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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:FMR1-FIP1L1

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FMR1-FIP1L1
FusionPDB ID: 30780
FusionGDB2.0 ID: 30780
HgeneTgene
Gene symbol

FMR1

FIP1L1

Gene ID

106478973

81608

Gene nameFMR1 intronic transcript 1factor interacting with PAPOLA and CPSF1
SynonymsFMR1FIP1|Rhe|hFip1
Cytomap

Xq27.3

4q12

Type of genencRNAprotein-coding
DescriptionFMR1 intronic transcript 1 (non-protein coding)fragile X mental retardation syndrome proteinpre-mRNA 3'-end-processing factor FIP1FIP1 like 1FIP1-like 1 proteinFIP1L1 cleavage and polyadenylation specific factor subunitfactor interacting with PAPrearranged in hypereosinophilia
Modification date2019032420200313
UniProtAcc

Q8N0W7

Main function of 5'-partner protein:

Q6UN15

Main function of 5'-partner protein: FUNCTION: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}.
Ensembl transtripts involved in fusion geneENST idsENST00000218200, ENST00000334557, 
ENST00000370470, ENST00000370471, 
ENST00000370475, ENST00000370477, 
ENST00000439526, ENST00000440235, 
ENST00000492846, 		ENST00000510668, 
ENST00000306932, ENST00000337488, 
ENST00000358575, ENST00000507166, 
ENST00000507922, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 3 X 6=12617 X 15 X 11=2805
# samples 723
** MAII scorelog2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/2805*10)=-3.60829500455178
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: FMR1 [Title/Abstract] AND FIP1L1 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: FMR1 [Title/Abstract] AND FIP1L1 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FMR1(146993748)-FIP1L1(54265896), # samples:1
Anticipated loss of major functional domain due to fusion event.FMR1-FIP1L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FMR1-FIP1L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FMR1-FIP1L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FMR1-FIP1L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:146993748/chr4:54265896)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across FMR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FIP1L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000218200FMR1chrX146993748+ENST00000507166FIP1L1chr454265896+21252801602124655
ENST00000218200FMR1chrX146993748+ENST00000358575FIP1L1chr454265896+16062801601386408
ENST00000218200FMR1chrX146993748+ENST00000337488FIP1L1chr454265896+15792801601359399
ENST00000218200FMR1chrX146993748+ENST00000507922FIP1L1chr454265896+787280160756198
ENST00000218200FMR1chrX146993748+ENST00000306932FIP1L1chr454265896+14242801601251363
ENST00000370471FMR1chrX146993748+ENST00000507166FIP1L1chr454265896+21252801602124655
ENST00000370471FMR1chrX146993748+ENST00000358575FIP1L1chr454265896+16062801601386408
ENST00000370471FMR1chrX146993748+ENST00000337488FIP1L1chr454265896+15792801601359399
ENST00000370471FMR1chrX146993748+ENST00000507922FIP1L1chr454265896+787280160756198
ENST00000370471FMR1chrX146993748+ENST00000306932FIP1L1chr454265896+14242801601251363
ENST00000370477FMR1chrX146993748+ENST00000507166FIP1L1chr454265896+21132681482112655
ENST00000370477FMR1chrX146993748+ENST00000358575FIP1L1chr454265896+15942681481374408
ENST00000370477FMR1chrX146993748+ENST00000337488FIP1L1chr454265896+15672681481347399
ENST00000370477FMR1chrX146993748+ENST00000507922FIP1L1chr454265896+775268148744198
ENST00000370477FMR1chrX146993748+ENST00000306932FIP1L1chr454265896+14122681481239363
ENST00000334557FMR1chrX146993748+ENST00000507166FIP1L1chr454265896+2024179592023655
ENST00000334557FMR1chrX146993748+ENST00000358575FIP1L1chr454265896+1505179591285408
ENST00000334557FMR1chrX146993748+ENST00000337488FIP1L1chr454265896+1478179591258399
ENST00000334557FMR1chrX146993748+ENST00000507922FIP1L1chr454265896+68617959655198
ENST00000334557FMR1chrX146993748+ENST00000306932FIP1L1chr454265896+1323179591150363
ENST00000439526FMR1chrX146993748+ENST00000507166FIP1L1chr454265896+2024179592023655
ENST00000439526FMR1chrX146993748+ENST00000358575FIP1L1chr454265896+1505179591285408
ENST00000439526FMR1chrX146993748+ENST00000337488FIP1L1chr454265896+1478179591258399
ENST00000439526FMR1chrX146993748+ENST00000507922FIP1L1chr454265896+68617959655198
ENST00000439526FMR1chrX146993748+ENST00000306932FIP1L1chr454265896+1323179591150363
ENST00000370475FMR1chrX146993748+ENST00000507166FIP1L1chr454265896+2024179592023655
ENST00000370475FMR1chrX146993748+ENST00000358575FIP1L1chr454265896+1505179591285408
ENST00000370475FMR1chrX146993748+ENST00000337488FIP1L1chr454265896+1478179591258399
ENST00000370475FMR1chrX146993748+ENST00000507922FIP1L1chr454265896+68617959655198
ENST00000370475FMR1chrX146993748+ENST00000306932FIP1L1chr454265896+1323179591150363
ENST00000370470FMR1chrX146993748+ENST00000507166FIP1L1chr454265896+18965101895631
ENST00000370470FMR1chrX146993748+ENST00000358575FIP1L1chr454265896+13775101157385
ENST00000370470FMR1chrX146993748+ENST00000337488FIP1L1chr454265896+13505101130376
ENST00000370470FMR1chrX146993748+ENST00000507922FIP1L1chr454265896+558510527175
ENST00000370470FMR1chrX146993748+ENST00000306932FIP1L1chr454265896+11955101022340

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000218200ENST00000507166FMR1chrX146993748+FIP1L1chr454265896+0.0034203360.9965797
ENST00000218200ENST00000358575FMR1chrX146993748+FIP1L1chr454265896+0.0162371940.98376274
ENST00000218200ENST00000337488FMR1chrX146993748+FIP1L1chr454265896+0.010629850.9893701
ENST00000218200ENST00000507922FMR1chrX146993748+FIP1L1chr454265896+0.0104974790.98950255
ENST00000218200ENST00000306932FMR1chrX146993748+FIP1L1chr454265896+0.0144705620.9855295
ENST00000370471ENST00000507166FMR1chrX146993748+FIP1L1chr454265896+0.0034203360.9965797
ENST00000370471ENST00000358575FMR1chrX146993748+FIP1L1chr454265896+0.0162371940.98376274
ENST00000370471ENST00000337488FMR1chrX146993748+FIP1L1chr454265896+0.010629850.9893701
ENST00000370471ENST00000507922FMR1chrX146993748+FIP1L1chr454265896+0.0104974790.98950255
ENST00000370471ENST00000306932FMR1chrX146993748+FIP1L1chr454265896+0.0144705620.9855295
ENST00000370477ENST00000507166FMR1chrX146993748+FIP1L1chr454265896+0.0036139920.99638605
ENST00000370477ENST00000358575FMR1chrX146993748+FIP1L1chr454265896+0.0171302910.9828697
ENST00000370477ENST00000337488FMR1chrX146993748+FIP1L1chr454265896+0.011311370.98868865
ENST00000370477ENST00000507922FMR1chrX146993748+FIP1L1chr454265896+0.0097179430.99028206
ENST00000370477ENST00000306932FMR1chrX146993748+FIP1L1chr454265896+0.0154121880.9845878
ENST00000334557ENST00000507166FMR1chrX146993748+FIP1L1chr454265896+0.0035605210.9964394
ENST00000334557ENST00000358575FMR1chrX146993748+FIP1L1chr454265896+0.0191014370.98089856
ENST00000334557ENST00000337488FMR1chrX146993748+FIP1L1chr454265896+0.0127179790.9872821
ENST00000334557ENST00000507922FMR1chrX146993748+FIP1L1chr454265896+0.0096415130.99035853
ENST00000334557ENST00000306932FMR1chrX146993748+FIP1L1chr454265896+0.0178687440.98213124
ENST00000439526ENST00000507166FMR1chrX146993748+FIP1L1chr454265896+0.0035605210.9964394
ENST00000439526ENST00000358575FMR1chrX146993748+FIP1L1chr454265896+0.0191014370.98089856
ENST00000439526ENST00000337488FMR1chrX146993748+FIP1L1chr454265896+0.0127179790.9872821
ENST00000439526ENST00000507922FMR1chrX146993748+FIP1L1chr454265896+0.0096415130.99035853
ENST00000439526ENST00000306932FMR1chrX146993748+FIP1L1chr454265896+0.0178687440.98213124
ENST00000370475ENST00000507166FMR1chrX146993748+FIP1L1chr454265896+0.0035605210.9964394
ENST00000370475ENST00000358575FMR1chrX146993748+FIP1L1chr454265896+0.0191014370.98089856
ENST00000370475ENST00000337488FMR1chrX146993748+FIP1L1chr454265896+0.0127179790.9872821
ENST00000370475ENST00000507922FMR1chrX146993748+FIP1L1chr454265896+0.0096415130.99035853
ENST00000370475ENST00000306932FMR1chrX146993748+FIP1L1chr454265896+0.0178687440.98213124
ENST00000370470ENST00000507166FMR1chrX146993748+FIP1L1chr454265896+0.0024599560.9975401
ENST00000370470ENST00000358575FMR1chrX146993748+FIP1L1chr454265896+0.0198632570.98013675
ENST00000370470ENST00000337488FMR1chrX146993748+FIP1L1chr454265896+0.0119886580.9880114
ENST00000370470ENST00000507922FMR1chrX146993748+FIP1L1chr454265896+0.026705790.97329426
ENST00000370470ENST00000306932FMR1chrX146993748+FIP1L1chr454265896+0.0155410880.9844589

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for FMR1-FIP1L1

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
FMR1chrX146993748FIP1L1chr45426589617937EELVVEVRGSNGAFYKVQQGRTGNSE
FMR1chrX146993748FIP1L1chr45426589626837EELVVEVRGSNGAFYKVQQGRTGNSE
FMR1chrX146993748FIP1L1chr45426589628037EELVVEVRGSNGAFYKVQQGRTGNSE
FMR1chrX146993748FIP1L1chr4542658965114EELVVEVRGSNGAFYKVQQGRTGNSE

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Potential FusionNeoAntigen Information of FMR1-FIP1L1 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
FMR1-FIP1L1_146993748_54265896.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
FMR1-FIP1L1chrX146993748chr454265896280HLA-A31:02AFYKVQQGR0.92560.56481221
FMR1-FIP1L1chrX146993748chr454265896280HLA-A33:01NGAFYKVQQGR0.97380.68271021
FMR1-FIP1L1chrX146993748chr454265896280HLA-A33:05NGAFYKVQQGR0.97380.68271021
FMR1-FIP1L1chrX146993748chr454265896280HLA-C15:06GSNGAFYKV0.99820.8642817
FMR1-FIP1L1chrX146993748chr454265896280HLA-A31:01AFYKVQQGR0.95690.511221
FMR1-FIP1L1chrX146993748chr454265896280HLA-C02:06GSNGAFYKV0.29160.9248817
FMR1-FIP1L1chrX146993748chr454265896280HLA-C15:02GSNGAFYKV0.99910.8054817
FMR1-FIP1L1chrX146993748chr454265896280HLA-C15:05GSNGAFYKV0.99880.8783817

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Potential FusionNeoAntigen Information of FMR1-FIP1L1 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
FMR1-FIP1L1_146993748_54265896.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
FMR1-FIP1L1chrX146993748chr454265896280DRB1-0103GAFYKVQQGRTGNSE1126
FMR1-FIP1L1chrX146993748chr454265896280DRB1-0103NGAFYKVQQGRTGNS1025
FMR1-FIP1L1chrX146993748chr454265896280DRB1-0109GAFYKVQQGRTGNSE1126
FMR1-FIP1L1chrX146993748chr454265896280DRB1-0109NGAFYKVQQGRTGNS1025
FMR1-FIP1L1chrX146993748chr454265896280DRB1-0111GAFYKVQQGRTGNSE1126
FMR1-FIP1L1chrX146993748chr454265896280DRB1-0115GAFYKVQQGRTGNSE1126
FMR1-FIP1L1chrX146993748chr454265896280DRB1-0115NGAFYKVQQGRTGNS1025
FMR1-FIP1L1chrX146993748chr454265896280DRB1-1130NGAFYKVQQGRTGNS1025
FMR1-FIP1L1chrX146993748chr454265896280DRB1-1130GAFYKVQQGRTGNSE1126
FMR1-FIP1L1chrX146993748chr454265896280DRB5-0102GAFYKVQQGRTGNSE1126
FMR1-FIP1L1chrX146993748chr454265896280DRB5-0103GAFYKVQQGRTGNSE1126
FMR1-FIP1L1chrX146993748chr454265896280DRB5-0108NGAFYKVQQGRTGNSE1126

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Fusion breakpoint peptide structures of FMR1-FIP1L1

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
10233VRGSNGAFYKVQQGFMR1FIP1L1chrX146993748chr454265896280

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of FMR1-FIP1L1

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN10233VRGSNGAFYKVQQG-7.15543-7.26883
HLA-B14:023BVN10233VRGSNGAFYKVQQG-4.77435-5.80965
HLA-B52:013W3910233VRGSNGAFYKVQQG-6.80875-6.92215
HLA-B52:013W3910233VRGSNGAFYKVQQG-4.20386-5.23916
HLA-A11:014UQ210233VRGSNGAFYKVQQG-7.5194-8.5547
HLA-A11:014UQ210233VRGSNGAFYKVQQG-6.9601-7.0735
HLA-A24:025HGA10233VRGSNGAFYKVQQG-7.52403-7.63743
HLA-A24:025HGA10233VRGSNGAFYKVQQG-5.82433-6.85963
HLA-B27:056PYJ10233VRGSNGAFYKVQQG-3.28285-4.31815
HLA-B44:053DX810233VRGSNGAFYKVQQG-5.91172-6.94702
HLA-B44:053DX810233VRGSNGAFYKVQQG-4.24346-4.35686
HLA-B35:011A1N10233VRGSNGAFYKVQQG-5.9251-6.0385
HLA-B35:011A1N10233VRGSNGAFYKVQQG-4.80237-5.83767

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Vaccine Design for the FusionNeoAntigens of FMR1-FIP1L1

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
FMR1-FIP1L1chrX146993748chr4542658961021NGAFYKVQQGRTTCTACAAGGTACAGCAGGGAAGAACTGGAAAC
FMR1-FIP1L1chrX146993748chr4542658961221AFYKVQQGRAAGGTACAGCAGGGAAGAACTGGAAAC
FMR1-FIP1L1chrX146993748chr454265896817GSNGAFYKVGGCGCTTTCTACAAGGTACAGCAGGGA

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
FMR1-FIP1L1chrX146993748chr4542658961025NGAFYKVQQGRTGNSTTCTACAAGGTACAGCAGGGAAGAACTGGAAACTCAGAGAAAGAA
FMR1-FIP1L1chrX146993748chr4542658961126GAFYKVQQGRTGNSETACAAGGTACAGCAGGGAAGAACTGGAAACTCAGAGAAAGAAACT

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Information of the samples that have these potential fusion neoantigens of FMR1-FIP1L1

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
HNSCFMR1-FIP1L1chrX146993748ENST00000218200chr454265896ENST00000306932TCGA-CV-A45U

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Potential target of CAR-T therapy development for FMR1-FIP1L1

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to FMR1-FIP1L1

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FMR1-FIP1L1

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource