PartnerGene Hgene Hbp Hstrand Tgene Tbp Tstrand ENST UniproAcc BPexon(0-based) #exon domainLoci BPatProtein totalCDSlength domainType UniprotNote Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 1_21 303.3333333333333 496.0 retained Signal peptide Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3458201;Dbxref=PMID:3458201 Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 22_495 303.3333333333333 496.0 not_retained Chain ID=PRO_0000014502;Note=Alpha-1B-glycoprotein Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 22_113 303.3333333333333 496.0 retained Domain Note=Ig-like V-type 1 Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 114_206 303.3333333333333 496.0 retained Domain Note=Ig-like V-type 2 Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 207_299 303.3333333333333 496.0 retained Domain Note=Ig-like V-type 3 Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 300_397 303.3333333333333 496.0 not_retained Domain Note=Ig-like V-type 4 Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 398_495 303.3333333333333 496.0 not_retained Domain Note=Ig-like V-type 5 Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 44_44 303.3333333333333 496.0 retained Glycosylation Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19838169,ECO:0000269|PubMed:3458201;Dbxref=PMID:14760718,PMID:16335952,PMID:19838169,PMID:3458201 Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 179_179 303.3333333333333 496.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:3458201;Dbxref=PMID:14760718,PMID:16335952,PMID:3458201 Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 363_363 303.3333333333333 496.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:3458201;Dbxref=PMID:16335952,PMID:3458201 Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 371_371 303.3333333333333 496.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:3458201;Dbxref=PMID:16335952,PMID:3458201 Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 49_93 303.3333333333333 496.0 retained Disulfide bond Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:3458201;Dbxref=PMID:3458201 Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 139_182 303.3333333333333 496.0 retained Disulfide bond Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:3458201;Dbxref=PMID:3458201 Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 232_279 303.3333333333333 496.0 retained Disulfide bond Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:3458201;Dbxref=PMID:3458201 Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 325_374 303.3333333333333 496.0 not_retained Disulfide bond Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:3458201;Dbxref=PMID:3458201 Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 423_470 303.3333333333333 496.0 not_retained Disulfide bond Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:3458201;Dbxref=PMID:3458201 Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 1_122 303.3333333333333 496.0 retained Alternative sequence ID=VSP_040323;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 52_52 303.3333333333333 496.0 retained Natural variant ID=VAR_018369;Note=H->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:3458201,ECO:0000269|Ref.2;Dbxref=dbSNP:rs893184,PMID:14702039,PMID:3458201 Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 395_395 303.3333333333333 496.0 not_retained Natural variant ID=VAR_018370;Note=H->R;Dbxref=dbSNP:rs2241788 Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 105_105 303.3333333333333 496.0 retained Sequence conflict Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 127_127 303.3333333333333 496.0 retained Sequence conflict Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 146_146 303.3333333333333 496.0 retained Sequence conflict Note=V->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 304_304 303.3333333333333 496.0 retained Sequence conflict Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 413_413 303.3333333333333 496.0 not_retained Sequence conflict Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A1BG chr19:58862757 - ITIH4 chr3:52852299 ENST00000263100 P04217 5 8 446_447 303.3333333333333 496.0 not_retained Sequence conflict Note=VR->IP;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 1_21 23.333333333333332 496.0 retained Signal peptide Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3458201;Dbxref=PMID:3458201 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 22_495 23.333333333333332 496.0 not_retained Chain ID=PRO_0000014502;Note=Alpha-1B-glycoprotein Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 22_113 23.333333333333332 496.0 not_retained Domain Note=Ig-like V-type 1 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 114_206 23.333333333333332 496.0 not_retained Domain Note=Ig-like V-type 2 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 207_299 23.333333333333332 496.0 not_retained Domain Note=Ig-like V-type 3 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 300_397 23.333333333333332 496.0 not_retained Domain Note=Ig-like V-type 4 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 398_495 23.333333333333332 496.0 not_retained Domain Note=Ig-like V-type 5 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 44_44 23.333333333333332 496.0 not_retained Glycosylation Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19838169,ECO:0000269|PubMed:3458201;Dbxref=PMID:14760718,PMID:16335952,PMID:19838169,PMID:3458201 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 179_179 23.333333333333332 496.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:3458201;Dbxref=PMID:14760718,PMID:16335952,PMID:3458201 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 363_363 23.333333333333332 496.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:3458201;Dbxref=PMID:16335952,PMID:3458201 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 371_371 23.333333333333332 496.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:3458201;Dbxref=PMID:16335952,PMID:3458201 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 49_93 23.333333333333332 496.0 not_retained Disulfide bond Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:3458201;Dbxref=PMID:3458201 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 139_182 23.333333333333332 496.0 not_retained Disulfide bond Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:3458201;Dbxref=PMID:3458201 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 232_279 23.333333333333332 496.0 not_retained Disulfide bond Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:3458201;Dbxref=PMID:3458201 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 325_374 23.333333333333332 496.0 not_retained Disulfide bond Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:3458201;Dbxref=PMID:3458201 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 423_470 23.333333333333332 496.0 not_retained Disulfide bond Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:3458201;Dbxref=PMID:3458201 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 1_122 23.333333333333332 496.0 not_retained Alternative sequence ID=VSP_040323;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 52_52 23.333333333333332 496.0 not_retained Natural variant ID=VAR_018369;Note=H->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:3458201,ECO:0000269|Ref.2;Dbxref=dbSNP:rs893184,PMID:14702039,PMID:3458201 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 395_395 23.333333333333332 496.0 not_retained Natural variant ID=VAR_018370;Note=H->R;Dbxref=dbSNP:rs2241788 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 105_105 23.333333333333332 496.0 not_retained Sequence conflict Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 127_127 23.333333333333332 496.0 not_retained Sequence conflict Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 146_146 23.333333333333332 496.0 not_retained Sequence conflict Note=V->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 304_304 23.333333333333332 496.0 not_retained Sequence conflict Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 413_413 23.333333333333332 496.0 not_retained Sequence conflict Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A1BG chr19:58864658 - FGA chr4:155508809 ENST00000263100 P04217 2 8 446_447 23.333333333333332 496.0 not_retained Sequence conflict Note=VR->IP;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 1_23 1512.0 1475.0 retained Signal peptide Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 24_1474 1512.0 1475.0 retained Chain ID=PRO_0000000055;Note=Alpha-2-macroglobulin;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 690_728 1512.0 1475.0 retained Region Note=Bait region Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 704_709 1512.0 1475.0 retained Region Note=Inhibitory Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 719_723 1512.0 1475.0 retained Region Note=Inhibitory Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 730_735 1512.0 1475.0 retained Region Note=Inhibitory Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 55_55 1512.0 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19139490;Dbxref=PMID:16335952,PMID:19139490 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 70_70 1512.0 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 247_247 1512.0 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:6203908;Dbxref=PMID:16335952,PMID:6203908 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 396_396 1512.0 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:6203908;Dbxref=PMID:16335952,PMID:19159218,PMID:6203908 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 410_410 1512.0 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:6203908;Dbxref=PMID:16335952,PMID:6203908 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 869_869 1512.0 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952;Dbxref=PMID:14760718,PMID:16335952 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 991_991 1512.0 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12754519,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:6203908;Dbxref=PMID:12754519,PMID:16335952,PMID:19159218,PMID:6203908 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 1424_1424 1512.0 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19139490,ECO:0000269|PubMed:19159218;Dbxref=PMID:14760718,PMID:16335952,PMID:19139490,PMID:19159218 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 48_86 1512.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 251_299 1512.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 269_287 1512.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 278_278 1512.0 1475.0 retained Disulfide bond Note=Interchain (with C-431);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2430963;Dbxref=PMID:2430963 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 431_431 1512.0 1475.0 retained Disulfide bond Note=Interchain (with C-278);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2430963;Dbxref=PMID:2430963 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 470_563 1512.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2430963;Dbxref=PMID:2430963 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 595_771 1512.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2430963,ECO:0000269|PubMed:6203908;Dbxref=PMID:2430963,PMID:6203908 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 642_689 1512.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 821_849 1512.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 847_883 1512.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 921_1321 1512.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 1079_1127 1512.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 1352_1467 1512.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 693_693 1512.0 1475.0 retained Cross-link Note=Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in other proteins);Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 694_694 1512.0 1475.0 retained Cross-link Note=Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in other proteins);Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 972_975 1512.0 1475.0 retained Cross-link Note=Isoglutamyl cysteine thioester (Cys-Gln);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 639_639 1512.0 1475.0 retained Natural variant ID=VAR_026820;Note=N->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:15611997,ECO:0000269|PubMed:17974005,ECO:0000269|PubMed:2581245,ECO:0000269|Ref.3;Dbxref=dbSNP:rs226405,PMID:15489334,PMID:15611997,PMID:17974005,PMID:2581245 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 704_704 1512.0 1475.0 retained Natural variant ID=VAR_000012;Note=R->H;Dbxref=dbSNP:rs1800434 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 815_815 1512.0 1475.0 retained Natural variant ID=VAR_026821;Note=L->Q;Dbxref=dbSNP:rs3180392 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 972_972 1512.0 1475.0 retained Natural variant ID=VAR_000013;Note=Probably interferes with the activity. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1370808;Dbxref=dbSNP:rs1800433,PMID:1370808 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 1000_1000 1512.0 1475.0 retained Natural variant ID=VAR_000014;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:15611997,ECO:0000269|PubMed:1707161,ECO:0000269|PubMed:17974005,ECO:0000269|PubMed:2581245;Dbxref=dbSNP:rs669,PMID:15489334,PMID:15611997,PMID:1707161,PMID:17974005,PMID:2581245 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 63_63 1512.0 1475.0 retained Sequence conflict Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 82_82 1512.0 1475.0 retained Sequence conflict Note=D->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 350_353 1512.0 1475.0 retained Sequence conflict Note=LSFV->ACCS;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 563_563 1512.0 1475.0 retained Sequence conflict Note=C->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 844_844 1512.0 1475.0 retained Sequence conflict Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 872_872 1512.0 1475.0 retained Sequence conflict Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 1148_1148 1512.0 1475.0 retained Sequence conflict Note=A->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 1195_1195 1512.0 1475.0 retained Sequence conflict Note=H->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 128_134 1512.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 136_138 1512.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 143_151 1512.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 153_155 1512.0 1475.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 161_168 1512.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 174_182 1512.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 187_193 1512.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 201_208 1512.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 214_221 1512.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 1341_1347 1512.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 1355_1359 1512.0 1475.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 1360_1369 1512.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 1379_1384 1512.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 1389_1391 1512.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 1393_1400 1512.0 1475.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 1401_1403 1512.0 1475.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 1407_1410 1512.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 1412_1419 1512.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 1427_1434 1512.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 1445_1450 1512.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 1454_1456 1512.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9220308 - CCT5 chr5:10250033 ENST00000318602 P01023 36 36 1459_1463 1512.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 1_23 1092.0 1475.0 retained Signal peptide Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 24_1474 1092.0 1475.0 not_retained Chain ID=PRO_0000000055;Note=Alpha-2-macroglobulin;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 690_728 1092.0 1475.0 retained Region Note=Bait region Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 704_709 1092.0 1475.0 retained Region Note=Inhibitory Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 719_723 1092.0 1475.0 retained Region Note=Inhibitory Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 730_735 1092.0 1475.0 retained Region Note=Inhibitory Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 55_55 1092.0 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19139490;Dbxref=PMID:16335952,PMID:19139490 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 70_70 1092.0 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 247_247 1092.0 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:6203908;Dbxref=PMID:16335952,PMID:6203908 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 396_396 1092.0 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:6203908;Dbxref=PMID:16335952,PMID:19159218,PMID:6203908 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 410_410 1092.0 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:6203908;Dbxref=PMID:16335952,PMID:6203908 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 869_869 1092.0 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952;Dbxref=PMID:14760718,PMID:16335952 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 991_991 1092.0 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12754519,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:6203908;Dbxref=PMID:12754519,PMID:16335952,PMID:19159218,PMID:6203908 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 1424_1424 1092.0 1475.0 not_retained Glycosylation Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19139490,ECO:0000269|PubMed:19159218;Dbxref=PMID:14760718,PMID:16335952,PMID:19139490,PMID:19159218 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 48_86 1092.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 251_299 1092.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 269_287 1092.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 278_278 1092.0 1475.0 retained Disulfide bond Note=Interchain (with C-431);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2430963;Dbxref=PMID:2430963 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 431_431 1092.0 1475.0 retained Disulfide bond Note=Interchain (with C-278);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2430963;Dbxref=PMID:2430963 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 470_563 1092.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2430963;Dbxref=PMID:2430963 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 595_771 1092.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2430963,ECO:0000269|PubMed:6203908;Dbxref=PMID:2430963,PMID:6203908 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 642_689 1092.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 821_849 1092.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 847_883 1092.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 921_1321 1092.0 1475.0 not_retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 1079_1127 1092.0 1475.0 not_retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 1352_1467 1092.0 1475.0 not_retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 693_693 1092.0 1475.0 retained Cross-link Note=Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in other proteins);Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 694_694 1092.0 1475.0 retained Cross-link Note=Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in other proteins);Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 972_975 1092.0 1475.0 retained Cross-link Note=Isoglutamyl cysteine thioester (Cys-Gln);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 639_639 1092.0 1475.0 retained Natural variant ID=VAR_026820;Note=N->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:15611997,ECO:0000269|PubMed:17974005,ECO:0000269|PubMed:2581245,ECO:0000269|Ref.3;Dbxref=dbSNP:rs226405,PMID:15489334,PMID:15611997,PMID:17974005,PMID:2581245 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 704_704 1092.0 1475.0 retained Natural variant ID=VAR_000012;Note=R->H;Dbxref=dbSNP:rs1800434 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 815_815 1092.0 1475.0 retained Natural variant ID=VAR_026821;Note=L->Q;Dbxref=dbSNP:rs3180392 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 972_972 1092.0 1475.0 retained Natural variant ID=VAR_000013;Note=Probably interferes with the activity. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1370808;Dbxref=dbSNP:rs1800433,PMID:1370808 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 1000_1000 1092.0 1475.0 retained Natural variant ID=VAR_000014;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:15611997,ECO:0000269|PubMed:1707161,ECO:0000269|PubMed:17974005,ECO:0000269|PubMed:2581245;Dbxref=dbSNP:rs669,PMID:15489334,PMID:15611997,PMID:1707161,PMID:17974005,PMID:2581245 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 63_63 1092.0 1475.0 retained Sequence conflict Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 82_82 1092.0 1475.0 retained Sequence conflict Note=D->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 350_353 1092.0 1475.0 retained Sequence conflict Note=LSFV->ACCS;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 563_563 1092.0 1475.0 retained Sequence conflict Note=C->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 844_844 1092.0 1475.0 retained Sequence conflict Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 872_872 1092.0 1475.0 retained Sequence conflict Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 1148_1148 1092.0 1475.0 not_retained Sequence conflict Note=A->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 1195_1195 1092.0 1475.0 not_retained Sequence conflict Note=H->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 128_134 1092.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 136_138 1092.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 143_151 1092.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 153_155 1092.0 1475.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 161_168 1092.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 174_182 1092.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 187_193 1092.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 201_208 1092.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 214_221 1092.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 1341_1347 1092.0 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 1355_1359 1092.0 1475.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 1360_1369 1092.0 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 1379_1384 1092.0 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 1389_1391 1092.0 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 1393_1400 1092.0 1475.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 1401_1403 1092.0 1475.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 1407_1410 1092.0 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 1412_1419 1092.0 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 1427_1434 1092.0 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 1445_1450 1092.0 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 1454_1456 1092.0 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9230297 - PZP chr12:9310437 ENST00000318602 P01023 26 36 1459_1463 1092.0 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 1_23 951.3333333333334 1475.0 retained Signal peptide Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 24_1474 951.3333333333334 1475.0 not_retained Chain ID=PRO_0000000055;Note=Alpha-2-macroglobulin;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 690_728 951.3333333333334 1475.0 retained Region Note=Bait region Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 704_709 951.3333333333334 1475.0 retained Region Note=Inhibitory Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 719_723 951.3333333333334 1475.0 retained Region Note=Inhibitory Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 730_735 951.3333333333334 1475.0 retained Region Note=Inhibitory Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 55_55 951.3333333333334 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19139490;Dbxref=PMID:16335952,PMID:19139490 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 70_70 951.3333333333334 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 247_247 951.3333333333334 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:6203908;Dbxref=PMID:16335952,PMID:6203908 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 396_396 951.3333333333334 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:6203908;Dbxref=PMID:16335952,PMID:19159218,PMID:6203908 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 410_410 951.3333333333334 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:6203908;Dbxref=PMID:16335952,PMID:6203908 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 869_869 951.3333333333334 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952;Dbxref=PMID:14760718,PMID:16335952 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 991_991 951.3333333333334 1475.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12754519,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:6203908;Dbxref=PMID:12754519,PMID:16335952,PMID:19159218,PMID:6203908 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 1424_1424 951.3333333333334 1475.0 not_retained Glycosylation Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19139490,ECO:0000269|PubMed:19159218;Dbxref=PMID:14760718,PMID:16335952,PMID:19139490,PMID:19159218 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 48_86 951.3333333333334 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 251_299 951.3333333333334 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 269_287 951.3333333333334 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 278_278 951.3333333333334 1475.0 retained Disulfide bond Note=Interchain (with C-431);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2430963;Dbxref=PMID:2430963 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 431_431 951.3333333333334 1475.0 retained Disulfide bond Note=Interchain (with C-278);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2430963;Dbxref=PMID:2430963 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 470_563 951.3333333333334 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2430963;Dbxref=PMID:2430963 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 595_771 951.3333333333334 1475.0 retained Disulfide bond Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2430963,ECO:0000269|PubMed:6203908;Dbxref=PMID:2430963,PMID:6203908 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 642_689 951.3333333333334 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 821_849 951.3333333333334 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 847_883 951.3333333333334 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 921_1321 951.3333333333334 1475.0 not_retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 1079_1127 951.3333333333334 1475.0 not_retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 1352_1467 951.3333333333334 1475.0 not_retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 693_693 951.3333333333334 1475.0 retained Cross-link Note=Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in other proteins);Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 694_694 951.3333333333334 1475.0 retained Cross-link Note=Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in other proteins);Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 972_975 951.3333333333334 1475.0 not_retained Cross-link Note=Isoglutamyl cysteine thioester (Cys-Gln);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 639_639 951.3333333333334 1475.0 retained Natural variant ID=VAR_026820;Note=N->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:15611997,ECO:0000269|PubMed:17974005,ECO:0000269|PubMed:2581245,ECO:0000269|Ref.3;Dbxref=dbSNP:rs226405,PMID:15489334,PMID:15611997,PMID:17974005,PMID:2581245 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 704_704 951.3333333333334 1475.0 retained Natural variant ID=VAR_000012;Note=R->H;Dbxref=dbSNP:rs1800434 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 815_815 951.3333333333334 1475.0 retained Natural variant ID=VAR_026821;Note=L->Q;Dbxref=dbSNP:rs3180392 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 972_972 951.3333333333334 1475.0 not_retained Natural variant ID=VAR_000013;Note=Probably interferes with the activity. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1370808;Dbxref=dbSNP:rs1800433,PMID:1370808 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 1000_1000 951.3333333333334 1475.0 not_retained Natural variant ID=VAR_000014;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:15611997,ECO:0000269|PubMed:1707161,ECO:0000269|PubMed:17974005,ECO:0000269|PubMed:2581245;Dbxref=dbSNP:rs669,PMID:15489334,PMID:15611997,PMID:1707161,PMID:17974005,PMID:2581245 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 63_63 951.3333333333334 1475.0 retained Sequence conflict Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 82_82 951.3333333333334 1475.0 retained Sequence conflict Note=D->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 350_353 951.3333333333334 1475.0 retained Sequence conflict Note=LSFV->ACCS;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 563_563 951.3333333333334 1475.0 retained Sequence conflict Note=C->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 844_844 951.3333333333334 1475.0 retained Sequence conflict Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 872_872 951.3333333333334 1475.0 retained Sequence conflict Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 1148_1148 951.3333333333334 1475.0 not_retained Sequence conflict Note=A->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 1195_1195 951.3333333333334 1475.0 not_retained Sequence conflict Note=H->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 128_134 951.3333333333334 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 136_138 951.3333333333334 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 143_151 951.3333333333334 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 153_155 951.3333333333334 1475.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 161_168 951.3333333333334 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 174_182 951.3333333333334 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 187_193 951.3333333333334 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 201_208 951.3333333333334 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 214_221 951.3333333333334 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 1341_1347 951.3333333333334 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 1355_1359 951.3333333333334 1475.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 1360_1369 951.3333333333334 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 1379_1384 951.3333333333334 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 1389_1391 951.3333333333334 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 1393_1400 951.3333333333334 1475.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 1401_1403 951.3333333333334 1475.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 1407_1410 951.3333333333334 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 1412_1419 951.3333333333334 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 1427_1434 951.3333333333334 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 1445_1450 951.3333333333334 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 1454_1456 951.3333333333334 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9232690 - SERPINA1 chr14:94844977 ENST00000318602 P01023 23 36 1459_1463 951.3333333333334 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 1_23 823.0 1475.0 retained Signal peptide Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 24_1474 823.0 1475.0 not_retained Chain ID=PRO_0000000055;Note=Alpha-2-macroglobulin;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 690_728 823.0 1475.0 retained Region Note=Bait region Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 704_709 823.0 1475.0 retained Region Note=Inhibitory Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 719_723 823.0 1475.0 retained Region Note=Inhibitory Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 730_735 823.0 1475.0 retained Region Note=Inhibitory Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 55_55 823.0 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19139490;Dbxref=PMID:16335952,PMID:19139490 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 70_70 823.0 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 247_247 823.0 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:6203908;Dbxref=PMID:16335952,PMID:6203908 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 396_396 823.0 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:6203908;Dbxref=PMID:16335952,PMID:19159218,PMID:6203908 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 410_410 823.0 1475.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:6203908;Dbxref=PMID:16335952,PMID:6203908 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 869_869 823.0 1475.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952;Dbxref=PMID:14760718,PMID:16335952 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 991_991 823.0 1475.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12754519,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19159218,ECO:0000269|PubMed:6203908;Dbxref=PMID:12754519,PMID:16335952,PMID:19159218,PMID:6203908 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 1424_1424 823.0 1475.0 not_retained Glycosylation Note=N-linked (GlcNAc...) (complex) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14760718,ECO:0000269|PubMed:16335952,ECO:0000269|PubMed:19139490,ECO:0000269|PubMed:19159218;Dbxref=PMID:14760718,PMID:16335952,PMID:19139490,PMID:19159218 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 48_86 823.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 251_299 823.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 269_287 823.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 278_278 823.0 1475.0 retained Disulfide bond Note=Interchain (with C-431);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2430963;Dbxref=PMID:2430963 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 431_431 823.0 1475.0 retained Disulfide bond Note=Interchain (with C-278);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2430963;Dbxref=PMID:2430963 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 470_563 823.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2430963;Dbxref=PMID:2430963 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 595_771 823.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2430963,ECO:0000269|PubMed:6203908;Dbxref=PMID:2430963,PMID:6203908 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 642_689 823.0 1475.0 retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 821_849 823.0 1475.0 not_retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 847_883 823.0 1475.0 not_retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 921_1321 823.0 1475.0 not_retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 1079_1127 823.0 1475.0 not_retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 1352_1467 823.0 1475.0 not_retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 693_693 823.0 1475.0 retained Cross-link Note=Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in other proteins);Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 694_694 823.0 1475.0 retained Cross-link Note=Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in other proteins);Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 972_975 823.0 1475.0 not_retained Cross-link Note=Isoglutamyl cysteine thioester (Cys-Gln);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6203908;Dbxref=PMID:6203908 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 639_639 823.0 1475.0 retained Natural variant ID=VAR_026820;Note=N->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:15611997,ECO:0000269|PubMed:17974005,ECO:0000269|PubMed:2581245,ECO:0000269|Ref.3;Dbxref=dbSNP:rs226405,PMID:15489334,PMID:15611997,PMID:17974005,PMID:2581245 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 704_704 823.0 1475.0 retained Natural variant ID=VAR_000012;Note=R->H;Dbxref=dbSNP:rs1800434 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 815_815 823.0 1475.0 retained Natural variant ID=VAR_026821;Note=L->Q;Dbxref=dbSNP:rs3180392 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 972_972 823.0 1475.0 not_retained Natural variant ID=VAR_000013;Note=Probably interferes with the activity. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1370808;Dbxref=dbSNP:rs1800433,PMID:1370808 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 1000_1000 823.0 1475.0 not_retained Natural variant ID=VAR_000014;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:15611997,ECO:0000269|PubMed:1707161,ECO:0000269|PubMed:17974005,ECO:0000269|PubMed:2581245;Dbxref=dbSNP:rs669,PMID:15489334,PMID:15611997,PMID:1707161,PMID:17974005,PMID:2581245 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 63_63 823.0 1475.0 retained Sequence conflict Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 82_82 823.0 1475.0 retained Sequence conflict Note=D->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 350_353 823.0 1475.0 retained Sequence conflict Note=LSFV->ACCS;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 563_563 823.0 1475.0 retained Sequence conflict Note=C->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 844_844 823.0 1475.0 not_retained Sequence conflict Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 872_872 823.0 1475.0 not_retained Sequence conflict Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 1148_1148 823.0 1475.0 not_retained Sequence conflict Note=A->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 1195_1195 823.0 1475.0 not_retained Sequence conflict Note=H->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 128_134 823.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 136_138 823.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 143_151 823.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 153_155 823.0 1475.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 161_168 823.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 174_182 823.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 187_193 823.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 201_208 823.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 214_221 823.0 1475.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2P9R Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 1341_1347 823.0 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 1355_1359 823.0 1475.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 1360_1369 823.0 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 1379_1384 823.0 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 1389_1391 823.0 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 1393_1400 823.0 1475.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 1401_1403 823.0 1475.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 1407_1410 823.0 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 1412_1419 823.0 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 1427_1434 823.0 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 1445_1450 823.0 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 1454_1456 823.0 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2M chr12:9243797 - PZP chr12:9315244 ENST00000318602 P01023 19 36 1459_1463 823.0 1475.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1BV8 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 1_17 214.33333333333334 1617.0 retained Signal peptide Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 18_1454 214.33333333333334 1617.0 not_retained Chain ID=PRO_0000318074;Note=Alpha-2-macroglobulin-like protein 1;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 695_726 214.33333333333334 1617.0 not_retained Region Note=Bait region;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 120_120 214.33333333333334 1617.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 281_281 214.33333333333334 1617.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 409_409 214.33333333333334 1617.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 857_857 214.33333333333334 1617.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 1020_1020 214.33333333333334 1617.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 40_78 214.33333333333334 1617.0 retained Disulfide bond Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P01023 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 241_291 214.33333333333334 1617.0 not_retained Disulfide bond Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P01023 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 259_279 214.33333333333334 1617.0 not_retained Disulfide bond Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P01023 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 464_557 214.33333333333334 1617.0 not_retained Disulfide bond Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P01023 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 589_769 214.33333333333334 1617.0 not_retained Disulfide bond Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P01023 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 819_847 214.33333333333334 1617.0 not_retained Disulfide bond Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P01023 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 845_881 214.33333333333334 1617.0 not_retained Disulfide bond Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P01023 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 919_1307 214.33333333333334 1617.0 not_retained Disulfide bond Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P01023 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 1075_1123 214.33333333333334 1617.0 not_retained Disulfide bond Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P01023 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 1338_1453 214.33333333333334 1617.0 not_retained Disulfide bond Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P01023 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 970_973 214.33333333333334 1617.0 not_retained Cross-link Note=Isoglutamyl cysteine thioester (Cys-Gln);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P01023 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 2_492 214.33333333333334 1617.0 not_retained Alternative sequence ID=VSP_057135;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 207_207 214.33333333333334 1617.0 retained Natural variant ID=VAR_055463;Note=G->R;Dbxref=dbSNP:rs11047499 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 255_1454 214.33333333333334 1617.0 not_retained Natural variant ID=VAR_081009;Note=Risk factor for otitis media. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26121085;Dbxref=PMID:26121085 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 296_296 214.33333333333334 1617.0 not_retained Natural variant ID=VAR_081010;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26121085;Dbxref=dbSNP:rs192888493,PMID:26121085 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 356_356 214.33333333333334 1617.0 not_retained Natural variant ID=VAR_081011;Note=May be a risk factor for otitis media. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26121085;Dbxref=dbSNP:rs863224953,PMID:26121085 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 850_850 214.33333333333334 1617.0 not_retained Natural variant ID=VAR_059083;Note=D->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:17974005,ECO:0000269|Ref.4;Dbxref=dbSNP:rs1860926,PMID:14702039,PMID:17974005 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 893_1454 214.33333333333334 1617.0 not_retained Natural variant ID=VAR_081012;Note=Risk factor for otitis media. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26121085;Dbxref=PMID:26121085 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 970_970 214.33333333333334 1617.0 not_retained Natural variant ID=VAR_055464;Note=C->Y;Dbxref=dbSNP:rs1558526 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 972_1454 214.33333333333334 1617.0 not_retained Natural variant ID=VAR_081013;Note=Risk factor for otitis media. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26121085;Dbxref=PMID:26121085 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 1001_1001 214.33333333333334 1617.0 not_retained Natural variant ID=VAR_081014;Note=May be a risk factor for otitis media. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26121085;Dbxref=dbSNP:rs201725377,PMID:26121085 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 1122_1122 214.33333333333334 1617.0 not_retained Natural variant ID=VAR_071854;Note=R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:17974005,ECO:0000269|Ref.4;Dbxref=dbSNP:rs1860967,PMID:14702039,PMID:17974005 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 1131_1131 214.33333333333334 1617.0 not_retained Natural variant ID=VAR_055465;Note=T->M;Dbxref=dbSNP:rs7959680 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 1229_1229 214.33333333333334 1617.0 not_retained Natural variant ID=VAR_059084;Note=H->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:17974005,ECO:0000269|Ref.4;Dbxref=dbSNP:rs10219561,PMID:14702039,PMID:17974005 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 1257_1257 214.33333333333334 1617.0 not_retained Natural variant ID=VAR_071855;Note=M->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:17974005,ECO:0000269|Ref.4;Dbxref=dbSNP:rs7308811,PMID:14702039,PMID:17974005 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 1312_1312 214.33333333333334 1617.0 not_retained Natural variant ID=VAR_071856;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs201083574,PMID:14702039 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 1412_1412 214.33333333333334 1617.0 not_retained Natural variant ID=VAR_055466;Note=T->A;Dbxref=dbSNP:rs7315591 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 1431_1431 214.33333333333334 1617.0 not_retained Natural variant ID=VAR_081015;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26121085;Dbxref=dbSNP:rs863224955,PMID:26121085 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 733_733 214.33333333333334 1617.0 not_retained Sequence conflict Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 733_733 214.33333333333334 1617.0 not_retained Sequence conflict Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 748_748 214.33333333333334 1617.0 not_retained Sequence conflict Note=G->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 1150_1150 214.33333333333334 1617.0 not_retained Sequence conflict Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 1248_1248 214.33333333333334 1617.0 not_retained Sequence conflict Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene A2ML1 chr12:8988262 + RBM39 chr20:34301018 ENST00000299698 A8K2U0 6 36 1452_1452 214.33333333333334 1617.0 not_retained Sequence conflict Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 1_961 788.3333333333334 962.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 46_315 788.3333333333334 962.0 retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 52_60 788.3333333333334 962.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 823_960 788.3333333333334 962.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 12_42 788.3333333333334 962.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 397_614 788.3333333333334 962.0 retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 658_663 788.3333333333334 962.0 retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 176_176 788.3333333333334 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 74_74 788.3333333333334 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 1_1 788.3333333333334 962.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 14_14 788.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 234_234 788.3333333333334 962.0 retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 235_235 788.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 354_354 788.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 389_389 788.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 391_391 788.3333333333334 962.0 retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 441_441 788.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 606_606 788.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 618_618 788.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 620_620 788.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 623_623 788.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 624_624 788.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 637_637 788.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 650_650 788.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 653_653 788.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 687_687 788.3333333333334 962.0 retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 731_731 788.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 846_846 788.3333333333334 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 937_937 788.3333333333334 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 938_938 788.3333333333334 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 823_961 788.3333333333334 962.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 59_59 788.3333333333334 962.0 retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 509_509 788.3333333333334 962.0 retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 533_533 788.3333333333334 962.0 retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 603_603 788.3333333333334 962.0 retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 694_694 788.3333333333334 962.0 retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 725_725 788.3333333333334 962.0 retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 771_771 788.3333333333334 962.0 retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 835_835 788.3333333333334 962.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 74_74 788.3333333333334 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 176_176 788.3333333333334 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 777_779 788.3333333333334 962.0 retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 31_34 788.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 38_41 788.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 44_55 788.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 58_64 788.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 70_78 788.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 81_97 788.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 106_113 788.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 120_127 788.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 134_139 788.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 142_144 788.3333333333334 962.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 148_167 788.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 168_170 788.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 179_181 788.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 182_184 788.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 190_192 788.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 205_208 788.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 210_220 788.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 223_225 788.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 228_231 788.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 242_257 788.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 261_264 788.3333333333334 962.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 266_271 788.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 284_293 788.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 298_300 788.3333333333334 962.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 304_315 788.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 17 22 339_344 788.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 1_961 788.3333333333334 864.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 46_315 788.3333333333334 864.0 retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 52_60 788.3333333333334 864.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 823_960 788.3333333333334 864.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 12_42 788.3333333333334 864.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 397_614 788.3333333333334 864.0 retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 658_663 788.3333333333334 864.0 retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 176_176 788.3333333333334 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 74_74 788.3333333333334 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 1_1 788.3333333333334 864.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 14_14 788.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 234_234 788.3333333333334 864.0 retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 235_235 788.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 354_354 788.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 389_389 788.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 391_391 788.3333333333334 864.0 retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 441_441 788.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 606_606 788.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 618_618 788.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 620_620 788.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 623_623 788.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 624_624 788.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 637_637 788.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 650_650 788.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 653_653 788.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 687_687 788.3333333333334 864.0 retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 731_731 788.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 846_846 788.3333333333334 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 937_937 788.3333333333334 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 938_938 788.3333333333334 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 823_961 788.3333333333334 864.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 59_59 788.3333333333334 864.0 retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 509_509 788.3333333333334 864.0 retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 533_533 788.3333333333334 864.0 retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 603_603 788.3333333333334 864.0 retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 694_694 788.3333333333334 864.0 retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 725_725 788.3333333333334 864.0 retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 771_771 788.3333333333334 864.0 retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 835_835 788.3333333333334 864.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 74_74 788.3333333333334 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 176_176 788.3333333333334 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 777_779 788.3333333333334 864.0 retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 31_34 788.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 38_41 788.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 44_55 788.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 58_64 788.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 70_78 788.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 81_97 788.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 106_113 788.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 120_127 788.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 134_139 788.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 142_144 788.3333333333334 864.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 148_167 788.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 168_170 788.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 179_181 788.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 182_184 788.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 190_192 788.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 205_208 788.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 210_220 788.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 223_225 788.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 228_231 788.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 242_257 788.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 261_264 788.3333333333334 864.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 266_271 788.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 284_293 788.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 298_300 788.3333333333334 864.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 304_315 788.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69723117 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 17 18 339_344 788.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 1_961 756.3333333333334 962.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 46_315 756.3333333333334 962.0 retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 52_60 756.3333333333334 962.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 823_960 756.3333333333334 962.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 12_42 756.3333333333334 962.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 397_614 756.3333333333334 962.0 retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 658_663 756.3333333333334 962.0 retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 176_176 756.3333333333334 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 74_74 756.3333333333334 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 1_1 756.3333333333334 962.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 14_14 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 234_234 756.3333333333334 962.0 retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 235_235 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 354_354 756.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 389_389 756.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 391_391 756.3333333333334 962.0 retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 441_441 756.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 606_606 756.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 618_618 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 620_620 756.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 623_623 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 624_624 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 637_637 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 650_650 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 653_653 756.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 687_687 756.3333333333334 962.0 retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 731_731 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 846_846 756.3333333333334 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 937_937 756.3333333333334 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 938_938 756.3333333333334 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 823_961 756.3333333333334 962.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 59_59 756.3333333333334 962.0 retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 509_509 756.3333333333334 962.0 retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 533_533 756.3333333333334 962.0 retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 603_603 756.3333333333334 962.0 retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 694_694 756.3333333333334 962.0 retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 725_725 756.3333333333334 962.0 retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 771_771 756.3333333333334 962.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 835_835 756.3333333333334 962.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 74_74 756.3333333333334 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 176_176 756.3333333333334 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 777_779 756.3333333333334 962.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 31_34 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 38_41 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 44_55 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 58_64 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 70_78 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 81_97 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 106_113 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 120_127 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 134_139 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 142_144 756.3333333333334 962.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 148_167 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 168_170 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 179_181 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 182_184 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 190_192 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 205_208 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 210_220 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 223_225 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 228_231 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 242_257 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 261_264 756.3333333333334 962.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 266_271 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 284_293 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 298_300 756.3333333333334 962.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 304_315 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000409085 Q2M2I8 16 22 339_344 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 1_961 756.3333333333334 864.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 46_315 756.3333333333334 864.0 retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 52_60 756.3333333333334 864.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 823_960 756.3333333333334 864.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 12_42 756.3333333333334 864.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 397_614 756.3333333333334 864.0 retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 658_663 756.3333333333334 864.0 retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 176_176 756.3333333333334 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 74_74 756.3333333333334 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 1_1 756.3333333333334 864.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 14_14 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 234_234 756.3333333333334 864.0 retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 235_235 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 354_354 756.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 389_389 756.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 391_391 756.3333333333334 864.0 retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 441_441 756.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 606_606 756.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 618_618 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 620_620 756.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 623_623 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 624_624 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 637_637 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 650_650 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 653_653 756.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 687_687 756.3333333333334 864.0 retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 731_731 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 846_846 756.3333333333334 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 937_937 756.3333333333334 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 938_938 756.3333333333334 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 823_961 756.3333333333334 864.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 59_59 756.3333333333334 864.0 retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 509_509 756.3333333333334 864.0 retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 533_533 756.3333333333334 864.0 retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 603_603 756.3333333333334 864.0 retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 694_694 756.3333333333334 864.0 retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 725_725 756.3333333333334 864.0 retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 771_771 756.3333333333334 864.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 835_835 756.3333333333334 864.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 74_74 756.3333333333334 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 176_176 756.3333333333334 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 777_779 756.3333333333334 864.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 31_34 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 38_41 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 44_55 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 58_64 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 70_78 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 81_97 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 106_113 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 120_127 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 134_139 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 142_144 756.3333333333334 864.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 148_167 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 168_170 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 179_181 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 182_184 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 190_192 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 205_208 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 210_220 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 223_225 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 228_231 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 242_257 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 261_264 756.3333333333334 864.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 266_271 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 284_293 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 298_300 756.3333333333334 864.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 304_315 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - FNTA chr8:42919243 ENST00000406297 Q2M2I8 16 18 339_344 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 1_961 756.3333333333334 962.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 46_315 756.3333333333334 962.0 retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 52_60 756.3333333333334 962.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 823_960 756.3333333333334 962.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 12_42 756.3333333333334 962.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 397_614 756.3333333333334 962.0 retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 658_663 756.3333333333334 962.0 retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 176_176 756.3333333333334 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 74_74 756.3333333333334 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 1_1 756.3333333333334 962.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 14_14 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 234_234 756.3333333333334 962.0 retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 235_235 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 354_354 756.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 389_389 756.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 391_391 756.3333333333334 962.0 retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 441_441 756.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 606_606 756.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 618_618 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 620_620 756.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 623_623 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 624_624 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 637_637 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 650_650 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 653_653 756.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 687_687 756.3333333333334 962.0 retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 731_731 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 846_846 756.3333333333334 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 937_937 756.3333333333334 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 938_938 756.3333333333334 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 823_961 756.3333333333334 962.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 59_59 756.3333333333334 962.0 retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 509_509 756.3333333333334 962.0 retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 533_533 756.3333333333334 962.0 retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 603_603 756.3333333333334 962.0 retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 694_694 756.3333333333334 962.0 retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 725_725 756.3333333333334 962.0 retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 771_771 756.3333333333334 962.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 835_835 756.3333333333334 962.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 74_74 756.3333333333334 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 176_176 756.3333333333334 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 777_779 756.3333333333334 962.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 31_34 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 38_41 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 44_55 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 58_64 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 70_78 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 81_97 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 106_113 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 120_127 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 134_139 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 142_144 756.3333333333334 962.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 148_167 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 168_170 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 179_181 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 182_184 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 190_192 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 205_208 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 210_220 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 223_225 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 228_231 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 242_257 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 261_264 756.3333333333334 962.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 266_271 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 284_293 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 298_300 756.3333333333334 962.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 304_315 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000409085 Q2M2I8 16 22 339_344 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 1_961 756.3333333333334 864.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 46_315 756.3333333333334 864.0 retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 52_60 756.3333333333334 864.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 823_960 756.3333333333334 864.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 12_42 756.3333333333334 864.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 397_614 756.3333333333334 864.0 retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 658_663 756.3333333333334 864.0 retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 176_176 756.3333333333334 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 74_74 756.3333333333334 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 1_1 756.3333333333334 864.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 14_14 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 234_234 756.3333333333334 864.0 retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 235_235 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 354_354 756.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 389_389 756.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 391_391 756.3333333333334 864.0 retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 441_441 756.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 606_606 756.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 618_618 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 620_620 756.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 623_623 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 624_624 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 637_637 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 650_650 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 653_653 756.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 687_687 756.3333333333334 864.0 retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 731_731 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 846_846 756.3333333333334 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 937_937 756.3333333333334 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 938_938 756.3333333333334 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 823_961 756.3333333333334 864.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 59_59 756.3333333333334 864.0 retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 509_509 756.3333333333334 864.0 retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 533_533 756.3333333333334 864.0 retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 603_603 756.3333333333334 864.0 retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 694_694 756.3333333333334 864.0 retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 725_725 756.3333333333334 864.0 retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 771_771 756.3333333333334 864.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 835_835 756.3333333333334 864.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 74_74 756.3333333333334 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 176_176 756.3333333333334 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 777_779 756.3333333333334 864.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 31_34 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 38_41 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 44_55 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 58_64 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 70_78 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 81_97 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 106_113 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 120_127 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 134_139 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 142_144 756.3333333333334 864.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 148_167 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 168_170 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 179_181 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 182_184 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 190_192 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 205_208 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 210_220 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 223_225 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 228_231 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 242_257 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 261_264 756.3333333333334 864.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 266_271 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 284_293 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 298_300 756.3333333333334 864.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 304_315 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732700 - NOP58 chr2:203160396 ENST00000406297 Q2M2I8 16 18 339_344 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 1_961 756.3333333333334 962.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 46_315 756.3333333333334 962.0 retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 52_60 756.3333333333334 962.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 823_960 756.3333333333334 962.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 12_42 756.3333333333334 962.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 397_614 756.3333333333334 962.0 retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 658_663 756.3333333333334 962.0 retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 176_176 756.3333333333334 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 74_74 756.3333333333334 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 1_1 756.3333333333334 962.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 14_14 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 234_234 756.3333333333334 962.0 retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 235_235 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 354_354 756.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 389_389 756.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 391_391 756.3333333333334 962.0 retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 441_441 756.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 606_606 756.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 618_618 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 620_620 756.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 623_623 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 624_624 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 637_637 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 650_650 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 653_653 756.3333333333334 962.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 687_687 756.3333333333334 962.0 retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 731_731 756.3333333333334 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 846_846 756.3333333333334 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 937_937 756.3333333333334 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 938_938 756.3333333333334 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 823_961 756.3333333333334 962.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 59_59 756.3333333333334 962.0 retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 509_509 756.3333333333334 962.0 retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 533_533 756.3333333333334 962.0 retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 603_603 756.3333333333334 962.0 retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 694_694 756.3333333333334 962.0 retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 725_725 756.3333333333334 962.0 retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 771_771 756.3333333333334 962.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 835_835 756.3333333333334 962.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 74_74 756.3333333333334 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 176_176 756.3333333333334 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 777_779 756.3333333333334 962.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 31_34 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 38_41 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 44_55 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 58_64 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 70_78 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 81_97 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 106_113 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 120_127 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 134_139 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 142_144 756.3333333333334 962.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 148_167 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 168_170 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 179_181 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 182_184 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 190_192 756.3333333333334 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 205_208 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 210_220 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 223_225 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 228_231 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 242_257 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 261_264 756.3333333333334 962.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 266_271 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 284_293 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 298_300 756.3333333333334 962.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 304_315 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000409085 Q2M2I8 16 22 339_344 756.3333333333334 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 1_961 756.3333333333334 864.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 46_315 756.3333333333334 864.0 retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 52_60 756.3333333333334 864.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 823_960 756.3333333333334 864.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 12_42 756.3333333333334 864.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 397_614 756.3333333333334 864.0 retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 658_663 756.3333333333334 864.0 retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 176_176 756.3333333333334 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 74_74 756.3333333333334 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 1_1 756.3333333333334 864.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 14_14 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 234_234 756.3333333333334 864.0 retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 235_235 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 354_354 756.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 389_389 756.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 391_391 756.3333333333334 864.0 retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 441_441 756.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 606_606 756.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 618_618 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 620_620 756.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 623_623 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 624_624 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 637_637 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 650_650 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 653_653 756.3333333333334 864.0 retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 687_687 756.3333333333334 864.0 retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 731_731 756.3333333333334 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 846_846 756.3333333333334 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 937_937 756.3333333333334 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 938_938 756.3333333333334 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 823_961 756.3333333333334 864.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 59_59 756.3333333333334 864.0 retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 509_509 756.3333333333334 864.0 retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 533_533 756.3333333333334 864.0 retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 603_603 756.3333333333334 864.0 retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 694_694 756.3333333333334 864.0 retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 725_725 756.3333333333334 864.0 retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 771_771 756.3333333333334 864.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 835_835 756.3333333333334 864.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 74_74 756.3333333333334 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 176_176 756.3333333333334 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 777_779 756.3333333333334 864.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 31_34 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 38_41 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 44_55 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 58_64 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 70_78 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 81_97 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 106_113 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 120_127 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 134_139 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 142_144 756.3333333333334 864.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 148_167 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 168_170 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 179_181 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 182_184 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 190_192 756.3333333333334 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 205_208 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 210_220 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 223_225 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 228_231 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 242_257 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 261_264 756.3333333333334 864.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 266_271 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 284_293 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 298_300 756.3333333333334 864.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 304_315 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69732701 - WFDC13 chr20:44333083 ENST00000406297 Q2M2I8 16 18 339_344 756.3333333333334 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 1_961 94.0 962.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 46_315 94.0 962.0 not_retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 52_60 94.0 962.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 823_960 94.0 962.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 12_42 94.0 962.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 397_614 94.0 962.0 not_retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 658_663 94.0 962.0 not_retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 176_176 94.0 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 74_74 94.0 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 1_1 94.0 962.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 14_14 94.0 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 234_234 94.0 962.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 235_235 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 354_354 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 389_389 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 391_391 94.0 962.0 not_retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 441_441 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 606_606 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 618_618 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 620_620 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 623_623 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 624_624 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 637_637 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 650_650 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 653_653 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 687_687 94.0 962.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 731_731 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 846_846 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 937_937 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 938_938 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 823_961 94.0 962.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 59_59 94.0 962.0 retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 509_509 94.0 962.0 not_retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 533_533 94.0 962.0 not_retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 603_603 94.0 962.0 not_retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 694_694 94.0 962.0 not_retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 725_725 94.0 962.0 not_retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 771_771 94.0 962.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 835_835 94.0 962.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 74_74 94.0 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 176_176 94.0 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 777_779 94.0 962.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 31_34 94.0 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 38_41 94.0 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 44_55 94.0 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 58_64 94.0 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 70_78 94.0 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 81_97 94.0 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 106_113 94.0 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 120_127 94.0 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 134_139 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 142_144 94.0 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 148_167 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 168_170 94.0 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 179_181 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 182_184 94.0 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 190_192 94.0 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 205_208 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 210_220 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 223_225 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 228_231 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 242_257 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 261_264 94.0 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 266_271 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 284_293 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 298_300 94.0 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 304_315 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 339_344 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 1_961 94.0 864.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 46_315 94.0 864.0 not_retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 52_60 94.0 864.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 823_960 94.0 864.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 12_42 94.0 864.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 397_614 94.0 864.0 not_retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 658_663 94.0 864.0 not_retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 176_176 94.0 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 74_74 94.0 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 1_1 94.0 864.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 14_14 94.0 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 234_234 94.0 864.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 235_235 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 354_354 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 389_389 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 391_391 94.0 864.0 not_retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 441_441 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 606_606 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 618_618 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 620_620 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 623_623 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 624_624 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 637_637 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 650_650 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 653_653 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 687_687 94.0 864.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 731_731 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 846_846 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 937_937 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 938_938 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 823_961 94.0 864.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 59_59 94.0 864.0 retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 509_509 94.0 864.0 not_retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 533_533 94.0 864.0 not_retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 603_603 94.0 864.0 not_retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 694_694 94.0 864.0 not_retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 725_725 94.0 864.0 not_retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 771_771 94.0 864.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 835_835 94.0 864.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 74_74 94.0 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 176_176 94.0 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 777_779 94.0 864.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 31_34 94.0 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 38_41 94.0 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 44_55 94.0 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 58_64 94.0 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 70_78 94.0 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 81_97 94.0 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 106_113 94.0 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 120_127 94.0 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 134_139 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 142_144 94.0 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 148_167 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 168_170 94.0 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 179_181 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 182_184 94.0 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 190_192 94.0 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 205_208 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 210_220 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 223_225 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 228_231 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 242_257 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 261_264 94.0 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 266_271 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 284_293 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 298_300 94.0 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 304_315 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783991 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 339_344 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 1_961 94.0 962.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 46_315 94.0 962.0 not_retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 52_60 94.0 962.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 823_960 94.0 962.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 12_42 94.0 962.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 397_614 94.0 962.0 not_retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 658_663 94.0 962.0 not_retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 176_176 94.0 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 74_74 94.0 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 1_1 94.0 962.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 14_14 94.0 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 234_234 94.0 962.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 235_235 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 354_354 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 389_389 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 391_391 94.0 962.0 not_retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 441_441 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 606_606 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 618_618 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 620_620 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 623_623 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 624_624 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 637_637 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 650_650 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 653_653 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 687_687 94.0 962.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 731_731 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 846_846 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 937_937 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 938_938 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 823_961 94.0 962.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 59_59 94.0 962.0 retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 509_509 94.0 962.0 not_retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 533_533 94.0 962.0 not_retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 603_603 94.0 962.0 not_retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 694_694 94.0 962.0 not_retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 725_725 94.0 962.0 not_retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 771_771 94.0 962.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 835_835 94.0 962.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 74_74 94.0 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 176_176 94.0 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 777_779 94.0 962.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 31_34 94.0 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 38_41 94.0 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 44_55 94.0 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 58_64 94.0 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 70_78 94.0 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 81_97 94.0 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 106_113 94.0 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 120_127 94.0 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 134_139 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 142_144 94.0 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 148_167 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 168_170 94.0 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 179_181 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 182_184 94.0 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 190_192 94.0 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 205_208 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 210_220 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 223_225 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 228_231 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 242_257 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 261_264 94.0 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 266_271 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 284_293 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 298_300 94.0 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 304_315 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000409085 Q2M2I8 3 22 339_344 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 1_961 94.0 864.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 46_315 94.0 864.0 not_retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 52_60 94.0 864.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 823_960 94.0 864.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 12_42 94.0 864.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 397_614 94.0 864.0 not_retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 658_663 94.0 864.0 not_retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 176_176 94.0 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 74_74 94.0 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 1_1 94.0 864.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 14_14 94.0 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 234_234 94.0 864.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 235_235 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 354_354 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 389_389 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 391_391 94.0 864.0 not_retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 441_441 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 606_606 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 618_618 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 620_620 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 623_623 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 624_624 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 637_637 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 650_650 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 653_653 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 687_687 94.0 864.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 731_731 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 846_846 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 937_937 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 938_938 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 823_961 94.0 864.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 59_59 94.0 864.0 retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 509_509 94.0 864.0 not_retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 533_533 94.0 864.0 not_retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 603_603 94.0 864.0 not_retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 694_694 94.0 864.0 not_retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 725_725 94.0 864.0 not_retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 771_771 94.0 864.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 835_835 94.0 864.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 74_74 94.0 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 176_176 94.0 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 777_779 94.0 864.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 31_34 94.0 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 38_41 94.0 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 44_55 94.0 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 58_64 94.0 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 70_78 94.0 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 81_97 94.0 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 106_113 94.0 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 120_127 94.0 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 134_139 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 142_144 94.0 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 148_167 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 168_170 94.0 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 179_181 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 182_184 94.0 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 190_192 94.0 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 205_208 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 210_220 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 223_225 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 228_231 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 242_257 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 261_264 94.0 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 266_271 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 284_293 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 298_300 94.0 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 304_315 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - C2orf42 chr2:70377696 ENST00000406297 Q2M2I8 3 18 339_344 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 1_961 94.0 962.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 46_315 94.0 962.0 not_retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 52_60 94.0 962.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 823_960 94.0 962.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 12_42 94.0 962.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 397_614 94.0 962.0 not_retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 658_663 94.0 962.0 not_retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 176_176 94.0 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 74_74 94.0 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 1_1 94.0 962.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 14_14 94.0 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 234_234 94.0 962.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 235_235 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 354_354 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 389_389 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 391_391 94.0 962.0 not_retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 441_441 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 606_606 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 618_618 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 620_620 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 623_623 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 624_624 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 637_637 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 650_650 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 653_653 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 687_687 94.0 962.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 731_731 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 846_846 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 937_937 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 938_938 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 823_961 94.0 962.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 59_59 94.0 962.0 retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 509_509 94.0 962.0 not_retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 533_533 94.0 962.0 not_retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 603_603 94.0 962.0 not_retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 694_694 94.0 962.0 not_retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 725_725 94.0 962.0 not_retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 771_771 94.0 962.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 835_835 94.0 962.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 74_74 94.0 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 176_176 94.0 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 777_779 94.0 962.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 31_34 94.0 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 38_41 94.0 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 44_55 94.0 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 58_64 94.0 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 70_78 94.0 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 81_97 94.0 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 106_113 94.0 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 120_127 94.0 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 134_139 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 142_144 94.0 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 148_167 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 168_170 94.0 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 179_181 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 182_184 94.0 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 190_192 94.0 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 205_208 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 210_220 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 223_225 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 228_231 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 242_257 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 261_264 94.0 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 266_271 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 284_293 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 298_300 94.0 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 304_315 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000409085 Q2M2I8 3 22 339_344 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 1_961 94.0 864.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 46_315 94.0 864.0 not_retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 52_60 94.0 864.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 823_960 94.0 864.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 12_42 94.0 864.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 397_614 94.0 864.0 not_retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 658_663 94.0 864.0 not_retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 176_176 94.0 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 74_74 94.0 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 1_1 94.0 864.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 14_14 94.0 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 234_234 94.0 864.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 235_235 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 354_354 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 389_389 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 391_391 94.0 864.0 not_retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 441_441 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 606_606 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 618_618 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 620_620 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 623_623 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 624_624 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 637_637 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 650_650 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 653_653 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 687_687 94.0 864.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 731_731 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 846_846 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 937_937 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 938_938 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 823_961 94.0 864.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 59_59 94.0 864.0 retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 509_509 94.0 864.0 not_retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 533_533 94.0 864.0 not_retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 603_603 94.0 864.0 not_retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 694_694 94.0 864.0 not_retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 725_725 94.0 864.0 not_retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 771_771 94.0 864.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 835_835 94.0 864.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 74_74 94.0 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 176_176 94.0 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 777_779 94.0 864.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 31_34 94.0 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 38_41 94.0 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 44_55 94.0 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 58_64 94.0 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 70_78 94.0 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 81_97 94.0 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 106_113 94.0 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 120_127 94.0 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 134_139 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 142_144 94.0 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 148_167 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 168_170 94.0 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 179_181 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 182_184 94.0 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 190_192 94.0 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 205_208 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 210_220 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 223_225 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 228_231 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 242_257 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 261_264 94.0 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 266_271 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 284_293 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 298_300 94.0 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 304_315 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - LHX2 chr9:126776240 ENST00000406297 Q2M2I8 3 18 339_344 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 1_961 94.0 962.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 46_315 94.0 962.0 not_retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 52_60 94.0 962.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 823_960 94.0 962.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 12_42 94.0 962.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 397_614 94.0 962.0 not_retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 658_663 94.0 962.0 not_retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 176_176 94.0 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 74_74 94.0 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 1_1 94.0 962.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 14_14 94.0 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 234_234 94.0 962.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 235_235 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 354_354 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 389_389 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 391_391 94.0 962.0 not_retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 441_441 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 606_606 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 618_618 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 620_620 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 623_623 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 624_624 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 637_637 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 650_650 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 653_653 94.0 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 687_687 94.0 962.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 731_731 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 846_846 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 937_937 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 938_938 94.0 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 823_961 94.0 962.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 59_59 94.0 962.0 retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 509_509 94.0 962.0 not_retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 533_533 94.0 962.0 not_retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 603_603 94.0 962.0 not_retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 694_694 94.0 962.0 not_retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 725_725 94.0 962.0 not_retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 771_771 94.0 962.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 835_835 94.0 962.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 74_74 94.0 962.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 176_176 94.0 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 777_779 94.0 962.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 31_34 94.0 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 38_41 94.0 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 44_55 94.0 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 58_64 94.0 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 70_78 94.0 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 81_97 94.0 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 106_113 94.0 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 120_127 94.0 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 134_139 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 142_144 94.0 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 148_167 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 168_170 94.0 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 179_181 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 182_184 94.0 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 190_192 94.0 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 205_208 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 210_220 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 223_225 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 228_231 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 242_257 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 261_264 94.0 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 266_271 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 284_293 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 298_300 94.0 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 304_315 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000409085 Q2M2I8 3 22 339_344 94.0 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 1_961 94.0 864.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 46_315 94.0 864.0 not_retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 52_60 94.0 864.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 823_960 94.0 864.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 12_42 94.0 864.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 397_614 94.0 864.0 not_retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 658_663 94.0 864.0 not_retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 176_176 94.0 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 74_74 94.0 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 1_1 94.0 864.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 14_14 94.0 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 234_234 94.0 864.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 235_235 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 354_354 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 389_389 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 391_391 94.0 864.0 not_retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 441_441 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 606_606 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 618_618 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 620_620 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 623_623 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 624_624 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 637_637 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 650_650 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 653_653 94.0 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 687_687 94.0 864.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 731_731 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 846_846 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 937_937 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 938_938 94.0 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 823_961 94.0 864.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 59_59 94.0 864.0 retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 509_509 94.0 864.0 not_retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 533_533 94.0 864.0 not_retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 603_603 94.0 864.0 not_retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 694_694 94.0 864.0 not_retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 725_725 94.0 864.0 not_retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 771_771 94.0 864.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 835_835 94.0 864.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 74_74 94.0 864.0 retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 176_176 94.0 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 777_779 94.0 864.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 31_34 94.0 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 38_41 94.0 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 44_55 94.0 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 58_64 94.0 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 70_78 94.0 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 81_97 94.0 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 106_113 94.0 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 120_127 94.0 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 134_139 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 142_144 94.0 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 148_167 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 168_170 94.0 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 179_181 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 182_184 94.0 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 190_192 94.0 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 205_208 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 210_220 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 223_225 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 228_231 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 242_257 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 261_264 94.0 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 266_271 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 284_293 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 298_300 94.0 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 304_315 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69783992 - RPIA chr2:89028796 ENST00000406297 Q2M2I8 3 18 339_344 94.0 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 1_961 54.333333333333336 962.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 46_315 54.333333333333336 962.0 not_retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 52_60 54.333333333333336 962.0 not_retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 823_960 54.333333333333336 962.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 12_42 54.333333333333336 962.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 397_614 54.333333333333336 962.0 not_retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 658_663 54.333333333333336 962.0 not_retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 176_176 54.333333333333336 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 74_74 54.333333333333336 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 1_1 54.333333333333336 962.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 14_14 54.333333333333336 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 234_234 54.333333333333336 962.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 235_235 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 354_354 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 389_389 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 391_391 54.333333333333336 962.0 not_retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 441_441 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 606_606 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 618_618 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 620_620 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 623_623 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 624_624 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 637_637 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 650_650 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 653_653 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 687_687 54.333333333333336 962.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 731_731 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 846_846 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 937_937 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 938_938 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 823_961 54.333333333333336 962.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 59_59 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 509_509 54.333333333333336 962.0 not_retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 533_533 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 603_603 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 694_694 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 725_725 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 771_771 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 835_835 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 74_74 54.333333333333336 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 176_176 54.333333333333336 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 777_779 54.333333333333336 962.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 31_34 54.333333333333336 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 38_41 54.333333333333336 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 44_55 54.333333333333336 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 58_64 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 70_78 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 81_97 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 106_113 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 120_127 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 134_139 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 142_144 54.333333333333336 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 148_167 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 168_170 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 179_181 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 182_184 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 190_192 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 205_208 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 210_220 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 223_225 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 228_231 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 242_257 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 261_264 54.333333333333336 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 266_271 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 284_293 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 298_300 54.333333333333336 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 304_315 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000409085 Q2M2I8 2 22 339_344 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 1_961 54.333333333333336 864.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 46_315 54.333333333333336 864.0 not_retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 52_60 54.333333333333336 864.0 not_retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 823_960 54.333333333333336 864.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 12_42 54.333333333333336 864.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 397_614 54.333333333333336 864.0 not_retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 658_663 54.333333333333336 864.0 not_retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 176_176 54.333333333333336 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 74_74 54.333333333333336 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 1_1 54.333333333333336 864.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 14_14 54.333333333333336 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 234_234 54.333333333333336 864.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 235_235 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 354_354 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 389_389 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 391_391 54.333333333333336 864.0 not_retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 441_441 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 606_606 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 618_618 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 620_620 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 623_623 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 624_624 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 637_637 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 650_650 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 653_653 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 687_687 54.333333333333336 864.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 731_731 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 846_846 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 937_937 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 938_938 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 823_961 54.333333333333336 864.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 59_59 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 509_509 54.333333333333336 864.0 not_retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 533_533 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 603_603 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 694_694 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 725_725 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 771_771 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 835_835 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 74_74 54.333333333333336 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 176_176 54.333333333333336 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 777_779 54.333333333333336 864.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 31_34 54.333333333333336 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 38_41 54.333333333333336 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 44_55 54.333333333333336 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 58_64 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 70_78 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 81_97 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 106_113 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 120_127 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 134_139 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 142_144 54.333333333333336 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 148_167 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 168_170 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 179_181 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 182_184 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 190_192 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 205_208 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 210_220 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 223_225 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 228_231 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 242_257 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 261_264 54.333333333333336 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 266_271 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 284_293 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 298_300 54.333333333333336 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 304_315 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - RFWD2 chr1:175996824 ENST00000406297 Q2M2I8 2 18 339_344 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 1_961 54.333333333333336 962.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 46_315 54.333333333333336 962.0 not_retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 52_60 54.333333333333336 962.0 not_retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 823_960 54.333333333333336 962.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 12_42 54.333333333333336 962.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 397_614 54.333333333333336 962.0 not_retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 658_663 54.333333333333336 962.0 not_retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 176_176 54.333333333333336 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 74_74 54.333333333333336 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 1_1 54.333333333333336 962.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 14_14 54.333333333333336 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 234_234 54.333333333333336 962.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 235_235 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 354_354 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 389_389 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 391_391 54.333333333333336 962.0 not_retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 441_441 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 606_606 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 618_618 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 620_620 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 623_623 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 624_624 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 637_637 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 650_650 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 653_653 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 687_687 54.333333333333336 962.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 731_731 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 846_846 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 937_937 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 938_938 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 823_961 54.333333333333336 962.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 59_59 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 509_509 54.333333333333336 962.0 not_retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 533_533 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 603_603 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 694_694 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 725_725 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 771_771 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 835_835 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 74_74 54.333333333333336 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 176_176 54.333333333333336 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 777_779 54.333333333333336 962.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 31_34 54.333333333333336 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 38_41 54.333333333333336 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 44_55 54.333333333333336 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 58_64 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 70_78 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 81_97 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 106_113 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 120_127 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 134_139 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 142_144 54.333333333333336 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 148_167 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 168_170 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 179_181 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 182_184 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 190_192 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 205_208 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 210_220 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 223_225 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 228_231 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 242_257 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 261_264 54.333333333333336 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 266_271 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 284_293 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 298_300 54.333333333333336 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 304_315 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 339_344 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 1_961 54.333333333333336 864.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 46_315 54.333333333333336 864.0 not_retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 52_60 54.333333333333336 864.0 not_retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 823_960 54.333333333333336 864.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 12_42 54.333333333333336 864.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 397_614 54.333333333333336 864.0 not_retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 658_663 54.333333333333336 864.0 not_retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 176_176 54.333333333333336 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 74_74 54.333333333333336 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 1_1 54.333333333333336 864.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 14_14 54.333333333333336 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 234_234 54.333333333333336 864.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 235_235 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 354_354 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 389_389 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 391_391 54.333333333333336 864.0 not_retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 441_441 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 606_606 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 618_618 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 620_620 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 623_623 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 624_624 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 637_637 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 650_650 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 653_653 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 687_687 54.333333333333336 864.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 731_731 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 846_846 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 937_937 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 938_938 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 823_961 54.333333333333336 864.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 59_59 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 509_509 54.333333333333336 864.0 not_retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 533_533 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 603_603 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 694_694 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 725_725 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 771_771 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 835_835 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 74_74 54.333333333333336 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 176_176 54.333333333333336 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 777_779 54.333333333333336 864.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 31_34 54.333333333333336 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 38_41 54.333333333333336 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 44_55 54.333333333333336 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 58_64 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 70_78 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 81_97 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 106_113 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 120_127 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 134_139 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 142_144 54.333333333333336 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 148_167 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 168_170 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 179_181 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 182_184 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 190_192 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 205_208 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 210_220 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 223_225 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 228_231 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 242_257 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 261_264 54.333333333333336 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 266_271 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 284_293 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 298_300 54.333333333333336 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 304_315 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870009 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 339_344 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 1_961 54.333333333333336 962.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 46_315 54.333333333333336 962.0 not_retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 52_60 54.333333333333336 962.0 not_retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 823_960 54.333333333333336 962.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 12_42 54.333333333333336 962.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 397_614 54.333333333333336 962.0 not_retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 658_663 54.333333333333336 962.0 not_retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 176_176 54.333333333333336 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 74_74 54.333333333333336 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 1_1 54.333333333333336 962.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 14_14 54.333333333333336 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 234_234 54.333333333333336 962.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 235_235 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 354_354 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 389_389 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 391_391 54.333333333333336 962.0 not_retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 441_441 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 606_606 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 618_618 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 620_620 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 623_623 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 624_624 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 637_637 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 650_650 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 653_653 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 687_687 54.333333333333336 962.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 731_731 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 846_846 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 937_937 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 938_938 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 823_961 54.333333333333336 962.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 59_59 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 509_509 54.333333333333336 962.0 not_retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 533_533 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 603_603 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 694_694 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 725_725 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 771_771 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 835_835 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 74_74 54.333333333333336 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 176_176 54.333333333333336 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 777_779 54.333333333333336 962.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 31_34 54.333333333333336 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 38_41 54.333333333333336 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 44_55 54.333333333333336 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 58_64 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 70_78 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 81_97 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 106_113 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 120_127 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 134_139 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 142_144 54.333333333333336 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 148_167 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 168_170 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 179_181 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 182_184 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 190_192 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 205_208 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 210_220 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 223_225 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 228_231 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 242_257 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 261_264 54.333333333333336 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 266_271 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 284_293 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 298_300 54.333333333333336 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 304_315 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000409085 Q2M2I8 2 22 339_344 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 1_961 54.333333333333336 864.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 46_315 54.333333333333336 864.0 not_retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 52_60 54.333333333333336 864.0 not_retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 823_960 54.333333333333336 864.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 12_42 54.333333333333336 864.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 397_614 54.333333333333336 864.0 not_retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 658_663 54.333333333333336 864.0 not_retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 176_176 54.333333333333336 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 74_74 54.333333333333336 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 1_1 54.333333333333336 864.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 14_14 54.333333333333336 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 234_234 54.333333333333336 864.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 235_235 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 354_354 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 389_389 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 391_391 54.333333333333336 864.0 not_retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 441_441 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 606_606 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 618_618 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 620_620 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 623_623 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 624_624 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 637_637 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 650_650 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 653_653 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 687_687 54.333333333333336 864.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 731_731 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 846_846 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 937_937 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 938_938 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 823_961 54.333333333333336 864.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 59_59 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 509_509 54.333333333333336 864.0 not_retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 533_533 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 603_603 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 694_694 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 725_725 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 771_771 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 835_835 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 74_74 54.333333333333336 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 176_176 54.333333333333336 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 777_779 54.333333333333336 864.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 31_34 54.333333333333336 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 38_41 54.333333333333336 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 44_55 54.333333333333336 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 58_64 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 70_78 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 81_97 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 106_113 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 120_127 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 134_139 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 142_144 54.333333333333336 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 148_167 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 168_170 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 179_181 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 182_184 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 190_192 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 205_208 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 210_220 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 223_225 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 228_231 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 242_257 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 261_264 54.333333333333336 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 266_271 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 284_293 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 298_300 54.333333333333336 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 304_315 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - KCMF1 chr2:85255012 ENST00000406297 Q2M2I8 2 18 339_344 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 1_961 54.333333333333336 962.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 46_315 54.333333333333336 962.0 not_retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 52_60 54.333333333333336 962.0 not_retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 823_960 54.333333333333336 962.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 12_42 54.333333333333336 962.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 397_614 54.333333333333336 962.0 not_retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 658_663 54.333333333333336 962.0 not_retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 176_176 54.333333333333336 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 74_74 54.333333333333336 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 1_1 54.333333333333336 962.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 14_14 54.333333333333336 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 234_234 54.333333333333336 962.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 235_235 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 354_354 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 389_389 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 391_391 54.333333333333336 962.0 not_retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 441_441 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 606_606 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 618_618 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 620_620 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 623_623 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 624_624 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 637_637 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 650_650 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 653_653 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 687_687 54.333333333333336 962.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 731_731 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 846_846 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 937_937 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 938_938 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 823_961 54.333333333333336 962.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 59_59 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 509_509 54.333333333333336 962.0 not_retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 533_533 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 603_603 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 694_694 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 725_725 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 771_771 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 835_835 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 74_74 54.333333333333336 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 176_176 54.333333333333336 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 777_779 54.333333333333336 962.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 31_34 54.333333333333336 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 38_41 54.333333333333336 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 44_55 54.333333333333336 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 58_64 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 70_78 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 81_97 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 106_113 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 120_127 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 134_139 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 142_144 54.333333333333336 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 148_167 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 168_170 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 179_181 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 182_184 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 190_192 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 205_208 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 210_220 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 223_225 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 228_231 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 242_257 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 261_264 54.333333333333336 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 266_271 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 284_293 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 298_300 54.333333333333336 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 304_315 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000409085 Q2M2I8 2 22 339_344 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 1_961 54.333333333333336 864.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 46_315 54.333333333333336 864.0 not_retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 52_60 54.333333333333336 864.0 not_retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 823_960 54.333333333333336 864.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 12_42 54.333333333333336 864.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 397_614 54.333333333333336 864.0 not_retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 658_663 54.333333333333336 864.0 not_retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 176_176 54.333333333333336 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 74_74 54.333333333333336 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 1_1 54.333333333333336 864.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 14_14 54.333333333333336 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 234_234 54.333333333333336 864.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 235_235 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 354_354 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 389_389 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 391_391 54.333333333333336 864.0 not_retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 441_441 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 606_606 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 618_618 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 620_620 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 623_623 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 624_624 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 637_637 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 650_650 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 653_653 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 687_687 54.333333333333336 864.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 731_731 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 846_846 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 937_937 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 938_938 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 823_961 54.333333333333336 864.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 59_59 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 509_509 54.333333333333336 864.0 not_retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 533_533 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 603_603 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 694_694 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 725_725 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 771_771 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 835_835 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 74_74 54.333333333333336 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 176_176 54.333333333333336 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 777_779 54.333333333333336 864.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 31_34 54.333333333333336 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 38_41 54.333333333333336 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 44_55 54.333333333333336 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 58_64 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 70_78 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 81_97 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 106_113 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 120_127 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 134_139 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 142_144 54.333333333333336 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 148_167 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 168_170 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 179_181 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 182_184 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 190_192 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 205_208 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 210_220 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 223_225 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 228_231 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 242_257 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 261_264 54.333333333333336 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 266_271 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 284_293 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 298_300 54.333333333333336 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 304_315 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - NFU1 chr2:69650849 ENST00000406297 Q2M2I8 2 18 339_344 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 1_961 54.333333333333336 962.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 46_315 54.333333333333336 962.0 not_retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 52_60 54.333333333333336 962.0 not_retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 823_960 54.333333333333336 962.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 12_42 54.333333333333336 962.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 397_614 54.333333333333336 962.0 not_retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 658_663 54.333333333333336 962.0 not_retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 176_176 54.333333333333336 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 74_74 54.333333333333336 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 1_1 54.333333333333336 962.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 14_14 54.333333333333336 962.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 234_234 54.333333333333336 962.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 235_235 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 354_354 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 389_389 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 391_391 54.333333333333336 962.0 not_retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 441_441 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 606_606 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 618_618 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 620_620 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 623_623 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 624_624 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 637_637 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 650_650 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 653_653 54.333333333333336 962.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 687_687 54.333333333333336 962.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 731_731 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 846_846 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 937_937 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 938_938 54.333333333333336 962.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 823_961 54.333333333333336 962.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 59_59 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 509_509 54.333333333333336 962.0 not_retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 533_533 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 603_603 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 694_694 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 725_725 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 771_771 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 835_835 54.333333333333336 962.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 74_74 54.333333333333336 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 176_176 54.333333333333336 962.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 777_779 54.333333333333336 962.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 31_34 54.333333333333336 962.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 38_41 54.333333333333336 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 44_55 54.333333333333336 962.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 58_64 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 70_78 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 81_97 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 106_113 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 120_127 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 134_139 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 142_144 54.333333333333336 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 148_167 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 168_170 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 179_181 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 182_184 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 190_192 54.333333333333336 962.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 205_208 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 210_220 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 223_225 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 228_231 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 242_257 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 261_264 54.333333333333336 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 266_271 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 284_293 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 298_300 54.333333333333336 962.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 304_315 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000409085 Q2M2I8 2 22 339_344 54.333333333333336 962.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 1_961 54.333333333333336 864.0 not_retained Chain ID=PRO_0000250578;Note=AP2-associated protein kinase 1 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 46_315 54.333333333333336 864.0 not_retained Domain Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 52_60 54.333333333333336 864.0 not_retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 823_960 54.333333333333336 864.0 not_retained Region Note=Clathrin-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17494869;Dbxref=PMID:17494869 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 12_42 54.333333333333336 864.0 retained Compositional bias Note=Gly-rich Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 397_614 54.333333333333336 864.0 not_retained Compositional bias Note=Gln-rich Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 658_663 54.333333333333336 864.0 not_retained Compositional bias Note=Poly-Ala Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 176_176 54.333333333333336 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 74_74 54.333333333333336 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 1_1 54.333333333333336 864.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 14_14 54.333333333333336 864.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163;Dbxref=PMID:19369195,PMID:23186163 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 234_234 54.333333333333336 864.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 235_235 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 354_354 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 389_389 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332;Dbxref=PMID:16964243,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 391_391 54.333333333333336 864.0 not_retained Modified residue Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 441_441 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 606_606 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 618_618 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C1X8 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 620_620 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 623_623 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 624_624 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 637_637 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19367720,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:18691976,PMID:19367720,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 650_650 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 653_653 54.333333333333336 864.0 not_retained Modified residue Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 687_687 54.333333333333336 864.0 not_retained Modified residue Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 731_731 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 846_846 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 937_937 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 938_938 54.333333333333336 864.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3UHJ0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 823_961 54.333333333333336 864.0 not_retained Alternative sequence ID=VSP_039459;Note=In isoform 2. EKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL->GKVIISVSSVMHDMCACFKNDKYLVNQSLGNSPATPEAKAI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 59_59 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040348;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34535244,PMID:17344846 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 509_509 54.333333333333336 864.0 not_retained Natural variant ID=VAR_031129;Note=K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10470851,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs6715776,PMID:10470851,PMID:15489334 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 533_533 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040349;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1263928487,PMID:17344846 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 603_603 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040350;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56038532,PMID:17344846 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 694_694 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040351;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55889248,PMID:17344846 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 725_725 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040352;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35285785,PMID:17344846 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 771_771 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040353;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34422616,PMID:17344846 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 835_835 54.333333333333336 864.0 not_retained Natural variant ID=VAR_040354;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 74_74 54.333333333333336 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. Does not interact with monoubiquitinated NOTCH1. K->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124;Dbxref=PMID:12952931,PMID:18657069,PMID:21464124 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 176_176 54.333333333333336 864.0 not_retained Mutagenesis Note=Inhibits autophosphorylation and phosphorylation of AP2M1. Does not affect NUMB localization. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:18657069;Dbxref=PMID:12952931,PMID:18657069 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 777_779 54.333333333333336 864.0 not_retained Mutagenesis Note=Does not affect interaction with NOTCH1 but abolishes interaction with ESP15. DPF->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21464124;Dbxref=PMID:21464124 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 31_34 54.333333333333336 864.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 38_41 54.333333333333336 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 44_55 54.333333333333336 864.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 58_64 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 70_78 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 81_97 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 106_113 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 120_127 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 134_139 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 142_144 54.333333333333336 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 148_167 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 168_170 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 179_181 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 182_184 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 190_192 54.333333333333336 864.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 205_208 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 210_220 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 223_225 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 228_231 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 242_257 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 261_264 54.333333333333336 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4WSQ Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 266_271 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 284_293 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 298_300 54.333333333333336 864.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 304_315 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAK1 chr2:69870010 - YIPF1 chr1:54325826 ENST00000406297 Q2M2I8 2 18 339_344 54.333333333333336 864.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5TE0 Hgene AAMP chr2:219134105 - ANKZF1 chr2:220096650 ENST00000248450 Q13685 2 11 1_434 91.33333333333333 435.0 not_retained Chain ID=PRO_0000050832;Note=Angio-associated migratory cell protein Hgene AAMP chr2:219134105 - ANKZF1 chr2:220096650 ENST00000248450 Q13685 2 11 89_129 91.33333333333333 435.0 not_retained Repeat Note=WD 1 Hgene AAMP chr2:219134105 - ANKZF1 chr2:220096650 ENST00000248450 Q13685 2 11 132_171 91.33333333333333 435.0 not_retained Repeat Note=WD 2 Hgene AAMP chr2:219134105 - ANKZF1 chr2:220096650 ENST00000248450 Q13685 2 11 173_212 91.33333333333333 435.0 not_retained Repeat Note=WD 3 Hgene AAMP chr2:219134105 - ANKZF1 chr2:220096650 ENST00000248450 Q13685 2 11 214_254 91.33333333333333 435.0 not_retained Repeat Note=WD 4 Hgene AAMP chr2:219134105 - ANKZF1 chr2:220096650 ENST00000248450 Q13685 2 11 258_299 91.33333333333333 435.0 not_retained Repeat Note=WD 5 Hgene AAMP chr2:219134105 - ANKZF1 chr2:220096650 ENST00000248450 Q13685 2 11 315_354 91.33333333333333 435.0 not_retained Repeat Note=WD 6 Hgene AAMP chr2:219134105 - ANKZF1 chr2:220096650 ENST00000248450 Q13685 2 11 356_395 91.33333333333333 435.0 not_retained Repeat Note=WD 7 Hgene AAMP chr2:219134105 - ANKZF1 chr2:220096650 ENST00000248450 Q13685 2 11 398_433 91.33333333333333 435.0 not_retained Repeat Note=WD 8 Hgene AAMP chr2:219134105 - ANKZF1 chr2:220096650 ENST00000248450 Q13685 2 11 53_59 91.33333333333333 435.0 retained Compositional bias Note=Poly-Glu Hgene AAMP chr2:219134105 - ANKZF1 chr2:220096650 ENST00000248450 Q13685 2 11 20_20 91.33333333333333 435.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Hgene AAMP chr2:219134105 - ANKZF1 chr2:220096650 ENST00000248450 Q13685 2 11 250_250 91.33333333333333 435.0 not_retained Natural variant ID=VAR_037061;Note=I->V;Dbxref=dbSNP:rs2305835 Hgene AAMP chr2:219134105 - MARCH4 chr2:217124402 ENST00000248450 Q13685 2 11 1_434 91.33333333333333 435.0 not_retained Chain ID=PRO_0000050832;Note=Angio-associated migratory cell protein Hgene AAMP chr2:219134105 - MARCH4 chr2:217124402 ENST00000248450 Q13685 2 11 89_129 91.33333333333333 435.0 not_retained Repeat Note=WD 1 Hgene AAMP chr2:219134105 - MARCH4 chr2:217124402 ENST00000248450 Q13685 2 11 132_171 91.33333333333333 435.0 not_retained Repeat Note=WD 2 Hgene AAMP chr2:219134105 - MARCH4 chr2:217124402 ENST00000248450 Q13685 2 11 173_212 91.33333333333333 435.0 not_retained Repeat Note=WD 3 Hgene AAMP chr2:219134105 - MARCH4 chr2:217124402 ENST00000248450 Q13685 2 11 214_254 91.33333333333333 435.0 not_retained Repeat Note=WD 4 Hgene AAMP chr2:219134105 - MARCH4 chr2:217124402 ENST00000248450 Q13685 2 11 258_299 91.33333333333333 435.0 not_retained Repeat Note=WD 5 Hgene AAMP chr2:219134105 - MARCH4 chr2:217124402 ENST00000248450 Q13685 2 11 315_354 91.33333333333333 435.0 not_retained Repeat Note=WD 6 Hgene AAMP chr2:219134105 - MARCH4 chr2:217124402 ENST00000248450 Q13685 2 11 356_395 91.33333333333333 435.0 not_retained Repeat Note=WD 7 Hgene AAMP chr2:219134105 - MARCH4 chr2:217124402 ENST00000248450 Q13685 2 11 398_433 91.33333333333333 435.0 not_retained Repeat Note=WD 8 Hgene AAMP chr2:219134105 - MARCH4 chr2:217124402 ENST00000248450 Q13685 2 11 53_59 91.33333333333333 435.0 retained Compositional bias Note=Poly-Glu Hgene AAMP chr2:219134105 - MARCH4 chr2:217124402 ENST00000248450 Q13685 2 11 20_20 91.33333333333333 435.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Hgene AAMP chr2:219134105 - MARCH4 chr2:217124402 ENST00000248450 Q13685 2 11 250_250 91.33333333333333 435.0 not_retained Natural variant ID=VAR_037061;Note=I->V;Dbxref=dbSNP:rs2305835 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 1_23 249.66666666666666 986.0 retained Transit peptide Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 24_985 249.66666666666666 986.0 not_retained Chain ID=PRO_0000250725;Note=Alanine--tRNA ligase%2C mitochondrial Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 240_242 249.66666666666666 986.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P49588 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 632_632 249.66666666666666 986.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 636_636 249.66666666666666 986.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 749_749 249.66666666666666 986.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 753_753 249.66666666666666 986.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 110_110 249.66666666666666 986.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P49588 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 128_128 249.66666666666666 986.0 retained Binding site Note=ATP%3B via amide nitrogen and carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P49588 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 210_210 249.66666666666666 986.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P49588 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 242_242 249.66666666666666 986.0 retained Binding site Note=L-alanine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P49588 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 265_265 249.66666666666666 986.0 not_retained Binding site Note=L-alanine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P49588 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 269_269 249.66666666666666 986.0 not_retained Binding site Note=ATP%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P49588 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 50_50 249.66666666666666 986.0 retained Natural variant ID=VAR_071837;Note=In LKENP%3B deleterious only under stress conditions. F->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24808023;Dbxref=dbSNP:rs587777590,PMID:24808023 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 77_77 249.66666666666666 986.0 retained Natural variant ID=VAR_071838;Note=Found in patient with leukoencephalopathy%3B unknown pathological significance. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24808023;Dbxref=dbSNP:rs375949891,PMID:24808023 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 131_131 249.66666666666666 986.0 retained Natural variant ID=VAR_071839;Note=Found in patient with leukoencephalopathy%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24808023;Dbxref=PMID:24808023 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 155_155 249.66666666666666 986.0 retained Natural variant ID=VAR_065956;Note=In COXPD8. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21549344;Dbxref=dbSNP:rs387907061,PMID:21549344 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 199_199 249.66666666666666 986.0 retained Natural variant ID=VAR_071840;Note=Found in patient with leukoencephalopathy%3B unknown pathological significance. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24808023;Dbxref=dbSNP:rs200105202,PMID:24808023 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 339_339 249.66666666666666 986.0 not_retained Natural variant ID=VAR_027609;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10574462,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs324136,PMID:10574462,PMID:15489334 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 405_405 249.66666666666666 986.0 not_retained Natural variant ID=VAR_071841;Note=In LKENP. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24808023;Dbxref=dbSNP:rs587777592,PMID:24808023 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 484_484 249.66666666666666 986.0 not_retained Natural variant ID=VAR_027610;Note=A->D;Dbxref=dbSNP:rs495294 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 592_592 249.66666666666666 986.0 not_retained Natural variant ID=VAR_065957;Note=In COXPD8. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21549344;Dbxref=dbSNP:rs138119149,PMID:21549344 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 730_730 249.66666666666666 986.0 not_retained Natural variant ID=VAR_071842;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24808023;Dbxref=dbSNP:rs35623954,PMID:24808023 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 850_850 249.66666666666666 986.0 not_retained Natural variant ID=VAR_057357;Note=M->V;Dbxref=dbSNP:rs35783144 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 965_965 249.66666666666666 986.0 not_retained Natural variant ID=VAR_071843;Note=In LKENP. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24808023;Dbxref=dbSNP:rs543267101,PMID:24808023 Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 812_832 249.66666666666666 986.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6NLY Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 838_877 249.66666666666666 986.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6NLY Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 883_887 249.66666666666666 986.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6NLQ Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 893_906 249.66666666666666 986.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6NLQ Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 911_917 249.66666666666666 986.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6NLQ Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 919_921 249.66666666666666 986.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6NLQ Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 922_928 249.66666666666666 986.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6NLQ Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 939_949 249.66666666666666 986.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6NLQ Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 953_956 249.66666666666666 986.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6NLQ Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 958_966 249.66666666666666 986.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6NLQ Hgene AARS2 chr6:44278730 - SPATS1 chr6:44328182 ENST00000244571 Q5JTZ9 4 22 970_984 249.66666666666666 986.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6NLQ Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 1_23 249.66666666666666 986.0 retained Transit peptide Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 24_985 249.66666666666666 986.0 not_retained Chain ID=PRO_0000250725;Note=Alanine--tRNA ligase%2C mitochondrial Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 240_242 249.66666666666666 986.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P49588 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 632_632 249.66666666666666 986.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 636_636 249.66666666666666 986.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 749_749 249.66666666666666 986.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 753_753 249.66666666666666 986.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 110_110 249.66666666666666 986.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P49588 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 128_128 249.66666666666666 986.0 retained Binding site Note=ATP%3B via amide nitrogen and carbonyl oxygen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P49588 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 210_210 249.66666666666666 986.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P49588 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 242_242 249.66666666666666 986.0 retained Binding site Note=L-alanine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P49588 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 265_265 249.66666666666666 986.0 not_retained Binding site Note=L-alanine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P49588 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 269_269 249.66666666666666 986.0 not_retained Binding site Note=ATP%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P49588 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 50_50 249.66666666666666 986.0 retained Natural variant ID=VAR_071837;Note=In LKENP%3B deleterious only under stress conditions. F->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24808023;Dbxref=dbSNP:rs587777590,PMID:24808023 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 77_77 249.66666666666666 986.0 retained Natural variant ID=VAR_071838;Note=Found in patient with leukoencephalopathy%3B unknown pathological significance. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24808023;Dbxref=dbSNP:rs375949891,PMID:24808023 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 131_131 249.66666666666666 986.0 retained Natural variant ID=VAR_071839;Note=Found in patient with leukoencephalopathy%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24808023;Dbxref=PMID:24808023 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 155_155 249.66666666666666 986.0 retained Natural variant ID=VAR_065956;Note=In COXPD8. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21549344;Dbxref=dbSNP:rs387907061,PMID:21549344 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 199_199 249.66666666666666 986.0 retained Natural variant ID=VAR_071840;Note=Found in patient with leukoencephalopathy%3B unknown pathological significance. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24808023;Dbxref=dbSNP:rs200105202,PMID:24808023 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 339_339 249.66666666666666 986.0 not_retained Natural variant ID=VAR_027609;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10574462,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs324136,PMID:10574462,PMID:15489334 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 405_405 249.66666666666666 986.0 not_retained Natural variant ID=VAR_071841;Note=In LKENP. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24808023;Dbxref=dbSNP:rs587777592,PMID:24808023 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 484_484 249.66666666666666 986.0 not_retained Natural variant ID=VAR_027610;Note=A->D;Dbxref=dbSNP:rs495294 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 592_592 249.66666666666666 986.0 not_retained Natural variant ID=VAR_065957;Note=In COXPD8. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21549344;Dbxref=dbSNP:rs138119149,PMID:21549344 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 730_730 249.66666666666666 986.0 not_retained Natural variant ID=VAR_071842;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24808023;Dbxref=dbSNP:rs35623954,PMID:24808023 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 850_850 249.66666666666666 986.0 not_retained Natural variant ID=VAR_057357;Note=M->V;Dbxref=dbSNP:rs35783144 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 965_965 249.66666666666666 986.0 not_retained Natural variant ID=VAR_071843;Note=In LKENP. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24808023;Dbxref=dbSNP:rs543267101,PMID:24808023 Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 812_832 249.66666666666666 986.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6NLY Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 838_877 249.66666666666666 986.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6NLY Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 883_887 249.66666666666666 986.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6NLQ Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 893_906 249.66666666666666 986.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6NLQ Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 911_917 249.66666666666666 986.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6NLQ Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 919_921 249.66666666666666 986.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6NLQ Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 922_928 249.66666666666666 986.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6NLQ Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 939_949 249.66666666666666 986.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6NLQ Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 953_956 249.66666666666666 986.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6NLQ Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 958_966 249.66666666666666 986.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6NLQ Hgene AARS2 chr6:44278731 - SPATS1 chr6:44328183 ENST00000244571 Q5JTZ9 4 22 970_984 249.66666666666666 986.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6NLQ Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 1_968 800.0 969.0 not_retained Chain ID=PRO_0000075281;Note=Alanine--tRNA ligase%2C cytoplasmic Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 214_216 800.0 969.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 605_605 800.0 969.0 retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 609_609 800.0 969.0 retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 723_723 800.0 969.0 retained Mutagenesis Note=Decreases editing activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28493438;Dbxref=PMID:28493438 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 727_727 800.0 969.0 retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 77_77 800.0 969.0 retained Binding site Note=ATP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 95_95 800.0 969.0 retained Binding site Note=ATP%3B via amide nitrogen and carbonyl oxygen;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 176_176 800.0 969.0 retained Binding site Note=ATP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 216_216 800.0 969.0 retained Binding site Note=L-alanine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 239_239 800.0 969.0 retained Binding site Note=L-alanine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 243_243 800.0 969.0 retained Binding site Note=ATP%3B via amide nitrogen;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 1_1 800.0 969.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0000255,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000255|HAMAP-Rule:MF_03133,ECO:0000269|Ref.7,ECO:0007744|PubMed:19413330,ECO:0007744|PubMed:22223895,ECO:0007744|PubMed:22814378;Dbxref=PMID:19413330,PMID:22223895,PMID:22814378 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 3_3 800.0 969.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 8_8 800.0 969.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 19_19 800.0 969.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 399_399 800.0 969.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 555_555 800.0 969.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 876_876 800.0 969.0 not_retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 160_160 800.0 969.0 retained Alternative sequence ID=VSP_057201;Note=In isoform 2. G->GTYLYSFVR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 869_869 800.0 969.0 not_retained Alternative sequence ID=VSP_057202;Note=In isoform 2. K->KATQGPGSPPLGLISSL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 71_71 800.0 969.0 retained Natural variant ID=VAR_067084;Note=In CMT2N. N->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22206013;Dbxref=dbSNP:rs387906792,PMID:22206013 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 81_81 800.0 969.0 retained Natural variant ID=VAR_073719;Note=In DEE29%3B hypomorphic allele%3B results in only 2-fold reduction in aminoacylation efficiency. K->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25817015;Dbxref=dbSNP:rs786205157,PMID:25817015 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 275_275 800.0 969.0 retained Natural variant ID=VAR_028204;Note=G->D;Dbxref=dbSNP:rs11537667 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 329_329 800.0 969.0 retained Natural variant ID=VAR_063527;Note=In CMT2N%3B severely reduces enzyme activity. R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20045102,ECO:0000269|PubMed:22009580;Dbxref=dbSNP:rs267606621,PMID:20045102,PMID:22009580 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 608_608 800.0 969.0 retained Natural variant ID=VAR_073293;Note=Found in a patient with distal hereditary motor neuropathy%3B unknown pathological significance. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24627108;Dbxref=PMID:24627108 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 751_751 800.0 969.0 retained Natural variant ID=VAR_073720;Note=In DEE29%3B results in 10-fold reduction in aminoacylation efficiency. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25817015;Dbxref=dbSNP:rs143370729,PMID:25817015 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 913_913 800.0 969.0 not_retained Natural variant ID=VAR_079703;Note=In DEE29%3B decreases protein abundance%3B decreases aminoacylation activity%3B no effect on the editing activity. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28493438;Dbxref=dbSNP:rs369774476,PMID:28493438 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 448_448 800.0 969.0 retained Mutagenesis Note=Decreases misincorporation of Cys instead of Ala. A->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27622773;Dbxref=PMID:27622773 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 723_723 800.0 969.0 retained Mutagenesis Note=Decreases editing activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28493438;Dbxref=PMID:28493438 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 82_82 800.0 969.0 retained Sequence conflict Note=H->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 334_334 800.0 969.0 retained Sequence conflict Note=Y->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 763_763 800.0 969.0 retained Sequence conflict Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 867_867 800.0 969.0 not_retained Sequence conflict Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 7_20 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 34_36 800.0 969.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 45_49 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 50_53 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 62_65 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 68_76 800.0 969.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 78_81 800.0 969.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEO Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 85_87 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 90_93 800.0 969.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 96_109 800.0 969.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 111_123 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 130_132 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 133_138 800.0 969.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 142_144 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 150_158 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 163_165 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 166_169 800.0 969.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 171_174 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 178_195 800.0 969.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 201_203 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 204_207 800.0 969.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 211_224 800.0 969.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 230_243 800.0 969.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 244_251 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 257_259 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 261_263 800.0 969.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 264_274 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 284_286 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 291_310 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 319_339 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 343_345 800.0 969.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 346_349 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 350_357 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 358_360 800.0 969.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 362_365 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 368_383 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 386_399 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 400_402 800.0 969.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 408_416 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 422_431 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 438_450 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 759_782 800.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 789_804 800.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 809_851 800.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 856_861 800.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 868_881 800.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 886_893 800.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 894_897 800.0 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 898_904 800.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 907_912 800.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 916_924 800.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 925_928 800.0 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 929_933 800.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 935_943 800.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 945_947 800.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70288524 - COG4 chr16:70553634 ENST00000261772 P49588 17 21 948_960 800.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 1_968 320.6666666666667 969.0 not_retained Chain ID=PRO_0000075281;Note=Alanine--tRNA ligase%2C cytoplasmic Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 214_216 320.6666666666667 969.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 605_605 320.6666666666667 969.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 609_609 320.6666666666667 969.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 723_723 320.6666666666667 969.0 not_retained Mutagenesis Note=Decreases editing activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28493438;Dbxref=PMID:28493438 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 727_727 320.6666666666667 969.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 77_77 320.6666666666667 969.0 retained Binding site Note=ATP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 95_95 320.6666666666667 969.0 retained Binding site Note=ATP%3B via amide nitrogen and carbonyl oxygen;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 176_176 320.6666666666667 969.0 retained Binding site Note=ATP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 216_216 320.6666666666667 969.0 retained Binding site Note=L-alanine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 239_239 320.6666666666667 969.0 retained Binding site Note=L-alanine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 243_243 320.6666666666667 969.0 retained Binding site Note=ATP%3B via amide nitrogen;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 1_1 320.6666666666667 969.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0000255,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000255|HAMAP-Rule:MF_03133,ECO:0000269|Ref.7,ECO:0007744|PubMed:19413330,ECO:0007744|PubMed:22223895,ECO:0007744|PubMed:22814378;Dbxref=PMID:19413330,PMID:22223895,PMID:22814378 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 3_3 320.6666666666667 969.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 8_8 320.6666666666667 969.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 19_19 320.6666666666667 969.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 399_399 320.6666666666667 969.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 555_555 320.6666666666667 969.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 876_876 320.6666666666667 969.0 not_retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 160_160 320.6666666666667 969.0 retained Alternative sequence ID=VSP_057201;Note=In isoform 2. G->GTYLYSFVR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 869_869 320.6666666666667 969.0 not_retained Alternative sequence ID=VSP_057202;Note=In isoform 2. K->KATQGPGSPPLGLISSL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 71_71 320.6666666666667 969.0 retained Natural variant ID=VAR_067084;Note=In CMT2N. N->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22206013;Dbxref=dbSNP:rs387906792,PMID:22206013 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 81_81 320.6666666666667 969.0 retained Natural variant ID=VAR_073719;Note=In DEE29%3B hypomorphic allele%3B results in only 2-fold reduction in aminoacylation efficiency. K->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25817015;Dbxref=dbSNP:rs786205157,PMID:25817015 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 275_275 320.6666666666667 969.0 retained Natural variant ID=VAR_028204;Note=G->D;Dbxref=dbSNP:rs11537667 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 329_329 320.6666666666667 969.0 not_retained Natural variant ID=VAR_063527;Note=In CMT2N%3B severely reduces enzyme activity. R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20045102,ECO:0000269|PubMed:22009580;Dbxref=dbSNP:rs267606621,PMID:20045102,PMID:22009580 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 608_608 320.6666666666667 969.0 not_retained Natural variant ID=VAR_073293;Note=Found in a patient with distal hereditary motor neuropathy%3B unknown pathological significance. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24627108;Dbxref=PMID:24627108 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 751_751 320.6666666666667 969.0 not_retained Natural variant ID=VAR_073720;Note=In DEE29%3B results in 10-fold reduction in aminoacylation efficiency. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25817015;Dbxref=dbSNP:rs143370729,PMID:25817015 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 913_913 320.6666666666667 969.0 not_retained Natural variant ID=VAR_079703;Note=In DEE29%3B decreases protein abundance%3B decreases aminoacylation activity%3B no effect on the editing activity. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28493438;Dbxref=dbSNP:rs369774476,PMID:28493438 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 448_448 320.6666666666667 969.0 not_retained Mutagenesis Note=Decreases misincorporation of Cys instead of Ala. A->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27622773;Dbxref=PMID:27622773 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 723_723 320.6666666666667 969.0 not_retained Mutagenesis Note=Decreases editing activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28493438;Dbxref=PMID:28493438 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 82_82 320.6666666666667 969.0 retained Sequence conflict Note=H->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 334_334 320.6666666666667 969.0 not_retained Sequence conflict Note=Y->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 763_763 320.6666666666667 969.0 not_retained Sequence conflict Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 867_867 320.6666666666667 969.0 not_retained Sequence conflict Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 7_20 320.6666666666667 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 34_36 320.6666666666667 969.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 45_49 320.6666666666667 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 50_53 320.6666666666667 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 62_65 320.6666666666667 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 68_76 320.6666666666667 969.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 78_81 320.6666666666667 969.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEO Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 85_87 320.6666666666667 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 90_93 320.6666666666667 969.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 96_109 320.6666666666667 969.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 111_123 320.6666666666667 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 130_132 320.6666666666667 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 133_138 320.6666666666667 969.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 142_144 320.6666666666667 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 150_158 320.6666666666667 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 163_165 320.6666666666667 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 166_169 320.6666666666667 969.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 171_174 320.6666666666667 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 178_195 320.6666666666667 969.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 201_203 320.6666666666667 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 204_207 320.6666666666667 969.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 211_224 320.6666666666667 969.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 230_243 320.6666666666667 969.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 244_251 320.6666666666667 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 257_259 320.6666666666667 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 261_263 320.6666666666667 969.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 264_274 320.6666666666667 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 284_286 320.6666666666667 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 291_310 320.6666666666667 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 319_339 320.6666666666667 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 343_345 320.6666666666667 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 346_349 320.6666666666667 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 350_357 320.6666666666667 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 358_360 320.6666666666667 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 362_365 320.6666666666667 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 368_383 320.6666666666667 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 386_399 320.6666666666667 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 400_402 320.6666666666667 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 408_416 320.6666666666667 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 422_431 320.6666666666667 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 438_450 320.6666666666667 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 759_782 320.6666666666667 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 789_804 320.6666666666667 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 809_851 320.6666666666667 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 856_861 320.6666666666667 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 868_881 320.6666666666667 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 886_893 320.6666666666667 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 894_897 320.6666666666667 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 898_904 320.6666666666667 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 907_912 320.6666666666667 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 916_924 320.6666666666667 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 925_928 320.6666666666667 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 929_933 320.6666666666667 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 935_943 320.6666666666667 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 945_947 320.6666666666667 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70303521 - ST3GAL2 chr16:70415765 ENST00000261772 P49588 7 21 948_960 320.6666666666667 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 1_968 48.0 969.0 not_retained Chain ID=PRO_0000075281;Note=Alanine--tRNA ligase%2C cytoplasmic Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 214_216 48.0 969.0 not_retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 605_605 48.0 969.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 609_609 48.0 969.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 723_723 48.0 969.0 not_retained Mutagenesis Note=Decreases editing activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28493438;Dbxref=PMID:28493438 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 727_727 48.0 969.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 77_77 48.0 969.0 not_retained Binding site Note=ATP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 95_95 48.0 969.0 not_retained Binding site Note=ATP%3B via amide nitrogen and carbonyl oxygen;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 176_176 48.0 969.0 not_retained Binding site Note=ATP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 216_216 48.0 969.0 not_retained Binding site Note=L-alanine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 239_239 48.0 969.0 not_retained Binding site Note=L-alanine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 243_243 48.0 969.0 not_retained Binding site Note=ATP%3B via amide nitrogen;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 1_1 48.0 969.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0000255,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000255|HAMAP-Rule:MF_03133,ECO:0000269|Ref.7,ECO:0007744|PubMed:19413330,ECO:0007744|PubMed:22223895,ECO:0007744|PubMed:22814378;Dbxref=PMID:19413330,PMID:22223895,PMID:22814378 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 3_3 48.0 969.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 8_8 48.0 969.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 19_19 48.0 969.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 399_399 48.0 969.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 555_555 48.0 969.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 876_876 48.0 969.0 not_retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 160_160 48.0 969.0 not_retained Alternative sequence ID=VSP_057201;Note=In isoform 2. G->GTYLYSFVR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 869_869 48.0 969.0 not_retained Alternative sequence ID=VSP_057202;Note=In isoform 2. K->KATQGPGSPPLGLISSL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 71_71 48.0 969.0 not_retained Natural variant ID=VAR_067084;Note=In CMT2N. N->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22206013;Dbxref=dbSNP:rs387906792,PMID:22206013 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 81_81 48.0 969.0 not_retained Natural variant ID=VAR_073719;Note=In DEE29%3B hypomorphic allele%3B results in only 2-fold reduction in aminoacylation efficiency. K->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25817015;Dbxref=dbSNP:rs786205157,PMID:25817015 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 275_275 48.0 969.0 not_retained Natural variant ID=VAR_028204;Note=G->D;Dbxref=dbSNP:rs11537667 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 329_329 48.0 969.0 not_retained Natural variant ID=VAR_063527;Note=In CMT2N%3B severely reduces enzyme activity. R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20045102,ECO:0000269|PubMed:22009580;Dbxref=dbSNP:rs267606621,PMID:20045102,PMID:22009580 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 608_608 48.0 969.0 not_retained Natural variant ID=VAR_073293;Note=Found in a patient with distal hereditary motor neuropathy%3B unknown pathological significance. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24627108;Dbxref=PMID:24627108 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 751_751 48.0 969.0 not_retained Natural variant ID=VAR_073720;Note=In DEE29%3B results in 10-fold reduction in aminoacylation efficiency. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25817015;Dbxref=dbSNP:rs143370729,PMID:25817015 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 913_913 48.0 969.0 not_retained Natural variant ID=VAR_079703;Note=In DEE29%3B decreases protein abundance%3B decreases aminoacylation activity%3B no effect on the editing activity. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28493438;Dbxref=dbSNP:rs369774476,PMID:28493438 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 448_448 48.0 969.0 not_retained Mutagenesis Note=Decreases misincorporation of Cys instead of Ala. A->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27622773;Dbxref=PMID:27622773 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 723_723 48.0 969.0 not_retained Mutagenesis Note=Decreases editing activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28493438;Dbxref=PMID:28493438 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 82_82 48.0 969.0 not_retained Sequence conflict Note=H->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 334_334 48.0 969.0 not_retained Sequence conflict Note=Y->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 763_763 48.0 969.0 not_retained Sequence conflict Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 867_867 48.0 969.0 not_retained Sequence conflict Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 7_20 48.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 34_36 48.0 969.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 45_49 48.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 50_53 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 62_65 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 68_76 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 78_81 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEO Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 85_87 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 90_93 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 96_109 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 111_123 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 130_132 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 133_138 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 142_144 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 150_158 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 163_165 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 166_169 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 171_174 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 178_195 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 201_203 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 204_207 48.0 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 211_224 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 230_243 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 244_251 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 257_259 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 261_263 48.0 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 264_274 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 284_286 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 291_310 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 319_339 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 343_345 48.0 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 346_349 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 350_357 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 358_360 48.0 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 362_365 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 368_383 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 386_399 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 400_402 48.0 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 408_416 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 422_431 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 438_450 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 759_782 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 789_804 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 809_851 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 856_861 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 868_881 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 886_893 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 894_897 48.0 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 898_904 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 907_912 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 916_924 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 925_928 48.0 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 929_933 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 935_943 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 945_947 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - CEP192 chr18:13114128 ENST00000261772 P49588 2 21 948_960 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 1_968 48.0 969.0 not_retained Chain ID=PRO_0000075281;Note=Alanine--tRNA ligase%2C cytoplasmic Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 214_216 48.0 969.0 not_retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 605_605 48.0 969.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 609_609 48.0 969.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 723_723 48.0 969.0 not_retained Mutagenesis Note=Decreases editing activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28493438;Dbxref=PMID:28493438 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 727_727 48.0 969.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 77_77 48.0 969.0 not_retained Binding site Note=ATP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 95_95 48.0 969.0 not_retained Binding site Note=ATP%3B via amide nitrogen and carbonyl oxygen;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 176_176 48.0 969.0 not_retained Binding site Note=ATP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 216_216 48.0 969.0 not_retained Binding site Note=L-alanine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 239_239 48.0 969.0 not_retained Binding site Note=L-alanine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 243_243 48.0 969.0 not_retained Binding site Note=ATP%3B via amide nitrogen;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 1_1 48.0 969.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0000255,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000255|HAMAP-Rule:MF_03133,ECO:0000269|Ref.7,ECO:0007744|PubMed:19413330,ECO:0007744|PubMed:22223895,ECO:0007744|PubMed:22814378;Dbxref=PMID:19413330,PMID:22223895,PMID:22814378 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 3_3 48.0 969.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 8_8 48.0 969.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 19_19 48.0 969.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 399_399 48.0 969.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 555_555 48.0 969.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 876_876 48.0 969.0 not_retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 160_160 48.0 969.0 not_retained Alternative sequence ID=VSP_057201;Note=In isoform 2. G->GTYLYSFVR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 869_869 48.0 969.0 not_retained Alternative sequence ID=VSP_057202;Note=In isoform 2. K->KATQGPGSPPLGLISSL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 71_71 48.0 969.0 not_retained Natural variant ID=VAR_067084;Note=In CMT2N. N->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22206013;Dbxref=dbSNP:rs387906792,PMID:22206013 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 81_81 48.0 969.0 not_retained Natural variant ID=VAR_073719;Note=In DEE29%3B hypomorphic allele%3B results in only 2-fold reduction in aminoacylation efficiency. K->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25817015;Dbxref=dbSNP:rs786205157,PMID:25817015 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 275_275 48.0 969.0 not_retained Natural variant ID=VAR_028204;Note=G->D;Dbxref=dbSNP:rs11537667 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 329_329 48.0 969.0 not_retained Natural variant ID=VAR_063527;Note=In CMT2N%3B severely reduces enzyme activity. R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20045102,ECO:0000269|PubMed:22009580;Dbxref=dbSNP:rs267606621,PMID:20045102,PMID:22009580 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 608_608 48.0 969.0 not_retained Natural variant ID=VAR_073293;Note=Found in a patient with distal hereditary motor neuropathy%3B unknown pathological significance. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24627108;Dbxref=PMID:24627108 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 751_751 48.0 969.0 not_retained Natural variant ID=VAR_073720;Note=In DEE29%3B results in 10-fold reduction in aminoacylation efficiency. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25817015;Dbxref=dbSNP:rs143370729,PMID:25817015 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 913_913 48.0 969.0 not_retained Natural variant ID=VAR_079703;Note=In DEE29%3B decreases protein abundance%3B decreases aminoacylation activity%3B no effect on the editing activity. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28493438;Dbxref=dbSNP:rs369774476,PMID:28493438 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 448_448 48.0 969.0 not_retained Mutagenesis Note=Decreases misincorporation of Cys instead of Ala. A->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27622773;Dbxref=PMID:27622773 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 723_723 48.0 969.0 not_retained Mutagenesis Note=Decreases editing activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28493438;Dbxref=PMID:28493438 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 82_82 48.0 969.0 not_retained Sequence conflict Note=H->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 334_334 48.0 969.0 not_retained Sequence conflict Note=Y->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 763_763 48.0 969.0 not_retained Sequence conflict Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 867_867 48.0 969.0 not_retained Sequence conflict Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 7_20 48.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 34_36 48.0 969.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 45_49 48.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 50_53 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 62_65 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 68_76 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 78_81 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEO Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 85_87 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 90_93 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 96_109 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 111_123 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 130_132 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 133_138 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 142_144 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 150_158 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 163_165 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 166_169 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 171_174 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 178_195 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 201_203 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 204_207 48.0 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 211_224 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 230_243 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 244_251 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 257_259 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 261_263 48.0 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 264_274 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 284_286 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 291_310 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 319_339 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 343_345 48.0 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 346_349 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 350_357 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 358_360 48.0 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 362_365 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 368_383 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 386_399 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 400_402 48.0 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 408_416 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 422_431 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 438_450 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 759_782 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 789_804 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 809_851 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 856_861 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 868_881 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 886_893 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 894_897 48.0 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 898_904 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 907_912 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 916_924 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 925_928 48.0 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 929_933 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 935_943 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 945_947 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316522 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 948_960 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 1_968 48.0 969.0 not_retained Chain ID=PRO_0000075281;Note=Alanine--tRNA ligase%2C cytoplasmic Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 214_216 48.0 969.0 not_retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 605_605 48.0 969.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 609_609 48.0 969.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 723_723 48.0 969.0 not_retained Mutagenesis Note=Decreases editing activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28493438;Dbxref=PMID:28493438 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 727_727 48.0 969.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03133 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 77_77 48.0 969.0 not_retained Binding site Note=ATP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 95_95 48.0 969.0 not_retained Binding site Note=ATP%3B via amide nitrogen and carbonyl oxygen;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 176_176 48.0 969.0 not_retained Binding site Note=ATP;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 216_216 48.0 969.0 not_retained Binding site Note=L-alanine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 239_239 48.0 969.0 not_retained Binding site Note=L-alanine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 243_243 48.0 969.0 not_retained Binding site Note=ATP%3B via amide nitrogen;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27622773,ECO:0000269|Ref.22,ECO:0007744|PDB:4XEM,ECO:0007744|PDB:4XEO,ECO:0007744|PDB:5KNN;Dbxref=PMID:27622773 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 1_1 48.0 969.0 retained Modified residue Note=N-acetylmethionine;Ontology_term=ECO:0000255,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000255|HAMAP-Rule:MF_03133,ECO:0000269|Ref.7,ECO:0007744|PubMed:19413330,ECO:0007744|PubMed:22223895,ECO:0007744|PubMed:22814378;Dbxref=PMID:19413330,PMID:22223895,PMID:22814378 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 3_3 48.0 969.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 8_8 48.0 969.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 19_19 48.0 969.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 399_399 48.0 969.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 555_555 48.0 969.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 876_876 48.0 969.0 not_retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 160_160 48.0 969.0 not_retained Alternative sequence ID=VSP_057201;Note=In isoform 2. G->GTYLYSFVR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 869_869 48.0 969.0 not_retained Alternative sequence ID=VSP_057202;Note=In isoform 2. K->KATQGPGSPPLGLISSL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 71_71 48.0 969.0 not_retained Natural variant ID=VAR_067084;Note=In CMT2N. N->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22206013;Dbxref=dbSNP:rs387906792,PMID:22206013 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 81_81 48.0 969.0 not_retained Natural variant ID=VAR_073719;Note=In DEE29%3B hypomorphic allele%3B results in only 2-fold reduction in aminoacylation efficiency. K->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25817015;Dbxref=dbSNP:rs786205157,PMID:25817015 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 275_275 48.0 969.0 not_retained Natural variant ID=VAR_028204;Note=G->D;Dbxref=dbSNP:rs11537667 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 329_329 48.0 969.0 not_retained Natural variant ID=VAR_063527;Note=In CMT2N%3B severely reduces enzyme activity. R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20045102,ECO:0000269|PubMed:22009580;Dbxref=dbSNP:rs267606621,PMID:20045102,PMID:22009580 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 608_608 48.0 969.0 not_retained Natural variant ID=VAR_073293;Note=Found in a patient with distal hereditary motor neuropathy%3B unknown pathological significance. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24627108;Dbxref=PMID:24627108 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 751_751 48.0 969.0 not_retained Natural variant ID=VAR_073720;Note=In DEE29%3B results in 10-fold reduction in aminoacylation efficiency. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25817015;Dbxref=dbSNP:rs143370729,PMID:25817015 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 913_913 48.0 969.0 not_retained Natural variant ID=VAR_079703;Note=In DEE29%3B decreases protein abundance%3B decreases aminoacylation activity%3B no effect on the editing activity. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28493438;Dbxref=dbSNP:rs369774476,PMID:28493438 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 448_448 48.0 969.0 not_retained Mutagenesis Note=Decreases misincorporation of Cys instead of Ala. A->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27622773;Dbxref=PMID:27622773 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 723_723 48.0 969.0 not_retained Mutagenesis Note=Decreases editing activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28493438;Dbxref=PMID:28493438 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 82_82 48.0 969.0 not_retained Sequence conflict Note=H->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 334_334 48.0 969.0 not_retained Sequence conflict Note=Y->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 763_763 48.0 969.0 not_retained Sequence conflict Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 867_867 48.0 969.0 not_retained Sequence conflict Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 7_20 48.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 34_36 48.0 969.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 45_49 48.0 969.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 50_53 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 62_65 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 68_76 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 78_81 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEO Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 85_87 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 90_93 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 96_109 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 111_123 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 130_132 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 133_138 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 142_144 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 150_158 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 163_165 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 166_169 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 171_174 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 178_195 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 201_203 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 204_207 48.0 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 211_224 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 230_243 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 244_251 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 257_259 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 261_263 48.0 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 264_274 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 284_286 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 291_310 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 319_339 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 343_345 48.0 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 346_349 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 350_357 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 358_360 48.0 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 362_365 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 368_383 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:4XEM Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 386_399 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 400_402 48.0 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 408_416 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 422_431 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 438_450 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5KNN Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 759_782 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 789_804 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 809_851 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 856_861 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 868_881 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 886_893 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 894_897 48.0 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 898_904 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 907_912 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 916_924 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 925_928 48.0 969.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 929_933 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 935_943 48.0 969.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 945_947 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARS chr16:70316523 - COG4 chr16:70553634 ENST00000261772 P49588 2 21 948_960 48.0 969.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5T76 Hgene AARSD1 chr17:41108221 - FBXL20 chr17:37499494 ENST00000427569 Q9BTE6 6 12 1_412 221.0 413.0 not_retained Chain ID=PRO_0000277465;Note=Alanyl-tRNA editing protein Aarsd1 Hgene AARSD1 chr17:41108221 - FBXL20 chr17:37499494 ENST00000427569 Q9BTE6 6 12 109_109 221.0 413.0 retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene AARSD1 chr17:41108221 - FBXL20 chr17:37499494 ENST00000427569 Q9BTE6 6 12 113_113 221.0 413.0 retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene AARSD1 chr17:41108221 - FBXL20 chr17:37499494 ENST00000427569 Q9BTE6 6 12 209_209 221.0 413.0 retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene AARSD1 chr17:41108221 - FBXL20 chr17:37499494 ENST00000427569 Q9BTE6 6 12 213_213 221.0 413.0 retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene AARSD1 chr17:41108221 - FBXL20 chr17:37499494 ENST00000427569 Q9BTE6 6 12 174_174 221.0 413.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AARSD1 chr17:41108221 - FBXL20 chr17:37499494 ENST00000427569 Q9BTE6 6 12 1_13 221.0 413.0 retained Alternative sequence ID=VSP_043142;Note=In isoform 3. MAFWCQRDSYARE->MFSLPLNCSPDHIRRGSCWGRPQDLKIAAPAWNSKCHPGAGAAMARQHARTLWYDRPRYVFMEFCVEDSTDVHVLIEDHRIVFSCKNADGVELYNEIEFYAKVNSKDSQDKRSSRSITCFVRKWKEKVAWPRLTKEDIKPVWLSVDFDNWRDWEGDEEMELAHVEHYAELLKKVSTKRPPPAMDDLD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Hgene AARSD1 chr17:41108221 - FBXL20 chr17:37499494 ENST00000427569 Q9BTE6 6 12 1_13 221.0 413.0 retained Alternative sequence ID=VSP_043142;Note=In isoform 3. MAFWCQRDSYARE->MFSLPLNCSPDHIRRGSCWGRPQDLKIAAPAWNSKCHPGAGAAMARQHARTLWYDRPRYVFMEFCVEDSTDVHVLIEDHRIVFSCKNADGVELYNEIEFYAKVNSKDSQDKRSSRSITCFVRKWKEKVAWPRLTKEDIKPVWLSVDFDNWRDWEGDEEMELAHVEHYAELLKKVSTKRPPPAMDDLD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Hgene AARSD1 chr17:41113208 - CCR7 chr17:38715194 ENST00000427569 Q9BTE6 3 12 1_412 110.33333333333333 413.0 not_retained Chain ID=PRO_0000277465;Note=Alanyl-tRNA editing protein Aarsd1 Hgene AARSD1 chr17:41113208 - CCR7 chr17:38715194 ENST00000427569 Q9BTE6 3 12 109_109 110.33333333333333 413.0 retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene AARSD1 chr17:41113208 - CCR7 chr17:38715194 ENST00000427569 Q9BTE6 3 12 113_113 110.33333333333333 413.0 retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene AARSD1 chr17:41113208 - CCR7 chr17:38715194 ENST00000427569 Q9BTE6 3 12 209_209 110.33333333333333 413.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene AARSD1 chr17:41113208 - CCR7 chr17:38715194 ENST00000427569 Q9BTE6 3 12 213_213 110.33333333333333 413.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene AARSD1 chr17:41113208 - CCR7 chr17:38715194 ENST00000427569 Q9BTE6 3 12 174_174 110.33333333333333 413.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AARSD1 chr17:41113208 - CCR7 chr17:38715194 ENST00000427569 Q9BTE6 3 12 1_13 110.33333333333333 413.0 retained Alternative sequence ID=VSP_043142;Note=In isoform 3. MAFWCQRDSYARE->MFSLPLNCSPDHIRRGSCWGRPQDLKIAAPAWNSKCHPGAGAAMARQHARTLWYDRPRYVFMEFCVEDSTDVHVLIEDHRIVFSCKNADGVELYNEIEFYAKVNSKDSQDKRSSRSITCFVRKWKEKVAWPRLTKEDIKPVWLSVDFDNWRDWEGDEEMELAHVEHYAELLKKVSTKRPPPAMDDLD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Hgene AARSD1 chr17:41113208 - CCR7 chr17:38715194 ENST00000427569 Q9BTE6 3 12 1_13 110.33333333333333 413.0 retained Alternative sequence ID=VSP_043142;Note=In isoform 3. MAFWCQRDSYARE->MFSLPLNCSPDHIRRGSCWGRPQDLKIAAPAWNSKCHPGAGAAMARQHARTLWYDRPRYVFMEFCVEDSTDVHVLIEDHRIVFSCKNADGVELYNEIEFYAKVNSKDSQDKRSSRSITCFVRKWKEKVAWPRLTKEDIKPVWLSVDFDNWRDWEGDEEMELAHVEHYAELLKKVSTKRPPPAMDDLD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Hgene AARSD1 chr17:41113209 - CCR7 chr17:38715194 ENST00000427569 Q9BTE6 3 12 1_412 110.33333333333333 413.0 not_retained Chain ID=PRO_0000277465;Note=Alanyl-tRNA editing protein Aarsd1 Hgene AARSD1 chr17:41113209 - CCR7 chr17:38715194 ENST00000427569 Q9BTE6 3 12 109_109 110.33333333333333 413.0 retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene AARSD1 chr17:41113209 - CCR7 chr17:38715194 ENST00000427569 Q9BTE6 3 12 113_113 110.33333333333333 413.0 retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene AARSD1 chr17:41113209 - CCR7 chr17:38715194 ENST00000427569 Q9BTE6 3 12 209_209 110.33333333333333 413.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene AARSD1 chr17:41113209 - CCR7 chr17:38715194 ENST00000427569 Q9BTE6 3 12 213_213 110.33333333333333 413.0 not_retained Metal binding Note=Zinc;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene AARSD1 chr17:41113209 - CCR7 chr17:38715194 ENST00000427569 Q9BTE6 3 12 174_174 110.33333333333333 413.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AARSD1 chr17:41113209 - CCR7 chr17:38715194 ENST00000427569 Q9BTE6 3 12 1_13 110.33333333333333 413.0 retained Alternative sequence ID=VSP_043142;Note=In isoform 3. MAFWCQRDSYARE->MFSLPLNCSPDHIRRGSCWGRPQDLKIAAPAWNSKCHPGAGAAMARQHARTLWYDRPRYVFMEFCVEDSTDVHVLIEDHRIVFSCKNADGVELYNEIEFYAKVNSKDSQDKRSSRSITCFVRKWKEKVAWPRLTKEDIKPVWLSVDFDNWRDWEGDEEMELAHVEHYAELLKKVSTKRPPPAMDDLD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Hgene AARSD1 chr17:41113209 - CCR7 chr17:38715194 ENST00000427569 Q9BTE6 3 12 1_13 110.33333333333333 413.0 retained Alternative sequence ID=VSP_043142;Note=In isoform 3. MAFWCQRDSYARE->MFSLPLNCSPDHIRRGSCWGRPQDLKIAAPAWNSKCHPGAGAAMARQHARTLWYDRPRYVFMEFCVEDSTDVHVLIEDHRIVFSCKNADGVELYNEIEFYAKVNSKDSQDKRSSRSITCFVRKWKEKVAWPRLTKEDIKPVWLSVDFDNWRDWEGDEEMELAHVEHYAELLKKVSTKRPPPAMDDLD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 1_1098 464.0 999.0 not_retained Chain ID=PRO_0000315803;Note=Beta-alanine-activating enzyme Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 553_630 464.0 999.0 not_retained Domain Note=Carrier;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 198_206 464.0 999.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 428_428 464.0 999.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 442_442 464.0 999.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 527_527 464.0 999.0 not_retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 589_589 464.0 999.0 not_retained Modified residue Note=O-(pantetheine 4'-phosphoryl)serine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 649_649 464.0 999.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 724_724 464.0 999.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 1_100 464.0 999.0 retained Alternative sequence ID=VSP_030707;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 831_857 464.0 999.0 not_retained Alternative sequence ID=VSP_030710;Note=In isoform 4. CYNGLVYVLKSNSGEKYWMFTTEDAVK->LAVLYQWTNLFIPVYLTIRAKNIFWFP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 831_841 464.0 999.0 not_retained Alternative sequence ID=VSP_030711;Note=In isoform 3. CYNGLVYVLKS->KFLNLRFVELN;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 842_1098 464.0 999.0 not_retained Alternative sequence ID=VSP_030712;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 858_1098 464.0 999.0 not_retained Alternative sequence ID=VSP_030713;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 61_61 464.0 999.0 retained Natural variant ID=VAR_061008;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34543011,PMID:11042152 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 93_93 464.0 999.0 retained Natural variant ID=VAR_061009;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34228795,PMID:11042152 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 368_368 464.0 999.0 retained Natural variant ID=VAR_038309;Note=K->R;Dbxref=dbSNP:rs3796543 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 747_747 464.0 999.0 not_retained Natural variant ID=VAR_038310;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs3796544,PMID:15489334 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 774_774 464.0 999.0 not_retained Natural variant ID=VAR_038311;Note=V->I;Dbxref=dbSNP:rs3796545 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 865_865 464.0 999.0 not_retained Natural variant ID=VAR_038312;Note=T->A;Dbxref=dbSNP:rs12498340 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 1030_1030 464.0 999.0 not_retained Natural variant ID=VAR_038313;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15865210;Dbxref=dbSNP:rs8340,PMID:15865210 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 167_167 464.0 999.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 167_167 464.0 999.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 309_309 464.0 999.0 retained Sequence conflict Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 428_428 464.0 999.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 428_428 464.0 999.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 470_470 464.0 999.0 not_retained Sequence conflict Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 489_489 464.0 999.0 not_retained Sequence conflict Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 498_498 464.0 999.0 not_retained Sequence conflict Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 1_1098 564.0 1099.0 not_retained Chain ID=PRO_0000315803;Note=Beta-alanine-activating enzyme Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 553_630 564.0 1099.0 not_retained Domain Note=Carrier;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 198_206 564.0 1099.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 428_428 564.0 1099.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 442_442 564.0 1099.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 527_527 564.0 1099.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 589_589 564.0 1099.0 not_retained Modified residue Note=O-(pantetheine 4'-phosphoryl)serine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 649_649 564.0 1099.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 724_724 564.0 1099.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 1_100 564.0 1099.0 retained Alternative sequence ID=VSP_030707;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 831_857 564.0 1099.0 not_retained Alternative sequence ID=VSP_030710;Note=In isoform 4. CYNGLVYVLKSNSGEKYWMFTTEDAVK->LAVLYQWTNLFIPVYLTIRAKNIFWFP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 831_841 564.0 1099.0 not_retained Alternative sequence ID=VSP_030711;Note=In isoform 3. CYNGLVYVLKS->KFLNLRFVELN;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 842_1098 564.0 1099.0 not_retained Alternative sequence ID=VSP_030712;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 858_1098 564.0 1099.0 not_retained Alternative sequence ID=VSP_030713;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 61_61 564.0 1099.0 retained Natural variant ID=VAR_061008;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34543011,PMID:11042152 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 93_93 564.0 1099.0 retained Natural variant ID=VAR_061009;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34228795,PMID:11042152 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 368_368 564.0 1099.0 retained Natural variant ID=VAR_038309;Note=K->R;Dbxref=dbSNP:rs3796543 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 747_747 564.0 1099.0 not_retained Natural variant ID=VAR_038310;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs3796544,PMID:15489334 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 774_774 564.0 1099.0 not_retained Natural variant ID=VAR_038311;Note=V->I;Dbxref=dbSNP:rs3796545 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 865_865 564.0 1099.0 not_retained Natural variant ID=VAR_038312;Note=T->A;Dbxref=dbSNP:rs12498340 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 1030_1030 564.0 1099.0 not_retained Natural variant ID=VAR_038313;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15865210;Dbxref=dbSNP:rs8340,PMID:15865210 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 167_167 564.0 1099.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 167_167 564.0 1099.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 309_309 564.0 1099.0 retained Sequence conflict Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 428_428 564.0 1099.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 428_428 564.0 1099.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 470_470 564.0 1099.0 retained Sequence conflict Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 489_489 564.0 1099.0 retained Sequence conflict Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 498_498 564.0 1099.0 retained Sequence conflict Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 1_1098 564.0 858.0 not_retained Chain ID=PRO_0000315803;Note=Beta-alanine-activating enzyme Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 553_630 564.0 858.0 not_retained Domain Note=Carrier;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 198_206 564.0 858.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 428_428 564.0 858.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 442_442 564.0 858.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 527_527 564.0 858.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 589_589 564.0 858.0 not_retained Modified residue Note=O-(pantetheine 4'-phosphoryl)serine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 649_649 564.0 858.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 724_724 564.0 858.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 1_100 564.0 858.0 retained Alternative sequence ID=VSP_030707;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 831_857 564.0 858.0 not_retained Alternative sequence ID=VSP_030710;Note=In isoform 4. CYNGLVYVLKSNSGEKYWMFTTEDAVK->LAVLYQWTNLFIPVYLTIRAKNIFWFP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 831_841 564.0 858.0 not_retained Alternative sequence ID=VSP_030711;Note=In isoform 3. CYNGLVYVLKS->KFLNLRFVELN;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 842_1098 564.0 858.0 not_retained Alternative sequence ID=VSP_030712;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 858_1098 564.0 858.0 not_retained Alternative sequence ID=VSP_030713;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 61_61 564.0 858.0 retained Natural variant ID=VAR_061008;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34543011,PMID:11042152 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 93_93 564.0 858.0 retained Natural variant ID=VAR_061009;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34228795,PMID:11042152 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 368_368 564.0 858.0 retained Natural variant ID=VAR_038309;Note=K->R;Dbxref=dbSNP:rs3796543 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 747_747 564.0 858.0 not_retained Natural variant ID=VAR_038310;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs3796544,PMID:15489334 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 774_774 564.0 858.0 not_retained Natural variant ID=VAR_038311;Note=V->I;Dbxref=dbSNP:rs3796545 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 865_865 564.0 858.0 not_retained Natural variant ID=VAR_038312;Note=T->A;Dbxref=dbSNP:rs12498340 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 1030_1030 564.0 858.0 not_retained Natural variant ID=VAR_038313;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15865210;Dbxref=dbSNP:rs8340,PMID:15865210 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 167_167 564.0 858.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 167_167 564.0 858.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 309_309 564.0 858.0 retained Sequence conflict Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 428_428 564.0 858.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 428_428 564.0 858.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 470_470 564.0 858.0 retained Sequence conflict Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 489_489 564.0 858.0 retained Sequence conflict Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 498_498 564.0 858.0 retained Sequence conflict Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 1_1098 564.0 842.0 not_retained Chain ID=PRO_0000315803;Note=Beta-alanine-activating enzyme Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 553_630 564.0 842.0 not_retained Domain Note=Carrier;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 198_206 564.0 842.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 428_428 564.0 842.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 442_442 564.0 842.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 527_527 564.0 842.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 589_589 564.0 842.0 not_retained Modified residue Note=O-(pantetheine 4'-phosphoryl)serine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 649_649 564.0 842.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 724_724 564.0 842.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 1_100 564.0 842.0 retained Alternative sequence ID=VSP_030707;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 831_857 564.0 842.0 not_retained Alternative sequence ID=VSP_030710;Note=In isoform 4. CYNGLVYVLKSNSGEKYWMFTTEDAVK->LAVLYQWTNLFIPVYLTIRAKNIFWFP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 831_841 564.0 842.0 not_retained Alternative sequence ID=VSP_030711;Note=In isoform 3. CYNGLVYVLKS->KFLNLRFVELN;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 842_1098 564.0 842.0 not_retained Alternative sequence ID=VSP_030712;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 858_1098 564.0 842.0 not_retained Alternative sequence ID=VSP_030713;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 61_61 564.0 842.0 retained Natural variant ID=VAR_061008;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34543011,PMID:11042152 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 93_93 564.0 842.0 retained Natural variant ID=VAR_061009;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34228795,PMID:11042152 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 368_368 564.0 842.0 retained Natural variant ID=VAR_038309;Note=K->R;Dbxref=dbSNP:rs3796543 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 747_747 564.0 842.0 not_retained Natural variant ID=VAR_038310;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs3796544,PMID:15489334 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 774_774 564.0 842.0 not_retained Natural variant ID=VAR_038311;Note=V->I;Dbxref=dbSNP:rs3796545 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 865_865 564.0 842.0 not_retained Natural variant ID=VAR_038312;Note=T->A;Dbxref=dbSNP:rs12498340 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 1030_1030 564.0 842.0 not_retained Natural variant ID=VAR_038313;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15865210;Dbxref=dbSNP:rs8340,PMID:15865210 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 167_167 564.0 842.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 167_167 564.0 842.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 309_309 564.0 842.0 retained Sequence conflict Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 428_428 564.0 842.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 428_428 564.0 842.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 470_470 564.0 842.0 retained Sequence conflict Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 489_489 564.0 842.0 retained Sequence conflict Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217507 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 498_498 564.0 842.0 retained Sequence conflict Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 1_1098 464.0 999.0 not_retained Chain ID=PRO_0000315803;Note=Beta-alanine-activating enzyme Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 553_630 464.0 999.0 not_retained Domain Note=Carrier;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 198_206 464.0 999.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 428_428 464.0 999.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 442_442 464.0 999.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 527_527 464.0 999.0 not_retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 589_589 464.0 999.0 not_retained Modified residue Note=O-(pantetheine 4'-phosphoryl)serine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 649_649 464.0 999.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 724_724 464.0 999.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 1_100 464.0 999.0 retained Alternative sequence ID=VSP_030707;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 831_857 464.0 999.0 not_retained Alternative sequence ID=VSP_030710;Note=In isoform 4. CYNGLVYVLKSNSGEKYWMFTTEDAVK->LAVLYQWTNLFIPVYLTIRAKNIFWFP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 831_841 464.0 999.0 not_retained Alternative sequence ID=VSP_030711;Note=In isoform 3. CYNGLVYVLKS->KFLNLRFVELN;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 842_1098 464.0 999.0 not_retained Alternative sequence ID=VSP_030712;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 858_1098 464.0 999.0 not_retained Alternative sequence ID=VSP_030713;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 61_61 464.0 999.0 retained Natural variant ID=VAR_061008;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34543011,PMID:11042152 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 93_93 464.0 999.0 retained Natural variant ID=VAR_061009;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34228795,PMID:11042152 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 368_368 464.0 999.0 retained Natural variant ID=VAR_038309;Note=K->R;Dbxref=dbSNP:rs3796543 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 747_747 464.0 999.0 not_retained Natural variant ID=VAR_038310;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs3796544,PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 774_774 464.0 999.0 not_retained Natural variant ID=VAR_038311;Note=V->I;Dbxref=dbSNP:rs3796545 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 865_865 464.0 999.0 not_retained Natural variant ID=VAR_038312;Note=T->A;Dbxref=dbSNP:rs12498340 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 1030_1030 464.0 999.0 not_retained Natural variant ID=VAR_038313;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15865210;Dbxref=dbSNP:rs8340,PMID:15865210 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 167_167 464.0 999.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 167_167 464.0 999.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 309_309 464.0 999.0 retained Sequence conflict Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 428_428 464.0 999.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 428_428 464.0 999.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 470_470 464.0 999.0 not_retained Sequence conflict Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 489_489 464.0 999.0 not_retained Sequence conflict Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000513376 Q4L235 9 14 498_498 464.0 999.0 not_retained Sequence conflict Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 1_1098 564.0 1099.0 not_retained Chain ID=PRO_0000315803;Note=Beta-alanine-activating enzyme Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 553_630 564.0 1099.0 not_retained Domain Note=Carrier;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 198_206 564.0 1099.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 428_428 564.0 1099.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 442_442 564.0 1099.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 527_527 564.0 1099.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 589_589 564.0 1099.0 not_retained Modified residue Note=O-(pantetheine 4'-phosphoryl)serine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 649_649 564.0 1099.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 724_724 564.0 1099.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 1_100 564.0 1099.0 retained Alternative sequence ID=VSP_030707;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 831_857 564.0 1099.0 not_retained Alternative sequence ID=VSP_030710;Note=In isoform 4. CYNGLVYVLKSNSGEKYWMFTTEDAVK->LAVLYQWTNLFIPVYLTIRAKNIFWFP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 831_841 564.0 1099.0 not_retained Alternative sequence ID=VSP_030711;Note=In isoform 3. CYNGLVYVLKS->KFLNLRFVELN;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 842_1098 564.0 1099.0 not_retained Alternative sequence ID=VSP_030712;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 858_1098 564.0 1099.0 not_retained Alternative sequence ID=VSP_030713;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 61_61 564.0 1099.0 retained Natural variant ID=VAR_061008;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34543011,PMID:11042152 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 93_93 564.0 1099.0 retained Natural variant ID=VAR_061009;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34228795,PMID:11042152 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 368_368 564.0 1099.0 retained Natural variant ID=VAR_038309;Note=K->R;Dbxref=dbSNP:rs3796543 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 747_747 564.0 1099.0 not_retained Natural variant ID=VAR_038310;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs3796544,PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 774_774 564.0 1099.0 not_retained Natural variant ID=VAR_038311;Note=V->I;Dbxref=dbSNP:rs3796545 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 865_865 564.0 1099.0 not_retained Natural variant ID=VAR_038312;Note=T->A;Dbxref=dbSNP:rs12498340 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 1030_1030 564.0 1099.0 not_retained Natural variant ID=VAR_038313;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15865210;Dbxref=dbSNP:rs8340,PMID:15865210 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 167_167 564.0 1099.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 167_167 564.0 1099.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 309_309 564.0 1099.0 retained Sequence conflict Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 428_428 564.0 1099.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 428_428 564.0 1099.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 470_470 564.0 1099.0 retained Sequence conflict Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 489_489 564.0 1099.0 retained Sequence conflict Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000205214 Q4L235 10 15 498_498 564.0 1099.0 retained Sequence conflict Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 1_1098 564.0 858.0 not_retained Chain ID=PRO_0000315803;Note=Beta-alanine-activating enzyme Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 553_630 564.0 858.0 not_retained Domain Note=Carrier;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 198_206 564.0 858.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 428_428 564.0 858.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 442_442 564.0 858.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 527_527 564.0 858.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 589_589 564.0 858.0 not_retained Modified residue Note=O-(pantetheine 4'-phosphoryl)serine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 649_649 564.0 858.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 724_724 564.0 858.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 1_100 564.0 858.0 retained Alternative sequence ID=VSP_030707;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 831_857 564.0 858.0 not_retained Alternative sequence ID=VSP_030710;Note=In isoform 4. CYNGLVYVLKSNSGEKYWMFTTEDAVK->LAVLYQWTNLFIPVYLTIRAKNIFWFP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 831_841 564.0 858.0 not_retained Alternative sequence ID=VSP_030711;Note=In isoform 3. CYNGLVYVLKS->KFLNLRFVELN;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 842_1098 564.0 858.0 not_retained Alternative sequence ID=VSP_030712;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 858_1098 564.0 858.0 not_retained Alternative sequence ID=VSP_030713;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 61_61 564.0 858.0 retained Natural variant ID=VAR_061008;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34543011,PMID:11042152 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 93_93 564.0 858.0 retained Natural variant ID=VAR_061009;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34228795,PMID:11042152 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 368_368 564.0 858.0 retained Natural variant ID=VAR_038309;Note=K->R;Dbxref=dbSNP:rs3796543 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 747_747 564.0 858.0 not_retained Natural variant ID=VAR_038310;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs3796544,PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 774_774 564.0 858.0 not_retained Natural variant ID=VAR_038311;Note=V->I;Dbxref=dbSNP:rs3796545 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 865_865 564.0 858.0 not_retained Natural variant ID=VAR_038312;Note=T->A;Dbxref=dbSNP:rs12498340 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 1030_1030 564.0 858.0 not_retained Natural variant ID=VAR_038313;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15865210;Dbxref=dbSNP:rs8340,PMID:15865210 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 167_167 564.0 858.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 167_167 564.0 858.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 309_309 564.0 858.0 retained Sequence conflict Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 428_428 564.0 858.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 428_428 564.0 858.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 470_470 564.0 858.0 retained Sequence conflict Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 489_489 564.0 858.0 retained Sequence conflict Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000451613 Q4L235 10 12 498_498 564.0 858.0 retained Sequence conflict Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 1_1098 564.0 842.0 not_retained Chain ID=PRO_0000315803;Note=Beta-alanine-activating enzyme Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 553_630 564.0 842.0 not_retained Domain Note=Carrier;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 198_206 564.0 842.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 428_428 564.0 842.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 442_442 564.0 842.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 527_527 564.0 842.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 589_589 564.0 842.0 not_retained Modified residue Note=O-(pantetheine 4'-phosphoryl)serine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 649_649 564.0 842.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 724_724 564.0 842.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 1_100 564.0 842.0 retained Alternative sequence ID=VSP_030707;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 831_857 564.0 842.0 not_retained Alternative sequence ID=VSP_030710;Note=In isoform 4. CYNGLVYVLKSNSGEKYWMFTTEDAVK->LAVLYQWTNLFIPVYLTIRAKNIFWFP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 831_841 564.0 842.0 not_retained Alternative sequence ID=VSP_030711;Note=In isoform 3. CYNGLVYVLKS->KFLNLRFVELN;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 842_1098 564.0 842.0 not_retained Alternative sequence ID=VSP_030712;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 858_1098 564.0 842.0 not_retained Alternative sequence ID=VSP_030713;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 61_61 564.0 842.0 retained Natural variant ID=VAR_061008;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34543011,PMID:11042152 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 93_93 564.0 842.0 retained Natural variant ID=VAR_061009;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34228795,PMID:11042152 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 368_368 564.0 842.0 retained Natural variant ID=VAR_038309;Note=K->R;Dbxref=dbSNP:rs3796543 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 747_747 564.0 842.0 not_retained Natural variant ID=VAR_038310;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs3796544,PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 774_774 564.0 842.0 not_retained Natural variant ID=VAR_038311;Note=V->I;Dbxref=dbSNP:rs3796545 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 865_865 564.0 842.0 not_retained Natural variant ID=VAR_038312;Note=T->A;Dbxref=dbSNP:rs12498340 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 1030_1030 564.0 842.0 not_retained Natural variant ID=VAR_038313;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15865210;Dbxref=dbSNP:rs8340,PMID:15865210 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 167_167 564.0 842.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 167_167 564.0 842.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 309_309 564.0 842.0 retained Sequence conflict Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 428_428 564.0 842.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 428_428 564.0 842.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 470_470 564.0 842.0 retained Sequence conflict Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 489_489 564.0 842.0 retained Sequence conflict Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52864103 ENST00000502617 Q4L235 10 11 498_498 564.0 842.0 retained Sequence conflict Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 1_1098 464.0 999.0 not_retained Chain ID=PRO_0000315803;Note=Beta-alanine-activating enzyme Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 553_630 464.0 999.0 not_retained Domain Note=Carrier;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 198_206 464.0 999.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 428_428 464.0 999.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 442_442 464.0 999.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 527_527 464.0 999.0 not_retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 589_589 464.0 999.0 not_retained Modified residue Note=O-(pantetheine 4'-phosphoryl)serine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 649_649 464.0 999.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 724_724 464.0 999.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 1_100 464.0 999.0 retained Alternative sequence ID=VSP_030707;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 831_857 464.0 999.0 not_retained Alternative sequence ID=VSP_030710;Note=In isoform 4. CYNGLVYVLKSNSGEKYWMFTTEDAVK->LAVLYQWTNLFIPVYLTIRAKNIFWFP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 831_841 464.0 999.0 not_retained Alternative sequence ID=VSP_030711;Note=In isoform 3. CYNGLVYVLKS->KFLNLRFVELN;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 842_1098 464.0 999.0 not_retained Alternative sequence ID=VSP_030712;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 858_1098 464.0 999.0 not_retained Alternative sequence ID=VSP_030713;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 61_61 464.0 999.0 retained Natural variant ID=VAR_061008;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34543011,PMID:11042152 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 93_93 464.0 999.0 retained Natural variant ID=VAR_061009;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34228795,PMID:11042152 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 368_368 464.0 999.0 retained Natural variant ID=VAR_038309;Note=K->R;Dbxref=dbSNP:rs3796543 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 747_747 464.0 999.0 not_retained Natural variant ID=VAR_038310;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs3796544,PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 774_774 464.0 999.0 not_retained Natural variant ID=VAR_038311;Note=V->I;Dbxref=dbSNP:rs3796545 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 865_865 464.0 999.0 not_retained Natural variant ID=VAR_038312;Note=T->A;Dbxref=dbSNP:rs12498340 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 1030_1030 464.0 999.0 not_retained Natural variant ID=VAR_038313;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15865210;Dbxref=dbSNP:rs8340,PMID:15865210 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 167_167 464.0 999.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 167_167 464.0 999.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 309_309 464.0 999.0 retained Sequence conflict Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 428_428 464.0 999.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 428_428 464.0 999.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 470_470 464.0 999.0 not_retained Sequence conflict Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 489_489 464.0 999.0 not_retained Sequence conflict Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000513376 Q4L235 9 14 498_498 464.0 999.0 not_retained Sequence conflict Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 1_1098 564.0 1099.0 not_retained Chain ID=PRO_0000315803;Note=Beta-alanine-activating enzyme Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 553_630 564.0 1099.0 not_retained Domain Note=Carrier;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 198_206 564.0 1099.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 428_428 564.0 1099.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 442_442 564.0 1099.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 527_527 564.0 1099.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 589_589 564.0 1099.0 not_retained Modified residue Note=O-(pantetheine 4'-phosphoryl)serine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 649_649 564.0 1099.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 724_724 564.0 1099.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 1_100 564.0 1099.0 retained Alternative sequence ID=VSP_030707;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 831_857 564.0 1099.0 not_retained Alternative sequence ID=VSP_030710;Note=In isoform 4. CYNGLVYVLKSNSGEKYWMFTTEDAVK->LAVLYQWTNLFIPVYLTIRAKNIFWFP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 831_841 564.0 1099.0 not_retained Alternative sequence ID=VSP_030711;Note=In isoform 3. CYNGLVYVLKS->KFLNLRFVELN;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 842_1098 564.0 1099.0 not_retained Alternative sequence ID=VSP_030712;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 858_1098 564.0 1099.0 not_retained Alternative sequence ID=VSP_030713;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 61_61 564.0 1099.0 retained Natural variant ID=VAR_061008;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34543011,PMID:11042152 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 93_93 564.0 1099.0 retained Natural variant ID=VAR_061009;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34228795,PMID:11042152 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 368_368 564.0 1099.0 retained Natural variant ID=VAR_038309;Note=K->R;Dbxref=dbSNP:rs3796543 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 747_747 564.0 1099.0 not_retained Natural variant ID=VAR_038310;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs3796544,PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 774_774 564.0 1099.0 not_retained Natural variant ID=VAR_038311;Note=V->I;Dbxref=dbSNP:rs3796545 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 865_865 564.0 1099.0 not_retained Natural variant ID=VAR_038312;Note=T->A;Dbxref=dbSNP:rs12498340 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 1030_1030 564.0 1099.0 not_retained Natural variant ID=VAR_038313;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15865210;Dbxref=dbSNP:rs8340,PMID:15865210 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 167_167 564.0 1099.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 167_167 564.0 1099.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 309_309 564.0 1099.0 retained Sequence conflict Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 428_428 564.0 1099.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 428_428 564.0 1099.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 470_470 564.0 1099.0 retained Sequence conflict Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 489_489 564.0 1099.0 retained Sequence conflict Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000205214 Q4L235 10 15 498_498 564.0 1099.0 retained Sequence conflict Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 1_1098 564.0 858.0 not_retained Chain ID=PRO_0000315803;Note=Beta-alanine-activating enzyme Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 553_630 564.0 858.0 not_retained Domain Note=Carrier;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 198_206 564.0 858.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 428_428 564.0 858.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 442_442 564.0 858.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 527_527 564.0 858.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 589_589 564.0 858.0 not_retained Modified residue Note=O-(pantetheine 4'-phosphoryl)serine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 649_649 564.0 858.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 724_724 564.0 858.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 1_100 564.0 858.0 retained Alternative sequence ID=VSP_030707;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 831_857 564.0 858.0 not_retained Alternative sequence ID=VSP_030710;Note=In isoform 4. CYNGLVYVLKSNSGEKYWMFTTEDAVK->LAVLYQWTNLFIPVYLTIRAKNIFWFP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 831_841 564.0 858.0 not_retained Alternative sequence ID=VSP_030711;Note=In isoform 3. CYNGLVYVLKS->KFLNLRFVELN;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 842_1098 564.0 858.0 not_retained Alternative sequence ID=VSP_030712;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 858_1098 564.0 858.0 not_retained Alternative sequence ID=VSP_030713;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 61_61 564.0 858.0 retained Natural variant ID=VAR_061008;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34543011,PMID:11042152 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 93_93 564.0 858.0 retained Natural variant ID=VAR_061009;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34228795,PMID:11042152 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 368_368 564.0 858.0 retained Natural variant ID=VAR_038309;Note=K->R;Dbxref=dbSNP:rs3796543 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 747_747 564.0 858.0 not_retained Natural variant ID=VAR_038310;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs3796544,PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 774_774 564.0 858.0 not_retained Natural variant ID=VAR_038311;Note=V->I;Dbxref=dbSNP:rs3796545 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 865_865 564.0 858.0 not_retained Natural variant ID=VAR_038312;Note=T->A;Dbxref=dbSNP:rs12498340 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 1030_1030 564.0 858.0 not_retained Natural variant ID=VAR_038313;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15865210;Dbxref=dbSNP:rs8340,PMID:15865210 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 167_167 564.0 858.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 167_167 564.0 858.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 309_309 564.0 858.0 retained Sequence conflict Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 428_428 564.0 858.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 428_428 564.0 858.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 470_470 564.0 858.0 retained Sequence conflict Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 489_489 564.0 858.0 retained Sequence conflict Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000451613 Q4L235 10 12 498_498 564.0 858.0 retained Sequence conflict Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 1_1098 564.0 842.0 not_retained Chain ID=PRO_0000315803;Note=Beta-alanine-activating enzyme Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 553_630 564.0 842.0 not_retained Domain Note=Carrier;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 198_206 564.0 842.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 428_428 564.0 842.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 442_442 564.0 842.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 527_527 564.0 842.0 retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 589_589 564.0 842.0 not_retained Modified residue Note=O-(pantetheine 4'-phosphoryl)serine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 649_649 564.0 842.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 724_724 564.0 842.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 1_100 564.0 842.0 retained Alternative sequence ID=VSP_030707;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 831_857 564.0 842.0 not_retained Alternative sequence ID=VSP_030710;Note=In isoform 4. CYNGLVYVLKSNSGEKYWMFTTEDAVK->LAVLYQWTNLFIPVYLTIRAKNIFWFP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 831_841 564.0 842.0 not_retained Alternative sequence ID=VSP_030711;Note=In isoform 3. CYNGLVYVLKS->KFLNLRFVELN;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 842_1098 564.0 842.0 not_retained Alternative sequence ID=VSP_030712;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 858_1098 564.0 842.0 not_retained Alternative sequence ID=VSP_030713;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 61_61 564.0 842.0 retained Natural variant ID=VAR_061008;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34543011,PMID:11042152 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 93_93 564.0 842.0 retained Natural variant ID=VAR_061009;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34228795,PMID:11042152 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 368_368 564.0 842.0 retained Natural variant ID=VAR_038309;Note=K->R;Dbxref=dbSNP:rs3796543 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 747_747 564.0 842.0 not_retained Natural variant ID=VAR_038310;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs3796544,PMID:15489334 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 774_774 564.0 842.0 not_retained Natural variant ID=VAR_038311;Note=V->I;Dbxref=dbSNP:rs3796545 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 865_865 564.0 842.0 not_retained Natural variant ID=VAR_038312;Note=T->A;Dbxref=dbSNP:rs12498340 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 1030_1030 564.0 842.0 not_retained Natural variant ID=VAR_038313;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15865210;Dbxref=dbSNP:rs8340,PMID:15865210 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 167_167 564.0 842.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 167_167 564.0 842.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 309_309 564.0 842.0 retained Sequence conflict Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 428_428 564.0 842.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 428_428 564.0 842.0 retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 470_470 564.0 842.0 retained Sequence conflict Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 489_489 564.0 842.0 retained Sequence conflict Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57217508 - LRRC66 chr4:52869558 ENST00000502617 Q4L235 10 11 498_498 564.0 842.0 retained Sequence conflict Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 1_1098 122.66666666666667 999.0 not_retained Chain ID=PRO_0000315803;Note=Beta-alanine-activating enzyme Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 553_630 122.66666666666667 999.0 not_retained Domain Note=Carrier;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 198_206 122.66666666666667 999.0 not_retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 428_428 122.66666666666667 999.0 not_retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 442_442 122.66666666666667 999.0 not_retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 527_527 122.66666666666667 999.0 not_retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 589_589 122.66666666666667 999.0 not_retained Modified residue Note=O-(pantetheine 4'-phosphoryl)serine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 649_649 122.66666666666667 999.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 724_724 122.66666666666667 999.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 1_100 122.66666666666667 999.0 retained Alternative sequence ID=VSP_030707;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 831_857 122.66666666666667 999.0 not_retained Alternative sequence ID=VSP_030710;Note=In isoform 4. CYNGLVYVLKSNSGEKYWMFTTEDAVK->LAVLYQWTNLFIPVYLTIRAKNIFWFP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 831_841 122.66666666666667 999.0 not_retained Alternative sequence ID=VSP_030711;Note=In isoform 3. CYNGLVYVLKS->KFLNLRFVELN;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 842_1098 122.66666666666667 999.0 not_retained Alternative sequence ID=VSP_030712;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 858_1098 122.66666666666667 999.0 not_retained Alternative sequence ID=VSP_030713;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 61_61 122.66666666666667 999.0 retained Natural variant ID=VAR_061008;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34543011,PMID:11042152 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 93_93 122.66666666666667 999.0 retained Natural variant ID=VAR_061009;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34228795,PMID:11042152 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 368_368 122.66666666666667 999.0 not_retained Natural variant ID=VAR_038309;Note=K->R;Dbxref=dbSNP:rs3796543 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 747_747 122.66666666666667 999.0 not_retained Natural variant ID=VAR_038310;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs3796544,PMID:15489334 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 774_774 122.66666666666667 999.0 not_retained Natural variant ID=VAR_038311;Note=V->I;Dbxref=dbSNP:rs3796545 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 865_865 122.66666666666667 999.0 not_retained Natural variant ID=VAR_038312;Note=T->A;Dbxref=dbSNP:rs12498340 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 1030_1030 122.66666666666667 999.0 not_retained Natural variant ID=VAR_038313;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15865210;Dbxref=dbSNP:rs8340,PMID:15865210 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 167_167 122.66666666666667 999.0 not_retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 167_167 122.66666666666667 999.0 not_retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 309_309 122.66666666666667 999.0 not_retained Sequence conflict Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 428_428 122.66666666666667 999.0 not_retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 428_428 122.66666666666667 999.0 not_retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 470_470 122.66666666666667 999.0 not_retained Sequence conflict Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 489_489 122.66666666666667 999.0 not_retained Sequence conflict Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000513376 Q4L235 3 14 498_498 122.66666666666667 999.0 not_retained Sequence conflict Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 1_1098 222.66666666666666 1099.0 not_retained Chain ID=PRO_0000315803;Note=Beta-alanine-activating enzyme Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 553_630 222.66666666666666 1099.0 not_retained Domain Note=Carrier;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 198_206 222.66666666666666 1099.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 428_428 222.66666666666666 1099.0 not_retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 442_442 222.66666666666666 1099.0 not_retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 527_527 222.66666666666666 1099.0 not_retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 589_589 222.66666666666666 1099.0 not_retained Modified residue Note=O-(pantetheine 4'-phosphoryl)serine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 649_649 222.66666666666666 1099.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 724_724 222.66666666666666 1099.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 1_100 222.66666666666666 1099.0 retained Alternative sequence ID=VSP_030707;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 831_857 222.66666666666666 1099.0 not_retained Alternative sequence ID=VSP_030710;Note=In isoform 4. CYNGLVYVLKSNSGEKYWMFTTEDAVK->LAVLYQWTNLFIPVYLTIRAKNIFWFP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 831_841 222.66666666666666 1099.0 not_retained Alternative sequence ID=VSP_030711;Note=In isoform 3. CYNGLVYVLKS->KFLNLRFVELN;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 842_1098 222.66666666666666 1099.0 not_retained Alternative sequence ID=VSP_030712;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 858_1098 222.66666666666666 1099.0 not_retained Alternative sequence ID=VSP_030713;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 61_61 222.66666666666666 1099.0 retained Natural variant ID=VAR_061008;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34543011,PMID:11042152 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 93_93 222.66666666666666 1099.0 retained Natural variant ID=VAR_061009;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34228795,PMID:11042152 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 368_368 222.66666666666666 1099.0 not_retained Natural variant ID=VAR_038309;Note=K->R;Dbxref=dbSNP:rs3796543 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 747_747 222.66666666666666 1099.0 not_retained Natural variant ID=VAR_038310;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs3796544,PMID:15489334 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 774_774 222.66666666666666 1099.0 not_retained Natural variant ID=VAR_038311;Note=V->I;Dbxref=dbSNP:rs3796545 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 865_865 222.66666666666666 1099.0 not_retained Natural variant ID=VAR_038312;Note=T->A;Dbxref=dbSNP:rs12498340 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 1030_1030 222.66666666666666 1099.0 not_retained Natural variant ID=VAR_038313;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15865210;Dbxref=dbSNP:rs8340,PMID:15865210 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 167_167 222.66666666666666 1099.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 167_167 222.66666666666666 1099.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 309_309 222.66666666666666 1099.0 not_retained Sequence conflict Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 428_428 222.66666666666666 1099.0 not_retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 428_428 222.66666666666666 1099.0 not_retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 470_470 222.66666666666666 1099.0 not_retained Sequence conflict Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 489_489 222.66666666666666 1099.0 not_retained Sequence conflict Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000205214 Q4L235 4 15 498_498 222.66666666666666 1099.0 not_retained Sequence conflict Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 1_1098 222.66666666666666 858.0 not_retained Chain ID=PRO_0000315803;Note=Beta-alanine-activating enzyme Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 553_630 222.66666666666666 858.0 not_retained Domain Note=Carrier;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 198_206 222.66666666666666 858.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 428_428 222.66666666666666 858.0 not_retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 442_442 222.66666666666666 858.0 not_retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 527_527 222.66666666666666 858.0 not_retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 589_589 222.66666666666666 858.0 not_retained Modified residue Note=O-(pantetheine 4'-phosphoryl)serine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 649_649 222.66666666666666 858.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 724_724 222.66666666666666 858.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 1_100 222.66666666666666 858.0 retained Alternative sequence ID=VSP_030707;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 831_857 222.66666666666666 858.0 not_retained Alternative sequence ID=VSP_030710;Note=In isoform 4. CYNGLVYVLKSNSGEKYWMFTTEDAVK->LAVLYQWTNLFIPVYLTIRAKNIFWFP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 831_841 222.66666666666666 858.0 not_retained Alternative sequence ID=VSP_030711;Note=In isoform 3. CYNGLVYVLKS->KFLNLRFVELN;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 842_1098 222.66666666666666 858.0 not_retained Alternative sequence ID=VSP_030712;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 858_1098 222.66666666666666 858.0 not_retained Alternative sequence ID=VSP_030713;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 61_61 222.66666666666666 858.0 retained Natural variant ID=VAR_061008;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34543011,PMID:11042152 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 93_93 222.66666666666666 858.0 retained Natural variant ID=VAR_061009;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34228795,PMID:11042152 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 368_368 222.66666666666666 858.0 not_retained Natural variant ID=VAR_038309;Note=K->R;Dbxref=dbSNP:rs3796543 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 747_747 222.66666666666666 858.0 not_retained Natural variant ID=VAR_038310;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs3796544,PMID:15489334 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 774_774 222.66666666666666 858.0 not_retained Natural variant ID=VAR_038311;Note=V->I;Dbxref=dbSNP:rs3796545 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 865_865 222.66666666666666 858.0 not_retained Natural variant ID=VAR_038312;Note=T->A;Dbxref=dbSNP:rs12498340 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 1030_1030 222.66666666666666 858.0 not_retained Natural variant ID=VAR_038313;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15865210;Dbxref=dbSNP:rs8340,PMID:15865210 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 167_167 222.66666666666666 858.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 167_167 222.66666666666666 858.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 309_309 222.66666666666666 858.0 not_retained Sequence conflict Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 428_428 222.66666666666666 858.0 not_retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 428_428 222.66666666666666 858.0 not_retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 470_470 222.66666666666666 858.0 not_retained Sequence conflict Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 489_489 222.66666666666666 858.0 not_retained Sequence conflict Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000451613 Q4L235 4 12 498_498 222.66666666666666 858.0 not_retained Sequence conflict Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 1_1098 222.66666666666666 842.0 not_retained Chain ID=PRO_0000315803;Note=Beta-alanine-activating enzyme Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 553_630 222.66666666666666 842.0 not_retained Domain Note=Carrier;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 198_206 222.66666666666666 842.0 retained Nucleotide binding Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 428_428 222.66666666666666 842.0 not_retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 442_442 222.66666666666666 842.0 not_retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 527_527 222.66666666666666 842.0 not_retained Binding site Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 589_589 222.66666666666666 842.0 not_retained Modified residue Note=O-(pantetheine 4'-phosphoryl)serine;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00258 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 649_649 222.66666666666666 842.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 724_724 222.66666666666666 842.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 1_100 222.66666666666666 842.0 retained Alternative sequence ID=VSP_030707;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 831_857 222.66666666666666 842.0 not_retained Alternative sequence ID=VSP_030710;Note=In isoform 4. CYNGLVYVLKSNSGEKYWMFTTEDAVK->LAVLYQWTNLFIPVYLTIRAKNIFWFP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 831_841 222.66666666666666 842.0 not_retained Alternative sequence ID=VSP_030711;Note=In isoform 3. CYNGLVYVLKS->KFLNLRFVELN;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 842_1098 222.66666666666666 842.0 not_retained Alternative sequence ID=VSP_030712;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 858_1098 222.66666666666666 842.0 not_retained Alternative sequence ID=VSP_030713;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 61_61 222.66666666666666 842.0 retained Natural variant ID=VAR_061008;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34543011,PMID:11042152 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 93_93 222.66666666666666 842.0 retained Natural variant ID=VAR_061009;Note=P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11042152;Dbxref=dbSNP:rs34228795,PMID:11042152 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 368_368 222.66666666666666 842.0 not_retained Natural variant ID=VAR_038309;Note=K->R;Dbxref=dbSNP:rs3796543 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 747_747 222.66666666666666 842.0 not_retained Natural variant ID=VAR_038310;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.2;Dbxref=dbSNP:rs3796544,PMID:15489334 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 774_774 222.66666666666666 842.0 not_retained Natural variant ID=VAR_038311;Note=V->I;Dbxref=dbSNP:rs3796545 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 865_865 222.66666666666666 842.0 not_retained Natural variant ID=VAR_038312;Note=T->A;Dbxref=dbSNP:rs12498340 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 1030_1030 222.66666666666666 842.0 not_retained Natural variant ID=VAR_038313;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15865210;Dbxref=dbSNP:rs8340,PMID:15865210 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 167_167 222.66666666666666 842.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 167_167 222.66666666666666 842.0 retained Sequence conflict Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 309_309 222.66666666666666 842.0 not_retained Sequence conflict Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 428_428 222.66666666666666 842.0 not_retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 428_428 222.66666666666666 842.0 not_retained Sequence conflict Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 470_470 222.66666666666666 842.0 not_retained Sequence conflict Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 489_489 222.66666666666666 842.0 not_retained Sequence conflict Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDH chr4:57244314 - CC2D2A chr4:15564978 ENST00000502617 Q4L235 4 11 498_498 222.66666666666666 842.0 not_retained Sequence conflict Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 1_309 136.33333333333334 310.0 not_retained Chain ID=PRO_0000175736;Note=L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 86_91 136.33333333333334 310.0 retained Region Note=Coenzyme A binding;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:18022563,ECO:0007744|PDB:2C43,ECO:0007744|PDB:2CG5;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 108_111 136.33333333333334 310.0 retained Region Note=Coenzyme A binding;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:18022563,ECO:0007744|PDB:2C43,ECO:0007744|PDB:2CG5;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 181_185 136.33333333333334 310.0 not_retained Region Note=Coenzyme A binding;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:18022563,ECO:0007744|PDB:2C43,ECO:0007744|PDB:2CG5;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 129_129 136.33333333333334 310.0 retained Mutagenesis Note=Reduces affinity for magnesium by 10-fold%2C and holo-[acyl-carrier-protein] synthase activity by 30000-fold. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18022563;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 181_181 136.33333333333334 310.0 not_retained Mutagenesis Note=Reduces affinity for magnesium by 20-fold%2C and holo-[acyl-carrier-protein] synthase activity by 6500-fold. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18022563;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 47_47 136.33333333333334 310.0 retained Mutagenesis Note=Reduces affinity for magnesium by 7-fold%2C and holo-[acyl-carrier-protein] synthase activity by 2-fold. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18022563;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 258_258 136.33333333333334 310.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17525332,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:17525332,PMID:18669648,PMID:20068231,PMID:23186163 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 138_138 136.33333333333334 310.0 retained Alternative sequence ID=VSP_055783;Note=In isoform 2. R->T;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 139_309 136.33333333333334 310.0 not_retained Alternative sequence ID=VSP_055784;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 47_47 136.33333333333334 310.0 retained Mutagenesis Note=Reduces affinity for magnesium by 7-fold%2C and holo-[acyl-carrier-protein] synthase activity by 2-fold. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18022563;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 86_86 136.33333333333334 310.0 retained Mutagenesis Note=Reduces affinity for magnesium and coenzyme A%2C and reduces holo-[acyl-carrier-protein] synthase activity by 7-fold. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18022563;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 111_111 136.33333333333334 310.0 retained Mutagenesis Note=Reduces affinity for magnesium by 75-fold%2C and holo-[acyl-carrier-protein] synthase activity by 150-fold. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18022563;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 112_112 136.33333333333334 310.0 retained Mutagenesis Note=Reduces affinity for magnesium by 200-fold and abolishes holo-[acyl-carrier-protein] synthase activity%3B when associated with Q-181. Q->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18022563;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 129_129 136.33333333333334 310.0 retained Mutagenesis Note=Reduces affinity for magnesium by 10-fold%2C and holo-[acyl-carrier-protein] synthase activity by 30000-fold. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18022563;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 181_181 136.33333333333334 310.0 not_retained Mutagenesis Note=Reduces affinity for magnesium by 20-fold%2C and holo-[acyl-carrier-protein] synthase activity by 6500-fold. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18022563;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 181_181 136.33333333333334 310.0 not_retained Mutagenesis Note=Reduces affinity for magnesium by 20-fold%2C and holo-[acyl-carrier-protein] synthase activity by 6500-fold. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18022563;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 185_185 136.33333333333334 310.0 not_retained Mutagenesis Note=Reduces holo-[acyl-carrier-protein] synthase activity by 2000-fold%2C with only minor change in the affinity for magnesium and coenzyme A. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18022563;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 136_141 136.33333333333334 310.0 not_retained Sequence conflict Note=PGRGSI->FQVVVQF;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 307_309 136.33333333333334 310.0 not_retained Sequence conflict Note=TKS->YKVMMIP;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 17_21 136.33333333333334 310.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 23_25 136.33333333333334 310.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 30_38 136.33333333333334 310.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 42_49 136.33333333333334 310.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 54_74 136.33333333333334 310.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 79_81 136.33333333333334 310.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 84_86 136.33333333333334 310.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 92_94 136.33333333333334 310.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 102_104 136.33333333333334 310.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 106_112 136.33333333333334 310.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 115_132 136.33333333333334 310.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 137_139 136.33333333333334 310.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 141_147 136.33333333333334 310.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 149_151 136.33333333333334 310.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 154_160 136.33333333333334 310.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 163_165 136.33333333333334 310.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 166_187 136.33333333333334 310.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 190_192 136.33333333333334 310.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2BYD Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 195_197 136.33333333333334 310.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 198_201 136.33333333333334 310.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 203_206 136.33333333333334 310.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2BYD Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 217_220 136.33333333333334 310.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 228_236 136.33333333333334 310.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 239_246 136.33333333333334 310.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 270_272 136.33333333333334 310.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 274_277 136.33333333333334 310.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 278_280 136.33333333333334 310.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 289_291 136.33333333333334 310.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 298_300 136.33333333333334 310.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + ABTB2 chr11:34226237 ENST00000278618 Q9NRN7 2 6 305_307 136.33333333333334 310.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2BYD Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 1_309 136.33333333333334 310.0 not_retained Chain ID=PRO_0000175736;Note=L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 86_91 136.33333333333334 310.0 retained Region Note=Coenzyme A binding;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:18022563,ECO:0007744|PDB:2C43,ECO:0007744|PDB:2CG5;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 108_111 136.33333333333334 310.0 retained Region Note=Coenzyme A binding;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:18022563,ECO:0007744|PDB:2C43,ECO:0007744|PDB:2CG5;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 181_185 136.33333333333334 310.0 not_retained Region Note=Coenzyme A binding;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:18022563,ECO:0007744|PDB:2C43,ECO:0007744|PDB:2CG5;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 129_129 136.33333333333334 310.0 retained Mutagenesis Note=Reduces affinity for magnesium by 10-fold%2C and holo-[acyl-carrier-protein] synthase activity by 30000-fold. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18022563;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 181_181 136.33333333333334 310.0 not_retained Mutagenesis Note=Reduces affinity for magnesium by 20-fold%2C and holo-[acyl-carrier-protein] synthase activity by 6500-fold. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18022563;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 47_47 136.33333333333334 310.0 retained Mutagenesis Note=Reduces affinity for magnesium by 7-fold%2C and holo-[acyl-carrier-protein] synthase activity by 2-fold. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18022563;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 258_258 136.33333333333334 310.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17525332,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:17525332,PMID:18669648,PMID:20068231,PMID:23186163 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 138_138 136.33333333333334 310.0 retained Alternative sequence ID=VSP_055783;Note=In isoform 2. R->T;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 139_309 136.33333333333334 310.0 not_retained Alternative sequence ID=VSP_055784;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 47_47 136.33333333333334 310.0 retained Mutagenesis Note=Reduces affinity for magnesium by 7-fold%2C and holo-[acyl-carrier-protein] synthase activity by 2-fold. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18022563;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 86_86 136.33333333333334 310.0 retained Mutagenesis Note=Reduces affinity for magnesium and coenzyme A%2C and reduces holo-[acyl-carrier-protein] synthase activity by 7-fold. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18022563;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 111_111 136.33333333333334 310.0 retained Mutagenesis Note=Reduces affinity for magnesium by 75-fold%2C and holo-[acyl-carrier-protein] synthase activity by 150-fold. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18022563;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 112_112 136.33333333333334 310.0 retained Mutagenesis Note=Reduces affinity for magnesium by 200-fold and abolishes holo-[acyl-carrier-protein] synthase activity%3B when associated with Q-181. Q->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18022563;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 129_129 136.33333333333334 310.0 retained Mutagenesis Note=Reduces affinity for magnesium by 10-fold%2C and holo-[acyl-carrier-protein] synthase activity by 30000-fold. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18022563;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 181_181 136.33333333333334 310.0 not_retained Mutagenesis Note=Reduces affinity for magnesium by 20-fold%2C and holo-[acyl-carrier-protein] synthase activity by 6500-fold. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18022563;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 181_181 136.33333333333334 310.0 not_retained Mutagenesis Note=Reduces affinity for magnesium by 20-fold%2C and holo-[acyl-carrier-protein] synthase activity by 6500-fold. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18022563;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 185_185 136.33333333333334 310.0 not_retained Mutagenesis Note=Reduces holo-[acyl-carrier-protein] synthase activity by 2000-fold%2C with only minor change in the affinity for magnesium and coenzyme A. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18022563;Dbxref=PMID:18022563 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 136_141 136.33333333333334 310.0 not_retained Sequence conflict Note=PGRGSI->FQVVVQF;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 307_309 136.33333333333334 310.0 not_retained Sequence conflict Note=TKS->YKVMMIP;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 17_21 136.33333333333334 310.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 23_25 136.33333333333334 310.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 30_38 136.33333333333334 310.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 42_49 136.33333333333334 310.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 54_74 136.33333333333334 310.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 79_81 136.33333333333334 310.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 84_86 136.33333333333334 310.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 92_94 136.33333333333334 310.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 102_104 136.33333333333334 310.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 106_112 136.33333333333334 310.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 115_132 136.33333333333334 310.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 137_139 136.33333333333334 310.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 141_147 136.33333333333334 310.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 149_151 136.33333333333334 310.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 154_160 136.33333333333334 310.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 163_165 136.33333333333334 310.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 166_187 136.33333333333334 310.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 190_192 136.33333333333334 310.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2BYD Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 195_197 136.33333333333334 310.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 198_201 136.33333333333334 310.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 203_206 136.33333333333334 310.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2BYD Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 217_220 136.33333333333334 310.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 228_236 136.33333333333334 310.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 239_246 136.33333333333334 310.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 270_272 136.33333333333334 310.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 274_277 136.33333333333334 310.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 278_280 136.33333333333334 310.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 289_291 136.33333333333334 310.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 298_300 136.33333333333334 310.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2C43 Hgene AASDHPPT chr11:105950419 + CARD16 chr11:104915385 ENST00000278618 Q9NRN7 2 6 305_307 136.33333333333334 310.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:2BYD Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 1_32 728.0 927.0 retained Transit peptide Note=Mitochondrion;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 33_926 728.0 927.0 not_retained Chain ID=PRO_0000001052;Note=Alpha-aminoadipic semialdehyde synthase%2C mitochondrial Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 488_491 728.0 927.0 retained Nucleotide binding Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 603_605 728.0 927.0 retained Nucleotide binding Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 33_455 728.0 927.0 retained Region Note=Lysine-ketoglutarate reductase Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 477_926 728.0 927.0 not_retained Region Note=Saccharopine dehydrogenase Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 577_578 728.0 927.0 retained Region Note=Saccharopine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 724_726 728.0 927.0 retained Region Note=Saccharopine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 604_604 728.0 927.0 retained Binding site Note=Saccharopine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 653_653 728.0 927.0 retained Binding site Note=NADP%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 703_703 728.0 927.0 retained Binding site Note=Saccharopine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 48_48 728.0 927.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 56_56 728.0 927.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 93_93 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 93_93 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 128_128 728.0 927.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 138_138 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 138_138 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 274_274 728.0 927.0 retained Modified residue Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 286_286 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 286_286 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 333_333 728.0 927.0 retained Modified residue Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 458_458 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 458_458 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 523_523 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 523_523 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 535_535 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 535_535 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 584_584 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 584_584 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 707_707 728.0 927.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 732_732 728.0 927.0 not_retained Modified residue Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 739_739 728.0 927.0 not_retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 761_761 728.0 927.0 not_retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 761_761 728.0 927.0 not_retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 780_780 728.0 927.0 not_retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 589_589 728.0 927.0 retained Sequence conflict Note=S->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 483_486 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 492_499 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 500_503 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 507_512 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 514_523 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 527_530 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 533_535 728.0 927.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 537_545 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 548_552 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 556_558 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 559_569 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 572_577 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 581_584 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 587_593 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 596_598 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 603_606 728.0 927.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 607_620 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 621_623 728.0 927.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 625_637 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 639_641 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 650_652 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 655_660 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 665_669 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 672_676 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 679_685 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 687_689 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 697_701 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 703_705 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 708_712 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 718_727 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 730_740 728.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 760_768 728.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 775_785 728.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 787_789 728.0 927.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 791_800 728.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 801_803 728.0 927.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 814_825 728.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 834_845 728.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 851_861 728.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 864_866 728.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5L76 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 869_886 728.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 894_896 728.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 901_910 728.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 911_915 728.0 927.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000393376 Q9UDR5 18 23 917_924 728.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 1_32 728.0 927.0 retained Transit peptide Note=Mitochondrion;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 33_926 728.0 927.0 not_retained Chain ID=PRO_0000001052;Note=Alpha-aminoadipic semialdehyde synthase%2C mitochondrial Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 488_491 728.0 927.0 retained Nucleotide binding Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 603_605 728.0 927.0 retained Nucleotide binding Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 33_455 728.0 927.0 retained Region Note=Lysine-ketoglutarate reductase Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 477_926 728.0 927.0 not_retained Region Note=Saccharopine dehydrogenase Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 577_578 728.0 927.0 retained Region Note=Saccharopine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 724_726 728.0 927.0 retained Region Note=Saccharopine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 604_604 728.0 927.0 retained Binding site Note=Saccharopine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 653_653 728.0 927.0 retained Binding site Note=NADP%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 703_703 728.0 927.0 retained Binding site Note=Saccharopine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 48_48 728.0 927.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 56_56 728.0 927.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 93_93 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 93_93 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 128_128 728.0 927.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 138_138 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 138_138 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 274_274 728.0 927.0 retained Modified residue Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 286_286 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 286_286 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 333_333 728.0 927.0 retained Modified residue Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 458_458 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 458_458 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 523_523 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 523_523 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 535_535 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 535_535 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 584_584 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 584_584 728.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 707_707 728.0 927.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 732_732 728.0 927.0 not_retained Modified residue Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 739_739 728.0 927.0 not_retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 761_761 728.0 927.0 not_retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 761_761 728.0 927.0 not_retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 780_780 728.0 927.0 not_retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 589_589 728.0 927.0 retained Sequence conflict Note=S->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 483_486 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 492_499 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 500_503 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 507_512 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 514_523 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 527_530 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 533_535 728.0 927.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 537_545 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 548_552 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 556_558 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 559_569 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 572_577 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 581_584 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 587_593 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 596_598 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 603_606 728.0 927.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 607_620 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 621_623 728.0 927.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 625_637 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 639_641 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 650_652 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 655_660 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 665_669 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 672_676 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 679_685 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 687_689 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 697_701 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 703_705 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 708_712 728.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 718_727 728.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 730_740 728.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 760_768 728.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 775_785 728.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 787_789 728.0 927.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 791_800 728.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 801_803 728.0 927.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 814_825 728.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 834_845 728.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 851_861 728.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 864_866 728.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5L76 Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 869_886 728.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 894_896 728.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 901_910 728.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 911_915 728.0 927.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121726066 - CADPS2 chr7:122377122 ENST00000417368 Q9UDR5 19 24 917_924 728.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 1_32 672.0 927.0 retained Transit peptide Note=Mitochondrion;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 33_926 672.0 927.0 not_retained Chain ID=PRO_0000001052;Note=Alpha-aminoadipic semialdehyde synthase%2C mitochondrial Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 488_491 672.0 927.0 retained Nucleotide binding Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 603_605 672.0 927.0 retained Nucleotide binding Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 33_455 672.0 927.0 retained Region Note=Lysine-ketoglutarate reductase Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 477_926 672.0 927.0 not_retained Region Note=Saccharopine dehydrogenase Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 577_578 672.0 927.0 retained Region Note=Saccharopine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 724_726 672.0 927.0 not_retained Region Note=Saccharopine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 604_604 672.0 927.0 retained Binding site Note=Saccharopine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 653_653 672.0 927.0 retained Binding site Note=NADP%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 703_703 672.0 927.0 not_retained Binding site Note=Saccharopine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 48_48 672.0 927.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 56_56 672.0 927.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 93_93 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 93_93 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 128_128 672.0 927.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 138_138 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 138_138 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 274_274 672.0 927.0 retained Modified residue Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 286_286 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 286_286 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 333_333 672.0 927.0 retained Modified residue Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 458_458 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 458_458 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 523_523 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 523_523 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 535_535 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 535_535 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 584_584 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 584_584 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 707_707 672.0 927.0 not_retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 732_732 672.0 927.0 not_retained Modified residue Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 739_739 672.0 927.0 not_retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 761_761 672.0 927.0 not_retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 761_761 672.0 927.0 not_retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 780_780 672.0 927.0 not_retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 589_589 672.0 927.0 retained Sequence conflict Note=S->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 483_486 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 492_499 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 500_503 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 507_512 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 514_523 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 527_530 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 533_535 672.0 927.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 537_545 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 548_552 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 556_558 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 559_569 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 572_577 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 581_584 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 587_593 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 596_598 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 603_606 672.0 927.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 607_620 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 621_623 672.0 927.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 625_637 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 639_641 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 650_652 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 655_660 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 665_669 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 672_676 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 679_685 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 687_689 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 697_701 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 703_705 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 708_712 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 718_727 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 730_740 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 760_768 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 775_785 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 787_789 672.0 927.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 791_800 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 801_803 672.0 927.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 814_825 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 834_845 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 851_861 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 864_866 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5L76 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 869_886 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 894_896 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 901_910 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 911_915 672.0 927.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000393376 Q9UDR5 17 23 917_924 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 1_32 672.0 927.0 retained Transit peptide Note=Mitochondrion;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 33_926 672.0 927.0 not_retained Chain ID=PRO_0000001052;Note=Alpha-aminoadipic semialdehyde synthase%2C mitochondrial Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 488_491 672.0 927.0 retained Nucleotide binding Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 603_605 672.0 927.0 retained Nucleotide binding Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 33_455 672.0 927.0 retained Region Note=Lysine-ketoglutarate reductase Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 477_926 672.0 927.0 not_retained Region Note=Saccharopine dehydrogenase Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 577_578 672.0 927.0 retained Region Note=Saccharopine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 724_726 672.0 927.0 not_retained Region Note=Saccharopine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 604_604 672.0 927.0 retained Binding site Note=Saccharopine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 653_653 672.0 927.0 retained Binding site Note=NADP%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 703_703 672.0 927.0 not_retained Binding site Note=Saccharopine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 48_48 672.0 927.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 56_56 672.0 927.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 93_93 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 93_93 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 128_128 672.0 927.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 138_138 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 138_138 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 274_274 672.0 927.0 retained Modified residue Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 286_286 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 286_286 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 333_333 672.0 927.0 retained Modified residue Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 458_458 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 458_458 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 523_523 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 523_523 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 535_535 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 535_535 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 584_584 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 584_584 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 707_707 672.0 927.0 not_retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 732_732 672.0 927.0 not_retained Modified residue Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 739_739 672.0 927.0 not_retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 761_761 672.0 927.0 not_retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 761_761 672.0 927.0 not_retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 780_780 672.0 927.0 not_retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 589_589 672.0 927.0 retained Sequence conflict Note=S->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 483_486 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 492_499 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 500_503 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 507_512 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 514_523 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 527_530 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 533_535 672.0 927.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 537_545 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 548_552 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 556_558 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 559_569 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 572_577 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 581_584 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 587_593 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 596_598 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 603_606 672.0 927.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 607_620 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 621_623 672.0 927.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 625_637 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 639_641 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 650_652 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 655_660 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 665_669 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 672_676 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 679_685 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 687_689 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 697_701 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 703_705 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 708_712 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 718_727 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 730_740 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 760_768 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 775_785 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 787_789 672.0 927.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 791_800 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 801_803 672.0 927.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 814_825 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 834_845 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 851_861 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 864_866 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5L76 Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 869_886 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 894_896 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 901_910 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 911_915 672.0 927.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731756 - DNM3 chr1:172100314 ENST00000417368 Q9UDR5 18 24 917_924 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 1_32 672.0 927.0 retained Transit peptide Note=Mitochondrion;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 33_926 672.0 927.0 not_retained Chain ID=PRO_0000001052;Note=Alpha-aminoadipic semialdehyde synthase%2C mitochondrial Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 488_491 672.0 927.0 retained Nucleotide binding Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 603_605 672.0 927.0 retained Nucleotide binding Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 33_455 672.0 927.0 retained Region Note=Lysine-ketoglutarate reductase Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 477_926 672.0 927.0 not_retained Region Note=Saccharopine dehydrogenase Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 577_578 672.0 927.0 retained Region Note=Saccharopine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 724_726 672.0 927.0 not_retained Region Note=Saccharopine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 604_604 672.0 927.0 retained Binding site Note=Saccharopine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 653_653 672.0 927.0 retained Binding site Note=NADP%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 703_703 672.0 927.0 not_retained Binding site Note=Saccharopine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 48_48 672.0 927.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 56_56 672.0 927.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 93_93 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 93_93 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 128_128 672.0 927.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 138_138 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 138_138 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 274_274 672.0 927.0 retained Modified residue Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 286_286 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 286_286 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 333_333 672.0 927.0 retained Modified residue Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 458_458 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 458_458 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 523_523 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 523_523 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 535_535 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 535_535 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 584_584 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 584_584 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 707_707 672.0 927.0 not_retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 732_732 672.0 927.0 not_retained Modified residue Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 739_739 672.0 927.0 not_retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 761_761 672.0 927.0 not_retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 761_761 672.0 927.0 not_retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 780_780 672.0 927.0 not_retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 589_589 672.0 927.0 retained Sequence conflict Note=S->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 483_486 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 492_499 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 500_503 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 507_512 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 514_523 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 527_530 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 533_535 672.0 927.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 537_545 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 548_552 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 556_558 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 559_569 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 572_577 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 581_584 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 587_593 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 596_598 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 603_606 672.0 927.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 607_620 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 621_623 672.0 927.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 625_637 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 639_641 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 650_652 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 655_660 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 665_669 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 672_676 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 679_685 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 687_689 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 697_701 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 703_705 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 708_712 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 718_727 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 730_740 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 760_768 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 775_785 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 787_789 672.0 927.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 791_800 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 801_803 672.0 927.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 814_825 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 834_845 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 851_861 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 864_866 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5L76 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 869_886 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 894_896 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 901_910 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 911_915 672.0 927.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000393376 Q9UDR5 17 23 917_924 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 1_32 672.0 927.0 retained Transit peptide Note=Mitochondrion;Ontology_term=ECO:0000250;evidence=ECO:0000250 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 33_926 672.0 927.0 not_retained Chain ID=PRO_0000001052;Note=Alpha-aminoadipic semialdehyde synthase%2C mitochondrial Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 488_491 672.0 927.0 retained Nucleotide binding Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 603_605 672.0 927.0 retained Nucleotide binding Note=NADP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 33_455 672.0 927.0 retained Region Note=Lysine-ketoglutarate reductase Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 477_926 672.0 927.0 not_retained Region Note=Saccharopine dehydrogenase Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 577_578 672.0 927.0 retained Region Note=Saccharopine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 724_726 672.0 927.0 not_retained Region Note=Saccharopine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 604_604 672.0 927.0 retained Binding site Note=Saccharopine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 653_653 672.0 927.0 retained Binding site Note=NADP%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 703_703 672.0 927.0 not_retained Binding site Note=Saccharopine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9P4R4 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 48_48 672.0 927.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 56_56 672.0 927.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 93_93 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 93_93 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 128_128 672.0 927.0 retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 138_138 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 138_138 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 274_274 672.0 927.0 retained Modified residue Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 286_286 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 286_286 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 333_333 672.0 927.0 retained Modified residue Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 458_458 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 458_458 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 523_523 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 523_523 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 535_535 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 535_535 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 584_584 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 584_584 672.0 927.0 retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 707_707 672.0 927.0 not_retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 732_732 672.0 927.0 not_retained Modified residue Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 739_739 672.0 927.0 not_retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 761_761 672.0 927.0 not_retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 761_761 672.0 927.0 not_retained Modified residue Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 780_780 672.0 927.0 not_retained Modified residue Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99K67 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 589_589 672.0 927.0 retained Sequence conflict Note=S->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 483_486 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 492_499 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 500_503 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 507_512 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 514_523 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 527_530 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 533_535 672.0 927.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 537_545 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 548_552 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 556_558 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 559_569 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 572_577 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 581_584 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 587_593 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 596_598 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 603_606 672.0 927.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 607_620 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 621_623 672.0 927.0 retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 625_637 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 639_641 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 650_652 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 655_660 672.0 927.0 retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 665_669 672.0 927.0 retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 672_676 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 679_685 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 687_689 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 697_701 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 703_705 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 708_712 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 718_727 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 730_740 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 760_768 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 775_785 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 787_789 672.0 927.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 791_800 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 801_803 672.0 927.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 814_825 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 834_845 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 851_861 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 864_866 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5L76 Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 869_886 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 894_896 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 901_910 672.0 927.0 not_retained Helix Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 911_915 672.0 927.0 not_retained Turn Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AASS chr7:121731757 - DNM3 chr1:172100315 ENST00000417368 Q9UDR5 18 24 917_924 672.0 927.0 not_retained Beta strand Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:5O1P Hgene AATF chr17:35310579 - AATF chr17:35311162 ENST00000225402 Q9NY61 1 12 1_1 0 561.0 not_retained Initiator methionine Note=Removed;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19413330;Dbxref=PMID:19413330 Hgene AATF chr17:35310579 - AATF chr17:35311162 ENST00000225402 Q9NY61 1 12 2_560 0 561.0 not_retained Chain ID=PRO_0000056616;Note=Protein AATF Hgene AATF chr17:35310579 - AATF chr17:35311162 ENST00000225402 Q9NY61 1 12 273_315 0 561.0 not_retained Region Note=POLR2J binding Hgene AATF chr17:35310579 - AATF chr17:35311162 ENST00000225402 Q9NY61 1 12 316_372 0 561.0 not_retained Region Note=RB1 binding Hgene AATF chr17:35310579 - AATF chr17:35311162 ENST00000225402 Q9NY61 1 12 373_472 0 561.0 not_retained Region Note=RB1 and SP1 binding Hgene AATF chr17:35310579 - AATF chr17:35311162 ENST00000225402 Q9NY61 1 12 96_195 0 561.0 not_retained Compositional bias Note=Glu-rich Hgene AATF chr17:35310579 - AATF chr17:35311162 ENST00000225402 Q9NY61 1 12 2_2 0 561.0 retained Modified residue Note=N-acetylalanine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19413330;Dbxref=PMID:19413330 Hgene AATF chr17:35310579 - AATF chr17:35311162 ENST00000225402 Q9NY61 1 12 61_61 0 561.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35310579 - AATF chr17:35311162 ENST00000225402 Q9NY61 1 12 63_63 0 561.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35310579 - AATF chr17:35311162 ENST00000225402 Q9NY61 1 12 150_150 0 561.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35310579 - AATF chr17:35311162 ENST00000225402 Q9NY61 1 12 155_155 0 561.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35310579 - AATF chr17:35311162 ENST00000225402 Q9NY61 1 12 203_203 0 561.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163 Hgene AATF chr17:35310579 - AATF chr17:35311162 ENST00000225402 Q9NY61 1 12 273_273 0 561.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35310579 - AATF chr17:35311162 ENST00000225402 Q9NY61 1 12 316_316 0 561.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692 Hgene AATF chr17:35310579 - AATF chr17:35311162 ENST00000225402 Q9NY61 1 12 320_320 0 561.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692 Hgene AATF chr17:35310579 - AATF chr17:35311162 ENST00000225402 Q9NY61 1 12 321_321 0 561.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692 Hgene AATF chr17:35310579 - AATF chr17:35311162 ENST00000225402 Q9NY61 1 12 2_3 0 561.0 retained Sequence conflict Note=AG->GR;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35310579 - AATF chr17:35311162 ENST00000225402 Q9NY61 1 12 4_5 0 561.0 not_retained Sequence conflict Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35310579 - AATF chr17:35311162 ENST00000225402 Q9NY61 1 12 139_139 0 561.0 not_retained Sequence conflict Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35310579 - AATF chr17:35311162 ENST00000225402 Q9NY61 1 12 262_262 0 561.0 not_retained Sequence conflict Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35310579 - AATF chr17:35311162 ENST00000225402 Q9NY61 1 12 272_272 0 561.0 not_retained Sequence conflict Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35310579 - AATF chr17:35311162 ENST00000225402 Q9NY61 1 12 306_306 0 561.0 not_retained Sequence conflict Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35310579 - AATF chr17:35311162 ENST00000225402 Q9NY61 1 12 402_402 0 561.0 not_retained Sequence conflict Note=D->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35311207 + AP2B1 chr17:34037253 ENST00000225402 Q9NY61 4 12 1_1 277.3333333333333 561.0 retained Initiator methionine Note=Removed;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19413330;Dbxref=PMID:19413330 Hgene AATF chr17:35311207 + AP2B1 chr17:34037253 ENST00000225402 Q9NY61 4 12 2_560 277.3333333333333 561.0 not_retained Chain ID=PRO_0000056616;Note=Protein AATF Hgene AATF chr17:35311207 + AP2B1 chr17:34037253 ENST00000225402 Q9NY61 4 12 273_315 277.3333333333333 561.0 not_retained Region Note=POLR2J binding Hgene AATF chr17:35311207 + AP2B1 chr17:34037253 ENST00000225402 Q9NY61 4 12 316_372 277.3333333333333 561.0 not_retained Region Note=RB1 binding Hgene AATF chr17:35311207 + AP2B1 chr17:34037253 ENST00000225402 Q9NY61 4 12 373_472 277.3333333333333 561.0 not_retained Region Note=RB1 and SP1 binding Hgene AATF chr17:35311207 + AP2B1 chr17:34037253 ENST00000225402 Q9NY61 4 12 96_195 277.3333333333333 561.0 retained Compositional bias Note=Glu-rich Hgene AATF chr17:35311207 + AP2B1 chr17:34037253 ENST00000225402 Q9NY61 4 12 2_2 277.3333333333333 561.0 retained Modified residue Note=N-acetylalanine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19413330;Dbxref=PMID:19413330 Hgene AATF chr17:35311207 + AP2B1 chr17:34037253 ENST00000225402 Q9NY61 4 12 61_61 277.3333333333333 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35311207 + AP2B1 chr17:34037253 ENST00000225402 Q9NY61 4 12 63_63 277.3333333333333 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35311207 + AP2B1 chr17:34037253 ENST00000225402 Q9NY61 4 12 150_150 277.3333333333333 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35311207 + AP2B1 chr17:34037253 ENST00000225402 Q9NY61 4 12 155_155 277.3333333333333 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35311207 + AP2B1 chr17:34037253 ENST00000225402 Q9NY61 4 12 203_203 277.3333333333333 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163 Hgene AATF chr17:35311207 + AP2B1 chr17:34037253 ENST00000225402 Q9NY61 4 12 273_273 277.3333333333333 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35311207 + AP2B1 chr17:34037253 ENST00000225402 Q9NY61 4 12 316_316 277.3333333333333 561.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692 Hgene AATF chr17:35311207 + AP2B1 chr17:34037253 ENST00000225402 Q9NY61 4 12 320_320 277.3333333333333 561.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692 Hgene AATF chr17:35311207 + AP2B1 chr17:34037253 ENST00000225402 Q9NY61 4 12 321_321 277.3333333333333 561.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692 Hgene AATF chr17:35311207 + AP2B1 chr17:34037253 ENST00000225402 Q9NY61 4 12 2_3 277.3333333333333 561.0 retained Sequence conflict Note=AG->GR;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35311207 + AP2B1 chr17:34037253 ENST00000225402 Q9NY61 4 12 4_5 277.3333333333333 561.0 retained Sequence conflict Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35311207 + AP2B1 chr17:34037253 ENST00000225402 Q9NY61 4 12 139_139 277.3333333333333 561.0 retained Sequence conflict Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35311207 + AP2B1 chr17:34037253 ENST00000225402 Q9NY61 4 12 262_262 277.3333333333333 561.0 retained Sequence conflict Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35311207 + AP2B1 chr17:34037253 ENST00000225402 Q9NY61 4 12 272_272 277.3333333333333 561.0 retained Sequence conflict Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35311207 + AP2B1 chr17:34037253 ENST00000225402 Q9NY61 4 12 306_306 277.3333333333333 561.0 not_retained Sequence conflict Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35311207 + AP2B1 chr17:34037253 ENST00000225402 Q9NY61 4 12 402_402 277.3333333333333 561.0 not_retained Sequence conflict Note=D->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35311207 + TADA2A chr17:35834661 ENST00000225402 Q9NY61 4 12 1_1 277.3333333333333 561.0 retained Initiator methionine Note=Removed;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19413330;Dbxref=PMID:19413330 Hgene AATF chr17:35311207 + TADA2A chr17:35834661 ENST00000225402 Q9NY61 4 12 2_560 277.3333333333333 561.0 not_retained Chain ID=PRO_0000056616;Note=Protein AATF Hgene AATF chr17:35311207 + TADA2A chr17:35834661 ENST00000225402 Q9NY61 4 12 273_315 277.3333333333333 561.0 not_retained Region Note=POLR2J binding Hgene AATF chr17:35311207 + TADA2A chr17:35834661 ENST00000225402 Q9NY61 4 12 316_372 277.3333333333333 561.0 not_retained Region Note=RB1 binding Hgene AATF chr17:35311207 + TADA2A chr17:35834661 ENST00000225402 Q9NY61 4 12 373_472 277.3333333333333 561.0 not_retained Region Note=RB1 and SP1 binding Hgene AATF chr17:35311207 + TADA2A chr17:35834661 ENST00000225402 Q9NY61 4 12 96_195 277.3333333333333 561.0 retained Compositional bias Note=Glu-rich Hgene AATF chr17:35311207 + TADA2A chr17:35834661 ENST00000225402 Q9NY61 4 12 2_2 277.3333333333333 561.0 retained Modified residue Note=N-acetylalanine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19413330;Dbxref=PMID:19413330 Hgene AATF chr17:35311207 + TADA2A chr17:35834661 ENST00000225402 Q9NY61 4 12 61_61 277.3333333333333 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35311207 + TADA2A chr17:35834661 ENST00000225402 Q9NY61 4 12 63_63 277.3333333333333 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35311207 + TADA2A chr17:35834661 ENST00000225402 Q9NY61 4 12 150_150 277.3333333333333 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35311207 + TADA2A chr17:35834661 ENST00000225402 Q9NY61 4 12 155_155 277.3333333333333 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35311207 + TADA2A chr17:35834661 ENST00000225402 Q9NY61 4 12 203_203 277.3333333333333 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163 Hgene AATF chr17:35311207 + TADA2A chr17:35834661 ENST00000225402 Q9NY61 4 12 273_273 277.3333333333333 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35311207 + TADA2A chr17:35834661 ENST00000225402 Q9NY61 4 12 316_316 277.3333333333333 561.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692 Hgene AATF chr17:35311207 + TADA2A chr17:35834661 ENST00000225402 Q9NY61 4 12 320_320 277.3333333333333 561.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692 Hgene AATF chr17:35311207 + TADA2A chr17:35834661 ENST00000225402 Q9NY61 4 12 321_321 277.3333333333333 561.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692 Hgene AATF chr17:35311207 + TADA2A chr17:35834661 ENST00000225402 Q9NY61 4 12 2_3 277.3333333333333 561.0 retained Sequence conflict Note=AG->GR;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35311207 + TADA2A chr17:35834661 ENST00000225402 Q9NY61 4 12 4_5 277.3333333333333 561.0 retained Sequence conflict Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35311207 + TADA2A chr17:35834661 ENST00000225402 Q9NY61 4 12 139_139 277.3333333333333 561.0 retained Sequence conflict Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35311207 + TADA2A chr17:35834661 ENST00000225402 Q9NY61 4 12 262_262 277.3333333333333 561.0 retained Sequence conflict Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35311207 + TADA2A chr17:35834661 ENST00000225402 Q9NY61 4 12 272_272 277.3333333333333 561.0 retained Sequence conflict Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35311207 + TADA2A chr17:35834661 ENST00000225402 Q9NY61 4 12 306_306 277.3333333333333 561.0 not_retained Sequence conflict Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35311207 + TADA2A chr17:35834661 ENST00000225402 Q9NY61 4 12 402_402 277.3333333333333 561.0 not_retained Sequence conflict Note=D->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35348156 - GOSR2 chr17:45015965 ENST00000225402 Q9NY61 8 12 1_1 466.0 561.0 retained Initiator methionine Note=Removed;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19413330;Dbxref=PMID:19413330 Hgene AATF chr17:35348156 - GOSR2 chr17:45015965 ENST00000225402 Q9NY61 8 12 2_560 466.0 561.0 not_retained Chain ID=PRO_0000056616;Note=Protein AATF Hgene AATF chr17:35348156 - GOSR2 chr17:45015965 ENST00000225402 Q9NY61 8 12 273_315 466.0 561.0 retained Region Note=POLR2J binding Hgene AATF chr17:35348156 - GOSR2 chr17:45015965 ENST00000225402 Q9NY61 8 12 316_372 466.0 561.0 retained Region Note=RB1 binding Hgene AATF chr17:35348156 - GOSR2 chr17:45015965 ENST00000225402 Q9NY61 8 12 373_472 466.0 561.0 not_retained Region Note=RB1 and SP1 binding Hgene AATF chr17:35348156 - GOSR2 chr17:45015965 ENST00000225402 Q9NY61 8 12 96_195 466.0 561.0 retained Compositional bias Note=Glu-rich Hgene AATF chr17:35348156 - GOSR2 chr17:45015965 ENST00000225402 Q9NY61 8 12 2_2 466.0 561.0 retained Modified residue Note=N-acetylalanine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19413330;Dbxref=PMID:19413330 Hgene AATF chr17:35348156 - GOSR2 chr17:45015965 ENST00000225402 Q9NY61 8 12 61_61 466.0 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35348156 - GOSR2 chr17:45015965 ENST00000225402 Q9NY61 8 12 63_63 466.0 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35348156 - GOSR2 chr17:45015965 ENST00000225402 Q9NY61 8 12 150_150 466.0 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35348156 - GOSR2 chr17:45015965 ENST00000225402 Q9NY61 8 12 155_155 466.0 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35348156 - GOSR2 chr17:45015965 ENST00000225402 Q9NY61 8 12 203_203 466.0 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163 Hgene AATF chr17:35348156 - GOSR2 chr17:45015965 ENST00000225402 Q9NY61 8 12 273_273 466.0 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35348156 - GOSR2 chr17:45015965 ENST00000225402 Q9NY61 8 12 316_316 466.0 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692 Hgene AATF chr17:35348156 - GOSR2 chr17:45015965 ENST00000225402 Q9NY61 8 12 320_320 466.0 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692 Hgene AATF chr17:35348156 - GOSR2 chr17:45015965 ENST00000225402 Q9NY61 8 12 321_321 466.0 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692 Hgene AATF chr17:35348156 - GOSR2 chr17:45015965 ENST00000225402 Q9NY61 8 12 2_3 466.0 561.0 retained Sequence conflict Note=AG->GR;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35348156 - GOSR2 chr17:45015965 ENST00000225402 Q9NY61 8 12 4_5 466.0 561.0 retained Sequence conflict Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35348156 - GOSR2 chr17:45015965 ENST00000225402 Q9NY61 8 12 139_139 466.0 561.0 retained Sequence conflict Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35348156 - GOSR2 chr17:45015965 ENST00000225402 Q9NY61 8 12 262_262 466.0 561.0 retained Sequence conflict Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35348156 - GOSR2 chr17:45015965 ENST00000225402 Q9NY61 8 12 272_272 466.0 561.0 retained Sequence conflict Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35348156 - GOSR2 chr17:45015965 ENST00000225402 Q9NY61 8 12 306_306 466.0 561.0 retained Sequence conflict Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35348156 - GOSR2 chr17:45015965 ENST00000225402 Q9NY61 8 12 402_402 466.0 561.0 retained Sequence conflict Note=D->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35348156 + LIG3 chr17:33325623 ENST00000225402 Q9NY61 8 12 1_1 466.0 561.0 retained Initiator methionine Note=Removed;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19413330;Dbxref=PMID:19413330 Hgene AATF chr17:35348156 + LIG3 chr17:33325623 ENST00000225402 Q9NY61 8 12 2_560 466.0 561.0 not_retained Chain ID=PRO_0000056616;Note=Protein AATF Hgene AATF chr17:35348156 + LIG3 chr17:33325623 ENST00000225402 Q9NY61 8 12 273_315 466.0 561.0 retained Region Note=POLR2J binding Hgene AATF chr17:35348156 + LIG3 chr17:33325623 ENST00000225402 Q9NY61 8 12 316_372 466.0 561.0 retained Region Note=RB1 binding Hgene AATF chr17:35348156 + LIG3 chr17:33325623 ENST00000225402 Q9NY61 8 12 373_472 466.0 561.0 not_retained Region Note=RB1 and SP1 binding Hgene AATF chr17:35348156 + LIG3 chr17:33325623 ENST00000225402 Q9NY61 8 12 96_195 466.0 561.0 retained Compositional bias Note=Glu-rich Hgene AATF chr17:35348156 + LIG3 chr17:33325623 ENST00000225402 Q9NY61 8 12 2_2 466.0 561.0 retained Modified residue Note=N-acetylalanine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19413330;Dbxref=PMID:19413330 Hgene AATF chr17:35348156 + LIG3 chr17:33325623 ENST00000225402 Q9NY61 8 12 61_61 466.0 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35348156 + LIG3 chr17:33325623 ENST00000225402 Q9NY61 8 12 63_63 466.0 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35348156 + LIG3 chr17:33325623 ENST00000225402 Q9NY61 8 12 150_150 466.0 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35348156 + LIG3 chr17:33325623 ENST00000225402 Q9NY61 8 12 155_155 466.0 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35348156 + LIG3 chr17:33325623 ENST00000225402 Q9NY61 8 12 203_203 466.0 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163 Hgene AATF chr17:35348156 + LIG3 chr17:33325623 ENST00000225402 Q9NY61 8 12 273_273 466.0 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Hgene AATF chr17:35348156 + LIG3 chr17:33325623 ENST00000225402 Q9NY61 8 12 316_316 466.0 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692 Hgene AATF chr17:35348156 + LIG3 chr17:33325623 ENST00000225402 Q9NY61 8 12 320_320 466.0 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692 Hgene AATF chr17:35348156 + LIG3 chr17:33325623 ENST00000225402 Q9NY61 8 12 321_321 466.0 561.0 retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692 Hgene AATF chr17:35348156 + LIG3 chr17:33325623 ENST00000225402 Q9NY61 8 12 2_3 466.0 561.0 retained Sequence conflict Note=AG->GR;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35348156 + LIG3 chr17:33325623 ENST00000225402 Q9NY61 8 12 4_5 466.0 561.0 retained Sequence conflict Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35348156 + LIG3 chr17:33325623 ENST00000225402 Q9NY61 8 12 139_139 466.0 561.0 retained Sequence conflict Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35348156 + LIG3 chr17:33325623 ENST00000225402 Q9NY61 8 12 262_262 466.0 561.0 retained Sequence conflict Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35348156 + LIG3 chr17:33325623 ENST00000225402 Q9NY61 8 12 272_272 466.0 561.0 retained Sequence conflict Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35348156 + LIG3 chr17:33325623 ENST00000225402 Q9NY61 8 12 306_306 466.0 561.0 retained Sequence conflict Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene AATF chr17:35348156 + LIG3 chr17:33325623 ENST00000225402 Q9NY61 8 12 402_402 466.0 561.0 retained Sequence conflict Note=D->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1_2595 429.0 2596.0 not_retained Chain ID=PRO_0000093300;Note=ATP-binding cassette sub-family A member 12 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 23_43 429.0 2596.0 retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1065_1085 429.0 2596.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1112_1132 429.0 2596.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1145_1165 429.0 2596.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1174_1194 429.0 2596.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1200_1220 429.0 2596.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1250_1270 429.0 2596.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1747_1767 429.0 2596.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1979_1999 429.0 2596.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 2035_2055 429.0 2596.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 2072_2092 429.0 2596.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 2103_2123 429.0 2596.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 2187_2207 429.0 2596.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 2270_2290 429.0 2596.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1346_1577 429.0 2596.0 not_retained Domain Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 2254_2489 429.0 2596.0 not_retained Domain Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1378_1385 429.0 2596.0 not_retained Nucleotide binding Note=ATP 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 2290_2297 429.0 2596.0 not_retained Nucleotide binding Note=ATP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 156_156 429.0 2596.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 174_174 429.0 2596.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 214_214 429.0 2596.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 275_275 429.0 2596.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 333_333 429.0 2596.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 367_367 429.0 2596.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 383_383 429.0 2596.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 412_412 429.0 2596.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 435_435 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 528_528 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 543_543 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 577_577 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 608_608 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 623_623 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 648_648 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 752_752 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 826_826 429.0 2596.0 not_retained Sequence conflict Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 920_920 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 963_963 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1170_1170 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1524_1524 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1663_1663 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1704_1704 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1769_1769 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1819_1819 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1835_1835 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1876_1876 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1921_1921 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1952_1952 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 2178_2178 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 2208_2208 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 2223_2223 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 2318_2318 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 2542_2542 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 2547_2547 429.0 2596.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1_318 429.0 2596.0 retained Alternative sequence ID=VSP_011283;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 319_328 429.0 2596.0 retained Alternative sequence ID=VSP_011284;Note=In isoform 2. LLYTLDSPAQ->MFTYIKIITS;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 199_199 429.0 2596.0 retained Natural variant ID=VAR_055473;Note=W->C;Dbxref=dbSNP:rs16853238 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 237_237 429.0 2596.0 retained Natural variant ID=VAR_055474;Note=N->H;Dbxref=dbSNP:rs11890512 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 274_274 429.0 2596.0 retained Natural variant ID=VAR_055475;Note=Q->R;Dbxref=dbSNP:rs11890468 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 287_287 429.0 2596.0 retained Natural variant ID=VAR_055476;Note=R->G;Dbxref=dbSNP:rs11891778 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 345_345 429.0 2596.0 retained Natural variant ID=VAR_067075;Note=In ARCI4A%3B skin phenotype consistent with non-bullous congenital ichthyosiform erythroderma. T->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17508018;Dbxref=dbSNP:rs1295935868,PMID:17508018 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 387_387 429.0 2596.0 retained Natural variant ID=VAR_067076;Note=In ARCI4B. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16675967;Dbxref=dbSNP:rs746315995,PMID:16675967 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 459_459 429.0 2596.0 not_retained Natural variant ID=VAR_019597;Note=S->T;Dbxref=dbSNP:rs113112835 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 476_476 429.0 2596.0 not_retained Natural variant ID=VAR_062663;Note=In a pancreatic ductal adenocarcinoma sample%3B somatic mutation. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18772397;Dbxref=dbSNP:rs370640837,PMID:18772397 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 550_550 429.0 2596.0 not_retained Natural variant ID=VAR_027444;Note=E->G;Dbxref=dbSNP:rs16853149 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 777_777 429.0 2596.0 not_retained Natural variant ID=VAR_027445;Note=S->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12697999,ECO:0000269|Ref.2,ECO:0000269|Ref.4;Dbxref=dbSNP:rs7560008,PMID:12697999 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1136_1136 429.0 2596.0 not_retained Natural variant ID=VAR_067077;Note=In ARCI4A%3B skin phenotype consistent with non-bullous congenital ichthyosiform erythroderma. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18284401;Dbxref=PMID:18284401 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1179_1179 429.0 2596.0 not_retained Natural variant ID=VAR_067078;Note=In ARCI4B. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16902423;Dbxref=dbSNP:rs267606622,PMID:16902423 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1235_1235 429.0 2596.0 not_retained Natural variant ID=VAR_067079;Note=In ARCI4A%3B skin phenotype consistent with non-bullous congenital ichthyosiform erythroderma. W->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19262603;Dbxref=PMID:19262603 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1251_1251 429.0 2596.0 not_retained Natural variant ID=VAR_027446;Note=G->D;Dbxref=dbSNP:rs13414448 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1380_1380 429.0 2596.0 not_retained Natural variant ID=VAR_019598;Note=In ARCI4A. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12915478;Dbxref=dbSNP:rs28940269,PMID:12915478 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1381_1381 429.0 2596.0 not_retained Natural variant ID=VAR_019599;Note=In ARCI4A. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12915478;Dbxref=dbSNP:rs28940268,PMID:12915478 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1494_1494 429.0 2596.0 not_retained Natural variant ID=VAR_067080;Note=In ARCI4A%3B skin phenotype consistent with non-bullous congenital ichthyosiform erythroderma. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17508018;Dbxref=dbSNP:rs1263698595,PMID:17508018 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1514_1514 429.0 2596.0 not_retained Natural variant ID=VAR_019600;Note=In ARCI4A. R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12915478,ECO:0000269|PubMed:19262603;Dbxref=dbSNP:rs28940270,PMID:12915478,PMID:19262603 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1539_1539 429.0 2596.0 not_retained Natural variant ID=VAR_019601;Note=In ARCI4A. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12915478;Dbxref=dbSNP:rs28940271,PMID:12915478 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1546_1546 429.0 2596.0 not_retained Natural variant ID=VAR_027447;Note=R->C;Dbxref=dbSNP:rs13401480 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1559_1559 429.0 2596.0 not_retained Natural variant ID=VAR_067081;Note=In ARCI4A%3B skin phenotype consistent with non-bullous congenital ichthyosiform erythroderma. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22257947;Dbxref=dbSNP:rs1457513156,PMID:22257947 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1651_1651 429.0 2596.0 not_retained Natural variant ID=VAR_019602;Note=In ARCI4A. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12915478;Dbxref=dbSNP:rs28940568,PMID:12915478 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1798_1798 429.0 2596.0 not_retained Natural variant ID=VAR_067082;Note=In ARCI4A%3B skin phenotype consistent with non-bullous congenital ichthyosiform erythroderma. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19262603;Dbxref=dbSNP:rs181314573,PMID:19262603 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 1980_1980 429.0 2596.0 not_retained Natural variant ID=VAR_067083;Note=In ARCI4A%3B skin phenotype consistent with non-bullous congenital ichthyosiform erythroderma. T->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19262603;Dbxref=dbSNP:rs763858530,PMID:19262603 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 2064_2064 429.0 2596.0 not_retained Natural variant ID=VAR_027448;Note=E->K;Dbxref=dbSNP:rs1213011 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 2365_2365 429.0 2596.0 not_retained Natural variant ID=VAR_027449;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15756637;Dbxref=dbSNP:rs726070,PMID:15756637 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 651_651 429.0 2596.0 not_retained Sequence conflict Note=Y->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 811_811 429.0 2596.0 not_retained Sequence conflict Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 826_826 429.0 2596.0 not_retained Sequence conflict Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000272895 Q86UK0 11 53 2079_2079 429.0 2596.0 not_retained Sequence conflict Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1_2595 111.0 2278.0 not_retained Chain ID=PRO_0000093300;Note=ATP-binding cassette sub-family A member 12 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 23_43 111.0 2278.0 retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1065_1085 111.0 2278.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1112_1132 111.0 2278.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1145_1165 111.0 2278.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1174_1194 111.0 2278.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1200_1220 111.0 2278.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1250_1270 111.0 2278.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1747_1767 111.0 2278.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1979_1999 111.0 2278.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 2035_2055 111.0 2278.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 2072_2092 111.0 2278.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 2103_2123 111.0 2278.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 2187_2207 111.0 2278.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 2270_2290 111.0 2278.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1346_1577 111.0 2278.0 not_retained Domain Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 2254_2489 111.0 2278.0 not_retained Domain Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1378_1385 111.0 2278.0 not_retained Nucleotide binding Note=ATP 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 2290_2297 111.0 2278.0 not_retained Nucleotide binding Note=ATP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 156_156 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 174_174 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 214_214 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 275_275 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 333_333 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 367_367 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 383_383 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 412_412 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 435_435 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 528_528 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 543_543 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 577_577 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 608_608 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 623_623 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 648_648 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 752_752 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 826_826 111.0 2278.0 not_retained Sequence conflict Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 920_920 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 963_963 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1170_1170 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1524_1524 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1663_1663 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1704_1704 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1769_1769 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1819_1819 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1835_1835 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1876_1876 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1921_1921 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1952_1952 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 2178_2178 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 2208_2208 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 2223_2223 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 2318_2318 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 2542_2542 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 2547_2547 111.0 2278.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1_318 111.0 2278.0 not_retained Alternative sequence ID=VSP_011283;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 319_328 111.0 2278.0 not_retained Alternative sequence ID=VSP_011284;Note=In isoform 2. LLYTLDSPAQ->MFTYIKIITS;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 199_199 111.0 2278.0 not_retained Natural variant ID=VAR_055473;Note=W->C;Dbxref=dbSNP:rs16853238 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 237_237 111.0 2278.0 not_retained Natural variant ID=VAR_055474;Note=N->H;Dbxref=dbSNP:rs11890512 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 274_274 111.0 2278.0 not_retained Natural variant ID=VAR_055475;Note=Q->R;Dbxref=dbSNP:rs11890468 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 287_287 111.0 2278.0 not_retained Natural variant ID=VAR_055476;Note=R->G;Dbxref=dbSNP:rs11891778 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 345_345 111.0 2278.0 not_retained Natural variant ID=VAR_067075;Note=In ARCI4A%3B skin phenotype consistent with non-bullous congenital ichthyosiform erythroderma. T->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17508018;Dbxref=dbSNP:rs1295935868,PMID:17508018 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 387_387 111.0 2278.0 not_retained Natural variant ID=VAR_067076;Note=In ARCI4B. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16675967;Dbxref=dbSNP:rs746315995,PMID:16675967 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 459_459 111.0 2278.0 not_retained Natural variant ID=VAR_019597;Note=S->T;Dbxref=dbSNP:rs113112835 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 476_476 111.0 2278.0 not_retained Natural variant ID=VAR_062663;Note=In a pancreatic ductal adenocarcinoma sample%3B somatic mutation. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18772397;Dbxref=dbSNP:rs370640837,PMID:18772397 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 550_550 111.0 2278.0 not_retained Natural variant ID=VAR_027444;Note=E->G;Dbxref=dbSNP:rs16853149 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 777_777 111.0 2278.0 not_retained Natural variant ID=VAR_027445;Note=S->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12697999,ECO:0000269|Ref.2,ECO:0000269|Ref.4;Dbxref=dbSNP:rs7560008,PMID:12697999 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1136_1136 111.0 2278.0 not_retained Natural variant ID=VAR_067077;Note=In ARCI4A%3B skin phenotype consistent with non-bullous congenital ichthyosiform erythroderma. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18284401;Dbxref=PMID:18284401 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1179_1179 111.0 2278.0 not_retained Natural variant ID=VAR_067078;Note=In ARCI4B. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16902423;Dbxref=dbSNP:rs267606622,PMID:16902423 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1235_1235 111.0 2278.0 not_retained Natural variant ID=VAR_067079;Note=In ARCI4A%3B skin phenotype consistent with non-bullous congenital ichthyosiform erythroderma. W->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19262603;Dbxref=PMID:19262603 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1251_1251 111.0 2278.0 not_retained Natural variant ID=VAR_027446;Note=G->D;Dbxref=dbSNP:rs13414448 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1380_1380 111.0 2278.0 not_retained Natural variant ID=VAR_019598;Note=In ARCI4A. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12915478;Dbxref=dbSNP:rs28940269,PMID:12915478 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1381_1381 111.0 2278.0 not_retained Natural variant ID=VAR_019599;Note=In ARCI4A. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12915478;Dbxref=dbSNP:rs28940268,PMID:12915478 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1494_1494 111.0 2278.0 not_retained Natural variant ID=VAR_067080;Note=In ARCI4A%3B skin phenotype consistent with non-bullous congenital ichthyosiform erythroderma. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17508018;Dbxref=dbSNP:rs1263698595,PMID:17508018 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1514_1514 111.0 2278.0 not_retained Natural variant ID=VAR_019600;Note=In ARCI4A. R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12915478,ECO:0000269|PubMed:19262603;Dbxref=dbSNP:rs28940270,PMID:12915478,PMID:19262603 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1539_1539 111.0 2278.0 not_retained Natural variant ID=VAR_019601;Note=In ARCI4A. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12915478;Dbxref=dbSNP:rs28940271,PMID:12915478 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1546_1546 111.0 2278.0 not_retained Natural variant ID=VAR_027447;Note=R->C;Dbxref=dbSNP:rs13401480 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1559_1559 111.0 2278.0 not_retained Natural variant ID=VAR_067081;Note=In ARCI4A%3B skin phenotype consistent with non-bullous congenital ichthyosiform erythroderma. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22257947;Dbxref=dbSNP:rs1457513156,PMID:22257947 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1651_1651 111.0 2278.0 not_retained Natural variant ID=VAR_019602;Note=In ARCI4A. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12915478;Dbxref=dbSNP:rs28940568,PMID:12915478 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1798_1798 111.0 2278.0 not_retained Natural variant ID=VAR_067082;Note=In ARCI4A%3B skin phenotype consistent with non-bullous congenital ichthyosiform erythroderma. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19262603;Dbxref=dbSNP:rs181314573,PMID:19262603 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 1980_1980 111.0 2278.0 not_retained Natural variant ID=VAR_067083;Note=In ARCI4A%3B skin phenotype consistent with non-bullous congenital ichthyosiform erythroderma. T->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19262603;Dbxref=dbSNP:rs763858530,PMID:19262603 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 2064_2064 111.0 2278.0 not_retained Natural variant ID=VAR_027448;Note=E->K;Dbxref=dbSNP:rs1213011 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 2365_2365 111.0 2278.0 not_retained Natural variant ID=VAR_027449;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15756637;Dbxref=dbSNP:rs726070,PMID:15756637 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 651_651 111.0 2278.0 not_retained Sequence conflict Note=Y->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 811_811 111.0 2278.0 not_retained Sequence conflict Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 826_826 111.0 2278.0 not_retained Sequence conflict Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene ABCA12 chr2:215890397 - SGPP2 chr2:223339287 ENST00000389661 Q86UK0 3 45 2079_2079 111.0 2278.0 not_retained Sequence conflict Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1_2261 140.33333333333334 2262.0 not_retained Chain ID=PRO_0000093288;Note=Phospholipid-transporting ATPase ABCA1 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 22_42 140.33333333333334 2262.0 retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 43_639 140.33333333333334 2262.0 not_retained Topological domain Note=Extracellular Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 640_660 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 683_703 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 716_736 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 745_765 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 777_797 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 827_847 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1041_1057 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1351_1371 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1372_1656 140.33333333333334 2262.0 not_retained Topological domain Note=Extracellular Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1657_1677 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1703_1723 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1735_1755 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1768_1788 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1802_1822 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1852_1872 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 899_1131 140.33333333333334 2262.0 not_retained Domain Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1912_2144 140.33333333333334 2262.0 not_retained Domain Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 933_940 140.33333333333334 2262.0 not_retained Nucleotide binding Note=ATP 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1946_1953 140.33333333333334 2262.0 not_retained Nucleotide binding Note=ATP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1042_1042 140.33333333333334 2262.0 not_retained Modified residue Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12196520;Dbxref=PMID:12196520 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1296_1296 140.33333333333334 2262.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41233 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 2054_2054 140.33333333333334 2262.0 not_retained Modified residue Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12196520;Dbxref=PMID:12196520 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 3_3 140.33333333333334 2262.0 retained Mutagenesis Note=Mild decrease of palmitoylation. Loss of localization to plasma membrane. Decreased cholesterol efflux. Decreased phospholipid efflux. Decreased palmitoylation%3B when associated with S-23%2C S-1110 and S-1111. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 23_23 140.33333333333334 2262.0 retained Mutagenesis Note=Mild decrease of palmitoylation. Loss of localization to plasma membrane. Decreased palmitoylation%3B when associated with S-3%2C S-1110 and S-1111. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1110_1110 140.33333333333334 2262.0 not_retained Mutagenesis Note=Decreased palmitoylation%3B when associated with S-3%2C S-23 and S-1111. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1111_1111 140.33333333333334 2262.0 not_retained Mutagenesis Note=Decreased palmitoylation%3B when associated with S-3%2C S-23 and S-1110. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 14_14 140.33333333333334 2262.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 98_98 140.33333333333334 2262.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 151_151 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 161_161 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 196_196 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 244_244 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 292_292 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 337_337 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 349_349 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 400_400 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 478_478 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 489_489 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 521_521 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 820_820 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1144_1144 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1294_1294 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1453_1453 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1504_1504 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1637_1637 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 2044_2044 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 2238_2238 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 75_309 140.33333333333334 2262.0 not_retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19258317;Dbxref=PMID:19258317 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1463_1477 140.33333333333334 2262.0 not_retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19258317;Dbxref=PMID:19258317 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 85_85 140.33333333333334 2262.0 retained Natural variant ID=VAR_017529;Note=In FHA1%3B Alabama. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12204794;Dbxref=dbSNP:rs145183203,PMID:12204794 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 210_210 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_035724;Note=In a colorectal cancer sample%3B somatic mutation. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 219_219 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012618;Note=Associated with a decreased severity of CAD. R->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10938021,ECO:0000269|PubMed:11238261,ECO:0000269|PubMed:11257261,ECO:0000269|PubMed:11476965,ECO:0000269|PubMed:12624133,ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs2230806,PMID:10938021,PMID:11238261,PMID:11257261,PMID:11476965,PMID:12624133,PMID:12966036,PMID:15520867 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 230_230 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012619;Note=R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10938021,ECO:0000269|PubMed:27535533;Dbxref=dbSNP:rs9282541,PMID:10938021,PMID:27535533 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 248_248 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062481;Note=P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs142625938,PMID:15297675 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 255_255 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012620;Note=In TGD%3B deficient cellular cholesterol efflux. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11785958;Dbxref=dbSNP:rs758100110,PMID:11785958 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 284_284 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062482;Note=In TGD. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15019541;Dbxref=PMID:15019541 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 364_364 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062483;Note=S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs775035559,PMID:15520867 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 399_399 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009145;Note=V->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431237,ECO:0000269|PubMed:11238261;Dbxref=dbSNP:rs9282543,PMID:10431237,PMID:11238261 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 401_401 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062484;Note=K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs138487227,PMID:15297675 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 482_482 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062485;Note=In TGD. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15019541;Dbxref=PMID:15019541 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 496_496 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062486;Note=Associated with increased plasma HDL cholesterol. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs147675550,PMID:15297675 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 587_587 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009146;Note=In TGD. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11257260;Dbxref=dbSNP:rs2853574,PMID:11257260 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 590_590 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009147;Note=In TGD%3B moderately decreased protein abundance%3B highly decreased ATPase activity%3B highly decreased phospholipid translocase activity. W->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431237,ECO:0000269|PubMed:15297675,ECO:0000269|PubMed:24097981;Dbxref=dbSNP:rs137854496,PMID:10431237,PMID:15297675,PMID:24097981 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 590_590 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009147;Note=In TGD%3B moderately decreased protein abundance%3B highly decreased ATPase activity%3B highly decreased phospholipid translocase activity. W->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431237,ECO:0000269|PubMed:15297675,ECO:0000269|PubMed:24097981;Dbxref=dbSNP:rs137854496,PMID:10431237,PMID:15297675,PMID:24097981 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 597_597 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009148;Note=In TGD. Q->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431236,ECO:0000269|PubMed:11086027;Dbxref=dbSNP:rs2853578,PMID:10431236,PMID:11086027 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 638_638 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062488;Note=Associated with reduced plasma HDL cholesterol. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs374190304,PMID:15297675 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 693_693 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009149;Note=In FHA1. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431236,ECO:0000269|PubMed:11086027;Dbxref=PMID:10431236,PMID:11086027 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 771_771 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012621;Note=Associated with HDL cholesterol. V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11238261,ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:15262183,ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs2066718,PMID:11238261,PMID:12966036,PMID:15262183,PMID:15520867 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 774_774 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062489;Note=T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=PMID:15297675 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 774_774 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062489;Note=T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=PMID:15297675 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 776_776 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012623;Note=May be associated with increased risk of ischemic heart disease. K->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11238261,ECO:0000269|PubMed:15520867,ECO:0000269|PubMed:16226177;Dbxref=dbSNP:rs138880920,PMID:11238261,PMID:15520867,PMID:16226177 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 815_815 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062490;Note=Associated with reduced plasma HDL cholesterol. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs145582736,PMID:15297675 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 825_825 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012624;Note=Associated with higher plasma cholesterol. V->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10938021,ECO:0000269|PubMed:11238261,ECO:0000269|PubMed:12709788,ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs2066715,PMID:10938021,PMID:11238261,PMID:12709788,PMID:12966036,PMID:15520867 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 840_840 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062491;Note=In TGD. W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15262183;Dbxref=dbSNP:rs1322998567,PMID:15262183 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 883_883 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012625;Note=Associated with higher plasma cholesterol. I->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431237,ECO:0000269|PubMed:10938021,ECO:0000269|PubMed:11238261,ECO:0000269|PubMed:11257261,ECO:0000269|PubMed:12709788,ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs2066714,PMID:10431237,PMID:10938021,PMID:11238261,PMID:11257261,PMID:12709788,PMID:12966036,PMID:15520867 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 917_917 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_035725;Note=In a colorectal cancer sample%3B somatic mutation. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 929_929 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012626;Note=In TGD%3B moderately decreased protein abundance%3B highly decreased ATPase activity%3B highly decreased phospholipid translocase activity%3B loss protein subcellular localization to the plasma membrane. T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11086027,ECO:0000269|PubMed:24097981;Dbxref=PMID:11086027,PMID:24097981 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 935_935 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009150;Note=In TGD%3B moderately decreased protein abundance%3B highly decreased ATPase activity%3B highly decreased phospholipid translocase activity. N->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431237,ECO:0000269|PubMed:12111381,ECO:0000269|PubMed:24097981;Dbxref=dbSNP:rs28937313,PMID:10431237,PMID:12111381,PMID:24097981 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 935_935 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009150;Note=In TGD%3B moderately decreased protein abundance%3B highly decreased ATPase activity%3B highly decreased phospholipid translocase activity. N->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431237,ECO:0000269|PubMed:12111381,ECO:0000269|PubMed:24097981;Dbxref=dbSNP:rs28937313,PMID:10431237,PMID:12111381,PMID:24097981 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 937_937 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009151;Note=In TGD. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10431237;Dbxref=dbSNP:rs137854495,PMID:10431237 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1046_1046 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012627;Note=In TGD. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10938021;Dbxref=dbSNP:rs141021096,PMID:10938021 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1054_1054 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_037969;Note=V->I;Dbxref=dbSNP:rs13306072 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1065_1065 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062492;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15520867;Dbxref=PMID:15520867 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1068_1068 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062493;Note=In TGD. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15262183;Dbxref=dbSNP:rs745593394,PMID:15262183 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1091_1091 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012628;Note=In FHA1%3B loss of localization to plasma membrane%3B decreased cholesterol efflux%3B decreased phospholipid efflux. M->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10533863,ECO:0000269|PubMed:11086027,ECO:0000269|PubMed:19556522;Dbxref=PMID:10533863,PMID:11086027,PMID:19556522 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1099_1099 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_017530;Note=In FHA1. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12009425;Dbxref=dbSNP:rs28933692,PMID:12009425 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1172_1172 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012629;Note=Associated with premature coronary heart disease. E->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11238261,ECO:0000269|PubMed:11257261,ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs33918808,PMID:11238261,PMID:11257261,PMID:12966036,PMID:15520867 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1181_1181 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_017016;Note=Associated with reduced plasma HDL cholesterol. S->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs76881554,PMID:12966036,PMID:15297675 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1216_1216 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062494;Note=G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs562403512,PMID:15520867 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1289_1289 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009152;Note=In TGD. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10706591,ECO:0000269|PubMed:11476965;Dbxref=dbSNP:rs137854500,PMID:10706591,PMID:11476965 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1341_1341 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062495;Note=Associated with reduced plasma HDL cholesterol. R->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs147743782,PMID:15297675 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1376_1376 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062496;Note=S->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs145689805,PMID:15297675 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1379_1379 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062497;Note=In TGD%3B the mutant protein is retained in the endoplasmic reticulum while the wild-type protein is located at the plasma membrane. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15158913;Dbxref=PMID:15158913 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1407_1407 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_035726;Note=In a colorectal cancer sample%3B somatic mutation. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs189206655,PMID:16959974 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1477_1477 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009153;Note=In TGD%3B loss of interaction with APOE%3B unable to generate APOE-containing high density lipoproteins%3B moderately decreased protein abundance%3B moderately decreased ATPase activity%3B moderately decreased phospholipid translocase activity. C->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431236,ECO:0000269|PubMed:11086027,ECO:0000269|PubMed:14754908,ECO:0000269|PubMed:24097981;Dbxref=dbSNP:rs137854494,PMID:10431236,PMID:11086027,PMID:14754908,PMID:24097981 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1506_1506 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012630;Note=In TGD. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11476961;Dbxref=dbSNP:rs137854497,PMID:11476961 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1517_1517 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009154;Note=In TGD. I->R Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1555_1555 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012638;Note=I->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092505,ECO:0000269|PubMed:10431238;Dbxref=dbSNP:rs1997618,PMID:10092505,PMID:10431238 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1587_1587 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012631;Note=Associated with HDL cholesterol. K->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092505,ECO:0000269|PubMed:10431238,ECO:0000269|PubMed:10884428,ECO:0000269|PubMed:10938021,ECO:0000269|PubMed:11238261,ECO:0000269|PubMed:11352567,ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:15520867,ECO:0000269|Ref.2;Dbxref=dbSNP:rs2230808,PMID:10092505,PMID:10431238,PMID:10884428,PMID:10938021,PMID:11238261,PMID:11352567,PMID:12966036,PMID:15520867 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1611_1611 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012632;Note=Probable disease-associated variant%3B associated with atherosclerosis%3B deficient cellular cholesterol efflux. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11785958;Dbxref=PMID:11785958 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1615_1615 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062498;Note=Associated with reduced plasma HDL cholesterol. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs1251839800,PMID:15297675 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1648_1648 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012639;Note=L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092505,ECO:0000269|PubMed:10431238;Dbxref=dbSNP:rs1883024,PMID:10092505,PMID:10431238 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1670_1670 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062499;Note=Associated with reduced plasma HDL cholesterol. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs1203589782,PMID:15297675 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1680_1680 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_037970;Note=In TGD. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12111371;Dbxref=dbSNP:rs137854498,PMID:12111371 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1680_1680 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_037970;Note=In TGD. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12111371;Dbxref=dbSNP:rs137854498,PMID:12111371 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1704_1704 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062501;Note=In TGD%3B the mutant protein is retained in the endoplasmic reticulum while the wild-type protein is located at the plasma membrane. V->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15158913;Dbxref=PMID:15158913 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1731_1731 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012633;Note=S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11238261;Dbxref=dbSNP:rs760507032,PMID:11238261 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1800_1800 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009155;Note=In TGD. N->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10706591,ECO:0000269|PubMed:15019541,ECO:0000269|PubMed:15297675,ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs146292819,PMID:10706591,PMID:15019541,PMID:15297675,PMID:15520867 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1851_1851 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062502;Note=In TGD. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14576201;Dbxref=dbSNP:rs1055285452,PMID:14576201 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1893_1894 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012634;Note=In FHA1. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10533863,ECO:0000269|PubMed:11086027;Dbxref=PMID:10533863,PMID:11086027 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1897_1897 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062503;Note=In FHA1%3B uncertain pathological significance. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15722566;Dbxref=dbSNP:rs760768125,PMID:15722566 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1901_1901 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062504;Note=In TGD. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15019541;Dbxref=PMID:15019541 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1925_1925 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062505;Note=In Scott syndrome%3B shows impaired trafficking of the mutant protein to the plasma membrane. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15790791;Dbxref=dbSNP:rs142688906,PMID:15790791 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 2009_2009 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_037971;Note=In FHA1. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12009425;Dbxref=dbSNP:rs137854499,PMID:12009425 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 2081_2081 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012635;Note=In TGD%3B highly decreased protein abundance%3B highly decreased ATPase activity%3B highly decreased phospholipid translocase activity%3B loss protein subcellular localization to the plasma membrane. R->W;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11476965,ECO:0000269|PubMed:24097981;Dbxref=dbSNP:rs137854501,PMID:11476965,PMID:24097981 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 2109_2109 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_035727;Note=In a colorectal cancer sample%3B somatic mutation. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 2150_2150 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012636;Note=In FHA1%3B moderately decreased protein abundance%3B does not affect ATPase activity%3B moderately decreased phospholipid translocase activity. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11086027,ECO:0000269|PubMed:24097981;Dbxref=dbSNP:rs369098049,PMID:11086027,PMID:24097981 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 2163_2163 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062506;Note=Could be associated with reduced plasma HDL cholesterol. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15262183;Dbxref=PMID:15262183 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 2168_2168 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012637;Note=L->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092505,ECO:0000269|PubMed:10431238,ECO:0000269|PubMed:11257260;Dbxref=dbSNP:rs2853577,PMID:10092505,PMID:10431238,PMID:11257260 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 2196_2196 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062507;Note=In TGD. Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15019541;Dbxref=dbSNP:rs564764153,PMID:15019541 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 2243_2243 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062508;Note=D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs34879708,PMID:15297675 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 2244_2244 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062509;Note=Could be associated with reduced plasma HDL cholesterol. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15262183;Dbxref=dbSNP:rs144588452,PMID:15262183 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 3_3 140.33333333333334 2262.0 retained Mutagenesis Note=Mild decrease of palmitoylation. Loss of localization to plasma membrane. Decreased cholesterol efflux. Decreased phospholipid efflux. Decreased palmitoylation%3B when associated with S-23%2C S-1110 and S-1111. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 23_23 140.33333333333334 2262.0 retained Mutagenesis Note=Mild decrease of palmitoylation. Loss of localization to plasma membrane. Decreased palmitoylation%3B when associated with S-3%2C S-1110 and S-1111. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 100_100 140.33333333333334 2262.0 retained Mutagenesis Note=Highly decreased protein abundance. Highly decreased ATPase activity. Highly decreased phospholipid translocase activity. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24097981;Dbxref=PMID:24097981 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 593_593 140.33333333333334 2262.0 not_retained Mutagenesis Note=Moderately decreased protein abundance. Highly decreased ATPase activity. Highly decreased phospholipid translocase activity. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24097981;Dbxref=PMID:24097981 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 939_939 140.33333333333334 2262.0 not_retained Mutagenesis Note=Inhibits ATPase activity%3B when associated with M-1952. Decreases translocase activity%3B when associated with M-1952. Does not affect protein subcellular localization in plasma membrane and endosome%3B when associated with M-1952. K->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24097981;Dbxref=PMID:24097981 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1110_1110 140.33333333333334 2262.0 not_retained Mutagenesis Note=Decreased palmitoylation%3B when associated with S-3%2C S-23 and S-1111. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1111_1111 140.33333333333334 2262.0 not_retained Mutagenesis Note=Decreased palmitoylation%3B when associated with S-3%2C S-23 and S-1110. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1512_1512 140.33333333333334 2262.0 not_retained Mutagenesis Note=Moderately decreased protein abundance. Does not affect ATPase activity. Moderately decreased phospholipid translocase activity. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24097981;Dbxref=PMID:24097981 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1952_1952 140.33333333333334 2262.0 not_retained Mutagenesis Note=Inhibits ATPase activity%3B when associated with M-939. Decreases translocase activity%3B when associated with M-939. Does not affect protein subcellular localization in plasma membrane and endosome%3B when associated with M-939. K->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24097981;Dbxref=PMID:24097981 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 793_793 140.33333333333334 2262.0 not_retained Sequence conflict Note=Y->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 831_831 140.33333333333334 2262.0 not_retained Sequence conflict Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1005_1005 140.33333333333334 2262.0 not_retained Sequence conflict Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene ABCA1 chr9:107645320 - RAB5C chr17:40278866 ENST00000374736 O95477 5 50 1745_1746 140.33333333333334 2262.0 not_retained Sequence conflict Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1_2261 140.33333333333334 2262.0 not_retained Chain ID=PRO_0000093288;Note=Phospholipid-transporting ATPase ABCA1 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 22_42 140.33333333333334 2262.0 retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 43_639 140.33333333333334 2262.0 not_retained Topological domain Note=Extracellular Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 640_660 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 683_703 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 716_736 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 745_765 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 777_797 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 827_847 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1041_1057 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1351_1371 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1372_1656 140.33333333333334 2262.0 not_retained Topological domain Note=Extracellular Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1657_1677 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1703_1723 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1735_1755 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1768_1788 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1802_1822 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1852_1872 140.33333333333334 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 899_1131 140.33333333333334 2262.0 not_retained Domain Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1912_2144 140.33333333333334 2262.0 not_retained Domain Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 933_940 140.33333333333334 2262.0 not_retained Nucleotide binding Note=ATP 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1946_1953 140.33333333333334 2262.0 not_retained Nucleotide binding Note=ATP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1042_1042 140.33333333333334 2262.0 not_retained Modified residue Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12196520;Dbxref=PMID:12196520 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1296_1296 140.33333333333334 2262.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41233 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 2054_2054 140.33333333333334 2262.0 not_retained Modified residue Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12196520;Dbxref=PMID:12196520 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 3_3 140.33333333333334 2262.0 retained Mutagenesis Note=Mild decrease of palmitoylation. Loss of localization to plasma membrane. Decreased cholesterol efflux. Decreased phospholipid efflux. Decreased palmitoylation%3B when associated with S-23%2C S-1110 and S-1111. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 23_23 140.33333333333334 2262.0 retained Mutagenesis Note=Mild decrease of palmitoylation. Loss of localization to plasma membrane. Decreased palmitoylation%3B when associated with S-3%2C S-1110 and S-1111. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1110_1110 140.33333333333334 2262.0 not_retained Mutagenesis Note=Decreased palmitoylation%3B when associated with S-3%2C S-23 and S-1111. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1111_1111 140.33333333333334 2262.0 not_retained Mutagenesis Note=Decreased palmitoylation%3B when associated with S-3%2C S-23 and S-1110. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 14_14 140.33333333333334 2262.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 98_98 140.33333333333334 2262.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 151_151 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 161_161 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 196_196 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 244_244 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 292_292 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 337_337 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 349_349 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 400_400 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 478_478 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 489_489 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 521_521 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 820_820 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1144_1144 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1294_1294 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1453_1453 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1504_1504 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1637_1637 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 2044_2044 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 2238_2238 140.33333333333334 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 75_309 140.33333333333334 2262.0 not_retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19258317;Dbxref=PMID:19258317 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1463_1477 140.33333333333334 2262.0 not_retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19258317;Dbxref=PMID:19258317 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 85_85 140.33333333333334 2262.0 retained Natural variant ID=VAR_017529;Note=In FHA1%3B Alabama. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12204794;Dbxref=dbSNP:rs145183203,PMID:12204794 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 210_210 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_035724;Note=In a colorectal cancer sample%3B somatic mutation. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 219_219 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012618;Note=Associated with a decreased severity of CAD. R->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10938021,ECO:0000269|PubMed:11238261,ECO:0000269|PubMed:11257261,ECO:0000269|PubMed:11476965,ECO:0000269|PubMed:12624133,ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs2230806,PMID:10938021,PMID:11238261,PMID:11257261,PMID:11476965,PMID:12624133,PMID:12966036,PMID:15520867 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 230_230 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012619;Note=R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10938021,ECO:0000269|PubMed:27535533;Dbxref=dbSNP:rs9282541,PMID:10938021,PMID:27535533 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 248_248 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062481;Note=P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs142625938,PMID:15297675 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 255_255 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012620;Note=In TGD%3B deficient cellular cholesterol efflux. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11785958;Dbxref=dbSNP:rs758100110,PMID:11785958 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 284_284 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062482;Note=In TGD. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15019541;Dbxref=PMID:15019541 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 364_364 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062483;Note=S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs775035559,PMID:15520867 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 399_399 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009145;Note=V->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431237,ECO:0000269|PubMed:11238261;Dbxref=dbSNP:rs9282543,PMID:10431237,PMID:11238261 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 401_401 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062484;Note=K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs138487227,PMID:15297675 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 482_482 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062485;Note=In TGD. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15019541;Dbxref=PMID:15019541 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 496_496 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062486;Note=Associated with increased plasma HDL cholesterol. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs147675550,PMID:15297675 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 587_587 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009146;Note=In TGD. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11257260;Dbxref=dbSNP:rs2853574,PMID:11257260 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 590_590 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009147;Note=In TGD%3B moderately decreased protein abundance%3B highly decreased ATPase activity%3B highly decreased phospholipid translocase activity. W->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431237,ECO:0000269|PubMed:15297675,ECO:0000269|PubMed:24097981;Dbxref=dbSNP:rs137854496,PMID:10431237,PMID:15297675,PMID:24097981 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 590_590 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009147;Note=In TGD%3B moderately decreased protein abundance%3B highly decreased ATPase activity%3B highly decreased phospholipid translocase activity. W->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431237,ECO:0000269|PubMed:15297675,ECO:0000269|PubMed:24097981;Dbxref=dbSNP:rs137854496,PMID:10431237,PMID:15297675,PMID:24097981 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 597_597 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009148;Note=In TGD. Q->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431236,ECO:0000269|PubMed:11086027;Dbxref=dbSNP:rs2853578,PMID:10431236,PMID:11086027 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 638_638 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062488;Note=Associated with reduced plasma HDL cholesterol. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs374190304,PMID:15297675 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 693_693 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009149;Note=In FHA1. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431236,ECO:0000269|PubMed:11086027;Dbxref=PMID:10431236,PMID:11086027 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 771_771 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012621;Note=Associated with HDL cholesterol. V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11238261,ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:15262183,ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs2066718,PMID:11238261,PMID:12966036,PMID:15262183,PMID:15520867 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 774_774 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062489;Note=T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=PMID:15297675 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 774_774 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062489;Note=T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=PMID:15297675 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 776_776 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012623;Note=May be associated with increased risk of ischemic heart disease. K->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11238261,ECO:0000269|PubMed:15520867,ECO:0000269|PubMed:16226177;Dbxref=dbSNP:rs138880920,PMID:11238261,PMID:15520867,PMID:16226177 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 815_815 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062490;Note=Associated with reduced plasma HDL cholesterol. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs145582736,PMID:15297675 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 825_825 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012624;Note=Associated with higher plasma cholesterol. V->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10938021,ECO:0000269|PubMed:11238261,ECO:0000269|PubMed:12709788,ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs2066715,PMID:10938021,PMID:11238261,PMID:12709788,PMID:12966036,PMID:15520867 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 840_840 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062491;Note=In TGD. W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15262183;Dbxref=dbSNP:rs1322998567,PMID:15262183 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 883_883 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012625;Note=Associated with higher plasma cholesterol. I->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431237,ECO:0000269|PubMed:10938021,ECO:0000269|PubMed:11238261,ECO:0000269|PubMed:11257261,ECO:0000269|PubMed:12709788,ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs2066714,PMID:10431237,PMID:10938021,PMID:11238261,PMID:11257261,PMID:12709788,PMID:12966036,PMID:15520867 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 917_917 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_035725;Note=In a colorectal cancer sample%3B somatic mutation. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 929_929 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012626;Note=In TGD%3B moderately decreased protein abundance%3B highly decreased ATPase activity%3B highly decreased phospholipid translocase activity%3B loss protein subcellular localization to the plasma membrane. T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11086027,ECO:0000269|PubMed:24097981;Dbxref=PMID:11086027,PMID:24097981 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 935_935 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009150;Note=In TGD%3B moderately decreased protein abundance%3B highly decreased ATPase activity%3B highly decreased phospholipid translocase activity. N->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431237,ECO:0000269|PubMed:12111381,ECO:0000269|PubMed:24097981;Dbxref=dbSNP:rs28937313,PMID:10431237,PMID:12111381,PMID:24097981 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 935_935 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009150;Note=In TGD%3B moderately decreased protein abundance%3B highly decreased ATPase activity%3B highly decreased phospholipid translocase activity. N->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431237,ECO:0000269|PubMed:12111381,ECO:0000269|PubMed:24097981;Dbxref=dbSNP:rs28937313,PMID:10431237,PMID:12111381,PMID:24097981 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 937_937 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009151;Note=In TGD. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10431237;Dbxref=dbSNP:rs137854495,PMID:10431237 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1046_1046 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012627;Note=In TGD. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10938021;Dbxref=dbSNP:rs141021096,PMID:10938021 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1054_1054 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_037969;Note=V->I;Dbxref=dbSNP:rs13306072 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1065_1065 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062492;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15520867;Dbxref=PMID:15520867 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1068_1068 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062493;Note=In TGD. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15262183;Dbxref=dbSNP:rs745593394,PMID:15262183 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1091_1091 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012628;Note=In FHA1%3B loss of localization to plasma membrane%3B decreased cholesterol efflux%3B decreased phospholipid efflux. M->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10533863,ECO:0000269|PubMed:11086027,ECO:0000269|PubMed:19556522;Dbxref=PMID:10533863,PMID:11086027,PMID:19556522 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1099_1099 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_017530;Note=In FHA1. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12009425;Dbxref=dbSNP:rs28933692,PMID:12009425 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1172_1172 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012629;Note=Associated with premature coronary heart disease. E->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11238261,ECO:0000269|PubMed:11257261,ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs33918808,PMID:11238261,PMID:11257261,PMID:12966036,PMID:15520867 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1181_1181 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_017016;Note=Associated with reduced plasma HDL cholesterol. S->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs76881554,PMID:12966036,PMID:15297675 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1216_1216 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062494;Note=G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs562403512,PMID:15520867 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1289_1289 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009152;Note=In TGD. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10706591,ECO:0000269|PubMed:11476965;Dbxref=dbSNP:rs137854500,PMID:10706591,PMID:11476965 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1341_1341 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062495;Note=Associated with reduced plasma HDL cholesterol. R->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs147743782,PMID:15297675 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1376_1376 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062496;Note=S->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs145689805,PMID:15297675 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1379_1379 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062497;Note=In TGD%3B the mutant protein is retained in the endoplasmic reticulum while the wild-type protein is located at the plasma membrane. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15158913;Dbxref=PMID:15158913 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1407_1407 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_035726;Note=In a colorectal cancer sample%3B somatic mutation. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs189206655,PMID:16959974 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1477_1477 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009153;Note=In TGD%3B loss of interaction with APOE%3B unable to generate APOE-containing high density lipoproteins%3B moderately decreased protein abundance%3B moderately decreased ATPase activity%3B moderately decreased phospholipid translocase activity. C->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431236,ECO:0000269|PubMed:11086027,ECO:0000269|PubMed:14754908,ECO:0000269|PubMed:24097981;Dbxref=dbSNP:rs137854494,PMID:10431236,PMID:11086027,PMID:14754908,PMID:24097981 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1506_1506 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012630;Note=In TGD. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11476961;Dbxref=dbSNP:rs137854497,PMID:11476961 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1517_1517 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009154;Note=In TGD. I->R Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1555_1555 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012638;Note=I->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092505,ECO:0000269|PubMed:10431238;Dbxref=dbSNP:rs1997618,PMID:10092505,PMID:10431238 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1587_1587 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012631;Note=Associated with HDL cholesterol. K->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092505,ECO:0000269|PubMed:10431238,ECO:0000269|PubMed:10884428,ECO:0000269|PubMed:10938021,ECO:0000269|PubMed:11238261,ECO:0000269|PubMed:11352567,ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:15520867,ECO:0000269|Ref.2;Dbxref=dbSNP:rs2230808,PMID:10092505,PMID:10431238,PMID:10884428,PMID:10938021,PMID:11238261,PMID:11352567,PMID:12966036,PMID:15520867 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1611_1611 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012632;Note=Probable disease-associated variant%3B associated with atherosclerosis%3B deficient cellular cholesterol efflux. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11785958;Dbxref=PMID:11785958 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1615_1615 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062498;Note=Associated with reduced plasma HDL cholesterol. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs1251839800,PMID:15297675 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1648_1648 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012639;Note=L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092505,ECO:0000269|PubMed:10431238;Dbxref=dbSNP:rs1883024,PMID:10092505,PMID:10431238 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1670_1670 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062499;Note=Associated with reduced plasma HDL cholesterol. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs1203589782,PMID:15297675 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1680_1680 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_037970;Note=In TGD. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12111371;Dbxref=dbSNP:rs137854498,PMID:12111371 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1680_1680 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_037970;Note=In TGD. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12111371;Dbxref=dbSNP:rs137854498,PMID:12111371 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1704_1704 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062501;Note=In TGD%3B the mutant protein is retained in the endoplasmic reticulum while the wild-type protein is located at the plasma membrane. V->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15158913;Dbxref=PMID:15158913 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1731_1731 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012633;Note=S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11238261;Dbxref=dbSNP:rs760507032,PMID:11238261 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1800_1800 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_009155;Note=In TGD. N->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10706591,ECO:0000269|PubMed:15019541,ECO:0000269|PubMed:15297675,ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs146292819,PMID:10706591,PMID:15019541,PMID:15297675,PMID:15520867 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1851_1851 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062502;Note=In TGD. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14576201;Dbxref=dbSNP:rs1055285452,PMID:14576201 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1893_1894 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012634;Note=In FHA1. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10533863,ECO:0000269|PubMed:11086027;Dbxref=PMID:10533863,PMID:11086027 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1897_1897 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062503;Note=In FHA1%3B uncertain pathological significance. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15722566;Dbxref=dbSNP:rs760768125,PMID:15722566 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1901_1901 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062504;Note=In TGD. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15019541;Dbxref=PMID:15019541 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1925_1925 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062505;Note=In Scott syndrome%3B shows impaired trafficking of the mutant protein to the plasma membrane. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15790791;Dbxref=dbSNP:rs142688906,PMID:15790791 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 2009_2009 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_037971;Note=In FHA1. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12009425;Dbxref=dbSNP:rs137854499,PMID:12009425 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 2081_2081 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012635;Note=In TGD%3B highly decreased protein abundance%3B highly decreased ATPase activity%3B highly decreased phospholipid translocase activity%3B loss protein subcellular localization to the plasma membrane. R->W;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11476965,ECO:0000269|PubMed:24097981;Dbxref=dbSNP:rs137854501,PMID:11476965,PMID:24097981 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 2109_2109 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_035727;Note=In a colorectal cancer sample%3B somatic mutation. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 2150_2150 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012636;Note=In FHA1%3B moderately decreased protein abundance%3B does not affect ATPase activity%3B moderately decreased phospholipid translocase activity. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11086027,ECO:0000269|PubMed:24097981;Dbxref=dbSNP:rs369098049,PMID:11086027,PMID:24097981 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 2163_2163 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062506;Note=Could be associated with reduced plasma HDL cholesterol. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15262183;Dbxref=PMID:15262183 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 2168_2168 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_012637;Note=L->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092505,ECO:0000269|PubMed:10431238,ECO:0000269|PubMed:11257260;Dbxref=dbSNP:rs2853577,PMID:10092505,PMID:10431238,PMID:11257260 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 2196_2196 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062507;Note=In TGD. Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15019541;Dbxref=dbSNP:rs564764153,PMID:15019541 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 2243_2243 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062508;Note=D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs34879708,PMID:15297675 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 2244_2244 140.33333333333334 2262.0 not_retained Natural variant ID=VAR_062509;Note=Could be associated with reduced plasma HDL cholesterol. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15262183;Dbxref=dbSNP:rs144588452,PMID:15262183 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 3_3 140.33333333333334 2262.0 retained Mutagenesis Note=Mild decrease of palmitoylation. Loss of localization to plasma membrane. Decreased cholesterol efflux. Decreased phospholipid efflux. Decreased palmitoylation%3B when associated with S-23%2C S-1110 and S-1111. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 23_23 140.33333333333334 2262.0 retained Mutagenesis Note=Mild decrease of palmitoylation. Loss of localization to plasma membrane. Decreased palmitoylation%3B when associated with S-3%2C S-1110 and S-1111. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 100_100 140.33333333333334 2262.0 retained Mutagenesis Note=Highly decreased protein abundance. Highly decreased ATPase activity. Highly decreased phospholipid translocase activity. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24097981;Dbxref=PMID:24097981 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 593_593 140.33333333333334 2262.0 not_retained Mutagenesis Note=Moderately decreased protein abundance. Highly decreased ATPase activity. Highly decreased phospholipid translocase activity. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24097981;Dbxref=PMID:24097981 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 939_939 140.33333333333334 2262.0 not_retained Mutagenesis Note=Inhibits ATPase activity%3B when associated with M-1952. Decreases translocase activity%3B when associated with M-1952. Does not affect protein subcellular localization in plasma membrane and endosome%3B when associated with M-1952. K->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24097981;Dbxref=PMID:24097981 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1110_1110 140.33333333333334 2262.0 not_retained Mutagenesis Note=Decreased palmitoylation%3B when associated with S-3%2C S-23 and S-1111. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1111_1111 140.33333333333334 2262.0 not_retained Mutagenesis Note=Decreased palmitoylation%3B when associated with S-3%2C S-23 and S-1110. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1512_1512 140.33333333333334 2262.0 not_retained Mutagenesis Note=Moderately decreased protein abundance. Does not affect ATPase activity. Moderately decreased phospholipid translocase activity. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24097981;Dbxref=PMID:24097981 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1952_1952 140.33333333333334 2262.0 not_retained Mutagenesis Note=Inhibits ATPase activity%3B when associated with M-939. Decreases translocase activity%3B when associated with M-939. Does not affect protein subcellular localization in plasma membrane and endosome%3B when associated with M-939. K->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24097981;Dbxref=PMID:24097981 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 793_793 140.33333333333334 2262.0 not_retained Sequence conflict Note=Y->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 831_831 140.33333333333334 2262.0 not_retained Sequence conflict Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1005_1005 140.33333333333334 2262.0 not_retained Sequence conflict Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene ABCA1 chr9:107645320 - ZNF483 chr9:114338645 ENST00000374736 O95477 5 50 1745_1746 140.33333333333334 2262.0 not_retained Sequence conflict Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1_2261 22.0 2262.0 not_retained Chain ID=PRO_0000093288;Note=Phospholipid-transporting ATPase ABCA1 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 22_42 22.0 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 43_639 22.0 2262.0 not_retained Topological domain Note=Extracellular Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 640_660 22.0 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 683_703 22.0 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 716_736 22.0 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 745_765 22.0 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 777_797 22.0 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 827_847 22.0 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1041_1057 22.0 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1351_1371 22.0 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1372_1656 22.0 2262.0 not_retained Topological domain Note=Extracellular Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1657_1677 22.0 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1703_1723 22.0 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1735_1755 22.0 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1768_1788 22.0 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1802_1822 22.0 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1852_1872 22.0 2262.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 899_1131 22.0 2262.0 not_retained Domain Note=ABC transporter 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1912_2144 22.0 2262.0 not_retained Domain Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 933_940 22.0 2262.0 not_retained Nucleotide binding Note=ATP 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1946_1953 22.0 2262.0 not_retained Nucleotide binding Note=ATP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1042_1042 22.0 2262.0 not_retained Modified residue Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12196520;Dbxref=PMID:12196520 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1296_1296 22.0 2262.0 not_retained Modified residue Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41233 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 2054_2054 22.0 2262.0 not_retained Modified residue Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12196520;Dbxref=PMID:12196520 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 3_3 22.0 2262.0 retained Mutagenesis Note=Mild decrease of palmitoylation. Loss of localization to plasma membrane. Decreased cholesterol efflux. Decreased phospholipid efflux. Decreased palmitoylation%3B when associated with S-23%2C S-1110 and S-1111. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 23_23 22.0 2262.0 retained Mutagenesis Note=Mild decrease of palmitoylation. Loss of localization to plasma membrane. Decreased palmitoylation%3B when associated with S-3%2C S-1110 and S-1111. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1110_1110 22.0 2262.0 not_retained Mutagenesis Note=Decreased palmitoylation%3B when associated with S-3%2C S-23 and S-1111. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1111_1111 22.0 2262.0 not_retained Mutagenesis Note=Decreased palmitoylation%3B when associated with S-3%2C S-23 and S-1110. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 14_14 22.0 2262.0 retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 98_98 22.0 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 151_151 22.0 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 161_161 22.0 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 196_196 22.0 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 244_244 22.0 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 292_292 22.0 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 337_337 22.0 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 349_349 22.0 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 400_400 22.0 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 478_478 22.0 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 489_489 22.0 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 521_521 22.0 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 820_820 22.0 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1144_1144 22.0 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1294_1294 22.0 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1453_1453 22.0 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1504_1504 22.0 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1637_1637 22.0 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 2044_2044 22.0 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 2238_2238 22.0 2262.0 not_retained Glycosylation Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 75_309 22.0 2262.0 not_retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19258317;Dbxref=PMID:19258317 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1463_1477 22.0 2262.0 not_retained Disulfide bond Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19258317;Dbxref=PMID:19258317 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 85_85 22.0 2262.0 not_retained Natural variant ID=VAR_017529;Note=In FHA1%3B Alabama. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12204794;Dbxref=dbSNP:rs145183203,PMID:12204794 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 210_210 22.0 2262.0 not_retained Natural variant ID=VAR_035724;Note=In a colorectal cancer sample%3B somatic mutation. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 219_219 22.0 2262.0 not_retained Natural variant ID=VAR_012618;Note=Associated with a decreased severity of CAD. R->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10938021,ECO:0000269|PubMed:11238261,ECO:0000269|PubMed:11257261,ECO:0000269|PubMed:11476965,ECO:0000269|PubMed:12624133,ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs2230806,PMID:10938021,PMID:11238261,PMID:11257261,PMID:11476965,PMID:12624133,PMID:12966036,PMID:15520867 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 230_230 22.0 2262.0 not_retained Natural variant ID=VAR_012619;Note=R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10938021,ECO:0000269|PubMed:27535533;Dbxref=dbSNP:rs9282541,PMID:10938021,PMID:27535533 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 248_248 22.0 2262.0 not_retained Natural variant ID=VAR_062481;Note=P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs142625938,PMID:15297675 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 255_255 22.0 2262.0 not_retained Natural variant ID=VAR_012620;Note=In TGD%3B deficient cellular cholesterol efflux. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11785958;Dbxref=dbSNP:rs758100110,PMID:11785958 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 284_284 22.0 2262.0 not_retained Natural variant ID=VAR_062482;Note=In TGD. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15019541;Dbxref=PMID:15019541 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 364_364 22.0 2262.0 not_retained Natural variant ID=VAR_062483;Note=S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs775035559,PMID:15520867 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 399_399 22.0 2262.0 not_retained Natural variant ID=VAR_009145;Note=V->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431237,ECO:0000269|PubMed:11238261;Dbxref=dbSNP:rs9282543,PMID:10431237,PMID:11238261 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 401_401 22.0 2262.0 not_retained Natural variant ID=VAR_062484;Note=K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs138487227,PMID:15297675 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 482_482 22.0 2262.0 not_retained Natural variant ID=VAR_062485;Note=In TGD. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15019541;Dbxref=PMID:15019541 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 496_496 22.0 2262.0 not_retained Natural variant ID=VAR_062486;Note=Associated with increased plasma HDL cholesterol. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs147675550,PMID:15297675 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 587_587 22.0 2262.0 not_retained Natural variant ID=VAR_009146;Note=In TGD. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11257260;Dbxref=dbSNP:rs2853574,PMID:11257260 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 590_590 22.0 2262.0 not_retained Natural variant ID=VAR_009147;Note=In TGD%3B moderately decreased protein abundance%3B highly decreased ATPase activity%3B highly decreased phospholipid translocase activity. W->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431237,ECO:0000269|PubMed:15297675,ECO:0000269|PubMed:24097981;Dbxref=dbSNP:rs137854496,PMID:10431237,PMID:15297675,PMID:24097981 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 590_590 22.0 2262.0 not_retained Natural variant ID=VAR_009147;Note=In TGD%3B moderately decreased protein abundance%3B highly decreased ATPase activity%3B highly decreased phospholipid translocase activity. W->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431237,ECO:0000269|PubMed:15297675,ECO:0000269|PubMed:24097981;Dbxref=dbSNP:rs137854496,PMID:10431237,PMID:15297675,PMID:24097981 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 597_597 22.0 2262.0 not_retained Natural variant ID=VAR_009148;Note=In TGD. Q->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431236,ECO:0000269|PubMed:11086027;Dbxref=dbSNP:rs2853578,PMID:10431236,PMID:11086027 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 638_638 22.0 2262.0 not_retained Natural variant ID=VAR_062488;Note=Associated with reduced plasma HDL cholesterol. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs374190304,PMID:15297675 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 693_693 22.0 2262.0 not_retained Natural variant ID=VAR_009149;Note=In FHA1. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431236,ECO:0000269|PubMed:11086027;Dbxref=PMID:10431236,PMID:11086027 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 771_771 22.0 2262.0 not_retained Natural variant ID=VAR_012621;Note=Associated with HDL cholesterol. V->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11238261,ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:15262183,ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs2066718,PMID:11238261,PMID:12966036,PMID:15262183,PMID:15520867 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 774_774 22.0 2262.0 not_retained Natural variant ID=VAR_062489;Note=T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=PMID:15297675 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 774_774 22.0 2262.0 not_retained Natural variant ID=VAR_062489;Note=T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=PMID:15297675 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 776_776 22.0 2262.0 not_retained Natural variant ID=VAR_012623;Note=May be associated with increased risk of ischemic heart disease. K->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11238261,ECO:0000269|PubMed:15520867,ECO:0000269|PubMed:16226177;Dbxref=dbSNP:rs138880920,PMID:11238261,PMID:15520867,PMID:16226177 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 815_815 22.0 2262.0 not_retained Natural variant ID=VAR_062490;Note=Associated with reduced plasma HDL cholesterol. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs145582736,PMID:15297675 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 825_825 22.0 2262.0 not_retained Natural variant ID=VAR_012624;Note=Associated with higher plasma cholesterol. V->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10938021,ECO:0000269|PubMed:11238261,ECO:0000269|PubMed:12709788,ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs2066715,PMID:10938021,PMID:11238261,PMID:12709788,PMID:12966036,PMID:15520867 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 840_840 22.0 2262.0 not_retained Natural variant ID=VAR_062491;Note=In TGD. W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15262183;Dbxref=dbSNP:rs1322998567,PMID:15262183 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 883_883 22.0 2262.0 not_retained Natural variant ID=VAR_012625;Note=Associated with higher plasma cholesterol. I->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431237,ECO:0000269|PubMed:10938021,ECO:0000269|PubMed:11238261,ECO:0000269|PubMed:11257261,ECO:0000269|PubMed:12709788,ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs2066714,PMID:10431237,PMID:10938021,PMID:11238261,PMID:11257261,PMID:12709788,PMID:12966036,PMID:15520867 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 917_917 22.0 2262.0 not_retained Natural variant ID=VAR_035725;Note=In a colorectal cancer sample%3B somatic mutation. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 929_929 22.0 2262.0 not_retained Natural variant ID=VAR_012626;Note=In TGD%3B moderately decreased protein abundance%3B highly decreased ATPase activity%3B highly decreased phospholipid translocase activity%3B loss protein subcellular localization to the plasma membrane. T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11086027,ECO:0000269|PubMed:24097981;Dbxref=PMID:11086027,PMID:24097981 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 935_935 22.0 2262.0 not_retained Natural variant ID=VAR_009150;Note=In TGD%3B moderately decreased protein abundance%3B highly decreased ATPase activity%3B highly decreased phospholipid translocase activity. N->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431237,ECO:0000269|PubMed:12111381,ECO:0000269|PubMed:24097981;Dbxref=dbSNP:rs28937313,PMID:10431237,PMID:12111381,PMID:24097981 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 935_935 22.0 2262.0 not_retained Natural variant ID=VAR_009150;Note=In TGD%3B moderately decreased protein abundance%3B highly decreased ATPase activity%3B highly decreased phospholipid translocase activity. N->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431237,ECO:0000269|PubMed:12111381,ECO:0000269|PubMed:24097981;Dbxref=dbSNP:rs28937313,PMID:10431237,PMID:12111381,PMID:24097981 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 937_937 22.0 2262.0 not_retained Natural variant ID=VAR_009151;Note=In TGD. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10431237;Dbxref=dbSNP:rs137854495,PMID:10431237 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1046_1046 22.0 2262.0 not_retained Natural variant ID=VAR_012627;Note=In TGD. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10938021;Dbxref=dbSNP:rs141021096,PMID:10938021 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1054_1054 22.0 2262.0 not_retained Natural variant ID=VAR_037969;Note=V->I;Dbxref=dbSNP:rs13306072 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1065_1065 22.0 2262.0 not_retained Natural variant ID=VAR_062492;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15520867;Dbxref=PMID:15520867 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1068_1068 22.0 2262.0 not_retained Natural variant ID=VAR_062493;Note=In TGD. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15262183;Dbxref=dbSNP:rs745593394,PMID:15262183 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1091_1091 22.0 2262.0 not_retained Natural variant ID=VAR_012628;Note=In FHA1%3B loss of localization to plasma membrane%3B decreased cholesterol efflux%3B decreased phospholipid efflux. M->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10533863,ECO:0000269|PubMed:11086027,ECO:0000269|PubMed:19556522;Dbxref=PMID:10533863,PMID:11086027,PMID:19556522 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1099_1099 22.0 2262.0 not_retained Natural variant ID=VAR_017530;Note=In FHA1. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12009425;Dbxref=dbSNP:rs28933692,PMID:12009425 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1172_1172 22.0 2262.0 not_retained Natural variant ID=VAR_012629;Note=Associated with premature coronary heart disease. E->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11238261,ECO:0000269|PubMed:11257261,ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs33918808,PMID:11238261,PMID:11257261,PMID:12966036,PMID:15520867 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1181_1181 22.0 2262.0 not_retained Natural variant ID=VAR_017016;Note=Associated with reduced plasma HDL cholesterol. S->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs76881554,PMID:12966036,PMID:15297675 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1216_1216 22.0 2262.0 not_retained Natural variant ID=VAR_062494;Note=G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs562403512,PMID:15520867 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1289_1289 22.0 2262.0 not_retained Natural variant ID=VAR_009152;Note=In TGD. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10706591,ECO:0000269|PubMed:11476965;Dbxref=dbSNP:rs137854500,PMID:10706591,PMID:11476965 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1341_1341 22.0 2262.0 not_retained Natural variant ID=VAR_062495;Note=Associated with reduced plasma HDL cholesterol. R->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs147743782,PMID:15297675 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1376_1376 22.0 2262.0 not_retained Natural variant ID=VAR_062496;Note=S->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs145689805,PMID:15297675 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1379_1379 22.0 2262.0 not_retained Natural variant ID=VAR_062497;Note=In TGD%3B the mutant protein is retained in the endoplasmic reticulum while the wild-type protein is located at the plasma membrane. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15158913;Dbxref=PMID:15158913 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1407_1407 22.0 2262.0 not_retained Natural variant ID=VAR_035726;Note=In a colorectal cancer sample%3B somatic mutation. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs189206655,PMID:16959974 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1477_1477 22.0 2262.0 not_retained Natural variant ID=VAR_009153;Note=In TGD%3B loss of interaction with APOE%3B unable to generate APOE-containing high density lipoproteins%3B moderately decreased protein abundance%3B moderately decreased ATPase activity%3B moderately decreased phospholipid translocase activity. C->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10431236,ECO:0000269|PubMed:11086027,ECO:0000269|PubMed:14754908,ECO:0000269|PubMed:24097981;Dbxref=dbSNP:rs137854494,PMID:10431236,PMID:11086027,PMID:14754908,PMID:24097981 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1506_1506 22.0 2262.0 not_retained Natural variant ID=VAR_012630;Note=In TGD. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11476961;Dbxref=dbSNP:rs137854497,PMID:11476961 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1517_1517 22.0 2262.0 not_retained Natural variant ID=VAR_009154;Note=In TGD. I->R Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1555_1555 22.0 2262.0 not_retained Natural variant ID=VAR_012638;Note=I->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092505,ECO:0000269|PubMed:10431238;Dbxref=dbSNP:rs1997618,PMID:10092505,PMID:10431238 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1587_1587 22.0 2262.0 not_retained Natural variant ID=VAR_012631;Note=Associated with HDL cholesterol. K->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092505,ECO:0000269|PubMed:10431238,ECO:0000269|PubMed:10884428,ECO:0000269|PubMed:10938021,ECO:0000269|PubMed:11238261,ECO:0000269|PubMed:11352567,ECO:0000269|PubMed:12966036,ECO:0000269|PubMed:15520867,ECO:0000269|Ref.2;Dbxref=dbSNP:rs2230808,PMID:10092505,PMID:10431238,PMID:10884428,PMID:10938021,PMID:11238261,PMID:11352567,PMID:12966036,PMID:15520867 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1611_1611 22.0 2262.0 not_retained Natural variant ID=VAR_012632;Note=Probable disease-associated variant%3B associated with atherosclerosis%3B deficient cellular cholesterol efflux. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11785958;Dbxref=PMID:11785958 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1615_1615 22.0 2262.0 not_retained Natural variant ID=VAR_062498;Note=Associated with reduced plasma HDL cholesterol. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs1251839800,PMID:15297675 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1648_1648 22.0 2262.0 not_retained Natural variant ID=VAR_012639;Note=L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092505,ECO:0000269|PubMed:10431238;Dbxref=dbSNP:rs1883024,PMID:10092505,PMID:10431238 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1670_1670 22.0 2262.0 not_retained Natural variant ID=VAR_062499;Note=Associated with reduced plasma HDL cholesterol. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs1203589782,PMID:15297675 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1680_1680 22.0 2262.0 not_retained Natural variant ID=VAR_037970;Note=In TGD. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12111371;Dbxref=dbSNP:rs137854498,PMID:12111371 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1680_1680 22.0 2262.0 not_retained Natural variant ID=VAR_037970;Note=In TGD. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12111371;Dbxref=dbSNP:rs137854498,PMID:12111371 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1704_1704 22.0 2262.0 not_retained Natural variant ID=VAR_062501;Note=In TGD%3B the mutant protein is retained in the endoplasmic reticulum while the wild-type protein is located at the plasma membrane. V->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15158913;Dbxref=PMID:15158913 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1731_1731 22.0 2262.0 not_retained Natural variant ID=VAR_012633;Note=S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11238261;Dbxref=dbSNP:rs760507032,PMID:11238261 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1800_1800 22.0 2262.0 not_retained Natural variant ID=VAR_009155;Note=In TGD. N->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10706591,ECO:0000269|PubMed:15019541,ECO:0000269|PubMed:15297675,ECO:0000269|PubMed:15520867;Dbxref=dbSNP:rs146292819,PMID:10706591,PMID:15019541,PMID:15297675,PMID:15520867 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1851_1851 22.0 2262.0 not_retained Natural variant ID=VAR_062502;Note=In TGD. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14576201;Dbxref=dbSNP:rs1055285452,PMID:14576201 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1893_1894 22.0 2262.0 not_retained Natural variant ID=VAR_012634;Note=In FHA1. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10533863,ECO:0000269|PubMed:11086027;Dbxref=PMID:10533863,PMID:11086027 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1897_1897 22.0 2262.0 not_retained Natural variant ID=VAR_062503;Note=In FHA1%3B uncertain pathological significance. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15722566;Dbxref=dbSNP:rs760768125,PMID:15722566 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1901_1901 22.0 2262.0 not_retained Natural variant ID=VAR_062504;Note=In TGD. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15019541;Dbxref=PMID:15019541 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1925_1925 22.0 2262.0 not_retained Natural variant ID=VAR_062505;Note=In Scott syndrome%3B shows impaired trafficking of the mutant protein to the plasma membrane. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15790791;Dbxref=dbSNP:rs142688906,PMID:15790791 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 2009_2009 22.0 2262.0 not_retained Natural variant ID=VAR_037971;Note=In FHA1. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12009425;Dbxref=dbSNP:rs137854499,PMID:12009425 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 2081_2081 22.0 2262.0 not_retained Natural variant ID=VAR_012635;Note=In TGD%3B highly decreased protein abundance%3B highly decreased ATPase activity%3B highly decreased phospholipid translocase activity%3B loss protein subcellular localization to the plasma membrane. R->W;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11476965,ECO:0000269|PubMed:24097981;Dbxref=dbSNP:rs137854501,PMID:11476965,PMID:24097981 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 2109_2109 22.0 2262.0 not_retained Natural variant ID=VAR_035727;Note=In a colorectal cancer sample%3B somatic mutation. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 2150_2150 22.0 2262.0 not_retained Natural variant ID=VAR_012636;Note=In FHA1%3B moderately decreased protein abundance%3B does not affect ATPase activity%3B moderately decreased phospholipid translocase activity. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11086027,ECO:0000269|PubMed:24097981;Dbxref=dbSNP:rs369098049,PMID:11086027,PMID:24097981 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 2163_2163 22.0 2262.0 not_retained Natural variant ID=VAR_062506;Note=Could be associated with reduced plasma HDL cholesterol. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15262183;Dbxref=PMID:15262183 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 2168_2168 22.0 2262.0 not_retained Natural variant ID=VAR_012637;Note=L->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092505,ECO:0000269|PubMed:10431238,ECO:0000269|PubMed:11257260;Dbxref=dbSNP:rs2853577,PMID:10092505,PMID:10431238,PMID:11257260 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 2196_2196 22.0 2262.0 not_retained Natural variant ID=VAR_062507;Note=In TGD. Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15019541;Dbxref=dbSNP:rs564764153,PMID:15019541 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 2243_2243 22.0 2262.0 not_retained Natural variant ID=VAR_062508;Note=D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15297675;Dbxref=dbSNP:rs34879708,PMID:15297675 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 2244_2244 22.0 2262.0 not_retained Natural variant ID=VAR_062509;Note=Could be associated with reduced plasma HDL cholesterol. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15262183;Dbxref=dbSNP:rs144588452,PMID:15262183 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 3_3 22.0 2262.0 retained Mutagenesis Note=Mild decrease of palmitoylation. Loss of localization to plasma membrane. Decreased cholesterol efflux. Decreased phospholipid efflux. Decreased palmitoylation%3B when associated with S-23%2C S-1110 and S-1111. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 23_23 22.0 2262.0 retained Mutagenesis Note=Mild decrease of palmitoylation. Loss of localization to plasma membrane. Decreased palmitoylation%3B when associated with S-3%2C S-1110 and S-1111. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 100_100 22.0 2262.0 not_retained Mutagenesis Note=Highly decreased protein abundance. Highly decreased ATPase activity. Highly decreased phospholipid translocase activity. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24097981;Dbxref=PMID:24097981 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 593_593 22.0 2262.0 not_retained Mutagenesis Note=Moderately decreased protein abundance. Highly decreased ATPase activity. Highly decreased phospholipid translocase activity. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24097981;Dbxref=PMID:24097981 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 939_939 22.0 2262.0 not_retained Mutagenesis Note=Inhibits ATPase activity%3B when associated with M-1952. Decreases translocase activity%3B when associated with M-1952. Does not affect protein subcellular localization in plasma membrane and endosome%3B when associated with M-1952. K->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24097981;Dbxref=PMID:24097981 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1110_1110 22.0 2262.0 not_retained Mutagenesis Note=Decreased palmitoylation%3B when associated with S-3%2C S-23 and S-1111. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1111_1111 22.0 2262.0 not_retained Mutagenesis Note=Decreased palmitoylation%3B when associated with S-3%2C S-23 and S-1110. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19556522;Dbxref=PMID:19556522 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1512_1512 22.0 2262.0 not_retained Mutagenesis Note=Moderately decreased protein abundance. Does not affect ATPase activity. Moderately decreased phospholipid translocase activity. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24097981;Dbxref=PMID:24097981 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1952_1952 22.0 2262.0 not_retained Mutagenesis Note=Inhibits ATPase activity%3B when associated with M-939. Decreases translocase activity%3B when associated with M-939. Does not affect protein subcellular localization in plasma membrane and endosome%3B when associated with M-939. K->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24097981;Dbxref=PMID:24097981 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 793_793 22.0 2262.0 not_retained Sequence conflict Note=Y->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 831_831 22.0 2262.0 not_retained Sequence conflict Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1005_1005 22.0 2262.0 not_retained Sequence conflict Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene ABCA1 chr9:107665894 - KCNMA1 chr10:78850268 ENST00000374736 O95477 2 50 1745_1746 22.0 2262.0 not_retained Sequence conflict Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Hgene ABCA2 chr9:139922526 - TRIM14 chr9:100862446 ENST00000341511 Q9BZC7 1 49 1_2435 22.0 2437.0 not_retained Chain ID=PRO_0000093290;Note=ATP-binding cassette sub-family A member 2 Hgene ABCA2 chr9:139922526 - TRIM14 chr9:100862446 ENST00000341511 Q9BZC7 1 49 22_42 22.0 2437.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA2 chr9:139922526 - TRIM14 chr9:100862446 ENST00000341511 Q9BZC7 1 49 54_74 22.0 2437.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA2 chr9:139922526 - TRIM14 chr9:100862446 ENST00000341511 Q9BZC7 1 49 699_719 22.0 2437.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA2 chr9:139922526 - TRIM14 chr9:100862446 ENST00000341511 Q9BZC7 1 49 750_770 22.0 2437.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA2 chr9:139922526 - TRIM14 chr9:100862446 ENST00000341511 Q9BZC7 1 49 782_802 22.0 2437.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA2 chr9:139922526 - TRIM14 chr9:100862446 ENST00000341511 Q9BZC7 1 49 813_833 22.0 2437.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA2 chr9:139922526 - TRIM14 chr9:100862446 ENST00000341511 Q9BZC7 1 49 857_877 22.0 2437.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA2 chr9:139922526 - TRIM14 chr9:100862446 ENST00000341511 Q9BZC7 1 49 893_913 22.0 2437.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA2 chr9:139922526 - TRIM14 chr9:100862446 ENST00000341511 Q9BZC7 1 49 1456_1476 22.0 2437.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA2 chr9:139922526 - TRIM14 chr9:100862446 ENST00000341511 Q9BZC7 1 49 1792_1812 22.0 2437.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA2 chr9:139922526 - TRIM14 chr9:100862446 ENST00000341511 Q9BZC7 1 49 1841_1861 22.0 2437.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA2 chr9:139922526 - TRIM14 chr9:100862446 ENST00000341511 Q9BZC7 1 49 1872_1892 22.0 2437.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA2 chr9:139922526 - TRIM14 chr9:100862446 ENST00000341511 Q9BZC7 1 49 1905_1925 22.0 2437.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA2 chr9:139922526 - TRIM14 chr9:100862446 ENST00000341511 Q9BZC7 1 49 1991_2011 22.0 2437.0 not_retained Transmembrane Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Hgene ABCA2 chr9:139922526 - TRIM14 chr9:10086244