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Fusion Protein:DDR1-PAK1 |
Fusion Gene and Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: DDR1-PAK1 | FusionPDB ID: 21845 | FusionGDB2.0 ID: 21845 | Hgene | Tgene | Gene symbol | DDR1 | PAK1 | Gene ID | 780 | 5585 |
Gene name | discoidin domain receptor tyrosine kinase 1 | protein kinase N1 | |
Synonyms | CAK|CD167|DDR|EDDR1|HGK2|MCK10|NEP|NTRK4|PTK3|PTK3A|RTK6|TRKE | DBK|PAK-1|PAK1|PKN|PKN-ALPHA|PRK1|PRKCL1 | |
Cytomap | 6p21.33 | 19p13.12 | |
Type of gene | protein-coding | protein-coding | |
Description | epithelial discoidin domain-containing receptor 1CD167 antigen-like family member APTK3A protein tyrosine kinase 3Acell adhesion kinasemammary carcinoma kinase 10neuroepithelial tyrosine kinaseneurotrophic tyrosine kinase, receptor, type 4protein-t | serine/threonine-protein kinase N1protease-activated kinase 1protein kinase C-like 1protein kinase C-like PKNprotein kinase C-related kinase 1protein kinase PKN-alphaserine-threonine kinase Nserine/threonine protein kinase N | |
Modification date | 20200329 | 20200329 | |
UniProtAcc | Q08345 Main function of 5'-partner protein: FUNCTION: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. {ECO:0000250, ECO:0000269|PubMed:12065315, ECO:0000269|PubMed:16234985, ECO:0000269|PubMed:16337946, ECO:0000269|PubMed:19401332, ECO:0000269|PubMed:20093046, ECO:0000269|PubMed:20432435, ECO:0000269|PubMed:20884741, ECO:0000269|PubMed:21044884, ECO:0000269|PubMed:9659899}. | . | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000446312, ENST00000324771, ENST00000361741, ENST00000376567, ENST00000376568, ENST00000376569, ENST00000376570, ENST00000376575, ENST00000418800, ENST00000452441, ENST00000454612, ENST00000508312, ENST00000513240, ENST00000259875, ENST00000383377, ENST00000400410, ENST00000400411, ENST00000400414, ENST00000400486, ENST00000400488, ENST00000400489, ENST00000400491, ENST00000400492, ENST00000412329, ENST00000415092, ENST00000419412, ENST00000421229, ENST00000422628, ENST00000427053, ENST00000429699, ENST00000430933, ENST00000434428, ENST00000449518, ENST00000453510, ENST00000454774, ENST00000462241, ENST00000468225, ENST00000483193, ENST00000487780, ENST00000488414, ENST00000490712, ENST00000508472, ENST00000548133, ENST00000548693, ENST00000548962, ENST00000549026, ENST00000550384, ENST00000550395, ENST00000550666, ENST00000552068, ENST00000552434, ENST00000552721, ENST00000553015, | ENST00000278568, ENST00000356341, ENST00000528203, ENST00000530617, ENST00000525542, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 6 X 6 X 4=144 | 22 X 17 X 10=3740 |
# samples | 6 | 26 | |
** MAII score | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(26/3740*10)=-3.84645474174655 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Fusion gene context | PubMed: DDR1 [Title/Abstract] AND PAK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Fusion neoantigen context | PubMed: DDR1 [Title/Abstract] AND PAK1 [Title/Abstract] AND neoantigen [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | DDR1(30861200)-PAK1(77070062), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | DDR1-PAK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DDR1-PAK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DDR1-PAK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DDR1-PAK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DDR1 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway | 9659899|21044884 |
Hgene | DDR1 | GO:0038083 | peptidyl-tyrosine autophosphorylation | 21044884 |
Hgene | DDR1 | GO:0046777 | protein autophosphorylation | 9659899 |
Tgene | PAK1 | GO:0006357 | regulation of transcription by RNA polymerase II | 12514133 |
Tgene | PAK1 | GO:0006468 | protein phosphorylation | 17332740 |
Tgene | PAK1 | GO:0035407 | histone H3-T11 phosphorylation | 18066052 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:30861200/chr11:77070062) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Amino Acid Sequences |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000324771 | DDR1 | chr6 | 30861200 | + | ENST00000356341 | PAK1 | chr11 | 77070062 | - | 4623 | 1895 | 548 | 3055 | 835 |
ENST00000324771 | DDR1 | chr6 | 30861200 | + | ENST00000530617 | PAK1 | chr11 | 77070062 | - | 4107 | 1895 | 548 | 2986 | 812 |
ENST00000324771 | DDR1 | chr6 | 30861200 | + | ENST00000278568 | PAK1 | chr11 | 77070062 | - | 3431 | 1895 | 548 | 3079 | 843 |
ENST00000324771 | DDR1 | chr6 | 30861200 | + | ENST00000528203 | PAK1 | chr11 | 77070062 | - | 3355 | 1895 | 548 | 3079 | 843 |
ENST00000418800 | DDR1 | chr6 | 30861200 | + | ENST00000356341 | PAK1 | chr11 | 77070062 | - | 4488 | 1760 | 353 | 2920 | 855 |
ENST00000418800 | DDR1 | chr6 | 30861200 | + | ENST00000530617 | PAK1 | chr11 | 77070062 | - | 3972 | 1760 | 353 | 2851 | 832 |
ENST00000418800 | DDR1 | chr6 | 30861200 | + | ENST00000278568 | PAK1 | chr11 | 77070062 | - | 3296 | 1760 | 353 | 2944 | 863 |
ENST00000418800 | DDR1 | chr6 | 30861200 | + | ENST00000528203 | PAK1 | chr11 | 77070062 | - | 3220 | 1760 | 353 | 2944 | 863 |
ENST00000454612 | DDR1 | chr6 | 30861200 | + | ENST00000356341 | PAK1 | chr11 | 77070062 | - | 4526 | 1798 | 451 | 2958 | 835 |
ENST00000454612 | DDR1 | chr6 | 30861200 | + | ENST00000530617 | PAK1 | chr11 | 77070062 | - | 4010 | 1798 | 451 | 2889 | 812 |
ENST00000454612 | DDR1 | chr6 | 30861200 | + | ENST00000278568 | PAK1 | chr11 | 77070062 | - | 3334 | 1798 | 451 | 2982 | 843 |
ENST00000454612 | DDR1 | chr6 | 30861200 | + | ENST00000528203 | PAK1 | chr11 | 77070062 | - | 3258 | 1798 | 451 | 2982 | 843 |
ENST00000376569 | DDR1 | chr6 | 30861200 | + | ENST00000356341 | PAK1 | chr11 | 77070062 | - | 4367 | 1639 | 292 | 2799 | 835 |
ENST00000376569 | DDR1 | chr6 | 30861200 | + | ENST00000530617 | PAK1 | chr11 | 77070062 | - | 3851 | 1639 | 292 | 2730 | 812 |
ENST00000376569 | DDR1 | chr6 | 30861200 | + | ENST00000278568 | PAK1 | chr11 | 77070062 | - | 3175 | 1639 | 292 | 2823 | 843 |
ENST00000376569 | DDR1 | chr6 | 30861200 | + | ENST00000528203 | PAK1 | chr11 | 77070062 | - | 3099 | 1639 | 292 | 2823 | 843 |
ENST00000376575 | DDR1 | chr6 | 30861200 | + | ENST00000356341 | PAK1 | chr11 | 77070062 | - | 4408 | 1680 | 333 | 2840 | 835 |
ENST00000376575 | DDR1 | chr6 | 30861200 | + | ENST00000530617 | PAK1 | chr11 | 77070062 | - | 3892 | 1680 | 333 | 2771 | 812 |
ENST00000376575 | DDR1 | chr6 | 30861200 | + | ENST00000278568 | PAK1 | chr11 | 77070062 | - | 3216 | 1680 | 333 | 2864 | 843 |
ENST00000376575 | DDR1 | chr6 | 30861200 | + | ENST00000528203 | PAK1 | chr11 | 77070062 | - | 3140 | 1680 | 333 | 2864 | 843 |
ENST00000376570 | DDR1 | chr6 | 30861200 | + | ENST00000356341 | PAK1 | chr11 | 77070062 | - | 4408 | 1680 | 333 | 2840 | 835 |
ENST00000376570 | DDR1 | chr6 | 30861200 | + | ENST00000530617 | PAK1 | chr11 | 77070062 | - | 3892 | 1680 | 333 | 2771 | 812 |
ENST00000376570 | DDR1 | chr6 | 30861200 | + | ENST00000278568 | PAK1 | chr11 | 77070062 | - | 3216 | 1680 | 333 | 2864 | 843 |
ENST00000376570 | DDR1 | chr6 | 30861200 | + | ENST00000528203 | PAK1 | chr11 | 77070062 | - | 3140 | 1680 | 333 | 2864 | 843 |
ENST00000376568 | DDR1 | chr6 | 30861200 | + | ENST00000356341 | PAK1 | chr11 | 77070062 | - | 4370 | 1642 | 295 | 2802 | 835 |
ENST00000376568 | DDR1 | chr6 | 30861200 | + | ENST00000530617 | PAK1 | chr11 | 77070062 | - | 3854 | 1642 | 295 | 2733 | 812 |
ENST00000376568 | DDR1 | chr6 | 30861200 | + | ENST00000278568 | PAK1 | chr11 | 77070062 | - | 3178 | 1642 | 295 | 2826 | 843 |
ENST00000376568 | DDR1 | chr6 | 30861200 | + | ENST00000528203 | PAK1 | chr11 | 77070062 | - | 3102 | 1642 | 295 | 2826 | 843 |
ENST00000452441 | DDR1 | chr6 | 30861200 | + | ENST00000356341 | PAK1 | chr11 | 77070062 | - | 4334 | 1606 | 259 | 2766 | 835 |
ENST00000452441 | DDR1 | chr6 | 30861200 | + | ENST00000530617 | PAK1 | chr11 | 77070062 | - | 3818 | 1606 | 259 | 2697 | 812 |
ENST00000452441 | DDR1 | chr6 | 30861200 | + | ENST00000278568 | PAK1 | chr11 | 77070062 | - | 3142 | 1606 | 259 | 2790 | 843 |
ENST00000452441 | DDR1 | chr6 | 30861200 | + | ENST00000528203 | PAK1 | chr11 | 77070062 | - | 3066 | 1606 | 259 | 2790 | 843 |
ENST00000508312 | DDR1 | chr6 | 30861200 | + | ENST00000356341 | PAK1 | chr11 | 77070062 | - | 4381 | 1653 | 252 | 2813 | 853 |
ENST00000508312 | DDR1 | chr6 | 30861200 | + | ENST00000530617 | PAK1 | chr11 | 77070062 | - | 3865 | 1653 | 252 | 2744 | 830 |
ENST00000508312 | DDR1 | chr6 | 30861200 | + | ENST00000278568 | PAK1 | chr11 | 77070062 | - | 3189 | 1653 | 252 | 2837 | 861 |
ENST00000508312 | DDR1 | chr6 | 30861200 | + | ENST00000528203 | PAK1 | chr11 | 77070062 | - | 3113 | 1653 | 252 | 2837 | 861 |
ENST00000376567 | DDR1 | chr6 | 30861200 | + | ENST00000356341 | PAK1 | chr11 | 77070062 | - | 4416 | 1688 | 293 | 2848 | 851 |
ENST00000376567 | DDR1 | chr6 | 30861200 | + | ENST00000530617 | PAK1 | chr11 | 77070062 | - | 3900 | 1688 | 293 | 2779 | 828 |
ENST00000376567 | DDR1 | chr6 | 30861200 | + | ENST00000278568 | PAK1 | chr11 | 77070062 | - | 3224 | 1688 | 293 | 2872 | 859 |
ENST00000376567 | DDR1 | chr6 | 30861200 | + | ENST00000528203 | PAK1 | chr11 | 77070062 | - | 3148 | 1688 | 293 | 2872 | 859 |
ENST00000513240 | DDR1 | chr6 | 30861200 | + | ENST00000356341 | PAK1 | chr11 | 77070062 | - | 4075 | 1347 | 0 | 2507 | 835 |
ENST00000513240 | DDR1 | chr6 | 30861200 | + | ENST00000530617 | PAK1 | chr11 | 77070062 | - | 3559 | 1347 | 0 | 2438 | 812 |
ENST00000513240 | DDR1 | chr6 | 30861200 | + | ENST00000278568 | PAK1 | chr11 | 77070062 | - | 2883 | 1347 | 0 | 2531 | 843 |
ENST00000513240 | DDR1 | chr6 | 30861200 | + | ENST00000528203 | PAK1 | chr11 | 77070062 | - | 2807 | 1347 | 0 | 2531 | 843 |
ENST00000361741 | DDR1 | chr6 | 30861200 | + | ENST00000356341 | PAK1 | chr11 | 77070062 | - | 3463 | 735 | 54 | 1895 | 613 |
ENST00000361741 | DDR1 | chr6 | 30861200 | + | ENST00000530617 | PAK1 | chr11 | 77070062 | - | 2947 | 735 | 54 | 1826 | 590 |
ENST00000361741 | DDR1 | chr6 | 30861200 | + | ENST00000278568 | PAK1 | chr11 | 77070062 | - | 2271 | 735 | 54 | 1919 | 621 |
ENST00000361741 | DDR1 | chr6 | 30861200 | + | ENST00000528203 | PAK1 | chr11 | 77070062 | - | 2195 | 735 | 54 | 1919 | 621 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000324771 | ENST00000356341 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.00354635 | 0.99645364 |
ENST00000324771 | ENST00000530617 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.004507507 | 0.99549246 |
ENST00000324771 | ENST00000278568 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.005860102 | 0.9941399 |
ENST00000324771 | ENST00000528203 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.007287622 | 0.9927124 |
ENST00000418800 | ENST00000356341 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.002930601 | 0.9970694 |
ENST00000418800 | ENST00000530617 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.003844881 | 0.9961551 |
ENST00000418800 | ENST00000278568 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.004749602 | 0.99525034 |
ENST00000418800 | ENST00000528203 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.005931235 | 0.99406874 |
ENST00000454612 | ENST00000356341 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.003171575 | 0.9968284 |
ENST00000454612 | ENST00000530617 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.004040426 | 0.9959596 |
ENST00000454612 | ENST00000278568 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.005101979 | 0.994898 |
ENST00000454612 | ENST00000528203 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.006366759 | 0.9936333 |
ENST00000376569 | ENST00000356341 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.003238619 | 0.9967614 |
ENST00000376569 | ENST00000530617 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.00417776 | 0.9958222 |
ENST00000376569 | ENST00000278568 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.005536543 | 0.9944635 |
ENST00000376569 | ENST00000528203 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.007001235 | 0.9929987 |
ENST00000376575 | ENST00000356341 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.003364295 | 0.99663574 |
ENST00000376575 | ENST00000530617 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.004303785 | 0.9956962 |
ENST00000376575 | ENST00000278568 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.005665423 | 0.9943346 |
ENST00000376575 | ENST00000528203 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.007145989 | 0.99285406 |
ENST00000376570 | ENST00000356341 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.003364295 | 0.99663574 |
ENST00000376570 | ENST00000530617 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.004303785 | 0.9956962 |
ENST00000376570 | ENST00000278568 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.005665423 | 0.9943346 |
ENST00000376570 | ENST00000528203 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.007145989 | 0.99285406 |
ENST00000376568 | ENST00000356341 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.003319103 | 0.9966809 |
ENST00000376568 | ENST00000530617 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.004245135 | 0.99575484 |
ENST00000376568 | ENST00000278568 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.005660356 | 0.99433964 |
ENST00000376568 | ENST00000528203 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.007159812 | 0.9928402 |
ENST00000452441 | ENST00000356341 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.003379146 | 0.9966209 |
ENST00000452441 | ENST00000530617 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.004342227 | 0.9956578 |
ENST00000452441 | ENST00000278568 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.005765558 | 0.9942345 |
ENST00000452441 | ENST00000528203 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.007286518 | 0.9927135 |
ENST00000508312 | ENST00000356341 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.003368288 | 0.9966317 |
ENST00000508312 | ENST00000530617 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.004332284 | 0.9956677 |
ENST00000508312 | ENST00000278568 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.005699435 | 0.9943006 |
ENST00000508312 | ENST00000528203 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.007169371 | 0.9928307 |
ENST00000376567 | ENST00000356341 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.002035717 | 0.99796426 |
ENST00000376567 | ENST00000530617 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.002628157 | 0.9973718 |
ENST00000376567 | ENST00000278568 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.003325224 | 0.9966748 |
ENST00000376567 | ENST00000528203 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.004157855 | 0.99584216 |
ENST00000513240 | ENST00000356341 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.002895839 | 0.9971041 |
ENST00000513240 | ENST00000530617 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.00379967 | 0.99620026 |
ENST00000513240 | ENST00000278568 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.005199905 | 0.9948001 |
ENST00000513240 | ENST00000528203 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.006705619 | 0.9932943 |
ENST00000361741 | ENST00000356341 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.00425238 | 0.9957476 |
ENST00000361741 | ENST00000530617 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.00506943 | 0.99493057 |
ENST00000361741 | ENST00000278568 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.009053835 | 0.9909462 |
ENST00000361741 | ENST00000528203 | DDR1 | chr6 | 30861200 | + | PAK1 | chr11 | 77070062 | - | 0.011564052 | 0.988436 |
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Get the fusion protein sequences from here. |
Fusion protein sequence information is available in the fasta format. >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP |
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Fusion Protein Breakpoint Sequences for DDR1-PAK1 |
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Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Length(fusion protein) | BP in fusion protein | Peptide |
DDR1 | chr6 | 30861200 | PAK1 | chr11 | 77070062 | 1347 | 449 | MLWRLHWRRLLSKNVKAVSETPAVPP |
DDR1 | chr6 | 30861200 | PAK1 | chr11 | 77070062 | 1606 | 449 | MLWRLHWRRLLSKNVKAVSETPAVPP |
DDR1 | chr6 | 30861200 | PAK1 | chr11 | 77070062 | 1639 | 449 | MLWRLHWRRLLSKNVKAVSETPAVPP |
DDR1 | chr6 | 30861200 | PAK1 | chr11 | 77070062 | 1642 | 449 | MLWRLHWRRLLSKNVKAVSETPAVPP |
DDR1 | chr6 | 30861200 | PAK1 | chr11 | 77070062 | 1653 | 467 | MLWRLHWRRLLSKNVKAVSETPAVPP |
DDR1 | chr6 | 30861200 | PAK1 | chr11 | 77070062 | 1680 | 449 | MLWRLHWRRLLSKNVKAVSETPAVPP |
DDR1 | chr6 | 30861200 | PAK1 | chr11 | 77070062 | 1688 | 465 | MLWRLHWRRLLSKNVKAVSETPAVPP |
DDR1 | chr6 | 30861200 | PAK1 | chr11 | 77070062 | 1760 | 469 | MLWRLHWRRLLSKNVKAVSETPAVPP |
DDR1 | chr6 | 30861200 | PAK1 | chr11 | 77070062 | 1798 | 449 | MLWRLHWRRLLSKNVKAVSETPAVPP |
DDR1 | chr6 | 30861200 | PAK1 | chr11 | 77070062 | 1895 | 449 | MLWRLHWRRLLSKNVKAVSETPAVPP |
DDR1 | chr6 | 30861200 | PAK1 | chr11 | 77070062 | 735 | 227 | MLWRLHWRRLLSKNVKAVSETPAVPP |
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Potential FusionNeoAntigen Information of DDR1-PAK1 in HLA I |
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DDR1-PAK1_30861200_77070062.msa |
![]() * We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5) |
Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA I | FusionNeoAntigen peptide | Binding score | Immunogenic score | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | HLA-B27:05 | RRLLSKNVK | 0.999 | 0.8653 | 7 | 16 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | HLA-A02:13 | LLSKNVKAV | 0.9914 | 0.5348 | 9 | 18 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | HLA-A02:11 | RLLSKNVKA | 0.9816 | 0.5452 | 8 | 17 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | HLA-A02:13 | RLLSKNVKA | 0.9508 | 0.5775 | 8 | 17 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | HLA-A02:29 | RLLSKNVKA | 0.844 | 0.5038 | 8 | 17 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | HLA-A02:20 | RLLSKNVKA | 0.8028 | 0.5049 | 8 | 17 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | HLA-A02:13 | RLLSKNVKAV | 0.9883 | 0.6092 | 8 | 18 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | HLA-A02:27 | RLLSKNVKAV | 0.9822 | 0.5233 | 8 | 18 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | HLA-B27:14 | RRLLSKNVK | 0.9986 | 0.7798 | 7 | 16 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | HLA-B27:03 | RRLLSKNVK | 0.9572 | 0.8882 | 7 | 16 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | HLA-B27:14 | RRLLSKNVKA | 0.9998 | 0.8201 | 7 | 17 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | HLA-B27:10 | RRLLSKNVK | 0.9985 | 0.7799 | 7 | 16 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | HLA-A02:03 | LLSKNVKAV | 0.998 | 0.5875 | 9 | 18 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | HLA-B27:08 | RRLLSKNVK | 0.9979 | 0.7189 | 7 | 16 |
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Potential FusionNeoAntigen Information of DDR1-PAK1 in HLA II |
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DDR1-PAK1_30861200_77070062.msa |
![]() * We used NetMHCIIpan v4.1 (%rank<0.5). |
Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA II | FusionNeoAntigen peptide | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | DRB1-0103 | RLHWRRLLSKNVKAV | 3 | 18 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | DRB1-0103 | WRLHWRRLLSKNVKA | 2 | 17 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | DRB1-0109 | RLHWRRLLSKNVKAV | 3 | 18 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | DRB1-0115 | RLHWRRLLSKNVKAV | 3 | 18 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | DRB1-0115 | WRLHWRRLLSKNVKA | 2 | 17 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | DRB1-0906 | SKNVKAVSETPAVPP | 11 | 26 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | DRB1-1503 | SKNVKAVSETPAVPP | 11 | 26 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | DRB1-1503 | LSKNVKAVSETPAVP | 10 | 25 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | DRB1-1523 | SKNVKAVSETPAVPP | 11 | 26 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | DRB1-1523 | LSKNVKAVSETPAVP | 10 | 25 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | DRB1-1609 | RLHWRRLLSKNVKAV | 3 | 18 |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 | DRB1-1609 | WRLHWRRLLSKNVKA | 2 | 17 |
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Fusion breakpoint peptide structures of DDR1-PAK1 |
![]() * The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA. |
File name | BPseq | Hgene | Tgene | Hchr | Hbp | Tchr | Tbp | AAlen |
10538 | WRRLLSKNVKAVSE | DDR1 | PAK1 | chr6 | 30861200 | chr11 | 77070062 | 1895 |
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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of DDR1-PAK1 |
![]() * We used Glide to predict the interaction between HLAs and neoantigens. |
HLA allele | PDB ID | File name | BPseq | Docking score | Glide score |
HLA-B14:02 | 3BVN | 10538 | WRRLLSKNVKAVSE | -7.02924 | -7.14264 |
HLA-B14:02 | 3BVN | 10538 | WRRLLSKNVKAVSE | -3.38077 | -4.41607 |
HLA-B52:01 | 3W39 | 10538 | WRRLLSKNVKAVSE | -6.41355 | -6.52695 |
HLA-B52:01 | 3W39 | 10538 | WRRLLSKNVKAVSE | -4.44188 | -5.47718 |
HLA-A24:02 | 5HGA | 10538 | WRRLLSKNVKAVSE | -7.76595 | -8.80125 |
HLA-A24:02 | 5HGA | 10538 | WRRLLSKNVKAVSE | -7.30892 | -7.42232 |
HLA-B44:05 | 3DX8 | 10538 | WRRLLSKNVKAVSE | -5.65486 | -5.76826 |
HLA-B44:05 | 3DX8 | 10538 | WRRLLSKNVKAVSE | -2.95775 | -3.99305 |
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Vaccine Design for the FusionNeoAntigens of DDR1-PAK1 |
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Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide sequence | FusionNeoAntigen RNA sequence |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 7 | 16 | RRLLSKNVK | CGCAGGCTCCTCAGCAAGAATGTGAAG |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 7 | 17 | RRLLSKNVKA | CGCAGGCTCCTCAGCAAGAATGTGAAGGCT |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 8 | 17 | RLLSKNVKA | AGGCTCCTCAGCAAGAATGTGAAGGCT |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 8 | 18 | RLLSKNVKAV | AGGCTCCTCAGCAAGAATGTGAAGGCTGTG |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 9 | 18 | LLSKNVKAV | CTCCTCAGCAAGAATGTGAAGGCTGTG |
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Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide | FusionNEoAntigen RNA sequence |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 10 | 25 | LSKNVKAVSETPAVP | CTCAGCAAGAATGTGAAGGCTGTGTCTGAGACTCCTGCAGTGCCA |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 11 | 26 | SKNVKAVSETPAVPP | AGCAAGAATGTGAAGGCTGTGTCTGAGACTCCTGCAGTGCCACCA |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 2 | 17 | WRLHWRRLLSKNVKA | TGGCGGCTGCACTGGCGCAGGCTCCTCAGCAAGAATGTGAAGGCT |
DDR1-PAK1 | chr6 | 30861200 | chr11 | 77070062 | 3 | 18 | RLHWRRLLSKNVKAV | CGGCTGCACTGGCGCAGGCTCCTCAGCAAGAATGTGAAGGCTGTG |
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Information of the samples that have these potential fusion neoantigens of DDR1-PAK1 |
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Cancer type | Fusion gene | Hchr | Hbp | Henst | Tchr | Tbp | Tenst | Sample |
OV | DDR1-PAK1 | chr6 | 30861200 | ENST00000324771 | chr11 | 77070062 | ENST00000278568 | TCGA-13-1477-01A |
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Potential target of CAR-T therapy development for DDR1-PAK1 |
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![]() * Minus value of BPloci means that the break point is located before the CDS. |
- In-frame and retained 'Transmembrane'. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | DDR1 | chr6:30861200 | chr11:77070062 | ENST00000324771 | + | 12 | 20 | 418_438 | 449 | 914.0 | Transmembrane | Helical |
Hgene | DDR1 | chr6:30861200 | chr11:77070062 | ENST00000376567 | + | 9 | 16 | 418_438 | 449 | 877.0 | Transmembrane | Helical |
Hgene | DDR1 | chr6:30861200 | chr11:77070062 | ENST00000376568 | + | 10 | 18 | 418_438 | 449 | 914.0 | Transmembrane | Helical |
Hgene | DDR1 | chr6:30861200 | chr11:77070062 | ENST00000376569 | + | 11 | 18 | 418_438 | 449 | 877.0 | Transmembrane | Helical |
Hgene | DDR1 | chr6:30861200 | chr11:77070062 | ENST00000376570 | + | 12 | 19 | 418_438 | 449 | 877.0 | Transmembrane | Helical |
Hgene | DDR1 | chr6:30861200 | chr11:77070062 | ENST00000376575 | + | 12 | 20 | 418_438 | 449 | 920.0 | Transmembrane | Helical |
Hgene | DDR1 | chr6:30861200 | chr11:77070062 | ENST00000418800 | + | 10 | 17 | 418_438 | 449 | 877.0 | Transmembrane | Helical |
Hgene | DDR1 | chr6:30861200 | chr11:77070062 | ENST00000452441 | + | 11 | 19 | 418_438 | 449 | 914.0 | Transmembrane | Helical |
Hgene | DDR1 | chr6:30861200 | chr11:77070062 | ENST00000454612 | + | 14 | 21 | 418_438 | 449 | 877.0 | Transmembrane | Helical |
Hgene | DDR1 | chr6:30861200 | chr11:77070062 | ENST00000508312 | + | 10 | 17 | 418_438 | 467 | 895.0 | Transmembrane | Helical |
Hgene | DDR1 | chr6:30861200 | chr11:77070062 | ENST00000513240 | + | 9 | 17 | 418_438 | 449 | 920.0 | Transmembrane | Helical |
![]() * We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image. |
Hgene | Hchr | Hbp | Henst | Tgene | Tchr | Tbp | Tenst | DeepLoc result |
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Related Drugs to DDR1-PAK1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to DDR1-PAK1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |