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Fusion Protein:CNN3-ALG14

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CNN3-ALG14
	FusionPDB ID: 17681
	FusionGDB2.0 ID: 17681
		Hgene	Tgene
	Gene symbol	CNN3	ALG14
	Gene ID	1266	199857
	Gene name	calponin 3	ALG14 UDP-N-acetylglucosaminyltransferase subunit
	Synonyms	-	CMS15
	Cytomap	1p21.3	1p21.3
	Type of gene	protein-coding	protein-coding
	Description	calponin-3calponin 3, acidiccalponin, acidic isoformdJ639P13.2.2 (acidic calponin 3)	UDP-N-acetylglucosamine transferase subunit ALG14 homolog
	Modification date	20200313	20200313
	UniProtAcc	Q15417 Main function of 5'-partner protein: FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.	Q96F25 Main function of 5'-partner protein: FUNCTION: May be involved in protein N-glycosylation. May play a role in the second step of the dolichol-linked oligosaccharide pathway. May anchor the catalytic subunit ALG13 to the ER. {ECO:0000269\|PubMed:16100110}.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000370206, ENST00000394202, ENST00000538964, ENST00000487539, ENST00000545882,	ENST00000495856, ENST00000370205,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	5 X 6 X 5=150	7 X 7 X 5=245
	# samples	9	10
	** MAII score	log2(9/150*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/245*10)=-1.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: CNN3 [Title/Abstract] AND ALG14 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: CNN3 [Title/Abstract] AND ALG14 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CNN3(95392394)-ALG14(95448862), # samples:6 ALG14(95492685)-CNN3(95369080), # samples:1
Anticipated loss of major functional domain due to fusion event.	CNN3-ALG14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CNN3-ALG14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CNN3-ALG14 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. CNN3-ALG14 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:95392394/chr1:95448862)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across CNN3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ALG14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000370206	CNN3	chr1	95392394	-	ENST00000370205	ALG14	chr1	95492816	-	9473	441	32	583	183
ENST00000538964	CNN3	chr1	95392394	-	ENST00000370205	ALG14	chr1	95492816	-	9172	140	4182	4667	161
ENST00000394202	CNN3	chr1	95392394	-	ENST00000370205	ALG14	chr1	95492816	-	9338	306	4348	4833	161

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000370206	ENST00000370205	CNN3	chr1	95392394	-	ALG14	chr1	95492816	-	0.08587428	0.9141257
ENST00000538964	ENST00000370205	CNN3	chr1	95392394	-	ALG14	chr1	95492816	-	0.08298756	0.91701245
ENST00000394202	ENST00000370205	CNN3	chr1	95392394	-	ALG14	chr1	95492816	-	0.086352356	0.9136476

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for CNN3-ALG14

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
CNN3	chr1	95392394	ALG14	chr1	95492816	441	136	GPFLWALGRSQEQVYQILHSPNSKKP

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Potential FusionNeoAntigen Information of CNN3-ALG14 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

CNN3-ALG14_95392394_95492816.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B13:02	SQEQVYQI	0.9938	0.7142	9	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B18:01	QEQVYQIL	0.9861	0.8251	10	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B13:01	SQEQVYQI	0.9814	0.9393	9	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B52:01	SQEQVYQI	0.97	0.9485	9	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B58:01	RSQEQVYQI	0.9946	0.9408	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B15:16	RSQEQVYQI	0.9926	0.81	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B58:02	RSQEQVYQI	0.9896	0.9509	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B15:17	RSQEQVYQI	0.989	0.893	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-A02:22	ALGRSQEQV	0.9816	0.694	5	14
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-A02:13	ALGRSQEQV	0.9775	0.7672	5	14
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-A02:27	ALGRSQEQV	0.9727	0.6987	5	14
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B57:03	RSQEQVYQI	0.9725	0.9842	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-A02:38	ALGRSQEQV	0.9648	0.7478	5	14
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B39:01	SQEQVYQIL	0.9474	0.8863	9	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-A32:13	RSQEQVYQI	0.9341	0.8949	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-A02:19	ALGRSQEQV	0.9257	0.5701	5	14
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B18:01	QEQVYQILH	0.92	0.7601	10	19
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-A30:08	RSQEQVYQI	0.9092	0.7264	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B39:13	SQEQVYQIL	0.8808	0.8818	9	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B38:02	SQEQVYQIL	0.8309	0.9576	9	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B13:01	SQEQVYQIL	0.8172	0.8504	9	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B38:01	SQEQVYQIL	0.8039	0.954	9	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B13:02	RSQEQVYQI	0.6388	0.8802	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B13:01	RSQEQVYQI	0.4124	0.9278	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B52:01	RSQEQVYQI	0.2806	0.9496	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B52:01	SQEQVYQIL	0.2007	0.7514	9	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B27:07	GRSQEQVYQI	0.9994	0.537	7	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B15:01	ALGRSQEQVY	0.9973	0.8602	5	15
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B15:25	ALGRSQEQVY	0.9366	0.9145	5	15
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B45:01	QEQVYQILHSP	0.9962	0.9794	10	21
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-C15:04	RSQEQVYQI	0.9995	0.8492	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-C15:06	RSQEQVYQI	0.9994	0.856	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-C08:15	SQEQVYQIL	0.9962	0.9573	9	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-C08:13	SQEQVYQIL	0.9851	0.9442	9	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-C08:04	SQEQVYQIL	0.9851	0.9442	9	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-A02:02	ALGRSQEQV	0.9811	0.5204	5	14
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-C08:03	SQEQVYQIL	0.9809	0.9755	9	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B39:08	SQEQVYQIL	0.858	0.7903	9	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B39:05	SQEQVYQIL	0.8306	0.8645	9	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-C02:06	RSQEQVYQI	0.7831	0.9266	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-C12:04	RSQEQVYQI	0.7487	0.9908	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-C06:03	RSQEQVYQI	0.7403	0.9914	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B14:03	SQEQVYQIL	0.7149	0.6956	9	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B15:07	ALGRSQEQVY	0.994	0.6332	5	15
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B15:04	ALGRSQEQVY	0.9495	0.8885	5	15
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B40:04	QEQVYQIL	0.9983	0.6793	10	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B18:05	QEQVYQIL	0.9861	0.8251	10	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B18:03	QEQVYQIL	0.9783	0.8118	10	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B41:03	QEQVYQIL	0.9362	0.6588	10	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-C15:09	RSQEQVYQI	0.9995	0.8492	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-C15:02	RSQEQVYQI	0.9995	0.7905	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-C15:05	RSQEQVYQI	0.9995	0.9168	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-C08:02	SQEQVYQIL	0.9962	0.9573	9	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-C16:02	RSQEQVYQI	0.9909	0.9921	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-A32:01	RSQEQVYQI	0.9908	0.92	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B57:04	RSQEQVYQI	0.9897	0.7444	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B58:06	RSQEQVYQI	0.9891	0.8859	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-C08:01	SQEQVYQIL	0.9809	0.9755	9	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B39:02	SQEQVYQIL	0.9614	0.8873	9	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B39:31	SQEQVYQIL	0.9607	0.8882	9	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B57:02	RSQEQVYQI	0.954	0.9397	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B18:05	QEQVYQILH	0.92	0.7601	10	19
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B18:06	QEQVYQILH	0.9003	0.773	10	19
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B18:11	QEQVYQILH	0.8786	0.7681	10	19
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-C17:01	RSQEQVYQI	0.8629	0.9713	8	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B39:11	SQEQVYQIL	0.8582	0.7597	9	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B38:05	SQEQVYQIL	0.8039	0.954	9	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B15:73	SQEQVYQIL	0.754	0.654	9	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B15:30	SQEQVYQIL	0.6822	0.5893	9	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B27:06	GRSQEQVYQI	0.9993	0.6253	7	17
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B15:34	ALGRSQEQVY	0.9973	0.8602	5	15
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B15:33	ALGRSQEQVY	0.9973	0.8602	5	15
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B15:125	ALGRSQEQVY	0.9973	0.8602	5	15
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B15:27	ALGRSQEQVY	0.9971	0.8669	5	15
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B15:135	ALGRSQEQVY	0.997	0.89	5	15
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B15:50	ALGRSQEQVY	0.9962	0.8918	5	15
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B15:35	ALGRSQEQVY	0.9935	0.8492	5	15
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B15:12	ALGRSQEQVY	0.9899	0.8972	5	15
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B15:39	ALGRSQEQVY	0.9416	0.8378	5	15
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B27:06	GRSQEQVYQIL	1	0.6613	7	18
CNN3-ALG14	chr1	95392394	chr1	95492816	441	HLA-B27:09	GRSQEQVYQIL	0.9999	0.523	7	18

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Potential FusionNeoAntigen Information of CNN3-ALG14 in HLA II

CNN3-ALG14_95392394_95492816.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0101	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0101	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0101	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0103	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0103	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0105	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0105	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0105	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0107	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0107	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0107	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0109	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0109	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0109	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0111	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0111	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0111	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0113	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0113	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0113	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0115	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0115	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0115	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0117	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0117	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0117	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0119	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0119	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0119	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0121	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0121	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0121	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0125	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0125	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0125	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0127	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0127	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0127	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0129	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0129	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0129	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0131	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0131	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0131	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0401	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0401	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0401	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0405	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0405	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0407	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0407	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0407	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0409	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0415	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0415	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0417	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0419	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0419	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0419	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0424	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0424	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0427	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0429	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0429	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0430	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0430	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0431	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0431	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0431	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0433	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0433	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0433	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0434	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0434	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0434	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0435	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0435	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0435	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0436	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0436	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0438	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0438	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0438	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0443	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0443	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0443	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0445	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0445	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0447	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0447	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0447	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0448	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0448	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0449	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0451	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0453	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0454	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0454	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0454	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0457	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0457	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0458	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0461	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0461	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0461	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0462	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0462	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0463	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0463	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0463	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0464	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0464	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0464	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0466	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0469	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0472	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0472	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0474	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0474	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0474	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0475	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0475	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0475	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0476	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0476	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0476	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0477	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0477	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0479	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0480	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0480	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0480	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0482	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0482	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0482	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0483	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0483	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0484	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0484	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0486	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0486	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0487	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0487	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0489	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0489	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0802	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0802	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0803	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0807	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0807	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0808	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0809	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0809	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0811	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0813	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0813	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0814	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0815	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0815	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0819	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0821	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0821	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0823	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0824	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0824	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0825	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0827	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0830	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0830	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0832	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0832	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0833	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0834	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0835	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0836	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0837	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-0838	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1001	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1001	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1001	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1003	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1003	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1003	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1105	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1105	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1108	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1119	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1127	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1130	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1130	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1130	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1131	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1137	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1145	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1164	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1169	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1172	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1172	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1180	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1187	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1216	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1216	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1216	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1307	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1326	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1326	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1347	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1356	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1358	GPFLWALGRSQEQVY	0	15
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1360	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1360	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1367	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1367	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1382	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1386	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1402	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1402	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1403	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1409	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1427	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1427	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1430	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1440	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1441	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1441	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1446	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1446	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1446	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1467	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1477	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1489	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1494	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1494	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1502	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1502	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1508	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1508	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1511	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1511	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1514	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1514	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1515	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1515	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1515	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1519	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1519	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1526	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1526	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1527	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1527	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1527	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1529	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1530	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1531	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1531	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1534	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1534	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1534	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1538	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1538	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1539	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1539	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1544	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1544	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1547	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1547	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1601	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1601	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1601	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1602	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1602	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1602	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1603	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1603	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1603	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1604	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1604	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1604	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1605	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1605	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1605	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1607	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1607	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1607	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1608	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1608	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1608	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1609	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1609	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1609	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1610	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1610	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1610	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1611	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1611	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1611	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1612	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1612	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1612	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1614	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1614	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1614	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1615	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1616	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1616	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB1-1616	SQEQVYQILHSPNSK	9	24
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB3-0215	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB3-0217	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB3-0217	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB5-0102	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB5-0102	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB5-0103	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB5-0103	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB5-0104	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB5-0108N	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB5-0108N	QEQVYQILHSPNSKK	10	25
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB5-0111	EQVYQILHSPNSKKP	11	26
CNN3-ALG14	chr1	95392394	chr1	95492816	441	DRB5-0203	EQVYQILHSPNSKKP	11	26

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Fusion breakpoint peptide structures of CNN3-ALG14

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
5028	LGRSQEQVYQILHS	CNN3	ALG14	chr1	95392394	chr1	95492816	441

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of CNN3-ALG14

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	5028	LGRSQEQVYQILHS	-7.9962	-8.1096
HLA-B14:02	3BVN	5028	LGRSQEQVYQILHS	-5.70842	-6.74372
HLA-B52:01	3W39	5028	LGRSQEQVYQILHS	-6.83737	-6.95077
HLA-B52:01	3W39	5028	LGRSQEQVYQILHS	-4.4836	-5.5189
HLA-A11:01	4UQ2	5028	LGRSQEQVYQILHS	-10.0067	-10.1201
HLA-A11:01	4UQ2	5028	LGRSQEQVYQILHS	-9.03915	-10.0745
HLA-A24:02	5HGA	5028	LGRSQEQVYQILHS	-6.56204	-6.67544
HLA-A24:02	5HGA	5028	LGRSQEQVYQILHS	-5.42271	-6.45801
HLA-B44:05	3DX8	5028	LGRSQEQVYQILHS	-7.85648	-8.89178
HLA-B44:05	3DX8	5028	LGRSQEQVYQILHS	-5.3978	-5.5112
HLA-A02:01	6TDR	5028	LGRSQEQVYQILHS	-3.37154	-4.40684

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Vaccine Design for the FusionNeoAntigens of CNN3-ALG14

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
CNN3-ALG14	chr1	95392394	chr1	95492816	10	18	QEQVYQIL	AAGAACAAGTATACCAAATACTAC
CNN3-ALG14	chr1	95392394	chr1	95492816	10	19	QEQVYQILH	AAGAACAAGTATACCAAATACTACATT
CNN3-ALG14	chr1	95392394	chr1	95492816	10	21	QEQVYQILHSP	AAGAACAAGTATACCAAATACTACATTCACCGA
CNN3-ALG14	chr1	95392394	chr1	95492816	5	14	ALGRSQEQV	CTCTCGGCCGAAGTCAAGAACAAGTAT
CNN3-ALG14	chr1	95392394	chr1	95492816	5	15	ALGRSQEQVY	CTCTCGGCCGAAGTCAAGAACAAGTATACC
CNN3-ALG14	chr1	95392394	chr1	95492816	7	17	GRSQEQVYQI	GCCGAAGTCAAGAACAAGTATACCAAATAC
CNN3-ALG14	chr1	95392394	chr1	95492816	7	18	GRSQEQVYQIL	GCCGAAGTCAAGAACAAGTATACCAAATACTAC
CNN3-ALG14	chr1	95392394	chr1	95492816	8	17	RSQEQVYQI	GAAGTCAAGAACAAGTATACCAAATAC
CNN3-ALG14	chr1	95392394	chr1	95492816	9	17	SQEQVYQI	GTCAAGAACAAGTATACCAAATAC
CNN3-ALG14	chr1	95392394	chr1	95492816	9	18	SQEQVYQIL	GTCAAGAACAAGTATACCAAATACTAC

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
CNN3-ALG14	chr1	95392394	chr1	95492816	0	15	GPFLWALGRSQEQVY	GGCCCTTCCTATGGGCTCTCGGCCGAAGTCAAGAACAAGTATACC
CNN3-ALG14	chr1	95392394	chr1	95492816	10	25	QEQVYQILHSPNSKK	AAGAACAAGTATACCAAATACTACATTCACCGAATTCCAAGAAGC
CNN3-ALG14	chr1	95392394	chr1	95492816	11	26	EQVYQILHSPNSKKP	AACAAGTATACCAAATACTACATTCACCGAATTCCAAGAAGCCGG
CNN3-ALG14	chr1	95392394	chr1	95492816	9	24	SQEQVYQILHSPNSK	GTCAAGAACAAGTATACCAAATACTACATTCACCGAATTCCAAGA

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Information of the samples that have these potential fusion neoantigens of CNN3-ALG14

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
BRCA	CNN3-ALG14	chr1	95392394	ENST00000370206	chr1	95492816	ENST00000370205	TCGA-A1-A0SH-01A

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Potential target of CAR-T therapy development for CNN3-ALG14

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to CNN3-ALG14

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CNN3-ALG14

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)