|
|||||||
|
Fusion Protein:CEACAM1-ABCC11 |
Fusion Gene and Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: CEACAM1-ABCC11 | FusionPDB ID: 15504 | FusionGDB2.0 ID: 15504 | Hgene | Tgene | Gene symbol | CEACAM1 | ABCC11 | Gene ID | 634 | 85320 |
| Gene name | CEA cell adhesion molecule 1 | ATP binding cassette subfamily C member 11 | |
| Synonyms | BGP|BGP1|BGPI | EWWD|MRP8|WW | |
| Cytomap | 19q13.2 | 16q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | carcinoembryonic antigen-related cell adhesion molecule 1CD66a antigenantigen CD66carcinoembryonic antigen related cell adhesion molecule 1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | ATP-binding cassette sub-family C member 11ATP-binding cassette protein C11ATP-binding cassette transporter MRP8ATP-binding cassette transporter sub-family C member 11ATP-binding cassette, sub-family C (CFTR/MRP), member 11multi-resistance protein 8 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P13688 Main function of 5'-partner protein: FUNCTION: [Isoform 1]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763). Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed:18424730, PubMed:23696226). Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730). Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2 (PubMed:25363763). Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (PubMed:23696226). Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4-CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Downregulates neutrophil production by acting as a coinhibitory receptor for CSF3R by downregulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity). Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis. This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis. INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways (By similarity). Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production (By similarity). Downregulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity). Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex (By similarity). Inhibits cell migration and cell scattering through interaction with FLNA; interfers with the interaction of FLNA with RALA (PubMed:16291724). Mediates bile acid transport activity in a phosphorylation dependent manner (By similarity). Negatively regulates osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P16573, ECO:0000250|UniProtKB:P31809, ECO:0000269|PubMed:16291724, ECO:0000269|PubMed:18424730, ECO:0000269|PubMed:23696226, ECO:0000269|PubMed:25363763}.; FUNCTION: [Isoform 8]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens (By similarity). {ECO:0000250|UniProtKB:P16573, ECO:0000250|UniProtKB:P31809}. | Q96J66 Main function of 5'-partner protein: FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides (PubMed:12764137, PubMed:15537867). Stimulates the ATP-dependent uptake of a range of physiological lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate (PubMed:15537867, PubMed:25896536). Enhances also the cellular extrusion of cAMP and cGMP (PubMed:12764137, PubMed:15537867). Confers resistance to anticancer drugs, such as 5-fluorouracil (5-FU) and methotrexate (PubMed:25896536, PubMed:15537867, PubMed:12764137). Probably functions to secrete earwax (PubMed:16444273, PubMed:19383836). Required for the secretion of components contributing to axillary odor formation (PubMed:19710689, PubMed:12764137, PubMed:15537867, PubMed:16444273, PubMed:19383836, PubMed:25896536). {ECO:0000269|PubMed:12764137, ECO:0000269|PubMed:15537867, ECO:0000269|PubMed:16444273, ECO:0000269|PubMed:19383836, ECO:0000269|PubMed:19710689, ECO:0000269|PubMed:25896536}. | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000161559, ENST00000308072, ENST00000352591, ENST00000358394, ENST00000403444, ENST00000403461, ENST00000599389, ENST00000351134, ENST00000488639, | ENST00000565329, ENST00000353782, ENST00000356608, ENST00000394747, ENST00000394748, ENST00000537808, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 1 X 1 X 1=1 | 6 X 5 X 3=90 |
| # samples | 1 | 7 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Fusion gene context | PubMed: CEACAM1 [Title/Abstract] AND ABCC11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Fusion neoantigen context | PubMed: CEACAM1 [Title/Abstract] AND ABCC11 [Title/Abstract] AND neoantigen [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CEACAM1(43025419)-ABCC11(48230232), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | CEACAM1-ABCC11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CEACAM1-ABCC11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CEACAM1-ABCC11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CEACAM1-ABCC11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CEACAM1-ABCC11 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. CEACAM1-ABCC11 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CEACAM1 | GO:0001915 | negative regulation of T cell mediated cytotoxicity | 18424730 |
| Hgene | CEACAM1 | GO:0030334 | regulation of cell migration | 16291724 |
| Hgene | CEACAM1 | GO:0043318 | negative regulation of cytotoxic T cell degranulation | 18424730 |
| Hgene | CEACAM1 | GO:0044319 | wound healing, spreading of cells | 16291724 |
| Hgene | CEACAM1 | GO:0050860 | negative regulation of T cell receptor signaling pathway | 18424730 |
| Tgene | ABCC11 | GO:0015711 | organic anion transport | 15537867|16359813 |
| Tgene | ABCC11 | GO:0015865 | purine nucleotide transport | 12764137 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:43025419/chr16:48230232) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here. |
| Fusion gene breakpoints across CEACAM1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across ABCC11 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Fusion Amino Acid Sequences |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000352591 | CEACAM1 | chr19 | 43025419 | - | ENST00000353782 | ABCC11 | chr16 | 48230232 | - | 3115 | 1030 | 72 | 2750 | 892 |
| ENST00000352591 | CEACAM1 | chr19 | 43025419 | - | ENST00000356608 | ABCC11 | chr16 | 48230232 | - | 3229 | 1030 | 72 | 2864 | 930 |
| ENST00000352591 | CEACAM1 | chr19 | 43025419 | - | ENST00000394747 | ABCC11 | chr16 | 48230232 | - | 3228 | 1030 | 72 | 2864 | 930 |
| ENST00000352591 | CEACAM1 | chr19 | 43025419 | - | ENST00000394748 | ABCC11 | chr16 | 48230232 | - | 3228 | 1030 | 72 | 2864 | 930 |
| ENST00000352591 | CEACAM1 | chr19 | 43025419 | - | ENST00000537808 | ABCC11 | chr16 | 48230232 | - | 1650 | 1030 | 72 | 1649 | 526 |
| ENST00000161559 | CEACAM1 | chr19 | 43025419 | - | ENST00000353782 | ABCC11 | chr16 | 48230232 | - | 3178 | 1093 | 6 | 2813 | 935 |
| ENST00000161559 | CEACAM1 | chr19 | 43025419 | - | ENST00000356608 | ABCC11 | chr16 | 48230232 | - | 3292 | 1093 | 6 | 2927 | 973 |
| ENST00000161559 | CEACAM1 | chr19 | 43025419 | - | ENST00000394747 | ABCC11 | chr16 | 48230232 | - | 3291 | 1093 | 6 | 2927 | 973 |
| ENST00000161559 | CEACAM1 | chr19 | 43025419 | - | ENST00000394748 | ABCC11 | chr16 | 48230232 | - | 3291 | 1093 | 6 | 2927 | 973 |
| ENST00000161559 | CEACAM1 | chr19 | 43025419 | - | ENST00000537808 | ABCC11 | chr16 | 48230232 | - | 1713 | 1093 | 6 | 1712 | 569 |
| ENST00000403444 | CEACAM1 | chr19 | 43025419 | - | ENST00000353782 | ABCC11 | chr16 | 48230232 | - | 3147 | 1062 | 104 | 2782 | 892 |
| ENST00000403444 | CEACAM1 | chr19 | 43025419 | - | ENST00000356608 | ABCC11 | chr16 | 48230232 | - | 3261 | 1062 | 104 | 2896 | 930 |
| ENST00000403444 | CEACAM1 | chr19 | 43025419 | - | ENST00000394747 | ABCC11 | chr16 | 48230232 | - | 3260 | 1062 | 104 | 2896 | 930 |
| ENST00000403444 | CEACAM1 | chr19 | 43025419 | - | ENST00000394748 | ABCC11 | chr16 | 48230232 | - | 3260 | 1062 | 104 | 2896 | 930 |
| ENST00000403444 | CEACAM1 | chr19 | 43025419 | - | ENST00000537808 | ABCC11 | chr16 | 48230232 | - | 1682 | 1062 | 104 | 1681 | 526 |
| ENST00000403461 | CEACAM1 | chr19 | 43025419 | - | ENST00000353782 | ABCC11 | chr16 | 48230232 | - | 3049 | 964 | 6 | 2684 | 892 |
| ENST00000403461 | CEACAM1 | chr19 | 43025419 | - | ENST00000356608 | ABCC11 | chr16 | 48230232 | - | 3163 | 964 | 6 | 2798 | 930 |
| ENST00000403461 | CEACAM1 | chr19 | 43025419 | - | ENST00000394747 | ABCC11 | chr16 | 48230232 | - | 3162 | 964 | 6 | 2798 | 930 |
| ENST00000403461 | CEACAM1 | chr19 | 43025419 | - | ENST00000394748 | ABCC11 | chr16 | 48230232 | - | 3162 | 964 | 6 | 2798 | 930 |
| ENST00000403461 | CEACAM1 | chr19 | 43025419 | - | ENST00000537808 | ABCC11 | chr16 | 48230232 | - | 1584 | 964 | 6 | 1583 | 526 |
| ENST00000358394 | CEACAM1 | chr19 | 43025419 | - | ENST00000353782 | ABCC11 | chr16 | 48230232 | - | 3135 | 1050 | 92 | 2770 | 892 |
| ENST00000358394 | CEACAM1 | chr19 | 43025419 | - | ENST00000356608 | ABCC11 | chr16 | 48230232 | - | 3249 | 1050 | 92 | 2884 | 930 |
| ENST00000358394 | CEACAM1 | chr19 | 43025419 | - | ENST00000394747 | ABCC11 | chr16 | 48230232 | - | 3248 | 1050 | 92 | 2884 | 930 |
| ENST00000358394 | CEACAM1 | chr19 | 43025419 | - | ENST00000394748 | ABCC11 | chr16 | 48230232 | - | 3248 | 1050 | 92 | 2884 | 930 |
| ENST00000358394 | CEACAM1 | chr19 | 43025419 | - | ENST00000537808 | ABCC11 | chr16 | 48230232 | - | 1670 | 1050 | 92 | 1669 | 526 |
| ENST00000599389 | CEACAM1 | chr19 | 43025419 | - | ENST00000353782 | ABCC11 | chr16 | 48230232 | - | 3150 | 1065 | 107 | 2785 | 892 |
| ENST00000599389 | CEACAM1 | chr19 | 43025419 | - | ENST00000356608 | ABCC11 | chr16 | 48230232 | - | 3264 | 1065 | 107 | 2899 | 930 |
| ENST00000599389 | CEACAM1 | chr19 | 43025419 | - | ENST00000394747 | ABCC11 | chr16 | 48230232 | - | 3263 | 1065 | 107 | 2899 | 930 |
| ENST00000599389 | CEACAM1 | chr19 | 43025419 | - | ENST00000394748 | ABCC11 | chr16 | 48230232 | - | 3263 | 1065 | 107 | 2899 | 930 |
| ENST00000599389 | CEACAM1 | chr19 | 43025419 | - | ENST00000537808 | ABCC11 | chr16 | 48230232 | - | 1685 | 1065 | 107 | 1684 | 526 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000352591 | ENST00000353782 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.001695078 | 0.99830496 |
| ENST00000352591 | ENST00000356608 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.001156982 | 0.99884295 |
| ENST00000352591 | ENST00000394747 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.001147506 | 0.9988525 |
| ENST00000352591 | ENST00000394748 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.001147506 | 0.9988525 |
| ENST00000352591 | ENST00000537808 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.47612858 | 0.5238714 |
| ENST00000161559 | ENST00000353782 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.001760125 | 0.9982399 |
| ENST00000161559 | ENST00000356608 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.00119156 | 0.9988085 |
| ENST00000161559 | ENST00000394747 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.0011843 | 0.9988158 |
| ENST00000161559 | ENST00000394748 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.0011843 | 0.9988158 |
| ENST00000161559 | ENST00000537808 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.61323285 | 0.38676715 |
| ENST00000403444 | ENST00000353782 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.001682529 | 0.9983175 |
| ENST00000403444 | ENST00000356608 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.001143103 | 0.9988569 |
| ENST00000403444 | ENST00000394747 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.001135452 | 0.99886453 |
| ENST00000403444 | ENST00000394748 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.001135452 | 0.99886453 |
| ENST00000403444 | ENST00000537808 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.2624364 | 0.7375636 |
| ENST00000403461 | ENST00000353782 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.001634184 | 0.9983658 |
| ENST00000403461 | ENST00000356608 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.001119809 | 0.9988802 |
| ENST00000403461 | ENST00000394747 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.001112211 | 0.99888784 |
| ENST00000403461 | ENST00000394748 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.001112211 | 0.99888784 |
| ENST00000403461 | ENST00000537808 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.6633538 | 0.33664614 |
| ENST00000358394 | ENST00000353782 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.001757971 | 0.998242 |
| ENST00000358394 | ENST00000356608 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.001192332 | 0.99880767 |
| ENST00000358394 | ENST00000394747 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.001184325 | 0.99881566 |
| ENST00000358394 | ENST00000394748 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.001184325 | 0.99881566 |
| ENST00000358394 | ENST00000537808 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.26161617 | 0.7383838 |
| ENST00000599389 | ENST00000353782 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.001736969 | 0.99826306 |
| ENST00000599389 | ENST00000356608 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.001174724 | 0.99882525 |
| ENST00000599389 | ENST00000394747 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.001167273 | 0.99883276 |
| ENST00000599389 | ENST00000394748 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.001167273 | 0.99883276 |
| ENST00000599389 | ENST00000537808 | CEACAM1 | chr19 | 43025419 | - | ABCC11 | chr16 | 48230232 | - | 0.3192135 | 0.68078655 |
| Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones. |
Get the fusion protein sequences from here. |
| Fusion protein sequence information is available in the fasta format. >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP |
Top |
Fusion Protein Breakpoint Sequences for CEACAM1-ABCC11 |
| +/-13 AA sequence from the breakpoints of the fusion protein sequences. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Length(fusion protein) | BP in fusion protein | Peptide |
| CEACAM1 | chr19 | 43025419 | ABCC11 | chr16 | 48230232 | 1030 | 319 | GCNRTTVKTIIVTVPEHQLTQEEEME |
| CEACAM1 | chr19 | 43025419 | ABCC11 | chr16 | 48230232 | 1050 | 319 | GCNRTTVKTIIVTVPEHQLTQEEEME |
| CEACAM1 | chr19 | 43025419 | ABCC11 | chr16 | 48230232 | 1062 | 319 | GCNRTTVKTIIVTVPEHQLTQEEEME |
| CEACAM1 | chr19 | 43025419 | ABCC11 | chr16 | 48230232 | 1065 | 319 | GCNRTTVKTIIVTVPEHQLTQEEEME |
| CEACAM1 | chr19 | 43025419 | ABCC11 | chr16 | 48230232 | 1093 | 362 | GCNRTTVKTIIVTVPEHQLTQEEEME |
| CEACAM1 | chr19 | 43025419 | ABCC11 | chr16 | 48230232 | 964 | 319 | GCNRTTVKTIIVTVPEHQLTQEEEME |
Top |
Potential FusionNeoAntigen Information of CEACAM1-ABCC11 in HLA I |
| Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific. |
| CEACAM1-ABCC11_43025419_48230232.msa |
| Potential FusionNeoAntigen Information * We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5) |
| Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA I | FusionNeoAntigen peptide | Binding score | Immunogenic score | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-A30:08 | TVKTIIVTV | 0.9933 | 0.664 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-A02:38 | TVKTIIVTV | 0.9418 | 0.5301 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-A02:13 | TVKTIIVTV | 0.9317 | 0.6126 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-A02:35 | TVKTIIVTV | 0.9025 | 0.5136 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-A02:21 | TVKTIIVTV | 0.8887 | 0.6321 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-A02:04 | TVKTIIVTV | 0.865 | 0.5733 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-A02:11 | TVKTIIVTV | 0.8286 | 0.5274 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-B13:02 | TVKTIIVTV | 0.7059 | 0.799 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-B52:01 | TVKTIIVTV | 0.5853 | 0.9389 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C03:08 | VTVPEHQL | 0.9997 | 0.9039 | 11 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C15:06 | VTVPEHQL | 0.9997 | 0.914 | 11 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C03:07 | VTVPEHQL | 0.9997 | 0.9848 | 11 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C12:04 | TVKTIIVTV | 0.9981 | 0.9927 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C06:03 | TVKTIIVTV | 0.9977 | 0.9929 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C15:06 | TVKTIIVTV | 0.9973 | 0.9406 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C03:07 | IVTVPEHQL | 0.9957 | 0.9764 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C12:12 | TVKTIIVTV | 0.9956 | 0.9354 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C03:08 | IVTVPEHQL | 0.9951 | 0.8334 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C03:19 | IVTVPEHQL | 0.9912 | 0.9763 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C15:06 | IVTVPEHQL | 0.9841 | 0.9209 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C04:06 | IVTVPEHQL | 0.9584 | 0.9509 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C02:06 | TVKTIIVTV | 0.9407 | 0.9813 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C01:17 | IVTVPEHQL | 0.9051 | 0.9199 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C08:04 | IVTVPEHQL | 0.8101 | 0.9781 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C08:13 | IVTVPEHQL | 0.8101 | 0.9781 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-B78:01 | TVKTIIVTV | 0.7882 | 0.5878 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-B51:07 | TVKTIIVTV | 0.5331 | 0.7972 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C02:06 | IVTVPEHQL | 0.526 | 0.9148 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C08:03 | IVTVPEHQL | 0.4221 | 0.9872 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C01:30 | IVTVPEHQL | 0.4168 | 0.9476 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C03:17 | VTVPEHQL | 0.9998 | 0.9666 | 11 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C15:05 | VTVPEHQL | 0.9996 | 0.9129 | 11 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C15:02 | TVKTIIVTV | 0.9979 | 0.9104 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C15:05 | TVKTIIVTV | 0.9969 | 0.9137 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C03:03 | IVTVPEHQL | 0.9962 | 0.9811 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C03:04 | IVTVPEHQL | 0.9962 | 0.9811 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-A30:01 | TVKTIIVTV | 0.9939 | 0.8439 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C03:05 | IVTVPEHQL | 0.9927 | 0.9097 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C03:17 | IVTVPEHQL | 0.9902 | 0.9626 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C15:05 | IVTVPEHQL | 0.9833 | 0.9308 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-A02:03 | TVKTIIVTV | 0.9831 | 0.5708 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C12:03 | TVKTIIVTV | 0.9818 | 0.9781 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C15:02 | IVTVPEHQL | 0.9811 | 0.8936 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-A69:01 | TVKTIIVTV | 0.9786 | 0.6588 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C01:02 | IVTVPEHQL | 0.9279 | 0.9161 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C03:06 | IVTVPEHQL | 0.9209 | 0.9809 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C01:03 | IVTVPEHQL | 0.9042 | 0.9397 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-A02:06 | TVKTIIVTV | 0.8887 | 0.6321 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C02:02 | TVKTIIVTV | 0.8611 | 0.984 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C02:10 | TVKTIIVTV | 0.8611 | 0.984 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C16:02 | IVTVPEHQL | 0.8482 | 0.9931 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-B35:13 | IVTVPEHQL | 0.7003 | 0.7936 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-A25:01 | TVKTIIVTV | 0.476 | 0.7081 | 5 | 14 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C08:01 | IVTVPEHQL | 0.4221 | 0.9872 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-C17:01 | IVTVPEHQL | 0.41 | 0.9051 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-B07:13 | IVTVPEHQL | 0.27 | 0.7576 | 10 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | HLA-A69:01 | TTVKTIIVTV | 0.9943 | 0.6215 | 4 | 14 |
Top |
Potential FusionNeoAntigen Information of CEACAM1-ABCC11 in HLA II |
| Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific. |
| CEACAM1-ABCC11_43025419_48230232.msa |
| Potential FusionNeoAntigen Information * We used NetMHCIIpan v4.1 (%rank<0.5). |
| Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA II | FusionNeoAntigen peptide | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-0807 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-0807 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-0810 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-0810 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-0812 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-0812 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-0819 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-0819 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-0825 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-0825 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-0832 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-0832 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-0834 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-0834 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-0906 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-0906 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1201 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1201 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1203 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1203 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1203 | TVKTIIVTVPEHQLT | 5 | 20 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1204 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1204 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1205 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1205 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1206 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1206 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1207 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1207 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1208 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1208 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1208 | TVKTIIVTVPEHQLT | 5 | 20 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1209 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1209 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1210 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1210 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1211 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1211 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1212 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1212 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1213 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1213 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1214 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1214 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1215 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1215 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1216 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1216 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1217 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1217 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1218 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1218 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1219 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1219 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1220 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1220 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1220 | TVKTIIVTVPEHQLT | 5 | 20 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1221 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1221 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1221 | TVKTIIVTVPEHQLT | 5 | 20 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1222 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1222 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1223 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1223 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1331 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1343 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1354 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1377 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1377 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1404 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1404 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1410 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1416 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1428 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1428 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1431 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1431 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1432 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1439 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1439 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1439 | TVKTIIVTVPEHQLT | 5 | 20 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1448 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1450 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1452 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1455 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1455 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1457 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1461 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1461 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1470 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1470 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1471 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1471 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1501 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1503 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1503 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1503 | TIIVTVPEHQLTQEE | 8 | 23 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1503 | TVKTIIVTVPEHQLT | 5 | 20 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1503 | TTVKTIIVTVPEHQL | 4 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1504 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1504 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1505 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1506 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1507 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1507 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1509 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1510 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1510 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1512 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1512 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1513 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1516 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1518 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1520 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1521 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1521 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1522 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1523 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1523 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1523 | TVKTIIVTVPEHQLT | 5 | 20 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1523 | TIIVTVPEHQLTQEE | 8 | 23 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1523 | TTVKTIIVTVPEHQL | 4 | 19 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1524 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1525 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1525 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1528 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1528 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1529 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1532 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1533 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1535 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1536 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1540 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1541 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1542 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1543 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1545 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1546 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1548 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1548 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1549 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1615 | KTIIVTVPEHQLTQE | 7 | 22 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB1-1615 | VKTIIVTVPEHQLTQ | 6 | 21 |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 | DRB5-0205 | KTIIVTVPEHQLTQE | 7 | 22 |
Top |
Fusion breakpoint peptide structures of CEACAM1-ABCC11 |
| 3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens * The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA. |
| File name | BPseq | Hgene | Tgene | Hchr | Hbp | Tchr | Tbp | AAlen |
| 10058 | VKTIIVTVPEHQLT | CEACAM1 | ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 1093 |
Top |
Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of CEACAM1-ABCC11 |
| Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens * We used Glide to predict the interaction between HLAs and neoantigens. |
| HLA allele | PDB ID | File name | BPseq | Docking score | Glide score |
| HLA-B14:02 | 3BVN | 10058 | VKTIIVTVPEHQLT | -7.15543 | -7.26883 |
| HLA-B14:02 | 3BVN | 10058 | VKTIIVTVPEHQLT | -4.77435 | -5.80965 |
| HLA-B52:01 | 3W39 | 10058 | VKTIIVTVPEHQLT | -6.80875 | -6.92215 |
| HLA-B52:01 | 3W39 | 10058 | VKTIIVTVPEHQLT | -4.20386 | -5.23916 |
| HLA-A11:01 | 4UQ2 | 10058 | VKTIIVTVPEHQLT | -7.5194 | -8.5547 |
| HLA-A11:01 | 4UQ2 | 10058 | VKTIIVTVPEHQLT | -6.9601 | -7.0735 |
| HLA-A24:02 | 5HGA | 10058 | VKTIIVTVPEHQLT | -7.52403 | -7.63743 |
| HLA-A24:02 | 5HGA | 10058 | VKTIIVTVPEHQLT | -5.82433 | -6.85963 |
| HLA-B27:05 | 6PYJ | 10058 | VKTIIVTVPEHQLT | -3.28285 | -4.31815 |
| HLA-B44:05 | 3DX8 | 10058 | VKTIIVTVPEHQLT | -5.91172 | -6.94702 |
| HLA-B44:05 | 3DX8 | 10058 | VKTIIVTVPEHQLT | -4.24346 | -4.35686 |
| HLA-B35:01 | 1A1N | 10058 | VKTIIVTVPEHQLT | -5.9251 | -6.0385 |
| HLA-B35:01 | 1A1N | 10058 | VKTIIVTVPEHQLT | -4.80237 | -5.83767 |
Top |
Vaccine Design for the FusionNeoAntigens of CEACAM1-ABCC11 |
| mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is. |
| Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide sequence | FusionNeoAntigen RNA sequence |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 10 | 19 | IVTVPEHQL | TAGTCACTGTGCCGGAGCATCAGCTCA |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 11 | 19 | VTVPEHQL | TCACTGTGCCGGAGCATCAGCTCA |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 4 | 14 | TTVKTIIVTV | CCACAGTCAAGACGATCATAGTCACTGTGC |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 5 | 14 | TVKTIIVTV | CAGTCAAGACGATCATAGTCACTGTGC |
| mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs. |
| Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide | FusionNEoAntigen RNA sequence |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 4 | 19 | TTVKTIIVTVPEHQL | CCACAGTCAAGACGATCATAGTCACTGTGCCGGAGCATCAGCTCA |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 5 | 20 | TVKTIIVTVPEHQLT | CAGTCAAGACGATCATAGTCACTGTGCCGGAGCATCAGCTCACAC |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 6 | 21 | VKTIIVTVPEHQLTQ | TCAAGACGATCATAGTCACTGTGCCGGAGCATCAGCTCACACAGG |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 7 | 22 | KTIIVTVPEHQLTQE | AGACGATCATAGTCACTGTGCCGGAGCATCAGCTCACACAGGAGG |
| CEACAM1-ABCC11 | chr19 | 43025419 | chr16 | 48230232 | 8 | 23 | TIIVTVPEHQLTQEE | CGATCATAGTCACTGTGCCGGAGCATCAGCTCACACAGGAGGAGG |
Top |
Information of the samples that have these potential fusion neoantigens of CEACAM1-ABCC11 |
| These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens. |
| Cancer type | Fusion gene | Hchr | Hbp | Henst | Tchr | Tbp | Tenst | Sample |
| BRCA | CEACAM1-ABCC11 | chr19 | 43025419 | ENST00000161559 | chr16 | 48230232 | ENST00000353782 | TCGA-BH-A0DE-01A |
Top |
Potential target of CAR-T therapy development for CEACAM1-ABCC11 |
| Predicted 3D structure. We used RoseTTAFold. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features * Minus value of BPloci means that the break point is located before the CDS. |
| - In-frame and retained 'Transmembrane'. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CEACAM1 | chr19:43025419 | chr16:48230232 | ENST00000403461 | - | 4 | 7 | 429_452 | 319 | 282.0 | Transmembrane | Helical |
| Hgene | CEACAM1 | chr19:43025419 | chr16:48230232 | ENST00000599389 | - | 4 | 8 | 429_452 | 319 | 241.0 | Transmembrane | Helical |
| Tgene | ABCC11 | chr19:43025419 | chr16:48230232 | ENST00000353782 | 16 | 29 | 1050_1070 | 0 | 1345.0 | Transmembrane | Helical | |
| Tgene | ABCC11 | chr19:43025419 | chr16:48230232 | ENST00000353782 | 16 | 29 | 807_827 | 0 | 1345.0 | Transmembrane | Helical | |
| Tgene | ABCC11 | chr19:43025419 | chr16:48230232 | ENST00000353782 | 16 | 29 | 864_884 | 0 | 1345.0 | Transmembrane | Helical | |
| Tgene | ABCC11 | chr19:43025419 | chr16:48230232 | ENST00000353782 | 16 | 29 | 931_951 | 0 | 1345.0 | Transmembrane | Helical | |
| Tgene | ABCC11 | chr19:43025419 | chr16:48230232 | ENST00000356608 | 16 | 30 | 1050_1070 | 0 | 1383.0 | Transmembrane | Helical | |
| Tgene | ABCC11 | chr19:43025419 | chr16:48230232 | ENST00000356608 | 16 | 30 | 807_827 | 0 | 1383.0 | Transmembrane | Helical | |
| Tgene | ABCC11 | chr19:43025419 | chr16:48230232 | ENST00000356608 | 16 | 30 | 864_884 | 0 | 1383.0 | Transmembrane | Helical | |
| Tgene | ABCC11 | chr19:43025419 | chr16:48230232 | ENST00000356608 | 16 | 30 | 931_951 | 0 | 1383.0 | Transmembrane | Helical | |
| Tgene | ABCC11 | chr19:43025419 | chr16:48230232 | ENST00000394747 | 15 | 29 | 1050_1070 | 0 | 1383.0 | Transmembrane | Helical | |
| Tgene | ABCC11 | chr19:43025419 | chr16:48230232 | ENST00000394747 | 15 | 29 | 807_827 | 0 | 1383.0 | Transmembrane | Helical | |
| Tgene | ABCC11 | chr19:43025419 | chr16:48230232 | ENST00000394747 | 15 | 29 | 864_884 | 0 | 1383.0 | Transmembrane | Helical | |
| Tgene | ABCC11 | chr19:43025419 | chr16:48230232 | ENST00000394747 | 15 | 29 | 931_951 | 0 | 1383.0 | Transmembrane | Helical | |
| Tgene | ABCC11 | chr19:43025419 | chr16:48230232 | ENST00000394748 | 16 | 30 | 1050_1070 | 0 | 1383.0 | Transmembrane | Helical | |
| Tgene | ABCC11 | chr19:43025419 | chr16:48230232 | ENST00000394748 | 16 | 30 | 807_827 | 0 | 1383.0 | Transmembrane | Helical | |
| Tgene | ABCC11 | chr19:43025419 | chr16:48230232 | ENST00000394748 | 16 | 30 | 864_884 | 0 | 1383.0 | Transmembrane | Helical | |
| Tgene | ABCC11 | chr19:43025419 | chr16:48230232 | ENST00000394748 | 16 | 30 | 931_951 | 0 | 1383.0 | Transmembrane | Helical |
| Subcellular localization prediction of the transmembrane domain retained fusion proteins * We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image. |
| Hgene | Hchr | Hbp | Henst | Tgene | Tchr | Tbp | Tenst | DeepLoc result |
| CEACAM1 | chr19 | 43025419 | ENST00000161559 | ABCC11 | chr16 | 48230232 | ENST00000353782 |  |
| CEACAM1 | chr19 | 43025419 | ENST00000161559 | ABCC11 | chr16 | 48230232 | ENST00000356608 |  |
| CEACAM1 | chr19 | 43025419 | ENST00000161559 | ABCC11 | chr16 | 48230232 | ENST00000537808 |  |
| CEACAM1 | chr19 | 43025419 | ENST00000352591 | ABCC11 | chr16 | 48230232 | ENST00000353782 |  |
| CEACAM1 | chr19 | 43025419 | ENST00000352591 | ABCC11 | chr16 | 48230232 | ENST00000356608 |  |
| CEACAM1 | chr19 | 43025419 | ENST00000352591 | ABCC11 | chr16 | 48230232 | ENST00000537808 |  |
Top |
Related Drugs to CEACAM1-ABCC11 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to CEACAM1-ABCC11 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2023-PresentThe University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information
Campus Carry|Site Policies