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Fusion Protein:ERN1-EIF3C |
Fusion Gene and Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: ERN1-EIF3C | FusionPDB ID: 27441 | FusionGDB2.0 ID: 27441 | Hgene | Tgene | Gene symbol | ERN1 | EIF3C | Gene ID | 2081 | 8663 |
| Gene name | endoplasmic reticulum to nucleus signaling 1 | eukaryotic translation initiation factor 3 subunit C | |
| Synonyms | IRE1|IRE1P|IRE1a|hIRE1p | EIF3CL|EIF3S8|eIF3-p110 | |
| Cytomap | 17q23.3 | 16p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase/endoribonuclease IRE1ER to nucleus signalling 1inositol-requiring 1inositol-requiring enzyme 1inositol-requiring protein 1ire1-alphaprotein kinase/endoribonuclease | eukaryotic translation initiation factor 3 subunit Ccell migration-inducing protein 17eIF3 p110eukaryotic translation initiation factor 3 subunit 8eukaryotic translation initiation factor 3, subunit 8 (110kD)eukaryotic translation initiation factor 3 | |
| Modification date | 20200329 | 20200322 | |
| UniProtAcc | O75460 Main function of 5'-partner protein: FUNCTION: Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11779464, PubMed:11175748, PubMed:12637535, PubMed:9637683, PubMed:21317875, PubMed:28128204). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded proteins in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:24508390, PubMed:21317875). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:24508390, PubMed:21317875). Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed:21884936, PubMed:28067262). {ECO:0000269|PubMed:11175748, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:12637535, ECO:0000269|PubMed:21317875, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28128204, ECO:0000269|PubMed:9637683, ECO:0000305|PubMed:24508390}. | B5ME19 Main function of 5'-partner protein: FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}. | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000433197, ENST00000577567, ENST00000606895, | ENST00000565099, ENST00000331666, ENST00000395587, ENST00000564243, ENST00000566501, ENST00000566866, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 7 X 9 X 7=441 | 8 X 8 X 3=192 |
| # samples | 10 | 8 | |
| ** MAII score | log2(10/441*10)=-2.1407786557828 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Fusion gene context | PubMed: ERN1 [Title/Abstract] AND EIF3C [Title/Abstract] AND fusion [Title/Abstract] | ||
| Fusion neoantigen context | PubMed: ERN1 [Title/Abstract] AND EIF3C [Title/Abstract] AND neoantigen [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ERN1(62144031)-EIF3C(28734485), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ERN1-EIF3C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ERN1-EIF3C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ERN1-EIF3C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ERN1-EIF3C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ERN1 | GO:0001935 | endothelial cell proliferation | 23529610 |
| Hgene | ERN1 | GO:0006468 | protein phosphorylation | 9637683 |
| Hgene | ERN1 | GO:0007257 | activation of JUN kinase activity | 10650002 |
| Hgene | ERN1 | GO:0033120 | positive regulation of RNA splicing | 11779464|19622636 |
| Hgene | ERN1 | GO:0034620 | cellular response to unfolded protein | 19328063 |
| Hgene | ERN1 | GO:0034976 | response to endoplasmic reticulum stress | 10650002 |
| Hgene | ERN1 | GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 23529610 |
| Hgene | ERN1 | GO:0036289 | peptidyl-serine autophosphorylation | 20103773 |
| Hgene | ERN1 | GO:0036498 | IRE1-mediated unfolded protein response | 9637683|11779465|19328063|29198525 |
| Hgene | ERN1 | GO:0046777 | protein autophosphorylation | 9637683|19328063 |
| Hgene | ERN1 | GO:0070054 | mRNA splicing, via endonucleolytic cleavage and ligation | 11779464|19328063|19622636|21317875 |
| Hgene | ERN1 | GO:0071333 | cellular response to glucose stimulus | 20103773 |
| Hgene | ERN1 | GO:0098787 | mRNA cleavage involved in mRNA processing | 21317875 |
| Hgene | ERN1 | GO:1901142 | insulin metabolic process | 20103773 |
| Tgene | EIF3C | GO:0006413 | translational initiation | 17581632 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:62144031/chr16:28734485) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here. |
| Fusion gene breakpoints across ERN1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across EIF3C (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Amino Acid Sequences |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000433197 | ERN1 | chr17 | 62144031 | - | ENST00000566501 | EIF3C | chr16 | 28734485 | + | 2989 | 938 | 27 | 2903 | 958 |
| ENST00000433197 | ERN1 | chr17 | 62144031 | - | ENST00000331666 | EIF3C | chr16 | 28734485 | + | 3121 | 938 | 27 | 2903 | 958 |
| ENST00000433197 | ERN1 | chr17 | 62144031 | - | ENST00000395587 | EIF3C | chr16 | 28734485 | + | 3118 | 938 | 27 | 2903 | 958 |
| ENST00000433197 | ERN1 | chr17 | 62144031 | - | ENST00000564243 | EIF3C | chr16 | 28734485 | + | 2987 | 938 | 27 | 2903 | 958 |
| ENST00000433197 | ERN1 | chr17 | 62144031 | - | ENST00000566866 | EIF3C | chr16 | 28734485 | + | 2988 | 938 | 27 | 2903 | 958 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000433197 | ENST00000566501 | ERN1 | chr17 | 62144031 | - | EIF3C | chr16 | 28734485 | + | 0.001573235 | 0.9984268 |
| ENST00000433197 | ENST00000331666 | ERN1 | chr17 | 62144031 | - | EIF3C | chr16 | 28734485 | + | 0.00154331 | 0.9984567 |
| ENST00000433197 | ENST00000395587 | ERN1 | chr17 | 62144031 | - | EIF3C | chr16 | 28734485 | + | 0.001554107 | 0.9984459 |
| ENST00000433197 | ENST00000564243 | ERN1 | chr17 | 62144031 | - | EIF3C | chr16 | 28734485 | + | 0.001586165 | 0.9984138 |
| ENST00000433197 | ENST00000566866 | ERN1 | chr17 | 62144031 | - | EIF3C | chr16 | 28734485 | + | 0.001590474 | 0.99840957 |
| Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones. |
Get the fusion protein sequences from here. |
| Fusion protein sequence information is available in the fasta format. >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP |
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Fusion Protein Breakpoint Sequences for ERN1-EIF3C |
| +/-13 AA sequence from the breakpoints of the fusion protein sequences. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Length(fusion protein) | BP in fusion protein | Peptide |
| ERN1 | chr17 | 62144031 | EIF3C | chr16 | 28734485 | 938 | 304 | PFPKETEAKSKLTAPTTDEDKKAAEK |
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Potential FusionNeoAntigen Information of ERN1-EIF3C in HLA I |
| Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific. |
| ERN1-EIF3C_62144031_28734485.msa |
| Potential FusionNeoAntigen Information * We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5) |
| Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA I | FusionNeoAntigen peptide | Binding score | Immunogenic score | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 | HLA-B45:01 | TEAKSKLTA | 0.9971 | 0.8273 | 5 | 14 |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 | HLA-B50:02 | TEAKSKLTA | 0.9937 | 0.7187 | 5 | 14 |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 | HLA-A30:08 | KSKLTAPTT | 0.9792 | 0.8643 | 8 | 17 |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 | HLA-B08:09 | EAKSKLTAP | 0.969 | 0.501 | 6 | 15 |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 | HLA-B41:01 | TEAKSKLTA | 0.6667 | 0.7162 | 5 | 14 |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 | HLA-B50:01 | TEAKSKLTA | 0.2448 | 0.7303 | 5 | 14 |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 | HLA-B45:01 | TEAKSKLTAP | 0.9734 | 0.8796 | 5 | 15 |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 | HLA-B41:01 | TEAKSKLTAP | 0.9182 | 0.7385 | 5 | 15 |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 | HLA-B50:02 | TEAKSKLTAP | 0.8931 | 0.7254 | 5 | 15 |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 | HLA-B41:01 | ETEAKSKLTA | 0.7805 | 0.7989 | 4 | 14 |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 | HLA-B45:01 | ETEAKSKLTA | 0.7448 | 0.896 | 4 | 14 |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 | HLA-B50:02 | ETEAKSKLTA | 0.7298 | 0.6721 | 4 | 14 |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 | HLA-B45:01 | KETEAKSKLTA | 0.9996 | 0.8721 | 3 | 14 |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 | HLA-B50:02 | KETEAKSKLTA | 0.9987 | 0.7195 | 3 | 14 |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 | HLA-B41:01 | KETEAKSKLTA | 0.9986 | 0.8663 | 3 | 14 |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 | HLA-B50:01 | KETEAKSKLTA | 0.9939 | 0.7585 | 3 | 14 |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 | HLA-B40:06 | TEAKSKLTA | 0.9972 | 0.5071 | 5 | 14 |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 | HLA-A30:01 | KSKLTAPTT | 0.9803 | 0.9304 | 8 | 17 |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 | HLA-B40:04 | TEAKSKLTA | 0.9497 | 0.675 | 5 | 14 |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 | HLA-B50:05 | TEAKSKLTA | 0.2448 | 0.7303 | 5 | 14 |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 | HLA-B50:04 | TEAKSKLTA | 0.2448 | 0.7303 | 5 | 14 |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 | HLA-B50:05 | KETEAKSKLTA | 0.9939 | 0.7585 | 3 | 14 |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 | HLA-B50:04 | KETEAKSKLTA | 0.9939 | 0.7585 | 3 | 14 |
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Potential FusionNeoAntigen Information of ERN1-EIF3C in HLA II |
| Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific. |
| Potential FusionNeoAntigen Information * We used NetMHCIIpan v4.1 (%rank<0.5). |
| Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA II | FusionNeoAntigen peptide | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
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Fusion breakpoint peptide structures of ERN1-EIF3C |
| 3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens * The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA. |
| File name | BPseq | Hgene | Tgene | Hchr | Hbp | Tchr | Tbp | AAlen |
| 1529 | EAKSKLTAPTTDED | ERN1 | EIF3C | chr17 | 62144031 | chr16 | 28734485 | 938 |
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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of ERN1-EIF3C |
| Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens * We used Glide to predict the interaction between HLAs and neoantigens. |
| HLA allele | PDB ID | File name | BPseq | Docking score | Glide score |
| HLA-B14:02 | 3BVN | 1529 | EAKSKLTAPTTDED | -4.49634 | -4.50354 |
| HLA-B52:01 | 3W39 | 1529 | EAKSKLTAPTTDED | -4.85976 | -4.86696 |
| HLA-A11:01 | 4UQ2 | 1529 | EAKSKLTAPTTDED | -6.83409 | -6.84129 |
| HLA-A24:02 | 5HGA | 1529 | EAKSKLTAPTTDED | -7.42139 | -7.42859 |
| HLA-B27:05 | 6PYJ | 1529 | EAKSKLTAPTTDED | -5.73102 | -5.73822 |
| HLA-B44:05 | 3DX8 | 1529 | EAKSKLTAPTTDED | -5.02455 | -5.03175 |
| HLA-A02:01 | 6TDR | 1529 | EAKSKLTAPTTDED | -6.90764 | -6.91484 |
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Vaccine Design for the FusionNeoAntigens of ERN1-EIF3C |
| mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is. |
| Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide sequence | FusionNeoAntigen RNA sequence |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 3 | 14 | KETEAKSKLTA | CAAGGAGACAGAGGCCAAGAGCAAGCTGACGGC |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 4 | 14 | ETEAKSKLTA | GGAGACAGAGGCCAAGAGCAAGCTGACGGC |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 5 | 14 | TEAKSKLTA | GACAGAGGCCAAGAGCAAGCTGACGGC |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 5 | 15 | TEAKSKLTAP | GACAGAGGCCAAGAGCAAGCTGACGGCACC |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 6 | 15 | EAKSKLTAP | AGAGGCCAAGAGCAAGCTGACGGCACC |
| ERN1-EIF3C | chr17 | 62144031 | chr16 | 28734485 | 8 | 17 | KSKLTAPTT | CAAGAGCAAGCTGACGGCACCCACCAC |
| mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs. |
| Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide | FusionNEoAntigen RNA sequence |
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Information of the samples that have these potential fusion neoantigens of ERN1-EIF3C |
| These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens. |
| Cancer type | Fusion gene | Hchr | Hbp | Henst | Tchr | Tbp | Tenst | Sample |
| BRCA | ERN1-EIF3C | chr17 | 62144031 | ENST00000433197 | chr16 | 28734485 | ENST00000331666 | TCGA-AO-A0J7-01A |
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Potential target of CAR-T therapy development for ERN1-EIF3C |
| Predicted 3D structure. We used RoseTTAFold. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features * Minus value of BPloci means that the break point is located before the CDS. |
| - In-frame and retained 'Transmembrane'. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Subcellular localization prediction of the transmembrane domain retained fusion proteins * We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image. |
| Hgene | Hchr | Hbp | Henst | Tgene | Tchr | Tbp | Tenst | DeepLoc result |
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Related Drugs to ERN1-EIF3C |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to ERN1-EIF3C |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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