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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:ACER3-UVRAG

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ACER3-UVRAG
FusionPDB ID: 1299
FusionGDB2.0 ID: 1299
HgeneTgene
Gene symbol

ACER3

UVRAG

Gene ID

55331

7405

Gene namealkaline ceramidase 3UV radiation resistance associated
SynonymsAPHC|PHCA|PLDECODHTX|VPS38|p63
Cytomap

11q13.5

11q13.5

Type of geneprotein-codingprotein-coding
Descriptionalkaline ceramidase 3alkCDase 3alkaline CDase 3alkaline dihydroceramidase SB89alkaline phytoceramidasephytoceramidase, alkalineUV radiation resistance-associated gene proteinbeclin 1 binding proteindisrupted in heterotaxy
Modification date2020032020200313
UniProtAcc

Q9NUN7

Main function of 5'-partner protein: FUNCTION: Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:20068046, PubMed:26792856, PubMed:20207939, PubMed:11356846, PubMed:30575723). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:20068046). Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma (PubMed:20207939). Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function (By similarity). By regulating the levels of proinflammatory ceramides in immune cells and tissues, may modulate the inflammatory response (By similarity). {ECO:0000250|UniProtKB:Q9D099, ECO:0000269|PubMed:11356846, ECO:0000269|PubMed:20068046, ECO:0000269|PubMed:20207939, ECO:0000269|PubMed:26792856, ECO:0000269|PubMed:30575723, ECO:0000303|PubMed:20068046}.		.
Ensembl transtripts involved in fusion geneENST idsENST00000526597, ENST00000532485, 
ENST00000533873, ENST00000538157, 
ENST00000544113, ENST00000530182, 
ENST00000538870, ENST00000525872, 
ENST00000356136, ENST00000528420, 
ENST00000531818, ENST00000532130, 
ENST00000533454, ENST00000539288, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 7 X 7=68628 X 21 X 11=6468
# samples 1736
** MAII scorelog2(17/686*10)=-2.01267383003511
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(36/6468*10)=-4.16725086714399
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: ACER3 [Title/Abstract] AND UVRAG [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: ACER3 [Title/Abstract] AND UVRAG [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)UVRAG(75728024)-ACER3(76726060), # samples:3
ACER3(76730820)-UVRAG(75826968), # samples:2
Anticipated loss of major functional domain due to fusion event.ACER3-UVRAG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACER3-UVRAG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACER3-UVRAG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACER3-UVRAG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
UVRAG-ACER3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
UVRAG-ACER3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACER3

GO:0043067

regulation of programmed cell death

20068046

HgeneACER3

GO:0046512

sphingosine biosynthetic process

20068046

HgeneACER3

GO:0046514

ceramide catabolic process

30575723

HgeneACER3

GO:0071602

phytosphingosine biosynthetic process

11356846|20068046

TgeneUVRAG

GO:0071900

regulation of protein serine/threonine kinase activity

22542840

TgeneUVRAG

GO:0097352

autophagosome maturation

28306502

TgeneUVRAG

GO:0097680

double-strand break repair via classical nonhomologous end joining

22542840



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:75728024/chr11:76726060)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across ACER3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across UVRAG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000532485ACER3chr1176730820+ENST00000356136UVRAGchr1175826967+3431854801648522
ENST00000532485ACER3chr1176730820+ENST00000528420UVRAGchr1175826967+2030854801648522
ENST00000532485ACER3chr1176730820+ENST00000533454UVRAGchr1175826967+1736854801648522
ENST00000532485ACER3chr1176730820+ENST00000531818UVRAGchr1175826967+2887854801648522
ENST00000532485ACER3chr1176730820+ENST00000532130UVRAGchr1175826967+2019854801648522
ENST00000532485ACER3chr1176730820+ENST00000539288UVRAGchr1175826967+1736854801648522
ENST00000526597ACER3chr1176730820+ENST00000356136UVRAGchr1175826967+34198423621636424
ENST00000526597ACER3chr1176730820+ENST00000528420UVRAGchr1175826967+20188423621636424
ENST00000526597ACER3chr1176730820+ENST00000533454UVRAGchr1175826967+17248423621636424
ENST00000526597ACER3chr1176730820+ENST00000531818UVRAGchr1175826967+28758423621636424
ENST00000526597ACER3chr1176730820+ENST00000532130UVRAGchr1175826967+20078423621636424
ENST00000526597ACER3chr1176730820+ENST00000539288UVRAGchr1175826967+17248423621636424
ENST00000533873ACER3chr1176730820+ENST00000356136UVRAGchr1175826967+3251674111468485
ENST00000533873ACER3chr1176730820+ENST00000528420UVRAGchr1175826967+1850674111468485
ENST00000533873ACER3chr1176730820+ENST00000533454UVRAGchr1175826967+1556674111468485
ENST00000533873ACER3chr1176730820+ENST00000531818UVRAGchr1175826967+2707674111468485
ENST00000533873ACER3chr1176730820+ENST00000532130UVRAGchr1175826967+1839674111468485
ENST00000533873ACER3chr1176730820+ENST00000539288UVRAGchr1175826967+1556674111468485
ENST00000538157ACER3chr1176730820+ENST00000356136UVRAGchr1175826967+33988211911615474
ENST00000538157ACER3chr1176730820+ENST00000528420UVRAGchr1175826967+19978211911615474
ENST00000538157ACER3chr1176730820+ENST00000533454UVRAGchr1175826967+17038211911615474
ENST00000538157ACER3chr1176730820+ENST00000531818UVRAGchr1175826967+28548211911615474
ENST00000538157ACER3chr1176730820+ENST00000532130UVRAGchr1175826967+19868211911615474
ENST00000538157ACER3chr1176730820+ENST00000539288UVRAGchr1175826967+17038211911615474
ENST00000544113ACER3chr1176730820+ENST00000356136UVRAGchr1175826967+292835101145381
ENST00000544113ACER3chr1176730820+ENST00000528420UVRAGchr1175826967+152735101145381
ENST00000544113ACER3chr1176730820+ENST00000533454UVRAGchr1175826967+123335101145381
ENST00000544113ACER3chr1176730820+ENST00000531818UVRAGchr1175826967+238435101145381
ENST00000544113ACER3chr1176730820+ENST00000532130UVRAGchr1175826967+151635101145381
ENST00000544113ACER3chr1176730820+ENST00000539288UVRAGchr1175826967+123335101145381
ENST00000532485ACER3chr1176730820+ENST00000356136UVRAGchr1175826968+3431854801648522
ENST00000532485ACER3chr1176730820+ENST00000528420UVRAGchr1175826968+2030854801648522
ENST00000532485ACER3chr1176730820+ENST00000533454UVRAGchr1175826968+1736854801648522
ENST00000532485ACER3chr1176730820+ENST00000531818UVRAGchr1175826968+2887854801648522
ENST00000532485ACER3chr1176730820+ENST00000532130UVRAGchr1175826968+2019854801648522
ENST00000532485ACER3chr1176730820+ENST00000539288UVRAGchr1175826968+1736854801648522
ENST00000526597ACER3chr1176730820+ENST00000356136UVRAGchr1175826968+34198423621636424
ENST00000526597ACER3chr1176730820+ENST00000528420UVRAGchr1175826968+20188423621636424
ENST00000526597ACER3chr1176730820+ENST00000533454UVRAGchr1175826968+17248423621636424
ENST00000526597ACER3chr1176730820+ENST00000531818UVRAGchr1175826968+28758423621636424
ENST00000526597ACER3chr1176730820+ENST00000532130UVRAGchr1175826968+20078423621636424
ENST00000526597ACER3chr1176730820+ENST00000539288UVRAGchr1175826968+17248423621636424
ENST00000533873ACER3chr1176730820+ENST00000356136UVRAGchr1175826968+3251674111468485
ENST00000533873ACER3chr1176730820+ENST00000528420UVRAGchr1175826968+1850674111468485
ENST00000533873ACER3chr1176730820+ENST00000533454UVRAGchr1175826968+1556674111468485
ENST00000533873ACER3chr1176730820+ENST00000531818UVRAGchr1175826968+2707674111468485
ENST00000533873ACER3chr1176730820+ENST00000532130UVRAGchr1175826968+1839674111468485
ENST00000533873ACER3chr1176730820+ENST00000539288UVRAGchr1175826968+1556674111468485
ENST00000538157ACER3chr1176730820+ENST00000356136UVRAGchr1175826968+33988211911615474
ENST00000538157ACER3chr1176730820+ENST00000528420UVRAGchr1175826968+19978211911615474
ENST00000538157ACER3chr1176730820+ENST00000533454UVRAGchr1175826968+17038211911615474
ENST00000538157ACER3chr1176730820+ENST00000531818UVRAGchr1175826968+28548211911615474
ENST00000538157ACER3chr1176730820+ENST00000532130UVRAGchr1175826968+19868211911615474
ENST00000538157ACER3chr1176730820+ENST00000539288UVRAGchr1175826968+17038211911615474
ENST00000544113ACER3chr1176730820+ENST00000356136UVRAGchr1175826968+292835101145381
ENST00000544113ACER3chr1176730820+ENST00000528420UVRAGchr1175826968+152735101145381
ENST00000544113ACER3chr1176730820+ENST00000533454UVRAGchr1175826968+123335101145381
ENST00000544113ACER3chr1176730820+ENST00000531818UVRAGchr1175826968+238435101145381
ENST00000544113ACER3chr1176730820+ENST00000532130UVRAGchr1175826968+151635101145381
ENST00000544113ACER3chr1176730820+ENST00000539288UVRAGchr1175826968+123335101145381

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000532485ENST00000356136ACER3chr1176730820+UVRAGchr1175826967+0.0005428520.9994572
ENST00000532485ENST00000528420ACER3chr1176730820+UVRAGchr1175826967+0.0010342660.99896574
ENST00000532485ENST00000533454ACER3chr1176730820+UVRAGchr1175826967+0.001501520.99849844
ENST00000532485ENST00000531818ACER3chr1176730820+UVRAGchr1175826967+0.0005550070.999445
ENST00000532485ENST00000532130ACER3chr1176730820+UVRAGchr1175826967+0.0009883370.99901164
ENST00000532485ENST00000539288ACER3chr1176730820+UVRAGchr1175826967+0.001501520.99849844
ENST00000526597ENST00000356136ACER3chr1176730820+UVRAGchr1175826967+0.0015726810.9984274
ENST00000526597ENST00000528420ACER3chr1176730820+UVRAGchr1175826967+0.0031813360.99681866
ENST00000526597ENST00000533454ACER3chr1176730820+UVRAGchr1175826967+0.0044657630.9955342
ENST00000526597ENST00000531818ACER3chr1176730820+UVRAGchr1175826967+0.0016931770.9983069
ENST00000526597ENST00000532130ACER3chr1176730820+UVRAGchr1175826967+0.0030682720.9969317
ENST00000526597ENST00000539288ACER3chr1176730820+UVRAGchr1175826967+0.0044657630.9955342
ENST00000533873ENST00000356136ACER3chr1176730820+UVRAGchr1175826967+0.0011796540.99882036
ENST00000533873ENST00000528420ACER3chr1176730820+UVRAGchr1175826967+0.0024075250.9975924
ENST00000533873ENST00000533454ACER3chr1176730820+UVRAGchr1175826967+0.0036930670.9963069
ENST00000533873ENST00000531818ACER3chr1176730820+UVRAGchr1175826967+0.0012607890.9987392
ENST00000533873ENST00000532130ACER3chr1176730820+UVRAGchr1175826967+0.0022669760.997733
ENST00000533873ENST00000539288ACER3chr1176730820+UVRAGchr1175826967+0.0036930670.9963069
ENST00000538157ENST00000356136ACER3chr1176730820+UVRAGchr1175826967+0.0019290910.9980709
ENST00000538157ENST00000528420ACER3chr1176730820+UVRAGchr1175826967+0.0041704860.9958295
ENST00000538157ENST00000533454ACER3chr1176730820+UVRAGchr1175826967+0.0059304340.9940696
ENST00000538157ENST00000531818ACER3chr1176730820+UVRAGchr1175826967+0.002010670.9979893
ENST00000538157ENST00000532130ACER3chr1176730820+UVRAGchr1175826967+0.0039301310.9960699
ENST00000538157ENST00000539288ACER3chr1176730820+UVRAGchr1175826967+0.0059304340.9940696
ENST00000544113ENST00000356136ACER3chr1176730820+UVRAGchr1175826967+0.0038250210.99617493
ENST00000544113ENST00000528420ACER3chr1176730820+UVRAGchr1175826967+0.0100941260.9899059
ENST00000544113ENST00000533454ACER3chr1176730820+UVRAGchr1175826967+0.016532850.98346716
ENST00000544113ENST00000531818ACER3chr1176730820+UVRAGchr1175826967+0.0044668440.9955331
ENST00000544113ENST00000532130ACER3chr1176730820+UVRAGchr1175826967+0.0095785110.99042153
ENST00000544113ENST00000539288ACER3chr1176730820+UVRAGchr1175826967+0.016532850.98346716
ENST00000532485ENST00000356136ACER3chr1176730820+UVRAGchr1175826968+0.0005428520.9994572
ENST00000532485ENST00000528420ACER3chr1176730820+UVRAGchr1175826968+0.0010342660.99896574
ENST00000532485ENST00000533454ACER3chr1176730820+UVRAGchr1175826968+0.001501520.99849844
ENST00000532485ENST00000531818ACER3chr1176730820+UVRAGchr1175826968+0.0005550070.999445
ENST00000532485ENST00000532130ACER3chr1176730820+UVRAGchr1175826968+0.0009883370.99901164
ENST00000532485ENST00000539288ACER3chr1176730820+UVRAGchr1175826968+0.001501520.99849844
ENST00000526597ENST00000356136ACER3chr1176730820+UVRAGchr1175826968+0.0015726810.9984274
ENST00000526597ENST00000528420ACER3chr1176730820+UVRAGchr1175826968+0.0031813360.99681866
ENST00000526597ENST00000533454ACER3chr1176730820+UVRAGchr1175826968+0.0044657630.9955342
ENST00000526597ENST00000531818ACER3chr1176730820+UVRAGchr1175826968+0.0016931770.9983069
ENST00000526597ENST00000532130ACER3chr1176730820+UVRAGchr1175826968+0.0030682720.9969317
ENST00000526597ENST00000539288ACER3chr1176730820+UVRAGchr1175826968+0.0044657630.9955342
ENST00000533873ENST00000356136ACER3chr1176730820+UVRAGchr1175826968+0.0011796540.99882036
ENST00000533873ENST00000528420ACER3chr1176730820+UVRAGchr1175826968+0.0024075250.9975924
ENST00000533873ENST00000533454ACER3chr1176730820+UVRAGchr1175826968+0.0036930670.9963069
ENST00000533873ENST00000531818ACER3chr1176730820+UVRAGchr1175826968+0.0012607890.9987392
ENST00000533873ENST00000532130ACER3chr1176730820+UVRAGchr1175826968+0.0022669760.997733
ENST00000533873ENST00000539288ACER3chr1176730820+UVRAGchr1175826968+0.0036930670.9963069
ENST00000538157ENST00000356136ACER3chr1176730820+UVRAGchr1175826968+0.0019290910.9980709
ENST00000538157ENST00000528420ACER3chr1176730820+UVRAGchr1175826968+0.0041704860.9958295
ENST00000538157ENST00000533454ACER3chr1176730820+UVRAGchr1175826968+0.0059304340.9940696
ENST00000538157ENST00000531818ACER3chr1176730820+UVRAGchr1175826968+0.002010670.9979893
ENST00000538157ENST00000532130ACER3chr1176730820+UVRAGchr1175826968+0.0039301310.9960699
ENST00000538157ENST00000539288ACER3chr1176730820+UVRAGchr1175826968+0.0059304340.9940696
ENST00000544113ENST00000356136ACER3chr1176730820+UVRAGchr1175826968+0.0038250210.99617493
ENST00000544113ENST00000528420ACER3chr1176730820+UVRAGchr1175826968+0.0100941260.9899059
ENST00000544113ENST00000533454ACER3chr1176730820+UVRAGchr1175826968+0.016532850.98346716
ENST00000544113ENST00000531818ACER3chr1176730820+UVRAGchr1175826968+0.0044668440.9955331
ENST00000544113ENST00000532130ACER3chr1176730820+UVRAGchr1175826968+0.0095785110.99042153
ENST00000544113ENST00000539288ACER3chr1176730820+UVRAGchr1175826968+0.016532850.98346716

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for ACER3-UVRAG

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
ACER3chr1176730820UVRAGchr1175826967351117TRTLYLRYRPKVKLRYQHGLGTPDLR
ACER3chr1176730820UVRAGchr1175826967674221TRTLYLRYRPKVKLRYQHGLGTPDLR
ACER3chr1176730820UVRAGchr1175826967821210TRTLYLRYRPKVKLRYQHGLGTPDLR
ACER3chr1176730820UVRAGchr1175826967842160TRTLYLRYRPKVKLRYQHGLGTPDLR
ACER3chr1176730820UVRAGchr1175826967854258TRTLYLRYRPKVKLRYQHGLGTPDLR
ACER3chr1176730820UVRAGchr1175826968351117TRTLYLRYRPKVKLRYQHGLGTPDLR
ACER3chr1176730820UVRAGchr1175826968674221TRTLYLRYRPKVKLRYQHGLGTPDLR
ACER3chr1176730820UVRAGchr1175826968821210TRTLYLRYRPKVKLRYQHGLGTPDLR
ACER3chr1176730820UVRAGchr1175826968842160TRTLYLRYRPKVKLRYQHGLGTPDLR
ACER3chr1176730820UVRAGchr1175826968854258TRTLYLRYRPKVKLRYQHGLGTPDLR

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Potential FusionNeoAntigen Information of ACER3-UVRAG in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
ACER3-UVRAG_76730820_75826967.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:04LRYRPKVKL0.99920.9068514
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:02LRYRPKVKL0.99920.9033514
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:07LRYRPKVKL0.99910.5554514
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:05LRYRPKVKL0.99890.9739514
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:04YRPKVKLRY0.99150.7094716
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:02YRPKVKLRY0.99140.5565716
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:05YRPKVKLRY0.99010.8622716
ACER3-UVRAGchr1176730820chr1175826967842HLA-B14:02LRYRPKVKL0.95250.8285514
ACER3-UVRAGchr1176730820chr1175826967842HLA-B14:01LRYRPKVKL0.95250.8285514
ACER3-UVRAGchr1176730820chr1175826967842HLA-B39:24LRYRPKVKL0.75950.606514
ACER3-UVRAGchr1176730820chr1175826967842HLA-B39:06LRYRPKVKL0.71120.8769514
ACER3-UVRAGchr1176730820chr1175826967842HLA-B39:01LRYRPKVKL0.51680.9756514
ACER3-UVRAGchr1176730820chr1175826967842HLA-B48:01LRYRPKVKL0.42280.5323514
ACER3-UVRAGchr1176730820chr1175826967842HLA-B38:02LRYRPKVKL0.34130.9902514
ACER3-UVRAGchr1176730820chr1175826967842HLA-B15:18YRPKVKLRY0.26340.5276716
ACER3-UVRAGchr1176730820chr1175826967842HLA-B15:37LRYRPKVKL0.2030.8006514
ACER3-UVRAGchr1176730820chr1175826967842HLA-B15:10LRYRPKVKL0.18870.7526514
ACER3-UVRAGchr1176730820chr1175826967842HLA-B07:10LRYRPKVKL0.01150.5926514
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:05LRYRPKVKLR0.99940.8503515
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:04RYRPKVKLRY0.99120.7843616
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:02RYRPKVKLRY0.99050.6338616
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:05YLRYRPKVKL0.92350.9541414
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:02YLRYRPKVKL0.910.8135414
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:04YLRYRPKVKL0.90410.9063414
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:05LRYRPKVKLRY0.99990.9232516
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:02LRYRPKVKLRY0.99990.7423516
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:04LRYRPKVKLRY0.99990.828516
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:05RYRPKVKL0.95260.9763614
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:14LRYRPKVKL0.99920.9432514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:05LRYRPKVKL0.99260.9838514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:95LRYRPKVKL0.99190.8783514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:27LRYRPKVKL0.98710.9781514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:95YRPKVKLRY0.9730.5183716
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:03LRYRPKVKL0.96620.9768514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:13LRYRPKVKL0.96390.9772514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:29LRYRPKVKL0.9630.9703514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:46LRYRPKVKL0.95660.9392514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:27YRPKVKLRY0.9560.8745716
ACER3-UVRAGchr1176730820chr1175826967842HLA-B73:01LRYRPKVKL0.93660.7374514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:05YRPKVKLRY0.93550.8915716
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:19LRYRPKVKL0.93150.864514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:10LRYRPKVKL0.92760.9794514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:80LRYRPKVKL0.92330.9726514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:67LRYRPKVKL0.92330.9726514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:29YRPKVKLRY0.91020.8614716
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:03YRPKVKLRY0.87990.8812716
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:46YRPKVKLRY0.87410.6906716
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:67YRPKVKLRY0.79280.8375716
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:80YRPKVKLRY0.79280.8375716
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:10YRPKVKLRY0.78290.8727716
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:13YRPKVKLRY0.68780.8583716
ACER3-UVRAGchr1176730820chr1175826967842HLA-B39:09LRYRPKVKL0.59530.8368514
ACER3-UVRAGchr1176730820chr1175826967842HLA-B39:12LRYRPKVKL0.54190.9773514
ACER3-UVRAGchr1176730820chr1175826967842HLA-B14:03LRYRPKVKL0.45390.9116514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C12:16LRYRPKVKL0.04570.9867514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C12:16YRPKVKLRY0.01150.9095716
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:14LRYRPKVKLR0.99920.8324515
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:03LRYRPKVKLR0.96590.8598515
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:14YLRYRPKVKL0.92660.9245414
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:19RYRPKVKLRY0.90910.5558616
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:10RYRPKVKLRY0.88050.9427616
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:46RYRPKVKLRY0.8760.8182616
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:67RYRPKVKLRY0.87520.9082616
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:80RYRPKVKLRY0.87520.9082616
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:03RYRPKVKLRY0.85270.8634616
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:14KLRYQHGLGT0.84740.70781222
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:05YLRYRPKVKL0.61880.9676414
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:03YLRYRPKVKL0.37260.9597414
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:03LRYRPKVKLRY0.99850.9313516
ACER3-UVRAGchr1176730820chr1175826967842HLA-C06:06RYRPKVKL0.92970.9927614
ACER3-UVRAGchr1176730820chr1175826967842HLA-C14:03RYRPKVKL0.88850.9585614
ACER3-UVRAGchr1176730820chr1175826967842HLA-C14:02RYRPKVKL0.88850.9585614
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:06LRYRPKVKL0.99950.9086514
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:10LRYRPKVKL0.99920.9582514
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:08LRYRPKVKL0.99890.9435514
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:09LRYRPKVKL0.99870.969514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:01LRYRPKVKL0.9950.8567514
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:08YRPKVKLRY0.98960.7178716
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:10YRPKVKLRY0.98950.8295716
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:17LRYRPKVKL0.95760.9803514
ACER3-UVRAGchr1176730820chr1175826967842HLA-A30:01RYRPKVKLR0.93080.882615
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:02LRYRPKVKL0.92330.9726514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:17YRPKVKLRY0.91010.8918716
ACER3-UVRAGchr1176730820chr1175826967842HLA-C06:08LRYRPKVKL0.82530.9963514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:22LRYRPKVKL0.80640.9026514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:02YRPKVKLRY0.79280.8375716
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:22YRPKVKLRY0.75140.5267716
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:04LRYRPKVKL0.70210.9453514
ACER3-UVRAGchr1176730820chr1175826967842HLA-B39:31LRYRPKVKL0.52640.9762514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C06:08YRPKVKLRY0.3390.959716
ACER3-UVRAGchr1176730820chr1175826967842HLA-C06:06LRYRPKVKL0.24730.995514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C03:67LRYRPKVKL0.12710.9886514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C06:02LRYRPKVKL0.09930.9973514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C06:17LRYRPKVKL0.09930.9973514
ACER3-UVRAGchr1176730820chr1175826967842HLA-C06:06YRPKVKLRY0.02230.9734716
ACER3-UVRAGchr1176730820chr1175826967842HLA-B15:54YRPKVKLRY0.01720.7399716
ACER3-UVRAGchr1176730820chr1175826967842HLA-C06:17YRPKVKLRY0.00180.9707716
ACER3-UVRAGchr1176730820chr1175826967842HLA-C06:02YRPKVKLRY0.00180.9707716
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:10LRYRPKVKLR0.99850.9171515
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:10RYRPKVKLRY0.99280.8906616
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:08YLRYRPKVKL0.90790.8971414
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:10YLRYRPKVKL0.9060.9536414
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:02RYRPKVKLRY0.87520.9082616
ACER3-UVRAGchr1176730820chr1175826967842HLA-C06:02YLRYRPKVKL0.8610.997414
ACER3-UVRAGchr1176730820chr1175826967842HLA-C06:17YLRYRPKVKL0.8610.997414
ACER3-UVRAGchr1176730820chr1175826967842HLA-A30:01RYRPKVKLRY0.85530.7955616
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:09YLRYRPKVKL0.83380.9384414
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:06YLRYRPKVKL0.82840.9065414
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:22YLRYRPKVKL0.76010.867414
ACER3-UVRAGchr1176730820chr1175826967842HLA-C07:01YLRYRPKVKL0.62290.7518414
ACER3-UVRAGchr1176730820chr1175826967842HLA-C06:08YLRYRPKVKL0.60770.9957414
ACER3-UVRAGchr1176730820chr1175826967842HLA-B27:10LRYRPKVKLRY0.99990.9218516

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Potential FusionNeoAntigen Information of ACER3-UVRAG in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
ACER3-UVRAG_76730820_75826967.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
ACER3-UVRAGchr1176730820chr1175826967842DRB1-0102PKVKLRYQHGLGTPD924
ACER3-UVRAGchr1176730820chr1175826967842DRB1-0102KVKLRYQHGLGTPDL1025
ACER3-UVRAGchr1176730820chr1175826967842DRB1-0109PKVKLRYQHGLGTPD924
ACER3-UVRAGchr1176730820chr1175826967842DRB1-0109KVKLRYQHGLGTPDL1025
ACER3-UVRAGchr1176730820chr1175826967842DRB1-0115PKVKLRYQHGLGTPD924
ACER3-UVRAGchr1176730820chr1175826967842DRB1-0115KVKLRYQHGLGTPDL1025
ACER3-UVRAGchr1176730820chr1175826967842DRB1-0123PKVKLRYQHGLGTPD924
ACER3-UVRAGchr1176730820chr1175826967842DRB1-0123KVKLRYQHGLGTPDL1025
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1111YLRYRPKVKLRYQHG419
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1111LYLRYRPKVKLRYQH318
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1111TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1111LRYRPKVKLRYQHGL520
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1114YLRYRPKVKLRYQHG419
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1114LYLRYRPKVKLRYQH318
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1114TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1114LRYRPKVKLRYQHGL520
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1120YLRYRPKVKLRYQHG419
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1120LYLRYRPKVKLRYQH318
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1120TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1120LRYRPKVKLRYQHGL520
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1168YLRYRPKVKLRYQHG419
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1168LYLRYRPKVKLRYQH318
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1168TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1168LRYRPKVKLRYQHGL520
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1170TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1172YLRYRPKVKLRYQHG419
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1186YLRYRPKVKLRYQHG419
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1186LYLRYRPKVKLRYQH318
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1186TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1186LRYRPKVKLRYQHGL520
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1302YLRYRPKVKLRYQHG419
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1302LYLRYRPKVKLRYQH318
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1302TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1302LRYRPKVKLRYQHGL520
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1315TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1316YLRYRPKVKLRYQHG419
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1316LYLRYRPKVKLRYQH318
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1316TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1316LRYRPKVKLRYQHGL520
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1323YLRYRPKVKLRYQHG419
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1323LYLRYRPKVKLRYQH318
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1323TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1323LRYRPKVKLRYQHGL520
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1329YLRYRPKVKLRYQHG419
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1329LYLRYRPKVKLRYQH318
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1329TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1329LRYRPKVKLRYQHGL520
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1331YLRYRPKVKLRYQHG419
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1331LYLRYRPKVKLRYQH318
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1331TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1334YLRYRPKVKLRYQHG419
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1334LYLRYRPKVKLRYQH318
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1334TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1334LRYRPKVKLRYQHGL520
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1336YLRYRPKVKLRYQHG419
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1336LYLRYRPKVKLRYQH318
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1336TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1338YLRYRPKVKLRYQHG419
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1339YLRYRPKVKLRYQHG419
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1339LYLRYRPKVKLRYQH318
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1339TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1339LRYRPKVKLRYQHGL520
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1341YLRYRPKVKLRYQHG419
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1341LYLRYRPKVKLRYQH318
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1341TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1341LRYRPKVKLRYQHGL520
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1343TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1357TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1363YLRYRPKVKLRYQHG419
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1363LYLRYRPKVKLRYQH318
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1363TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1363LRYRPKVKLRYQHGL520
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1365YLRYRPKVKLRYQHG419
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1373YLRYRPKVKLRYQHG419
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1373LYLRYRPKVKLRYQH318
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1373TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1373LRYRPKVKLRYQHGL520
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1374YLRYRPKVKLRYQHG419
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1374LYLRYRPKVKLRYQH318
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1374TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1374LRYRPKVKLRYQHGL520
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1396YLRYRPKVKLRYQHG419
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1396LYLRYRPKVKLRYQH318
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1396TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1396LRYRPKVKLRYQHGL520
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1397YLRYRPKVKLRYQHG419
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1397LYLRYRPKVKLRYQH318
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1397TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1397LRYRPKVKLRYQHGL520
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1399YLRYRPKVKLRYQHG419
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1399LYLRYRPKVKLRYQH318
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1399TLYLRYRPKVKLRYQ217
ACER3-UVRAGchr1176730820chr1175826967842DRB1-1399LRYRPKVKLRYQHGL520
ACER3-UVRAGchr1176730820chr1175826967842DRB5-0103RTLYLRYRPKVKLRY116

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Fusion breakpoint peptide structures of ACER3-UVRAG

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
8360RYRPKVKLRYQHGLACER3UVRAGchr1176730820chr1175826967842

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of ACER3-UVRAG

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN8360RYRPKVKLRYQHGL-7.15543-7.26883
HLA-B14:023BVN8360RYRPKVKLRYQHGL-4.77435-5.80965
HLA-B52:013W398360RYRPKVKLRYQHGL-6.80875-6.92215
HLA-B52:013W398360RYRPKVKLRYQHGL-4.20386-5.23916
HLA-A11:014UQ28360RYRPKVKLRYQHGL-7.5194-8.5547
HLA-A11:014UQ28360RYRPKVKLRYQHGL-6.9601-7.0735
HLA-A24:025HGA8360RYRPKVKLRYQHGL-7.52403-7.63743
HLA-A24:025HGA8360RYRPKVKLRYQHGL-5.82433-6.85963
HLA-B27:056PYJ8360RYRPKVKLRYQHGL-3.28285-4.31815
HLA-B44:053DX88360RYRPKVKLRYQHGL-5.91172-6.94702
HLA-B44:053DX88360RYRPKVKLRYQHGL-4.24346-4.35686

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Vaccine Design for the FusionNeoAntigens of ACER3-UVRAG

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
ACER3-UVRAGchr1176730820chr11758269671222KLRYQHGLGTAAGCTAAGATATCAACATGGACTAGGGACT
ACER3-UVRAGchr1176730820chr1175826967414YLRYRPKVKLTACCTGAGATATAGGCCAAAAGTGAAGCTA
ACER3-UVRAGchr1176730820chr1175826967514LRYRPKVKLCTGAGATATAGGCCAAAAGTGAAGCTA
ACER3-UVRAGchr1176730820chr1175826967515LRYRPKVKLRCTGAGATATAGGCCAAAAGTGAAGCTAAGA
ACER3-UVRAGchr1176730820chr1175826967516LRYRPKVKLRYCTGAGATATAGGCCAAAAGTGAAGCTAAGATAT
ACER3-UVRAGchr1176730820chr1175826967614RYRPKVKLAGATATAGGCCAAAAGTGAAGCTA
ACER3-UVRAGchr1176730820chr1175826967615RYRPKVKLRAGATATAGGCCAAAAGTGAAGCTAAGA
ACER3-UVRAGchr1176730820chr1175826967616RYRPKVKLRYAGATATAGGCCAAAAGTGAAGCTAAGATAT
ACER3-UVRAGchr1176730820chr1175826967716YRPKVKLRYTATAGGCCAAAAGTGAAGCTAAGATAT

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
ACER3-UVRAGchr1176730820chr1175826967116RTLYLRYRPKVKLRYAGAACACTTTACCTGAGATATAGGCCAAAAGTGAAGCTAAGATAT
ACER3-UVRAGchr1176730820chr11758269671025KVKLRYQHGLGTPDLAAAGTGAAGCTAAGATATCAACATGGACTAGGGACTCCAGACTTG
ACER3-UVRAGchr1176730820chr1175826967217TLYLRYRPKVKLRYQACACTTTACCTGAGATATAGGCCAAAAGTGAAGCTAAGATATCAA
ACER3-UVRAGchr1176730820chr1175826967318LYLRYRPKVKLRYQHCTTTACCTGAGATATAGGCCAAAAGTGAAGCTAAGATATCAACAT
ACER3-UVRAGchr1176730820chr1175826967419YLRYRPKVKLRYQHGTACCTGAGATATAGGCCAAAAGTGAAGCTAAGATATCAACATGGA
ACER3-UVRAGchr1176730820chr1175826967520LRYRPKVKLRYQHGLCTGAGATATAGGCCAAAAGTGAAGCTAAGATATCAACATGGACTA
ACER3-UVRAGchr1176730820chr1175826967924PKVKLRYQHGLGTPDCCAAAAGTGAAGCTAAGATATCAACATGGACTAGGGACTCCAGAC

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Information of the samples that have these potential fusion neoantigens of ACER3-UVRAG

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
BRCAACER3-UVRAGchr1176730820ENST00000526597chr1175826967ENST00000356136TCGA-E2-A109

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Potential target of CAR-T therapy development for ACER3-UVRAG

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACER3chr11:76730820chr11:75826967ENST00000532485+1011119_139250268.0TransmembraneHelical
HgeneACER3chr11:76730820chr11:75826967ENST00000532485+1011142_162250268.0TransmembraneHelical
HgeneACER3chr11:76730820chr11:75826967ENST00000532485+1011174_194250268.0TransmembraneHelical
HgeneACER3chr11:76730820chr11:75826967ENST00000532485+1011216_236250268.0TransmembraneHelical
HgeneACER3chr11:76730820chr11:75826967ENST00000532485+101134_55250268.0TransmembraneHelical
HgeneACER3chr11:76730820chr11:75826967ENST00000532485+101162_82250268.0TransmembraneHelical
HgeneACER3chr11:76730820chr11:75826967ENST00000532485+101188_108250268.0TransmembraneHelical
HgeneACER3chr11:76730820chr11:75826967ENST00000544113+5634_55117135.0TransmembraneHelical
HgeneACER3chr11:76730820chr11:75826967ENST00000544113+5662_82117135.0TransmembraneHelical
HgeneACER3chr11:76730820chr11:75826967ENST00000544113+5688_108117135.0TransmembraneHelical
HgeneACER3chr11:76730820chr11:75826968ENST00000532485+1011119_139250268.0TransmembraneHelical
HgeneACER3chr11:76730820chr11:75826968ENST00000532485+1011142_162250268.0TransmembraneHelical
HgeneACER3chr11:76730820chr11:75826968ENST00000532485+1011174_194250268.0TransmembraneHelical
HgeneACER3chr11:76730820chr11:75826968ENST00000532485+1011216_236250268.0TransmembraneHelical
HgeneACER3chr11:76730820chr11:75826968ENST00000532485+101134_55250268.0TransmembraneHelical
HgeneACER3chr11:76730820chr11:75826968ENST00000532485+101162_82250268.0TransmembraneHelical
HgeneACER3chr11:76730820chr11:75826968ENST00000532485+101188_108250268.0TransmembraneHelical
HgeneACER3chr11:76730820chr11:75826968ENST00000544113+5634_55117135.0TransmembraneHelical
HgeneACER3chr11:76730820chr11:75826968ENST00000544113+5662_82117135.0TransmembraneHelical
HgeneACER3chr11:76730820chr11:75826968ENST00000544113+5688_108117135.0TransmembraneHelical

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to ACER3-UVRAG

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ACER3-UVRAG

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource