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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:CTNND1-ARHGAP26

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CTNND1-ARHGAP26
FusionPDB ID: 20357
FusionGDB2.0 ID: 20357
HgeneTgene
Gene symbol

CTNND1

ARHGAP26

Gene ID

100528016

23092

Gene nameTMX2-CTNND1 readthrough (NMD candidate)Rho GTPase activating protein 26
SynonymsCAS|CTNND1|p120(cas)|p120(ctn)GRAF|GRAF1|OPHN1L|OPHN1L1
Cytomap

11q12.1

5q31.3

Type of genencRNAprotein-coding
DescriptionCadherin-associated Src substrateCatenin delta-1TMX2-CTNND1 readthrough (non-protein coding)p120 cateninrho GTPase-activating protein 26GTPase regulator associated with focal adhesion kinase pp125(FAK)oligophrenin-1-like protein
Modification date2020031320200313
UniProtAcc

O60716

Main function of 5'-partner protein: FUNCTION: Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:20371349}.

Q9UNA1

Main function of 5'-partner protein: FUNCTION: GTPase-activating protein for RHOA and CDC42.
Ensembl transtripts involved in fusion geneENST idsENST00000358694, ENST00000360682, 
ENST00000361332, ENST00000361391, 
ENST00000361796, ENST00000399039, 
ENST00000399050, ENST00000415361, 
ENST00000426142, ENST00000428599, 
ENST00000524630, ENST00000525902, 
ENST00000526357, ENST00000526772, 
ENST00000526938, ENST00000527467, 
ENST00000528232, ENST00000528621, 
ENST00000529526, ENST00000529873, 
ENST00000529919, ENST00000529986, 
ENST00000530094, ENST00000530748, 
ENST00000531014, ENST00000532245, 
ENST00000532463, ENST00000532649, 
ENST00000532787, ENST00000532844, 
ENST00000533667, ENST00000534579, 
ENST00000486650, ENST00000274498, 
ENST00000378004, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score29 X 18 X 15=783023 X 27 X 10=6210
# samples 3530
** MAII scorelog2(35/7830*10)=-4.48358548034607
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(30/6210*10)=-4.37155886261196
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: CTNND1 [Title/Abstract] AND ARHGAP26 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: CTNND1 [Title/Abstract] AND ARHGAP26 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ARHGAP26(142311690)-CTNND1(57578870), # samples:1
CTNND1(57577695)-ARHGAP26(142393644), # samples:1
Anticipated loss of major functional domain due to fusion event.ARHGAP26-CTNND1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP26-CTNND1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CTNND1-ARHGAP26 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CTNND1-ARHGAP26 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CTNND1-ARHGAP26 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CTNND1-ARHGAP26 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:142311690/chr5:57578870)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across CTNND1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARHGAP26 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000524630CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10783304551342171234
ENST00000524630CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+8422304551343821289
ENST00000529919CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10619288133140531240
ENST00000529919CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+8258288133142181295
ENST00000399039CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10619288133140531240
ENST00000399039CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+8258288133142181295
ENST00000360682CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10859312157142931240
ENST00000360682CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+8498312157144581295
ENST00000361796CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10841310357142751234
ENST00000361796CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+8480310357144401289
ENST00000361391CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10806306853642401234
ENST00000361391CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+8445306853644051289
ENST00000530094CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10325258730137591152
ENST00000530094CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+7964258730139241207
ENST00000428599CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10614287634440481234
ENST00000428599CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+8253287634442131289
ENST00000361332CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10806306853642401234
ENST00000361332CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+8445306853644051289
ENST00000527467CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+95821844683016982
ENST00000527467CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+722118446831811037
ENST00000415361CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10343260530137771158
ENST00000415361CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+7982260530139421213
ENST00000532245CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10253251528636871133
ENST00000532245CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+7892251528638521188
ENST00000532463CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+1034726096837811237
ENST00000532463CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+798626096839461292
ENST00000528232CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10343260530137771158
ENST00000528232CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+7982260530139421213
ENST00000529986CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10325258730137591152
ENST00000529986CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+7964258730139241207
ENST00000531014CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+95641826682998976
ENST00000531014CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+720318266831631031
ENST00000358694CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10733299546341671234
ENST00000358694CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+8372299546343321289
ENST00000526772CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+95641826682998976
ENST00000526772CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+720318266831631031
ENST00000532787CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10325258730137591152
ENST00000532787CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+7964258730139241207
ENST00000533667CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+95641826682998976
ENST00000533667CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+720318266831631031
ENST00000529873CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10505276727139391222
ENST00000529873CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+8144276727141041277
ENST00000525902CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+95821844683016982
ENST00000525902CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+722118446831811037
ENST00000529526CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10697295946341311222
ENST00000529526CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+8336295946342961277
ENST00000532649CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10624288639040581222
ENST00000532649CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+8263288639042231277
ENST00000426142CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+1039826606838321254
ENST00000426142CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+803726606839971309
ENST00000532844CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10523278527139571228
ENST00000532844CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+8162278527141221283
ENST00000528621CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10505276727139391222
ENST00000528621CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+8144276727141041277
ENST00000399050CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10824308653642581240
ENST00000399050CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+8463308653644231295
ENST00000526357CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10505276727139391222
ENST00000526357CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+8144276727141041277
ENST00000530748CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10523278527139571228
ENST00000530748CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+8162278527141221283
ENST00000534579CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+1062228846440561330
ENST00000534579CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+826128846442211385
ENST00000526938CTNND1chr1157577695+ENST00000378004ARHGAP26chr5142393644+10611287332340451240
ENST00000526938CTNND1chr1157577695+ENST00000274498ARHGAP26chr5142393644+8250287332342101295

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000524630ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0004800980.99951994
ENST00000524630ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0013630750.9986369
ENST00000529919ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0005252580.9994747
ENST00000529919ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0017104780.9982895
ENST00000399039ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0005252580.9994747
ENST00000399039ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0017104780.9982895
ENST00000360682ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0006272850.9993728
ENST00000360682ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0018846060.9981154
ENST00000361796ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0004586480.9995414
ENST00000361796ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0012009490.9987991
ENST00000361391ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0004381180.99956185
ENST00000361391ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0011460870.9988539
ENST00000530094ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0003616510.9996383
ENST00000530094ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0009968180.99900323
ENST00000428599ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0003858220.9996141
ENST00000428599ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0010646950.9989353
ENST00000361332ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0004381180.99956185
ENST00000361332ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0011460870.9988539
ENST00000527467ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0003660390.9996339
ENST00000527467ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0005625230.9994375
ENST00000415361ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0004949840.99950504
ENST00000415361ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0015669260.99843305
ENST00000532245ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0003306460.9996693
ENST00000532245ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0009148290.9990852
ENST00000532463ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0003557530.9996443
ENST00000532463ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0009666880.99903333
ENST00000528232ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0004949840.99950504
ENST00000528232ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0015669260.99843305
ENST00000529986ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0003616510.9996383
ENST00000529986ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0009968180.99900323
ENST00000531014ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0004436450.99955636
ENST00000531014ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0006425180.9993575
ENST00000358694ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0004310830.9995689
ENST00000358694ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0011563940.99884355
ENST00000526772ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0004436450.99955636
ENST00000526772ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0006425180.9993575
ENST00000532787ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0003616510.9996383
ENST00000532787ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0009968180.99900323
ENST00000533667ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0004436450.99955636
ENST00000533667ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0006425180.9993575
ENST00000529873ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0004075990.99959236
ENST00000529873ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0011451560.9988549
ENST00000525902ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0003660390.9996339
ENST00000525902ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0005625230.9994375
ENST00000529526ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0004643050.9995357
ENST00000529526ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0012314290.9987685
ENST00000532649ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0004567170.9995433
ENST00000532649ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0012447490.9987552
ENST00000426142ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0003693870.9996306
ENST00000426142ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0009844020.99901557
ENST00000532844ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0005507170.9994493
ENST00000532844ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0018051170.9981949
ENST00000528621ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0004075990.99959236
ENST00000528621ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0011451560.9988549
ENST00000399050ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0005986040.99940145
ENST00000399050ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0017975020.99820244
ENST00000526357ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0004075990.99959236
ENST00000526357ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0011451560.9988549
ENST00000530748ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0005507170.9994493
ENST00000530748ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0018051170.9981949
ENST00000534579ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0004509660.999549
ENST00000534579ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0012254640.99877447
ENST00000526938ENST00000378004CTNND1chr1157577695+ARHGAP26chr5142393644+0.0005094950.9994905
ENST00000526938ENST00000274498CTNND1chr1157577695+ARHGAP26chr5142393644+0.0016323920.9983676

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for CTNND1-ARHGAP26

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
CTNND1chr1157577695ARHGAP26chr51423936441826574LQTIWGYKELRKPLEKEGWKKSDFQV
CTNND1chr1157577695ARHGAP26chr51423936441844580LQTIWGYKELRKPLEKEGWKKSDFQV
CTNND1chr1157577695ARHGAP26chr51423936442515731LQTIWGYKELRKPLEKEGWKKSDFQV
CTNND1chr1157577695ARHGAP26chr51423936442587750LQTIWGYKELRKPLEKEGWKKSDFQV
CTNND1chr1157577695ARHGAP26chr51423936442605756LQTIWGYKELRKPLEKEGWKKSDFQV
CTNND1chr1157577695ARHGAP26chr51423936442609835LQTIWGYKELRKPLEKEGWKKSDFQV
CTNND1chr1157577695ARHGAP26chr51423936442660852LQTIWGYKELRKPLEKEGWKKSDFQV
CTNND1chr1157577695ARHGAP26chr51423936442767820LQTIWGYKELRKPLEKEGWKKSDFQV
CTNND1chr1157577695ARHGAP26chr51423936442785826LQTIWGYKELRKPLEKEGWKKSDFQV
CTNND1chr1157577695ARHGAP26chr51423936442873838LQTIWGYKELRKPLEKEGWKKSDFQV
CTNND1chr1157577695ARHGAP26chr51423936442876832LQTIWGYKELRKPLEKEGWKKSDFQV
CTNND1chr1157577695ARHGAP26chr51423936442881838LQTIWGYKELRKPLEKEGWKKSDFQV
CTNND1chr1157577695ARHGAP26chr51423936442884928LQTIWGYKELRKPLEKEGWKKSDFQV
CTNND1chr1157577695ARHGAP26chr51423936442886820LQTIWGYKELRKPLEKEGWKKSDFQV
CTNND1chr1157577695ARHGAP26chr51423936442959820LQTIWGYKELRKPLEKEGWKKSDFQV
CTNND1chr1157577695ARHGAP26chr51423936442995832LQTIWGYKELRKPLEKEGWKKSDFQV
CTNND1chr1157577695ARHGAP26chr51423936443045832LQTIWGYKELRKPLEKEGWKKSDFQV
CTNND1chr1157577695ARHGAP26chr51423936443068832LQTIWGYKELRKPLEKEGWKKSDFQV
CTNND1chr1157577695ARHGAP26chr51423936443086838LQTIWGYKELRKPLEKEGWKKSDFQV
CTNND1chr1157577695ARHGAP26chr51423936443103832LQTIWGYKELRKPLEKEGWKKSDFQV
CTNND1chr1157577695ARHGAP26chr51423936443121838LQTIWGYKELRKPLEKEGWKKSDFQV

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Potential FusionNeoAntigen Information of CTNND1-ARHGAP26 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
CTNND1-ARHGAP26_57577695_142393644.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
CTNND1-ARHGAP26chr1157577695chr51423936442995HLA-B47:01KELRKPLEK0.68840.5534716
CTNND1-ARHGAP26chr1157577695chr51423936442995HLA-B27:02LRKPLEKEGW0.99880.6409919

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Potential FusionNeoAntigen Information of CTNND1-ARHGAP26 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
CTNND1-ARHGAP26_57577695_142393644.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0801IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0801TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0801WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0801QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0802IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0802TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0803IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0803TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0803QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0803WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0805IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0805TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0805WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0805QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0807IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0807TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0808IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0808TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0808WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0808QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0809IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0809TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0811IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0811TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0811WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0811QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0813IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0813TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0814IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0814TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0814QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0814WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0815IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0815TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0816IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0816TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0816WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0816QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0818IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0818TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0818WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0818QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0821IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0821TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0823IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0823TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0823QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0823WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0824IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0824TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0825IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0826IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0826TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0826WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0826QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0827IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0827TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0827QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0827WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0829IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0829TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0829QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0829WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0830IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0830TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0832IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0832TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0832WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0832QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0833IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0833TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0833QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0833WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0835IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0835TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0835QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0835WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0836IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0836TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0836QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0836WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0837IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0837TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0837QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0837WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0838IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0838TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0838QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0838WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0839IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0839TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0839WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0839QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0840IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0840TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0840WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-0840QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1101IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1101TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1105IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1105TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1105WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1108IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1108TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1109IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1109TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1110IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1110TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1112IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1112TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1115IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1115TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1119IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1119TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1124IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1124TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1127IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1127TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1128IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1128TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1129IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1129TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1131IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1131TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1132IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1132TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1133IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1133TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1137IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1137TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1139IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1139TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1145IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1149IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1149TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1151IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1151TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1161IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1161TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1162IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1162TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1164IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1166IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1166TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1169IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1172IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1172TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1173IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1174IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1174TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1175IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1175TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1180IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1180TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1181IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1181TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1187IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1187TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1190IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1190TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1191IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1191TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1193IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1194IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1194TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1195IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1195TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1196IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1196TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1303IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1303TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1303WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1303QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1305IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1305TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1307IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1307TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-13100IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-13100TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-13101IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-13101TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-13101WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-13101QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1310IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1310TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1310WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1310QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1312IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1312TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1312WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1312QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1313IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1313TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1313WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1313QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1314IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1314TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1321IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1321TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1321WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1321QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1326IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1330IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1330TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1330QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1330WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1333IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1333TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1337IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1338IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1338TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1346IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1346TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1347IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1349IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1349TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1349WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1349QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1350IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1350TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1355IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1355TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1355WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1355QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1356IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1356TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1360IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1360TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1362IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1362TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1365IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1365TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1366IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1366TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1366WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1366QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1382IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1382TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1385IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1386IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1388IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1388TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1388WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1388QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1390IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1390TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1390WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1390QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1395IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1395TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1395WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1395QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1403IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1409IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1413IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1413TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1413WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1413QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1422IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1422TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1422WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1422QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1425IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1425TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1425WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1425QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1427IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1430IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1430TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1440IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1449IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1453IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1453TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1453WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1453QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1463IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1463TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1463WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1463QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1469IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1469TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1469WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1469QTIWGYKELRKPLEK116
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1477IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1485IWGYKELRKPLEKEG318
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1485TIWGYKELRKPLEKE217
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1485WGYKELRKPLEKEGW419
CTNND1-ARHGAP26chr1157577695chr51423936442995DRB1-1485QTIWGYKELRKPLEK116

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Fusion breakpoint peptide structures of CTNND1-ARHGAP26

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
10691YKELRKPLEKEGWKCTNND1ARHGAP26chr1157577695chr51423936442995

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of CTNND1-ARHGAP26

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN10691YKELRKPLEKEGWK-7.10743-7.22083
HLA-B14:023BVN10691YKELRKPLEKEGWK-3.79488-4.83018
HLA-B52:013W3910691YKELRKPLEKEGWK-6.78681-6.90021
HLA-B52:013W3910691YKELRKPLEKEGWK-3.75119-4.78649
HLA-A11:014UQ210691YKELRKPLEKEGWK-10.1888-11.2241
HLA-A11:014UQ210691YKELRKPLEKEGWK-6.59241-6.70581
HLA-A24:025HGA10691YKELRKPLEKEGWK-8.29771-9.33301
HLA-A24:025HGA10691YKELRKPLEKEGWK-8.23185-8.34525
HLA-B44:053DX810691YKELRKPLEKEGWK-7.25218-7.36558
HLA-B44:053DX810691YKELRKPLEKEGWK-3.76181-4.79711
HLA-A02:016TDR10691YKELRKPLEKEGWK-2.73959-3.77489

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Vaccine Design for the FusionNeoAntigens of CTNND1-ARHGAP26

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
CTNND1-ARHGAP26chr1157577695chr5142393644716KELRKPLEKAAGAAATCAGACTTTCAGGTCTACAAC
CTNND1-ARHGAP26chr1157577695chr5142393644919LRKPLEKEGWTCAGACTTTCAGGTCTACAACTCGAACAAA

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
CTNND1-ARHGAP26chr1157577695chr5142393644116QTIWGYKELRKPLEKCTGGAAAAAGAAGGATGGAAGAAATCAGACTTTCAGGTCTACAAC
CTNND1-ARHGAP26chr1157577695chr5142393644217TIWGYKELRKPLEKEGAAAAAGAAGGATGGAAGAAATCAGACTTTCAGGTCTACAACTCG
CTNND1-ARHGAP26chr1157577695chr5142393644318IWGYKELRKPLEKEGAAAGAAGGATGGAAGAAATCAGACTTTCAGGTCTACAACTCGAAC
CTNND1-ARHGAP26chr1157577695chr5142393644419WGYKELRKPLEKEGWGAAGGATGGAAGAAATCAGACTTTCAGGTCTACAACTCGAACAAA

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Information of the samples that have these potential fusion neoantigens of CTNND1-ARHGAP26

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
Non-CancerCTNND1-ARHGAP26chr1157577695ENST00000358694chr5142393644ENST000002744985373N

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Potential target of CAR-T therapy development for CTNND1-ARHGAP26

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to CTNND1-ARHGAP26

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CTNND1-ARHGAP26

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneARHGAP26C0033975Psychotic Disorders1PSYGENET