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Fusion Protein:EML4-ALK

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: EML4-ALK
	FusionPDB ID: 26454
	FusionGDB2.0 ID: 26454
		Hgene	Tgene
	Gene symbol	EML4	ALK
	Gene ID	27436	238
	Gene name	EMAP like 4	ALK receptor tyrosine kinase
	Synonyms	C2orf2\|ELP120\|EMAP-4\|EMAPL4\|ROPP120	CD246\|NBLST3
	Cytomap	2p21	2p23.2-p23.1
	Type of gene	protein-coding	protein-coding
	Description	echinoderm microtubule-associated protein-like 4echinoderm microtubule associated protein like 4restrictedly overexpressed proliferation-associated proteinropp 120	ALK tyrosine kinase receptorCD246 antigenanaplastic lymphoma receptor tyrosine kinasemutant anaplastic lymphoma kinase
	Modification date	20200313	20200329
	UniProtAcc	Q9HC35 Main function of 5'-partner protein: FUNCTION: Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269\|PubMed:16890222, ECO:0000269\|PubMed:25789526, ECO:0000269\|PubMed:31409757}.	Q96BT7 Main function of 5'-partner protein: FUNCTION: Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323, PubMed:31079898). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182). {ECO:0000269\|PubMed:19293182, ECO:0000269\|PubMed:20123966, ECO:0000269\|PubMed:20308323, ECO:0000269\|PubMed:21285950, ECO:0000269\|PubMed:31079898}.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000318522, ENST00000401738, ENST00000402711, ENST00000453191, ENST00000482660,	ENST00000389048, ENST00000431873, ENST00000498037,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	22 X 32 X 18=12672	56 X 74 X 20=82880
	# samples	43	57
	** MAII score	log2(43/12672*10)=-4.88116377049015 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(57/82880*10)=-7.18391827352181 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: EML4 [Title/Abstract] AND ALK [Title/Abstract] AND fusion [Title/Abstract] Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer (pmid: 17625570)
Fusion neoantigen context	PubMed: EML4 [Title/Abstract] AND ALK [Title/Abstract] AND neoantigen [Title/Abstract] Successful rechallenge with ceritinib after leukocytoclastic vasculitis during ceritinib treatment for non-small cell lung cancer harboring the EML4-ALK fusion protein.', 'The growth of non-solid neoplastic lung nodules is associated with low PD L1 expression, irrespective of sampling technique.' (pmid: 29732013, 32013991)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	EML4(42552694)-ALK(29446394), # samples:6
Anticipated loss of major functional domain due to fusion event.	EML4-ALK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EML4-ALK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EML4-ALK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EML4-ALK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EML4-ALK seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. EML4-ALK seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. EML4-ALK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. EML4-ALK seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ALK	GO:0016310	phosphorylation	9174053
Tgene	ALK	GO:0046777	protein autophosphorylation	9174053

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:42552694/chr2:29446394)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across EML4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ALK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000318522	EML4	chr2	42491870	+	ENST00000389048	ALK	chr2	29446393	-	3070	929	262	2619	785
ENST00000402711	EML4	chr2	42491870	+	ENST00000389048	ALK	chr2	29446393	-	2893	752	259	2442	727
ENST00000401738	EML4	chr2	42491870	+	ENST00000389048	ALK	chr2	29446393	-	2959	818	151	2508	785
ENST00000318522	EML4	chr2	42491871	+	ENST00000389048	ALK	chr2	29446394	-	3070	929	262	2619	785
ENST00000402711	EML4	chr2	42491871	+	ENST00000389048	ALK	chr2	29446394	-	2893	752	259	2442	727
ENST00000401738	EML4	chr2	42491871	+	ENST00000389048	ALK	chr2	29446394	-	2959	818	151	2508	785
ENST00000401738	EML4	chr2	42492090	+	ENST00000389048	ALK	chr2	29446393	-	2992	851	151	2541	796
ENST00000401738	EML4	chr2	42492091	+	ENST00000389048	ALK	chr2	29446394	-	2992	851	151	2541	796
ENST00000318522	EML4	chr2	42522656	+	ENST00000389048	ALK	chr2	29446393	-	3892	1751	262	3441	1059
ENST00000402711	EML4	chr2	42522656	+	ENST00000389048	ALK	chr2	29446393	-	3715	1574	259	3264	1001
ENST00000401738	EML4	chr2	42522656	+	ENST00000389048	ALK	chr2	29446393	-	3814	1673	151	3363	1070
ENST00000318522	EML4	chr2	42522656	+	ENST00000389048	ALK	chr2	29446394	-	3892	1751	262	3441	1059
ENST00000402711	EML4	chr2	42522656	+	ENST00000389048	ALK	chr2	29446394	-	3715	1574	259	3264	1001
ENST00000401738	EML4	chr2	42522656	+	ENST00000389048	ALK	chr2	29446394	-	3814	1673	151	3363	1070
ENST00000318522	EML4	chr2	42522660	+	ENST00000389048	ALK	chr2	29446319	-	3817	1751	262	1842	526
ENST00000402711	EML4	chr2	42522660	+	ENST00000389048	ALK	chr2	29446319	-	3640	1574	259	1665	468
ENST00000401738	EML4	chr2	42522660	+	ENST00000389048	ALK	chr2	29446319	-	3739	1673	151	1764	537
ENST00000318522	EML4	chr2	42528532	+	ENST00000389048	ALK	chr2	29445266	-	3758	1903	262	2601	779
ENST00000402711	EML4	chr2	42528532	+	ENST00000389048	ALK	chr2	29445266	-	3581	1726	259	2424	721
ENST00000401738	EML4	chr2	42528532	+	ENST00000389048	ALK	chr2	29445266	-	3680	1825	151	2523	790
ENST00000318522	EML4	chr2	42552694	+	ENST00000389048	ALK	chr2	29446394	-	4645	2504	262	4194	1310
ENST00000402711	EML4	chr2	42552694	+	ENST00000389048	ALK	chr2	29446394	-	4468	2327	259	4017	1252
ENST00000401738	EML4	chr2	42552694	+	ENST00000389048	ALK	chr2	29446394	-	4567	2426	151	4116	1321
ENST00000453191	EML4	chr2	42552694	+	ENST00000389048	ALK	chr2	29446394	-	2695	554	409	2244	611
ENST00000318522	EML4	chr2	42552694	+	ENST00000389048	ALK	chr2	29449940	-	4903	2504	262	4452	1396
ENST00000402711	EML4	chr2	42552694	+	ENST00000389048	ALK	chr2	29449940	-	4726	2327	259	4275	1338
ENST00000401738	EML4	chr2	42552694	+	ENST00000389048	ALK	chr2	29449940	-	4825	2426	151	4374	1407
ENST00000453191	EML4	chr2	42552694	+	ENST00000389048	ALK	chr2	29449940	-	2953	554	409	2502	697
ENST00000318522	EML4	chr2	42553392	+	ENST00000389048	ALK	chr2	29446394	-	4744	2603	262	4293	1343
ENST00000402711	EML4	chr2	42553392	+	ENST00000389048	ALK	chr2	29446394	-	4567	2426	259	4116	1285
ENST00000401738	EML4	chr2	42553392	+	ENST00000389048	ALK	chr2	29446394	-	4666	2525	151	4215	1354
ENST00000453191	EML4	chr2	42553392	+	ENST00000389048	ALK	chr2	29446394	-	2794	653	409	2343	644
ENST00000318522	EML4	chr2	42472827	+	ENST00000389048	ALK	chr2	29446394	-	2611	470	262	2160	632
ENST00000402711	EML4	chr2	42472827	+	ENST00000389048	ALK	chr2	29446394	-	2608	467	259	2157	632
ENST00000401738	EML4	chr2	42472827	+	ENST00000389048	ALK	chr2	29446394	-	2500	359	151	2049	632
ENST00000401738	EML4	chr2	42492091	+	ENST00000389048	ALK	chr2	29446394	-	2992	851	151	2541	796
ENST00000318522	EML4	chr2	42491871	+	ENST00000389048	ALK	chr2	29446394	-	3070	929	262	2619	785
ENST00000402711	EML4	chr2	42491871	+	ENST00000389048	ALK	chr2	29446394	-	2893	752	259	2442	727
ENST00000401738	EML4	chr2	42491871	+	ENST00000389048	ALK	chr2	29446394	-	2959	818	151	2508	785
ENST00000318522	EML4	chr2	42522656	+	ENST00000389048	ALK	chr2	29446394	-	3892	1751	262	3441	1059
ENST00000402711	EML4	chr2	42522656	+	ENST00000389048	ALK	chr2	29446394	-	3715	1574	259	3264	1001
ENST00000401738	EML4	chr2	42522656	+	ENST00000389048	ALK	chr2	29446394	-	3814	1673	151	3363	1070
ENST00000318522	EML4	chr2	42552694	+	ENST00000389048	ALK	chr2	29446394	-	4645	2504	262	4194	1310
ENST00000402711	EML4	chr2	42552694	+	ENST00000389048	ALK	chr2	29446394	-	4468	2327	259	4017	1252
ENST00000401738	EML4	chr2	42552694	+	ENST00000389048	ALK	chr2	29446394	-	4567	2426	151	4116	1321
ENST00000453191	EML4	chr2	42552694	+	ENST00000389048	ALK	chr2	29446394	-	2695	554	409	2244	611
ENST00000401738	EML4	chr2	42492091	+	ENST00000389048	ALK	chr2	29449940	-	3250	851	151	2799	882
ENST00000318522	EML4	chr2	42491871	+	ENST00000389048	ALK	chr2	29449940	-	3328	929	262	2877	871
ENST00000402711	EML4	chr2	42491871	+	ENST00000389048	ALK	chr2	29449940	-	3151	752	259	2700	813
ENST00000401738	EML4	chr2	42491871	+	ENST00000389048	ALK	chr2	29449940	-	3217	818	151	2766	871
ENST00000318522	EML4	chr2	42491871	+	ENST00000389048	ALK	chr2	29450538	-	3427	929	262	2976	904
ENST00000402711	EML4	chr2	42491871	+	ENST00000389048	ALK	chr2	29450538	-	3250	752	259	2799	846
ENST00000401738	EML4	chr2	42491871	+	ENST00000389048	ALK	chr2	29450538	-	3316	818	151	2865	904
ENST00000401738	EML4	chr2	42492091	+	ENST00000389048	ALK	chr2	29450538	-	3349	851	151	2898	915
ENST00000401738	EML4	chr2	42492090	+	ENST00000389048	ALK	chr2	29446393	-	2992	851	151	2541	796
ENST00000318522	EML4	chr2	42491870	+	ENST00000389048	ALK	chr2	29446393	-	3070	929	262	2619	785
ENST00000402711	EML4	chr2	42491870	+	ENST00000389048	ALK	chr2	29446393	-	2893	752	259	2442	727
ENST00000401738	EML4	chr2	42491870	+	ENST00000389048	ALK	chr2	29446393	-	2959	818	151	2508	785
ENST00000318522	EML4	chr2	42522655	+	ENST00000389048	ALK	chr2	29446393	-	3892	1751	262	3441	1059
ENST00000402711	EML4	chr2	42522655	+	ENST00000389048	ALK	chr2	29446393	-	3715	1574	259	3264	1001
ENST00000401738	EML4	chr2	42522655	+	ENST00000389048	ALK	chr2	29446393	-	3814	1673	151	3363	1070
ENST00000318522	EML4	chr2	42522660	+	ENST00000389048	ALK	chr2	29446396	-	3892	1751	262	3441	1059
ENST00000402711	EML4	chr2	42522660	+	ENST00000389048	ALK	chr2	29446396	-	3715	1574	259	3264	1001
ENST00000401738	EML4	chr2	42522660	+	ENST00000389048	ALK	chr2	29446396	-	3814	1673	151	3363	1070
ENST00000318522	EML4	chr2	42491871	+	ENST00000389048	ALK	chr2	29446396	-	3070	929	262	2619	785
ENST00000402711	EML4	chr2	42491871	+	ENST00000389048	ALK	chr2	29446396	-	2893	752	259	2442	727
ENST00000401738	EML4	chr2	42491871	+	ENST00000389048	ALK	chr2	29446396	-	2959	818	151	2508	785
ENST00000401738	EML4	chr2	42492091	+	ENST00000389048	ALK	chr2	29446396	-	2992	851	151	2541	796
ENST00000318522	EML4	chr2	42472827	+	ENST00000389048	ALK	chr2	29446396	-	2611	470	262	2160	632
ENST00000402711	EML4	chr2	42472827	+	ENST00000389048	ALK	chr2	29446396	-	2608	467	259	2157	632
ENST00000401738	EML4	chr2	42472827	+	ENST00000389048	ALK	chr2	29446396	-	2500	359	151	2049	632

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000318522	ENST00000389048	EML4	chr2	42472827	+	ALK	chr2	29446394	-	0.006545215	0.99345475
ENST00000402711	ENST00000389048	EML4	chr2	42472827	+	ALK	chr2	29446394	-	0.006617044	0.99338293
ENST00000401738	ENST00000389048	EML4	chr2	42472827	+	ALK	chr2	29446394	-	0.006665675	0.9933343
ENST00000401738	ENST00000389048	EML4	chr2	42492091	+	ALK	chr2	29446394	-	0.001540824	0.9984592
ENST00000318522	ENST00000389048	EML4	chr2	42491871	+	ALK	chr2	29446394	-	0.001366047	0.9986339
ENST00000402711	ENST00000389048	EML4	chr2	42491871	+	ALK	chr2	29446394	-	0.003780024	0.99622005
ENST00000401738	ENST00000389048	EML4	chr2	42491871	+	ALK	chr2	29446394	-	0.001331759	0.9986682
ENST00000318522	ENST00000389048	EML4	chr2	42522656	+	ALK	chr2	29446394	-	0.000663732	0.9993363
ENST00000402711	ENST00000389048	EML4	chr2	42522656	+	ALK	chr2	29446394	-	0.000589323	0.9994106
ENST00000401738	ENST00000389048	EML4	chr2	42522656	+	ALK	chr2	29446394	-	0.000660481	0.9993395
ENST00000318522	ENST00000389048	EML4	chr2	42552694	+	ALK	chr2	29446394	-	0.001225178	0.9987748
ENST00000402711	ENST00000389048	EML4	chr2	42552694	+	ALK	chr2	29446394	-	0.001370742	0.99862933
ENST00000401738	ENST00000389048	EML4	chr2	42552694	+	ALK	chr2	29446394	-	0.001045523	0.9989544
ENST00000453191	ENST00000389048	EML4	chr2	42552694	+	ALK	chr2	29446394	-	0.005144339	0.99485564
ENST00000401738	ENST00000389048	EML4	chr2	42492091	+	ALK	chr2	29449940	-	0.001402658	0.9985973
ENST00000318522	ENST00000389048	EML4	chr2	42491871	+	ALK	chr2	29449940	-	0.001344333	0.9986557
ENST00000402711	ENST00000389048	EML4	chr2	42491871	+	ALK	chr2	29449940	-	0.00200867	0.9979913
ENST00000401738	ENST00000389048	EML4	chr2	42491871	+	ALK	chr2	29449940	-	0.001325497	0.9986745
ENST00000318522	ENST00000389048	EML4	chr2	42491871	+	ALK	chr2	29450538	-	0.000940817	0.99905914
ENST00000402711	ENST00000389048	EML4	chr2	42491871	+	ALK	chr2	29450538	-	0.00193692	0.998063
ENST00000401738	ENST00000389048	EML4	chr2	42491871	+	ALK	chr2	29450538	-	0.000931634	0.99906844
ENST00000401738	ENST00000389048	EML4	chr2	42492091	+	ALK	chr2	29450538	-	0.000994171	0.99900585
ENST00000401738	ENST00000389048	EML4	chr2	42492090	+	ALK	chr2	29446393	-	0.001540824	0.9984592
ENST00000318522	ENST00000389048	EML4	chr2	42491870	+	ALK	chr2	29446393	-	0.001366047	0.9986339
ENST00000402711	ENST00000389048	EML4	chr2	42491870	+	ALK	chr2	29446393	-	0.003780024	0.99622005
ENST00000401738	ENST00000389048	EML4	chr2	42491870	+	ALK	chr2	29446393	-	0.001331759	0.9986682
ENST00000318522	ENST00000389048	EML4	chr2	42522655	+	ALK	chr2	29446393	-	0.000663732	0.9993363
ENST00000402711	ENST00000389048	EML4	chr2	42522655	+	ALK	chr2	29446393	-	0.000589323	0.9994106
ENST00000401738	ENST00000389048	EML4	chr2	42522655	+	ALK	chr2	29446393	-	0.000660481	0.9993395
ENST00000318522	ENST00000389048	EML4	chr2	42522660	+	ALK	chr2	29446396	-	0.000663732	0.9993363
ENST00000402711	ENST00000389048	EML4	chr2	42522660	+	ALK	chr2	29446396	-	0.000589323	0.9994106
ENST00000401738	ENST00000389048	EML4	chr2	42522660	+	ALK	chr2	29446396	-	0.000660481	0.9993395
ENST00000318522	ENST00000389048	EML4	chr2	42491871	+	ALK	chr2	29446396	-	0.001366047	0.9986339
ENST00000402711	ENST00000389048	EML4	chr2	42491871	+	ALK	chr2	29446396	-	0.003780024	0.99622005
ENST00000401738	ENST00000389048	EML4	chr2	42491871	+	ALK	chr2	29446396	-	0.001331759	0.9986682
ENST00000401738	ENST00000389048	EML4	chr2	42492091	+	ALK	chr2	29446396	-	0.001540824	0.9984592
ENST00000318522	ENST00000389048	EML4	chr2	42472827	+	ALK	chr2	29446396	-	0.006545215	0.99345475
ENST00000402711	ENST00000389048	EML4	chr2	42472827	+	ALK	chr2	29446396	-	0.006617044	0.99338293
ENST00000401738	ENST00000389048	EML4	chr2	42472827	+	ALK	chr2	29446396	-	0.006665675	0.9933343

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for EML4-ALK

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
EML4	chr2	42472827	ALK	chr2	29446394	359	69	DHVASVKKSVSSKVYRRKHQELQAMQ
EML4	chr2	42472827	ALK	chr2	29446394	467	69	DHVASVKKSVSSKVYRRKHQELQAMQ
EML4	chr2	42472827	ALK	chr2	29446394	470	69	DHVASVKKSVSSKVYRRKHQELQAMQ
EML4	chr2	42472827	ALK	chr2	29446396	359	69	DHVASVKKSVSSKVYRRKHQELQAMQ
EML4	chr2	42472827	ALK	chr2	29446396	467	69	DHVASVKKSVSSKVYRRKHQELQAMQ
EML4	chr2	42472827	ALK	chr2	29446396	470	69	DHVASVKKSVSSKVYRRKHQELQAMQ
EML4	chr2	42491870	ALK	chr2	29446393	752	164	KTADKHKDVIINQVYRRKHQELQAMQ
EML4	chr2	42491870	ALK	chr2	29446393	818	222	KTADKHKDVIINQVYRRKHQELQAMQ
EML4	chr2	42491870	ALK	chr2	29446393	929	222	KTADKHKDVIINQVYRRKHQELQAMQ
EML4	chr2	42491871	ALK	chr2	29446394	752	164	KTADKHKDVIINQVYRRKHQELQAMQ
EML4	chr2	42491871	ALK	chr2	29446394	818	222	KTADKHKDVIINQVYRRKHQELQAMQ
EML4	chr2	42491871	ALK	chr2	29446394	929	222	KTADKHKDVIINQVYRRKHQELQAMQ
EML4	chr2	42491871	ALK	chr2	29446396	752	164	KTADKHKDVIINQVYRRKHQELQAMQ
EML4	chr2	42491871	ALK	chr2	29446396	818	222	KTADKHKDVIINQVYRRKHQELQAMQ
EML4	chr2	42491871	ALK	chr2	29446396	929	222	KTADKHKDVIINQVYRRKHQELQAMQ
EML4	chr2	42491871	ALK	chr2	29449940	752	164	KTADKHKDVIINQVMEGHGEVNIKHY
EML4	chr2	42491871	ALK	chr2	29449940	818	222	KTADKHKDVIINQVMEGHGEVNIKHY
EML4	chr2	42491871	ALK	chr2	29449940	929	222	KTADKHKDVIINQVMEGHGEVNIKHY
EML4	chr2	42491871	ALK	chr2	29450538	752	164	KTADKHKDVIINQGGNAASNNDPEMD
EML4	chr2	42491871	ALK	chr2	29450538	818	222	KTADKHKDVIINQGGNAASNNDPEMD
EML4	chr2	42491871	ALK	chr2	29450538	929	222	KTADKHKDVIINQGGNAASNNDPEMD
EML4	chr2	42492090	ALK	chr2	29446393	851	233	NQAKMSTREKNSQVYRRKHQELQAMQ
EML4	chr2	42492091	ALK	chr2	29446394	851	233	NQAKMSTREKNSQVYRRKHQELQAMQ
EML4	chr2	42492091	ALK	chr2	29446396	851	233	NQAKMSTREKNSQVYRRKHQELQAMQ
EML4	chr2	42492091	ALK	chr2	29449940	851	231	IINQAKMSTREKNSQVMEGHGEVNIK
EML4	chr2	42492091	ALK	chr2	29450538	851	233	NQAKMSTREKNSQGGNAASNNDPEMD
EML4	chr2	42522655	ALK	chr2	29446393	1574	436	WSKTTVEPTPGKGPKVYRRKHQELQA
EML4	chr2	42522655	ALK	chr2	29446393	1673	505	WSKTTVEPTPGKGPKVYRRKHQELQA
EML4	chr2	42522655	ALK	chr2	29446393	1751	494	WSKTTVEPTPGKGPKVYRRKHQELQA
EML4	chr2	42522656	ALK	chr2	29446393	1574	436	WSKTTVEPTPGKGPKVYRRKHQELQA
EML4	chr2	42522656	ALK	chr2	29446393	1673	505	WSKTTVEPTPGKGPKVYRRKHQELQA
EML4	chr2	42522656	ALK	chr2	29446393	1751	494	WSKTTVEPTPGKGPKVYRRKHQELQA
EML4	chr2	42522656	ALK	chr2	29446394	1574	436	WSKTTVEPTPGKGPKVYRRKHQELQA
EML4	chr2	42522656	ALK	chr2	29446394	1673	505	WSKTTVEPTPGKGPKVYRRKHQELQA
EML4	chr2	42522656	ALK	chr2	29446394	1751	494	WSKTTVEPTPGKGPKVYRRKHQELQA
EML4	chr2	42522660	ALK	chr2	29446396	1574	436	WSKTTVEPTPGKGPKVYRRKHQELQA
EML4	chr2	42522660	ALK	chr2	29446396	1673	505	WSKTTVEPTPGKGPKVYRRKHQELQA
EML4	chr2	42522660	ALK	chr2	29446396	1751	494	WSKTTVEPTPGKGPKVYRRKHQELQA
EML4	chr2	42552694	ALK	chr2	29446394	2327	690	IMSNSGDYEILYLYRRKHQELQAMQM
EML4	chr2	42552694	ALK	chr2	29446394	2426	759	IMSNSGDYEILYLYRRKHQELQAMQM
EML4	chr2	42552694	ALK	chr2	29446394	2504	748	IMSNSGDYEILYLYRRKHQELQAMQM
EML4	chr2	42552694	ALK	chr2	29446394	554	49	IMSNSGDYEILYLYRRKHQELQAMQM
EML4	chr2	42552694	ALK	chr2	29449940	2327	690	IMSNSGDYEILYLMEGHGEVNIKHYL
EML4	chr2	42552694	ALK	chr2	29449940	2426	759	IMSNSGDYEILYLMEGHGEVNIKHYL
EML4	chr2	42552694	ALK	chr2	29449940	2504	748	IMSNSGDYEILYLMEGHGEVNIKHYL
EML4	chr2	42552694	ALK	chr2	29449940	554	49	IMSNSGDYEILYLMEGHGEVNIKHYL
EML4	chr2	42553392	ALK	chr2	29446394	2426	722	WTTYTCVLGFQVFVYRRKHQELQAMQ
EML4	chr2	42553392	ALK	chr2	29446394	2525	791	WTTYTCVLGFQVFVYRRKHQELQAMQ
EML4	chr2	42553392	ALK	chr2	29446394	2603	780	WTTYTCVLGFQVFVYRRKHQELQAMQ
EML4	chr2	42553392	ALK	chr2	29446394	653	81	WTTYTCVLGFQVFVYRRKHQELQAMQ

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Potential FusionNeoAntigen Information of EML4-ALK in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

EML4-ALK_42472827_29446394.msa
EML4-ALK_42491870_29446393.msa
EML4-ALK_42491871_29449940.msa
EML4-ALK_42492090_29446393.msa
EML4-ALK_42492091_29449940.msa
EML4-ALK_42492091_29450538.msa
EML4-ALK_42522655_29446393.msa
EML4-ALK_42552694_29446394.msa
EML4-ALK_42552694_29449940.msa
EML4-ALK_42553392_29446394.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-A30:08	KSVSSKVYR	0.9863	0.6	7	16
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-A30:08	VSSKVYRRK	0.9805	0.6802	9	18
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-A74:11	KSVSSKVYRR	0.9915	0.5095	7	17
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-A74:09	KSVSSKVYRR	0.9915	0.5095	7	17
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-A74:03	KSVSSKVYRR	0.9915	0.5095	7	17
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-B15:01	SVKKSVSSKVY	0.9997	0.7122	4	15
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-A30:08	KSVSSKVYRRK	0.9919	0.6583	7	18
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-A74:11	KKSVSSKVYRR	0.9827	0.5973	6	17
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-A74:09	KKSVSSKVYRR	0.9827	0.5973	6	17
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-A74:03	KKSVSSKVYRR	0.9827	0.5973	6	17
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-A31:01	KKSVSSKVYRR	0.9887	0.5178	6	17
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-A30:01	KSVSSKVYR	0.9882	0.7662	7	16
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-A30:01	VSSKVYRRK	0.9815	0.8265	9	18
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-B48:02	KKSVSSKVY	0.09	0.6838	6	15
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-B15:53	KKSVSSKVY	0.0822	0.6812	6	15
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-B15:54	KKSVSSKVY	0.0319	0.6723	6	15
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-A74:01	KSVSSKVYRR	0.9915	0.5095	7	17
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-B15:53	VKKSVSSKVY	0.9573	0.671	5	15
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-B15:54	VKKSVSSKVY	0.9308	0.6535	5	15
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-B15:34	SVKKSVSSKVY	0.9997	0.7122	4	15
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-B15:27	SVKKSVSSKVY	0.9997	0.6794	4	15
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-B15:33	SVKKSVSSKVY	0.9997	0.7122	4	15
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-B15:125	SVKKSVSSKVY	0.9997	0.7122	4	15
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-B15:135	SVKKSVSSKVY	0.9997	0.7197	4	15
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-B15:35	SVKKSVSSKVY	0.9996	0.6889	4	15
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-B15:50	SVKKSVSSKVY	0.9993	0.7673	4	15
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-B15:12	SVKKSVSSKVY	0.9975	0.7404	4	15
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-A30:01	KSVSSKVYRRK	0.9924	0.7958	7	18
EML4-ALK	chr2	42472827	chr2	29446394	470	HLA-A74:01	KKSVSSKVYRR	0.9827	0.5973	6	17
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-B15:02	DVIINQVY	0.9807	0.8184	7	15
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-A74:09	VIINQVYRR	0.9558	0.607	8	17
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-A74:03	VIINQVYRR	0.9558	0.607	8	17
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-A74:11	VIINQVYRR	0.9558	0.607	8	17
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-A31:02	VIINQVYRR	0.9046	0.5658	8	17
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-B15:03	KHKDVIINQVY	0.9829	0.6404	4	15
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-A74:11	KDVIINQVYRR	0.9761	0.6832	6	17
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-A74:09	KDVIINQVYRR	0.9761	0.6832	6	17
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-A74:03	KDVIINQVYRR	0.9761	0.6832	6	17
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-B15:18	KHKDVIINQVY	0.9662	0.5609	4	15
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-A31:06	KDVIINQVYRR	0.9293	0.5108	6	17
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-B15:31	DVIINQVY	0.972	0.6655	7	15
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-A31:01	VIINQVYRR	0.9611	0.5224	8	17
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-C07:46	KHKDVIINQVY	0.9911	0.7984	4	15
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-A31:01	KDVIINQVYRR	0.9862	0.6011	6	17
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-B35:24	DVIINQVY	0.9719	0.7911	7	15
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-B35:20	DVIINQVY	0.9614	0.7614	7	15
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-B35:23	DVIINQVY	0.9519	0.6958	7	15
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-B18:04	DVIINQVY	0.9463	0.8523	7	15
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-B15:08	DVIINQVY	0.9267	0.7793	7	15
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-B15:11	DVIINQVY	0.9242	0.7707	7	15
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-B35:43	DVIINQVY	0.9185	0.7732	7	15
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-B18:07	DVIINQVY	0.8746	0.7782	7	15
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-A74:01	VIINQVYRR	0.9558	0.607	8	17
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-A30:01	IINQVYRRK	0.9487	0.7847	9	18
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-B48:02	HKDVIINQVY	0.9032	0.8286	5	15
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-B15:54	KHKDVIINQVY	0.9871	0.8054	4	15
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-B15:68	KHKDVIINQVY	0.9822	0.5216	4	15
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-A74:01	KDVIINQVYRR	0.9761	0.6832	6	17
EML4-ALK	chr2	42491870	chr2	29446393	929	HLA-B48:02	KHKDVIINQVY	0.9747	0.8273	4	15
EML4-ALK	chr2	42491871	chr2	29449940	929	HLA-B39:06	HKDVIINQV	0.9938	0.7379	5	14
EML4-ALK	chr2	42491871	chr2	29449940	929	HLA-B39:01	HKDVIINQV	0.9779	0.764	5	14
EML4-ALK	chr2	42491871	chr2	29449940	929	HLA-B39:13	HKDVIINQV	0.971	0.8279	5	14
EML4-ALK	chr2	42491871	chr2	29449940	929	HLA-B38:02	HKDVIINQV	0.9288	0.9174	5	14
EML4-ALK	chr2	42491871	chr2	29449940	929	HLA-B15:10	KHKDVIINQVM	0.9884	0.6121	4	15
EML4-ALK	chr2	42491871	chr2	29449940	929	HLA-B39:05	HKDVIINQV	0.9304	0.7364	5	14
EML4-ALK	chr2	42491871	chr2	29449940	929	HLA-B39:02	HKDVIINQV	0.9884	0.8285	5	14
EML4-ALK	chr2	42491871	chr2	29449940	929	HLA-B39:31	HKDVIINQV	0.9848	0.7677	5	14
EML4-ALK	chr2	42491871	chr2	29449940	929	HLA-B39:11	HKDVIINQV	0.614	0.5548	5	14
EML4-ALK	chr2	42491871	chr2	29449940	929	HLA-B15:09	HKDVIINQV	0.6131	0.5551	5	14
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B18:01	REKNSQVY	0.9771	0.8008	7	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B15:03	REKNSQVY	0.9348	0.6984	7	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B15:18	TREKNSQVY	0.2647	0.5991	6	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B15:03	TREKNSQVY	0.236	0.6503	6	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B15:01	STREKNSQVY	0.9996	0.8384	5	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B15:25	STREKNSQVY	0.9977	0.8644	5	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B15:18	STREKNSQVY	0.8042	0.6125	5	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-A31:02	STREKNSQVYR	0.9639	0.5031	5	16
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-C07:95	TREKNSQVY	0.8545	0.5171	6	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-C07:27	TREKNSQVY	0.8294	0.8877	6	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-C07:05	TREKNSQVY	0.7001	0.8648	6	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-C07:46	TREKNSQVY	0.6824	0.7144	6	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-C07:80	TREKNSQVY	0.6643	0.8455	6	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-C07:67	TREKNSQVY	0.6643	0.8455	6	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-C07:10	TREKNSQVY	0.6373	0.8519	6	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-C12:16	TREKNSQVY	0.0154	0.8637	6	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B15:07	STREKNSQVY	0.9993	0.5685	5	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B15:53	REKNSQVY	0.9877	0.8037	7	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B18:11	REKNSQVY	0.9807	0.8229	7	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B18:06	REKNSQVY	0.9795	0.7931	7	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B15:54	REKNSQVY	0.9785	0.8025	7	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B18:05	REKNSQVY	0.9771	0.8008	7	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B15:68	REKNSQVY	0.9165	0.5481	7	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B48:02	REKNSQVY	0.751	0.8637	7	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-C07:17	TREKNSQVY	0.7719	0.8802	6	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-C07:02	TREKNSQVY	0.6643	0.8455	6	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-C07:22	TREKNSQVY	0.6496	0.529	6	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B48:02	TREKNSQVY	0.2916	0.8284	6	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-C06:06	TREKNSQVY	0.0584	0.9603	6	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B15:54	TREKNSQVY	0.0296	0.7313	6	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B15:68	TREKNSQVY	0.0117	0.5101	6	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B15:34	STREKNSQVY	0.9996	0.8384	5	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B15:33	STREKNSQVY	0.9996	0.8384	5	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B15:27	STREKNSQVY	0.9996	0.8212	5	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B15:125	STREKNSQVY	0.9996	0.8384	5	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B15:135	STREKNSQVY	0.9996	0.84	5	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B15:11	STREKNSQVY	0.9991	0.7849	5	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B15:35	STREKNSQVY	0.9991	0.7756	5	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B15:08	STREKNSQVY	0.999	0.7626	5	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B15:50	STREKNSQVY	0.9987	0.7639	5	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B15:39	STREKNSQVY	0.9973	0.7349	5	15
EML4-ALK	chr2	42492090	chr2	29446393	851	HLA-B15:12	STREKNSQVY	0.9954	0.8458	5	15
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-A30:08	STREKNSQV	0.988	0.6995	7	16
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-B39:01	TREKNSQVM	0.9877	0.8764	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-B14:01	TREKNSQVM	0.9797	0.6494	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-B14:02	TREKNSQVM	0.9797	0.6494	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-B38:02	TREKNSQVM	0.9741	0.9563	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-B38:01	TREKNSQVM	0.9713	0.9509	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-B15:10	TREKNSQVM	0.8126	0.6653	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-B15:37	TREKNSQVM	0.7448	0.6037	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-B15:18	TREKNSQVM	0.7173	0.7631	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-B39:09	TREKNSQVM	0.9908	0.7014	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-B39:12	TREKNSQVM	0.9865	0.883	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-C15:06	STREKNSQV	0.9863	0.8967	7	16
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-B39:05	TREKNSQVM	0.9674	0.871	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-C07:05	TREKNSQVM	0.9657	0.9567	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-C07:95	TREKNSQVM	0.9545	0.7175	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-C07:29	TREKNSQVM	0.9482	0.9389	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-C07:13	TREKNSQVM	0.9476	0.9168	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-C07:27	TREKNSQVM	0.9466	0.948	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-C07:46	TREKNSQVM	0.8989	0.9005	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-C12:04	STREKNSQV	0.8973	0.9873	7	16
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-C06:03	STREKNSQV	0.8927	0.9877	7	16
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-C07:80	TREKNSQVM	0.8213	0.9477	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-C07:67	TREKNSQVM	0.8213	0.9477	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-C07:19	TREKNSQVM	0.8047	0.7947	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-C07:10	TREKNSQVM	0.8027	0.9655	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-B14:03	TREKNSQVM	0.6005	0.6036	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-C12:16	TREKNSQVM	0.0804	0.9314	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-C15:02	STREKNSQV	0.9915	0.8583	7	16
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-A30:01	STREKNSQV	0.9884	0.825	7	16
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-B39:31	TREKNSQVM	0.9837	0.8779	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-B38:05	TREKNSQVM	0.9713	0.9509	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-C07:01	TREKNSQVM	0.9612	0.6908	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-C07:17	TREKNSQVM	0.9534	0.9618	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-C07:04	TREKNSQVM	0.8857	0.9518	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-C07:02	TREKNSQVM	0.8213	0.9477	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-C07:22	TREKNSQVM	0.768	0.6965	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-B39:11	TREKNSQVM	0.718	0.5898	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-C06:06	TREKNSQVM	0.6749	0.9857	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-C03:67	TREKNSQVM	0.6705	0.9813	8	17
EML4-ALK	chr2	42492091	chr2	29449940	851	HLA-B15:09	TREKNSQVM	0.6466	0.717	8	17
EML4-ALK	chr2	42492091	chr2	29450538	851	HLA-B41:01	REKNSQGGNAA	0.996	0.8025	7	18
EML4-ALK	chr2	42492091	chr2	29450538	851	HLA-B45:01	REKNSQGGNAA	0.9952	0.8767	7	18
EML4-ALK	chr2	42492091	chr2	29450538	851	HLA-B50:02	REKNSQGGNAA	0.9914	0.7448	7	18
EML4-ALK	chr2	42492091	chr2	29450538	851	HLA-B50:01	REKNSQGGNAA	0.973	0.7899	7	18
EML4-ALK	chr2	42492091	chr2	29450538	851	HLA-B40:06	REKNSQGGNAA	0.9994	0.66	7	18
EML4-ALK	chr2	42492091	chr2	29450538	851	HLA-B50:05	REKNSQGGNAA	0.973	0.7899	7	18
EML4-ALK	chr2	42492091	chr2	29450538	851	HLA-B50:04	REKNSQGGNAA	0.973	0.7899	7	18
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B35:01	TPGKGPKVY	0.9581	0.8824	8	17
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B35:08	TPGKGPKVY	0.9342	0.8505	8	17
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B15:02	TPGKGPKVY	0.8056	0.9549	8	17
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B35:05	TPGKGPKVY	0.7868	0.6598	8	17
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B53:01	TPGKGPKVY	0.5131	0.5465	8	17
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B35:08	EPTPGKGPKVY	0.9967	0.616	6	17
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B35:01	EPTPGKGPKVY	0.9958	0.6568	6	17
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B15:31	TPGKGPKVY	0.9541	0.8934	8	17
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B51:21	TPGKGPKV	0.9578	0.6149	8	16
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B51:29	TPGKGPKV	0.9571	0.5259	8	16
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B59:01	TPGKGPKV	0.8602	0.5647	8	16
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B35:77	TPGKGPKVY	0.9581	0.8824	8	17
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B35:23	TPGKGPKVY	0.954	0.8867	8	17
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B35:20	TPGKGPKVY	0.9452	0.9339	8	17
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B35:24	TPGKGPKVY	0.8864	0.8805	8	17
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B35:17	TPGKGPKVY	0.8276	0.7979	8	17
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B35:30	TPGKGPKVY	0.8276	0.7979	8	17
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B35:11	TPGKGPKVY	0.7932	0.9048	8	17
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B15:11	TPGKGPKVY	0.0931	0.8789	8	17
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B15:08	TPGKGPKVY	0.0901	0.8669	8	17
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B35:43	TPGKGPKVY	0.0799	0.8713	8	17
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B18:07	TPGKGPKVY	0.0367	0.7823	8	17
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B15:11	EPTPGKGPKVY	0.9978	0.7173	6	17
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B35:43	EPTPGKGPKVY	0.9972	0.7108	6	17
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B35:23	EPTPGKGPKVY	0.996	0.6786	6	17
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B35:77	EPTPGKGPKVY	0.9958	0.6568	6	17
EML4-ALK	chr2	42522655	chr2	29446393	1751	HLA-B35:24	EPTPGKGPKVY	0.9926	0.8053	6	17
EML4-ALK	chr2	42552694	chr2	29446394	2504	HLA-B44:03	GDYEILYLY	0.7451	0.8216	5	14
EML4-ALK	chr2	42552694	chr2	29446394	2504	HLA-B18:01	GDYEILYLY	0.7186	0.7801	5	14
EML4-ALK	chr2	42552694	chr2	29446394	2504	HLA-B08:01	YLYRRKHQEL	0.9949	0.6167	11	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	HLA-B08:09	YLYRRKHQEL	0.99	0.682	11	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	HLA-B18:04	GDYEILYLY	0.8643	0.8163	5	14
EML4-ALK	chr2	42552694	chr2	29446394	2504	HLA-B18:11	GDYEILYLY	0.8571	0.717	5	14
EML4-ALK	chr2	42552694	chr2	29446394	2504	HLA-B44:26	GDYEILYLY	0.7451	0.8216	5	14
EML4-ALK	chr2	42552694	chr2	29446394	2504	HLA-B44:13	GDYEILYLY	0.7451	0.8216	5	14
EML4-ALK	chr2	42552694	chr2	29446394	2504	HLA-B44:07	GDYEILYLY	0.7451	0.8216	5	14
EML4-ALK	chr2	42552694	chr2	29446394	2504	HLA-B18:06	GDYEILYLY	0.7278	0.7779	5	14
EML4-ALK	chr2	42552694	chr2	29446394	2504	HLA-B18:08	GDYEILYLY	0.725	0.5851	5	14
EML4-ALK	chr2	42552694	chr2	29446394	2504	HLA-B18:05	GDYEILYLY	0.7186	0.7801	5	14
EML4-ALK	chr2	42552694	chr2	29446394	2504	HLA-B18:03	GDYEILYLY	0.6886	0.7747	5	14
EML4-ALK	chr2	42552694	chr2	29446394	2504	HLA-B08:18	YLYRRKHQEL	0.9949	0.6167	11	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	HLA-B08:12	YLYRRKHQEL	0.7097	0.7039	11	21
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:22	YLMEGHGEV	0.9986	0.8219	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:24	YLMEGHGEV	0.9983	0.6795	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:60	YLMEGHGEV	0.9983	0.7236	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:67	YLMEGHGEV	0.9983	0.6795	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:30	YLMEGHGEV	0.9983	0.6795	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:11	YLMEGHGEV	0.9982	0.7121	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:27	YLMEGHGEV	0.9981	0.798	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:13	YLMEGHGEV	0.9978	0.864	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:21	YLMEGHGEV	0.9978	0.7785	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:16	YLMEGHGEV	0.9978	0.6706	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:29	YLMEGHGEV	0.9961	0.6862	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:19	YLMEGHGEV	0.9961	0.7473	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:35	YLMEGHGEV	0.9945	0.6995	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:04	YLMEGHGEV	0.9934	0.922	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:20	YLMEGHGEV	0.9923	0.6885	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:38	YLMEGHGEV	0.9908	0.7852	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:17	YLMEGHGEV	0.9849	0.889	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-B13:01	GDYEILYLM	0.7948	0.6984	5	14
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:22	YLMEGHGEVNI	0.9984	0.7103	11	22
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:24	YLMEGHGEVNI	0.9976	0.5579	11	22
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:60	YLMEGHGEVNI	0.9976	0.6105	11	22
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:30	YLMEGHGEVNI	0.9976	0.5579	11	22
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:67	YLMEGHGEVNI	0.9976	0.5579	11	22
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:11	YLMEGHGEVNI	0.9974	0.6019	11	22
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:21	YLMEGHGEVNI	0.997	0.6856	11	22
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:27	YLMEGHGEVNI	0.9964	0.6742	11	22
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:13	YLMEGHGEVNI	0.9957	0.7377	11	22
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:04	YLMEGHGEVNI	0.9947	0.7497	11	22
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:16	YLMEGHGEVNI	0.9938	0.5165	11	22
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:35	YLMEGHGEVNI	0.9892	0.6057	11	22
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:19	YLMEGHGEVNI	0.9846	0.5466	11	22
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:29	YLMEGHGEVNI	0.9731	0.5713	11	22
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:38	YLMEGHGEVNI	0.97	0.591	11	22
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:20	YLMEGHGEVNI	0.9512	0.5671	11	22
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:02	YLMEGHGEV	0.9986	0.8028	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:01	YLMEGHGEV	0.9983	0.6795	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:05	YLMEGHGEV	0.9983	0.8743	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:07	YLMEGHGEV	0.9982	0.7189	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-C04:06	YLMEGHGEV	0.9848	0.9748	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-C02:06	YLMEGHGEV	0.7959	0.9932	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-C08:13	YLMEGHGEV	0.7829	0.99	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-C08:04	YLMEGHGEV	0.7829	0.99	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-C08:03	YLMEGHGEV	0.6239	0.995	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-C01:17	YLMEGHGEV	0.5633	0.9796	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:02	YLMEGHGEVNI	0.9985	0.6264	11	22
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:01	YLMEGHGEVNI	0.9976	0.5579	11	22
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:03	YLMEGHGEV	0.999	0.8552	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:06	YLMEGHGEV	0.9978	0.7785	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:14	YLMEGHGEV	0.9977	0.7474	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-C03:06	YLMEGHGEV	0.8954	0.9955	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-C01:03	YLMEGHGEV	0.8212	0.961	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-C08:01	YLMEGHGEV	0.6239	0.995	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-C01:02	YLMEGHGEV	0.5805	0.979	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-C17:01	YLMEGHGEV	0.576	0.984	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-B07:13	YLMEGHGEV	0.2236	0.8207	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-C07:04	YLMEGHGEV	0.1895	0.9844	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-B40:21	YLMEGHGEV	0.1513	0.7295	11	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:03	ILYLMEGHGEV	0.9986	0.6707	9	20
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:14	YLMEGHGEVNI	0.9971	0.6206	11	22
EML4-ALK	chr2	42552694	chr2	29449940	2504	HLA-A02:06	YLMEGHGEVNI	0.997	0.6856	11	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	HLA-A31:02	GFQVFVYRR	0.9263	0.524	8	17
EML4-ALK	chr2	42553392	chr2	29446394	2603	HLA-B08:01	FVYRRKHQEL	0.9957	0.5101	12	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	HLA-A69:01	CVLGFQVFV	0.9802	0.7777	5	14
EML4-ALK	chr2	42553392	chr2	29446394	2603	HLA-B15:20	VLGFQVFVY	0.7439	0.9404	6	15
EML4-ALK	chr2	42553392	chr2	29446394	2603	HLA-B08:18	FVYRRKHQEL	0.9957	0.5101	12	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	HLA-A69:01	TCVLGFQVFV	0.8351	0.7603	4	14
EML4-ALK	chr2	42553392	chr2	29446394	2603	HLA-B08:12	FVYRRKHQEL	0.7942	0.6478	12	22

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Potential FusionNeoAntigen Information of EML4-ALK in HLA II

EML4-ALK_42472827_29446394.msa
EML4-ALK_42491870_29446393.msa
EML4-ALK_42491871_29449940.msa
EML4-ALK_42491871_29450538.msa
EML4-ALK_42492090_29446393.msa
EML4-ALK_42552694_29446394.msa
EML4-ALK_42553392_29446394.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0701	VASVKKSVSSKVYRR	2	17
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0701	HVASVKKSVSSKVYR	1	16
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0703	VASVKKSVSSKVYRR	2	17
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0703	HVASVKKSVSSKVYR	1	16
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0705	VASVKKSVSSKVYRR	2	17
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0705	HVASVKKSVSSKVYR	1	16
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0706	VASVKKSVSSKVYRR	2	17
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0707	VASVKKSVSSKVYRR	2	17
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0707	HVASVKKSVSSKVYR	1	16
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0708	VASVKKSVSSKVYRR	2	17
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0708	HVASVKKSVSSKVYR	1	16
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0709	VASVKKSVSSKVYRR	2	17
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0712	VASVKKSVSSKVYRR	2	17
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0712	HVASVKKSVSSKVYR	1	16
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0713	VASVKKSVSSKVYRR	2	17
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0713	HVASVKKSVSSKVYR	1	16
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0714	VASVKKSVSSKVYRR	2	17
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0714	HVASVKKSVSSKVYR	1	16
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0715	VASVKKSVSSKVYRR	2	17
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0715	HVASVKKSVSSKVYR	1	16
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0716	VASVKKSVSSKVYRR	2	17
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0716	HVASVKKSVSSKVYR	1	16
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0717	VASVKKSVSSKVYRR	2	17
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0717	HVASVKKSVSSKVYR	1	16
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0719	VASVKKSVSSKVYRR	2	17
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0719	HVASVKKSVSSKVYR	1	16
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0802	SKVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0809	SKVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0815	SKVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0821	SKVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0830	SKVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0906	VASVKKSVSSKVYRR	2	17
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-0906	HVASVKKSVSSKVYR	1	16
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-1403	SKVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-1427	SKVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-1427	SSKVYRRKHQELQAM	10	25
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-1440	SKVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-1467	SKVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42472827	chr2	29446394	470	DRB1-1477	SKVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0303	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0303	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0303	DKHKDVIINQVYRRK	3	18
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0303	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0303	ADKHKDVIINQVYRR	2	17
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0307	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0307	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0307	DKHKDVIINQVYRRK	3	18
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0307	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0315	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0320	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0324	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0324	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0324	DKHKDVIINQVYRRK	3	18
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0324	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0326	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0338	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0338	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0340	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0340	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0342	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0342	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0802	NQVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0808	NQVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0809	NQVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0811	NQVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0815	NQVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0821	NQVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-0830	NQVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1102	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1103	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1103	DVIINQVYRRKHQEL	7	22
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1106	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1107	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1107	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1107	DKHKDVIINQVYRRK	3	18
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1107	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1114	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1114	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1116	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1120	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1120	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1121	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1121	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1121	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1134	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1136	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1136	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1141	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1147	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1148	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1148	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1154	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1155	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1157	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1159	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1159	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1159	DVIINQVYRRKHQEL	7	22
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1163	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1163	DVIINQVYRRKHQEL	7	22
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1165	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1168	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1176	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1176	DVIINQVYRRKHQEL	7	22
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1182	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1185	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1185	DVIINQVYRRKHQEL	7	22
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1186	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1186	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1186	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1192	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1204	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1209	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1301	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1302	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1302	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1308	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1308	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1309	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1309	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1315	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1315	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1316	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1316	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1316	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1317	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1317	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1319	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1319	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1319	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1320	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1320	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1322	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1323	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1323	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1324	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1324	DVIINQVYRRKHQEL	7	22
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1327	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1327	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1327	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1329	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1334	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1334	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1335	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1336	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1339	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1339	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1341	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1341	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1344	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1351	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1352	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1353	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1353	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1353	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1357	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1357	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1359	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1361	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1361	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1361	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1361	DKHKDVIINQVYRRK	3	18
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1364	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1367	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1368	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1369	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1370	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1370	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1371	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1371	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1371	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1372	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1372	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1373	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1373	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1374	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1374	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1375	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1376	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1376	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1378	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1378	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1379	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1380	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1383	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1384	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1384	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1385	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1386	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1386	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1387	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1391	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1392	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1396	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1396	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1396	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1396	DKHKDVIINQVYRRK	3	18
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1397	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1397	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1398	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1399	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1399	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1402	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1402	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1403	NQVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1406	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1406	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1406	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1406	DKHKDVIINQVYRRK	3	18
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1412	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1412	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1417	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1418	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1419	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1419	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1419	DKHKDVIINQVYRRK	3	18
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1419	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1420	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1420	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1420	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1420	DKHKDVIINQVYRRK	3	18
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1421	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1421	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1424	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1424	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1424	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1424	DKHKDVIINQVYRRK	3	18
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1427	NQVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1429	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1429	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1429	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1429	DKHKDVIINQVYRRK	3	18
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1437	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1437	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1437	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1440	NQVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1441	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1441	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1446	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1447	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1447	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1447	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1447	DKHKDVIINQVYRRK	3	18
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1451	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1452	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1452	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1452	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1452	DKHKDVIINQVYRRK	3	18
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1467	NQVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1476	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1477	NQVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1479	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1480	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1481	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1481	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1481	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1483	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1483	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1483	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1483	DKHKDVIINQVYRRK	3	18
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1489	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1489	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1494	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1494	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1498	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1498	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1498	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB1-1498	DKHKDVIINQVYRRK	3	18
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB3-0201	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB3-0201	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB3-0204	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB3-0204	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB3-0204	DKHKDVIINQVYRRK	3	18
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB3-0204	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB3-0205	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB3-0214	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB3-0219	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB3-0222	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB3-0224	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB3-0224	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB5-0106	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB5-0106	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB5-0106	KDVIINQVYRRKHQE	6	21
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB5-0106	DKHKDVIINQVYRRK	3	18
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB5-0111	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB5-0202	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB5-0204	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB5-0204	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB5-0205	HKDVIINQVYRRKHQ	5	20
EML4-ALK	chr2	42491870	chr2	29446393	929	DRB5-0205	KHKDVIINQVYRRKH	4	19
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB1-1447	HKDVIINQVMEGHGE	5	20
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB3-0201	HKDVIINQVMEGHGE	5	20
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB3-0201	KHKDVIINQVMEGHG	4	19
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB3-0201	KDVIINQVMEGHGEV	6	21
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB3-0202	HKDVIINQVMEGHGE	5	20
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB3-0204	HKDVIINQVMEGHGE	5	20
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB3-0204	KHKDVIINQVMEGHG	4	19
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB3-0205	HKDVIINQVMEGHGE	5	20
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB3-0205	KHKDVIINQVMEGHG	4	19
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB3-0210	HKDVIINQVMEGHGE	5	20
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB3-0211	HKDVIINQVMEGHGE	5	20
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB3-0212	HKDVIINQVMEGHGE	5	20
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB3-0213	HKDVIINQVMEGHGE	5	20
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB3-0214	HKDVIINQVMEGHGE	5	20
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB3-0214	KHKDVIINQVMEGHG	4	19
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB3-0215	HKDVIINQVMEGHGE	5	20
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB3-0217	HKDVIINQVMEGHGE	5	20
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB3-0218	HKDVIINQVMEGHGE	5	20
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB3-0220	HKDVIINQVMEGHGE	5	20
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB3-0223	HKDVIINQVMEGHGE	5	20
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB3-0224	HKDVIINQVMEGHGE	5	20
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB3-0224	KHKDVIINQVMEGHG	4	19
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB3-0224	KDVIINQVMEGHGEV	6	21
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB3-0225	HKDVIINQVMEGHGE	5	20
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB4-0101	KDVIINQVMEGHGEV	6	21
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB4-0101	HKDVIINQVMEGHGE	5	20
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB4-0103	KDVIINQVMEGHGEV	6	21
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB4-0103	HKDVIINQVMEGHGE	5	20
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB4-0104	KDVIINQVMEGHGEV	6	21
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB4-0104	HKDVIINQVMEGHGE	5	20
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB4-0106	KDVIINQVMEGHGEV	6	21
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB4-0106	HKDVIINQVMEGHGE	5	20
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB4-0107	KDVIINQVMEGHGEV	6	21
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB4-0107	HKDVIINQVMEGHGE	5	20
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB4-0108	KDVIINQVMEGHGEV	6	21
EML4-ALK	chr2	42491871	chr2	29449940	929	DRB4-0108	HKDVIINQVMEGHGE	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-0102	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-0102	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-0109	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-0113	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-0123	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-0123	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-0413	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-0413	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-0434	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-0434	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-0437	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-0437	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-0440	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-0444	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-0444	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-0468	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-0470	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-0470	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-0473	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-0473	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-0475	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-0479	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-0479	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-1367	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-1419	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-1424	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-1446	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-1447	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-1447	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-1452	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-1489	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-1498	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB1-1525	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0201	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0201	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0201	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0201	DKHKDVIINQGGNAA	3	18
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0202	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0202	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0202	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0202	DKHKDVIINQGGNAA	3	18
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0204	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0204	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0204	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0204	DKHKDVIINQGGNAA	3	18
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0205	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0205	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0205	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0205	DKHKDVIINQGGNAA	3	18
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0209	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0209	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0210	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0210	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0210	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0210	DKHKDVIINQGGNAA	3	18
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0211	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0211	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0211	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0211	DKHKDVIINQGGNAA	3	18
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0212	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0212	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0212	DKHKDVIINQGGNAA	3	18
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0212	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0213	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0213	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0213	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0214	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0214	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0214	DKHKDVIINQGGNAA	3	18
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0214	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0215	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0215	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0215	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0216	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0216	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0217	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0217	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0217	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0217	DKHKDVIINQGGNAA	3	18
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0218	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0218	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0218	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0218	DKHKDVIINQGGNAA	3	18
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0219	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0219	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0220	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0220	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0220	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0220	DKHKDVIINQGGNAA	3	18
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0221	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0221	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0222	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0222	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0223	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0223	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0223	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0223	DKHKDVIINQGGNAA	3	18
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0224	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0224	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0224	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0224	DKHKDVIINQGGNAA	3	18
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0225	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0225	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0225	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0225	DKHKDVIINQGGNAA	3	18
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0301	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0301	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0301	DKHKDVIINQGGNAA	3	18
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0301	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0303	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB3-0303	KHKDVIINQGGNAAS	4	19
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB4-0101	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB4-0103	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB4-0104	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB4-0104	HKDVIINQGGNAASN	5	20
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB4-0106	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB4-0107	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42491871	chr2	29450538	929	DRB4-0108	KDVIINQGGNAASNN	6	21
EML4-ALK	chr2	42492090	chr2	29446393	851	DRB1-0802	SQVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42492090	chr2	29446393	851	DRB1-0809	SQVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42492090	chr2	29446393	851	DRB1-0815	SQVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42492090	chr2	29446393	851	DRB1-0821	SQVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42492090	chr2	29446393	851	DRB1-0830	SQVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42492090	chr2	29446393	851	DRB1-1427	SQVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42492090	chr2	29446393	851	DRB1-1467	SQVYRRKHQELQAMQ	11	26
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-0820	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-0828	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-0828	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-0831	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1102	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1102	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1103	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1103	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1103	YEILYLYRRKHQELQ	7	22
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1104	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1104	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1106	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1106	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1111	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1111	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1111	YEILYLYRRKHQELQ	7	22
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1111	EILYLYRRKHQELQA	8	23
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1116	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1116	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1118	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1118	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1121	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1121	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1125	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1125	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1135	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1135	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1136	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1136	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1138	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1138	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1141	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1141	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1142	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1142	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1143	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1143	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1144	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1144	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1146	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1146	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1147	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1147	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1148	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1148	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1150	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1154	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1154	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1155	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1155	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1155	YEILYLYRRKHQELQ	7	22
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1156	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1157	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1157	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1158	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1158	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1159	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1159	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1160	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1160	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1163	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1163	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1163	YEILYLYRRKHQELQ	7	22
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1165	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1165	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1167	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1167	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1170	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1170	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1170	YEILYLYRRKHQELQ	7	22
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1172	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1172	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1172	SGDYEILYLYRRKHQ	4	19
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1176	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1176	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1176	YEILYLYRRKHQELQ	7	22
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1177	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1177	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1178	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1178	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1184	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1184	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1185	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1185	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1185	YEILYLYRRKHQELQ	7	22
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1186	YEILYLYRRKHQELQ	7	22
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1186	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1188	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1192	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1192	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1192	SGDYEILYLYRRKHQ	4	19
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1204	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1204	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1204	SGDYEILYLYRRKHQ	4	19
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1209	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1209	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1209	SGDYEILYLYRRKHQ	4	19
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1301	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1301	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1304	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1304	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1306	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1306	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1308	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1308	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1309	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1311	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1311	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1315	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1315	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1315	YEILYLYRRKHQELQ	7	22
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1316	YEILYLYRRKHQELQ	7	22
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1316	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1317	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1317	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1317	YEILYLYRRKHQELQ	7	22
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1318	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1318	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1319	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1319	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1319	YEILYLYRRKHQELQ	7	22
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1320	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1320	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1322	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1322	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1324	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1324	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1324	YEILYLYRRKHQELQ	7	22
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1327	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1327	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1335	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1335	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1338	EILYLYRRKHQELQA	8	23
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1338	YEILYLYRRKHQELQ	7	22
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1338	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1342	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1342	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1351	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1351	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1352	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1352	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1353	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1353	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1353	YEILYLYRRKHQELQ	7	22
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1354	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1357	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1357	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1357	YEILYLYRRKHQELQ	7	22
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1359	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1359	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1363	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1363	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1363	YEILYLYRRKHQELQ	7	22
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1363	EILYLYRRKHQELQA	8	23
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1364	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1364	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1365	EILYLYRRKHQELQA	8	23
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1365	YEILYLYRRKHQELQ	7	22
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1365	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1368	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1368	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1369	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1369	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1370	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1370	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1371	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1371	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1372	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1372	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1375	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1375	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1375	YEILYLYRRKHQELQ	7	22
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1378	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1378	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1379	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1379	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1380	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1380	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1383	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1383	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1384	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1384	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1387	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1387	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1391	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1391	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1392	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1392	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1393	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1393	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1398	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1398	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1412	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1412	DYEILYLYRRKHQEL	6	21
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB1-1478	GDYEILYLYRRKHQE	5	20
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB5-0102	SGDYEILYLYRRKHQ	4	19
EML4-ALK	chr2	42552694	chr2	29446394	2504	DRB5-0108N	SGDYEILYLYRRKHQ	4	19
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-0837	FQVFVYRRKHQELQA	9	24
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-0837	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1102	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1102	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1103	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1103	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1111	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1111	FQVFVYRRKHQELQA	9	24
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1111	QVFVYRRKHQELQAM	10	25
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1111	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1114	FQVFVYRRKHQELQA	9	24
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1114	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1116	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1116	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1120	FQVFVYRRKHQELQA	9	24
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1120	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1121	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1136	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1148	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1155	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1155	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1155	VLGFQVFVYRRKHQE	6	21
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1159	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1163	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1163	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1165	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1165	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1168	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1168	FQVFVYRRKHQELQA	9	24
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1170	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1170	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1170	VLGFQVFVYRRKHQE	6	21
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1176	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1176	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1185	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1185	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1186	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1186	FQVFVYRRKHQELQA	9	24
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1186	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1186	QVFVYRRKHQELQAM	10	25
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1301	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1301	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1302	FQVFVYRRKHQELQA	9	24
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1302	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1304	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1304	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1304	VLGFQVFVYRRKHQE	6	21
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1308	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1309	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1315	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1315	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1315	VLGFQVFVYRRKHQE	6	21
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1316	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1316	FQVFVYRRKHQELQA	9	24
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1316	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1316	QVFVYRRKHQELQAM	10	25
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1317	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1317	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1319	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1319	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1320	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1322	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1322	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1323	FQVFVYRRKHQELQA	9	24
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1323	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1324	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1324	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1329	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1329	FQVFVYRRKHQELQA	9	24
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1332	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1334	FQVFVYRRKHQELQA	9	24
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1334	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1335	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1335	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1336	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1336	FQVFVYRRKHQELQA	9	24
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1338	FQVFVYRRKHQELQA	9	24
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1338	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1338	QVFVYRRKHQELQAM	10	25
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1338	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1339	FQVFVYRRKHQELQA	9	24
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1339	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1348	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1351	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1351	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1352	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1352	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1353	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1353	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1354	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1357	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1357	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1357	VLGFQVFVYRRKHQE	6	21
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1359	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1359	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1361	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1363	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1363	FQVFVYRRKHQELQA	9	24
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1363	QVFVYRRKHQELQAM	10	25
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1363	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1364	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1364	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1365	FQVFVYRRKHQELQA	9	24
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1365	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1365	QVFVYRRKHQELQAM	10	25
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1365	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1368	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1368	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1369	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1369	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1370	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1372	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1373	FQVFVYRRKHQELQA	9	24
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1373	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1374	FQVFVYRRKHQELQA	9	24
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1374	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1375	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1375	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1375	FQVFVYRRKHQELQA	9	24
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1375	VLGFQVFVYRRKHQE	6	21
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1376	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1378	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1379	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1379	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1380	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1380	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1383	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1383	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1384	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1387	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1387	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1391	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1391	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1392	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1392	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1393	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1393	LGFQVFVYRRKHQEL	7	22
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1393	VLGFQVFVYRRKHQE	6	21
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1397	FQVFVYRRKHQELQA	9	24
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1397	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1398	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1399	FQVFVYRRKHQELQA	9	24
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1399	GFQVFVYRRKHQELQ	8	23
EML4-ALK	chr2	42553392	chr2	29446394	2603	DRB1-1463	FQVFVYRRKHQELQA	9	24

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Fusion breakpoint peptide structures of EML4-ALK

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
1486	DYEILYLMEGHGEV	EML4	ALK	chr2	42552694	chr2	29449940	2504

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
1487	DYEILYLYRRKHQE	EML4	ALK	chr2	42552694	chr2	29446394	2504

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
2026	EPTPGKGPKVYRRK	EML4	ALK	chr2	42522655	chr2	29446393	1751

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
4171	KDVIINQVMEGHGE	EML4	ALK	chr2	42491871	chr2	29449940	929

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
4172	KDVIINQVYRRKHQ	EML4	ALK	chr2	42491870	chr2	29446393	929

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
4359	KKSVSSKVYRRKHQ	EML4	ALK	chr2	42472827	chr2	29446394	470

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
6023	MSTREKNSQVMEGH	EML4	ALK	chr2	42492091	chr2	29449940	851

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
9594	TREKNSQGGNAASN	EML4	ALK	chr2	42492091	chr2	29450538	851

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
9595	TREKNSQVYRRKHQ	EML4	ALK	chr2	42492090	chr2	29446393	851

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
10072	VLGFQVFVYRRKHQ	EML4	ALK	chr2	42553392	chr2	29446394	2603

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of EML4-ALK

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	1486	DYEILYLMEGHGEV	-7.15543	-7.26883
HLA-B14:02	3BVN	1486	DYEILYLMEGHGEV	-4.77435	-5.80965
HLA-B52:01	3W39	1486	DYEILYLMEGHGEV	-6.80875	-6.92215
HLA-B52:01	3W39	1486	DYEILYLMEGHGEV	-4.20386	-5.23916
HLA-A11:01	4UQ2	1486	DYEILYLMEGHGEV	-7.5194	-8.5547
HLA-A11:01	4UQ2	1486	DYEILYLMEGHGEV	-6.9601	-7.0735
HLA-A24:02	5HGA	1486	DYEILYLMEGHGEV	-7.52403	-7.63743
HLA-A24:02	5HGA	1486	DYEILYLMEGHGEV	-5.82433	-6.85963
HLA-B27:05	6PYJ	1486	DYEILYLMEGHGEV	-3.28285	-4.31815
HLA-B44:05	3DX8	1486	DYEILYLMEGHGEV	-5.91172	-6.94702
HLA-B44:05	3DX8	1486	DYEILYLMEGHGEV	-4.24346	-4.35686
HLA-B14:02	3BVN	1487	DYEILYLYRRKHQE	-7.15543	-7.26883
HLA-B14:02	3BVN	1487	DYEILYLYRRKHQE	-4.77435	-5.80965
HLA-B52:01	3W39	1487	DYEILYLYRRKHQE	-6.80875	-6.92215
HLA-B52:01	3W39	1487	DYEILYLYRRKHQE	-4.20386	-5.23916
HLA-A11:01	4UQ2	1487	DYEILYLYRRKHQE	-7.5194	-8.5547
HLA-A11:01	4UQ2	1487	DYEILYLYRRKHQE	-6.9601	-7.0735
HLA-A24:02	5HGA	1487	DYEILYLYRRKHQE	-7.52403	-7.63743
HLA-A24:02	5HGA	1487	DYEILYLYRRKHQE	-5.82433	-6.85963
HLA-B27:05	6PYJ	1487	DYEILYLYRRKHQE	-3.28285	-4.31815
HLA-B44:05	3DX8	1487	DYEILYLYRRKHQE	-5.91172	-6.94702
HLA-B44:05	3DX8	1487	DYEILYLYRRKHQE	-4.24346	-4.35686
HLA-B14:02	3BVN	2026	EPTPGKGPKVYRRK	-7.9962	-8.1096
HLA-B14:02	3BVN	2026	EPTPGKGPKVYRRK	-5.70842	-6.74372
HLA-B52:01	3W39	2026	EPTPGKGPKVYRRK	-6.83737	-6.95077
HLA-B52:01	3W39	2026	EPTPGKGPKVYRRK	-4.4836	-5.5189
HLA-A11:01	4UQ2	2026	EPTPGKGPKVYRRK	-10.0067	-10.1201
HLA-A11:01	4UQ2	2026	EPTPGKGPKVYRRK	-9.03915	-10.0745
HLA-A24:02	5HGA	2026	EPTPGKGPKVYRRK	-6.56204	-6.67544
HLA-A24:02	5HGA	2026	EPTPGKGPKVYRRK	-5.42271	-6.45801
HLA-B44:05	3DX8	2026	EPTPGKGPKVYRRK	-7.85648	-8.89178
HLA-B44:05	3DX8	2026	EPTPGKGPKVYRRK	-5.3978	-5.5112
HLA-A02:01	6TDR	2026	EPTPGKGPKVYRRK	-3.37154	-4.40684
HLA-B14:02	3BVN	4171	KDVIINQVMEGHGE	-7.15543	-7.26883
HLA-B14:02	3BVN	4171	KDVIINQVMEGHGE	-4.77435	-5.80965
HLA-B52:01	3W39	4171	KDVIINQVMEGHGE	-6.80875	-6.92215
HLA-B52:01	3W39	4171	KDVIINQVMEGHGE	-4.20386	-5.23916
HLA-A11:01	4UQ2	4171	KDVIINQVMEGHGE	-7.5194	-8.5547
HLA-A11:01	4UQ2	4171	KDVIINQVMEGHGE	-6.9601	-7.0735
HLA-A24:02	5HGA	4171	KDVIINQVMEGHGE	-7.52403	-7.63743
HLA-A24:02	5HGA	4171	KDVIINQVMEGHGE	-5.82433	-6.85963
HLA-B27:05	6PYJ	4171	KDVIINQVMEGHGE	-3.28285	-4.31815
HLA-B44:05	3DX8	4171	KDVIINQVMEGHGE	-5.91172	-6.94702
HLA-B44:05	3DX8	4171	KDVIINQVMEGHGE	-4.24346	-4.35686
HLA-B14:02	3BVN	4172	KDVIINQVYRRKHQ	-8.62545	-8.73885
HLA-B14:02	3BVN	4172	KDVIINQVYRRKHQ	-3.26321	-4.29851
HLA-B52:01	3W39	4172	KDVIINQVYRRKHQ	-6.23413	-6.34753
HLA-B52:01	3W39	4172	KDVIINQVYRRKHQ	-4.55402	-5.58932
HLA-A24:02	5HGA	4172	KDVIINQVYRRKHQ	-8.62578	-8.73918
HLA-A24:02	5HGA	4172	KDVIINQVYRRKHQ	-6.438	-7.4733
HLA-B44:05	3DX8	4172	KDVIINQVYRRKHQ	-5.68484	-5.79824
HLA-B44:05	3DX8	4172	KDVIINQVYRRKHQ	-3.64855	-4.68385
HLA-A02:01	6TDR	4172	KDVIINQVYRRKHQ	-5.14764	-6.18294
HLA-B14:02	3BVN	4359	KKSVSSKVYRRKHQ	-7.15543	-7.26883
HLA-B14:02	3BVN	4359	KKSVSSKVYRRKHQ	-4.77435	-5.80965
HLA-B52:01	3W39	4359	KKSVSSKVYRRKHQ	-6.80875	-6.92215
HLA-B52:01	3W39	4359	KKSVSSKVYRRKHQ	-4.20386	-5.23916
HLA-A11:01	4UQ2	4359	KKSVSSKVYRRKHQ	-7.5194	-8.5547
HLA-A11:01	4UQ2	4359	KKSVSSKVYRRKHQ	-6.9601	-7.0735
HLA-A24:02	5HGA	4359	KKSVSSKVYRRKHQ	-7.52403	-7.63743
HLA-A24:02	5HGA	4359	KKSVSSKVYRRKHQ	-5.82433	-6.85963
HLA-B27:05	6PYJ	4359	KKSVSSKVYRRKHQ	-3.28285	-4.31815
HLA-B44:05	3DX8	4359	KKSVSSKVYRRKHQ	-5.91172	-6.94702
HLA-B44:05	3DX8	4359	KKSVSSKVYRRKHQ	-4.24346	-4.35686
HLA-B14:02	3BVN	6023	MSTREKNSQVMEGH	-4.27183	-4.27183
HLA-A24:02	5HGA	6023	MSTREKNSQVMEGH	-5.8734	-5.8734
HLA-B14:02	3BVN	9594	TREKNSQGGNAASN	-7.15543	-7.26883
HLA-B14:02	3BVN	9594	TREKNSQGGNAASN	-4.77435	-5.80965
HLA-B52:01	3W39	9594	TREKNSQGGNAASN	-6.80875	-6.92215
HLA-B52:01	3W39	9594	TREKNSQGGNAASN	-4.20386	-5.23916
HLA-A11:01	4UQ2	9594	TREKNSQGGNAASN	-7.5194	-8.5547
HLA-A11:01	4UQ2	9594	TREKNSQGGNAASN	-6.9601	-7.0735
HLA-A24:02	5HGA	9594	TREKNSQGGNAASN	-7.52403	-7.63743
HLA-A24:02	5HGA	9594	TREKNSQGGNAASN	-5.82433	-6.85963
HLA-B27:05	6PYJ	9594	TREKNSQGGNAASN	-3.28285	-4.31815
HLA-B44:05	3DX8	9594	TREKNSQGGNAASN	-5.91172	-6.94702
HLA-B44:05	3DX8	9594	TREKNSQGGNAASN	-4.24346	-4.35686
HLA-B14:02	3BVN	9595	TREKNSQVYRRKHQ	-7.15543	-7.26883
HLA-B14:02	3BVN	9595	TREKNSQVYRRKHQ	-4.77435	-5.80965
HLA-B52:01	3W39	9595	TREKNSQVYRRKHQ	-6.80875	-6.92215
HLA-B52:01	3W39	9595	TREKNSQVYRRKHQ	-4.20386	-5.23916
HLA-A11:01	4UQ2	9595	TREKNSQVYRRKHQ	-7.5194	-8.5547
HLA-A11:01	4UQ2	9595	TREKNSQVYRRKHQ	-6.9601	-7.0735
HLA-A24:02	5HGA	9595	TREKNSQVYRRKHQ	-7.52403	-7.63743
HLA-A24:02	5HGA	9595	TREKNSQVYRRKHQ	-5.82433	-6.85963
HLA-B27:05	6PYJ	9595	TREKNSQVYRRKHQ	-3.28285	-4.31815
HLA-B44:05	3DX8	9595	TREKNSQVYRRKHQ	-5.91172	-6.94702
HLA-B44:05	3DX8	9595	TREKNSQVYRRKHQ	-4.24346	-4.35686
HLA-B14:02	3BVN	10072	VLGFQVFVYRRKHQ	-6.66111	-6.77451
HLA-B14:02	3BVN	10072	VLGFQVFVYRRKHQ	-6.49216	-7.52746
HLA-B52:01	3W39	10072	VLGFQVFVYRRKHQ	-5.57342	-5.68682
HLA-B52:01	3W39	10072	VLGFQVFVYRRKHQ	-3.59959	-4.63489
HLA-A11:01	4UQ2	10072	VLGFQVFVYRRKHQ	-3.54213	-3.65553
HLA-A24:02	5HGA	10072	VLGFQVFVYRRKHQ	-7.6647	-7.7781
HLA-A24:02	5HGA	10072	VLGFQVFVYRRKHQ	-4.05482	-5.09012
HLA-B44:05	3DX8	10072	VLGFQVFVYRRKHQ	-5.24587	-5.35927
HLA-B44:05	3DX8	10072	VLGFQVFVYRRKHQ	-4.91507	-5.95037
HLA-B35:01	1A1N	10072	VLGFQVFVYRRKHQ	-6.78151	-6.89491
HLA-B35:01	1A1N	10072	VLGFQVFVYRRKHQ	-5.57182	-6.60712
HLA-A02:01	6TDR	10072	VLGFQVFVYRRKHQ	-3.67735	-4.71265

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Vaccine Design for the FusionNeoAntigens of EML4-ALK

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
EML4-ALK	chr2	42472827	chr2	29446394	4	15	SVKKSVSSKVY	CAGTGAAAAAATCAGTCTCAAGTAAAGTGTACC
EML4-ALK	chr2	42472827	chr2	29446394	5	15	VKKSVSSKVY	TGAAAAAATCAGTCTCAAGTAAAGTGTACC
EML4-ALK	chr2	42472827	chr2	29446394	6	15	KKSVSSKVY	AAAAATCAGTCTCAAGTAAAGTGTACC
EML4-ALK	chr2	42472827	chr2	29446394	6	17	KKSVSSKVYRR	AAAAATCAGTCTCAAGTAAAGTGTACCGCCGGA
EML4-ALK	chr2	42472827	chr2	29446394	7	16	KSVSSKVYR	AATCAGTCTCAAGTAAAGTGTACCGCC
EML4-ALK	chr2	42472827	chr2	29446394	7	17	KSVSSKVYRR	AATCAGTCTCAAGTAAAGTGTACCGCCGGA
EML4-ALK	chr2	42472827	chr2	29446394	7	18	KSVSSKVYRRK	AATCAGTCTCAAGTAAAGTGTACCGCCGGAAGC
EML4-ALK	chr2	42472827	chr2	29446394	9	18	VSSKVYRRK	TCTCAAGTAAAGTGTACCGCCGGAAGC
EML4-ALK	chr2	42491870	chr2	29446393	4	15	KHKDVIINQVY	AGCATAAAGATGTCATCATCAACCAAGTGTACC
EML4-ALK	chr2	42491870	chr2	29446393	5	15	HKDVIINQVY	ATAAAGATGTCATCATCAACCAAGTGTACC
EML4-ALK	chr2	42491870	chr2	29446393	6	17	KDVIINQVYRR	AAGATGTCATCATCAACCAAGTGTACCGCCGGA
EML4-ALK	chr2	42491870	chr2	29446393	7	15	DVIINQVY	ATGTCATCATCAACCAAGTGTACC
EML4-ALK	chr2	42491870	chr2	29446393	8	17	VIINQVYRR	TCATCATCAACCAAGTGTACCGCCGGA
EML4-ALK	chr2	42491870	chr2	29446393	9	18	IINQVYRRK	TCATCAACCAAGTGTACCGCCGGAAGC
EML4-ALK	chr2	42491871	chr2	29449940	4	15	KHKDVIINQVM	AGCATAAAGATGTCATCATCAACCAAGTGATGG
EML4-ALK	chr2	42491871	chr2	29449940	5	14	HKDVIINQV	ATAAAGATGTCATCATCAACCAAGTGA
EML4-ALK	chr2	42492090	chr2	29446393	5	15	STREKNSQVY	CAACTCGCGAAAAAAACAGCCAAGTGTACC
EML4-ALK	chr2	42492090	chr2	29446393	5	16	STREKNSQVYR	CAACTCGCGAAAAAAACAGCCAAGTGTACCGCC
EML4-ALK	chr2	42492090	chr2	29446393	6	15	TREKNSQVY	CTCGCGAAAAAAACAGCCAAGTGTACC
EML4-ALK	chr2	42492090	chr2	29446393	7	15	REKNSQVY	GCGAAAAAAACAGCCAAGTGTACC
EML4-ALK	chr2	42492091	chr2	29449940	7	16	STREKNSQV	GCGAAAAAAACAGCCAAGTGATGGAAG
EML4-ALK	chr2	42492091	chr2	29449940	8	17	TREKNSQVM	AAAAAAACAGCCAAGTGATGGAAGGCC
EML4-ALK	chr2	42492091	chr2	29450538	7	18	REKNSQGGNAA	GCGAAAAAAACAGCCAAGGCGGCAATGCAGCCT
EML4-ALK	chr2	42522655	chr2	29446393	6	17	EPTPGKGPKVY	CACCTGGGAAAGGACCTAAAGTGTACCGCCGGA
EML4-ALK	chr2	42522655	chr2	29446393	8	16	TPGKGPKV	GGAAAGGACCTAAAGTGTACCGCC
EML4-ALK	chr2	42522655	chr2	29446393	8	17	TPGKGPKVY	GGAAAGGACCTAAAGTGTACCGCCGGA
EML4-ALK	chr2	42552694	chr2	29446394	11	21	YLYRRKHQEL	TGTACTTGTACCGCCGGAAGCACCAGGAGC
EML4-ALK	chr2	42552694	chr2	29446394	5	14	GDYEILYLY	CGGGAGACTATGAAATATTGTACTTGT
EML4-ALK	chr2	42552694	chr2	29449940	11	20	YLMEGHGEV	TGTACTTGATGGAAGGCCACGGGGAAG
EML4-ALK	chr2	42552694	chr2	29449940	11	22	YLMEGHGEVNI	TGTACTTGATGGAAGGCCACGGGGAAGTGAATA
EML4-ALK	chr2	42552694	chr2	29449940	5	14	GDYEILYLM	CGGGAGACTATGAAATATTGTACTTGA
EML4-ALK	chr2	42552694	chr2	29449940	9	20	ILYLMEGHGEV	AAATATTGTACTTGATGGAAGGCCACGGGGAAG
EML4-ALK	chr2	42553392	chr2	29446394	12	22	FVYRRKHQEL	TTGTGTACCGCCGGAAGCACCAGGAGCTGC
EML4-ALK	chr2	42553392	chr2	29446394	4	14	TCVLGFQVFV	CCTGTGTGCTAGGATTTCAAGTATTTGTGT
EML4-ALK	chr2	42553392	chr2	29446394	5	14	CVLGFQVFV	GTGTGCTAGGATTTCAAGTATTTGTGT
EML4-ALK	chr2	42553392	chr2	29446394	6	15	VLGFQVFVY	TGCTAGGATTTCAAGTATTTGTGTACC
EML4-ALK	chr2	42553392	chr2	29446394	8	17	GFQVFVYRR	GATTTCAAGTATTTGTGTACCGCCGGA

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
EML4-ALK	chr2	42472827	chr2	29446394	1	16	HVASVKKSVSSKVYR	ATGTGGCCTCAGTGAAAAAATCAGTCTCAAGTAAAGTGTACCGCC
EML4-ALK	chr2	42472827	chr2	29446394	10	25	SSKVYRRKHQELQAM	CAAGTAAAGTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATGC
EML4-ALK	chr2	42472827	chr2	29446394	11	26	SKVYRRKHQELQAMQ	GTAAAGTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATGCAGA
EML4-ALK	chr2	42472827	chr2	29446394	2	17	VASVKKSVSSKVYRR	TGGCCTCAGTGAAAAAATCAGTCTCAAGTAAAGTGTACCGCCGGA
EML4-ALK	chr2	42491870	chr2	29446393	11	26	NQVYRRKHQELQAMQ	ACCAAGTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATGCAGA
EML4-ALK	chr2	42491870	chr2	29446393	2	17	ADKHKDVIINQVYRR	CAGACAAGCATAAAGATGTCATCATCAACCAAGTGTACCGCCGGA
EML4-ALK	chr2	42491870	chr2	29446393	3	18	DKHKDVIINQVYRRK	ACAAGCATAAAGATGTCATCATCAACCAAGTGTACCGCCGGAAGC
EML4-ALK	chr2	42491870	chr2	29446393	4	19	KHKDVIINQVYRRKH	AGCATAAAGATGTCATCATCAACCAAGTGTACCGCCGGAAGCACC
EML4-ALK	chr2	42491870	chr2	29446393	5	20	HKDVIINQVYRRKHQ	ATAAAGATGTCATCATCAACCAAGTGTACCGCCGGAAGCACCAGG
EML4-ALK	chr2	42491870	chr2	29446393	6	21	KDVIINQVYRRKHQE	AAGATGTCATCATCAACCAAGTGTACCGCCGGAAGCACCAGGAGC
EML4-ALK	chr2	42491870	chr2	29446393	7	22	DVIINQVYRRKHQEL	ATGTCATCATCAACCAAGTGTACCGCCGGAAGCACCAGGAGCTGC
EML4-ALK	chr2	42491871	chr2	29449940	4	19	KHKDVIINQVMEGHG	AGCATAAAGATGTCATCATCAACCAAGTGATGGAAGGCCACGGGG
EML4-ALK	chr2	42491871	chr2	29449940	5	20	HKDVIINQVMEGHGE	ATAAAGATGTCATCATCAACCAAGTGATGGAAGGCCACGGGGAAG
EML4-ALK	chr2	42491871	chr2	29449940	6	21	KDVIINQVMEGHGEV	AAGATGTCATCATCAACCAAGTGATGGAAGGCCACGGGGAAGTGA
EML4-ALK	chr2	42491871	chr2	29450538	3	18	DKHKDVIINQGGNAA	ACAAGCATAAAGATGTCATCATCAACCAAGGCGGCAATGCAGCCT
EML4-ALK	chr2	42491871	chr2	29450538	4	19	KHKDVIINQGGNAAS	AGCATAAAGATGTCATCATCAACCAAGGCGGCAATGCAGCCTCAA
EML4-ALK	chr2	42491871	chr2	29450538	5	20	HKDVIINQGGNAASN	ATAAAGATGTCATCATCAACCAAGGCGGCAATGCAGCCTCAAACA
EML4-ALK	chr2	42491871	chr2	29450538	6	21	KDVIINQGGNAASNN	AAGATGTCATCATCAACCAAGGCGGCAATGCAGCCTCAAACAATG
EML4-ALK	chr2	42492090	chr2	29446393	11	26	SQVYRRKHQELQAMQ	GCCAAGTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATGCAGA
EML4-ALK	chr2	42552694	chr2	29446394	4	19	SGDYEILYLYRRKHQ	ACTCGGGAGACTATGAAATATTGTACTTGTACCGCCGGAAGCACC
EML4-ALK	chr2	42552694	chr2	29446394	5	20	GDYEILYLYRRKHQE	CGGGAGACTATGAAATATTGTACTTGTACCGCCGGAAGCACCAGG
EML4-ALK	chr2	42552694	chr2	29446394	6	21	DYEILYLYRRKHQEL	GAGACTATGAAATATTGTACTTGTACCGCCGGAAGCACCAGGAGC
EML4-ALK	chr2	42552694	chr2	29446394	7	22	YEILYLYRRKHQELQ	ACTATGAAATATTGTACTTGTACCGCCGGAAGCACCAGGAGCTGC
EML4-ALK	chr2	42552694	chr2	29446394	8	23	EILYLYRRKHQELQA	ATGAAATATTGTACTTGTACCGCCGGAAGCACCAGGAGCTGCAAG
EML4-ALK	chr2	42553392	chr2	29446394	10	25	QVFVYRRKHQELQAM	AAGTATTTGTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATGC
EML4-ALK	chr2	42553392	chr2	29446394	6	21	VLGFQVFVYRRKHQE	TGCTAGGATTTCAAGTATTTGTGTACCGCCGGAAGCACCAGGAGC
EML4-ALK	chr2	42553392	chr2	29446394	7	22	LGFQVFVYRRKHQEL	TAGGATTTCAAGTATTTGTGTACCGCCGGAAGCACCAGGAGCTGC
EML4-ALK	chr2	42553392	chr2	29446394	8	23	GFQVFVYRRKHQELQ	GATTTCAAGTATTTGTGTACCGCCGGAAGCACCAGGAGCTGCAAG
EML4-ALK	chr2	42553392	chr2	29446394	9	24	FQVFVYRRKHQELQA	TTCAAGTATTTGTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCA

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Information of the samples that have these potential fusion neoantigens of EML4-ALK

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
KIRP	EML4-ALK	chr2	42472827	ENST00000318522	chr2	29446394	ENST00000389048	TCGA-2Z-A9JJ-01A
LUAD	EML4-ALK	chr2	42491870	ENST00000318522	chr2	29446393	ENST00000389048	TCGA-67-6216-01A
LUAD	EML4-ALK	chr2	42522655	ENST00000318522	chr2	29446393	ENST00000389048	TCGA-78-7163-01A
LUAD	EML4-ALK	chr2	42552694	ENST00000318522	chr2	29446394	ENST00000389048	TCGA-86-A4P8-01A
THCA	EML4-ALK	chr2	42491871	ENST00000318522	chr2	29449940	ENST00000389048	TCGA-E8-A432-01A
N/A	EML4-ALK	chr2	42552694	ENST00000318522	chr2	29446394	ENST00000389048	AB275889
LUAD	EML4-ALK	chr2	42492090	ENST00000401738	chr2	29446393	ENST00000389048	TCGA-50-8460-01A
THCA	EML4-ALK	chr2	42492091	ENST00000401738	chr2	29449940	ENST00000389048	TCGA-E8-A432-01A
THCA	EML4-ALK	chr2	42492091	ENST00000401738	chr2	29450538	ENST00000389048	TCGA-E8-A432-01A

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Potential target of CAR-T therapy development for EML4-ALK

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ALK

chr2:42491871

chr2:29449940

ENST00000389048

1039_1059

1621.0

Transmembrane

Helical

Tgene

ALK

chr2:42491871

chr2:29450538

ENST00000389048

1039_1059

1621.0

Transmembrane

Helical

Tgene

ALK

chr2:42492091

chr2:29449940

ENST00000389048

1039_1059

1621.0

Transmembrane

Helical

Tgene

ALK

chr2:42492091

chr2:29450538

ENST00000389048

1039_1059

1621.0

Transmembrane

Helical

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to EML4-ALK

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Drug	Source	PMID
EML4	ALK	Crizotinib	PubMed	33157918

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Related Diseases to EML4-ALK

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
EML4	ALK	Lung Adenocarcinoma	PubMed	33157918
EML4	ALK	Lung Adenocarcinoma	MyCancerGenome
EML4	ALK	Non-Small Cell Lung Carcinoma	MyCancerGenome
EML4	ALK	Adenocarcinoma Of Unknown Primary	MyCancerGenome
EML4	ALK	Unknown	MyCancerGenome
EML4	ALK	Breast Invasive Ductal Carcinoma	MyCancerGenome

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	EML4	C0007131	Non-Small Cell Lung Carcinoma	6	CTD_human
Hgene	EML4	C0027627	Neoplasm Metastasis	2	CTD_human
Hgene	EML4	C0152013	Adenocarcinoma of lung (disorder)	2	CTD_human
Hgene	EML4	C0006118	Brain Neoplasms	1	CTD_human
Hgene	EML4	C0153633	Malignant neoplasm of brain	1	CTD_human
Hgene	EML4	C0496899	Benign neoplasm of brain, unspecified	1	CTD_human
Hgene	EML4	C0750974	Brain Tumor, Primary	1	CTD_human
Hgene	EML4	C0750977	Recurrent Brain Neoplasm	1	CTD_human
Hgene	EML4	C0750979	Primary malignant neoplasm of brain	1	CTD_human
Hgene	EML4	C1527390	Neoplasms, Intracranial	1	CTD_human
Tgene	ALK	C0007131	Non-Small Cell Lung Carcinoma	28	CGI;CTD_human
Tgene	ALK	C0027819	Neuroblastoma	13	CGI;CTD_human;ORPHANET
Tgene	ALK	C0152013	Adenocarcinoma of lung (disorder)	8	CGI;CTD_human
Tgene	ALK	C2751681	NEUROBLASTOMA, SUSCEPTIBILITY TO, 3	8	CLINGEN;UNIPROT
Tgene	ALK	C0206180	Ki-1+ Anaplastic Large Cell Lymphoma	6	CGI;CTD_human
Tgene	ALK	C0334121	Inflammatory Myofibroblastic Tumor	4	CGI;CTD_human;ORPHANET
Tgene	ALK	C0018199	Granuloma, Plasma Cell	3	CTD_human
Tgene	ALK	C0007621	Neoplastic Cell Transformation	2	CTD_human
Tgene	ALK	C0027627	Neoplasm Metastasis	2	CTD_human
Tgene	ALK	C0238463	Papillary thyroid carcinoma	2	ORPHANET
Tgene	ALK	C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET
Tgene	ALK	C0006118	Brain Neoplasms	1	CGI;CTD_human
Tgene	ALK	C0006142	Malignant neoplasm of breast	1	CTD_human
Tgene	ALK	C0007134	Renal Cell Carcinoma	1	CTD_human
Tgene	ALK	C0011570	Mental Depression	1	PSYGENET
Tgene	ALK	C0011581	Depressive disorder	1	PSYGENET
Tgene	ALK	C0027643	Neoplasm Recurrence, Local	1	CTD_human
Tgene	ALK	C0036341	Schizophrenia	1	PSYGENET
Tgene	ALK	C0079744	Diffuse Large B-Cell Lymphoma	1	CTD_human
Tgene	ALK	C0085269	Plasma Cell Granuloma, Pulmonary	1	CTD_human
Tgene	ALK	C0153633	Malignant neoplasm of brain	1	CGI;CTD_human
Tgene	ALK	C0278601	Inflammatory Breast Carcinoma	1	CTD_human
Tgene	ALK	C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	1	CTD_human
Tgene	ALK	C0496899	Benign neoplasm of brain, unspecified	1	CTD_human
Tgene	ALK	C0678222	Breast Carcinoma	1	CTD_human
Tgene	ALK	C0750974	Brain Tumor, Primary	1	CTD_human
Tgene	ALK	C0750977	Recurrent Brain Neoplasm	1	CTD_human
Tgene	ALK	C0750979	Primary malignant neoplasm of brain	1	CTD_human
Tgene	ALK	C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene	ALK	C1266042	Chromophobe Renal Cell Carcinoma	1	CTD_human
Tgene	ALK	C1266043	Sarcomatoid Renal Cell Carcinoma	1	CTD_human
Tgene	ALK	C1266044	Collecting Duct Carcinoma of the Kidney	1	CTD_human
Tgene	ALK	C1306837	Papillary Renal Cell Carcinoma	1	CTD_human
Tgene	ALK	C1332079	Anaplastic Large Cell Lymphoma, ALK-Positive	1	ORPHANET
Tgene	ALK	C1458155	Mammary Neoplasms	1	CTD_human
Tgene	ALK	C1527390	Neoplasms, Intracranial	1	CTD_human
Tgene	ALK	C2931189	Neural crest tumor	1	ORPHANET
Tgene	ALK	C3899155	hereditary neuroblastoma	1	GENOMICS_ENGLAND
Tgene	ALK	C4704874	Mammary Carcinoma, Human	1	CTD_human

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)