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Fusion Protein:CDK14-PUM2

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CDK14-PUM2
	FusionPDB ID: 15181
	FusionGDB2.0 ID: 15181
		Hgene	Tgene
	Gene symbol	CDK14	PUM2
	Gene ID	5218	23369
	Gene name	cyclin dependent kinase 14	pumilio RNA binding family member 2
	Synonyms	PFTAIRE1\|PFTK1	PUMH2\|PUML2
	Cytomap	7q21.13	2p24.1
	Type of gene	protein-coding	protein-coding
	Description	cyclin-dependent kinase 14PFTAIRE protein kinase 1cell division protein kinase 14serine/threonine-protein kinase PFTAIRE-1	pumilio homolog 2pumilio-2
	Modification date	20200313	20200313
	UniProtAcc	O94921 Main function of 5'-partner protein: FUNCTION: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. {ECO:0000269\|PubMed:16461467, ECO:0000269\|PubMed:17517622, ECO:0000269\|PubMed:19524571, ECO:0000269\|PubMed:20059949}.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000265741, ENST00000380050, ENST00000406263, ENST00000436577, ENST00000496279,	ENST00000420234, ENST00000319801, ENST00000338086, ENST00000361078, ENST00000403432, ENST00000536417,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	17 X 13 X 8=1768	11 X 9 X 5=495
	# samples	18	13
	** MAII score	log2(18/1768*10)=-3.29604946306176 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/495*10)=-1.92891690193852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: CDK14 [Title/Abstract] AND PUM2 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: CDK14 [Title/Abstract] AND PUM2 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CDK14(90547039)-PUM2(20483247), # samples:1
Anticipated loss of major functional domain due to fusion event.	CDK14-PUM2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CDK14-PUM2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CDK14-PUM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CDK14-PUM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CDK14	GO:0000086	G2/M transition of mitotic cell cycle	20059949
Hgene	CDK14	GO:0060828	regulation of canonical Wnt signaling pathway	20059949
Tgene	PUM2	GO:0010608	posttranscriptional regulation of gene expression	25100735
Tgene	PUM2	GO:0043488	regulation of mRNA stability	26724866
Tgene	PUM2	GO:0051983	regulation of chromosome segregation	26724866
Tgene	PUM2	GO:1900246	positive regulation of RIG-I signaling pathway	25340845

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:90547039/chr2:20483247)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across CDK14 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PUM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000380050	CDK14	chr7	90547039	+	ENST00000338086	PUM2	chr2	20483247	-	5755	957	77	2860	927
ENST00000380050	CDK14	chr7	90547039	+	ENST00000319801	PUM2	chr2	20483247	-	5523	957	77	2629	850
ENST00000380050	CDK14	chr7	90547039	+	ENST00000361078	PUM2	chr2	20483247	-	5760	957	77	2866	929
ENST00000380050	CDK14	chr7	90547039	+	ENST00000536417	PUM2	chr2	20483247	-	3136	957	77	2860	927
ENST00000380050	CDK14	chr7	90547039	+	ENST00000403432	PUM2	chr2	20483247	-	3136	957	77	2860	927
ENST00000265741	CDK14	chr7	90547039	+	ENST00000338086	PUM2	chr2	20483247	-	5714	916	144	2819	891
ENST00000265741	CDK14	chr7	90547039	+	ENST00000319801	PUM2	chr2	20483247	-	5482	916	144	2588	814
ENST00000265741	CDK14	chr7	90547039	+	ENST00000361078	PUM2	chr2	20483247	-	5719	916	144	2825	893
ENST00000265741	CDK14	chr7	90547039	+	ENST00000536417	PUM2	chr2	20483247	-	3095	916	144	2819	891
ENST00000265741	CDK14	chr7	90547039	+	ENST00000403432	PUM2	chr2	20483247	-	3095	916	144	2819	891
ENST00000406263	CDK14	chr7	90547039	+	ENST00000338086	PUM2	chr2	20483247	-	5928	1130	442	3033	863
ENST00000406263	CDK14	chr7	90547039	+	ENST00000319801	PUM2	chr2	20483247	-	5696	1130	442	2802	786
ENST00000406263	CDK14	chr7	90547039	+	ENST00000361078	PUM2	chr2	20483247	-	5933	1130	442	3039	865
ENST00000406263	CDK14	chr7	90547039	+	ENST00000536417	PUM2	chr2	20483247	-	3309	1130	442	3033	863
ENST00000406263	CDK14	chr7	90547039	+	ENST00000403432	PUM2	chr2	20483247	-	3309	1130	442	3033	863
ENST00000436577	CDK14	chr7	90547039	+	ENST00000338086	PUM2	chr2	20483247	-	5502	704	256	2607	783
ENST00000436577	CDK14	chr7	90547039	+	ENST00000319801	PUM2	chr2	20483247	-	5270	704	256	2376	706
ENST00000436577	CDK14	chr7	90547039	+	ENST00000361078	PUM2	chr2	20483247	-	5507	704	256	2613	785
ENST00000436577	CDK14	chr7	90547039	+	ENST00000536417	PUM2	chr2	20483247	-	2883	704	256	2607	783
ENST00000436577	CDK14	chr7	90547039	+	ENST00000403432	PUM2	chr2	20483247	-	2883	704	256	2607	783

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000380050	ENST00000338086	CDK14	chr7	90547039	+	PUM2	chr2	20483247	-	0.000231225	0.9997688
ENST00000380050	ENST00000319801	CDK14	chr7	90547039	+	PUM2	chr2	20483247	-	0.000271482	0.9997285
ENST00000380050	ENST00000361078	CDK14	chr7	90547039	+	PUM2	chr2	20483247	-	0.000193422	0.9998066
ENST00000380050	ENST00000536417	CDK14	chr7	90547039	+	PUM2	chr2	20483247	-	0.003805456	0.9961946
ENST00000380050	ENST00000403432	CDK14	chr7	90547039	+	PUM2	chr2	20483247	-	0.003805456	0.9961946
ENST00000265741	ENST00000338086	CDK14	chr7	90547039	+	PUM2	chr2	20483247	-	0.00013344	0.9998665
ENST00000265741	ENST00000319801	CDK14	chr7	90547039	+	PUM2	chr2	20483247	-	0.000149335	0.99985063
ENST00000265741	ENST00000361078	CDK14	chr7	90547039	+	PUM2	chr2	20483247	-	0.000126145	0.9998739
ENST00000265741	ENST00000536417	CDK14	chr7	90547039	+	PUM2	chr2	20483247	-	0.002655935	0.9973441
ENST00000265741	ENST00000403432	CDK14	chr7	90547039	+	PUM2	chr2	20483247	-	0.002655935	0.9973441
ENST00000406263	ENST00000338086	CDK14	chr7	90547039	+	PUM2	chr2	20483247	-	0.000150737	0.9998492
ENST00000406263	ENST00000319801	CDK14	chr7	90547039	+	PUM2	chr2	20483247	-	0.000111156	0.9998888
ENST00000406263	ENST00000361078	CDK14	chr7	90547039	+	PUM2	chr2	20483247	-	0.00012674	0.9998733
ENST00000406263	ENST00000536417	CDK14	chr7	90547039	+	PUM2	chr2	20483247	-	0.002195517	0.99780446
ENST00000406263	ENST00000403432	CDK14	chr7	90547039	+	PUM2	chr2	20483247	-	0.002195517	0.99780446
ENST00000436577	ENST00000338086	CDK14	chr7	90547039	+	PUM2	chr2	20483247	-	0.000777506	0.9992225
ENST00000436577	ENST00000319801	CDK14	chr7	90547039	+	PUM2	chr2	20483247	-	0.000591458	0.9994086
ENST00000436577	ENST00000361078	CDK14	chr7	90547039	+	PUM2	chr2	20483247	-	0.000657603	0.9993424
ENST00000436577	ENST00000536417	CDK14	chr7	90547039	+	PUM2	chr2	20483247	-	0.009850368	0.9901496
ENST00000436577	ENST00000403432	CDK14	chr7	90547039	+	PUM2	chr2	20483247	-	0.009850368	0.9901496

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for CDK14-PUM2

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
CDK14	chr7	90547039	PUM2	chr2	20483247	1130	229	LISDTGELKLADFGYQVLAPTAYYDQ
CDK14	chr7	90547039	PUM2	chr2	20483247	704	149	LISDTGELKLADFGYQVLAPTAYYDQ
CDK14	chr7	90547039	PUM2	chr2	20483247	916	257	LISDTGELKLADFGYQVLAPTAYYDQ
CDK14	chr7	90547039	PUM2	chr2	20483247	957	293	LISDTGELKLADFGYQVLAPTAYYDQ

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Potential FusionNeoAntigen Information of CDK14-PUM2 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

CDK14-PUM2_90547039_20483247.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:22	KLADFGYQV	0.9995	0.6882	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:60	KLADFGYQV	0.9994	0.7261	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:67	KLADFGYQV	0.9994	0.7521	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:11	KLADFGYQV	0.9994	0.7914	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:30	KLADFGYQV	0.9994	0.7521	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:24	KLADFGYQV	0.9994	0.7521	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:21	KLADFGYQV	0.9993	0.8358	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:16	KLADFGYQV	0.9993	0.753	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:27	KLADFGYQV	0.9992	0.736	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:38	KLADFGYQV	0.999	0.717	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:13	KLADFGYQV	0.999	0.8028	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:19	KLADFGYQV	0.9984	0.5016	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:04	KLADFGYQV	0.9958	0.9331	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:17	KLADFGYQV	0.9951	0.8376	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:35	KLADFGYQV	0.9937	0.7796	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:29	KLADFGYQV	0.991	0.7577	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:20	KLADFGYQV	0.9801	0.7592	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B35:03	LADFGYQVL	0.9635	0.9743	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B45:01	ADFGYQVLA	0.9248	0.8809	10	19
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B50:02	ADFGYQVLA	0.8876	0.8328	10	19
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B15:02	ELKLADFGY	0.878	0.8375	6	15
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B35:04	LADFGYQVL	0.8506	0.9882	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B35:02	LADFGYQVL	0.8506	0.9882	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B50:01	ADFGYQVLA	0.6091	0.9568	10	19
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A32:13	KLADFGYQV	0.5851	0.9747	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B41:01	ADFGYQVLA	0.5174	0.9501	10	19
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B13:02	KLADFGYQV	0.3066	0.9953	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B13:01	KLADFGYQV	0.276	0.9984	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:22	KLADFGYQVL	0.9988	0.6441	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B44:03	GELKLADFGY	0.9983	0.9407	5	15
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:13	KLADFGYQVL	0.9982	0.8247	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:24	KLADFGYQVL	0.9976	0.7249	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:67	KLADFGYQVL	0.9976	0.7249	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:30	KLADFGYQVL	0.9976	0.7249	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:11	KLADFGYQVL	0.9976	0.7578	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:60	KLADFGYQVL	0.9975	0.7128	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:04	KLADFGYQVL	0.9973	0.8779	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:17	KLADFGYQVL	0.9972	0.7683	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:27	KLADFGYQVL	0.9971	0.7384	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:16	KLADFGYQVL	0.9963	0.6507	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:38	KLADFGYQVL	0.9924	0.7592	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:35	KLADFGYQVL	0.9552	0.7492	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:22	LKLADFGYQV	0.8896	0.6428	7	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:29	KLADFGYQVL	0.8804	0.7305	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:20	KLADFGYQVL	0.8601	0.7309	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:60	LKLADFGYQV	0.8509	0.6429	7	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:16	LKLADFGYQV	0.8489	0.6923	7	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:30	LKLADFGYQV	0.8476	0.6335	7	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:67	LKLADFGYQV	0.8476	0.6335	7	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:24	LKLADFGYQV	0.8476	0.6335	7	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:11	LKLADFGYQV	0.8103	0.6586	7	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:35	LKLADFGYQV	0.7312	0.6495	7	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:29	LKLADFGYQV	0.7093	0.638	7	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:20	LKLADFGYQV	0.7082	0.6437	7	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:27	LKLADFGYQV	0.6557	0.6894	7	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:19	LKLADFGYQV	0.6428	0.6452	7	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:22	KLADFGYQVLA	0.9985	0.6587	8	19
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:24	KLADFGYQVLA	0.9983	0.698	8	19
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:67	KLADFGYQVLA	0.9983	0.698	8	19
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:30	KLADFGYQVLA	0.9983	0.698	8	19
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:60	KLADFGYQVLA	0.9983	0.6973	8	19
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B15:01	FGYQVLAPTAY	0.9968	0.9526	12	23
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B15:25	FGYQVLAPTAY	0.9848	0.9479	12	23
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B15:02	FGYQVLAPTAY	0.9713	0.9517	12	23
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B46:01	FGYQVLAPTAY	0.9576	0.7761	12	23
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:29	KLADFGYQVLA	0.8364	0.7028	8	19
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:20	KLADFGYQVLA	0.8244	0.7057	8	19
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C05:09	LADFGYQV	1	0.9948	9	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C08:15	ADFGYQVL	0.9999	0.9944	10	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C08:15	LADFGYQV	0.9998	0.9967	9	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C08:13	LADFGYQV	0.9619	0.9981	9	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C08:04	LADFGYQV	0.9619	0.9981	9	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C08:03	LADFGYQV	0.9422	0.9984	9	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C04:10	LADFGYQVL	0.9999	0.9768	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C04:07	LADFGYQVL	0.9999	0.9738	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C08:15	LADFGYQVL	0.9999	0.9955	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C05:09	LADFGYQVL	0.9999	0.9941	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C01:17	LADFGYQVL	0.9997	0.9799	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:02	KLADFGYQV	0.9995	0.6245	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:05	KLADFGYQV	0.9994	0.7068	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C03:07	LADFGYQVL	0.9994	0.9939	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:01	KLADFGYQV	0.9994	0.7521	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:07	KLADFGYQV	0.9994	0.7804	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C03:19	LADFGYQVL	0.9994	0.9969	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C03:08	LADFGYQVL	0.9988	0.9767	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C05:09	KLADFGYQV	0.9979	0.9925	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C01:30	LADFGYQVL	0.9964	0.9796	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C15:06	LADFGYQVL	0.9961	0.985	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C04:06	LADFGYQVL	0.9873	0.9899	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C08:13	LADFGYQVL	0.9829	0.997	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C08:04	LADFGYQVL	0.9829	0.997	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C04:06	KLADFGYQV	0.9727	0.9819	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B40:06	ADFGYQVLA	0.9487	0.958	10	19
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C08:03	LADFGYQVL	0.9292	0.9976	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C03:14	LADFGYQVL	0.9281	0.994	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C04:14	LADFGYQVL	0.9246	0.978	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C04:14	KLADFGYQV	0.8656	0.9616	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B35:12	LADFGYQVL	0.8506	0.9882	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C02:06	LADFGYQVL	0.7818	0.993	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B15:31	ELKLADFGY	0.7616	0.7068	6	15
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C02:06	KLADFGYQV	0.6622	0.9939	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C05:09	KLADFGYQVL	0.9997	0.9864	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:05	KLADFGYQVL	0.9983	0.5924	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C08:15	KLADFGYQVL	0.9982	0.9894	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:07	KLADFGYQVL	0.9978	0.7439	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:01	KLADFGYQVL	0.9976	0.7249	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:02	LKLADFGYQV	0.8891	0.5857	7	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:01	LKLADFGYQV	0.8476	0.6335	7	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:01	KLADFGYQVLA	0.9983	0.698	8	19
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B15:07	FGYQVLAPTAY	0.9935	0.8461	12	23
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B15:05	FGYQVLAPTAY	0.9463	0.8831	12	23
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B15:31	FGYQVLAPTAY	0.9283	0.8919	12	23
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C05:01	LADFGYQV	1	0.9948	9	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C04:03	LADFGYQV	1	0.9809	9	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C08:02	ADFGYQVL	0.9999	0.9944	10	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C08:02	LADFGYQV	0.9998	0.9967	9	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C08:01	LADFGYQV	0.9422	0.9984	9	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C01:03	LADFGYQVL	0.9999	0.9662	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C04:03	LADFGYQVL	0.9999	0.9785	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C08:02	LADFGYQVL	0.9999	0.9955	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C04:01	LADFGYQVL	0.9999	0.9738	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C05:01	LADFGYQVL	0.9999	0.9941	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C18:01	LADFGYQVL	0.9999	0.9793	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C01:02	LADFGYQVL	0.9997	0.9798	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C03:04	LADFGYQVL	0.9994	0.9959	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C03:03	LADFGYQVL	0.9994	0.9959	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:14	KLADFGYQV	0.9993	0.8241	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:06	KLADFGYQV	0.9993	0.8358	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:03	KLADFGYQV	0.9992	0.8173	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C03:17	LADFGYQVL	0.9988	0.9897	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C03:67	LADFGYQVL	0.9987	0.994	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C03:05	LADFGYQVL	0.9987	0.9697	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C05:01	KLADFGYQV	0.9979	0.9925	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C04:03	KLADFGYQV	0.9969	0.9577	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C15:05	LADFGYQVL	0.9948	0.9888	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C03:02	LADFGYQVL	0.9907	0.99	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C15:02	KLADFGYQV	0.9905	0.9633	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C15:05	KLADFGYQV	0.9883	0.9638	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C03:06	LADFGYQVL	0.988	0.9954	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C18:01	KLADFGYQV	0.9864	0.9552	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C04:04	LADFGYQVL	0.9803	0.9896	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B35:13	LADFGYQVL	0.9609	0.9766	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C16:01	LADFGYQVL	0.955	0.9919	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C08:01	LADFGYQVL	0.9292	0.9976	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B35:22	LADFGYQVL	0.9215	0.715	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C04:04	KLADFGYQV	0.9132	0.9803	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B51:05	LADFGYQVL	0.8978	0.6636	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C07:04	LADFGYQVL	0.8761	0.9837	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B35:09	LADFGYQVL	0.8506	0.9882	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A69:01	KLADFGYQV	0.8181	0.8617	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B51:06	LADFGYQVL	0.8084	0.8471	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C17:01	LADFGYQVL	0.8028	0.9895	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C17:01	KLADFGYQV	0.79	0.9778	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A32:01	KLADFGYQV	0.7335	0.9895	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B50:04	ADFGYQVLA	0.6091	0.9568	10	19
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B50:05	ADFGYQVLA	0.6091	0.9568	10	19
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B07:13	LADFGYQVL	0.3342	0.9051	9	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C07:04	KLADFGYQV	0.138	0.9665	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B40:21	KLADFGYQV	0.1271	0.7547	8	17
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C05:01	KLADFGYQVL	0.9997	0.9864	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:03	KLADFGYQVL	0.9985	0.7909	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B44:13	GELKLADFGY	0.9983	0.9407	5	15
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B44:07	GELKLADFGY	0.9983	0.9407	5	15
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B44:26	GELKLADFGY	0.9983	0.9407	5	15
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-C08:02	KLADFGYQVL	0.9982	0.9894	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-A02:14	KLADFGYQVL	0.9967	0.796	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B15:73	KLADFGYQVL	0.9932	0.987	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B15:30	KLADFGYQVL	0.9815	0.9738	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B40:21	KLADFGYQVL	0.4634	0.768	8	18
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B15:34	FGYQVLAPTAY	0.9968	0.9526	12	23
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B15:33	FGYQVLAPTAY	0.9968	0.9526	12	23
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B15:125	FGYQVLAPTAY	0.9968	0.9526	12	23
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B15:27	FGYQVLAPTAY	0.9964	0.9591	12	23
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B15:135	FGYQVLAPTAY	0.9959	0.969	12	23
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B15:50	FGYQVLAPTAY	0.9945	0.9491	12	23
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B15:35	FGYQVLAPTAY	0.9928	0.9641	12	23
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B15:12	FGYQVLAPTAY	0.9871	0.9616	12	23
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B15:39	FGYQVLAPTAY	0.9847	0.925	12	23
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B15:20	FGYQVLAPTAY	0.9514	0.8983	12	23
CDK14-PUM2	chr7	90547039	chr2	20483247	916	HLA-B35:28	FGYQVLAPTAY	0.9321	0.9006	12	23

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Potential FusionNeoAntigen Information of CDK14-PUM2 in HLA II

CDK14-PUM2_90547039_20483247.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
CDK14-PUM2	chr7	90547039	chr2	20483247	916	DRB1-1216	DFGYQVLAPTAYYDQ	11	26
CDK14-PUM2	chr7	90547039	chr2	20483247	916	DRB1-1216	ADFGYQVLAPTAYYD	10	25
CDK14-PUM2	chr7	90547039	chr2	20483247	916	DRB1-1222	DFGYQVLAPTAYYDQ	11	26
CDK14-PUM2	chr7	90547039	chr2	20483247	916	DRB1-1222	ADFGYQVLAPTAYYD	10	25
CDK14-PUM2	chr7	90547039	chr2	20483247	916	DRB1-1222	LADFGYQVLAPTAYY	9	24

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Fusion breakpoint peptide structures of CDK14-PUM2

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
1907	ELKLADFGYQVLAP	CDK14	PUM2	chr7	90547039	chr2	20483247	916

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of CDK14-PUM2

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	1907	ELKLADFGYQVLAP	-7.15543	-7.26883
HLA-B14:02	3BVN	1907	ELKLADFGYQVLAP	-4.77435	-5.80965
HLA-B52:01	3W39	1907	ELKLADFGYQVLAP	-6.80875	-6.92215
HLA-B52:01	3W39	1907	ELKLADFGYQVLAP	-4.20386	-5.23916
HLA-A11:01	4UQ2	1907	ELKLADFGYQVLAP	-7.5194	-8.5547
HLA-A11:01	4UQ2	1907	ELKLADFGYQVLAP	-6.9601	-7.0735
HLA-A24:02	5HGA	1907	ELKLADFGYQVLAP	-7.52403	-7.63743
HLA-A24:02	5HGA	1907	ELKLADFGYQVLAP	-5.82433	-6.85963
HLA-B27:05	6PYJ	1907	ELKLADFGYQVLAP	-3.28285	-4.31815
HLA-B44:05	3DX8	1907	ELKLADFGYQVLAP	-5.91172	-6.94702
HLA-B44:05	3DX8	1907	ELKLADFGYQVLAP	-4.24346	-4.35686

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Vaccine Design for the FusionNeoAntigens of CDK14-PUM2

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
CDK14-PUM2	chr7	90547039	chr2	20483247	10	18	ADFGYQVL	CAGATTTCGGCTATCAAGTACTAG
CDK14-PUM2	chr7	90547039	chr2	20483247	10	19	ADFGYQVLA	CAGATTTCGGCTATCAAGTACTAGCTC
CDK14-PUM2	chr7	90547039	chr2	20483247	12	23	FGYQVLAPTAY	TCGGCTATCAAGTACTAGCTCCAACTGCCTATT
CDK14-PUM2	chr7	90547039	chr2	20483247	5	15	GELKLADFGY	GGGAGTTAAAGCTGGCAGATTTCGGCTATC
CDK14-PUM2	chr7	90547039	chr2	20483247	6	15	ELKLADFGY	AGTTAAAGCTGGCAGATTTCGGCTATC
CDK14-PUM2	chr7	90547039	chr2	20483247	7	17	LKLADFGYQV	TAAAGCTGGCAGATTTCGGCTATCAAGTAC
CDK14-PUM2	chr7	90547039	chr2	20483247	8	17	KLADFGYQV	AGCTGGCAGATTTCGGCTATCAAGTAC
CDK14-PUM2	chr7	90547039	chr2	20483247	8	18	KLADFGYQVL	AGCTGGCAGATTTCGGCTATCAAGTACTAG
CDK14-PUM2	chr7	90547039	chr2	20483247	8	19	KLADFGYQVLA	AGCTGGCAGATTTCGGCTATCAAGTACTAGCTC
CDK14-PUM2	chr7	90547039	chr2	20483247	9	17	LADFGYQV	TGGCAGATTTCGGCTATCAAGTAC
CDK14-PUM2	chr7	90547039	chr2	20483247	9	18	LADFGYQVL	TGGCAGATTTCGGCTATCAAGTACTAG

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
CDK14-PUM2	chr7	90547039	chr2	20483247	10	25	ADFGYQVLAPTAYYD	CAGATTTCGGCTATCAAGTACTAGCTCCAACTGCCTATTATGATC
CDK14-PUM2	chr7	90547039	chr2	20483247	11	26	DFGYQVLAPTAYYDQ	ATTTCGGCTATCAAGTACTAGCTCCAACTGCCTATTATGATCAGA
CDK14-PUM2	chr7	90547039	chr2	20483247	9	24	LADFGYQVLAPTAYY	TGGCAGATTTCGGCTATCAAGTACTAGCTCCAACTGCCTATTATG

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Information of the samples that have these potential fusion neoantigens of CDK14-PUM2

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
STAD	CDK14-PUM2	chr7	90547039	ENST00000265741	chr2	20483247	ENST00000319801	TCGA-CD-A486-01A

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Potential target of CAR-T therapy development for CDK14-PUM2

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to CDK14-PUM2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CDK14-PUM2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)