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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:DNM2-SMARCA4

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DNM2-SMARCA4
FusionPDB ID: 23660
FusionGDB2.0 ID: 23660
HgeneTgene
Gene symbol

DNM2

SMARCA4

Gene ID

1785

6597

Gene namedynamin 2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SynonymsCMT2M|CMTDI1|CMTDIB|DI-CMTB|DYN2|DYNII|LCCS5BAF190|BAF190A|BRG1|CSS4|MRD16|RTPS2|SNF2|SNF2-beta|SNF2L4|SNF2LB|SWI2|hSNF2b
Cytomap

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptiondynamin-2dynamin IItranscription activator BRG1ATP-dependent helicase SMARCA4BRG1-associated factor 190ABRM/SWI2-related gene 1SNF2-like 4brahma protein-like 1global transcription activator homologous sequencehomeotic gene regulatormitotic growth and transcription a
Modification date2020032920200315
UniProtAcc

P50570

Main function of 5'-partner protein: FUNCTION: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis (PubMed:12498685). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:12498685}.		.
Ensembl transtripts involved in fusion geneENST idsENST00000314646, ENST00000355667, 
ENST00000359692, ENST00000389253, 
ENST00000408974, ENST00000585892, 
ENST00000591819, 		ENST00000344626, 
ENST00000358026, ENST00000429416, 
ENST00000444061, ENST00000541122, 
ENST00000589677, ENST00000590574, 
ENST00000413806, ENST00000450717, 
ENST00000538456, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score36 X 17 X 17=1040420 X 28 X 15=8400
# samples 4932
** MAII scorelog2(49/10404*10)=-4.40821274494042
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(32/8400*10)=-4.71424551766612
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: DNM2 [Title/Abstract] AND SMARCA4 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: DNM2 [Title/Abstract] AND SMARCA4 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SMARCA4(11071850)-DNM2(10916591), # samples:2
SMARCA4(11071850)-DNM2(10883155), # samples:2
SMARCA4(11170863)-DNM2(10939712), # samples:2
DNM2(10829079)-SMARCA4(11132400), # samples:1
DNM2(10829079)-SMARCA4(11129632), # samples:1
DNM2(10829079)-SMARCA4(11094800), # samples:1
DNM2(10829079)-SMARCA4(11132401), # samples:1
Anticipated loss of major functional domain due to fusion event.DNM2-SMARCA4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM2-SMARCA4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM2-SMARCA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM2-SMARCA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SMARCA4-DNM2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SMARCA4-DNM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM2-SMARCA4 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
DNM2-SMARCA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DNM2-SMARCA4 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
DNM2-SMARCA4 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
DNM2-SMARCA4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
DNM2-SMARCA4 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNM2

GO:1903526

negative regulation of membrane tubulation

18388313

TgeneSMARCA4

GO:0006337

nucleosome disassembly

8895581

TgeneSMARCA4

GO:0006338

chromatin remodeling

10943845|11726552

TgeneSMARCA4

GO:0045892

negative regulation of transcription, DNA-templated

12065415

TgeneSMARCA4

GO:0045944

positive regulation of transcription by RNA polymerase II

15774904|17938176

TgeneSMARCA4

GO:0051091

positive regulation of DNA-binding transcription factor activity

11950834|17938176

TgeneSMARCA4

GO:1902661

positive regulation of glucose mediated signaling pathway

22368283



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:11071850/chr19:10916591)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across DNM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SMARCA4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000585892DNM2chr1910829079+ENST00000358026SMARCA4chr1911129632+33933251642926920
ENST00000585892DNM2chr1910829079+ENST00000344626SMARCA4chr1911129632+30743251642830888
ENST00000585892DNM2chr1910829079+ENST00000429416SMARCA4chr1911129632+32973251642830888
ENST00000585892DNM2chr1910829079+ENST00000541122SMARCA4chr1911129632+27413251642740859
ENST00000585892DNM2chr1910829079+ENST00000589677SMARCA4chr1911129632+27383251642737858
ENST00000585892DNM2chr1910829079+ENST00000444061SMARCA4chr1911129632+27293251642728855
ENST00000585892DNM2chr1910829079+ENST00000590574SMARCA4chr1911129632+27323251642731856
ENST00000585892DNM2chr1910829079+ENST00000413806SMARCA4chr1911129632+32073251642740858
ENST00000585892DNM2chr1910829079+ENST00000450717SMARCA4chr1911129632+32043251642737857
ENST00000314646DNM2chr1910829079+ENST00000358026SMARCA4chr1911129632+33933251642926920
ENST00000314646DNM2chr1910829079+ENST00000344626SMARCA4chr1911129632+30743251642830888
ENST00000314646DNM2chr1910829079+ENST00000429416SMARCA4chr1911129632+32973251642830888
ENST00000314646DNM2chr1910829079+ENST00000541122SMARCA4chr1911129632+27413251642740859
ENST00000314646DNM2chr1910829079+ENST00000589677SMARCA4chr1911129632+27383251642737858
ENST00000314646DNM2chr1910829079+ENST00000444061SMARCA4chr1911129632+27293251642728855
ENST00000314646DNM2chr1910829079+ENST00000590574SMARCA4chr1911129632+27323251642731856
ENST00000314646DNM2chr1910829079+ENST00000413806SMARCA4chr1911129632+32073251642740858
ENST00000314646DNM2chr1910829079+ENST00000450717SMARCA4chr1911129632+32043251642737857
ENST00000359692DNM2chr1910829079+ENST00000358026SMARCA4chr1911129632+33793111502912920
ENST00000359692DNM2chr1910829079+ENST00000344626SMARCA4chr1911129632+30603111502816888
ENST00000359692DNM2chr1910829079+ENST00000429416SMARCA4chr1911129632+32833111502816888
ENST00000359692DNM2chr1910829079+ENST00000541122SMARCA4chr1911129632+27273111502726858
ENST00000359692DNM2chr1910829079+ENST00000589677SMARCA4chr1911129632+27243111502723857
ENST00000359692DNM2chr1910829079+ENST00000444061SMARCA4chr1911129632+27153111502714854
ENST00000359692DNM2chr1910829079+ENST00000590574SMARCA4chr1911129632+27183111502717855
ENST00000359692DNM2chr1910829079+ENST00000413806SMARCA4chr1911129632+31933111502726858
ENST00000359692DNM2chr1910829079+ENST00000450717SMARCA4chr1911129632+31903111502723857
ENST00000389253DNM2chr1910829079+ENST00000358026SMARCA4chr1911129632+33412731122874920
ENST00000389253DNM2chr1910829079+ENST00000344626SMARCA4chr1911129632+30222731122778888
ENST00000389253DNM2chr1910829079+ENST00000429416SMARCA4chr1911129632+32452731122778888
ENST00000389253DNM2chr1910829079+ENST00000541122SMARCA4chr1911129632+26892731122688859
ENST00000389253DNM2chr1910829079+ENST00000589677SMARCA4chr1911129632+26862731122685858
ENST00000389253DNM2chr1910829079+ENST00000444061SMARCA4chr1911129632+26772731122676855
ENST00000389253DNM2chr1910829079+ENST00000590574SMARCA4chr1911129632+26802731122679856
ENST00000389253DNM2chr1910829079+ENST00000413806SMARCA4chr1911129632+31552731122688858
ENST00000389253DNM2chr1910829079+ENST00000450717SMARCA4chr1911129632+31522731122685857
ENST00000355667DNM2chr1910829079+ENST00000358026SMARCA4chr1911129632+3309241802842920
ENST00000355667DNM2chr1910829079+ENST00000344626SMARCA4chr1911129632+2990241802746888
ENST00000355667DNM2chr1910829079+ENST00000429416SMARCA4chr1911129632+3213241802746888
ENST00000355667DNM2chr1910829079+ENST00000541122SMARCA4chr1911129632+2657241802656859
ENST00000355667DNM2chr1910829079+ENST00000589677SMARCA4chr1911129632+2654241802653858
ENST00000355667DNM2chr1910829079+ENST00000444061SMARCA4chr1911129632+2645241802644855
ENST00000355667DNM2chr1910829079+ENST00000590574SMARCA4chr1911129632+2648241802647856
ENST00000355667DNM2chr1910829079+ENST00000413806SMARCA4chr1911129632+3123241802656858
ENST00000355667DNM2chr1910829079+ENST00000450717SMARCA4chr1911129632+3120241802653857
ENST00000408974DNM2chr1910829079+ENST00000358026SMARCA4chr1911129632+3264196352797920
ENST00000408974DNM2chr1910829079+ENST00000344626SMARCA4chr1911129632+2945196352701888
ENST00000408974DNM2chr1910829079+ENST00000429416SMARCA4chr1911129632+3168196352701888
ENST00000408974DNM2chr1910829079+ENST00000541122SMARCA4chr1911129632+2612196352611859
ENST00000408974DNM2chr1910829079+ENST00000589677SMARCA4chr1911129632+2609196352608858
ENST00000408974DNM2chr1910829079+ENST00000444061SMARCA4chr1911129632+2600196352599855
ENST00000408974DNM2chr1910829079+ENST00000590574SMARCA4chr1911129632+2603196352602856
ENST00000408974DNM2chr1910829079+ENST00000413806SMARCA4chr1911129632+3078196352611858
ENST00000408974DNM2chr1910829079+ENST00000450717SMARCA4chr1911129632+3075196352608857

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000585892ENST00000358026DNM2chr1910829079+SMARCA4chr1911129632+0.0144640.9855359
ENST00000585892ENST00000344626DNM2chr1910829079+SMARCA4chr1911129632+0.021845760.9781543
ENST00000585892ENST00000429416DNM2chr1910829079+SMARCA4chr1911129632+0.0176166740.9823834
ENST00000585892ENST00000541122DNM2chr1910829079+SMARCA4chr1911129632+0.0236335960.9763664
ENST00000585892ENST00000589677DNM2chr1910829079+SMARCA4chr1911129632+0.02371160.97628844
ENST00000585892ENST00000444061DNM2chr1910829079+SMARCA4chr1911129632+0.0234061960.97659385
ENST00000585892ENST00000590574DNM2chr1910829079+SMARCA4chr1911129632+0.0234069660.976593
ENST00000585892ENST00000413806DNM2chr1910829079+SMARCA4chr1911129632+0.0192320010.980768
ENST00000585892ENST00000450717DNM2chr1910829079+SMARCA4chr1911129632+0.0190583880.98094165
ENST00000314646ENST00000358026DNM2chr1910829079+SMARCA4chr1911129632+0.0144640.9855359
ENST00000314646ENST00000344626DNM2chr1910829079+SMARCA4chr1911129632+0.021845760.9781543
ENST00000314646ENST00000429416DNM2chr1910829079+SMARCA4chr1911129632+0.0176166740.9823834
ENST00000314646ENST00000541122DNM2chr1910829079+SMARCA4chr1911129632+0.0236335960.9763664
ENST00000314646ENST00000589677DNM2chr1910829079+SMARCA4chr1911129632+0.02371160.97628844
ENST00000314646ENST00000444061DNM2chr1910829079+SMARCA4chr1911129632+0.0234061960.97659385
ENST00000314646ENST00000590574DNM2chr1910829079+SMARCA4chr1911129632+0.0234069660.976593
ENST00000314646ENST00000413806DNM2chr1910829079+SMARCA4chr1911129632+0.0192320010.980768
ENST00000314646ENST00000450717DNM2chr1910829079+SMARCA4chr1911129632+0.0190583880.98094165
ENST00000359692ENST00000358026DNM2chr1910829079+SMARCA4chr1911129632+0.0142826060.9857174
ENST00000359692ENST00000344626DNM2chr1910829079+SMARCA4chr1911129632+0.0219393990.97806066
ENST00000359692ENST00000429416DNM2chr1910829079+SMARCA4chr1911129632+0.0175498150.98245025
ENST00000359692ENST00000541122DNM2chr1910829079+SMARCA4chr1911129632+0.0239772630.9760227
ENST00000359692ENST00000589677DNM2chr1910829079+SMARCA4chr1911129632+0.0239477080.9760523
ENST00000359692ENST00000444061DNM2chr1910829079+SMARCA4chr1911129632+0.0237788330.97622114
ENST00000359692ENST00000590574DNM2chr1910829079+SMARCA4chr1911129632+0.0238157250.97618425
ENST00000359692ENST00000413806DNM2chr1910829079+SMARCA4chr1911129632+0.0191233850.9808766
ENST00000359692ENST00000450717DNM2chr1910829079+SMARCA4chr1911129632+0.0189330340.98106694
ENST00000389253ENST00000358026DNM2chr1910829079+SMARCA4chr1911129632+0.0142257020.9857743
ENST00000389253ENST00000344626DNM2chr1910829079+SMARCA4chr1911129632+0.0220057740.97799426
ENST00000389253ENST00000429416DNM2chr1910829079+SMARCA4chr1911129632+0.0175443220.9824556
ENST00000389253ENST00000541122DNM2chr1910829079+SMARCA4chr1911129632+0.0241129640.97588706
ENST00000389253ENST00000589677DNM2chr1910829079+SMARCA4chr1911129632+0.0241067370.9758933
ENST00000389253ENST00000444061DNM2chr1910829079+SMARCA4chr1911129632+0.023920440.9760795
ENST00000389253ENST00000590574DNM2chr1910829079+SMARCA4chr1911129632+0.0239521670.9760478
ENST00000389253ENST00000413806DNM2chr1910829079+SMARCA4chr1911129632+0.0191189930.980881
ENST00000389253ENST00000450717DNM2chr1910829079+SMARCA4chr1911129632+0.0189332630.9810667
ENST00000355667ENST00000358026DNM2chr1910829079+SMARCA4chr1911129632+0.0142481540.9857518
ENST00000355667ENST00000344626DNM2chr1910829079+SMARCA4chr1911129632+0.0218949220.9781051
ENST00000355667ENST00000429416DNM2chr1910829079+SMARCA4chr1911129632+0.0175418070.9824582
ENST00000355667ENST00000541122DNM2chr1910829079+SMARCA4chr1911129632+0.0238989890.976101
ENST00000355667ENST00000589677DNM2chr1910829079+SMARCA4chr1911129632+0.0239429960.97605705
ENST00000355667ENST00000444061DNM2chr1910829079+SMARCA4chr1911129632+0.0236209180.9763791
ENST00000355667ENST00000590574DNM2chr1910829079+SMARCA4chr1911129632+0.0235598030.97644013
ENST00000355667ENST00000413806DNM2chr1910829079+SMARCA4chr1911129632+0.0191438760.9808561
ENST00000355667ENST00000450717DNM2chr1910829079+SMARCA4chr1911129632+0.0189657530.9810342
ENST00000408974ENST00000358026DNM2chr1910829079+SMARCA4chr1911129632+0.0148801580.9851199
ENST00000408974ENST00000344626DNM2chr1910829079+SMARCA4chr1911129632+0.0229503770.9770496
ENST00000408974ENST00000429416DNM2chr1910829079+SMARCA4chr1911129632+0.0183654240.98163456
ENST00000408974ENST00000541122DNM2chr1910829079+SMARCA4chr1911129632+0.024995750.97500426
ENST00000408974ENST00000589677DNM2chr1910829079+SMARCA4chr1911129632+0.0250403270.97495973
ENST00000408974ENST00000444061DNM2chr1910829079+SMARCA4chr1911129632+0.0248288640.9751711
ENST00000408974ENST00000590574DNM2chr1910829079+SMARCA4chr1911129632+0.0248623020.97513765
ENST00000408974ENST00000413806DNM2chr1910829079+SMARCA4chr1911129632+0.019890460.9801096
ENST00000408974ENST00000450717DNM2chr1910829079+SMARCA4chr1911129632+0.0197034460.9802965

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for DNM2-SMARCA4

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide

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Potential FusionNeoAntigen Information of DNM2-SMARCA4 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Potential FusionNeoAntigen Information of DNM2-SMARCA4 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Fusion breakpoint peptide structures of DNM2-SMARCA4

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of DNM2-SMARCA4

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score

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Vaccine Design for the FusionNeoAntigens of DNM2-SMARCA4

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence

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Information of the samples that have these potential fusion neoantigens of DNM2-SMARCA4

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample

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Potential target of CAR-T therapy development for DNM2-SMARCA4

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to DNM2-SMARCA4

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DNM2-SMARCA4

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource