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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:CALD1-EXOC4

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CALD1-EXOC4
FusionPDB ID: 12514
FusionGDB2.0 ID: 12514
HgeneTgene
Gene symbol

CALD1

EXOC4

Gene ID

800

60412

Gene namecaldesmon 1exocyst complex component 4
SynonymsCDM|H-CAD|HCAD|L-CAD|LCAD|NAG22SEC8|SEC8L1|Sec8p
Cytomap

7q33

7q33

Type of geneprotein-codingprotein-coding
Descriptioncaldesmontestis secretory sperm-binding protein Li 227nexocyst complex component 4SEC8-like 1exocyst complex component Sec8
Modification date2020031320200320
UniProtAcc

Q05682

Main function of 5'-partner protein: FUNCTION: Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}.

Q96A65

Main function of 5'-partner protein: FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250}.
Ensembl transtripts involved in fusion geneENST idsENST00000361388, ENST00000361675, 
ENST00000361901, ENST00000417172, 
ENST00000422748, ENST00000393118, 
ENST00000424922, ENST00000466704, 
ENST00000495522, ENST00000543443, 
ENST00000460346, ENST00000393161, 
ENST00000541309, ENST00000545148, 
ENST00000253861, ENST00000539845, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score20 X 22 X 11=484035 X 25 X 10=8750
# samples 2939
** MAII scorelog2(29/4840*10)=-4.06088224214702
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(39/8750*10)=-4.48773698785744
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: CALD1 [Title/Abstract] AND EXOC4 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: CALD1 [Title/Abstract] AND EXOC4 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CALD1(134552555)-EXOC4(133502077), # samples:1
CALD1(134552555)-EXOC4(133502078), # samples:1
CALD1(134464500)-EXOC4(133749044), # samples:1
Anticipated loss of major functional domain due to fusion event.CALD1-EXOC4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CALD1-EXOC4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:134552555/chr7:133502077)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across CALD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EXOC4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000417172CALD1chr7134552555+ENST00000253861EXOC4chr7133502077+29543122411722493
ENST00000417172CALD1chr7134552555+ENST00000539845EXOC4chr7133502077+17823122411722493
ENST00000361388CALD1chr7134552555+ENST00000253861EXOC4chr7133502077+31795374661947493
ENST00000361388CALD1chr7134552555+ENST00000539845EXOC4chr7133502077+20075374661947493
ENST00000422748CALD1chr7134552555+ENST00000253861EXOC4chr7133502077+31725304591940493
ENST00000422748CALD1chr7134552555+ENST00000539845EXOC4chr7133502077+20005304591940493
ENST00000361675CALD1chr7134552555+ENST00000253861EXOC4chr7133502077+29423002291710493
ENST00000361675CALD1chr7134552555+ENST00000539845EXOC4chr7133502077+17703002291710493
ENST00000361901CALD1chr7134552555+ENST00000253861EXOC4chr7133502077+29142722011682493
ENST00000361901CALD1chr7134552555+ENST00000539845EXOC4chr7133502077+17422722011682493
ENST00000417172CALD1chr7134552555+ENST00000253861EXOC4chr7133502078+29543122411722493
ENST00000417172CALD1chr7134552555+ENST00000539845EXOC4chr7133502078+17823122411722493
ENST00000361388CALD1chr7134552555+ENST00000253861EXOC4chr7133502078+31795374661947493
ENST00000361388CALD1chr7134552555+ENST00000539845EXOC4chr7133502078+20075374661947493
ENST00000422748CALD1chr7134552555+ENST00000253861EXOC4chr7133502078+31725304591940493
ENST00000422748CALD1chr7134552555+ENST00000539845EXOC4chr7133502078+20005304591940493
ENST00000361675CALD1chr7134552555+ENST00000253861EXOC4chr7133502078+29423002291710493
ENST00000361675CALD1chr7134552555+ENST00000539845EXOC4chr7133502078+17703002291710493
ENST00000361901CALD1chr7134552555+ENST00000253861EXOC4chr7133502078+29142722011682493
ENST00000361901CALD1chr7134552555+ENST00000539845EXOC4chr7133502078+17422722011682493

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000417172ENST00000253861CALD1chr7134552555+EXOC4chr7133502077+0.0007691160.99923086
ENST00000417172ENST00000539845CALD1chr7134552555+EXOC4chr7133502077+0.0018288610.9981711
ENST00000361388ENST00000253861CALD1chr7134552555+EXOC4chr7133502077+0.0006566890.99934334
ENST00000361388ENST00000539845CALD1chr7134552555+EXOC4chr7133502077+0.0011787670.9988212
ENST00000422748ENST00000253861CALD1chr7134552555+EXOC4chr7133502077+0.0006468740.9993531
ENST00000422748ENST00000539845CALD1chr7134552555+EXOC4chr7133502077+0.001136540.99886346
ENST00000361675ENST00000253861CALD1chr7134552555+EXOC4chr7133502077+0.0006921150.9993079
ENST00000361675ENST00000539845CALD1chr7134552555+EXOC4chr7133502077+0.0014009230.9985991
ENST00000361901ENST00000253861CALD1chr7134552555+EXOC4chr7133502077+0.0006596670.99934036
ENST00000361901ENST00000539845CALD1chr7134552555+EXOC4chr7133502077+0.0016607390.9983393
ENST00000417172ENST00000253861CALD1chr7134552555+EXOC4chr7133502078+0.0007691160.99923086
ENST00000417172ENST00000539845CALD1chr7134552555+EXOC4chr7133502078+0.0018288610.9981711
ENST00000361388ENST00000253861CALD1chr7134552555+EXOC4chr7133502078+0.0006566890.99934334
ENST00000361388ENST00000539845CALD1chr7134552555+EXOC4chr7133502078+0.0011787670.9988212
ENST00000422748ENST00000253861CALD1chr7134552555+EXOC4chr7133502078+0.0006468740.9993531
ENST00000422748ENST00000539845CALD1chr7134552555+EXOC4chr7133502078+0.001136540.99886346
ENST00000361675ENST00000253861CALD1chr7134552555+EXOC4chr7133502078+0.0006921150.9993079
ENST00000361675ENST00000539845CALD1chr7134552555+EXOC4chr7133502078+0.0014009230.9985991
ENST00000361901ENST00000253861CALD1chr7134552555+EXOC4chr7133502078+0.0006596670.99934036
ENST00000361901ENST00000539845CALD1chr7134552555+EXOC4chr7133502078+0.0016607390.9983393

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for CALD1-EXOC4

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
CALD1chr7134552555EXOC4chr713350207727223RRQKREEMRLEAERFIQEIEHALGLG
CALD1chr7134552555EXOC4chr713350207730023RRQKREEMRLEAERFIQEIEHALGLG
CALD1chr7134552555EXOC4chr713350207731223RRQKREEMRLEAERFIQEIEHALGLG
CALD1chr7134552555EXOC4chr713350207753023RRQKREEMRLEAERFIQEIEHALGLG
CALD1chr7134552555EXOC4chr713350207753723RRQKREEMRLEAERFIQEIEHALGLG
CALD1chr7134552555EXOC4chr713350207827223RRQKREEMRLEAERFIQEIEHALGLG
CALD1chr7134552555EXOC4chr713350207830023RRQKREEMRLEAERFIQEIEHALGLG
CALD1chr7134552555EXOC4chr713350207831223RRQKREEMRLEAERFIQEIEHALGLG
CALD1chr7134552555EXOC4chr713350207853023RRQKREEMRLEAERFIQEIEHALGLG
CALD1chr7134552555EXOC4chr713350207853723RRQKREEMRLEAERFIQEIEHALGLG

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Potential FusionNeoAntigen Information of CALD1-EXOC4 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
CALD1-EXOC4_134552555_133502077.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
CALD1-EXOC4chr7134552555chr7133502077537HLA-B41:01AERFIQEI0.99420.95391119
CALD1-EXOC4chr7134552555chr7133502077537HLA-B52:01AERFIQEI0.98140.93461119
CALD1-EXOC4chr7134552555chr7133502077537HLA-B15:02EMRLEAERF0.78620.9111615
CALD1-EXOC4chr7134552555chr7133502077537HLA-B44:03EEMRLEAERF0.99920.9546515
CALD1-EXOC4chr7134552555chr7133502077537HLA-B39:24ERFIQEIEHAL0.99990.50071223
CALD1-EXOC4chr7134552555chr7133502077537HLA-B39:01ERFIQEIEHAL0.99990.93161223
CALD1-EXOC4chr7134552555chr7133502077537HLA-B39:06ERFIQEIEHAL0.99980.82721223
CALD1-EXOC4chr7134552555chr7133502077537HLA-B38:02ERFIQEIEHAL0.99970.96051223
CALD1-EXOC4chr7134552555chr7133502077537HLA-B45:01AERFIQEIEHA0.99950.92371122
CALD1-EXOC4chr7134552555chr7133502077537HLA-B14:01ERFIQEIEHAL0.99940.67731223
CALD1-EXOC4chr7134552555chr7133502077537HLA-B14:02ERFIQEIEHAL0.99940.67731223
CALD1-EXOC4chr7134552555chr7133502077537HLA-B50:02AERFIQEIEHA0.9980.59921122
CALD1-EXOC4chr7134552555chr7133502077537HLA-B41:01AERFIQEIEHA0.99460.96961122
CALD1-EXOC4chr7134552555chr7133502077537HLA-B40:06AERFIQEI0.99990.75471119
CALD1-EXOC4chr7134552555chr7133502077537HLA-C07:95MRLEAERFI0.99190.8345716
CALD1-EXOC4chr7134552555chr7133502077537HLA-B51:07EAERFIQEI0.9910.78291019
CALD1-EXOC4chr7134552555chr7133502077537HLA-B73:01ERFIQEIEHA0.99840.61141222
CALD1-EXOC4chr7134552555chr7133502077537HLA-B39:09ERFIQEIEHAL0.99990.65791223
CALD1-EXOC4chr7134552555chr7133502077537HLA-B40:06AERFIQEIEHA0.99990.85381122
CALD1-EXOC4chr7134552555chr7133502077537HLA-B39:12ERFIQEIEHAL0.99980.93621223
CALD1-EXOC4chr7134552555chr7133502077537HLA-B41:03AERFIQEI0.99180.67341119
CALD1-EXOC4chr7134552555chr7133502077537HLA-B27:06MRLEAERFI0.99890.7071716
CALD1-EXOC4chr7134552555chr7133502077537HLA-B27:09MRLEAERFI0.99860.8109716
CALD1-EXOC4chr7134552555chr7133502077537HLA-C07:01MRLEAERFI0.99380.8094716
CALD1-EXOC4chr7134552555chr7133502077537HLA-C06:08MRLEAERFI0.82670.9872716
CALD1-EXOC4chr7134552555chr7133502077537HLA-C07:22MRLEAERFI0.68870.8662716
CALD1-EXOC4chr7134552555chr7133502077537HLA-B15:12EMRLEAERF0.61030.7407615
CALD1-EXOC4chr7134552555chr7133502077537HLA-B15:13EMRLEAERF0.55060.5962615
CALD1-EXOC4chr7134552555chr7133502077537HLA-C06:06MRLEAERFI0.33410.9914716
CALD1-EXOC4chr7134552555chr7133502077537HLA-C06:02MRLEAERFI0.01660.9952716
CALD1-EXOC4chr7134552555chr7133502077537HLA-C06:17MRLEAERFI0.01660.9952716
CALD1-EXOC4chr7134552555chr7133502077537HLA-B44:26EEMRLEAERF0.99920.9546515
CALD1-EXOC4chr7134552555chr7133502077537HLA-B44:07EEMRLEAERF0.99920.9546515
CALD1-EXOC4chr7134552555chr7133502077537HLA-B44:13EEMRLEAERF0.99920.9546515
CALD1-EXOC4chr7134552555chr7133502077537HLA-B18:11EEMRLEAERF0.96350.6182515
CALD1-EXOC4chr7134552555chr7133502077537HLA-B18:03EEMRLEAERF0.9540.6154515
CALD1-EXOC4chr7134552555chr7133502077537HLA-B39:31ERFIQEIEHAL0.99990.93381223

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Potential FusionNeoAntigen Information of CALD1-EXOC4 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Fusion breakpoint peptide structures of CALD1-EXOC4

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
1961EMRLEAERFIQEIECALD1EXOC4chr7134552555chr7133502077537

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of CALD1-EXOC4

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B53:011A1O1961EMRLEAERFIQEIE-4.17128-4.28468
HLA-B53:011A1O1961EMRLEAERFIQEIE-3.4824-4.5177
HLA-B51:011E281961EMRLEAERFIQEIE-3.8039-3.9173
HLA-B51:011E281961EMRLEAERFIQEIE-3.0982-4.1335
HLA-B57:032BVO1961EMRLEAERFIQEIE-2.25252-3.28782
HLA-B57:032BVO1961EMRLEAERFIQEIE-1.1301-1.2435
HLA-A03:012XPG1961EMRLEAERFIQEIE-4.44786-4.56126
HLA-A03:012XPG1961EMRLEAERFIQEIE-4.14835-5.18365
HLA-B14:023BVN1961EMRLEAERFIQEIE-5.80238-5.91578
HLA-B14:023BVN1961EMRLEAERFIQEIE-3.55223-4.58753
HLA-B52:013W391961EMRLEAERFIQEIE-5.11856-5.23196
HLA-B52:013W391961EMRLEAERFIQEIE-3.25922-4.29452
HLA-B18:014JQV1961EMRLEAERFIQEIE-4.41315-4.52655
HLA-B18:014JQV1961EMRLEAERFIQEIE-3.36095-4.39625
HLA-A11:014UQ21961EMRLEAERFIQEIE-8.56989-8.68329
HLA-A11:014UQ21961EMRLEAERFIQEIE-6.72556-7.76086
HLA-A24:025HGA1961EMRLEAERFIQEIE-6.2734-6.3868
HLA-A24:025HGA1961EMRLEAERFIQEIE-4.24193-5.27723
HLA-B57:015VUD1961EMRLEAERFIQEIE-3.95679-4.99209
HLA-B57:015VUD1961EMRLEAERFIQEIE-2.97944-3.09284
HLA-C08:026JTP1961EMRLEAERFIQEIE-4.74128-4.85468
HLA-C08:026JTP1961EMRLEAERFIQEIE-2.44773-3.48303
HLA-B37:016MT41961EMRLEAERFIQEIE-3.77829-4.81359
HLA-B27:056PYJ1961EMRLEAERFIQEIE-3.40019-3.51359
HLA-B27:056PYJ1961EMRLEAERFIQEIE-1.99024-3.02554
HLA-B27:036PZ51961EMRLEAERFIQEIE-3.1249-3.2383
HLA-B27:036PZ51961EMRLEAERFIQEIE-0.148491-1.18379
HLA-B44:053DX81961EMRLEAERFIQEIE-5.76333-5.87673
HLA-B44:053DX81961EMRLEAERFIQEIE-3.98513-5.02043
HLA-B44:021M6O1961EMRLEAERFIQEIE-1.76802-2.80332
HLA-B07:025EO01961EMRLEAERFIQEIE-3.47003-3.58343
HLA-B07:025EO01961EMRLEAERFIQEIE0.983323-0.0519774
HLA-A02:016TDR1961EMRLEAERFIQEIE-2.71064-3.74594
HLA-A02:016TDR1961EMRLEAERFIQEIE-2.80613-2.91953

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Vaccine Design for the FusionNeoAntigens of CALD1-EXOC4

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
CALD1-EXOC4chr7134552555chr71335020771019EAERFIQEIAGCAGAAAGATTTATTCAGGAGATTGA
CALD1-EXOC4chr7134552555chr71335020771119AERFIQEIAGAAAGATTTATTCAGGAGATTGA
CALD1-EXOC4chr7134552555chr71335020771122AERFIQEIEHAAGAAAGATTTATTCAGGAGATTGAGCATGCTCT
CALD1-EXOC4chr7134552555chr71335020771222ERFIQEIEHAAAGATTTATTCAGGAGATTGAGCATGCTCT
CALD1-EXOC4chr7134552555chr71335020771223ERFIQEIEHALAAGATTTATTCAGGAGATTGAGCATGCTCTGGG
CALD1-EXOC4chr7134552555chr7133502077515EEMRLEAERFGGAGATGCGACTCGAAGCAGAAAGATTTAT
CALD1-EXOC4chr7134552555chr7133502077615EMRLEAERFGATGCGACTCGAAGCAGAAAGATTTAT
CALD1-EXOC4chr7134552555chr7133502077716MRLEAERFIGCGACTCGAAGCAGAAAGATTTATTCA

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence

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Information of the samples that have these potential fusion neoantigens of CALD1-EXOC4

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
OVCALD1-EXOC4chr7134552555ENST00000361388chr7133502077ENST00000253861TCGA-61-1998

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Potential target of CAR-T therapy development for CALD1-EXOC4

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to CALD1-EXOC4

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CALD1-EXOC4

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource