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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:CACNA2D3-TEX264

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CACNA2D3-TEX264
FusionPDB ID: 12374
FusionGDB2.0 ID: 12374
HgeneTgene
Gene symbol

CACNA2D3

TEX264

Gene ID

55799

51368

Gene namecalcium voltage-gated channel auxiliary subunit alpha2delta 3testis expressed 264, ER-phagy receptor
SynonymsHSA272268ZSIG11
Cytomap

3p21.1-p14.3

3p21.2

Type of geneprotein-codingprotein-coding
Descriptionvoltage-dependent calcium channel subunit alpha-2/delta-3calcium channel alpha2-delta3 subunitcalcium channel, voltage-dependent, alpha 2/delta 3 subunitcalcium channel, voltage-dependent, alpha 2/delta subunit 3voltage-gated calcium channel subunit atestis-expressed protein 264testis expressed 264testis expressed gene 264testis-expressed sequence 264 protein
Modification date2020031320200313
UniProtAcc

Q8IZS8

Main function of 5'-partner protein: FUNCTION: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). {ECO:0000250}.		.
Ensembl transtripts involved in fusion geneENST idsENST00000288197, ENST00000415676, 
ENST00000474759, ENST00000490478, 
ENST00000478261, 		ENST00000463857, 
ENST00000341333, ENST00000395057, 
ENST00000415259, ENST00000416589, 
ENST00000457573, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 12 X 6=10085 X 7 X 5=175
# samples 156
** MAII scorelog2(15/1008*10)=-2.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/175*10)=-1.54432051622381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: CACNA2D3 [Title/Abstract] AND TEX264 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: CACNA2D3 [Title/Abstract] AND TEX264 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CACNA2D3(54798378)-TEX264(51718428), # samples:1
Anticipated loss of major functional domain due to fusion event.CACNA2D3-TEX264 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CACNA2D3-TEX264 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CACNA2D3-TEX264 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CACNA2D3-TEX264 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:54798378/chr3:51718428)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across CACNA2D3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TEX264 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000415676CACNA2D3chr354798378+ENST00000457573TEX264chr351718428+248814981182181687
ENST00000415676CACNA2D3chr354798378+ENST00000341333TEX264chr351718428+248914981182181687
ENST00000415676CACNA2D3chr354798378+ENST00000415259TEX264chr351718428+244914981182181687
ENST00000415676CACNA2D3chr354798378+ENST00000395057TEX264chr351718428+248714981182181687
ENST00000415676CACNA2D3chr354798378+ENST00000416589TEX264chr351718428+248314981182181687
ENST00000288197CACNA2D3chr354798378+ENST00000457573TEX264chr351718428+24181428482111687
ENST00000288197CACNA2D3chr354798378+ENST00000341333TEX264chr351718428+24191428482111687
ENST00000288197CACNA2D3chr354798378+ENST00000415259TEX264chr351718428+23791428482111687
ENST00000288197CACNA2D3chr354798378+ENST00000395057TEX264chr351718428+24171428482111687
ENST00000288197CACNA2D3chr354798378+ENST00000416589TEX264chr351718428+24131428482111687
ENST00000474759CACNA2D3chr354798378+ENST00000457573TEX264chr351718428+24181428482111687
ENST00000474759CACNA2D3chr354798378+ENST00000341333TEX264chr351718428+24191428482111687
ENST00000474759CACNA2D3chr354798378+ENST00000415259TEX264chr351718428+23791428482111687
ENST00000474759CACNA2D3chr354798378+ENST00000395057TEX264chr351718428+24171428482111687
ENST00000474759CACNA2D3chr354798378+ENST00000416589TEX264chr351718428+24131428482111687
ENST00000490478CACNA2D3chr354798378+ENST00000457573TEX264chr351718428+230013101251993622
ENST00000490478CACNA2D3chr354798378+ENST00000341333TEX264chr351718428+230113101251993622
ENST00000490478CACNA2D3chr354798378+ENST00000415259TEX264chr351718428+226113101251993622
ENST00000490478CACNA2D3chr354798378+ENST00000395057TEX264chr351718428+229913101251993622
ENST00000490478CACNA2D3chr354798378+ENST00000416589TEX264chr351718428+229513101251993622

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000415676ENST00000457573CACNA2D3chr354798378+TEX264chr351718428+0.0051662160.9948338
ENST00000415676ENST00000341333CACNA2D3chr354798378+TEX264chr351718428+0.0051873310.9948127
ENST00000415676ENST00000415259CACNA2D3chr354798378+TEX264chr351718428+0.0057610660.994239
ENST00000415676ENST00000395057CACNA2D3chr354798378+TEX264chr351718428+0.0052011040.9947989
ENST00000415676ENST00000416589CACNA2D3chr354798378+TEX264chr351718428+0.0052445720.9947554
ENST00000288197ENST00000457573CACNA2D3chr354798378+TEX264chr351718428+0.0049858340.99501413
ENST00000288197ENST00000341333CACNA2D3chr354798378+TEX264chr351718428+0.005017390.9949826
ENST00000288197ENST00000415259CACNA2D3chr354798378+TEX264chr351718428+0.0053314290.99466854
ENST00000288197ENST00000395057CACNA2D3chr354798378+TEX264chr351718428+0.0050195710.9949804
ENST00000288197ENST00000416589CACNA2D3chr354798378+TEX264chr351718428+0.0049926580.9950073
ENST00000474759ENST00000457573CACNA2D3chr354798378+TEX264chr351718428+0.0049858340.99501413
ENST00000474759ENST00000341333CACNA2D3chr354798378+TEX264chr351718428+0.005017390.9949826
ENST00000474759ENST00000415259CACNA2D3chr354798378+TEX264chr351718428+0.0053314290.99466854
ENST00000474759ENST00000395057CACNA2D3chr354798378+TEX264chr351718428+0.0050195710.9949804
ENST00000474759ENST00000416589CACNA2D3chr354798378+TEX264chr351718428+0.0049926580.9950073
ENST00000490478ENST00000457573CACNA2D3chr354798378+TEX264chr351718428+0.0045703510.99542964
ENST00000490478ENST00000341333CACNA2D3chr354798378+TEX264chr351718428+0.0045878850.9954122
ENST00000490478ENST00000415259CACNA2D3chr354798378+TEX264chr351718428+0.0048720130.9951279
ENST00000490478ENST00000395057CACNA2D3chr354798378+TEX264chr351718428+0.0046018680.9953981
ENST00000490478ENST00000416589CACNA2D3chr354798378+TEX264chr351718428+0.0045797990.9954202

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for CACNA2D3-TEX264

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
CACNA2D3chr354798378TEX264chr3517184281310395HDVVWTEAYIDSTVPPDKCRCAVGSI
CACNA2D3chr354798378TEX264chr3517184281428460HDVVWTEAYIDSTVPPDKCRCAVGSI
CACNA2D3chr354798378TEX264chr3517184281498460HDVVWTEAYIDSTVPPDKCRCAVGSI

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Potential FusionNeoAntigen Information of CACNA2D3-TEX264 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
CACNA2D3-TEX264_54798378_51718428.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
CACNA2D3-TEX264chr354798378chr3517184281428HLA-B45:01TEAYIDSTV0.99610.7415514
CACNA2D3-TEX264chr354798378chr3517184281428HLA-B50:01TEAYIDSTV0.48940.6017514
CACNA2D3-TEX264chr354798378chr3517184281428HLA-B41:01TEAYIDSTV0.4850.8844514
CACNA2D3-TEX264chr354798378chr3517184281428HLA-B40:04TEAYIDSTV0.98850.7389514
CACNA2D3-TEX264chr354798378chr3517184281428HLA-B41:03TEAYIDSTV0.59280.5655514
CACNA2D3-TEX264chr354798378chr3517184281428HLA-B50:04TEAYIDSTV0.48940.6017514
CACNA2D3-TEX264chr354798378chr3517184281428HLA-B50:05TEAYIDSTV0.48940.6017514

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Potential FusionNeoAntigen Information of CACNA2D3-TEX264 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
CACNA2D3-TEX264_54798378_51718428.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0405TEAYIDSTVPPDKCR520
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0405VWTEAYIDSTVPPDK318
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0405WTEAYIDSTVPPDKC419
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0409TEAYIDSTVPPDKCR520
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0409VWTEAYIDSTVPPDK318
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0409WTEAYIDSTVPPDKC419
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0409EAYIDSTVPPDKCRC621
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0417VWTEAYIDSTVPPDK318
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0417TEAYIDSTVPPDKCR520
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0417WTEAYIDSTVPPDKC419
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0417EAYIDSTVPPDKCRC621
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0424TEAYIDSTVPPDKCR520
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0424VWTEAYIDSTVPPDK318
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0429TEAYIDSTVPPDKCR520
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0429VWTEAYIDSTVPPDK318
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0429WTEAYIDSTVPPDKC419
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0430TEAYIDSTVPPDKCR520
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0430VWTEAYIDSTVPPDK318
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0430WTEAYIDSTVPPDKC419
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0445TEAYIDSTVPPDKCR520
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0445VWTEAYIDSTVPPDK318
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0445WTEAYIDSTVPPDKC419
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0448TEAYIDSTVPPDKCR520
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0448VWTEAYIDSTVPPDK318
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0448WTEAYIDSTVPPDKC419
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0457TEAYIDSTVPPDKCR520
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0457VWTEAYIDSTVPPDK318
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0457WTEAYIDSTVPPDKC419
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0462TEAYIDSTVPPDKCR520
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0462VWTEAYIDSTVPPDK318
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0462WTEAYIDSTVPPDKC419
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0469VWTEAYIDSTVPPDK318
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0469TEAYIDSTVPPDKCR520
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0469WTEAYIDSTVPPDKC419
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0477TEAYIDSTVPPDKCR520
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0477VWTEAYIDSTVPPDK318
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0477WTEAYIDSTVPPDKC419
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0480TEAYIDSTVPPDKCR520
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0480VWTEAYIDSTVPPDK318
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0480WTEAYIDSTVPPDKC419
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0483TEAYIDSTVPPDKCR520
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0483VWTEAYIDSTVPPDK318
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0483WTEAYIDSTVPPDKC419
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0484TEAYIDSTVPPDKCR520
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0484VWTEAYIDSTVPPDK318
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0484WTEAYIDSTVPPDKC419
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0486TEAYIDSTVPPDKCR520
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0487TEAYIDSTVPPDKCR520
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0487VWTEAYIDSTVPPDK318
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0487WTEAYIDSTVPPDKC419
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0489TEAYIDSTVPPDKCR520
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0489VWTEAYIDSTVPPDK318
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0489WTEAYIDSTVPPDKC419
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0908VWTEAYIDSTVPPDK318
CACNA2D3-TEX264chr354798378chr3517184281428DRB1-0908TEAYIDSTVPPDKCR520

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Fusion breakpoint peptide structures of CACNA2D3-TEX264

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
1559EAYIDSTVPPDKCRCACNA2D3TEX264chr354798378chr3517184281428

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of CACNA2D3-TEX264

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN1559EAYIDSTVPPDKCR-7.9962-8.1096
HLA-B14:023BVN1559EAYIDSTVPPDKCR-5.70842-6.74372
HLA-B52:013W391559EAYIDSTVPPDKCR-6.83737-6.95077
HLA-B52:013W391559EAYIDSTVPPDKCR-4.4836-5.5189
HLA-A11:014UQ21559EAYIDSTVPPDKCR-10.0067-10.1201
HLA-A11:014UQ21559EAYIDSTVPPDKCR-9.03915-10.0745
HLA-A24:025HGA1559EAYIDSTVPPDKCR-6.56204-6.67544
HLA-A24:025HGA1559EAYIDSTVPPDKCR-5.42271-6.45801
HLA-B44:053DX81559EAYIDSTVPPDKCR-7.85648-8.89178
HLA-B44:053DX81559EAYIDSTVPPDKCR-5.3978-5.5112
HLA-A02:016TDR1559EAYIDSTVPPDKCR-3.37154-4.40684

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Vaccine Design for the FusionNeoAntigens of CACNA2D3-TEX264

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
CACNA2D3-TEX264chr354798378chr351718428514TEAYIDSTVACCGAAGCTTACATTGACAGCACTGTG

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
CACNA2D3-TEX264chr354798378chr351718428318VWTEAYIDSTVPPDKGTGTGGACCGAAGCTTACATTGACAGCACTGTGCCCCCTGATAAG
CACNA2D3-TEX264chr354798378chr351718428419WTEAYIDSTVPPDKCTGGACCGAAGCTTACATTGACAGCACTGTGCCCCCTGATAAGTGC
CACNA2D3-TEX264chr354798378chr351718428520TEAYIDSTVPPDKCRACCGAAGCTTACATTGACAGCACTGTGCCCCCTGATAAGTGCCGA
CACNA2D3-TEX264chr354798378chr351718428621EAYIDSTVPPDKCRCGAAGCTTACATTGACAGCACTGTGCCCCCTGATAAGTGCCGATGT

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Information of the samples that have these potential fusion neoantigens of CACNA2D3-TEX264

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
OVCACNA2D3-TEX264chr354798378ENST00000288197chr351718428ENST00000341333TCGA-20-0987

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Potential target of CAR-T therapy development for CACNA2D3-TEX264

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to CACNA2D3-TEX264

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CACNA2D3-TEX264

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource