGTCACTACTGGATGAGGATGTCTGGGAATTCATATGGATGAAATTCCATTCCA
CCACAGCAGTTTCTGAGAAGAAAATATTATTGGAAGCCTTAACTTGCAGTGATGACAGGAATTTATTAAACAGGCTTCTAAATCTGTCAC
TGAATTCTGAGGTGGTGCTGGATCAAGATGCAATTGATGTCATAATCCATGTAGCTCGAAATCCACATGGTCGAGACCTTGCCTGGAAGT
TTTTCAGGGATAAATGGAAGATATTAAATACCAGGTATGGAGAAGCATTGTTTATGAATTCCAAACTCATCAGTGGTGTCACAGAATTTC
TTAATACTGAAGGTGAACTCAAAGAGCTCAAGAACTTCATGAAAAACTATGATGGGGTAGCTGCTGCTTCTTTCTCACGAGCTGTGGAAA
CTGTCGAAGCCAATGTGCGCTGGAAAATGCTTTACCAAGACGAGCTTTTCCAATGGTTAGGAAAAGCTCTAAGACACTAATATATGTATC
TTATAAACAAACAATTCAACTCAGAAGTTTATGAGAAGACACGCTTTTTGTGGAATGAGGAAAATGTACTACCTAGAAAATGGCCAGATT
TTCAGTGTTAACGTGTGGGAGGAATTTTTTTTTTAGTTTTTATTTTTTGGTTTTGGGGGATATTTTTTATTTGTTTCATTCATTCTGTTC
TGTTTCTCTACTGGGTGTTCCTCTCTAAAGAAACTCTTGCAAGTGAAACTAGCCATGATTGCTTCAGCTGTACATTCCTTGCTGTACAGG
ACCAAATATGATAGTGATGCATGTTGATGTTACAGTCAATTTGGAAAAACATATTCAGAATATCTGTGCATGGATATATTGTCCTGCCTG
TGTTCCAGCATGCTTATTTCAAACGTCCAGTGTTGTGTGTGAATATGTGTTACACCTAGGATGGGCATTATGCAAAAGCACAAAGATTAT
ATATGACAATCAGTATTGCAATGAAAGAAAAACTAAAAACAGAAATGATATTCTCAATTTTGGGCAATGTGAGAGGTAAAATAGCCCTTG
ACATGATGAACATCACTTATTTCAGCACTTGGATTGTCTGGCAATGATTACTGTGTTGCTAACTCATTTTCTTTGAGTTAAAGCTGTGTA
TACATTTTAAAAGGCATATAGATAGTGTATGCATATGTATATGTACATAGGGAAGCCCCATATGTATATAGTATGTTGTACACTGCACAT
GTACAAAGAATGTCTTCAGATCAAAGAAAATTTATCTCTTTTTATAAACTTAAGGACAGTTGCAAAAGGCTTCAAGGAATTTATCTCAAC
ATTATTCTTTCTATGTCCTAACTAAATTTCTCAACTGTTATGAATTTTTCATCTACTTCTTGAACAGTGGTCTATTCTGCTACATGAAGA
TGAATACAAACAAAATTTTTGTATAAACTACTATTCCAGTTCTCCTGTGTCAGTCTTGCCTATAGATTTTGCCATCGTTTTCTGTCAAAG
TTCCTTTTGCATGAAACAATTATGCAAACTTATAATTATTAGTGCTGAAAAAGAGTTTATTTTCCATCTTGTTTGTTTTCCTACCTTATG
CTGAGTAGTCCAGAGAGTTAAAAAAATTCTCTGCATGTTGGTCTTTTAAGTCTGTTTTGCTCTAATCCTCCATTAAGCGAGCATACCTCA
AGTGGGTCTATTAGCATTTAATGACCTTTTGTGCCAGTTGTGCCATCCCTTAAGATGAAAAGTTCCTTTTCTTGTGTTAATGTACAAAGC
TTTTCTTTTGGCACTGACAACTGTGTTCTACCTGGGAATTTTGAATAGCCATTTTCATGGCTGTGTGTTGTGTAACACAAATGTTTTTAA
ATGGTATTCTCACCCAGTAGGCCAGCTCTCCAAACGTTGCTTAGATGCTTCAAAATTAGCATATTTTAAGTTTACCAGTATAAAATACCA
ATGCAACTACTCTACATAGCCAAATGTTTGTAAATCACGTCTTATTTTCCTGAGGTTTTTCACTCCACCAAATCTTACAAATCATTGAAA
GAAATATATTCTAACAGTACGCACTGAATAGTGAAAATAATTAGACATTTTAAGAACCAGAGCCATAGAATTATTTTAAATTAGTAGAAA
AGAGGAGCTATTTCCGAATCTATAGAATAAAGTACCACCTAAAACTGAATTTTATCATATAAGCAAGTAATACCTATTAGTCATACCTAA
ATTTTTCAGCACTTCATTCAATTAAAATACATGAATTTTAAATATTTTACATGATGTGAATAGGCATGATAATACTTTTAGTATAAAATC
TAAACTTTTTCCATTTATCAGAAATGATAAAATCCAGTTACCACATATCACGTTTATAAAATCCTTAATTAAATGAGTAACTTCTAAAAT
ATAACAATACTAAATATCACACTGCGATGGAGGTCCCAAATATGTGGTCTATCACCACTGAATTCATGTAATAGATAAGAAAAAAATTAG
AGGTGGATGTCTTGTTTTGTGTCATGAATTACTAAAATCTCTTAGTAGTTGTGGTATATTTTTGAGTAAAATTACCATTTCCAGATTTGA
GTTTGAAGGGCTTTTATAGTTGTATTTTCCTCCTCACTGTTAATAATCATAATCCTTTTTCAGTATTTTAGTGGCCTTGAACAACTGGTT
TATCTACAATCTCAAATCCTAAGTGTATAATTATGTGCAATGTTCAATACCTCATATAATACTTGCTCAACAGTATAGTGGTACCAATGG
CATTAAGATGGTGTTTTTGTTCTACATATTTTTCAATAATTTATTCTTTCTAATGTTGAAATTATATCAGGCTTTACCGGTTTTTTTAGT
TGTTTAAATAAGTAATATTTTCAAAAGAATAAAATAACCAATGATATCTCTTGGAATAATCTGTAAAACGTAGTTATAAAATTCTATTTT

>15044_15044_1_CDH1-TRHDE_CDH1_chr16_68835796_ENST00000261769_TRHDE_chr12_72771774_ENST00000261180_length(amino acids)=852AA_BP=179
MAAATHPLSVASELQSTCELAEVSSDSSPLQPGPTRPHPAPALARRPRPAMGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFT
VPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQV
RLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEI
CHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAA
LIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYD
ISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVL
SVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGS
LVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEAL
TCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFM

--------------------------------------------------------------
>15044_15044_2_CDH1-TRHDE_CDH1_chr16_68835796_ENST00000261769_TRHDE_chr12_72771775_ENST00000261180_length(transcript)=5047nt_BP=578nt
AGCCAATCAGCGGTACGGGGGGCGGTGCCTCCGGGGCTCACCTGGCTGCAGCCACGCACCCCCTCTCAGTGGCGTCGGAACTGCAAAGCA
CCTGTGAGCTTGCGGAAGTCAGTTCAGACTCCAGCCCGCTCCAGCCCGGCCCGACCCGACCGCACCCGGCGCCTGCCCTCGCTCGGCGTC
CCCGGCCAGCCATGGGCCCTTGGAGCCGCAGCCTCTCGGCGCTGCTGCTGCTGCTGCAGGTCTCCTCTTGGCTCTGCCAGGAGCCGGAGC
CCTGCCACCCTGGCTTTGACGCCGAGAGCTACACGTTCACGGTGCCCCGGCGCCACCTGGAGAGAGGCCGCGTCCTGGGCAGAGTGAATT
TTGAAGATTGCACCGGTCGACAAAGGACAGCCTATTTTTCCCTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGATTACAGTCAAAA
GGCCTCTACGGTTTCATAACCCACAGATCCATTTCTTGGTCTACGCCTGGGACTCCACCTACAGAAAGTTTTCCACCAAAGTCACGCTGA
ATACAGTGGGGCACCACCACCGCCCCCCGCCCCATCAGGTACGATTATATGCAAGACCTGATGCTATCAGAAGAGGATCCGGGGACTATG
CTCTCCATATAACAAAGAGATTAATAGAATTTTATGAAGACTACTTTAAAGTGCCCTATTCCTTGCCAAAACTAGATCTTTTAGCTGTGC
CTAAGCATCCGTATGCTGCTATGGAGAACTGGGGACTAAGTATTTTTGTGGAACAAAGAATACTGCTGGATCCCAGTGTTTCATCTATTT
CTTATTTGCTGGATGTCACCATGGTCATTGTTCATGAGATATGTCACCAGTGGTTTGGTGACCTTGTGACGCCTGTGTGGTGGGAAGACG
TGTGGCTGAAGGAAGGGTTTGCTCACTACTTTGAATTTGTTGGTACAGACTACCTCTATCCTGGCTGGAACATGGAAAAGCAGAGGTTTC
TGACCGATGTTCTGCATGAAGTGATGCTGCTGGACGGTTTGGCCAGTTCCCATCCAGTATCACAGGAAGTGCTGCAGGCAACAGATATTG
ACAGGGTGTTTGACTGGATCGCATATAAAAAGGGTGCTGCTTTAATAAGAATGCTGGCTAATTTTATGGGCCATTCAGTTTTCCAGAGGG
GTTTGCAAGATTATTTAACCATTCATAAGTATGGTAATGCAGCCAGAAATGATCTCTGGAATACATTATCGGAGGCTTTAAAAAGAAATG
GGAAATATGTAAATATACAAGAAGTAATGGATCAGTGGACACTCCAGATGGGTTATCCTGTTATCACCATCTTGGGAAACACAACAGCAG
AAAATAGAATAATAATTACCCAACAGCATTTTATCTATGATATCAGTGCTAAAACTAAAGCACTTAAACTTCAGAATAACAGTTACCTGT
GGCAGATTCCATTAACTATTGTGGTAGGAAATAGAAGCCATGTGTCTTCAGAAGCAATTATTTGGGTGTCTAACAAATCAGAGCACCACA
GAATAACTTATTTGGACAAAGGAAGCTGGCTGCTGGGGAACATCAATCAAACTGGCTATTTTAGAGTCAACTATGACCTAAGGAACTGGA
GATTATTAATTGATCAATTAATCCGGAATCATGAGGTTCTTTCTGTCAGTAACCGAGCGGGCTTGATCGATGATGCCTTCAGCCTAGCCA
GGGCTGGCTATTTGCCTCAGAATATTCCTCTGGAGATTATCAGATACCTGTCTGAGGAGAAGGATTTTCTTCCTTGGCATGCTGCCAGCC
GAGCTCTTTATCCTCTAGATAAATTACTGGACCGCATGGAAAACTACAACATTTTCAATGAATATATTTTAAAGCAAGTTGCAACAACAT
ATATCAAGCTTGGGTGGCCGAAAAATAATTTTAATGGATCTCTTGTTCAAGCATCCTACCAACATGAAGAACTACGTAGAGAAGTTATAA
TGCTGGCCTGCAGTTTTGGCAACAAGCACTGTCACCAACAGGCATCAACACTTATTTCAGATTGGATTTCCAGCAACAGGAACAGAATAC
CACTAAATGTTAGAGACATCGTATACTGTACAGGAGTGTCACTACTGGATGAGGATGTCTGGGAATTCATATGGATGAAATTCCATTCCA
CCACAGCAGTTTCTGAGAAGAAAATATTATTGGAAGCCTTAACTTGCAGTGATGACAGGAATTTATTAAACAGGCTTCTAAATCTGTCAC
TGAATTCTGAGGTGGTGCTGGATCAAGATGCAATTGATGTCATAATCCATGTAGCTCGAAATCCACATGGTCGAGACCTTGCCTGGAAGT
TTTTCAGGGATAAATGGAAGATATTAAATACCAGGTATGGAGAAGCATTGTTTATGAATTCCAAACTCATCAGTGGTGTCACAGAATTTC
TTAATACTGAAGGTGAACTCAAAGAGCTCAAGAACTTCATGAAAAACTATGATGGGGTAGCTGCTGCTTCTTTCTCACGAGCTGTGGAAA
CTGTCGAAGCCAATGTGCGCTGGAAAATGCTTTACCAAGACGAGCTTTTCCAATGGTTAGGAAAAGCTCTAAGACACTAATATATGTATC
TTATAAACAAACAATTCAACTCAGAAGTTTATGAGAAGACACGCTTTTTGTGGAATGAGGAAAATGTACTACCTAGAAAATGGCCAGATT
TTCAGTGTTAACGTGTGGGAGGAATTTTTTTTTTAGTTTTTATTTTTTGGTTTTGGGGGATATTTTTTATTTGTTTCATTCATTCTGTTC
TGTTTCTCTACTGGGTGTTCCTCTCTAAAGAAACTCTTGCAAGTGAAACTAGCCATGATTGCTTCAGCTGTACATTCCTTGCTGTACAGG
ACCAAATATGATAGTGATGCATGTTGATGTTACAGTCAATTTGGAAAAACATATTCAGAATATCTGTGCATGGATATATTGTCCTGCCTG
TGTTCCAGCATGCTTATTTCAAACGTCCAGTGTTGTGTGTGAATATGTGTTACACCTAGGATGGGCATTATGCAAAAGCACAAAGATTAT
ATATGACAATCAGTATTGCAATGAAAGAAAAACTAAAAACAGAAATGATATTCTCAATTTTGGGCAATGTGAGAGGTAAAATAGCCCTTG
ACATGATGAACATCACTTATTTCAGCACTTGGATTGTCTGGCAATGATTACTGTGTTGCTAACTCATTTTCTTTGAGTTAAAGCTGTGTA
TACATTTTAAAAGGCATATAGATAGTGTATGCATATGTATATGTACATAGGGAAGCCCCATATGTATATAGTATGTTGTACACTGCACAT
GTACAAAGAATGTCTTCAGATCAAAGAAAATTTATCTCTTTTTATAAACTTAAGGACAGTTGCAAAAGGCTTCAAGGAATTTATCTCAAC
ATTATTCTTTCTATGTCCTAACTAAATTTCTCAACTGTTATGAATTTTTCATCTACTTCTTGAACAGTGGTCTATTCTGCTACATGAAGA
TGAATACAAACAAAATTTTTGTATAAACTACTATTCCAGTTCTCCTGTGTCAGTCTTGCCTATAGATTTTGCCATCGTTTTCTGTCAAAG
TTCCTTTTGCATGAAACAATTATGCAAACTTATAATTATTAGTGCTGAAAAAGAGTTTATTTTCCATCTTGTTTGTTTTCCTACCTTATG
CTGAGTAGTCCAGAGAGTTAAAAAAATTCTCTGCATGTTGGTCTTTTAAGTCTGTTTTGCTCTAATCCTCCATTAAGCGAGCATACCTCA
AGTGGGTCTATTAGCATTTAATGACCTTTTGTGCCAGTTGTGCCATCCCTTAAGATGAAAAGTTCCTTTTCTTGTGTTAATGTACAAAGC
TTTTCTTTTGGCACTGACAACTGTGTTCTACCTGGGAATTTTGAATAGCCATTTTCATGGCTGTGTGTTGTGTAACACAAATGTTTTTAA
ATGGTATTCTCACCCAGTAGGCCAGCTCTCCAAACGTTGCTTAGATGCTTCAAAATTAGCATATTTTAAGTTTACCAGTATAAAATACCA
ATGCAACTACTCTACATAGCCAAATGTTTGTAAATCACGTCTTATTTTCCTGAGGTTTTTCACTCCACCAAATCTTACAAATCATTGAAA
GAAATATATTCTAACAGTACGCACTGAATAGTGAAAATAATTAGACATTTTAAGAACCAGAGCCATAGAATTATTTTAAATTAGTAGAAA
AGAGGAGCTATTTCCGAATCTATAGAATAAAGTACCACCTAAAACTGAATTTTATCATATAAGCAAGTAATACCTATTAGTCATACCTAA
ATTTTTCAGCACTTCATTCAATTAAAATACATGAATTTTAAATATTTTACATGATGTGAATAGGCATGATAATACTTTTAGTATAAAATC
TAAACTTTTTCCATTTATCAGAAATGATAAAATCCAGTTACCACATATCACGTTTATAAAATCCTTAATTAAATGAGTAACTTCTAAAAT
ATAACAATACTAAATATCACACTGCGATGGAGGTCCCAAATATGTGGTCTATCACCACTGAATTCATGTAATAGATAAGAAAAAAATTAG
AGGTGGATGTCTTGTTTTGTGTCATGAATTACTAAAATCTCTTAGTAGTTGTGGTATATTTTTGAGTAAAATTACCATTTCCAGATTTGA
GTTTGAAGGGCTTTTATAGTTGTATTTTCCTCCTCACTGTTAATAATCATAATCCTTTTTCAGTATTTTAGTGGCCTTGAACAACTGGTT
TATCTACAATCTCAAATCCTAAGTGTATAATTATGTGCAATGTTCAATACCTCATATAATACTTGCTCAACAGTATAGTGGTACCAATGG
CATTAAGATGGTGTTTTTGTTCTACATATTTTTCAATAATTTATTCTTTCTAATGTTGAAATTATATCAGGCTTTACCGGTTTTTTTAGT
TGTTTAAATAAGTAATATTTTCAAAAGAATAAAATAACCAATGATATCTCTTGGAATAATCTGTAAAACGTAGTTATAAAATTCTATTTT

>15044_15044_2_CDH1-TRHDE_CDH1_chr16_68835796_ENST00000261769_TRHDE_chr12_72771775_ENST00000261180_length(amino acids)=852AA_BP=179
MAAATHPLSVASELQSTCELAEVSSDSSPLQPGPTRPHPAPALARRPRPAMGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFT
VPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQV
RLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEI
CHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAA
LIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYD
ISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVL
SVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGS
LVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEAL
TCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFM

--------------------------------------------------------------
>15044_15044_3_CDH1-TRHDE_CDH1_chr16_68835796_ENST00000422392_TRHDE_chr12_72771774_ENST00000261180_length(transcript)=4920nt_BP=451nt
GCTCCAGCCCGGCCCGACCCGACCGCACCCGGCGCCTGCCCTCGCTCGGCGTCCCCGGCCAGCCATGGGCCCTTGGAGCCGCAGCCTCTC
GGCGCTGCTGCTGCTGCTGCAGGTCTCCTCTTGGCTCTGCCAGGAGCCGGAGCCCTGCCACCCTGGCTTTGACGCCGAGAGCTACACGTT
CACGGTGCCCCGGCGCCACCTGGAGAGAGGCCGCGTCCTGGGCAGAGTGAATTTTGAAGATTGCACCGGTCGACAAAGGACAGCCTATTT
TTCCCTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGATTACAGTCAAAAGGCCTCTACGGTTTCATAACCCACAGATCCATTTCTT
GGTCTACGCCTGGGACTCCACCTACAGAAAGTTTTCCACCAAAGTCACGCTGAATACAGTGGGGCACCACCACCGCCCCCCGCCCCATCA
GGTACGATTATATGCAAGACCTGATGCTATCAGAAGAGGATCCGGGGACTATGCTCTCCATATAACAAAGAGATTAATAGAATTTTATGA
AGACTACTTTAAAGTGCCCTATTCCTTGCCAAAACTAGATCTTTTAGCTGTGCCTAAGCATCCGTATGCTGCTATGGAGAACTGGGGACT
AAGTATTTTTGTGGAACAAAGAATACTGCTGGATCCCAGTGTTTCATCTATTTCTTATTTGCTGGATGTCACCATGGTCATTGTTCATGA
GATATGTCACCAGTGGTTTGGTGACCTTGTGACGCCTGTGTGGTGGGAAGACGTGTGGCTGAAGGAAGGGTTTGCTCACTACTTTGAATT
TGTTGGTACAGACTACCTCTATCCTGGCTGGAACATGGAAAAGCAGAGGTTTCTGACCGATGTTCTGCATGAAGTGATGCTGCTGGACGG
TTTGGCCAGTTCCCATCCAGTATCACAGGAAGTGCTGCAGGCAACAGATATTGACAGGGTGTTTGACTGGATCGCATATAAAAAGGGTGC
TGCTTTAATAAGAATGCTGGCTAATTTTATGGGCCATTCAGTTTTCCAGAGGGGTTTGCAAGATTATTTAACCATTCATAAGTATGGTAA
TGCAGCCAGAAATGATCTCTGGAATACATTATCGGAGGCTTTAAAAAGAAATGGGAAATATGTAAATATACAAGAAGTAATGGATCAGTG
GACACTCCAGATGGGTTATCCTGTTATCACCATCTTGGGAAACACAACAGCAGAAAATAGAATAATAATTACCCAACAGCATTTTATCTA
TGATATCAGTGCTAAAACTAAAGCACTTAAACTTCAGAATAACAGTTACCTGTGGCAGATTCCATTAACTATTGTGGTAGGAAATAGAAG
CCATGTGTCTTCAGAAGCAATTATTTGGGTGTCTAACAAATCAGAGCACCACAGAATAACTTATTTGGACAAAGGAAGCTGGCTGCTGGG
GAACATCAATCAAACTGGCTATTTTAGAGTCAACTATGACCTAAGGAACTGGAGATTATTAATTGATCAATTAATCCGGAATCATGAGGT
TCTTTCTGTCAGTAACCGAGCGGGCTTGATCGATGATGCCTTCAGCCTAGCCAGGGCTGGCTATTTGCCTCAGAATATTCCTCTGGAGAT
TATCAGATACCTGTCTGAGGAGAAGGATTTTCTTCCTTGGCATGCTGCCAGCCGAGCTCTTTATCCTCTAGATAAATTACTGGACCGCAT
GGAAAACTACAACATTTTCAATGAATATATTTTAAAGCAAGTTGCAACAACATATATCAAGCTTGGGTGGCCGAAAAATAATTTTAATGG
ATCTCTTGTTCAAGCATCCTACCAACATGAAGAACTACGTAGAGAAGTTATAATGCTGGCCTGCAGTTTTGGCAACAAGCACTGTCACCA
ACAGGCATCAACACTTATTTCAGATTGGATTTCCAGCAACAGGAACAGAATACCACTAAATGTTAGAGACATCGTATACTGTACAGGAGT
GTCACTACTGGATGAGGATGTCTGGGAATTCATATGGATGAAATTCCATTCCACCACAGCAGTTTCTGAGAAGAAAATATTATTGGAAGC
CTTAACTTGCAGTGATGACAGGAATTTATTAAACAGGCTTCTAAATCTGTCACTGAATTCTGAGGTGGTGCTGGATCAAGATGCAATTGA
TGTCATAATCCATGTAGCTCGAAATCCACATGGTCGAGACCTTGCCTGGAAGTTTTTCAGGGATAAATGGAAGATATTAAATACCAGGTA
TGGAGAAGCATTGTTTATGAATTCCAAACTCATCAGTGGTGTCACAGAATTTCTTAATACTGAAGGTGAACTCAAAGAGCTCAAGAACTT
CATGAAAAACTATGATGGGGTAGCTGCTGCTTCTTTCTCACGAGCTGTGGAAACTGTCGAAGCCAATGTGCGCTGGAAAATGCTTTACCA
AGACGAGCTTTTCCAATGGTTAGGAAAAGCTCTAAGACACTAATATATGTATCTTATAAACAAACAATTCAACTCAGAAGTTTATGAGAA
GACACGCTTTTTGTGGAATGAGGAAAATGTACTACCTAGAAAATGGCCAGATTTTCAGTGTTAACGTGTGGGAGGAATTTTTTTTTTAGT
TTTTATTTTTTGGTTTTGGGGGATATTTTTTATTTGTTTCATTCATTCTGTTCTGTTTCTCTACTGGGTGTTCCTCTCTAAAGAAACTCT
TGCAAGTGAAACTAGCCATGATTGCTTCAGCTGTACATTCCTTGCTGTACAGGACCAAATATGATAGTGATGCATGTTGATGTTACAGTC
AATTTGGAAAAACATATTCAGAATATCTGTGCATGGATATATTGTCCTGCCTGTGTTCCAGCATGCTTATTTCAAACGTCCAGTGTTGTG
TGTGAATATGTGTTACACCTAGGATGGGCATTATGCAAAAGCACAAAGATTATATATGACAATCAGTATTGCAATGAAAGAAAAACTAAA
AACAGAAATGATATTCTCAATTTTGGGCAATGTGAGAGGTAAAATAGCCCTTGACATGATGAACATCACTTATTTCAGCACTTGGATTGT
CTGGCAATGATTACTGTGTTGCTAACTCATTTTCTTTGAGTTAAAGCTGTGTATACATTTTAAAAGGCATATAGATAGTGTATGCATATG
TATATGTACATAGGGAAGCCCCATATGTATATAGTATGTTGTACACTGCACATGTACAAAGAATGTCTTCAGATCAAAGAAAATTTATCT
CTTTTTATAAACTTAAGGACAGTTGCAAAAGGCTTCAAGGAATTTATCTCAACATTATTCTTTCTATGTCCTAACTAAATTTCTCAACTG
TTATGAATTTTTCATCTACTTCTTGAACAGTGGTCTATTCTGCTACATGAAGATGAATACAAACAAAATTTTTGTATAAACTACTATTCC
AGTTCTCCTGTGTCAGTCTTGCCTATAGATTTTGCCATCGTTTTCTGTCAAAGTTCCTTTTGCATGAAACAATTATGCAAACTTATAATT
ATTAGTGCTGAAAAAGAGTTTATTTTCCATCTTGTTTGTTTTCCTACCTTATGCTGAGTAGTCCAGAGAGTTAAAAAAATTCTCTGCATG
TTGGTCTTTTAAGTCTGTTTTGCTCTAATCCTCCATTAAGCGAGCATACCTCAAGTGGGTCTATTAGCATTTAATGACCTTTTGTGCCAG
TTGTGCCATCCCTTAAGATGAAAAGTTCCTTTTCTTGTGTTAATGTACAAAGCTTTTCTTTTGGCACTGACAACTGTGTTCTACCTGGGA
ATTTTGAATAGCCATTTTCATGGCTGTGTGTTGTGTAACACAAATGTTTTTAAATGGTATTCTCACCCAGTAGGCCAGCTCTCCAAACGT
TGCTTAGATGCTTCAAAATTAGCATATTTTAAGTTTACCAGTATAAAATACCAATGCAACTACTCTACATAGCCAAATGTTTGTAAATCA
CGTCTTATTTTCCTGAGGTTTTTCACTCCACCAAATCTTACAAATCATTGAAAGAAATATATTCTAACAGTACGCACTGAATAGTGAAAA
TAATTAGACATTTTAAGAACCAGAGCCATAGAATTATTTTAAATTAGTAGAAAAGAGGAGCTATTTCCGAATCTATAGAATAAAGTACCA
CCTAAAACTGAATTTTATCATATAAGCAAGTAATACCTATTAGTCATACCTAAATTTTTCAGCACTTCATTCAATTAAAATACATGAATT
TTAAATATTTTACATGATGTGAATAGGCATGATAATACTTTTAGTATAAAATCTAAACTTTTTCCATTTATCAGAAATGATAAAATCCAG
TTACCACATATCACGTTTATAAAATCCTTAATTAAATGAGTAACTTCTAAAATATAACAATACTAAATATCACACTGCGATGGAGGTCCC
AAATATGTGGTCTATCACCACTGAATTCATGTAATAGATAAGAAAAAAATTAGAGGTGGATGTCTTGTTTTGTGTCATGAATTACTAAAA
TCTCTTAGTAGTTGTGGTATATTTTTGAGTAAAATTACCATTTCCAGATTTGAGTTTGAAGGGCTTTTATAGTTGTATTTTCCTCCTCAC
TGTTAATAATCATAATCCTTTTTCAGTATTTTAGTGGCCTTGAACAACTGGTTTATCTACAATCTCAAATCCTAAGTGTATAATTATGTG
CAATGTTCAATACCTCATATAATACTTGCTCAACAGTATAGTGGTACCAATGGCATTAAGATGGTGTTTTTGTTCTACATATTTTTCAAT
AATTTATTCTTTCTAATGTTGAAATTATATCAGGCTTTACCGGTTTTTTTAGTTGTTTAAATAAGTAATATTTTCAAAAGAATAAAATAA

>15044_15044_3_CDH1-TRHDE_CDH1_chr16_68835796_ENST00000422392_TRHDE_chr12_72771774_ENST00000261180_length(amino acids)=802AA_BP=129
MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLR
FHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHP
YAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDV
LHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYV
NIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITY
LDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALY
PLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNV
RDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRD

--------------------------------------------------------------
>15044_15044_4_CDH1-TRHDE_CDH1_chr16_68835796_ENST00000422392_TRHDE_chr12_72771775_ENST00000261180_length(transcript)=4920nt_BP=451nt
GCTCCAGCCCGGCCCGACCCGACCGCACCCGGCGCCTGCCCTCGCTCGGCGTCCCCGGCCAGCCATGGGCCCTTGGAGCCGCAGCCTCTC
GGCGCTGCTGCTGCTGCTGCAGGTCTCCTCTTGGCTCTGCCAGGAGCCGGAGCCCTGCCACCCTGGCTTTGACGCCGAGAGCTACACGTT
CACGGTGCCCCGGCGCCACCTGGAGAGAGGCCGCGTCCTGGGCAGAGTGAATTTTGAAGATTGCACCGGTCGACAAAGGACAGCCTATTT
TTCCCTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGATTACAGTCAAAAGGCCTCTACGGTTTCATAACCCACAGATCCATTTCTT
GGTCTACGCCTGGGACTCCACCTACAGAAAGTTTTCCACCAAAGTCACGCTGAATACAGTGGGGCACCACCACCGCCCCCCGCCCCATCA
GGTACGATTATATGCAAGACCTGATGCTATCAGAAGAGGATCCGGGGACTATGCTCTCCATATAACAAAGAGATTAATAGAATTTTATGA
AGACTACTTTAAAGTGCCCTATTCCTTGCCAAAACTAGATCTTTTAGCTGTGCCTAAGCATCCGTATGCTGCTATGGAGAACTGGGGACT
AAGTATTTTTGTGGAACAAAGAATACTGCTGGATCCCAGTGTTTCATCTATTTCTTATTTGCTGGATGTCACCATGGTCATTGTTCATGA
GATATGTCACCAGTGGTTTGGTGACCTTGTGACGCCTGTGTGGTGGGAAGACGTGTGGCTGAAGGAAGGGTTTGCTCACTACTTTGAATT
TGTTGGTACAGACTACCTCTATCCTGGCTGGAACATGGAAAAGCAGAGGTTTCTGACCGATGTTCTGCATGAAGTGATGCTGCTGGACGG
TTTGGCCAGTTCCCATCCAGTATCACAGGAAGTGCTGCAGGCAACAGATATTGACAGGGTGTTTGACTGGATCGCATATAAAAAGGGTGC
TGCTTTAATAAGAATGCTGGCTAATTTTATGGGCCATTCAGTTTTCCAGAGGGGTTTGCAAGATTATTTAACCATTCATAAGTATGGTAA
TGCAGCCAGAAATGATCTCTGGAATACATTATCGGAGGCTTTAAAAAGAAATGGGAAATATGTAAATATACAAGAAGTAATGGATCAGTG
GACACTCCAGATGGGTTATCCTGTTATCACCATCTTGGGAAACACAACAGCAGAAAATAGAATAATAATTACCCAACAGCATTTTATCTA
TGATATCAGTGCTAAAACTAAAGCACTTAAACTTCAGAATAACAGTTACCTGTGGCAGATTCCATTAACTATTGTGGTAGGAAATAGAAG
CCATGTGTCTTCAGAAGCAATTATTTGGGTGTCTAACAAATCAGAGCACCACAGAATAACTTATTTGGACAAAGGAAGCTGGCTGCTGGG
GAACATCAATCAAACTGGCTATTTTAGAGTCAACTATGACCTAAGGAACTGGAGATTATTAATTGATCAATTAATCCGGAATCATGAGGT
TCTTTCTGTCAGTAACCGAGCGGGCTTGATCGATGATGCCTTCAGCCTAGCCAGGGCTGGCTATTTGCCTCAGAATATTCCTCTGGAGAT
TATCAGATACCTGTCTGAGGAGAAGGATTTTCTTCCTTGGCATGCTGCCAGCCGAGCTCTTTATCCTCTAGATAAATTACTGGACCGCAT
GGAAAACTACAACATTTTCAATGAATATATTTTAAAGCAAGTTGCAACAACATATATCAAGCTTGGGTGGCCGAAAAATAATTTTAATGG
ATCTCTTGTTCAAGCATCCTACCAACATGAAGAACTACGTAGAGAAGTTATAATGCTGGCCTGCAGTTTTGGCAACAAGCACTGTCACCA
ACAGGCATCAACACTTATTTCAGATTGGATTTCCAGCAACAGGAACAGAATACCACTAAATGTTAGAGACATCGTATACTGTACAGGAGT
GTCACTACTGGATGAGGATGTCTGGGAATTCATATGGATGAAATTCCATTCCACCACAGCAGTTTCTGAGAAGAAAATATTATTGGAAGC
CTTAACTTGCAGTGATGACAGGAATTTATTAAACAGGCTTCTAAATCTGTCACTGAATTCTGAGGTGGTGCTGGATCAAGATGCAATTGA
TGTCATAATCCATGTAGCTCGAAATCCACATGGTCGAGACCTTGCCTGGAAGTTTTTCAGGGATAAATGGAAGATATTAAATACCAGGTA
TGGAGAAGCATTGTTTATGAATTCCAAACTCATCAGTGGTGTCACAGAATTTCTTAATACTGAAGGTGAACTCAAAGAGCTCAAGAACTT
CATGAAAAACTATGATGGGGTAGCTGCTGCTTCTTTCTCACGAGCTGTGGAAACTGTCGAAGCCAATGTGCGCTGGAAAATGCTTTACCA
AGACGAGCTTTTCCAATGGTTAGGAAAAGCTCTAAGACACTAATATATGTATCTTATAAACAAACAATTCAACTCAGAAGTTTATGAGAA
GACACGCTTTTTGTGGAATGAGGAAAATGTACTACCTAGAAAATGGCCAGATTTTCAGTGTTAACGTGTGGGAGGAATTTTTTTTTTAGT
TTTTATTTTTTGGTTTTGGGGGATATTTTTTATTTGTTTCATTCATTCTGTTCTGTTTCTCTACTGGGTGTTCCTCTCTAAAGAAACTCT
TGCAAGTGAAACTAGCCATGATTGCTTCAGCTGTACATTCCTTGCTGTACAGGACCAAATATGATAGTGATGCATGTTGATGTTACAGTC
AATTTGGAAAAACATATTCAGAATATCTGTGCATGGATATATTGTCCTGCCTGTGTTCCAGCATGCTTATTTCAAACGTCCAGTGTTGTG
TGTGAATATGTGTTACACCTAGGATGGGCATTATGCAAAAGCACAAAGATTATATATGACAATCAGTATTGCAATGAAAGAAAAACTAAA
AACAGAAATGATATTCTCAATTTTGGGCAATGTGAGAGGTAAAATAGCCCTTGACATGATGAACATCACTTATTTCAGCACTTGGATTGT
CTGGCAATGATTACTGTGTTGCTAACTCATTTTCTTTGAGTTAAAGCTGTGTATACATTTTAAAAGGCATATAGATAGTGTATGCATATG
TATATGTACATAGGGAAGCCCCATATGTATATAGTATGTTGTACACTGCACATGTACAAAGAATGTCTTCAGATCAAAGAAAATTTATCT
CTTTTTATAAACTTAAGGACAGTTGCAAAAGGCTTCAAGGAATTTATCTCAACATTATTCTTTCTATGTCCTAACTAAATTTCTCAACTG
TTATGAATTTTTCATCTACTTCTTGAACAGTGGTCTATTCTGCTACATGAAGATGAATACAAACAAAATTTTTGTATAAACTACTATTCC
AGTTCTCCTGTGTCAGTCTTGCCTATAGATTTTGCCATCGTTTTCTGTCAAAGTTCCTTTTGCATGAAACAATTATGCAAACTTATAATT
ATTAGTGCTGAAAAAGAGTTTATTTTCCATCTTGTTTGTTTTCCTACCTTATGCTGAGTAGTCCAGAGAGTTAAAAAAATTCTCTGCATG
TTGGTCTTTTAAGTCTGTTTTGCTCTAATCCTCCATTAAGCGAGCATACCTCAAGTGGGTCTATTAGCATTTAATGACCTTTTGTGCCAG
TTGTGCCATCCCTTAAGATGAAAAGTTCCTTTTCTTGTGTTAATGTACAAAGCTTTTCTTTTGGCACTGACAACTGTGTTCTACCTGGGA
ATTTTGAATAGCCATTTTCATGGCTGTGTGTTGTGTAACACAAATGTTTTTAAATGGTATTCTCACCCAGTAGGCCAGCTCTCCAAACGT
TGCTTAGATGCTTCAAAATTAGCATATTTTAAGTTTACCAGTATAAAATACCAATGCAACTACTCTACATAGCCAAATGTTTGTAAATCA
CGTCTTATTTTCCTGAGGTTTTTCACTCCACCAAATCTTACAAATCATTGAAAGAAATATATTCTAACAGTACGCACTGAATAGTGAAAA
TAATTAGACATTTTAAGAACCAGAGCCATAGAATTATTTTAAATTAGTAGAAAAGAGGAGCTATTTCCGAATCTATAGAATAAAGTACCA
CCTAAAACTGAATTTTATCATATAAGCAAGTAATACCTATTAGTCATACCTAAATTTTTCAGCACTTCATTCAATTAAAATACATGAATT
TTAAATATTTTACATGATGTGAATAGGCATGATAATACTTTTAGTATAAAATCTAAACTTTTTCCATTTATCAGAAATGATAAAATCCAG
TTACCACATATCACGTTTATAAAATCCTTAATTAAATGAGTAACTTCTAAAATATAACAATACTAAATATCACACTGCGATGGAGGTCCC
AAATATGTGGTCTATCACCACTGAATTCATGTAATAGATAAGAAAAAAATTAGAGGTGGATGTCTTGTTTTGTGTCATGAATTACTAAAA
TCTCTTAGTAGTTGTGGTATATTTTTGAGTAAAATTACCATTTCCAGATTTGAGTTTGAAGGGCTTTTATAGTTGTATTTTCCTCCTCAC
TGTTAATAATCATAATCCTTTTTCAGTATTTTAGTGGCCTTGAACAACTGGTTTATCTACAATCTCAAATCCTAAGTGTATAATTATGTG
CAATGTTCAATACCTCATATAATACTTGCTCAACAGTATAGTGGTACCAATGGCATTAAGATGGTGTTTTTGTTCTACATATTTTTCAAT
AATTTATTCTTTCTAATGTTGAAATTATATCAGGCTTTACCGGTTTTTTTAGTTGTTTAAATAAGTAATATTTTCAAAAGAATAAAATAA

>15044_15044_4_CDH1-TRHDE_CDH1_chr16_68835796_ENST00000422392_TRHDE_chr12_72771775_ENST00000261180_length(amino acids)=802AA_BP=129
MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLR
FHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHP
YAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDV
LHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYV
NIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITY
LDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALY
PLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNV
RDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRD

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Fusion Gene PPI Analysis for CDH1-TRHDE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDH1-TRHDE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDH1-TRHDE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDH1C1708349Hereditary Diffuse Gastric Cancer15CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneCDH1C0346153Breast Cancer, Familial12CLINGEN
HgeneCDH1C0009405Hereditary Nonpolyposis Colorectal Neoplasms6CLINGEN
HgeneCDH1C0024623Malignant neoplasm of stomach6CGI;CTD_human;UNIPROT
HgeneCDH1C0038356Stomach Neoplasms6CGI;CTD_human
HgeneCDH1C1112155Hereditary non-polyposis colorectal cancer syndrome6CLINGEN
HgeneCDH1C1333990Hereditary Nonpolyposis Colorectal Cancer6CLINGEN
HgeneCDH1C1333991Hereditary Non-Polyposis Colon Cancer Type 26CLINGEN
HgeneCDH1C2936783Colorectal cancer, hereditary nonpolyposis, type 16CLINGEN
HgeneCDH1C0006142Malignant neoplasm of breast4CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneCDH1C0033578Prostatic Neoplasms4CTD_human
HgeneCDH1C0376358Malignant neoplasm of prostate4CTD_human;GENOMICS_ENGLAND
HgeneCDH1C0678222Breast Carcinoma4CTD_human
HgeneCDH1C1257931Mammary Neoplasms, Human4CTD_human
HgeneCDH1C1458155Mammary Neoplasms4CTD_human
HgeneCDH1C4704874Mammary Carcinoma, Human4CTD_human
HgeneCDH1C0007097Carcinoma3CTD_human
HgeneCDH1C0205696Anaplastic carcinoma3CTD_human
HgeneCDH1C0205697Carcinoma, Spindle-Cell3CTD_human
HgeneCDH1C0205698Undifferentiated carcinoma3CTD_human
HgeneCDH1C0205699Carcinomatosis3CTD_human
HgeneCDH1C0005684Malignant neoplasm of urinary bladder2CTD_human
HgeneCDH1C0005695Bladder Neoplasm2CTD_human
HgeneCDH1C0009402Colorectal Carcinoma2CTD_human
HgeneCDH1C0009404Colorectal Neoplasms2CTD_human
HgeneCDH1C0019207Hepatoma, Morris2CTD_human
HgeneCDH1C0019208Hepatoma, Novikoff2CTD_human
HgeneCDH1C0021367Mammary Ductal Carcinoma2CTD_human
HgeneCDH1C0023904Liver Neoplasms, Experimental2CTD_human
HgeneCDH1C0027626Neoplasm Invasiveness2CTD_human
HgeneCDH1C0027627Neoplasm Metastasis2CTD_human
HgeneCDH1C0086404Experimental Hepatoma2CTD_human
HgeneCDH1C0206692Carcinoma, Lobular2CGI;CTD_human;UNIPROT
HgeneCDH1C1134719Invasive Ductal Breast Carcinoma2CTD_human
HgeneCDH1C2931456Prostate cancer, familial2CTD_human
HgeneCDH1C4551988BLEPHAROCHEILODONTIC SYNDROME 12GENOMICS_ENGLAND;UNIPROT
HgeneCDH1C4722327PROSTATE CANCER, HEREDITARY, 12CTD_human
HgeneCDH1C0007137Squamous cell carcinoma1CTD_human
HgeneCDH1C0007621Neoplastic Cell Transformation1CTD_human
HgeneCDH1C0009324Ulcerative Colitis1CTD_human
HgeneCDH1C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneCDH1C0014170Endometrial Neoplasms1CTD_human
HgeneCDH1C0014476Eperythrozoonosis1CTD_human
HgeneCDH1C0024667Animal Mammary Neoplasms1CTD_human
HgeneCDH1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneCDH1C0025500Mesothelioma1CTD_human
HgeneCDH1C0026936Mycoplasma Infections1CTD_human
HgeneCDH1C0027645Neoplasm Seeding1CTD_human
HgeneCDH1C0027659Neoplasms, Experimental1CTD_human
HgeneCDH1C0027746Nerve Degeneration1CTD_human
HgeneCDH1C0030297Pancreatic Neoplasm1CTD_human
HgeneCDH1C0032927Precancerous Conditions1CTD_human
HgeneCDH1C0036095Salivary Gland Neoplasms1CTD_human
HgeneCDH1C0079487Helicobacter Infections1CTD_human
HgeneCDH1C0158646Cleft palate with cleft lip1ORPHANET
HgeneCDH1C0220636Malignant neoplasm of salivary gland1CTD_human
HgeneCDH1C0235874Disease Exacerbation1CTD_human
HgeneCDH1C0282313Condition, Preneoplastic1CTD_human
HgeneCDH1C0282612Prostatic Intraepithelial Neoplasias1CTD_human
HgeneCDH1C0346647Malignant neoplasm of pancreas1CTD_human
HgeneCDH1C0476089Endometrial Carcinoma1CTD_human;GENOMICS_ENGLAND
HgeneCDH1C0919267ovarian neoplasm1CTD_human
HgeneCDH1C1140680Malignant neoplasm of ovary1CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneCDH1C1176475Ductal Carcinoma1CTD_human
HgeneCDH1C1257925Mammary Carcinoma, Animal1CTD_human
HgeneCDH1C1861536Blepharo-cheilo-dontic syndrome1ORPHANET