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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:DDR1-MRPS18B

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DDR1-MRPS18B
FusionPDB ID: 21844
FusionGDB2.0 ID: 21844
HgeneTgene
Gene symbol

DDR1

MRPS18B

Gene ID

780

28973

Gene namediscoidin domain receptor tyrosine kinase 1mitochondrial ribosomal protein S18B
SynonymsCAK|CD167|DDR|EDDR1|HGK2|MCK10|NEP|NTRK4|PTK3|PTK3A|RTK6|TRKEC6orf14|HSPC183|HumanS18a|MRP-S18-2|MRPS18-2|PTD017|S18amt
Cytomap

6p21.33

6p21.33

Type of geneprotein-codingprotein-coding
Descriptionepithelial discoidin domain-containing receptor 1CD167 antigen-like family member APTK3A protein tyrosine kinase 3Acell adhesion kinasemammary carcinoma kinase 10neuroepithelial tyrosine kinaseneurotrophic tyrosine kinase, receptor, type 4protein-t28S ribosomal protein S18b, mitochondrial28S ribosomal protein S18-2, mitochondrialMRP-S18-bS18mt-bmitochondrial ribosomal protein S18-2mitochondrial small ribosomal subunit protein bS18bmitochondrial small ribosomal subunit protein bS18m-Bmitochon
Modification date2020032920200320
UniProtAcc

Q08345

Main function of 5'-partner protein: FUNCTION: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. {ECO:0000250, ECO:0000269|PubMed:12065315, ECO:0000269|PubMed:16234985, ECO:0000269|PubMed:16337946, ECO:0000269|PubMed:19401332, ECO:0000269|PubMed:20093046, ECO:0000269|PubMed:20432435, ECO:0000269|PubMed:20884741, ECO:0000269|PubMed:21044884, ECO:0000269|PubMed:9659899}.

Q9Y676

Main function of 5'-partner protein:
Ensembl transtripts involved in fusion geneENST idsENST00000446312, ENST00000508472, 
ENST00000324771, ENST00000361741, 
ENST00000376567, ENST00000376568, 
ENST00000376569, ENST00000376570, 
ENST00000376575, ENST00000418800, 
ENST00000452441, ENST00000454612, 
ENST00000508312, ENST00000513240, 
ENST00000259875, ENST00000383377, 
ENST00000400410, ENST00000400411, 
ENST00000400414, ENST00000400486, 
ENST00000400488, ENST00000400489, 
ENST00000400491, ENST00000400492, 
ENST00000412329, ENST00000415092, 
ENST00000419412, ENST00000421229, 
ENST00000422628, ENST00000427053, 
ENST00000429699, ENST00000430933, 
ENST00000434428, ENST00000449518, 
ENST00000453510, ENST00000454774, 
ENST00000462241, ENST00000468225, 
ENST00000483193, ENST00000487780, 
ENST00000488414, ENST00000490712, 
ENST00000548133, ENST00000548693, 
ENST00000548962, ENST00000549026, 
ENST00000550384, ENST00000550395, 
ENST00000550666, ENST00000552068, 
ENST00000552434, ENST00000552721, 
ENST00000553015, 		ENST00000259873, 
ENST00000506373, ENST00000472229, 
ENST00000327800, ENST00000400594, 
ENST00000412451, ENST00000412843, 
ENST00000418070, ENST00000426945, 
ENST00000428224, ENST00000430402, 
ENST00000437247, ENST00000440992, 
ENST00000451032, ENST00000454427, 
ENST00000468755, ENST00000469397, 
ENST00000472444, ENST00000477010, 
ENST00000489289, ENST00000493769, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 6 X 4=1445 X 9 X 4=180
# samples 67
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: DDR1 [Title/Abstract] AND MRPS18B [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: DDR1 [Title/Abstract] AND MRPS18B [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DDR1(30859965)-MRPS18B(30587270), # samples:1
Anticipated loss of major functional domain due to fusion event.DDR1-MRPS18B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DDR1-MRPS18B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDDR1

GO:0038063

collagen-activated tyrosine kinase receptor signaling pathway

9659899|21044884

HgeneDDR1

GO:0038083

peptidyl-tyrosine autophosphorylation

21044884

HgeneDDR1

GO:0046777

protein autophosphorylation

9659899



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:30859965/chr6:30587270)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across DDR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MRPS18B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000324771DDR1chr630859965+ENST00000259873MRPS18Bchr630587270+269714005482098516
ENST00000324771DDR1chr630859965+ENST00000506373MRPS18Bchr630587270+251614005481687379
ENST00000418800DDR1chr630859965+ENST00000259873MRPS18Bchr630587270+256212653531963536
ENST00000418800DDR1chr630859965+ENST00000506373MRPS18Bchr630587270+238112653531552399
ENST00000454612DDR1chr630859965+ENST00000259873MRPS18Bchr630587270+260013034512001516
ENST00000454612DDR1chr630859965+ENST00000506373MRPS18Bchr630587270+241913034511590379
ENST00000376569DDR1chr630859965+ENST00000259873MRPS18Bchr630587270+244111442921842516
ENST00000376569DDR1chr630859965+ENST00000506373MRPS18Bchr630587270+226011442921431379
ENST00000376575DDR1chr630859965+ENST00000259873MRPS18Bchr630587270+248211853331883516
ENST00000376575DDR1chr630859965+ENST00000506373MRPS18Bchr630587270+230111853331472379
ENST00000376570DDR1chr630859965+ENST00000259873MRPS18Bchr630587270+248211853331883516
ENST00000376570DDR1chr630859965+ENST00000506373MRPS18Bchr630587270+230111853331472379
ENST00000376568DDR1chr630859965+ENST00000259873MRPS18Bchr630587270+244411472951845516
ENST00000376568DDR1chr630859965+ENST00000506373MRPS18Bchr630587270+226311472951434379
ENST00000452441DDR1chr630859965+ENST00000259873MRPS18Bchr630587270+240811112591809516
ENST00000452441DDR1chr630859965+ENST00000506373MRPS18Bchr630587270+222711112591398379
ENST00000508312DDR1chr630859965+ENST00000259873MRPS18Bchr630587270+245511582521856534
ENST00000508312DDR1chr630859965+ENST00000506373MRPS18Bchr630587270+227411582521445397
ENST00000376567DDR1chr630859965+ENST00000259873MRPS18Bchr630587270+249011932931891532
ENST00000376567DDR1chr630859965+ENST00000506373MRPS18Bchr630587270+230911932931480395
ENST00000513240DDR1chr630859965+ENST00000259873MRPS18Bchr630587270+214985201550516
ENST00000513240DDR1chr630859965+ENST00000506373MRPS18Bchr630587270+196885201139379
ENST00000361741DDR1chr630859965+ENST00000259873MRPS18Bchr630587270+153724054938294
ENST00000361741DDR1chr630859965+ENST00000506373MRPS18Bchr630587270+135624054527157

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000324771ENST00000259873DDR1chr630859965+MRPS18Bchr630587270+0.0146515270.9853485
ENST00000324771ENST00000506373DDR1chr630859965+MRPS18Bchr630587270+0.0050121530.99498785
ENST00000418800ENST00000259873DDR1chr630859965+MRPS18Bchr630587270+0.0094220770.99057794
ENST00000418800ENST00000506373DDR1chr630859965+MRPS18Bchr630587270+0.003646760.99635327
ENST00000454612ENST00000259873DDR1chr630859965+MRPS18Bchr630587270+0.0119992250.9880008
ENST00000454612ENST00000506373DDR1chr630859965+MRPS18Bchr630587270+0.003962240.9960377
ENST00000376569ENST00000259873DDR1chr630859965+MRPS18Bchr630587270+0.0119653090.98803467
ENST00000376569ENST00000506373DDR1chr630859965+MRPS18Bchr630587270+0.004101750.9958982
ENST00000376575ENST00000259873DDR1chr630859965+MRPS18Bchr630587270+0.0129063060.9870936
ENST00000376575ENST00000506373DDR1chr630859965+MRPS18Bchr630587270+0.004289860.99571013
ENST00000376570ENST00000259873DDR1chr630859965+MRPS18Bchr630587270+0.0129063060.9870936
ENST00000376570ENST00000506373DDR1chr630859965+MRPS18Bchr630587270+0.004289860.99571013
ENST00000376568ENST00000259873DDR1chr630859965+MRPS18Bchr630587270+0.0125607780.9874392
ENST00000376568ENST00000506373DDR1chr630859965+MRPS18Bchr630587270+0.0041165330.9958834
ENST00000452441ENST00000259873DDR1chr630859965+MRPS18Bchr630587270+0.0129909010.9870091
ENST00000452441ENST00000506373DDR1chr630859965+MRPS18Bchr630587270+0.0039641490.9960359
ENST00000508312ENST00000259873DDR1chr630859965+MRPS18Bchr630587270+0.0150574380.98494256
ENST00000508312ENST00000506373DDR1chr630859965+MRPS18Bchr630587270+0.0132510240.986749
ENST00000376567ENST00000259873DDR1chr630859965+MRPS18Bchr630587270+0.0043606840.9956393
ENST00000376567ENST00000506373DDR1chr630859965+MRPS18Bchr630587270+0.0015347720.9984653
ENST00000513240ENST00000259873DDR1chr630859965+MRPS18Bchr630587270+0.0079943380.99200565
ENST00000513240ENST00000506373DDR1chr630859965+MRPS18Bchr630587270+0.0025851340.9974148
ENST00000361741ENST00000259873DDR1chr630859965+MRPS18Bchr630587270+0.0065674840.9934325
ENST00000361741ENST00000506373DDR1chr630859965+MRPS18Bchr630587270+0.0581666530.9418333

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for DDR1-MRPS18B

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
DDR1chr630859965MRPS18Bchr6305872701111284FEFDRLRAFQAMQVPLQTLCTKAPSE
DDR1chr630859965MRPS18Bchr6305872701144284FEFDRLRAFQAMQVPLQTLCTKAPSE
DDR1chr630859965MRPS18Bchr6305872701147284FEFDRLRAFQAMQVPLQTLCTKAPSE
DDR1chr630859965MRPS18Bchr6305872701158302FEFDRLRAFQAMQVPLQTLCTKAPSE
DDR1chr630859965MRPS18Bchr6305872701185284FEFDRLRAFQAMQVPLQTLCTKAPSE
DDR1chr630859965MRPS18Bchr6305872701193300FEFDRLRAFQAMQVPLQTLCTKAPSE
DDR1chr630859965MRPS18Bchr6305872701265304FEFDRLRAFQAMQVPLQTLCTKAPSE
DDR1chr630859965MRPS18Bchr6305872701303284FEFDRLRAFQAMQVPLQTLCTKAPSE
DDR1chr630859965MRPS18Bchr6305872701400284FEFDRLRAFQAMQVPLQTLCTKAPSE
DDR1chr630859965MRPS18Bchr63058727024062FEFDRLRAFQAMQVPLQTLCTKAPSE
DDR1chr630859965MRPS18Bchr630587270852284FEFDRLRAFQAMQVPLQTLCTKAPSE

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Potential FusionNeoAntigen Information of DDR1-MRPS18B in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
DDR1-MRPS18B_30859965_30587270.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B48:01MQVPLQTL0.99840.75791119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B39:24MQVPLQTL0.99650.84831119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B39:01MQVPLQTL0.9880.99261119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B39:13MQVPLQTL0.98150.99661119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B15:10MQVPLQTL0.96970.88921119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B13:02MQVPLQTL0.96920.95311119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B15:03MQVPLQTL0.96410.94041119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B13:01MQVPLQTL0.9560.99691119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B15:37MQVPLQTL0.86690.87661119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B52:01RAFQAMQV0.86070.9681614
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B52:01MQVPLQTL0.8290.99331119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B39:06LRAFQAMQV0.99620.9677514
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A02:22AMQVPLQTL0.92530.86531019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A02:38AMQVPLQTL0.86570.83491019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A02:13AMQVPLQTL0.84310.87481019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A02:27AMQVPLQTL0.81970.82921019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A02:30AMQVPLQTL0.81490.83971019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A02:24AMQVPLQTL0.81490.83971019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A02:67AMQVPLQTL0.81490.83971019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A02:60AMQVPLQTL0.81430.85031019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A02:11AMQVPLQTL0.80020.84221019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A02:04AMQVPLQTL0.76820.94851019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A02:17AMQVPLQTL0.76360.94221019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A02:35AMQVPLQTL0.71380.82911019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A02:16AMQVPLQTL0.68520.72431019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A02:29AMQVPLQTL0.67410.83571019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A02:20AMQVPLQTL0.6730.84331019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B48:01AMQVPLQTL0.56890.94521019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A02:19AMQVPLQTL0.52250.78081019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A32:13AMQVPLQTL0.48140.98981019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B07:10AMQVPLQTL0.17970.64081019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B13:02AMQVPLQTL0.15090.98311019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B13:01AMQVPLQTL0.1230.99841019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B39:09MQVPLQTL0.99490.95671119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B15:04MQVPLQTL0.99090.96451119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B48:03MQVPLQTL0.9860.68891119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B39:08MQVPLQTL0.97870.98921119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B39:05MQVPLQTL0.97750.99141119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B14:03MQVPLQTL0.92140.94621119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B51:07MQVPLQTL0.68570.98041119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B73:01LRAFQAMQV0.99380.95514
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B15:04AMQVPLQTL0.94740.98061019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A02:02AMQVPLQTL0.93250.8831019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A02:05AMQVPLQTL0.92690.92491019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-C01:17AMQVPLQTL0.89210.991019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A02:07AMQVPLQTL0.82310.85331019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A02:01AMQVPLQTL0.81490.83971019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-C01:30AMQVPLQTL0.72120.98561019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B48:03AMQVPLQTL0.12730.91151019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-C03:08QAMQVPLQTL0.99920.9682919
DDR1-MRPS18Bchr630859965chr6305872701400HLA-C15:02RAFQAMQV0.99890.9336614
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B15:73MQVPLQTL0.98820.99511119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B40:12MQVPLQTL0.9860.68891119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B39:31MQVPLQTL0.98020.99251119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B15:30MQVPLQTL0.98020.99171119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B39:11MQVPLQTL0.97870.98121119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B39:02MQVPLQTL0.97850.99651119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B40:49MQVPLQTL0.96320.56951119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B40:21MQVPLQTL0.93520.72681119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B48:02MQVPLQTL0.85370.98721119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B15:09MQVPLQTL0.84950.96291119
DDR1-MRPS18Bchr630859965chr6305872701400HLA-C06:08LRAFQAMQV0.97180.9962514
DDR1-MRPS18Bchr630859965chr6305872701400HLA-C01:03AMQVPLQTL0.94940.98681019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B15:73AMQVPLQTL0.94130.99681019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-C01:02AMQVPLQTL0.93260.98941019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A02:03AMQVPLQTL0.92880.90991019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B15:24AMQVPLQTL0.92730.97141019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B15:30AMQVPLQTL0.90810.99411019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A02:14AMQVPLQTL0.81350.89771019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-A32:01AMQVPLQTL0.72630.99531019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-C07:22LRAFQAMQV0.70530.8921514
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B39:02AMQVPLQTL0.42880.99671019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B48:05AMQVPLQTL0.26640.5481019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B07:13AMQVPLQTL0.26270.891019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-C14:03AFQAMQVPL0.13840.9835716
DDR1-MRPS18Bchr630859965chr6305872701400HLA-C14:02AFQAMQVPL0.13840.9835716
DDR1-MRPS18Bchr630859965chr6305872701400HLA-C06:17LRAFQAMQV0.13560.997514
DDR1-MRPS18Bchr630859965chr6305872701400HLA-C06:02LRAFQAMQV0.13560.997514
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B40:12AMQVPLQTL0.12730.91151019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B40:21AMQVPLQTL0.09660.92371019
DDR1-MRPS18Bchr630859965chr6305872701400HLA-C03:04QAMQVPLQTL0.99920.9937919
DDR1-MRPS18Bchr630859965chr6305872701400HLA-C03:03QAMQVPLQTL0.99920.9937919
DDR1-MRPS18Bchr630859965chr6305872701400HLA-C03:05QAMQVPLQTL0.99850.9717919
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B35:13QAMQVPLQTL0.88320.9686919
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B15:30FQAMQVPLQTL0.99590.9964819
DDR1-MRPS18Bchr630859965chr6305872701400HLA-B40:21FQAMQVPLQTL0.94260.8996819

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Potential FusionNeoAntigen Information of DDR1-MRPS18B in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
DDR1-MRPS18B_30859965_30587270.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-0443RLRAFQAMQVPLQTL419
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1501FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1504FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1505FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1506FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1507FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1509FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1510FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1512FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1513FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1516FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1518FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1520FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1521FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1521EFDRLRAFQAMQVPL116
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1521DRLRAFQAMQVPLQT318
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1521FEFDRLRAFQAMQVP015
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1522FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1524FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1528FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1529FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1532FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1533FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1535FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1536FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1537FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1540FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1541FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1542FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1543FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1545FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1546FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1548FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1549FDRLRAFQAMQVPLQ217
DDR1-MRPS18Bchr630859965chr6305872701400DRB1-1615FDRLRAFQAMQVPLQ217

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Fusion breakpoint peptide structures of DDR1-MRPS18B

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
7679RAFQAMQVPLQTLCDDR1MRPS18Bchr630859965chr6305872701400

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of DDR1-MRPS18B

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B52:013W397679RAFQAMQVPLQTLC-7.90165-7.90165
HLA-B44:053DX87679RAFQAMQVPLQTLC-5.81679-5.81679

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Vaccine Design for the FusionNeoAntigens of DDR1-MRPS18B

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
DDR1-MRPS18Bchr630859965chr6305872701019AMQVPLQTLGCTATGCAGGTTCCCCTCCAGACTCTT
DDR1-MRPS18Bchr630859965chr6305872701119MQVPLQTLATGCAGGTTCCCCTCCAGACTCTT
DDR1-MRPS18Bchr630859965chr630587270514LRAFQAMQVCTGAGGGCCTTCCAGGCTATGCAGGTT
DDR1-MRPS18Bchr630859965chr630587270614RAFQAMQVAGGGCCTTCCAGGCTATGCAGGTT
DDR1-MRPS18Bchr630859965chr630587270716AFQAMQVPLGCCTTCCAGGCTATGCAGGTTCCCCTC
DDR1-MRPS18Bchr630859965chr630587270819FQAMQVPLQTLTTCCAGGCTATGCAGGTTCCCCTCCAGACTCTT
DDR1-MRPS18Bchr630859965chr630587270919QAMQVPLQTLCAGGCTATGCAGGTTCCCCTCCAGACTCTT

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
DDR1-MRPS18Bchr630859965chr630587270015FEFDRLRAFQAMQVPTTTGAGTTTGACCGGCTGAGGGCCTTCCAGGCTATGCAGGTTCCC
DDR1-MRPS18Bchr630859965chr630587270116EFDRLRAFQAMQVPLGAGTTTGACCGGCTGAGGGCCTTCCAGGCTATGCAGGTTCCCCTC
DDR1-MRPS18Bchr630859965chr630587270217FDRLRAFQAMQVPLQTTTGACCGGCTGAGGGCCTTCCAGGCTATGCAGGTTCCCCTCCAG
DDR1-MRPS18Bchr630859965chr630587270318DRLRAFQAMQVPLQTGACCGGCTGAGGGCCTTCCAGGCTATGCAGGTTCCCCTCCAGACT
DDR1-MRPS18Bchr630859965chr630587270419RLRAFQAMQVPLQTLCGGCTGAGGGCCTTCCAGGCTATGCAGGTTCCCCTCCAGACTCTT

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Information of the samples that have these potential fusion neoantigens of DDR1-MRPS18B

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
BRCADDR1-MRPS18Bchr630859965ENST00000324771chr630587270ENST00000259873TCGA-A8-A092-01A

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Potential target of CAR-T therapy development for DDR1-MRPS18B

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to DDR1-MRPS18B

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DDR1-MRPS18B

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource