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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:CTTN-ANO1

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CTTN-ANO1
FusionPDB ID: 20549
FusionGDB2.0 ID: 20549
HgeneTgene
Gene symbol

CTTN

ANO1

Gene ID

2017

55107

Gene namecortactinanoctamin 1
SynonymsEMS1DOG1|ORAOV2|TAOS2|TMEM16A
Cytomap

11q13.3

11q13.3

Type of geneprotein-codingprotein-coding
Descriptionsrc substrate cortactin1110020L01Rikamplaxinems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)epididymis secretory sperm binding proteinoncogene EMS1anoctamin-1Ca2+-activated Cl- channelanoctamin 1, calcium activated chloride channelcalcium activated chloride channeldiscovered on gastrointestinal stromal tumors protein 1oral cancer overexpressed 2transmembrane protein 16A (eight membrane-spannin
Modification date2020032720200313
UniProtAcc

Q9P2B4

Main function of 5'-partner protein: FUNCTION: Regulates lamellipodial actin dynamics in a CTTN-dependent manner. {ECO:0000250|UniProtKB:Q8SX68}.

Q9NW15

Main function of 5'-partner protein: FUNCTION: Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22946059}.
Ensembl transtripts involved in fusion geneENST idsENST00000527622, ENST00000301843, 
ENST00000346329, ENST00000376561, 
ENST00000538675, 		ENST00000355303, 
ENST00000316296, ENST00000398543, 
ENST00000530676, ENST00000538023, 
ENST00000525494, ENST00000531349, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score35 X 27 X 11=1039519 X 28 X 10=5320
# samples 4336
** MAII scorelog2(43/10395*10)=-4.59540928815627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(36/5320*10)=-3.88535743405888
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: CTTN [Title/Abstract] AND ANO1 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: CTTN [Title/Abstract] AND ANO1 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CTTN(70256066)-ANO1(69933858), # samples:2
Anticipated loss of major functional domain due to fusion event.CTTN-ANO1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CTTN-ANO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CTTN-ANO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CTTN-ANO1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
CTTN-ANO1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneANO1

GO:0006812

cation transport

22946059



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:70256066/chr11:69933858)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across CTTN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANO1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000346329CTTNchr1170256066+ENST00000355303ANO1chr1169933857+497659930834511047
ENST00000301843CTTNchr1170256066+ENST00000355303ANO1chr1169933857+487449720633491047
ENST00000376561CTTNchr1170256066+ENST00000355303ANO1chr1169933857+483946217133141047
ENST00000346329CTTNchr1170256066+ENST00000355303ANO1chr1169933858+497659930834511047
ENST00000301843CTTNchr1170256066+ENST00000355303ANO1chr1169933858+487449720633491047
ENST00000376561CTTNchr1170256066+ENST00000355303ANO1chr1169933858+483946217133141047
ENST00000346329CTTNchr1170275305+ENST00000355303ANO1chr1169970456+4961137330834361042
ENST00000346329CTTNchr1170275305+ENST00000398543ANO1chr1169970456+4870137330833461012
ENST00000346329CTTNchr1170275305+ENST00000538023ANO1chr1169970456+4960137330834361042
ENST00000346329CTTNchr1170275305+ENST00000316296ANO1chr1169970456+257313733082488726
ENST00000346329CTTNchr1170275305+ENST00000530676ANO1chr1169970456+3624137330833461012
ENST00000346329CTTNchr1170275305+ENST00000531349ANO1chr1169970456+4607137330833581016
ENST00000301843CTTNchr1170275305+ENST00000355303ANO1chr1169970456+4970138220634451079
ENST00000301843CTTNchr1170275305+ENST00000398543ANO1chr1169970456+4879138220633551049
ENST00000301843CTTNchr1170275305+ENST00000538023ANO1chr1169970456+4969138220634451079
ENST00000301843CTTNchr1170275305+ENST00000316296ANO1chr1169970456+258213822062497763
ENST00000301843CTTNchr1170275305+ENST00000530676ANO1chr1169970456+3633138220633551049
ENST00000301843CTTNchr1170275305+ENST00000531349ANO1chr1169970456+4616138220633671053
ENST00000376561CTTNchr1170275305+ENST00000355303ANO1chr1169970456+4824123617132991042
ENST00000376561CTTNchr1170275305+ENST00000398543ANO1chr1169970456+4733123617132091012
ENST00000376561CTTNchr1170275305+ENST00000538023ANO1chr1169970456+4823123617132991042
ENST00000376561CTTNchr1170275305+ENST00000316296ANO1chr1169970456+243612361712351726
ENST00000376561CTTNchr1170275305+ENST00000530676ANO1chr1169970456+3487123617132091012
ENST00000376561CTTNchr1170275305+ENST00000531349ANO1chr1169970456+4470123617132211016
ENST00000538675CTTNchr1170275305+ENST00000355303ANO1chr1169970456+39643761482439763
ENST00000538675CTTNchr1170275305+ENST00000398543ANO1chr1169970456+38733761482349733
ENST00000538675CTTNchr1170275305+ENST00000538023ANO1chr1169970456+39633761482439763
ENST00000538675CTTNchr1170275305+ENST00000316296ANO1chr1169970456+15763761481491447
ENST00000538675CTTNchr1170275305+ENST00000530676ANO1chr1169970456+26273761482349733
ENST00000538675CTTNchr1170275305+ENST00000531349ANO1chr1169970456+36103761482361737
ENST00000346329CTTNchr1170256065+ENST00000355303ANO1chr1169933857+497659930834511047
ENST00000301843CTTNchr1170256065+ENST00000355303ANO1chr1169933857+487449720633491047
ENST00000376561CTTNchr1170256065+ENST00000355303ANO1chr1169933857+483946217133141047

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000346329ENST00000355303CTTNchr1170256066+ANO1chr1169933857+0.0010484660.99895155
ENST00000301843ENST00000355303CTTNchr1170256066+ANO1chr1169933857+0.0009425070.9990575
ENST00000376561ENST00000355303CTTNchr1170256066+ANO1chr1169933857+0.0008666670.9991334
ENST00000346329ENST00000355303CTTNchr1170256066+ANO1chr1169933858+0.0010484660.99895155
ENST00000301843ENST00000355303CTTNchr1170256066+ANO1chr1169933858+0.0009425070.9990575
ENST00000376561ENST00000355303CTTNchr1170256066+ANO1chr1169933858+0.0008666670.9991334
ENST00000346329ENST00000355303CTTNchr1170275305+ANO1chr1169970456+0.0012239120.998776
ENST00000346329ENST00000398543CTTNchr1170275305+ANO1chr1169970456+0.0006352940.9993647
ENST00000346329ENST00000538023CTTNchr1170275305+ANO1chr1169970456+0.0012187060.99878126
ENST00000346329ENST00000316296CTTNchr1170275305+ANO1chr1169970456+0.0024766310.99752337
ENST00000346329ENST00000530676CTTNchr1170275305+ANO1chr1169970456+0.0021983120.9978017
ENST00000346329ENST00000531349CTTNchr1170275305+ANO1chr1169970456+0.0009714770.99902856
ENST00000301843ENST00000355303CTTNchr1170275305+ANO1chr1169970456+0.0012487350.9987513
ENST00000301843ENST00000398543CTTNchr1170275305+ANO1chr1169970456+0.0005711740.9994288
ENST00000301843ENST00000538023CTTNchr1170275305+ANO1chr1169970456+0.001242360.9987576
ENST00000301843ENST00000316296CTTNchr1170275305+ANO1chr1169970456+0.0023747190.9976253
ENST00000301843ENST00000530676CTTNchr1170275305+ANO1chr1169970456+0.0019753970.9980246
ENST00000301843ENST00000531349CTTNchr1170275305+ANO1chr1169970456+0.0008577260.9991423
ENST00000376561ENST00000355303CTTNchr1170275305+ANO1chr1169970456+0.0009856920.99901426
ENST00000376561ENST00000398543CTTNchr1170275305+ANO1chr1169970456+0.0005131620.9994868
ENST00000376561ENST00000538023CTTNchr1170275305+ANO1chr1169970456+0.0009820370.99901795
ENST00000376561ENST00000316296CTTNchr1170275305+ANO1chr1169970456+0.0021853110.99781466
ENST00000376561ENST00000530676CTTNchr1170275305+ANO1chr1169970456+0.0018784410.99812156
ENST00000376561ENST00000531349CTTNchr1170275305+ANO1chr1169970456+0.0007739240.9992261
ENST00000538675ENST00000355303CTTNchr1170275305+ANO1chr1169970456+0.0017027750.9982973
ENST00000538675ENST00000398543CTTNchr1170275305+ANO1chr1169970456+0.001524210.99847573
ENST00000538675ENST00000538023CTTNchr1170275305+ANO1chr1169970456+0.0016946240.9983053
ENST00000538675ENST00000316296CTTNchr1170275305+ANO1chr1169970456+0.0055316360.99446833
ENST00000538675ENST00000530676CTTNchr1170275305+ANO1chr1169970456+0.0079299440.99207
ENST00000538675ENST00000531349CTTNchr1170275305+ANO1chr1169970456+0.0029064690.99709356
ENST00000346329ENST00000355303CTTNchr1170256065+ANO1chr1169933857+0.0010484660.99895155
ENST00000301843ENST00000355303CTTNchr1170256065+ANO1chr1169933857+0.0009425070.9990575
ENST00000376561ENST00000355303CTTNchr1170256065+ANO1chr1169933857+0.0008666670.9991334

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for CTTN-ANO1

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
CTTNchr1170256065ANO1chr116993385746297GGKFGVEQDRMDKLLNSLSVDPDAEC
CTTNchr1170256065ANO1chr116993385749797GGKFGVEQDRMDKLLNSLSVDPDAEC
CTTNchr1170256065ANO1chr116993385759997GGKFGVEQDRMDKLLNSLSVDPDAEC
CTTNchr1170256066ANO1chr116993385746297GGKFGVEQDRMDKLLNSLSVDPDAEC
CTTNchr1170256066ANO1chr116993385749797GGKFGVEQDRMDKLLNSLSVDPDAEC
CTTNchr1170256066ANO1chr116993385759997GGKFGVEQDRMDKLLNSLSVDPDAEC
CTTNchr1170256066ANO1chr116993385846297GGKFGVEQDRMDKLLNSLSVDPDAEC
CTTNchr1170256066ANO1chr116993385849797GGKFGVEQDRMDKLLNSLSVDPDAEC
CTTNchr1170256066ANO1chr116993385859997GGKFGVEQDRMDKLLNSLSVDPDAEC
CTTNchr1170275305ANO1chr11699704561236355ERQEQEEARRKLELLYEEWARYGVFY
CTTNchr1170275305ANO1chr11699704561373355ERQEQEEARRKLELLYEEWARYGVFY
CTTNchr1170275305ANO1chr11699704561382392ERQEQEEARRKLELLYEEWARYGVFY
CTTNchr1170275305ANO1chr116997045637676ERQEQEEARRKLELLYEEWARYGVFY

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Potential FusionNeoAntigen Information of CTTN-ANO1 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
CTTN-ANO1_70256065_69933857.msa
CTTN-ANO1_70275305_69970456.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
CTTN-ANO1chr1170256065chr1169933857497HLA-A02:21RMDKLLNSL0.93970.5292918
CTTN-ANO1chr1170256065chr1169933857497HLA-A02:38RMDKLLNSL0.93810.6176918
CTTN-ANO1chr1170256065chr1169933857497HLA-A02:13RMDKLLNSL0.91150.5706918
CTTN-ANO1chr1170256065chr1169933857497HLA-B47:01VEQDRMDKL0.84880.5802514
CTTN-ANO1chr1170256065chr1169933857497HLA-B38:01EQDRMDKLL0.70620.9449615
CTTN-ANO1chr1170256065chr1169933857497HLA-B38:02EQDRMDKLL0.69650.9519615
CTTN-ANO1chr1170256065chr1169933857497HLA-A32:13RMDKLLNSL0.64360.8036918
CTTN-ANO1chr1170256065chr1169933857497HLA-B39:13RMDKLLNSL0.30220.8973918
CTTN-ANO1chr1170256065chr1169933857497HLA-B39:13VEQDRMDKL0.27260.9462514
CTTN-ANO1chr1170256065chr1169933857497HLA-B13:01RMDKLLNSL0.10440.689918
CTTN-ANO1chr1170256065chr1169933857497HLA-B39:01DRMDKLLNSL0.99890.8798818
CTTN-ANO1chr1170256065chr1169933857497HLA-B14:02DRMDKLLNSL0.99820.5695818
CTTN-ANO1chr1170256065chr1169933857497HLA-B14:01DRMDKLLNSL0.99820.5695818
CTTN-ANO1chr1170256065chr1169933857497HLA-B39:06DRMDKLLNSL0.99770.6351818
CTTN-ANO1chr1170256065chr1169933857497HLA-B38:02DRMDKLLNSL0.99750.9557818
CTTN-ANO1chr1170256065chr1169933857497HLA-B38:01DRMDKLLNSL0.99710.9469818
CTTN-ANO1chr1170256065chr1169933857497HLA-C04:10RMDKLLNSL0.99990.7224918
CTTN-ANO1chr1170256065chr1169933857497HLA-C05:09RMDKLLNSL0.99990.9159918
CTTN-ANO1chr1170256065chr1169933857497HLA-C04:07RMDKLLNSL0.99990.774918
CTTN-ANO1chr1170256065chr1169933857497HLA-C08:15RMDKLLNSL0.99970.9705918
CTTN-ANO1chr1170256065chr1169933857497HLA-C01:17RMDKLLNSL0.99940.9317918
CTTN-ANO1chr1170256065chr1169933857497HLA-C04:06RMDKLLNSL0.98660.7256918
CTTN-ANO1chr1170256065chr1169933857497HLA-B73:01DRMDKLLNS0.98190.5411817
CTTN-ANO1chr1170256065chr1169933857497HLA-C04:14RMDKLLNSL0.97710.6791918
CTTN-ANO1chr1170256065chr1169933857497HLA-C08:13RMDKLLNSL0.93520.9395918
CTTN-ANO1chr1170256065chr1169933857497HLA-C08:04RMDKLLNSL0.93520.9395918
CTTN-ANO1chr1170256065chr1169933857497HLA-B39:05EQDRMDKLL0.69120.8804615
CTTN-ANO1chr1170256065chr1169933857497HLA-C08:03RMDKLLNSL0.66770.9802918
CTTN-ANO1chr1170256065chr1169933857497HLA-B39:08EQDRMDKLL0.63690.865615
CTTN-ANO1chr1170256065chr1169933857497HLA-B39:08RMDKLLNSL0.6190.8729918
CTTN-ANO1chr1170256065chr1169933857497HLA-B39:08VEQDRMDKL0.50780.9364514
CTTN-ANO1chr1170256065chr1169933857497HLA-B39:09RMDKLLNSL0.45670.5339918
CTTN-ANO1chr1170256065chr1169933857497HLA-B14:03DKLLNSLSV0.36510.54061120
CTTN-ANO1chr1170256065chr1169933857497HLA-B39:12DRMDKLLNSL0.99840.8898818
CTTN-ANO1chr1170256065chr1169933857497HLA-B39:05DRMDKLLNSL0.9980.8623818
CTTN-ANO1chr1170256065chr1169933857497HLA-B14:03DRMDKLLNSL0.97550.7755818
CTTN-ANO1chr1170256065chr1169933857497HLA-C05:01RMDKLLNSL0.99990.9159918
CTTN-ANO1chr1170256065chr1169933857497HLA-C04:03RMDKLLNSL0.99990.8081918
CTTN-ANO1chr1170256065chr1169933857497HLA-C04:01RMDKLLNSL0.99990.774918
CTTN-ANO1chr1170256065chr1169933857497HLA-C18:01RMDKLLNSL0.99970.7831918
CTTN-ANO1chr1170256065chr1169933857497HLA-C08:02RMDKLLNSL0.99970.9705918
CTTN-ANO1chr1170256065chr1169933857497HLA-C01:03RMDKLLNSL0.99970.881918
CTTN-ANO1chr1170256065chr1169933857497HLA-C01:02RMDKLLNSL0.99950.9321918
CTTN-ANO1chr1170256065chr1169933857497HLA-B40:04VEQDRMDKL0.99820.7176514
CTTN-ANO1chr1170256065chr1169933857497HLA-C04:04RMDKLLNSL0.98410.6982918
CTTN-ANO1chr1170256065chr1169933857497HLA-A02:03RMDKLLNSL0.94440.5005918
CTTN-ANO1chr1170256065chr1169933857497HLA-A02:06RMDKLLNSL0.93970.5292918
CTTN-ANO1chr1170256065chr1169933857497HLA-C07:04RMDKLLNSL0.91690.9203918
CTTN-ANO1chr1170256065chr1169933857497HLA-A32:01RMDKLLNSL0.89920.8917918
CTTN-ANO1chr1170256065chr1169933857497HLA-C17:01RMDKLLNSL0.85720.7153918
CTTN-ANO1chr1170256065chr1169933857497HLA-B38:05EQDRMDKLL0.70620.9449615
CTTN-ANO1chr1170256065chr1169933857497HLA-C08:01RMDKLLNSL0.66770.9802918
CTTN-ANO1chr1170256065chr1169933857497HLA-B39:11EQDRMDKLL0.61130.8057615
CTTN-ANO1chr1170256065chr1169933857497HLA-B39:11RMDKLLNSL0.55850.7956918
CTTN-ANO1chr1170256065chr1169933857497HLA-B15:73RMDKLLNSL0.48860.7313918
CTTN-ANO1chr1170256065chr1169933857497HLA-B39:02RMDKLLNSL0.46040.8958918
CTTN-ANO1chr1170256065chr1169933857497HLA-B15:30RMDKLLNSL0.44060.7164918
CTTN-ANO1chr1170256065chr1169933857497HLA-B07:13RMDKLLNSL0.38850.8265918
CTTN-ANO1chr1170256065chr1169933857497HLA-B41:03VEQDRMDKL0.37880.6673514
CTTN-ANO1chr1170256065chr1169933857497HLA-B39:02VEQDRMDKL0.25820.942514
CTTN-ANO1chr1170256065chr1169933857497HLA-B39:31DRMDKLLNSL0.99910.8842818
CTTN-ANO1chr1170256065chr1169933857497HLA-B38:05DRMDKLLNSL0.99710.9469818
CTTN-ANO1chr1170275305chr11699704561382HLA-B27:02RRKLELLY0.99980.7672816
CTTN-ANO1chr1170275305chr11699704561382HLA-B27:04RRKLELLY0.99980.8482816
CTTN-ANO1chr1170275305chr11699704561382HLA-B27:02ARRKLELLY0.99750.8077716
CTTN-ANO1chr1170275305chr11699704561382HLA-B27:04ARRKLELLY0.99650.872716
CTTN-ANO1chr1170275305chr11699704561382HLA-B27:05ARRKLELLY0.99630.9408716
CTTN-ANO1chr1170275305chr11699704561382HLA-B14:02EEARRKLEL0.99210.5797514
CTTN-ANO1chr1170275305chr11699704561382HLA-B14:01EEARRKLEL0.99210.5797514
CTTN-ANO1chr1170275305chr11699704561382HLA-B58:01KLELLYEEW0.96880.9871019
CTTN-ANO1chr1170275305chr11699704561382HLA-B08:09EEARRKLEL0.96610.5493514
CTTN-ANO1chr1170275305chr11699704561382HLA-B44:03EEARRKLEL0.95760.9605514
CTTN-ANO1chr1170275305chr11699704561382HLA-A32:13KLELLYEEW0.95650.98271019
CTTN-ANO1chr1170275305chr11699704561382HLA-A68:05ELLYEEWAR0.95470.50731221
CTTN-ANO1chr1170275305chr11699704561382HLA-B18:01EEARRKLEL0.77170.8016514
CTTN-ANO1chr1170275305chr11699704561382HLA-B15:03ARRKLELLY0.14610.7863716
CTTN-ANO1chr1170275305chr11699704561382HLA-B27:02RRKLELLYEEW0.99990.6588819
CTTN-ANO1chr1170275305chr11699704561382HLA-B44:03EEARRKLELLY0.99950.9572516
CTTN-ANO1chr1170275305chr11699704561382HLA-B18:01EEARRKLELLY0.98070.6645516
CTTN-ANO1chr1170275305chr11699704561382HLA-B27:03RRKLELLY0.99710.9484816
CTTN-ANO1chr1170275305chr11699704561382HLA-B27:14ARRKLELLY0.99370.8958716
CTTN-ANO1chr1170275305chr11699704561382HLA-B27:03ARRKLELLY0.97140.9487716
CTTN-ANO1chr1170275305chr11699704561382HLA-C07:95ARRKLELLY0.9580.7229716
CTTN-ANO1chr1170275305chr11699704561382HLA-C07:27ARRKLELLY0.95490.9596716
CTTN-ANO1chr1170275305chr11699704561382HLA-C07:19ARRKLELLY0.89530.8022716
CTTN-ANO1chr1170275305chr11699704561382HLA-C07:46ARRKLELLY0.83920.9364716
CTTN-ANO1chr1170275305chr11699704561382HLA-C07:05ARRKLELLY0.8320.9657716
CTTN-ANO1chr1170275305chr11699704561382HLA-C07:80ARRKLELLY0.81810.9645716
CTTN-ANO1chr1170275305chr11699704561382HLA-C07:67ARRKLELLY0.81810.9645716
CTTN-ANO1chr1170275305chr11699704561382HLA-B14:03EEARRKLEL0.81170.8789514
CTTN-ANO1chr1170275305chr11699704561382HLA-C07:10ARRKLELLY0.79880.9793716
CTTN-ANO1chr1170275305chr11699704561382HLA-B39:12EEARRKLEL0.47410.8941514
CTTN-ANO1chr1170275305chr11699704561382HLA-C12:16ARRKLELLY0.02240.9658716
CTTN-ANO1chr1170275305chr11699704561382HLA-B27:10RRKLELLY0.99980.922816
CTTN-ANO1chr1170275305chr11699704561382HLA-B27:08ARRKLELLY0.99720.896716
CTTN-ANO1chr1170275305chr11699704561382HLA-B27:10ARRKLELLY0.99580.9309716
CTTN-ANO1chr1170275305chr11699704561382HLA-B40:04EEARRKLEL0.99120.6416514
CTTN-ANO1chr1170275305chr11699704561382HLA-A32:01KLELLYEEW0.98520.98881019
CTTN-ANO1chr1170275305chr11699704561382HLA-C07:01ARRKLELLY0.98230.7076716
CTTN-ANO1chr1170275305chr11699704561382HLA-B44:13EEARRKLEL0.95760.9605514
CTTN-ANO1chr1170275305chr11699704561382HLA-B44:07EEARRKLEL0.95760.9605514
CTTN-ANO1chr1170275305chr11699704561382HLA-B44:26EEARRKLEL0.95760.9605514
CTTN-ANO1chr1170275305chr11699704561382HLA-B57:04KLELLYEEW0.94280.89051019
CTTN-ANO1chr1170275305chr11699704561382HLA-B27:09ARRKLELLY0.90210.9285716
CTTN-ANO1chr1170275305chr11699704561382HLA-C07:17ARRKLELLY0.89060.9669716
CTTN-ANO1chr1170275305chr11699704561382HLA-C07:02ARRKLELLY0.81810.9645716
CTTN-ANO1chr1170275305chr11699704561382HLA-B08:12EEARRKLEL0.80050.5321514
CTTN-ANO1chr1170275305chr11699704561382HLA-B18:05EEARRKLEL0.77170.8016514
CTTN-ANO1chr1170275305chr11699704561382HLA-B57:02KLELLYEEW0.76190.9541019
CTTN-ANO1chr1170275305chr11699704561382HLA-B18:06EEARRKLEL0.74190.8065514
CTTN-ANO1chr1170275305chr11699704561382HLA-B18:08EEARRKLEL0.73440.7956514
CTTN-ANO1chr1170275305chr11699704561382HLA-B18:03EEARRKLEL0.70230.7951514
CTTN-ANO1chr1170275305chr11699704561382HLA-C07:22ARRKLELLY0.67020.7567716
CTTN-ANO1chr1170275305chr11699704561382HLA-B18:11EEARRKLEL0.62810.7688514
CTTN-ANO1chr1170275305chr11699704561382HLA-B39:31EEARRKLEL0.55310.8864514
CTTN-ANO1chr1170275305chr11699704561382HLA-B39:02EEARRKLEL0.5250.8918514
CTTN-ANO1chr1170275305chr11699704561382HLA-C06:08ARRKLELLY0.23920.9887716
CTTN-ANO1chr1170275305chr11699704561382HLA-B15:54ARRKLELLY0.0270.8975716
CTTN-ANO1chr1170275305chr11699704561382HLA-B15:68ARRKLELLY0.0250.7988716
CTTN-ANO1chr1170275305chr11699704561382HLA-C06:17ARRKLELLY0.01110.9909716
CTTN-ANO1chr1170275305chr11699704561382HLA-C06:02ARRKLELLY0.01110.9909716
CTTN-ANO1chr1170275305chr11699704561382HLA-B44:13EEARRKLELLY0.99950.9572516
CTTN-ANO1chr1170275305chr11699704561382HLA-B44:07EEARRKLELLY0.99950.9572516
CTTN-ANO1chr1170275305chr11699704561382HLA-B44:26EEARRKLELLY0.99950.9572516
CTTN-ANO1chr1170275305chr11699704561382HLA-B18:05EEARRKLELLY0.98070.6645516
CTTN-ANO1chr1170275305chr11699704561382HLA-B18:11EEARRKLELLY0.9460.5916516

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Potential FusionNeoAntigen Information of CTTN-ANO1 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
CTTN-ANO1_70256065_69933857.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
CTTN-ANO1chr1170256065chr1169933857497DRB1-0409GGKFGVEQDRMDKLL015

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Fusion breakpoint peptide structures of CTTN-ANO1

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
1547EARRKLELLYEEWACTTNANO1chr1170275305chr11699704561382
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
2036EQDRMDKLLNSLSVCTTNANO1chr1170256065chr1169933857497

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of CTTN-ANO1

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN1547EARRKLELLYEEWA-7.9962-8.1096
HLA-B14:023BVN1547EARRKLELLYEEWA-5.70842-6.74372
HLA-B52:013W391547EARRKLELLYEEWA-6.83737-6.95077
HLA-B52:013W391547EARRKLELLYEEWA-4.4836-5.5189
HLA-A11:014UQ21547EARRKLELLYEEWA-10.0067-10.1201
HLA-A11:014UQ21547EARRKLELLYEEWA-9.03915-10.0745
HLA-A24:025HGA1547EARRKLELLYEEWA-6.56204-6.67544
HLA-A24:025HGA1547EARRKLELLYEEWA-5.42271-6.45801
HLA-B44:053DX81547EARRKLELLYEEWA-7.85648-8.89178
HLA-B44:053DX81547EARRKLELLYEEWA-5.3978-5.5112
HLA-A02:016TDR1547EARRKLELLYEEWA-3.37154-4.40684
HLA-B14:023BVN2036EQDRMDKLLNSLSV-7.9962-8.1096
HLA-B14:023BVN2036EQDRMDKLLNSLSV-5.70842-6.74372
HLA-B52:013W392036EQDRMDKLLNSLSV-6.83737-6.95077
HLA-B52:013W392036EQDRMDKLLNSLSV-4.4836-5.5189
HLA-A11:014UQ22036EQDRMDKLLNSLSV-10.0067-10.1201
HLA-A11:014UQ22036EQDRMDKLLNSLSV-9.03915-10.0745
HLA-A24:025HGA2036EQDRMDKLLNSLSV-6.56204-6.67544
HLA-A24:025HGA2036EQDRMDKLLNSLSV-5.42271-6.45801
HLA-B44:053DX82036EQDRMDKLLNSLSV-7.85648-8.89178
HLA-B44:053DX82036EQDRMDKLLNSLSV-5.3978-5.5112
HLA-A02:016TDR2036EQDRMDKLLNSLSV-3.37154-4.40684

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Vaccine Design for the FusionNeoAntigens of CTTN-ANO1

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
CTTN-ANO1chr1170256065chr11699338571120DKLLNSLSVGATAAGCTGCTGAACTCCTTATCTGTG
CTTN-ANO1chr1170256065chr1169933857514VEQDRMDKLGTGGAACAAGACCGAATGGATAAGCTG
CTTN-ANO1chr1170256065chr1169933857615EQDRMDKLLGAACAAGACCGAATGGATAAGCTGCTG
CTTN-ANO1chr1170256065chr1169933857817DRMDKLLNSGACCGAATGGATAAGCTGCTGAACTCC
CTTN-ANO1chr1170256065chr1169933857818DRMDKLLNSLGACCGAATGGATAAGCTGCTGAACTCCTTA
CTTN-ANO1chr1170256065chr1169933857918RMDKLLNSLCGAATGGATAAGCTGCTGAACTCCTTA
CTTN-ANO1chr1170275305chr11699704561019KLELLYEEWAAGCTGGAGCTCCTGTACGAAGAGTGG
CTTN-ANO1chr1170275305chr11699704561221ELLYEEWARGAGCTCCTGTACGAAGAGTGGGCACGC
CTTN-ANO1chr1170275305chr1169970456514EEARRKLELGAAGAGGCCAGGAGGAAGCTGGAGCTC
CTTN-ANO1chr1170275305chr1169970456516EEARRKLELLYGAAGAGGCCAGGAGGAAGCTGGAGCTCCTGTAC
CTTN-ANO1chr1170275305chr1169970456716ARRKLELLYGCCAGGAGGAAGCTGGAGCTCCTGTAC
CTTN-ANO1chr1170275305chr1169970456816RRKLELLYAGGAGGAAGCTGGAGCTCCTGTAC
CTTN-ANO1chr1170275305chr1169970456819RRKLELLYEEWAGGAGGAAGCTGGAGCTCCTGTACGAAGAGTGG

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
CTTN-ANO1chr1170256065chr1169933857015GGKFGVEQDRMDKLLGGAGGGAAATTTGGTGTGGAACAAGACCGAATGGATAAGCTGCTG

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Information of the samples that have these potential fusion neoantigens of CTTN-ANO1

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
UCECCTTN-ANO1chr1170275305ENST00000301843chr1169970456ENST00000316296TCGA-D1-A162-01A
BRCACTTN-ANO1chr1170256065ENST00000301843chr1169933857ENST00000355303TCGA-A8-A07O-01A

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Potential target of CAR-T therapy development for CTTN-ANO1

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANO1chr11:70256065chr11:69933857ENST00000316296017334_3540643.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000316296017407_4270643.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000316296017520_5400643.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000316296017569_5890643.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000316296017608_6280643.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000316296017658_6780643.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000316296017726_7460643.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000316296017747_7670643.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000316296017785_8050643.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000316296017893_9130643.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000355303026334_3540987.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000355303026407_4270987.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000355303026520_5400987.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000355303026569_5890987.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000355303026608_6280987.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000355303026658_6780987.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000355303026726_7460987.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000355303026747_7670987.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000355303026785_8050987.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000355303026893_9130987.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000398543024334_3540841.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000398543024407_4270841.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000398543024520_5400841.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000398543024569_5890841.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000398543024608_6280841.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000398543024658_6780841.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000398543024726_7460841.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000398543024747_7670841.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000398543024785_8050841.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000398543024893_9130841.0TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000530676025334_3540819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000530676025407_4270819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000530676025520_5400819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000530676025569_5890819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000530676025608_6280819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000530676025658_6780819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000530676025726_7460819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000530676025747_7670819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000530676025785_8050819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256065chr11:69933857ENST00000530676025893_9130819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000316296017334_3540643.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000316296017407_4270643.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000316296017520_5400643.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000316296017569_5890643.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000316296017608_6280643.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000316296017658_6780643.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000316296017726_7460643.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000316296017747_7670643.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000316296017785_8050643.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000316296017893_9130643.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000355303026334_3540987.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000355303026407_4270987.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000355303026520_5400987.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000355303026569_5890987.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000355303026608_6280987.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000355303026658_6780987.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000355303026726_7460987.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000355303026747_7670987.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000355303026785_8050987.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000355303026893_9130987.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000398543024334_3540841.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000398543024407_4270841.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000398543024520_5400841.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000398543024569_5890841.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000398543024608_6280841.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000398543024658_6780841.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000398543024726_7460841.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000398543024747_7670841.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000398543024785_8050841.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000398543024893_9130841.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000530676025334_3540819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000530676025407_4270819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000530676025520_5400819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000530676025569_5890819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000530676025608_6280819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000530676025658_6780819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000530676025726_7460819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000530676025747_7670819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000530676025785_8050819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933857ENST00000530676025893_9130819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000316296017334_3540643.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000316296017407_4270643.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000316296017520_5400643.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000316296017569_5890643.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000316296017608_6280643.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000316296017658_6780643.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000316296017726_7460643.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000316296017747_7670643.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000316296017785_8050643.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000316296017893_9130643.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000355303026334_3540987.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000355303026407_4270987.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000355303026520_5400987.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000355303026569_5890987.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000355303026608_6280987.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000355303026658_6780987.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000355303026726_7460987.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000355303026747_7670987.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000355303026785_8050987.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000355303026893_9130987.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000398543024334_3540841.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000398543024407_4270841.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000398543024520_5400841.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000398543024569_5890841.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000398543024608_6280841.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000398543024658_6780841.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000398543024726_7460841.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000398543024747_7670841.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000398543024785_8050841.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000398543024893_9130841.0TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000530676025334_3540819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000530676025407_4270819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000530676025520_5400819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000530676025569_5890819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000530676025608_6280819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000530676025658_6780819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000530676025726_7460819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000530676025747_7670819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000530676025785_8050819.3333333333334TransmembraneHelical
TgeneANO1chr11:70256066chr11:69933858ENST00000530676025893_9130819.3333333333334TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000316296717334_3540643.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000316296717407_4270643.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000316296717520_5400643.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000316296717569_5890643.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000316296717608_6280643.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000316296717658_6780643.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000316296717726_7460643.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000316296717747_7670643.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000316296717785_8050643.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000316296717893_9130643.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000355303726334_3540987.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000355303726407_4270987.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000355303726520_5400987.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000355303726569_5890987.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000355303726608_6280987.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000355303726658_6780987.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000355303726726_7460987.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000355303726747_7670987.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000355303726785_8050987.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000355303726893_9130987.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000398543724334_3540841.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000398543724407_4270841.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000398543724520_5400841.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000398543724569_5890841.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000398543724608_6280841.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000398543724658_6780841.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000398543724726_7460841.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000398543724747_7670841.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000398543724785_8050841.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000398543724893_9130841.0TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000530676725334_3540819.3333333333334TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000530676725407_4270819.3333333333334TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000530676725520_5400819.3333333333334TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000530676725569_5890819.3333333333334TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000530676725608_6280819.3333333333334TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000530676725658_6780819.3333333333334TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000530676725726_7460819.3333333333334TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000530676725747_7670819.3333333333334TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000530676725785_8050819.3333333333334TransmembraneHelical
TgeneANO1chr11:70275305chr11:69970456ENST00000530676725893_9130819.3333333333334TransmembraneHelical

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to CTTN-ANO1

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CTTN-ANO1

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource