FusionNeoAntigen Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine
leaf

Fusion Gene and Fusion Protein Summary

leaf

Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

leaf

Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

leaf

Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

leaf

Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

leaf

Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

leaf

Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

leaf

Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

leaf

Potential target of CAR-T therapy development

leaf

Information on the samples that have these potential fusion neoantigens

leaf

Fusion Protein Targeting Drugs - (Manual Curation)

leaf

Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:CERS6-NOSTRIN

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CERS6-NOSTRIN
FusionPDB ID: 16003
FusionGDB2.0 ID: 16003
HgeneTgene
Gene symbol

CERS6

NOSTRIN

Gene ID

253782

115677

Gene nameceramide synthase 6nitric oxide synthase trafficking
SynonymsCERS5|LASS6DaIP2
Cytomap

2q24.3

2q24.3

Type of geneprotein-codingprotein-coding
Descriptionceramide synthase 6LAG1 homolog, ceramide synthase 6longevity assurance homolog 6nostrinBM247 homologENOS traffic inducereNOS-trafficking inducerendothelial nitric oxide synthase traffic inducernitric oxide synthase traffic inducernitric oxide synthase traffickerortholog of mouse disabled 2 interacting proein 2
Modification date2020031320200313
UniProtAcc

Q6ZMG9

Main function of 5'-partner protein: FUNCTION: Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) as acyl donor (PubMed:17977534, PubMed:17609214, PubMed:23530041, PubMed:26887952, PubMed:31916624). Can use other acyl donors, but with less efficiency (By similarity). Ceramides generated by CERS6 play a role in inflammatory response (By similarity). Acts as a regulator of metabolism and hepatic lipid accumulation (By similarity). Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (By similarity). {ECO:0000250|UniProtKB:Q8C172, ECO:0000269|PubMed:17609214, ECO:0000269|PubMed:17977534, ECO:0000269|PubMed:23530041, ECO:0000269|PubMed:26887952, ECO:0000269|PubMed:31916624}.

Q8IVI9

Main function of 5'-partner protein: FUNCTION: Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. {ECO:0000269|PubMed:12446846, ECO:0000269|PubMed:16234328, ECO:0000269|PubMed:16807357}.
Ensembl transtripts involved in fusion geneENST idsENST00000305747, ENST00000392687, 
ENST00000317647, ENST00000397206, 
ENST00000397209, ENST00000421711, 
ENST00000444448, ENST00000445023, 
ENST00000458381, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 12 X 8=17285 X 12 X 5=300
# samples 2210
** MAII scorelog2(22/1728*10)=-2.97352778863881
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/300*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: CERS6 [Title/Abstract] AND NOSTRIN [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: CERS6 [Title/Abstract] AND NOSTRIN [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CERS6(169404211)-NOSTRIN(169699501), # samples:2
CERS6(169404211)-NOSTRIN(169707593), # samples:2
Anticipated loss of major functional domain due to fusion event.CERS6-NOSTRIN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CERS6-NOSTRIN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CERS6-NOSTRIN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CERS6-NOSTRIN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CERS6-NOSTRIN seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CERS6-NOSTRIN seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCERS6

GO:0046513

ceramide biosynthetic process

17609214|17977534



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:169404211/chr2:169699501)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across CERS6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NOSTRIN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000305747CERS6chr2169404211+ENST00000458381NOSTRINchr2169699501+21368632872050587
ENST00000305747CERS6chr2169404211+ENST00000444448NOSTRINchr2169699501+24208632872050587
ENST00000305747CERS6chr2169404211+ENST00000317647NOSTRINchr2169699501+24248632871879530
ENST00000305747CERS6chr2169404211+ENST00000445023NOSTRINchr2169699501+19648632871879530
ENST00000305747CERS6chr2169404211+ENST00000397206NOSTRINchr2169699501+18808632871879531
ENST00000305747CERS6chr2169404211+ENST00000421711NOSTRINchr2169699501+18808632871879531
ENST00000305747CERS6chr2169404211+ENST00000397209NOSTRINchr2169699501+18808632871879531
ENST00000392687CERS6chr2169404211+ENST00000458381NOSTRINchr2169699501+17494761401663507
ENST00000392687CERS6chr2169404211+ENST00000444448NOSTRINchr2169699501+20334761401663507
ENST00000392687CERS6chr2169404211+ENST00000317647NOSTRINchr2169699501+20374761401492450
ENST00000392687CERS6chr2169404211+ENST00000445023NOSTRINchr2169699501+15774761401492450
ENST00000392687CERS6chr2169404211+ENST00000397206NOSTRINchr2169699501+14934761401492451
ENST00000392687CERS6chr2169404211+ENST00000421711NOSTRINchr2169699501+14934761401492451
ENST00000392687CERS6chr2169404211+ENST00000397209NOSTRINchr2169699501+14934761401492451
ENST00000305747CERS6chr2169404211+ENST00000458381NOSTRINchr2169707593+18398632871753488
ENST00000305747CERS6chr2169404211+ENST00000444448NOSTRINchr2169707593+21238632871753488
ENST00000305747CERS6chr2169404211+ENST00000317647NOSTRINchr2169707593+22988632871753488
ENST00000305747CERS6chr2169404211+ENST00000445023NOSTRINchr2169707593+18388632871753488
ENST00000305747CERS6chr2169404211+ENST00000397206NOSTRINchr2169707593+17548632871753489
ENST00000305747CERS6chr2169404211+ENST00000421711NOSTRINchr2169707593+17548632871753489
ENST00000305747CERS6chr2169404211+ENST00000397209NOSTRINchr2169707593+17548632871753489
ENST00000392687CERS6chr2169404211+ENST00000458381NOSTRINchr2169707593+14524761401366408
ENST00000392687CERS6chr2169404211+ENST00000444448NOSTRINchr2169707593+17364761401366408
ENST00000392687CERS6chr2169404211+ENST00000317647NOSTRINchr2169707593+19114761401366408
ENST00000392687CERS6chr2169404211+ENST00000445023NOSTRINchr2169707593+14514761401366408
ENST00000392687CERS6chr2169404211+ENST00000397206NOSTRINchr2169707593+13674761401366409
ENST00000392687CERS6chr2169404211+ENST00000421711NOSTRINchr2169707593+13674761401366409
ENST00000392687CERS6chr2169404211+ENST00000397209NOSTRINchr2169707593+13674761401366409
ENST00000305747CERS6chr2169404211+ENST00000458381NOSTRINchr2169699502+21368632872050587
ENST00000305747CERS6chr2169404211+ENST00000444448NOSTRINchr2169699502+24208632872050587
ENST00000305747CERS6chr2169404211+ENST00000317647NOSTRINchr2169699502+24248632871879530
ENST00000305747CERS6chr2169404211+ENST00000445023NOSTRINchr2169699502+19648632871879530
ENST00000305747CERS6chr2169404211+ENST00000397206NOSTRINchr2169699502+18808632871879531
ENST00000305747CERS6chr2169404211+ENST00000421711NOSTRINchr2169699502+18808632871879531
ENST00000305747CERS6chr2169404211+ENST00000397209NOSTRINchr2169699502+18808632871879531
ENST00000392687CERS6chr2169404211+ENST00000458381NOSTRINchr2169699502+17494761401663507
ENST00000392687CERS6chr2169404211+ENST00000444448NOSTRINchr2169699502+20334761401663507
ENST00000392687CERS6chr2169404211+ENST00000317647NOSTRINchr2169699502+20374761401492450
ENST00000392687CERS6chr2169404211+ENST00000445023NOSTRINchr2169699502+15774761401492450
ENST00000392687CERS6chr2169404211+ENST00000397206NOSTRINchr2169699502+14934761401492451
ENST00000392687CERS6chr2169404211+ENST00000421711NOSTRINchr2169699502+14934761401492451
ENST00000392687CERS6chr2169404211+ENST00000397209NOSTRINchr2169699502+14934761401492451
ENST00000305747CERS6chr2169404211+ENST00000458381NOSTRINchr2169707594+18398632871753488
ENST00000305747CERS6chr2169404211+ENST00000444448NOSTRINchr2169707594+21238632871753488
ENST00000305747CERS6chr2169404211+ENST00000317647NOSTRINchr2169707594+22988632871753488
ENST00000305747CERS6chr2169404211+ENST00000445023NOSTRINchr2169707594+18388632871753488
ENST00000305747CERS6chr2169404211+ENST00000397206NOSTRINchr2169707594+17548632871753489
ENST00000305747CERS6chr2169404211+ENST00000421711NOSTRINchr2169707594+17548632871753489
ENST00000305747CERS6chr2169404211+ENST00000397209NOSTRINchr2169707594+17548632871753489
ENST00000392687CERS6chr2169404211+ENST00000458381NOSTRINchr2169707594+14524761401366408
ENST00000392687CERS6chr2169404211+ENST00000444448NOSTRINchr2169707594+17364761401366408
ENST00000392687CERS6chr2169404211+ENST00000317647NOSTRINchr2169707594+19114761401366408
ENST00000392687CERS6chr2169404211+ENST00000445023NOSTRINchr2169707594+14514761401366408
ENST00000392687CERS6chr2169404211+ENST00000397206NOSTRINchr2169707594+13674761401366409
ENST00000392687CERS6chr2169404211+ENST00000421711NOSTRINchr2169707594+13674761401366409
ENST00000392687CERS6chr2169404211+ENST00000397209NOSTRINchr2169707594+13674761401366409

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000305747ENST00000458381CERS6chr2169404211+NOSTRINchr2169699501+0.0064113770.99358857
ENST00000305747ENST00000444448CERS6chr2169404211+NOSTRINchr2169699501+0.0049403360.9950597
ENST00000305747ENST00000317647CERS6chr2169404211+NOSTRINchr2169699501+0.005737080.9942629
ENST00000305747ENST00000445023CERS6chr2169404211+NOSTRINchr2169699501+0.0082875440.99171245
ENST00000305747ENST00000397206CERS6chr2169404211+NOSTRINchr2169699501+0.0087019940.9912981
ENST00000305747ENST00000421711CERS6chr2169404211+NOSTRINchr2169699501+0.0087019940.9912981
ENST00000305747ENST00000397209CERS6chr2169404211+NOSTRINchr2169699501+0.0087019940.9912981
ENST00000392687ENST00000458381CERS6chr2169404211+NOSTRINchr2169699501+0.0042750250.99572504
ENST00000392687ENST00000444448CERS6chr2169404211+NOSTRINchr2169699501+0.0031186340.99688137
ENST00000392687ENST00000317647CERS6chr2169404211+NOSTRINchr2169699501+0.0036545260.99634546
ENST00000392687ENST00000445023CERS6chr2169404211+NOSTRINchr2169699501+0.0043294850.99567056
ENST00000392687ENST00000397206CERS6chr2169404211+NOSTRINchr2169699501+0.0043444070.99565554
ENST00000392687ENST00000421711CERS6chr2169404211+NOSTRINchr2169699501+0.0043444070.99565554
ENST00000392687ENST00000397209CERS6chr2169404211+NOSTRINchr2169699501+0.0043444070.99565554
ENST00000305747ENST00000458381CERS6chr2169404211+NOSTRINchr2169707593+0.0131771260.98682284
ENST00000305747ENST00000444448CERS6chr2169404211+NOSTRINchr2169707593+0.0091945590.99080545
ENST00000305747ENST00000317647CERS6chr2169404211+NOSTRINchr2169707593+0.0093627660.99063724
ENST00000305747ENST00000445023CERS6chr2169404211+NOSTRINchr2169707593+0.0134727760.98652726
ENST00000305747ENST00000397206CERS6chr2169404211+NOSTRINchr2169707593+0.0142989560.9857011
ENST00000305747ENST00000421711CERS6chr2169404211+NOSTRINchr2169707593+0.0142989560.9857011
ENST00000305747ENST00000397209CERS6chr2169404211+NOSTRINchr2169707593+0.0142989560.9857011
ENST00000392687ENST00000458381CERS6chr2169404211+NOSTRINchr2169707593+0.0072717560.99272823
ENST00000392687ENST00000444448CERS6chr2169404211+NOSTRINchr2169707593+0.0048361380.9951638
ENST00000392687ENST00000317647CERS6chr2169404211+NOSTRINchr2169707593+0.005323530.9946765
ENST00000392687ENST00000445023CERS6chr2169404211+NOSTRINchr2169707593+0.0073536680.99264634
ENST00000392687ENST00000397206CERS6chr2169404211+NOSTRINchr2169707593+0.0073197750.9926803
ENST00000392687ENST00000421711CERS6chr2169404211+NOSTRINchr2169707593+0.0073197750.9926803
ENST00000392687ENST00000397209CERS6chr2169404211+NOSTRINchr2169707593+0.0073197750.9926803
ENST00000305747ENST00000458381CERS6chr2169404211+NOSTRINchr2169699502+0.0064113770.99358857
ENST00000305747ENST00000444448CERS6chr2169404211+NOSTRINchr2169699502+0.0049403360.9950597
ENST00000305747ENST00000317647CERS6chr2169404211+NOSTRINchr2169699502+0.005737080.9942629
ENST00000305747ENST00000445023CERS6chr2169404211+NOSTRINchr2169699502+0.0082875440.99171245
ENST00000305747ENST00000397206CERS6chr2169404211+NOSTRINchr2169699502+0.0087019940.9912981
ENST00000305747ENST00000421711CERS6chr2169404211+NOSTRINchr2169699502+0.0087019940.9912981
ENST00000305747ENST00000397209CERS6chr2169404211+NOSTRINchr2169699502+0.0087019940.9912981
ENST00000392687ENST00000458381CERS6chr2169404211+NOSTRINchr2169699502+0.0042750250.99572504
ENST00000392687ENST00000444448CERS6chr2169404211+NOSTRINchr2169699502+0.0031186340.99688137
ENST00000392687ENST00000317647CERS6chr2169404211+NOSTRINchr2169699502+0.0036545260.99634546
ENST00000392687ENST00000445023CERS6chr2169404211+NOSTRINchr2169699502+0.0043294850.99567056
ENST00000392687ENST00000397206CERS6chr2169404211+NOSTRINchr2169699502+0.0043444070.99565554
ENST00000392687ENST00000421711CERS6chr2169404211+NOSTRINchr2169699502+0.0043444070.99565554
ENST00000392687ENST00000397209CERS6chr2169404211+NOSTRINchr2169699502+0.0043444070.99565554
ENST00000305747ENST00000458381CERS6chr2169404211+NOSTRINchr2169707594+0.0131771260.98682284
ENST00000305747ENST00000444448CERS6chr2169404211+NOSTRINchr2169707594+0.0091945590.99080545
ENST00000305747ENST00000317647CERS6chr2169404211+NOSTRINchr2169707594+0.0093627660.99063724
ENST00000305747ENST00000445023CERS6chr2169404211+NOSTRINchr2169707594+0.0134727760.98652726
ENST00000305747ENST00000397206CERS6chr2169404211+NOSTRINchr2169707594+0.0142989560.9857011
ENST00000305747ENST00000421711CERS6chr2169404211+NOSTRINchr2169707594+0.0142989560.9857011
ENST00000305747ENST00000397209CERS6chr2169404211+NOSTRINchr2169707594+0.0142989560.9857011
ENST00000392687ENST00000458381CERS6chr2169404211+NOSTRINchr2169707594+0.0072717560.99272823
ENST00000392687ENST00000444448CERS6chr2169404211+NOSTRINchr2169707594+0.0048361380.9951638
ENST00000392687ENST00000317647CERS6chr2169404211+NOSTRINchr2169707594+0.005323530.9946765
ENST00000392687ENST00000445023CERS6chr2169404211+NOSTRINchr2169707594+0.0073536680.99264634
ENST00000392687ENST00000397206CERS6chr2169404211+NOSTRINchr2169707594+0.0073197750.9926803
ENST00000392687ENST00000421711CERS6chr2169404211+NOSTRINchr2169707594+0.0073197750.9926803
ENST00000392687ENST00000397209CERS6chr2169404211+NOSTRINchr2169707594+0.0073197750.9926803

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

Top

Fusion Protein Breakpoint Sequences for CERS6-NOSTRIN

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide

Top

Potential FusionNeoAntigen Information of CERS6-NOSTRIN in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)

Top

Potential FusionNeoAntigen Information of CERS6-NOSTRIN in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)

Top

Fusion breakpoint peptide structures of CERS6-NOSTRIN

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

Top

Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of CERS6-NOSTRIN

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score

Top

Vaccine Design for the FusionNeoAntigens of CERS6-NOSTRIN

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence

Top

Information of the samples that have these potential fusion neoantigens of CERS6-NOSTRIN

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample

Top

Potential target of CAR-T therapy development for CERS6-NOSTRIN

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCERS6chr2:169404211chr2:169699501ENST00000305747+21035_5592385.0TransmembraneHelical
HgeneCERS6chr2:169404211chr2:169699501ENST00000392687+21135_5592393.0TransmembraneHelical
HgeneCERS6chr2:169404211chr2:169699502ENST00000305747+21035_5592385.0TransmembraneHelical
HgeneCERS6chr2:169404211chr2:169699502ENST00000392687+21135_5592393.0TransmembraneHelical
HgeneCERS6chr2:169404211chr2:169707593ENST00000305747+21035_5592385.0TransmembraneHelical
HgeneCERS6chr2:169404211chr2:169707593ENST00000392687+21135_5592393.0TransmembraneHelical
HgeneCERS6chr2:169404211chr2:169707594ENST00000305747+21035_5592385.0TransmembraneHelical
HgeneCERS6chr2:169404211chr2:169707594ENST00000392687+21135_5592393.0TransmembraneHelical

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

Top

Related Drugs to CERS6-NOSTRIN

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to CERS6-NOSTRIN

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource