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Fusion Protein:CACNA1C-DERA

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CACNA1C-DERA
	FusionPDB ID: 12299
	FusionGDB2.0 ID: 12299
		Hgene	Tgene
	Gene symbol	CACNA1C	DERA
	Gene ID	775	51071
	Gene name	calcium voltage-gated channel subunit alpha1 C	deoxyribose-phosphate aldolase
	Synonyms	CACH2\|CACN2\|CACNL1A1\|CCHL1A1\|CaV1.2\|LQT8\|TS\|TS. LQT8	CGI-26\|DEOC
	Cytomap	12p13.33	12p12.3
	Type of gene	protein-coding	protein-coding
	Description	voltage-dependent L-type calcium channel subunit alpha-1CDHPR, alpha-1 subunitcalcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac musclecalcium channel, cardic dihydropyridine-sensitive, alpha-1 subunitcalcium channel, voltage-dependent,	deoxyribose-phosphate aldolase2-deoxy-D-ribose 5-phosphate aldolase2-deoxyribose-5-phosphate aldolase homologdeoxyriboaldolasedeoxyribose-phosphate aldolase (putative)phosphodeoxyriboaldolaseputative deoxyribose-phosphate aldolase
	Modification date	20200315	20200313
	UniProtAcc	Q13936 Main function of 5'-partner protein: FUNCTION: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8392192, PubMed:7737988, PubMed:9087614, PubMed:9013606, PubMed:9607315, PubMed:12176756, PubMed:17071743, PubMed:11741969, PubMed:8099908, PubMed:12181424, PubMed:29078335, PubMed:29742403, PubMed:16299511, PubMed:20953164, PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506, PubMed:27218670, PubMed:23677916). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). {ECO:0000250\|UniProtKB:P15381, ECO:0000269\|PubMed:11741969, ECO:0000269\|PubMed:12176756, ECO:0000269\|PubMed:12181424, ECO:0000269\|PubMed:15454078, ECO:0000269\|PubMed:15863612, ECO:0000269\|PubMed:16299511, ECO:0000269\|PubMed:17071743, ECO:0000269\|PubMed:17224476, ECO:0000269\|PubMed:20953164, ECO:0000269\|PubMed:23677916, ECO:0000269\|PubMed:24728418, ECO:0000269\|PubMed:26253506, ECO:0000269\|PubMed:27218670, ECO:0000269\|PubMed:28119464, ECO:0000269\|PubMed:29078335, ECO:0000269\|PubMed:29742403, ECO:0000269\|PubMed:7737988, ECO:0000269\|PubMed:8099908, ECO:0000269\|PubMed:8392192, ECO:0000269\|PubMed:9013606, ECO:0000269\|PubMed:9087614, ECO:0000269\|PubMed:9607315, ECO:0000305}.; FUNCTION: (Microbial infection) Acts as a receptor for Influenzavirus (PubMed:29779930). May play a critical role in allowing virus entry when sialylated and expressed on lung tissues (PubMed:29779930). {ECO:0000269\|PubMed:29779930}.	Q9Y315 Main function of 5'-partner protein: FUNCTION: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation. {ECO:0000269\|PubMed:25229427}.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000491104, ENST00000327702, ENST00000335762, ENST00000344100, ENST00000347598, ENST00000399591, ENST00000399595, ENST00000399597, ENST00000399601, ENST00000399603, ENST00000399606, ENST00000399617, ENST00000399621, ENST00000399629, ENST00000399634, ENST00000399637, ENST00000399638, ENST00000399641, ENST00000399644, ENST00000399649, ENST00000399655, ENST00000402845, ENST00000406454, ENST00000480911,	ENST00000428559, ENST00000532964, ENST00000526530, ENST00000532573,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	19 X 16 X 8=2432	10 X 7 X 6=420
	# samples	19	9
	** MAII score	log2(19/2432*10)=-3.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/420*10)=-2.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: CACNA1C [Title/Abstract] AND DERA [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: CACNA1C [Title/Abstract] AND DERA [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CACNA1C(2622150)-DERA(16109870), # samples:3
Anticipated loss of major functional domain due to fusion event.	CACNA1C-DERA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CACNA1C-DERA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CACNA1C-DERA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CACNA1C-DERA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CACNA1C	GO:0007204	positive regulation of cytosolic calcium ion concentration	12130699
Hgene	CACNA1C	GO:0061577	calcium ion transmembrane transport via high voltage-gated calcium channel	15454078
Hgene	CACNA1C	GO:0070588	calcium ion transmembrane transport	15454078
Tgene	DERA	GO:0046121	deoxyribonucleoside catabolic process	9226884

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:2622150/chr12:16109870)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across CACNA1C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DERA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000335762	CACNA1C	chr12	2622150	+	ENST00000428559	DERA	chr12	16109870	+	3121	1655	265	2580	771
ENST00000335762	CACNA1C	chr12	2622150	+	ENST00000532964	DERA	chr12	16109870	+	2457	1655	265	2451	728
ENST00000399655	CACNA1C	chr12	2622150	+	ENST00000428559	DERA	chr12	16109870	+	3121	1655	265	2580	771
ENST00000399655	CACNA1C	chr12	2622150	+	ENST00000532964	DERA	chr12	16109870	+	2457	1655	265	2451	728
ENST00000480911	CACNA1C	chr12	2622150	+	ENST00000428559	DERA	chr12	16109870	+	2881	1415	25	2340	771
ENST00000480911	CACNA1C	chr12	2622150	+	ENST00000532964	DERA	chr12	16109870	+	2217	1415	25	2211	728
ENST00000399644	CACNA1C	chr12	2622150	+	ENST00000428559	DERA	chr12	16109870	+	2856	1390	0	2315	771
ENST00000399644	CACNA1C	chr12	2622150	+	ENST00000532964	DERA	chr12	16109870	+	2192	1390	0	2186	728
ENST00000344100	CACNA1C	chr12	2622150	+	ENST00000428559	DERA	chr12	16109870	+	2856	1390	0	2315	771
ENST00000344100	CACNA1C	chr12	2622150	+	ENST00000532964	DERA	chr12	16109870	+	2192	1390	0	2186	728
ENST00000399638	CACNA1C	chr12	2622150	+	ENST00000428559	DERA	chr12	16109870	+	2856	1390	0	2315	771
ENST00000399638	CACNA1C	chr12	2622150	+	ENST00000532964	DERA	chr12	16109870	+	2192	1390	0	2186	728
ENST00000399629	CACNA1C	chr12	2622150	+	ENST00000428559	DERA	chr12	16109870	+	2856	1390	0	2315	771
ENST00000399629	CACNA1C	chr12	2622150	+	ENST00000532964	DERA	chr12	16109870	+	2192	1390	0	2186	728
ENST00000399597	CACNA1C	chr12	2622150	+	ENST00000428559	DERA	chr12	16109870	+	2856	1390	0	2315	771
ENST00000399597	CACNA1C	chr12	2622150	+	ENST00000532964	DERA	chr12	16109870	+	2192	1390	0	2186	728
ENST00000327702	CACNA1C	chr12	2622150	+	ENST00000428559	DERA	chr12	16109870	+	2856	1390	0	2315	771
ENST00000327702	CACNA1C	chr12	2622150	+	ENST00000532964	DERA	chr12	16109870	+	2192	1390	0	2186	728
ENST00000399621	CACNA1C	chr12	2622150	+	ENST00000428559	DERA	chr12	16109870	+	2856	1390	0	2315	771
ENST00000399621	CACNA1C	chr12	2622150	+	ENST00000532964	DERA	chr12	16109870	+	2192	1390	0	2186	728
ENST00000399649	CACNA1C	chr12	2622150	+	ENST00000428559	DERA	chr12	16109870	+	2856	1390	0	2315	771
ENST00000399649	CACNA1C	chr12	2622150	+	ENST00000532964	DERA	chr12	16109870	+	2192	1390	0	2186	728
ENST00000399637	CACNA1C	chr12	2622150	+	ENST00000428559	DERA	chr12	16109870	+	2856	1390	0	2315	771
ENST00000399637	CACNA1C	chr12	2622150	+	ENST00000532964	DERA	chr12	16109870	+	2192	1390	0	2186	728
ENST00000402845	CACNA1C	chr12	2622150	+	ENST00000428559	DERA	chr12	16109870	+	2856	1390	0	2315	771
ENST00000402845	CACNA1C	chr12	2622150	+	ENST00000532964	DERA	chr12	16109870	+	2192	1390	0	2186	728
ENST00000399591	CACNA1C	chr12	2622150	+	ENST00000428559	DERA	chr12	16109870	+	2856	1390	0	2315	771
ENST00000399591	CACNA1C	chr12	2622150	+	ENST00000532964	DERA	chr12	16109870	+	2192	1390	0	2186	728
ENST00000399641	CACNA1C	chr12	2622150	+	ENST00000428559	DERA	chr12	16109870	+	2856	1390	0	2315	771
ENST00000399641	CACNA1C	chr12	2622150	+	ENST00000532964	DERA	chr12	16109870	+	2192	1390	0	2186	728
ENST00000347598	CACNA1C	chr12	2622150	+	ENST00000428559	DERA	chr12	16109870	+	2856	1390	0	2315	771
ENST00000347598	CACNA1C	chr12	2622150	+	ENST00000532964	DERA	chr12	16109870	+	2192	1390	0	2186	728
ENST00000399606	CACNA1C	chr12	2622150	+	ENST00000428559	DERA	chr12	16109870	+	2856	1390	0	2315	771
ENST00000399606	CACNA1C	chr12	2622150	+	ENST00000532964	DERA	chr12	16109870	+	2192	1390	0	2186	728
ENST00000399595	CACNA1C	chr12	2622150	+	ENST00000428559	DERA	chr12	16109870	+	2856	1390	0	2315	771
ENST00000399595	CACNA1C	chr12	2622150	+	ENST00000532964	DERA	chr12	16109870	+	2192	1390	0	2186	728
ENST00000399601	CACNA1C	chr12	2622150	+	ENST00000428559	DERA	chr12	16109870	+	2856	1390	0	2315	771
ENST00000399601	CACNA1C	chr12	2622150	+	ENST00000532964	DERA	chr12	16109870	+	2192	1390	0	2186	728
ENST00000399603	CACNA1C	chr12	2622150	+	ENST00000428559	DERA	chr12	16109870	+	2856	1390	0	2315	771
ENST00000399603	CACNA1C	chr12	2622150	+	ENST00000532964	DERA	chr12	16109870	+	2192	1390	0	2186	728
ENST00000399634	CACNA1C	chr12	2622150	+	ENST00000428559	DERA	chr12	16109870	+	2856	1390	0	2315	771
ENST00000399634	CACNA1C	chr12	2622150	+	ENST00000532964	DERA	chr12	16109870	+	2192	1390	0	2186	728
ENST00000399617	CACNA1C	chr12	2622150	+	ENST00000428559	DERA	chr12	16109870	+	2856	1390	0	2315	771
ENST00000399617	CACNA1C	chr12	2622150	+	ENST00000532964	DERA	chr12	16109870	+	2192	1390	0	2186	728
ENST00000406454	CACNA1C	chr12	2622150	+	ENST00000428559	DERA	chr12	16109870	+	2856	1390	0	2315	771
ENST00000406454	CACNA1C	chr12	2622150	+	ENST00000532964	DERA	chr12	16109870	+	2192	1390	0	2186	728
ENST00000335762	CACNA1C	chr12	2595428	+	ENST00000428559	DERA	chr12	16109870	+	2647	1181	265	2106	613
ENST00000335762	CACNA1C	chr12	2595428	+	ENST00000532964	DERA	chr12	16109870	+	1983	1181	265	1977	570
ENST00000399655	CACNA1C	chr12	2595428	+	ENST00000428559	DERA	chr12	16109870	+	2647	1181	265	2106	613
ENST00000399655	CACNA1C	chr12	2595428	+	ENST00000532964	DERA	chr12	16109870	+	1983	1181	265	1977	570
ENST00000480911	CACNA1C	chr12	2595428	+	ENST00000428559	DERA	chr12	16109870	+	2407	941	25	1866	613
ENST00000480911	CACNA1C	chr12	2595428	+	ENST00000532964	DERA	chr12	16109870	+	1743	941	25	1737	570
ENST00000399644	CACNA1C	chr12	2595428	+	ENST00000428559	DERA	chr12	16109870	+	2382	916	0	1841	613
ENST00000399644	CACNA1C	chr12	2595428	+	ENST00000532964	DERA	chr12	16109870	+	1718	916	0	1712	570
ENST00000344100	CACNA1C	chr12	2595428	+	ENST00000428559	DERA	chr12	16109870	+	2382	916	0	1841	613
ENST00000344100	CACNA1C	chr12	2595428	+	ENST00000532964	DERA	chr12	16109870	+	1718	916	0	1712	570
ENST00000399638	CACNA1C	chr12	2595428	+	ENST00000428559	DERA	chr12	16109870	+	2382	916	0	1841	613
ENST00000399638	CACNA1C	chr12	2595428	+	ENST00000532964	DERA	chr12	16109870	+	1718	916	0	1712	570
ENST00000399629	CACNA1C	chr12	2595428	+	ENST00000428559	DERA	chr12	16109870	+	2382	916	0	1841	613
ENST00000399629	CACNA1C	chr12	2595428	+	ENST00000532964	DERA	chr12	16109870	+	1718	916	0	1712	570
ENST00000399597	CACNA1C	chr12	2595428	+	ENST00000428559	DERA	chr12	16109870	+	2382	916	0	1841	613
ENST00000399597	CACNA1C	chr12	2595428	+	ENST00000532964	DERA	chr12	16109870	+	1718	916	0	1712	570
ENST00000327702	CACNA1C	chr12	2595428	+	ENST00000428559	DERA	chr12	16109870	+	2382	916	0	1841	613
ENST00000327702	CACNA1C	chr12	2595428	+	ENST00000532964	DERA	chr12	16109870	+	1718	916	0	1712	570
ENST00000399621	CACNA1C	chr12	2595428	+	ENST00000428559	DERA	chr12	16109870	+	2382	916	0	1841	613
ENST00000399621	CACNA1C	chr12	2595428	+	ENST00000532964	DERA	chr12	16109870	+	1718	916	0	1712	570
ENST00000399649	CACNA1C	chr12	2595428	+	ENST00000428559	DERA	chr12	16109870	+	2382	916	0	1841	613
ENST00000399649	CACNA1C	chr12	2595428	+	ENST00000532964	DERA	chr12	16109870	+	1718	916	0	1712	570
ENST00000399637	CACNA1C	chr12	2595428	+	ENST00000428559	DERA	chr12	16109870	+	2382	916	0	1841	613
ENST00000399637	CACNA1C	chr12	2595428	+	ENST00000532964	DERA	chr12	16109870	+	1718	916	0	1712	570
ENST00000402845	CACNA1C	chr12	2595428	+	ENST00000428559	DERA	chr12	16109870	+	2382	916	0	1841	613
ENST00000402845	CACNA1C	chr12	2595428	+	ENST00000532964	DERA	chr12	16109870	+	1718	916	0	1712	570
ENST00000399591	CACNA1C	chr12	2595428	+	ENST00000428559	DERA	chr12	16109870	+	2382	916	0	1841	613
ENST00000399591	CACNA1C	chr12	2595428	+	ENST00000532964	DERA	chr12	16109870	+	1718	916	0	1712	570
ENST00000399641	CACNA1C	chr12	2595428	+	ENST00000428559	DERA	chr12	16109870	+	2382	916	0	1841	613
ENST00000399641	CACNA1C	chr12	2595428	+	ENST00000532964	DERA	chr12	16109870	+	1718	916	0	1712	570
ENST00000347598	CACNA1C	chr12	2595428	+	ENST00000428559	DERA	chr12	16109870	+	2382	916	0	1841	613
ENST00000347598	CACNA1C	chr12	2595428	+	ENST00000532964	DERA	chr12	16109870	+	1718	916	0	1712	570
ENST00000399606	CACNA1C	chr12	2595428	+	ENST00000428559	DERA	chr12	16109870	+	2382	916	0	1841	613
ENST00000399606	CACNA1C	chr12	2595428	+	ENST00000532964	DERA	chr12	16109870	+	1718	916	0	1712	570
ENST00000399595	CACNA1C	chr12	2595428	+	ENST00000428559	DERA	chr12	16109870	+	2382	916	0	1841	613
ENST00000399595	CACNA1C	chr12	2595428	+	ENST00000532964	DERA	chr12	16109870	+	1718	916	0	1712	570
ENST00000399601	CACNA1C	chr12	2595428	+	ENST00000428559	DERA	chr12	16109870	+	2382	916	0	1841	613
ENST00000399601	CACNA1C	chr12	2595428	+	ENST00000532964	DERA	chr12	16109870	+	1718	916	0	1712	570
ENST00000399603	CACNA1C	chr12	2595428	+	ENST00000428559	DERA	chr12	16109870	+	2382	916	0	1841	613
ENST00000399603	CACNA1C	chr12	2595428	+	ENST00000532964	DERA	chr12	16109870	+	1718	916	0	1712	570
ENST00000399634	CACNA1C	chr12	2595428	+	ENST00000428559	DERA	chr12	16109870	+	2382	916	0	1841	613
ENST00000399634	CACNA1C	chr12	2595428	+	ENST00000532964	DERA	chr12	16109870	+	1718	916	0	1712	570
ENST00000399617	CACNA1C	chr12	2595428	+	ENST00000428559	DERA	chr12	16109870	+	2382	916	0	1841	613
ENST00000399617	CACNA1C	chr12	2595428	+	ENST00000532964	DERA	chr12	16109870	+	1718	916	0	1712	570
ENST00000406454	CACNA1C	chr12	2595428	+	ENST00000428559	DERA	chr12	16109870	+	2382	916	0	1841	613
ENST00000406454	CACNA1C	chr12	2595428	+	ENST00000532964	DERA	chr12	16109870	+	1718	916	0	1712	570

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000335762	ENST00000428559	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.003476047	0.9965239
ENST00000335762	ENST00000532964	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.007822551	0.9921774
ENST00000399655	ENST00000428559	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.003476047	0.9965239
ENST00000399655	ENST00000532964	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.007822551	0.9921774
ENST00000480911	ENST00000428559	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.003792614	0.99620736
ENST00000480911	ENST00000532964	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.008499939	0.9915001
ENST00000399644	ENST00000428559	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.003951768	0.9960483
ENST00000399644	ENST00000532964	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.009111079	0.99088895
ENST00000344100	ENST00000428559	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.003951768	0.9960483
ENST00000344100	ENST00000532964	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.009111079	0.99088895
ENST00000399638	ENST00000428559	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.003951768	0.9960483
ENST00000399638	ENST00000532964	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.009111079	0.99088895
ENST00000399629	ENST00000428559	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.003951768	0.9960483
ENST00000399629	ENST00000532964	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.009111079	0.99088895
ENST00000399597	ENST00000428559	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.003951768	0.9960483
ENST00000399597	ENST00000532964	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.009111079	0.99088895
ENST00000327702	ENST00000428559	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.003951768	0.9960483
ENST00000327702	ENST00000532964	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.009111079	0.99088895
ENST00000399621	ENST00000428559	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.003951768	0.9960483
ENST00000399621	ENST00000532964	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.009111079	0.99088895
ENST00000399649	ENST00000428559	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.003951768	0.9960483
ENST00000399649	ENST00000532964	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.009111079	0.99088895
ENST00000399637	ENST00000428559	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.003951768	0.9960483
ENST00000399637	ENST00000532964	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.009111079	0.99088895
ENST00000402845	ENST00000428559	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.003951768	0.9960483
ENST00000402845	ENST00000532964	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.009111079	0.99088895
ENST00000399591	ENST00000428559	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.003951768	0.9960483
ENST00000399591	ENST00000532964	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.009111079	0.99088895
ENST00000399641	ENST00000428559	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.003964947	0.99603504
ENST00000399641	ENST00000532964	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.009242802	0.99075717
ENST00000347598	ENST00000428559	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.003951768	0.9960483
ENST00000347598	ENST00000532964	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.009111079	0.99088895
ENST00000399606	ENST00000428559	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.003951768	0.9960483
ENST00000399606	ENST00000532964	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.009111079	0.99088895
ENST00000399595	ENST00000428559	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.003951768	0.9960483
ENST00000399595	ENST00000532964	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.009111079	0.99088895
ENST00000399601	ENST00000428559	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.003951768	0.9960483
ENST00000399601	ENST00000532964	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.009111079	0.99088895
ENST00000399603	ENST00000428559	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.003964947	0.99603504
ENST00000399603	ENST00000532964	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.009242802	0.99075717
ENST00000399634	ENST00000428559	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.003964947	0.99603504
ENST00000399634	ENST00000532964	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.009242802	0.99075717
ENST00000399617	ENST00000428559	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.003964947	0.99603504
ENST00000399617	ENST00000532964	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.009242802	0.99075717
ENST00000406454	ENST00000428559	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.003964947	0.99603504
ENST00000406454	ENST00000532964	CACNA1C	chr12	2622150	+	DERA	chr12	16109870	+	0.009242802	0.99075717
ENST00000335762	ENST00000428559	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.004371075	0.99562895
ENST00000335762	ENST00000532964	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.007596398	0.9924036
ENST00000399655	ENST00000428559	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.004371075	0.99562895
ENST00000399655	ENST00000532964	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.007596398	0.9924036
ENST00000480911	ENST00000428559	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.004880865	0.9951192
ENST00000480911	ENST00000532964	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.009186174	0.9908138
ENST00000399644	ENST00000428559	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.005162625	0.99483734
ENST00000399644	ENST00000532964	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.010013661	0.98998636
ENST00000344100	ENST00000428559	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.005162625	0.99483734
ENST00000344100	ENST00000532964	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.010013661	0.98998636
ENST00000399638	ENST00000428559	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.005162625	0.99483734
ENST00000399638	ENST00000532964	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.010013661	0.98998636
ENST00000399629	ENST00000428559	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.005162625	0.99483734
ENST00000399629	ENST00000532964	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.010013661	0.98998636
ENST00000399597	ENST00000428559	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.005162625	0.99483734
ENST00000399597	ENST00000532964	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.010013661	0.98998636
ENST00000327702	ENST00000428559	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.005162625	0.99483734
ENST00000327702	ENST00000532964	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.010013661	0.98998636
ENST00000399621	ENST00000428559	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.005162625	0.99483734
ENST00000399621	ENST00000532964	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.010013661	0.98998636
ENST00000399649	ENST00000428559	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.005162625	0.99483734
ENST00000399649	ENST00000532964	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.010013661	0.98998636
ENST00000399637	ENST00000428559	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.005162625	0.99483734
ENST00000399637	ENST00000532964	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.010013661	0.98998636
ENST00000402845	ENST00000428559	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.005162625	0.99483734
ENST00000402845	ENST00000532964	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.010013661	0.98998636
ENST00000399591	ENST00000428559	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.005162625	0.99483734
ENST00000399591	ENST00000532964	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.010013661	0.98998636
ENST00000399641	ENST00000428559	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.005162625	0.99483734
ENST00000399641	ENST00000532964	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.010013661	0.98998636
ENST00000347598	ENST00000428559	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.005162625	0.99483734
ENST00000347598	ENST00000532964	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.010013661	0.98998636
ENST00000399606	ENST00000428559	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.005162625	0.99483734
ENST00000399606	ENST00000532964	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.010013661	0.98998636
ENST00000399595	ENST00000428559	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.005162625	0.99483734
ENST00000399595	ENST00000532964	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.010013661	0.98998636
ENST00000399601	ENST00000428559	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.005162625	0.99483734
ENST00000399601	ENST00000532964	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.010013661	0.98998636
ENST00000399603	ENST00000428559	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.005162625	0.99483734
ENST00000399603	ENST00000532964	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.010013661	0.98998636
ENST00000399634	ENST00000428559	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.005162625	0.99483734
ENST00000399634	ENST00000532964	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.010013661	0.98998636
ENST00000399617	ENST00000428559	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.005162625	0.99483734
ENST00000399617	ENST00000532964	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.010013661	0.98998636
ENST00000406454	ENST00000428559	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.005162625	0.99483734
ENST00000406454	ENST00000532964	CACNA1C	chr12	2595428	+	DERA	chr12	16109870	+	0.010013661	0.98998636

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for CACNA1C-DERA

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
CACNA1C	chr12	2595428	DERA	chr12	16109870	1181	305	KMHKTCYNQEGIADLSWISKIQVNHP
CACNA1C	chr12	2595428	DERA	chr12	16109870	916	305	KMHKTCYNQEGIADLSWISKIQVNHP
CACNA1C	chr12	2595428	DERA	chr12	16109870	941	305	KMHKTCYNQEGIADLSWISKIQVNHP
CACNA1C	chr12	2622150	DERA	chr12	16109870	1390	464	EDEGMDEEKPRNNLSWISKIQVNHPA
CACNA1C	chr12	2622150	DERA	chr12	16109870	1415	464	EDEGMDEEKPRNNLSWISKIQVNHPA
CACNA1C	chr12	2622150	DERA	chr12	16109870	1655	464	EDEGMDEEKPRNNLSWISKIQVNHPA

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Potential FusionNeoAntigen Information of CACNA1C-DERA in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

CACNA1C-DERA_2595428_16109870.msa
CACNA1C-DERA_2622150_16109870.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	HLA-B44:03	QEGIADLSW	0.9989	0.9894	8	17
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	HLA-B44:02	QEGIADLSW	0.9981	0.6146	8	17
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	HLA-B44:05	QEGIADLSW	0.9935	0.8227	8	17
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	HLA-B13:01	ADLSWISKI	0.7744	0.8761	12	21
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	HLA-B52:01	ADLSWISKI	0.7426	0.7005	12	21
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	HLA-B44:03	NQEGIADLSW	0.9194	0.982	7	17
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	HLA-B44:08	QEGIADLSW	0.9973	0.727	8	17
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	HLA-B44:09	QEGIADLSW	0.9946	0.7353	8	17
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	HLA-B44:10	QEGIADLSW	0.8158	0.8193	8	17
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	HLA-B44:07	QEGIADLSW	0.9989	0.9894	8	17
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	HLA-B44:13	QEGIADLSW	0.9989	0.9894	8	17
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	HLA-B44:26	QEGIADLSW	0.9989	0.9894	8	17
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	HLA-B44:22	QEGIADLSW	0.9981	0.6146	8	17
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	HLA-B44:13	NQEGIADLSW	0.9194	0.982	7	17
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	HLA-B44:26	NQEGIADLSW	0.9194	0.982	7	17
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	HLA-B44:07	NQEGIADLSW	0.9194	0.982	7	17
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	HLA-B15:13	NQEGIADLSW	0.7126	0.7807	7	17
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	HLA-B18:01	DEEKPRNNL	0.9269	0.9717	5	14
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	HLA-B44:03	EEKPRNNLSW	0.9752	0.9364	6	16
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	HLA-B44:03	DEEKPRNNLSW	0.9997	0.9523	5	16
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	HLA-B39:08	DEEKPRNNL	0.6784	0.7436	5	14
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	HLA-B18:03	EEKPRNNL	0.9649	0.966	6	14
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	HLA-A30:01	RNNLSWISK	0.9853	0.7798	10	19
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	HLA-B18:05	DEEKPRNNL	0.9269	0.9717	5	14
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	HLA-B18:08	DEEKPRNNL	0.917	0.9216	5	14
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	HLA-B18:06	DEEKPRNNL	0.9142	0.9717	5	14
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	HLA-B18:03	DEEKPRNNL	0.9108	0.9683	5	14
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	HLA-B41:03	DEEKPRNNL	0.6743	0.5048	5	14
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	HLA-B18:11	DEEKPRNNL	0.6231	0.9437	5	14
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	HLA-B39:11	DEEKPRNNL	0.6154	0.6878	5	14
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	HLA-B44:07	EEKPRNNLSW	0.9752	0.9364	6	16
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	HLA-B44:26	EEKPRNNLSW	0.9752	0.9364	6	16
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	HLA-B44:13	EEKPRNNLSW	0.9752	0.9364	6	16
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	HLA-B44:07	DEEKPRNNLSW	0.9997	0.9523	5	16
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	HLA-B44:26	DEEKPRNNLSW	0.9997	0.9523	5	16
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	HLA-B44:13	DEEKPRNNLSW	0.9997	0.9523	5	16

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Potential FusionNeoAntigen Information of CACNA1C-DERA in HLA II

CACNA1C-DERA_2595428_16109870.msa
CACNA1C-DERA_2622150_16109870.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1117	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1152	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1377	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1401	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1401	GIADLSWISKIQVNH	10	25
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1404	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1404	GIADLSWISKIQVNH	10	25
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1405	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1408	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1411	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1418	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1423	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1426	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1426	GIADLSWISKIQVNH	10	25
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1428	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1428	GIADLSWISKIQVNH	10	25
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1431	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1432	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1434	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1435	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1435	GIADLSWISKIQVNH	10	25
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1438	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1439	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1443	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1445	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1450	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1454	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1454	GIADLSWISKIQVNH	10	25
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1455	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1456	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1458	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1458	GIADLSWISKIQVNH	10	25
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1459	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1460	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1460	GIADLSWISKIQVNH	10	25
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1461	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1461	GIADLSWISKIQVNH	10	25
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1462	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1464	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1465	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1468	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1470	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1471	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1471	GIADLSWISKIQVNH	10	25
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1472	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1475	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1481	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1482	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1486	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1486	GIADLSWISKIQVNH	10	25
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1487	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1487	GIADLSWISKIQVNH	10	25
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1488	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1488	GIADLSWISKIQVNH	10	25
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1490	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1490	GIADLSWISKIQVNH	10	25
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1491	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1496	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1497	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1497	GIADLSWISKIQVNH	10	25
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1499	IADLSWISKIQVNHP	11	26
CACNA1C-DERA	chr12	2595428	chr12	16109870	916	DRB1-1499	GIADLSWISKIQVNH	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1113	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1113	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1117	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1117	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1152	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1152	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1189	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-13100	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1331	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1343	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1346	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1354	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1377	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1377	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1401	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1401	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1401	KPRNNLSWISKIQVN	8	23
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1404	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1404	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1404	KPRNNLSWISKIQVN	8	23
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1405	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1405	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1406	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1407	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1408	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1408	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1411	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1411	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1416	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1418	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1418	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1420	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1423	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1423	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1426	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1426	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1426	KPRNNLSWISKIQVN	8	23
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1428	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1428	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1428	KPRNNLSWISKIQVN	8	23
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1431	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1431	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1432	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1432	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1433	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1434	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1434	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1435	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1435	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1435	KPRNNLSWISKIQVN	8	23
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1438	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1438	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1439	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1439	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1443	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1443	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1445	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1445	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1449	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1450	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1450	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1454	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1454	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1454	KPRNNLSWISKIQVN	8	23
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1455	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1455	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1456	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1456	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1458	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1458	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1458	KPRNNLSWISKIQVN	8	23
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1459	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1459	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1460	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1460	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1460	KPRNNLSWISKIQVN	8	23
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1461	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1461	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1461	KPRNNLSWISKIQVN	8	23
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1462	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1462	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1462	KPRNNLSWISKIQVN	8	23
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1464	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1464	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1465	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1465	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1468	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1468	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1470	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1470	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1471	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1471	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1471	KPRNNLSWISKIQVN	8	23
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1472	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1472	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1473	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1474	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1475	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1475	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1475	KPRNNLSWISKIQVN	8	23
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1481	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1481	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1482	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1482	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1483	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1486	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1486	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1486	KPRNNLSWISKIQVN	8	23
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1487	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1487	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1487	KPRNNLSWISKIQVN	8	23
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1488	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1488	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1488	KPRNNLSWISKIQVN	8	23
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1490	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1490	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1490	KPRNNLSWISKIQVN	8	23
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1491	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1491	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1495	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1495	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1496	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1496	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1497	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1497	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1497	KPRNNLSWISKIQVN	8	23
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1499	RNNLSWISKIQVNHP	10	25
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1499	PRNNLSWISKIQVNH	9	24
CACNA1C-DERA	chr12	2622150	chr12	16109870	1390	DRB1-1499	KPRNNLSWISKIQVN	8	23

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Fusion breakpoint peptide structures of CACNA1C-DERA

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
1676	EEKPRNNLSWISKI	CACNA1C	DERA	chr12	2622150	chr12	16109870	1390

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
10751	YNQEGIADLSWISK	CACNA1C	DERA	chr12	2595428	chr12	16109870	916

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of CACNA1C-DERA

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	1676	EEKPRNNLSWISKI	-7.15543	-7.26883
HLA-B14:02	3BVN	1676	EEKPRNNLSWISKI	-4.77435	-5.80965
HLA-B52:01	3W39	1676	EEKPRNNLSWISKI	-6.80875	-6.92215
HLA-B52:01	3W39	1676	EEKPRNNLSWISKI	-4.20386	-5.23916
HLA-A11:01	4UQ2	1676	EEKPRNNLSWISKI	-7.5194	-8.5547
HLA-A11:01	4UQ2	1676	EEKPRNNLSWISKI	-6.9601	-7.0735
HLA-A24:02	5HGA	1676	EEKPRNNLSWISKI	-7.52403	-7.63743
HLA-A24:02	5HGA	1676	EEKPRNNLSWISKI	-5.82433	-6.85963
HLA-B27:05	6PYJ	1676	EEKPRNNLSWISKI	-3.28285	-4.31815
HLA-B44:05	3DX8	1676	EEKPRNNLSWISKI	-5.91172	-6.94702
HLA-B44:05	3DX8	1676	EEKPRNNLSWISKI	-4.24346	-4.35686
HLA-B14:02	3BVN	10751	YNQEGIADLSWISK	-7.15543	-7.26883
HLA-B14:02	3BVN	10751	YNQEGIADLSWISK	-4.77435	-5.80965
HLA-B52:01	3W39	10751	YNQEGIADLSWISK	-6.80875	-6.92215
HLA-B52:01	3W39	10751	YNQEGIADLSWISK	-4.20386	-5.23916
HLA-A11:01	4UQ2	10751	YNQEGIADLSWISK	-7.5194	-8.5547
HLA-A11:01	4UQ2	10751	YNQEGIADLSWISK	-6.9601	-7.0735
HLA-A24:02	5HGA	10751	YNQEGIADLSWISK	-7.52403	-7.63743
HLA-A24:02	5HGA	10751	YNQEGIADLSWISK	-5.82433	-6.85963
HLA-B27:05	6PYJ	10751	YNQEGIADLSWISK	-3.28285	-4.31815
HLA-B44:05	3DX8	10751	YNQEGIADLSWISK	-5.91172	-6.94702
HLA-B44:05	3DX8	10751	YNQEGIADLSWISK	-4.24346	-4.35686

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Vaccine Design for the FusionNeoAntigens of CACNA1C-DERA

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
CACNA1C-DERA	chr12	2595428	chr12	16109870	12	21	ADLSWISKI	CAGACCTTAGCTGGATCTCCAAAATAC
CACNA1C-DERA	chr12	2595428	chr12	16109870	7	17	NQEGIADLSW	ACCAGGAGGGCATAGCAGACCTTAGCTGGA
CACNA1C-DERA	chr12	2595428	chr12	16109870	8	17	QEGIADLSW	AGGAGGGCATAGCAGACCTTAGCTGGA
CACNA1C-DERA	chr12	2622150	chr12	16109870	10	19	RNNLSWISK	CCCGAAACAACCTTAGCTGGATCTCCA
CACNA1C-DERA	chr12	2622150	chr12	16109870	5	14	DEEKPRNNL	TGGATGAGGAGAAGCCCCGAAACAACC
CACNA1C-DERA	chr12	2622150	chr12	16109870	5	16	DEEKPRNNLSW	TGGATGAGGAGAAGCCCCGAAACAACCTTAGCT
CACNA1C-DERA	chr12	2622150	chr12	16109870	6	14	EEKPRNNL	ATGAGGAGAAGCCCCGAAACAACC
CACNA1C-DERA	chr12	2622150	chr12	16109870	6	16	EEKPRNNLSW	ATGAGGAGAAGCCCCGAAACAACCTTAGCT

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
CACNA1C-DERA	chr12	2595428	chr12	16109870	10	25	GIADLSWISKIQVNH	GCATAGCAGACCTTAGCTGGATCTCCAAAATACAAGTGAATCACC
CACNA1C-DERA	chr12	2595428	chr12	16109870	11	26	IADLSWISKIQVNHP	TAGCAGACCTTAGCTGGATCTCCAAAATACAAGTGAATCACCCGG
CACNA1C-DERA	chr12	2622150	chr12	16109870	10	25	RNNLSWISKIQVNHP	CCCGAAACAACCTTAGCTGGATCTCCAAAATACAAGTGAATCACC
CACNA1C-DERA	chr12	2622150	chr12	16109870	8	23	KPRNNLSWISKIQVN	AGAAGCCCCGAAACAACCTTAGCTGGATCTCCAAAATACAAGTGA
CACNA1C-DERA	chr12	2622150	chr12	16109870	9	24	PRNNLSWISKIQVNH	AGCCCCGAAACAACCTTAGCTGGATCTCCAAAATACAAGTGAATC

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Information of the samples that have these potential fusion neoantigens of CACNA1C-DERA

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
SKCM	CACNA1C-DERA	chr12	2595428	ENST00000327702	chr12	16109870	ENST00000428559	TCGA-EE-A2MR-06A
SKCM	CACNA1C-DERA	chr12	2622150	ENST00000327702	chr12	16109870	ENST00000428559	TCGA-EE-A2MR-06A

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Potential target of CAR-T therapy development for CACNA1C-DERA

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000327702

351_372

463

2174.0

Intramembrane

Pore-forming

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000344100

351_372

463

2180.0

Intramembrane

Pore-forming

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000347598

351_372

463

2187.0

Intramembrane

Pore-forming

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399591

351_372

463

2147.0

Intramembrane

Pore-forming

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399595

351_372

463

2147.0

Intramembrane

Pore-forming

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399597

351_372

463

2139.0

Intramembrane

Pore-forming

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399601

351_372

463

2139.0

Intramembrane

Pore-forming

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399603

351_372

463

2139.0

Intramembrane

Pore-forming

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399606

351_372

463

2159.0

Intramembrane

Pore-forming

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399617

351_372

463

2174.0

Intramembrane

Pore-forming

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399621

351_372

463

2158.0

Intramembrane

Pore-forming

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399629

351_372

463

2156.0

Intramembrane

Pore-forming

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399637

351_372

463

2158.0

Intramembrane

Pore-forming

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399638

351_372

463

2167.0

Intramembrane

Pore-forming

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399641

351_372

463

2139.0

Intramembrane

Pore-forming

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399644

351_372

463

2139.0

Intramembrane

Pore-forming

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399649

351_372

463

2145.0

Intramembrane

Pore-forming

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399655

351_372

463

2139.0

Intramembrane

Pore-forming

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000402845

351_372

463

2158.0

Intramembrane

Pore-forming

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000327702

125_143

305

2174.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000327702

159_179

305

2174.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000327702

189_209

305

2174.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000327702

233_251

305

2174.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000327702

269_290

305

2174.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000344100

125_143

305

2180.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000344100

159_179

305

2180.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000344100

189_209

305

2180.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000344100

233_251

305

2180.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000344100

269_290

305

2180.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000347598

125_143

305

2187.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000347598

159_179

305

2187.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000347598

189_209

305

2187.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000347598

233_251

305

2187.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000347598

269_290

305

2187.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399591

125_143

305

2147.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399591

159_179

305

2147.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399591

189_209

305

2147.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399591

233_251

305

2147.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399591

269_290

305

2147.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399595

125_143

305

2147.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399595

159_179

305

2147.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399595

189_209

305

2147.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399595

233_251

305

2147.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399595

269_290

305

2147.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399597

125_143

305

2139.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399597

159_179

305

2139.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399597

189_209

305

2139.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399597

233_251

305

2139.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399597

269_290

305

2139.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399601

125_143

305

2139.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399601

159_179

305

2139.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399601

189_209

305

2139.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399601

233_251

305

2139.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399601

269_290

305

2139.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399603

125_143

305

2139.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399603

159_179

305

2139.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399603

189_209

305

2139.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399603

233_251

305

2139.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399603

269_290

305

2139.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399606

125_143

305

2159.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399606

159_179

305

2159.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399606

189_209

305

2159.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399606

233_251

305

2159.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399606

269_290

305

2159.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399617

125_143

305

2174.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399617

159_179

305

2174.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399617

189_209

305

2174.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399617

233_251

305

2174.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399617

269_290

305

2174.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399621

125_143

305

2158.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399621

159_179

305

2158.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399621

189_209

305

2158.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399621

233_251

305

2158.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399621

269_290

305

2158.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399629

125_143

305

2156.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399629

159_179

305

2156.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399629

189_209

305

2156.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399629

233_251

305

2156.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399629

269_290

305

2156.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399637

125_143

305

2158.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399637

159_179

305

2158.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399637

189_209

305

2158.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399637

233_251

305

2158.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399637

269_290

305

2158.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399638

125_143

305

2167.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399638

159_179

305

2167.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399638

189_209

305

2167.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399638

233_251

305

2167.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399638

269_290

305

2167.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399641

125_143

305

2139.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399641

159_179

305

2139.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399641

189_209

305

2139.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399641

233_251

305

2139.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399641

269_290

305

2139.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399644

125_143

305

2139.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399644

159_179

305

2139.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399644

189_209

305

2139.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399644

233_251

305

2139.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399644

269_290

305

2139.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399649

125_143

305

2145.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399649

159_179

305

2145.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399649

189_209

305

2145.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399649

233_251

305

2145.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399649

269_290

305

2145.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399655

125_143

305

2139.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399655

159_179

305

2139.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399655

189_209

305

2139.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399655

233_251

305

2139.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000399655

269_290

305

2139.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000402845

125_143

305

2158.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000402845

159_179

305

2158.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000402845

189_209

305

2158.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000402845

233_251

305

2158.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2595428

chr12:16109870

ENST00000402845

269_290

305

2158.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000327702

125_143

463

2174.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000327702

159_179

463

2174.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000327702

189_209

463

2174.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000327702

233_251

463

2174.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000327702

269_290

463

2174.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000327702

381_401

463

2174.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000344100

125_143

463

2180.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000344100

159_179

463

2180.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000344100

189_209

463

2180.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000344100

233_251

463

2180.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000344100

269_290

463

2180.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000344100

381_401

463

2180.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000347598

125_143

463

2187.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000347598

159_179

463

2187.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000347598

189_209

463

2187.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000347598

233_251

463

2187.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000347598

269_290

463

2187.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000347598

381_401

463

2187.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399591

125_143

463

2147.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399591

159_179

463

2147.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399591

189_209

463

2147.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399591

233_251

463

2147.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399591

269_290

463

2147.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399591

381_401

463

2147.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399595

125_143

463

2147.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399595

159_179

463

2147.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399595

189_209

463

2147.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399595

233_251

463

2147.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399595

269_290

463

2147.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399595

381_401

463

2147.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399597

125_143

463

2139.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399597

159_179

463

2139.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399597

189_209

463

2139.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399597

233_251

463

2139.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399597

269_290

463

2139.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399597

381_401

463

2139.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399601

125_143

463

2139.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399601

159_179

463

2139.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399601

189_209

463

2139.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399601

233_251

463

2139.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399601

269_290

463

2139.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399601

381_401

463

2139.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399603

125_143

463

2139.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399603

159_179

463

2139.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399603

189_209

463

2139.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399603

233_251

463

2139.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399603

269_290

463

2139.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399603

381_401

463

2139.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399606

125_143

463

2159.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399606

159_179

463

2159.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399606

189_209

463

2159.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399606

233_251

463

2159.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399606

269_290

463

2159.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399606

381_401

463

2159.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399617

125_143

463

2174.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399617

159_179

463

2174.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399617

189_209

463

2174.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399617

233_251

463

2174.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399617

269_290

463

2174.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399617

381_401

463

2174.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399621

125_143

463

2158.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399621

159_179

463

2158.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399621

189_209

463

2158.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399621

233_251

463

2158.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399621

269_290

463

2158.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399621

381_401

463

2158.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399629

125_143

463

2156.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399629

159_179

463

2156.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399629

189_209

463

2156.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399629

233_251

463

2156.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399629

269_290

463

2156.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399629

381_401

463

2156.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399637

125_143

463

2158.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399637

159_179

463

2158.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399637

189_209

463

2158.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399637

233_251

463

2158.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399637

269_290

463

2158.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399637

381_401

463

2158.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399638

125_143

463

2167.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399638

159_179

463

2167.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399638

189_209

463

2167.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399638

233_251

463

2167.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399638

269_290

463

2167.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399638

381_401

463

2167.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399641

125_143

463

2139.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399641

159_179

463

2139.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399641

189_209

463

2139.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399641

233_251

463

2139.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399641

269_290

463

2139.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399641

381_401

463

2139.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399644

125_143

463

2139.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399644

159_179

463

2139.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399644

189_209

463

2139.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399644

233_251

463

2139.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399644

269_290

463

2139.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399644

381_401

463

2139.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399649

125_143

463

2145.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399649

159_179

463

2145.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399649

189_209

463

2145.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399649

233_251

463

2145.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399649

269_290

463

2145.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399649

381_401

463

2145.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399655

125_143

463

2139.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399655

159_179

463

2139.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399655

189_209

463

2139.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399655

233_251

463

2139.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399655

269_290

463

2139.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000399655

381_401

463

2139.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000402845

125_143

463

2158.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000402845

159_179

463

2158.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000402845

189_209

463

2158.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000402845

233_251

463

2158.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000402845

269_290

463

2158.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1C

chr12:2622150

chr12:16109870

ENST00000402845

381_401

463

2158.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

Top

Related Drugs to CACNA1C-DERA

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to CACNA1C-DERA

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)