Home

Download

Statistics

Examples

Help

Contact

Fusion Protein:CACNA1G-MED24

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CACNA1G-MED24
	FusionPDB ID: 12335
	FusionGDB2.0 ID: 12335
		Hgene	Tgene
	Gene symbol	CACNA1G	MED24
	Gene ID	8913	9862
	Gene name	calcium voltage-gated channel subunit alpha1 G	mediator complex subunit 24
	Synonyms	Ca(V)T.1\|Cav3.1\|NBR13\|SCA42\|SCA42ND	ARC100\|CRSP100\|CRSP4\|DRIP100\|MED5\|THRAP4\|TRAP100
	Cytomap	17q21.33	17q21.1
	Type of gene	protein-coding	protein-coding
	Description	voltage-dependent T-type calcium channel subunit alpha-1Gcalcium channel, voltage-dependent, T type, alpha 1G subunitcav3.1cvoltage-dependent T-type calcium channel alpha 1G subunitvoltage-dependent calcium channel alpha 1G subunitvoltage-gated calci	mediator of RNA polymerase II transcription subunit 24CRSP complex subunit 4activator-recruited cofactor 100 kDa componentcofactor required for Sp1 transcriptional activation subunit 4cofactor required for Sp1 transcriptional activation, subunit 4, 10
	Modification date	20200313	20200313
	UniProtAcc	O43497 Main function of 5'-partner protein: FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. {ECO:0000269\|PubMed:10648811, ECO:0000269\|PubMed:10692398, ECO:0000269\|PubMed:26456284, ECO:0000269\|PubMed:26715324, ECO:0000269\|PubMed:29878067}.	O75448 Main function of 5'-partner protein: FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269\|PubMed:12218053, ECO:0000269\|PubMed:16595664}.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000352832, ENST00000354983, ENST00000358244, ENST00000359106, ENST00000360761, ENST00000416767, ENST00000429973, ENST00000442258, ENST00000502264, ENST00000503485, ENST00000505165, ENST00000507336, ENST00000507510, ENST00000507609, ENST00000507896, ENST00000510115, ENST00000510366, ENST00000512389, ENST00000513689, ENST00000513964, ENST00000514079, ENST00000514181, ENST00000514717, ENST00000515165, ENST00000515411, ENST00000515765,	ENST00000479829, ENST00000356271, ENST00000394126, ENST00000394127, ENST00000394128, ENST00000501516,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 6 X 4=168	16 X 15 X 7=1680
	# samples	6	23
	** MAII score	log2(6/168*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(23/1680*10)=-2.86875546672175 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: CACNA1G [Title/Abstract] AND MED24 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: CACNA1G [Title/Abstract] AND MED24 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CACNA1G(48655925)-MED24(38182584), # samples:2
Anticipated loss of major functional domain due to fusion event.	CACNA1G-MED24 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CACNA1G-MED24 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CACNA1G-MED24 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CACNA1G-MED24 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CACNA1G-MED24 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CACNA1G-MED24 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. CACNA1G-MED24 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. CACNA1G-MED24 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CACNA1G	GO:0042391	regulation of membrane potential	21084288
Hgene	CACNA1G	GO:0070509	calcium ion import	21084288
Hgene	CACNA1G	GO:0070588	calcium ion transmembrane transport	26456284\|26715324
Tgene	MED24	GO:0006367	transcription initiation from RNA polymerase II promoter	12218053
Tgene	MED24	GO:0045893	positive regulation of transcription, DNA-templated	10198638

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:48655925/chr17:38182584)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across CACNA1G (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MED24 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000360761	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	4286	2693	317	3853	1178
ENST00000360761	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	4285	2693	317	3853	1178
ENST00000360761	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	4281	2693	317	3853	1178
ENST00000360761	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	4275	2693	317	3853	1178
ENST00000360761	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3854	2693	317	3853	1179
ENST00000354983	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	4266	2673	297	3833	1178
ENST00000354983	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	4265	2673	297	3833	1178
ENST00000354983	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	4261	2673	297	3833	1178
ENST00000354983	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	4255	2673	297	3833	1178
ENST00000354983	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3834	2673	297	3833	1178
ENST00000352832	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	4266	2673	297	3833	1178
ENST00000352832	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	4265	2673	297	3833	1178
ENST00000352832	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	4261	2673	297	3833	1178
ENST00000352832	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	4255	2673	297	3833	1178
ENST00000352832	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3834	2673	297	3833	1178
ENST00000442258	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	4069	2476	100	3636	1178
ENST00000442258	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	4068	2476	100	3636	1178
ENST00000442258	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	4064	2476	100	3636	1178
ENST00000442258	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	4058	2476	100	3636	1178
ENST00000442258	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3637	2476	100	3636	1179
ENST00000416767	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	3922	2329	28	3489	1153
ENST00000416767	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	3921	2329	28	3489	1153
ENST00000416767	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	3917	2329	28	3489	1153
ENST00000416767	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	3911	2329	28	3489	1153
ENST00000416767	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3490	2329	28	3489	1154
ENST00000502264	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	3894	2301	0	3461	1153
ENST00000502264	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	3893	2301	0	3461	1153
ENST00000502264	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	3889	2301	0	3461	1153
ENST00000502264	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	3883	2301	0	3461	1153
ENST00000502264	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3462	2301	0	3461	1153
ENST00000515411	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	3894	2301	0	3461	1153
ENST00000515411	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	3893	2301	0	3461	1153
ENST00000515411	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	3889	2301	0	3461	1153
ENST00000515411	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	3883	2301	0	3461	1153
ENST00000515411	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3462	2301	0	3461	1153
ENST00000510115	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	3894	2301	0	3461	1153
ENST00000510115	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	3893	2301	0	3461	1153
ENST00000510115	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	3889	2301	0	3461	1153
ENST00000510115	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	3883	2301	0	3461	1153
ENST00000510115	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3462	2301	0	3461	1153
ENST00000503485	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	3894	2301	0	3461	1153
ENST00000503485	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	3893	2301	0	3461	1153
ENST00000503485	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	3889	2301	0	3461	1153
ENST00000503485	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	3883	2301	0	3461	1153
ENST00000503485	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3462	2301	0	3461	1153
ENST00000515165	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	3894	2301	0	3461	1153
ENST00000515165	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	3893	2301	0	3461	1153
ENST00000515165	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	3889	2301	0	3461	1153
ENST00000515165	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	3883	2301	0	3461	1153
ENST00000515165	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3462	2301	0	3461	1153
ENST00000507510	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	3894	2301	0	3461	1153
ENST00000507510	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	3893	2301	0	3461	1153
ENST00000507510	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	3889	2301	0	3461	1153
ENST00000507510	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	3883	2301	0	3461	1153
ENST00000507510	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3462	2301	0	3461	1153
ENST00000514181	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	3894	2301	0	3461	1153
ENST00000514181	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	3893	2301	0	3461	1153
ENST00000514181	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	3889	2301	0	3461	1153
ENST00000514181	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	3883	2301	0	3461	1153
ENST00000514181	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3462	2301	0	3461	1153
ENST00000515765	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	3894	2301	0	3461	1153
ENST00000515765	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	3893	2301	0	3461	1153
ENST00000515765	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	3889	2301	0	3461	1153
ENST00000515765	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	3883	2301	0	3461	1153
ENST00000515765	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3462	2301	0	3461	1153
ENST00000507336	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	3894	2301	0	3461	1153
ENST00000507336	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	3893	2301	0	3461	1153
ENST00000507336	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	3889	2301	0	3461	1153
ENST00000507336	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	3883	2301	0	3461	1153
ENST00000507336	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3462	2301	0	3461	1153
ENST00000514079	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	3894	2301	0	3461	1153
ENST00000514079	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	3893	2301	0	3461	1153
ENST00000514079	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	3889	2301	0	3461	1153
ENST00000514079	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	3883	2301	0	3461	1153
ENST00000514079	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3462	2301	0	3461	1153
ENST00000507896	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	3894	2301	0	3461	1153
ENST00000507896	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	3893	2301	0	3461	1153
ENST00000507896	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	3889	2301	0	3461	1153
ENST00000507896	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	3883	2301	0	3461	1153
ENST00000507896	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3462	2301	0	3461	1153
ENST00000512389	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	3894	2301	0	3461	1153
ENST00000512389	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	3893	2301	0	3461	1153
ENST00000512389	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	3889	2301	0	3461	1153
ENST00000512389	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	3883	2301	0	3461	1153
ENST00000512389	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3462	2301	0	3461	1153
ENST00000513689	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	3894	2301	0	3461	1153
ENST00000513689	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	3893	2301	0	3461	1153
ENST00000513689	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	3889	2301	0	3461	1153
ENST00000513689	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	3883	2301	0	3461	1153
ENST00000513689	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3462	2301	0	3461	1153
ENST00000513964	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	3894	2301	0	3461	1153
ENST00000513964	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	3893	2301	0	3461	1153
ENST00000513964	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	3889	2301	0	3461	1153
ENST00000513964	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	3883	2301	0	3461	1153
ENST00000513964	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3462	2301	0	3461	1153
ENST00000505165	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	3894	2301	0	3461	1153
ENST00000505165	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	3893	2301	0	3461	1153
ENST00000505165	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	3889	2301	0	3461	1153
ENST00000505165	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	3883	2301	0	3461	1153
ENST00000505165	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3462	2301	0	3461	1153
ENST00000507609	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	3894	2301	0	3461	1153
ENST00000507609	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	3893	2301	0	3461	1153
ENST00000507609	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	3889	2301	0	3461	1153
ENST00000507609	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	3883	2301	0	3461	1153
ENST00000507609	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3462	2301	0	3461	1153
ENST00000514717	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	3894	2301	0	3461	1153
ENST00000514717	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	3893	2301	0	3461	1153
ENST00000514717	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	3889	2301	0	3461	1153
ENST00000514717	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	3883	2301	0	3461	1153
ENST00000514717	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3462	2301	0	3461	1153
ENST00000510366	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	3894	2301	0	3461	1153
ENST00000510366	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	3893	2301	0	3461	1153
ENST00000510366	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	3889	2301	0	3461	1153
ENST00000510366	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	3883	2301	0	3461	1153
ENST00000510366	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3462	2301	0	3461	1153
ENST00000429973	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	3894	2301	0	3461	1153
ENST00000429973	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	3893	2301	0	3461	1153
ENST00000429973	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	3889	2301	0	3461	1153
ENST00000429973	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	3883	2301	0	3461	1153
ENST00000429973	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3462	2301	0	3461	1153
ENST00000359106	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	3894	2301	0	3461	1153
ENST00000359106	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	3893	2301	0	3461	1153
ENST00000359106	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	3889	2301	0	3461	1153
ENST00000359106	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	3883	2301	0	3461	1153
ENST00000359106	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3462	2301	0	3461	1153
ENST00000358244	CACNA1G	chr17	48655925	+	ENST00000394126	MED24	chr17	38182584	-	3894	2301	0	3461	1153
ENST00000358244	CACNA1G	chr17	48655925	+	ENST00000356271	MED24	chr17	38182584	-	3893	2301	0	3461	1153
ENST00000358244	CACNA1G	chr17	48655925	+	ENST00000394128	MED24	chr17	38182584	-	3889	2301	0	3461	1153
ENST00000358244	CACNA1G	chr17	48655925	+	ENST00000394127	MED24	chr17	38182584	-	3883	2301	0	3461	1153
ENST00000358244	CACNA1G	chr17	48655925	+	ENST00000501516	MED24	chr17	38182584	-	3462	2301	0	3461	1153

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000360761	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005604852	0.99439514
ENST00000360761	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.00559037	0.9944096
ENST00000360761	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005701083	0.99429893
ENST00000360761	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005677561	0.9943224
ENST00000360761	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.008745885	0.99125415
ENST00000354983	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005335097	0.9946649
ENST00000354983	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005321472	0.9946785
ENST00000354983	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005428493	0.9945715
ENST00000354983	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005404444	0.9945956
ENST00000354983	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.008306111	0.9916939
ENST00000352832	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005335097	0.9946649
ENST00000352832	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005321472	0.9946785
ENST00000352832	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005428493	0.9945715
ENST00000352832	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005404444	0.9945956
ENST00000352832	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.008306111	0.9916939
ENST00000442258	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.004425463	0.9955746
ENST00000442258	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.004412526	0.99558747
ENST00000442258	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.004511255	0.9954887
ENST00000442258	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.004491506	0.99550855
ENST00000442258	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.007160883	0.99283916
ENST00000416767	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003514708	0.99648523
ENST00000416767	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003503547	0.9964965
ENST00000416767	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.00358755	0.99641246
ENST00000416767	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003572456	0.9964276
ENST00000416767	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005830179	0.99416983
ENST00000502264	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003374944	0.99662507
ENST00000502264	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003364132	0.99663585
ENST00000502264	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003445462	0.9965545
ENST00000502264	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003430676	0.9965693
ENST00000502264	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005610664	0.99438936
ENST00000515411	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003374944	0.99662507
ENST00000515411	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003364132	0.99663585
ENST00000515411	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003445462	0.9965545
ENST00000515411	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003430676	0.9965693
ENST00000515411	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005610664	0.99438936
ENST00000510115	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003374944	0.99662507
ENST00000510115	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003364132	0.99663585
ENST00000510115	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003445462	0.9965545
ENST00000510115	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003430676	0.9965693
ENST00000510115	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005610664	0.99438936
ENST00000503485	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003374944	0.99662507
ENST00000503485	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003364132	0.99663585
ENST00000503485	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003445462	0.9965545
ENST00000503485	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003430676	0.9965693
ENST00000503485	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005610664	0.99438936
ENST00000515165	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003374944	0.99662507
ENST00000515165	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003364132	0.99663585
ENST00000515165	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003445462	0.9965545
ENST00000515165	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003430676	0.9965693
ENST00000515165	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005610664	0.99438936
ENST00000507510	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003374944	0.99662507
ENST00000507510	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003364132	0.99663585
ENST00000507510	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003445462	0.9965545
ENST00000507510	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003430676	0.9965693
ENST00000507510	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005610664	0.99438936
ENST00000514181	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003374944	0.99662507
ENST00000514181	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003364132	0.99663585
ENST00000514181	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003445462	0.9965545
ENST00000514181	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003430676	0.9965693
ENST00000514181	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005610664	0.99438936
ENST00000515765	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003374944	0.99662507
ENST00000515765	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003364132	0.99663585
ENST00000515765	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003445462	0.9965545
ENST00000515765	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003430676	0.9965693
ENST00000515765	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005610664	0.99438936
ENST00000507336	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003374944	0.99662507
ENST00000507336	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003364132	0.99663585
ENST00000507336	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003445462	0.9965545
ENST00000507336	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003430676	0.9965693
ENST00000507336	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005610664	0.99438936
ENST00000514079	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003374944	0.99662507
ENST00000514079	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003364132	0.99663585
ENST00000514079	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003445462	0.9965545
ENST00000514079	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003430676	0.9965693
ENST00000514079	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005610664	0.99438936
ENST00000507896	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003374944	0.99662507
ENST00000507896	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003364132	0.99663585
ENST00000507896	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003445462	0.9965545
ENST00000507896	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003430676	0.9965693
ENST00000507896	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005610664	0.99438936
ENST00000512389	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003374944	0.99662507
ENST00000512389	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003364132	0.99663585
ENST00000512389	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003445462	0.9965545
ENST00000512389	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003430676	0.9965693
ENST00000512389	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005610664	0.99438936
ENST00000513689	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003374944	0.99662507
ENST00000513689	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003364132	0.99663585
ENST00000513689	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003445462	0.9965545
ENST00000513689	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003430676	0.9965693
ENST00000513689	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005610664	0.99438936
ENST00000513964	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003374944	0.99662507
ENST00000513964	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003364132	0.99663585
ENST00000513964	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003445462	0.9965545
ENST00000513964	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003430676	0.9965693
ENST00000513964	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005610664	0.99438936
ENST00000505165	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003374944	0.99662507
ENST00000505165	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003364132	0.99663585
ENST00000505165	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003445462	0.9965545
ENST00000505165	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003430676	0.9965693
ENST00000505165	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005610664	0.99438936
ENST00000507609	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003374944	0.99662507
ENST00000507609	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003364132	0.99663585
ENST00000507609	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003445462	0.9965545
ENST00000507609	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003430676	0.9965693
ENST00000507609	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005610664	0.99438936
ENST00000514717	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003374944	0.99662507
ENST00000514717	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003364132	0.99663585
ENST00000514717	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003445462	0.9965545
ENST00000514717	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003430676	0.9965693
ENST00000514717	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005610664	0.99438936
ENST00000510366	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003374944	0.99662507
ENST00000510366	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003364132	0.99663585
ENST00000510366	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003445462	0.9965545
ENST00000510366	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003430676	0.9965693
ENST00000510366	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005610664	0.99438936
ENST00000429973	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003374944	0.99662507
ENST00000429973	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003364132	0.99663585
ENST00000429973	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003445462	0.9965545
ENST00000429973	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003430676	0.9965693
ENST00000429973	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005610664	0.99438936
ENST00000359106	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003374944	0.99662507
ENST00000359106	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003364132	0.99663585
ENST00000359106	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003445462	0.9965545
ENST00000359106	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003430676	0.9965693
ENST00000359106	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005610664	0.99438936
ENST00000358244	ENST00000394126	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003374944	0.99662507
ENST00000358244	ENST00000356271	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003364132	0.99663585
ENST00000358244	ENST00000394128	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003445462	0.9965545
ENST00000358244	ENST00000394127	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.003430676	0.9965693
ENST00000358244	ENST00000501516	CACNA1G	chr17	48655925	+	MED24	chr17	38182584	-	0.005610664	0.99438936

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

Top

Fusion Protein Breakpoint Sequences for CACNA1G-MED24

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
CACNA1G	chr17	48655925	MED24	chr17	38182584	2301	767	VNTLSMGIEYHEQKITDNIKGKVCSL
CACNA1G	chr17	48655925	MED24	chr17	38182584	2329	767	VNTLSMGIEYHEQKITDNIKGKVCSL
CACNA1G	chr17	48655925	MED24	chr17	38182584	2476	792	VNTLSMGIEYHEQKITDNIKGKVCSL
CACNA1G	chr17	48655925	MED24	chr17	38182584	2673	792	VNTLSMGIEYHEQKITDNIKGKVCSL
CACNA1G	chr17	48655925	MED24	chr17	38182584	2693	792	VNTLSMGIEYHEQKITDNIKGKVCSL

Top

Potential FusionNeoAntigen Information of CACNA1G-MED24 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

CACNA1G-MED24_48655925_38182584.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
CACNA1G-MED24	chr17	48655925	chr17	38182584	2673	HLA-B52:01	IEYHEQKI	0.9836	0.721	7	15
CACNA1G-MED24	chr17	48655925	chr17	38182584	2673	HLA-B13:01	HEQKITDNI	0.9829	0.7739	10	19
CACNA1G-MED24	chr17	48655925	chr17	38182584	2673	HLA-B41:01	HEQKITDNI	0.6183	0.7126	10	19
CACNA1G-MED24	chr17	48655925	chr17	38182584	2673	HLA-B39:13	HEQKITDNI	0.5383	0.8407	10	19
CACNA1G-MED24	chr17	48655925	chr17	38182584	2673	HLA-B50:01	IEYHEQKIT	0.2883	0.651	7	16
CACNA1G-MED24	chr17	48655925	chr17	38182584	2673	HLA-B38:01	YHEQKITDNI	0.9838	0.8521	9	19
CACNA1G-MED24	chr17	48655925	chr17	38182584	2673	HLA-B51:07	IEYHEQKI	0.9874	0.5656	7	15
CACNA1G-MED24	chr17	48655925	chr17	38182584	2673	HLA-B39:08	HEQKITDNI	0.5214	0.6811	10	19
CACNA1G-MED24	chr17	48655925	chr17	38182584	2673	HLA-B50:04	IEYHEQKIT	0.2883	0.651	7	16
CACNA1G-MED24	chr17	48655925	chr17	38182584	2673	HLA-B50:05	IEYHEQKIT	0.2883	0.651	7	16
CACNA1G-MED24	chr17	48655925	chr17	38182584	2673	HLA-B38:05	YHEQKITDNI	0.9838	0.8521	9	19

Top

Potential FusionNeoAntigen Information of CACNA1G-MED24 in HLA II

CACNA1G-MED24_48655925_38182584.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
CACNA1G-MED24	chr17	48655925	chr17	38182584	2673	DRB1-1438	HEQKITDNIKGKVCS	10	25

Top

Fusion breakpoint peptide structures of CACNA1G-MED24

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
2864	GIEYHEQKITDNIK	CACNA1G	MED24	chr17	48655925	chr17	38182584	2673

Top

Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of CACNA1G-MED24

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	2864	GIEYHEQKITDNIK	-7.9962	-8.1096
HLA-B14:02	3BVN	2864	GIEYHEQKITDNIK	-5.70842	-6.74372
HLA-B52:01	3W39	2864	GIEYHEQKITDNIK	-6.83737	-6.95077
HLA-B52:01	3W39	2864	GIEYHEQKITDNIK	-4.4836	-5.5189
HLA-A11:01	4UQ2	2864	GIEYHEQKITDNIK	-10.0067	-10.1201
HLA-A11:01	4UQ2	2864	GIEYHEQKITDNIK	-9.03915	-10.0745
HLA-A24:02	5HGA	2864	GIEYHEQKITDNIK	-6.56204	-6.67544
HLA-A24:02	5HGA	2864	GIEYHEQKITDNIK	-5.42271	-6.45801
HLA-B44:05	3DX8	2864	GIEYHEQKITDNIK	-7.85648	-8.89178
HLA-B44:05	3DX8	2864	GIEYHEQKITDNIK	-5.3978	-5.5112
HLA-A02:01	6TDR	2864	GIEYHEQKITDNIK	-3.37154	-4.40684

Top

Vaccine Design for the FusionNeoAntigens of CACNA1G-MED24

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
CACNA1G-MED24	chr17	48655925	chr17	38182584	10	19	HEQKITDNI	CACGAGCAGAAAATCACTGATAACATC
CACNA1G-MED24	chr17	48655925	chr17	38182584	7	15	IEYHEQKI	ATCGAATACCACGAGCAGAAAATC
CACNA1G-MED24	chr17	48655925	chr17	38182584	7	16	IEYHEQKIT	ATCGAATACCACGAGCAGAAAATCACT
CACNA1G-MED24	chr17	48655925	chr17	38182584	9	19	YHEQKITDNI	TACCACGAGCAGAAAATCACTGATAACATC

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
CACNA1G-MED24	chr17	48655925	chr17	38182584	10	25	HEQKITDNIKGKVCS	CACGAGCAGAAAATCACTGATAACATCAAAGGGAAGGTATGCAGT

Top

Information of the samples that have these potential fusion neoantigens of CACNA1G-MED24

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
BRCA	CACNA1G-MED24	chr17	48655925	ENST00000352832	chr17	38182584	ENST00000356271	TCGA-AR-A24U-01A

Top

Potential target of CAR-T therapy development for CACNA1G-MED24

Predicted 3D structure. We used RoseTTAFold.

75_CACNA1G-MED24_t000_.e2e.pdb

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000352832

120_141

767

2251.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000352832

151_170

767

2251.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000352832

176_193

767

2251.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000352832

214_234

767

2251.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000352832

371_395

767

2251.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000352832

744_764

767

2251.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000352832

81_101

767

2251.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000354983

120_141

767

2344.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000354983

151_170

767

2344.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000354983

176_193

767

2344.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000354983

214_234

767

2344.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000354983

371_395

767

2344.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000354983

744_764

767

2344.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000354983

81_101

767

2344.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000358244

120_141

767

2172.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000358244

151_170

767

2172.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000358244

176_193

767

2172.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000358244

214_234

767

2172.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000358244

371_395

767

2172.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000358244

744_764

767

2172.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000358244

81_101

767

2172.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000359106

120_141

767

2378.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000359106

151_170

767

2378.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000359106

176_193

767

2378.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000359106

214_234

767

2378.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000359106

371_395

767

2378.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000359106

744_764

767

2378.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000359106

81_101

767

2378.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000360761

120_141

767

2262.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000360761

151_170

767

2262.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000360761

176_193

767

2262.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000360761

214_234

767

2262.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000360761

371_395

767

2262.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000360761

744_764

767

2262.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000360761

81_101

767

2262.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000429973

120_141

767

2267.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000429973

151_170

767

2267.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000429973

176_193

767

2267.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000429973

214_234

767

2267.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000429973

371_395

767

2267.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000429973

744_764

767

2267.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000429973

81_101

767

2267.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000442258

120_141

767

2244.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000442258

151_170

767

2244.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000442258

176_193

767

2244.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000442258

214_234

767

2244.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000442258

371_395

767

2244.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000442258

744_764

767

2244.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000442258

81_101

767

2244.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000502264

120_141

767

2307.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000502264

151_170

767

2307.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000502264

176_193

767

2307.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000502264

214_234

767

2307.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000502264

371_395

767

2307.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000502264

744_764

767

2307.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000502264

81_101

767

2307.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000503485

120_141

767

2251.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000503485

151_170

767

2251.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000503485

176_193

767

2251.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000503485

214_234

767

2251.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000503485

371_395

767

2251.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000503485

744_764

767

2251.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000503485

81_101

767

2251.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000505165

120_141

767

2206.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000505165

151_170

767

2206.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000505165

176_193

767

2206.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000505165

214_234

767

2206.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000505165

371_395

767

2206.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000505165

744_764

767

2206.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000505165

81_101

767

2206.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507336

120_141

767

2367.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507336

151_170

767

2367.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507336

176_193

767

2367.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507336

214_234

767

2367.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507336

371_395

767

2367.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507336

744_764

767

2367.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507336

81_101

767

2367.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507510

120_141

767

2333.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507510

151_170

767

2333.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507510

176_193

767

2333.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507510

214_234

767

2333.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507510

371_395

767

2333.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507510

744_764

767

2333.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507510

81_101

767

2333.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507609

120_141

767

2278.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507609

151_170

767

2278.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507609

176_193

767

2278.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507609

214_234

767

2278.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507609

371_395

767

2278.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507609

744_764

767

2278.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507609

81_101

767

2278.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507896

120_141

767

2195.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507896

151_170

767

2195.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507896

176_193

767

2195.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507896

214_234

767

2195.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507896

371_395

767

2195.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507896

744_764

767

2195.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000507896

81_101

767

2195.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000510115

120_141

767

2299.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000510115

151_170

767

2299.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000510115

176_193

767

2299.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000510115

214_234

767

2299.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000510115

371_395

767

2299.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000510115

744_764

767

2299.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000510115

81_101

767

2299.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000510366

120_141

767

2233.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000510366

151_170

767

2233.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000510366

176_193

767

2233.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000510366

214_234

767

2233.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000510366

371_395

767

2233.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000510366

744_764

767

2233.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000510366

81_101

767

2233.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000512389

120_141

767

2274.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000512389

151_170

767

2274.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000512389

176_193

767

2274.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000512389

214_234

767

2274.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000512389

371_395

767

2274.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000512389

744_764

767

2274.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000512389

81_101

767

2274.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000513689

120_141

767

2288.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000513689

151_170

767

2288.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000513689

176_193

767

2288.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000513689

214_234

767

2288.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000513689

371_395

767

2288.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000513689

744_764

767

2288.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000513689

81_101

767

2288.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000513964

120_141

767

2240.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000513964

151_170

767

2240.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000513964

176_193

767

2240.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000513964

214_234

767

2240.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000513964

371_395

767

2240.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000513964

744_764

767

2240.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000513964

81_101

767

2240.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000514079

120_141

767

2292.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000514079

151_170

767

2292.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000514079

176_193

767

2292.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000514079

214_234

767

2292.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000514079

371_395

767

2292.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000514079

744_764

767

2292.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000514079

81_101

767

2292.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000514181

120_141

767

2260.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000514181

151_170

767

2260.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000514181

176_193

767

2260.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000514181

214_234

767

2260.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000514181

371_395

767

2260.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000514181

744_764

767

2260.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000514181

81_101

767

2260.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000514717

120_141

767

2228.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000514717

151_170

767

2228.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000514717

176_193

767

2228.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000514717

214_234

767

2228.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000514717

371_395

767

2228.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000514717

744_764

767

2228.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000514717

81_101

767

2228.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000515165

120_141

767

2285.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000515165

151_170

767

2285.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000515165

176_193

767

2285.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000515165

214_234

767

2285.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000515165

371_395

767

2285.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000515165

744_764

767

2285.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000515165

81_101

767

2285.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000515411

120_141

767

2315.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000515411

151_170

767

2315.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000515411

176_193

767

2315.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000515411

214_234

767

2315.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000515411

371_395

767

2315.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000515411

744_764

767

2315.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000515411

81_101

767

2315.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000515765

120_141

767

2322.0

Transmembrane

Helical%3B Name%3DS2 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000515765

151_170

767

2322.0

Transmembrane

Helical%3B Name%3DS3 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000515765

176_193

767

2322.0

Transmembrane

Helical%3B Name%3DS4 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000515765

214_234

767

2322.0

Transmembrane

Helical%3B Name%3DS5 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000515765

371_395

767

2322.0

Transmembrane

Helical%3B Name%3DS6 of repeat I

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000515765

744_764

767

2322.0

Transmembrane

Helical%3B Name%3DS1 of repeat II

Hgene

CACNA1G

chr17:48655925

chr17:38182584

ENST00000515765

81_101

767

2322.0

Transmembrane

Helical%3B Name%3DS1 of repeat I

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene	Hchr	Hbp	Henst	Tgene	Tchr	Tbp	Tenst	DeepLoc result
CACNA1G	chr17	48655925	ENST00000352832	MED24	chr17	38182584	ENST00000356271
CACNA1G	chr17	48655925	ENST00000358244	MED24	chr17	38182584	ENST00000356271
CACNA1G	chr17	48655925	ENST00000360761	MED24	chr17	38182584	ENST00000501516
CACNA1G	chr17	48655925	ENST00000416767	MED24	chr17	38182584	ENST00000501516

Top

Related Drugs to CACNA1G-MED24

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to CACNA1G-MED24

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)