Home

Download

Statistics

Examples

Help

Contact

Fusion Protein:ZNF587-BAX

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ZNF587-BAX
	FusionPDB ID: 102466
	FusionGDB2.0 ID: 102466
		Hgene	Tgene
	Gene symbol	ZNF587	BAX
	Gene ID	84914	581
	Gene name	zinc finger protein 587	BCL2 associated X, apoptosis regulator
	Synonyms	ZF6	BCL2L4
	Cytomap	19q13.43	19q13.33
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 587zinc finger protein zfp6	apoptosis regulator BAXBCL2 associated X proteinBCL2-associated X protein omegaBaxdelta2G9Baxdelta2G9omegaBaxdelta2omegabcl-2-like protein 4bcl2-L-4
	Modification date	20200313	20200322
	UniProtAcc	.	TMBIM6 Main function of 5'-partner protein: 237
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000339656, ENST00000419854, ENST00000423137, ENST00000596433,	ENST00000293288, ENST00000354470, ENST00000391871, ENST00000415969, ENST00000345358, ENST00000539787,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	11 X 12 X 6=792	4 X 3 X 3=36
	# samples	14	6
	** MAII score	log2(14/792*10)=-2.50007360313464 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Fusion gene context	PubMed: ZNF587 [Title/Abstract] AND BAX [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: ZNF587 [Title/Abstract] AND BAX [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ZNF587(58367601)-BAX(49464066), # samples:1 ZNF587(58367601)-BAX(49464067), # samples:1 ZNF587(58367600)-BAX(49464066), # samples:1
Anticipated loss of major functional domain due to fusion event.	ZNF587-BAX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ZNF587-BAX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ZNF587-BAX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ZNF587-BAX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ZNF587-BAX seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. ZNF587-BAX seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. ZNF587-BAX seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	BAX	GO:0001783	B cell apoptotic process	15214043\|16424160
Tgene	BAX	GO:0001836	release of cytochrome c from mitochondria	9843949\|16199525\|17052454
Tgene	BAX	GO:0006915	apoptotic process	9660918
Tgene	BAX	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	11912183
Tgene	BAX	GO:0008053	mitochondrial fusion	14769861
Tgene	BAX	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	15214043
Tgene	BAX	GO:0008637	apoptotic mitochondrial changes	9843949
Tgene	BAX	GO:0009636	response to toxic substance	16307838
Tgene	BAX	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient	9843949
Tgene	BAX	GO:0010917	negative regulation of mitochondrial membrane potential	16751333
Tgene	BAX	GO:0031334	positive regulation of protein complex assembly	9111042\|19805544
Tgene	BAX	GO:0032091	negative regulation of protein binding	9388232
Tgene	BAX	GO:0032976	release of matrix enzymes from mitochondria	9843949
Tgene	BAX	GO:0043065	positive regulation of apoptotic process	16751333\|17464193
Tgene	BAX	GO:0043525	positive regulation of neuron apoptotic process	15637643
Tgene	BAX	GO:0043653	mitochondrial fragmentation involved in apoptotic process	12499352
Tgene	BAX	GO:0051881	regulation of mitochondrial membrane potential	9843949
Tgene	BAX	GO:0090200	positive regulation of release of cytochrome c from mitochondria	14963330
Tgene	BAX	GO:0097190	apoptotic signaling pathway	16424160
Tgene	BAX	GO:0097191	extrinsic apoptotic signaling pathway	15214043
Tgene	BAX	GO:0097193	intrinsic apoptotic signaling pathway	9219694\|16462759
Tgene	BAX	GO:1990117	B cell receptor apoptotic signaling pathway	15214043

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:58367601/chr19:49464066)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across ZNF587 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BAX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000339656	ZNF587	chr19	58367601	+	ENST00000539787	BAX	chr19	49464066	+	675	345	149	553	134
ENST00000423137	ZNF587	chr19	58367601	+	ENST00000539787	BAX	chr19	49464066	+	669	339	146	547	133
ENST00000419854	ZNF587	chr19	58367601	+	ENST00000539787	BAX	chr19	49464066	+	595	265	216	473	85
ENST00000339656	ZNF587	chr19	58367601	+	ENST00000539787	BAX	chr19	49464067	+	675	345	149	553	134
ENST00000423137	ZNF587	chr19	58367601	+	ENST00000539787	BAX	chr19	49464067	+	669	339	146	547	133
ENST00000419854	ZNF587	chr19	58367601	+	ENST00000539787	BAX	chr19	49464067	+	595	265	216	473	85
ENST00000339656	ZNF587	chr19	58367600	+	ENST00000539787	BAX	chr19	49464066	+	675	345	149	553	134
ENST00000423137	ZNF587	chr19	58367600	+	ENST00000539787	BAX	chr19	49464066	+	669	339	146	547	133
ENST00000419854	ZNF587	chr19	58367600	+	ENST00000539787	BAX	chr19	49464066	+	595	265	216	473	85

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000339656	ENST00000539787	ZNF587	chr19	58367601	+	BAX	chr19	49464066	+	0.6728782	0.32712176
ENST00000423137	ENST00000539787	ZNF587	chr19	58367601	+	BAX	chr19	49464066	+	0.6973448	0.3026552
ENST00000419854	ENST00000539787	ZNF587	chr19	58367601	+	BAX	chr19	49464066	+	0.807064	0.19293596
ENST00000339656	ENST00000539787	ZNF587	chr19	58367601	+	BAX	chr19	49464067	+	0.6728782	0.32712176
ENST00000423137	ENST00000539787	ZNF587	chr19	58367601	+	BAX	chr19	49464067	+	0.6973448	0.3026552
ENST00000419854	ENST00000539787	ZNF587	chr19	58367601	+	BAX	chr19	49464067	+	0.807064	0.19293596
ENST00000339656	ENST00000539787	ZNF587	chr19	58367600	+	BAX	chr19	49464066	+	0.6728782	0.32712176
ENST00000423137	ENST00000539787	ZNF587	chr19	58367600	+	BAX	chr19	49464066	+	0.6973448	0.3026552
ENST00000419854	ENST00000539787	ZNF587	chr19	58367600	+	BAX	chr19	49464066	+	0.807064	0.19293596

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

Top

Fusion Protein Breakpoint Sequences for ZNF587-BAX

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
ZNF587	chr19	58367600	BAX	chr19	49464066	265	16	DVMLENLALISSLGPVHQGAGTDQNH
ZNF587	chr19	58367600	BAX	chr19	49464066	339	24	MAAAVPRRPTQGTVTFEDVAVNFSQE
ZNF587	chr19	58367600	BAX	chr19	49464066	345	25	AAAVPRRPTQQGTVTFEDVAVNFSQE
ZNF587	chr19	58367601	BAX	chr19	49464066	265	16	DVMLENLALISSLGPVHQGAGTDQNH
ZNF587	chr19	58367601	BAX	chr19	49464066	339	24	MAAAVPRRPTQGTVTFEDVAVNFSQE
ZNF587	chr19	58367601	BAX	chr19	49464066	345	25	AAAVPRRPTQQGTVTFEDVAVNFSQE
ZNF587	chr19	58367601	BAX	chr19	49464067	265	16	DVMLENLALISSLGPVHQGAGTDQNH
ZNF587	chr19	58367601	BAX	chr19	49464067	339	24	MAAAVPRRPTQGTVTFEDVAVNFSQE
ZNF587	chr19	58367601	BAX	chr19	49464067	345	25	AAAVPRRPTQQGTVTFEDVAVNFSQE

Top

Potential FusionNeoAntigen Information of ZNF587-BAX in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

ZNF587-BAX_58367600_49464066.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B15:03	TQQGTVTF	0.9552	0.8919	8	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B13:01	TQQGTVTF	0.8225	0.9736	8	16
ZNF587-BAX	chr19	58367600	chr19	49464066	265	HLA-A02:13	ALISSLGPV	0.9966	0.6491	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	265	HLA-A02:27	ALISSLGPV	0.9957	0.5509	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	265	HLA-A02:38	ALISSLGPV	0.9943	0.6442	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:01	RPTQGTVTF	0.9812	0.8788	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:08	RPTQGTVTF	0.9771	0.7198	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	265	HLA-A02:22	SLGPVHQGA	0.9751	0.5528	11	20
ZNF587-BAX	chr19	58367600	chr19	49464066	265	HLA-A02:13	SLGPVHQGA	0.9699	0.7069	11	20
ZNF587-BAX	chr19	58367600	chr19	49464066	265	HLA-A02:27	SLGPVHQGA	0.9671	0.6436	11	20
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B15:02	RPTQGTVTF	0.9532	0.8799	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	265	HLA-A02:38	SLGPVHQGA	0.9524	0.6766	11	20
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:05	RPTQGTVTF	0.9252	0.6978	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:03	RPTQGTVTF	0.9055	0.8505	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	265	HLA-A02:19	SLGPVHQGA	0.8705	0.5867	11	20
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B15:18	RPTQGTVTF	0.8554	0.6366	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:04	RPTQGTVTF	0.5897	0.9465	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:02	RPTQGTVTF	0.5897	0.9465	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B27:04	RRPTQGTVTF	0.9998	0.5168	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B07:05	VPRRPTQGTV	0.9974	0.52	4	14
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B07:02	VPRRPTQGTV	0.9972	0.5841	4	14
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B35:01	RPTQQGTVTF	0.9553	0.8687	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B35:08	RPTQQGTVTF	0.9506	0.7008	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B07:10	RRPTQGTVTF	0.9497	0.5551	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B57:01	RPTQQGTVTF	0.9415	0.8697	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B07:02	RRPTQGTVTF	0.9359	0.5276	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B35:05	RPTQQGTVTF	0.9066	0.6342	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:08	RRPTQGTVTF	0.832	0.7003	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:05	RRPTQGTVTF	0.8287	0.5508	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B58:02	RPTQQGTVTF	0.7956	0.7855	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B57:03	RPTQQGTVTF	0.7818	0.8286	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B15:17	RPTQQGTVTF	0.7327	0.7719	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:01	RRPTQGTVTF	0.7195	0.7715	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B15:16	RPTQQGTVTF	0.6858	0.6452	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B58:01	RPTQQGTVTF	0.5573	0.7624	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-A32:13	RPTQQGTVTF	0.5247	0.725	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B07:02	VPRRPTQQGTV	0.9996	0.5795	3	14
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B07:02	VPRRPTQGTVT	0.9996	0.5582	4	15
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B07:05	VPRRPTQQGTV	0.9996	0.527	3	14
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B57:01	RRPTQQGTVTF	0.9955	0.8112	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B58:02	RRPTQQGTVTF	0.9866	0.7536	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B15:17	RRPTQQGTVTF	0.9821	0.6992	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B57:03	RRPTQQGTVTF	0.9756	0.8125	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B15:16	RRPTQQGTVTF	0.9708	0.517	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-A32:13	RRPTQQGTVTF	0.9486	0.7323	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B58:01	RRPTQQGTVTF	0.9394	0.6714	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B15:05	TQQGTVTF	0.7169	0.9599	8	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B15:31	RPTQGTVTF	0.9808	0.8806	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B15:21	RPTQGTVTF	0.9575	0.8437	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B07:12	RPTQGTVTF	0.9018	0.509	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B14:03	RPTQGTVTF	0.7048	0.5997	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:12	RPTQGTVTF	0.5897	0.9465	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B39:10	RPTQGTVTF	0.512	0.6166	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B39:08	RPTQGTVTF	0.4346	0.6635	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-C04:14	RPTQGTVTF	0.0698	0.7949	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-C04:07	RPTQGTVTF	0.01	0.7636	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-C04:10	RPTQGTVTF	0.0093	0.7424	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-C07:95	RRPTQGTVTF	0.9965	0.5024	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-C07:05	RRPTQGTVTF	0.9961	0.8291	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-C07:27	RRPTQGTVTF	0.9947	0.8925	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B07:12	RPTQQGTVTF	0.9939	0.5011	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-C07:19	RRPTQGTVTF	0.992	0.5312	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-C07:29	RRPTQGTVTF	0.9887	0.8188	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B07:12	VPRRPTQGTV	0.9881	0.605	4	14
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-C07:46	RRPTQGTVTF	0.9877	0.7576	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-C07:13	RRPTQGTVTF	0.9872	0.8266	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-C07:10	RRPTQGTVTF	0.9867	0.9019	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-C07:80	RRPTQGTVTF	0.9853	0.8851	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-C07:67	RRPTQGTVTF	0.9853	0.8851	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-C12:16	RRPTQGTVTF	0.9768	0.9283	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B07:12	RRPTQGTVTF	0.9673	0.5889	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B07:04	VPRRPTQGTV	0.9588	0.5295	4	14
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B39:10	RRPTQGTVTF	0.886	0.6092	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B39:10	RPTQQGTVTF	0.7128	0.7172	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-C07:19	RRPTQQGTVTF	0.9994	0.5908	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-C07:05	RRPTQQGTVTF	0.9991	0.8545	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-C07:95	RRPTQQGTVTF	0.9987	0.5171	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-C07:10	RRPTQQGTVTF	0.9982	0.9098	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-C07:80	RRPTQQGTVTF	0.9981	0.9141	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-C07:67	RRPTQQGTVTF	0.9981	0.9141	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-C07:27	RRPTQQGTVTF	0.9981	0.8974	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-C07:46	RRPTQQGTVTF	0.998	0.8189	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-C07:29	RRPTQQGTVTF	0.9968	0.8411	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B07:12	VPRRPTQQGTV	0.9963	0.5931	3	14
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-C07:13	RRPTQQGTVTF	0.9962	0.8648	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B07:04	VPRRPTQQGTV	0.9928	0.5517	3	14
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B15:50	TQQGTVTF	0.9973	0.8297	8	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B15:53	TQQGTVTF	0.994	0.8651	8	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B15:54	TQQGTVTF	0.9929	0.8377	8	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B15:12	TQQGTVTF	0.9876	0.8732	8	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B15:68	TQQGTVTF	0.9866	0.6539	8	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B48:02	TQQGTVTF	0.7494	0.9716	8	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B15:20	TQQGTVTF	0.7082	0.9744	8	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B35:28	TQQGTVTF	0.6882	0.978	8	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B18:04	TQQGTVTF	0.5537	0.9373	8	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B07:13	RPTQGTVTF	0.9985	0.79	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	265	HLA-A02:03	SLGPVHQGA	0.9861	0.6969	11	20
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:77	RPTQGTVTF	0.9812	0.8788	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:23	RPTQGTVTF	0.9811	0.8652	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:20	RPTQGTVTF	0.9784	0.9154	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:11	RPTQGTVTF	0.9593	0.8201	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:30	RPTQGTVTF	0.9454	0.8148	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:17	RPTQGTVTF	0.9454	0.8148	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:13	RPTQGTVTF	0.8899	0.8564	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:24	RPTQGTVTF	0.8525	0.9006	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-C06:08	RRPTQQGTV	0.8388	0.9841	5	14
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B15:13	RPTQGTVTF	0.7995	0.5771	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:09	RPTQGTVTF	0.5897	0.9465	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B67:01	RPTQGTVTF	0.5233	0.5425	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B15:08	RPTQGTVTF	0.2853	0.769	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:43	RPTQGTVTF	0.2829	0.7786	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B18:04	RPTQGTVTF	0.2819	0.8614	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B15:11	RPTQGTVTF	0.272	0.7663	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B57:02	PTQQGTVTF	0.1963	0.777	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-C04:04	RPTQGTVTF	0.1079	0.8015	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B18:07	RPTQGTVTF	0.1024	0.7972	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-C06:17	RRPTQQGTV	0.0563	0.9887	5	14
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-C06:02	RRPTQQGTV	0.0563	0.9887	5	14
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-C04:01	RPTQGTVTF	0.01	0.7636	7	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B27:10	RRPTQGTVTF	0.9998	0.6229	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B27:06	RRPTQGTVTF	0.9994	0.5121	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B07:22	VPRRPTQGTV	0.9972	0.5841	4	14
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B07:09	VPRRPTQGTV	0.9967	0.563	4	14
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-C07:22	RRPTQGTVTF	0.9963	0.5317	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-C06:08	RRPTQGTVTF	0.996	0.9708	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-C07:17	RRPTQGTVTF	0.9898	0.9291	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-C07:02	RRPTQGTVTF	0.9853	0.8851	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B35:77	RPTQQGTVTF	0.9553	0.8687	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B35:23	RPTQQGTVTF	0.9522	0.8698	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B57:10	RPTQQGTVTF	0.9415	0.8697	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B07:22	RRPTQGTVTF	0.9359	0.5276	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B35:30	RPTQQGTVTF	0.9293	0.7873	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B35:17	RPTQQGTVTF	0.9293	0.7873	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B57:04	RPTQQGTVTF	0.9275	0.6296	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:11	RRPTQGTVTF	0.9214	0.7638	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B15:11	RRPTQGTVTF	0.9199	0.7016	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:43	RRPTQGTVTF	0.9197	0.7094	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B35:11	RPTQQGTVTF	0.918	0.7961	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B57:02	RPTQQGTVTF	0.8927	0.7302	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B67:01	RRPTQGTVTF	0.8668	0.5659	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B15:08	RPTQQGTVTF	0.8643	0.6582	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B35:43	RPTQQGTVTF	0.8609	0.6799	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B15:11	RPTQQGTVTF	0.8593	0.6513	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B58:06	RPTQQGTVTF	0.8493	0.711	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B35:13	RPTQQGTVTF	0.8461	0.8372	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:17	RRPTQGTVTF	0.8292	0.6947	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:30	RRPTQGTVTF	0.8292	0.6947	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:77	RRPTQGTVTF	0.7195	0.7715	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B35:23	RRPTQGTVTF	0.7011	0.7875	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B67:01	RPTQQGTVTF	0.6913	0.6427	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-A32:01	RPTQQGTVTF	0.6028	0.7506	6	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B27:10	RRPTQQGTVTF	0.9999	0.5648	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B27:06	RRPTQQGTVTF	0.9999	0.5019	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B07:22	VPRRPTQQGTV	0.9996	0.5795	3	14
ZNF587-BAX	chr19	58367600	chr19	49464066	339	HLA-B07:22	VPRRPTQGTVT	0.9996	0.5582	4	15
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B07:09	VPRRPTQQGTV	0.9995	0.5633	3	14
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-C07:22	RRPTQQGTVTF	0.9988	0.5865	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-C07:02	RRPTQQGTVTF	0.9981	0.9141	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B57:10	RRPTQQGTVTF	0.9955	0.8112	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B57:04	RRPTQQGTVTF	0.9947	0.6433	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B58:06	RRPTQQGTVTF	0.9916	0.7	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-B57:02	RRPTQQGTVTF	0.9916	0.7175	5	16
ZNF587-BAX	chr19	58367600	chr19	49464066	345	HLA-A32:01	RRPTQQGTVTF	0.9586	0.7563	5	16

Top

Potential FusionNeoAntigen Information of ZNF587-BAX in HLA II

ZNF587-BAX_58367600_49464066.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
ZNF587-BAX	chr19	58367600	chr19	49464066	345	DRB1-1002	QGTVTFEDVAVNFSQ	10	25
ZNF587-BAX	chr19	58367600	chr19	49464066	339	DRB1-1002	QGTVTFEDVAVNFSQ	10	25

Top

Fusion breakpoint peptide structures of ZNF587-BAX

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
4761	LALISSLGPVHQGA	ZNF587	BAX	chr19	58367600	chr19	49464066	265

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
8111	RPTQQGTVTFEDVA	ZNF587	BAX	chr19	58367600	chr19	49464066	345

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
8181	RRPTQGTVTFEDVA	ZNF587	BAX	chr19	58367600	chr19	49464066	339

Top

Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of ZNF587-BAX

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	4761	LALISSLGPVHQGA	-7.15543	-7.26883
HLA-B14:02	3BVN	4761	LALISSLGPVHQGA	-4.77435	-5.80965
HLA-B52:01	3W39	4761	LALISSLGPVHQGA	-6.80875	-6.92215
HLA-B52:01	3W39	4761	LALISSLGPVHQGA	-4.20386	-5.23916
HLA-A11:01	4UQ2	4761	LALISSLGPVHQGA	-7.5194	-8.5547
HLA-A11:01	4UQ2	4761	LALISSLGPVHQGA	-6.9601	-7.0735
HLA-A24:02	5HGA	4761	LALISSLGPVHQGA	-7.52403	-7.63743
HLA-A24:02	5HGA	4761	LALISSLGPVHQGA	-5.82433	-6.85963
HLA-B27:05	6PYJ	4761	LALISSLGPVHQGA	-3.28285	-4.31815
HLA-B44:05	3DX8	4761	LALISSLGPVHQGA	-5.91172	-6.94702
HLA-B44:05	3DX8	4761	LALISSLGPVHQGA	-4.24346	-4.35686
HLA-B14:02	3BVN	8111	RPTQQGTVTFEDVA	-7.15543	-7.26883
HLA-B14:02	3BVN	8111	RPTQQGTVTFEDVA	-4.77435	-5.80965
HLA-B52:01	3W39	8111	RPTQQGTVTFEDVA	-6.80875	-6.92215
HLA-B52:01	3W39	8111	RPTQQGTVTFEDVA	-4.20386	-5.23916
HLA-A11:01	4UQ2	8111	RPTQQGTVTFEDVA	-7.5194	-8.5547
HLA-A11:01	4UQ2	8111	RPTQQGTVTFEDVA	-6.9601	-7.0735
HLA-A24:02	5HGA	8111	RPTQQGTVTFEDVA	-7.52403	-7.63743
HLA-A24:02	5HGA	8111	RPTQQGTVTFEDVA	-5.82433	-6.85963
HLA-B27:05	6PYJ	8111	RPTQQGTVTFEDVA	-3.28285	-4.31815
HLA-B44:05	3DX8	8111	RPTQQGTVTFEDVA	-5.91172	-6.94702
HLA-B44:05	3DX8	8111	RPTQQGTVTFEDVA	-4.24346	-4.35686
HLA-B14:02	3BVN	8181	RRPTQGTVTFEDVA	-7.15543	-7.26883
HLA-B14:02	3BVN	8181	RRPTQGTVTFEDVA	-4.77435	-5.80965
HLA-B52:01	3W39	8181	RRPTQGTVTFEDVA	-6.80875	-6.92215
HLA-B52:01	3W39	8181	RRPTQGTVTFEDVA	-4.20386	-5.23916
HLA-A11:01	4UQ2	8181	RRPTQGTVTFEDVA	-7.5194	-8.5547
HLA-A11:01	4UQ2	8181	RRPTQGTVTFEDVA	-6.9601	-7.0735
HLA-A24:02	5HGA	8181	RRPTQGTVTFEDVA	-7.52403	-7.63743
HLA-A24:02	5HGA	8181	RRPTQGTVTFEDVA	-5.82433	-6.85963
HLA-B27:05	6PYJ	8181	RRPTQGTVTFEDVA	-3.28285	-4.31815
HLA-B44:05	3DX8	8181	RRPTQGTVTFEDVA	-5.91172	-6.94702
HLA-B44:05	3DX8	8181	RRPTQGTVTFEDVA	-4.24346	-4.35686

Top

Vaccine Design for the FusionNeoAntigens of ZNF587-BAX

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
ZNF587-BAX	chr19	58367600	chr19	49464066	11	20	SLGPVHQGA	CGCTGGGCCCTGTGCACCAAGGTGCCG
ZNF587-BAX	chr19	58367600	chr19	49464066	3	14	VPRRPTQQGTV	TAGAGAACCTGGCTCTCATATCCTCGCTGGGCC
ZNF587-BAX	chr19	58367600	chr19	49464066	4	14	VPRRPTQGTV	AGAACCTGGCTCTCATATCCTCGCTGGGCC
ZNF587-BAX	chr19	58367600	chr19	49464066	4	15	VPRRPTQGTVT	AGAACCTGGCTCTCATATCCTCGCTGGGCCCTG
ZNF587-BAX	chr19	58367600	chr19	49464066	5	14	RRPTQQGTV	ACCTGGCTCTCATATCCTCGCTGGGCC
ZNF587-BAX	chr19	58367600	chr19	49464066	5	16	RRPTQQGTVTF	ACCTGGCTCTCATATCCTCGCTGGGCCCTGTGC
ZNF587-BAX	chr19	58367600	chr19	49464066	6	16	RPTQQGTVTF	TGGCTCTCATATCCTCGCTGGGCCCTGTGC
ZNF587-BAX	chr19	58367600	chr19	49464066	6	16	RRPTQGTVTF	TGGCTCTCATATCCTCGCTGGGCCCTGTGC
ZNF587-BAX	chr19	58367600	chr19	49464066	7	16	ALISSLGPV	CTCTCATATCCTCGCTGGGCCCTGTGC
ZNF587-BAX	chr19	58367600	chr19	49464066	7	16	PTQQGTVTF	CTCTCATATCCTCGCTGGGCCCTGTGC
ZNF587-BAX	chr19	58367600	chr19	49464066	7	16	RPTQGTVTF	CTCTCATATCCTCGCTGGGCCCTGTGC
ZNF587-BAX	chr19	58367600	chr19	49464066	8	16	TQQGTVTF	TCATATCCTCGCTGGGCCCTGTGC

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
ZNF587-BAX	chr19	58367600	chr19	49464066	10	25	QGTVTFEDVAVNFSQ	CCTCGCTGGGCCCTGTGCACCAAGGTGCCGGAACTGATCAGAACC

Top

Information of the samples that have these potential fusion neoantigens of ZNF587-BAX

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
LUAD	ZNF587-BAX	chr19	58367600	ENST00000339656	chr19	49464066	ENST00000539787	TCGA-50-6591-01A
LUAD	ZNF587-BAX	chr19	58367600	ENST00000419854	chr19	49464066	ENST00000539787	TCGA-50-6591-01A
LUAD	ZNF587-BAX	chr19	58367600	ENST00000423137	chr19	49464066	ENST00000539787	TCGA-50-6591-01A

Top

Potential target of CAR-T therapy development for ZNF587-BAX

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

BAX

chr19:58367600

chr19:49464066

ENST00000293288

172_192

219.0

Transmembrane

Helical

Tgene

BAX

chr19:58367600

chr19:49464066

ENST00000345358

172_192

193.0

Transmembrane

Helical

Tgene

BAX

chr19:58367600

chr19:49464066

ENST00000354470

172_192

144.0

Transmembrane

Helical

Tgene

BAX

chr19:58367600

chr19:49464066

ENST00000391871

172_192

88.33333333333333

Transmembrane

Helical

Tgene

BAX

chr19:58367600

chr19:49464066

ENST00000415969

172_192

180.0

Transmembrane

Helical

Tgene

BAX

chr19:58367600

chr19:49464066

ENST00000539787

172_192

205.66666666666666

Transmembrane

Helical

Tgene

BAX

chr19:58367601

chr19:49464066

ENST00000293288

172_192

219.0

Transmembrane

Helical

Tgene

BAX

chr19:58367601

chr19:49464066

ENST00000345358

172_192

193.0

Transmembrane

Helical

Tgene

BAX

chr19:58367601

chr19:49464066

ENST00000354470

172_192

144.0

Transmembrane

Helical

Tgene

BAX

chr19:58367601

chr19:49464066

ENST00000391871

172_192

88.33333333333333

Transmembrane

Helical

Tgene

BAX

chr19:58367601

chr19:49464066

ENST00000415969

172_192

180.0

Transmembrane

Helical

Tgene

BAX

chr19:58367601

chr19:49464066

ENST00000539787

172_192

205.66666666666666

Transmembrane

Helical

Tgene

BAX

chr19:58367601

chr19:49464067

ENST00000293288

172_192

219.0

Transmembrane

Helical

Tgene

BAX

chr19:58367601

chr19:49464067

ENST00000345358

172_192

193.0

Transmembrane

Helical

Tgene

BAX

chr19:58367601

chr19:49464067

ENST00000354470

172_192

144.0

Transmembrane

Helical

Tgene

BAX

chr19:58367601

chr19:49464067

ENST00000391871

172_192

88.33333333333333

Transmembrane

Helical

Tgene

BAX

chr19:58367601

chr19:49464067

ENST00000415969

172_192

180.0

Transmembrane

Helical

Tgene

BAX

chr19:58367601

chr19:49464067

ENST00000539787

172_192

205.66666666666666

Transmembrane

Helical

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

Top

Related Drugs to ZNF587-BAX

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ZNF587-BAX

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)