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Fusion Protein:GLYR1-DCTN5 |
Fusion Gene and Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: GLYR1-DCTN5 | FusionPDB ID: 33429 | FusionGDB2.0 ID: 33429 | Hgene | Tgene | Gene symbol | GLYR1 | DCTN5 | Gene ID | 84656 | 84516 |
Gene name | glyoxylate reductase 1 homolog | dynactin subunit 5 | |
Synonyms | BM045|HIBDL|N-PAC|NP60|hNDF | - | |
Cytomap | 16p13.3 | 16p12.2 | |
Type of gene | protein-coding | protein-coding | |
Description | putative oxidoreductase GLYR13-hydroxyisobutyrate dehydrogenase-like proteincytokine-like nuclear factor n-pacnuclear protein 60 kDanuclear protein 60kDanuclear protein NP60nuclear protein of 60 kDanucleosome-destabilizing factor | dynactin subunit 5dynactin 4dynactin 5 (p25)dynactin subunit p25 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q49A26 Main function of 5'-partner protein: FUNCTION: Nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:29759984). Facilitates Pol II transcription through nucleosomes (PubMed:29759984). Binds DNA (in vitro) (PubMed:29759984). Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3) (PubMed:20850016). Promotes KDM1B demethylase activity (PubMed:23260659). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (PubMed:29759984). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664). Putative oxidoreductase (PubMed:23260659). {ECO:0000269|PubMed:16352664, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:29759984}. | Q9BTE1 Main function of 5'-partner protein: | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000321919, ENST00000381983, ENST00000436648, ENST00000591451, ENST00000586901, | ENST00000300087, ENST00000563998, ENST00000568272, ENST00000568589, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 8 X 10 X 6=480 | 1 X 1 X 1=1 |
# samples | 10 | 1 | |
** MAII score | log2(10/480*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Fusion gene context | PubMed: GLYR1 [Title/Abstract] AND DCTN5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Fusion neoantigen context | PubMed: GLYR1 [Title/Abstract] AND DCTN5 [Title/Abstract] AND neoantigen [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | GLYR1(4872875)-DCTN5(23654274), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | GLYR1-DCTN5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GLYR1-DCTN5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GLYR1-DCTN5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. GLYR1-DCTN5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GLYR1 | GO:0035066 | positive regulation of histone acetylation | 29759984 |
Hgene | GLYR1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 29759984 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:4872875/chr16:23654274) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Amino Acid Sequences |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000436648 | GLYR1 | chr16 | 4872875 | - | ENST00000300087 | DCTN5 | chr16 | 23654274 | + | 3683 | 452 | 2 | 952 | 316 |
ENST00000436648 | GLYR1 | chr16 | 4872875 | - | ENST00000563998 | DCTN5 | chr16 | 23654274 | + | 1210 | 452 | 2 | 862 | 286 |
ENST00000436648 | GLYR1 | chr16 | 4872875 | - | ENST00000568589 | DCTN5 | chr16 | 23654274 | + | 1144 | 452 | 2 | 871 | 289 |
ENST00000436648 | GLYR1 | chr16 | 4872875 | - | ENST00000568272 | DCTN5 | chr16 | 23654274 | + | 913 | 452 | 2 | 658 | 218 |
ENST00000321919 | GLYR1 | chr16 | 4872875 | - | ENST00000300087 | DCTN5 | chr16 | 23654274 | + | 3989 | 758 | 11 | 1258 | 415 |
ENST00000321919 | GLYR1 | chr16 | 4872875 | - | ENST00000563998 | DCTN5 | chr16 | 23654274 | + | 1516 | 758 | 11 | 1168 | 385 |
ENST00000321919 | GLYR1 | chr16 | 4872875 | - | ENST00000568589 | DCTN5 | chr16 | 23654274 | + | 1450 | 758 | 11 | 1177 | 388 |
ENST00000321919 | GLYR1 | chr16 | 4872875 | - | ENST00000568272 | DCTN5 | chr16 | 23654274 | + | 1219 | 758 | 11 | 964 | 317 |
ENST00000381983 | GLYR1 | chr16 | 4872875 | - | ENST00000300087 | DCTN5 | chr16 | 23654274 | + | 3928 | 697 | 4 | 1197 | 397 |
ENST00000381983 | GLYR1 | chr16 | 4872875 | - | ENST00000563998 | DCTN5 | chr16 | 23654274 | + | 1455 | 697 | 4 | 1107 | 367 |
ENST00000381983 | GLYR1 | chr16 | 4872875 | - | ENST00000568589 | DCTN5 | chr16 | 23654274 | + | 1389 | 697 | 4 | 1116 | 370 |
ENST00000381983 | GLYR1 | chr16 | 4872875 | - | ENST00000568272 | DCTN5 | chr16 | 23654274 | + | 1158 | 697 | 4 | 903 | 299 |
ENST00000591451 | GLYR1 | chr16 | 4872875 | - | ENST00000300087 | DCTN5 | chr16 | 23654274 | + | 3912 | 681 | 0 | 1181 | 393 |
ENST00000591451 | GLYR1 | chr16 | 4872875 | - | ENST00000563998 | DCTN5 | chr16 | 23654274 | + | 1439 | 681 | 0 | 1091 | 363 |
ENST00000591451 | GLYR1 | chr16 | 4872875 | - | ENST00000568589 | DCTN5 | chr16 | 23654274 | + | 1373 | 681 | 0 | 1100 | 366 |
ENST00000591451 | GLYR1 | chr16 | 4872875 | - | ENST00000568272 | DCTN5 | chr16 | 23654274 | + | 1142 | 681 | 0 | 887 | 295 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000436648 | ENST00000300087 | GLYR1 | chr16 | 4872875 | - | DCTN5 | chr16 | 23654274 | + | 0.000180316 | 0.9998197 |
ENST00000436648 | ENST00000563998 | GLYR1 | chr16 | 4872875 | - | DCTN5 | chr16 | 23654274 | + | 0.000422024 | 0.99957794 |
ENST00000436648 | ENST00000568589 | GLYR1 | chr16 | 4872875 | - | DCTN5 | chr16 | 23654274 | + | 0.000169607 | 0.99983037 |
ENST00000436648 | ENST00000568272 | GLYR1 | chr16 | 4872875 | - | DCTN5 | chr16 | 23654274 | + | 0.00258728 | 0.99741274 |
ENST00000321919 | ENST00000300087 | GLYR1 | chr16 | 4872875 | - | DCTN5 | chr16 | 23654274 | + | 0.000772052 | 0.999228 |
ENST00000321919 | ENST00000563998 | GLYR1 | chr16 | 4872875 | - | DCTN5 | chr16 | 23654274 | + | 0.00169208 | 0.99830794 |
ENST00000321919 | ENST00000568589 | GLYR1 | chr16 | 4872875 | - | DCTN5 | chr16 | 23654274 | + | 0.000834024 | 0.999166 |
ENST00000321919 | ENST00000568272 | GLYR1 | chr16 | 4872875 | - | DCTN5 | chr16 | 23654274 | + | 0.006346968 | 0.99365306 |
ENST00000381983 | ENST00000300087 | GLYR1 | chr16 | 4872875 | - | DCTN5 | chr16 | 23654274 | + | 0.000120699 | 0.99987924 |
ENST00000381983 | ENST00000563998 | GLYR1 | chr16 | 4872875 | - | DCTN5 | chr16 | 23654274 | + | 0.000230091 | 0.99976987 |
ENST00000381983 | ENST00000568589 | GLYR1 | chr16 | 4872875 | - | DCTN5 | chr16 | 23654274 | + | 0.000111223 | 0.9998888 |
ENST00000381983 | ENST00000568272 | GLYR1 | chr16 | 4872875 | - | DCTN5 | chr16 | 23654274 | + | 0.000610543 | 0.9993894 |
ENST00000591451 | ENST00000300087 | GLYR1 | chr16 | 4872875 | - | DCTN5 | chr16 | 23654274 | + | 0.000126153 | 0.9998739 |
ENST00000591451 | ENST00000563998 | GLYR1 | chr16 | 4872875 | - | DCTN5 | chr16 | 23654274 | + | 0.000272299 | 0.99972767 |
ENST00000591451 | ENST00000568589 | GLYR1 | chr16 | 4872875 | - | DCTN5 | chr16 | 23654274 | + | 0.000131138 | 0.99986887 |
ENST00000591451 | ENST00000568272 | GLYR1 | chr16 | 4872875 | - | DCTN5 | chr16 | 23654274 | + | 0.000755027 | 0.99924505 |
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Get the fusion protein sequences from here. |
Fusion protein sequence information is available in the fasta format. >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP |
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Fusion Protein Breakpoint Sequences for GLYR1-DCTN5 |
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Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Length(fusion protein) | BP in fusion protein | Peptide |
GLYR1 | chr16 | 4872875 | DCTN5 | chr16 | 23654274 | 452 | 150 | PHFHHFLLSQTEKASGNKVSRQSVLC |
GLYR1 | chr16 | 4872875 | DCTN5 | chr16 | 23654274 | 681 | 227 | PHFHHFLLSQTEKASGNKVSRQSVLC |
GLYR1 | chr16 | 4872875 | DCTN5 | chr16 | 23654274 | 697 | 231 | PHFHHFLLSQTEKASGNKVSRQSVLC |
GLYR1 | chr16 | 4872875 | DCTN5 | chr16 | 23654274 | 758 | 249 | PHFHHFLLSQTEKASGNKVSRQSVLC |
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Potential FusionNeoAntigen Information of GLYR1-DCTN5 in HLA I |
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GLYR1-DCTN5_4872875_23654274.msa |
![]() * We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5) |
Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA I | FusionNeoAntigen peptide | Binding score | Immunogenic score | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-B45:01 | TEKASGNKV | 0.9916 | 0.7863 | 10 | 19 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A02:22 | FLLSQTEKA | 0.9901 | 0.7415 | 5 | 14 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A02:11 | FLLSQTEKA | 0.99 | 0.744 | 5 | 14 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A02:60 | FLLSQTEKA | 0.9898 | 0.6856 | 5 | 14 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A02:30 | FLLSQTEKA | 0.9897 | 0.7015 | 5 | 14 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A02:67 | FLLSQTEKA | 0.9897 | 0.7015 | 5 | 14 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A02:24 | FLLSQTEKA | 0.9897 | 0.7015 | 5 | 14 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A02:27 | FLLSQTEKA | 0.9858 | 0.7067 | 5 | 14 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A02:21 | FLLSQTEKA | 0.9846 | 0.8369 | 5 | 14 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A02:13 | FLLSQTEKA | 0.9798 | 0.7568 | 5 | 14 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A02:16 | FLLSQTEKA | 0.9787 | 0.6872 | 5 | 14 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-B50:02 | TEKASGNKV | 0.9625 | 0.708 | 10 | 19 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A02:04 | FLLSQTEKA | 0.9491 | 0.7683 | 5 | 14 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A02:19 | FLLSQTEKA | 0.949 | 0.5254 | 5 | 14 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A02:29 | FLLSQTEKA | 0.9427 | 0.7028 | 5 | 14 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A02:38 | FLLSQTEKA | 0.9333 | 0.6349 | 5 | 14 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A02:35 | FLLSQTEKA | 0.9285 | 0.7146 | 5 | 14 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A02:20 | FLLSQTEKA | 0.9121 | 0.7028 | 5 | 14 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A31:02 | KASGNKVSR | 0.8882 | 0.729 | 12 | 21 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A31:06 | KASGNKVSR | 0.7774 | 0.5542 | 12 | 21 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-B41:01 | TEKASGNKV | 0.5016 | 0.8289 | 10 | 19 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-B50:01 | TEKASGNKV | 0.2133 | 0.7865 | 10 | 19 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A68:24 | EKASGNKVSR | 0.629 | 0.5849 | 11 | 21 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A68:03 | EKASGNKVSR | 0.6121 | 0.565 | 11 | 21 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A68:05 | EKASGNKVSR | 0.4994 | 0.5873 | 11 | 21 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-B39:06 | HHFLLSQTEKA | 0.9995 | 0.8017 | 3 | 14 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-B40:06 | TEKASGNKV | 0.9955 | 0.7071 | 10 | 19 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A02:02 | FLLSQTEKA | 0.9902 | 0.6002 | 5 | 14 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A02:01 | FLLSQTEKA | 0.9897 | 0.7015 | 5 | 14 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A02:05 | FLLSQTEKA | 0.9861 | 0.7315 | 5 | 14 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A31:01 | KASGNKVSR | 0.9715 | 0.7003 | 12 | 21 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A68:01 | EKASGNKVSR | 0.629 | 0.5849 | 11 | 21 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A02:03 | FLLSQTEKA | 0.9902 | 0.7996 | 5 | 14 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A02:06 | FLLSQTEKA | 0.9846 | 0.8369 | 5 | 14 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-A02:14 | FLLSQTEKA | 0.9836 | 0.8048 | 5 | 14 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-B40:04 | TEKASGNKV | 0.975 | 0.6708 | 10 | 19 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-B50:05 | TEKASGNKV | 0.2133 | 0.7865 | 10 | 19 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | HLA-B50:04 | TEKASGNKV | 0.2133 | 0.7865 | 10 | 19 |
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Potential FusionNeoAntigen Information of GLYR1-DCTN5 in HLA II |
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GLYR1-DCTN5_4872875_23654274.msa |
![]() * We used NetMHCIIpan v4.1 (%rank<0.5). |
Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA II | FusionNeoAntigen peptide | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0401 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0401 | HFHHFLLSQTEKASG | 1 | 16 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0407 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0407 | HFHHFLLSQTEKASG | 1 | 16 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0407 | HHFLLSQTEKASGNK | 3 | 18 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0419 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0431 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0433 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0433 | HFHHFLLSQTEKASG | 1 | 16 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0434 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0434 | HFHHFLLSQTEKASG | 1 | 16 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0435 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0435 | HFHHFLLSQTEKASG | 1 | 16 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0438 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0438 | HFHHFLLSQTEKASG | 1 | 16 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0438 | HHFLLSQTEKASGNK | 3 | 18 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0443 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0447 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0447 | HFHHFLLSQTEKASG | 1 | 16 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0454 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0461 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0463 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0463 | HFHHFLLSQTEKASG | 1 | 16 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0464 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0469 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0469 | HFHHFLLSQTEKASG | 1 | 16 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0472 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0474 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0474 | HFHHFLLSQTEKASG | 1 | 16 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0474 | HHFLLSQTEKASGNK | 3 | 18 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0475 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0476 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0476 | HFHHFLLSQTEKASG | 1 | 16 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0901 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0902 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0902 | HFHHFLLSQTEKASG | 1 | 16 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0902 | HHFLLSQTEKASGNK | 3 | 18 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0905 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0907 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0908 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB1-0909 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB3-0217 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB5-0112 | FHHFLLSQTEKASGN | 2 | 17 |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 | DRB5-0112 | HFHHFLLSQTEKASG | 1 | 16 |
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Fusion breakpoint peptide structures of GLYR1-DCTN5 |
![]() * The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA. |
File name | BPseq | Hgene | Tgene | Hchr | Hbp | Tchr | Tbp | AAlen |
5271 | LLSQTEKASGNKVS | GLYR1 | DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 758 |
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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of GLYR1-DCTN5 |
![]() * We used Glide to predict the interaction between HLAs and neoantigens. |
HLA allele | PDB ID | File name | BPseq | Docking score | Glide score |
HLA-B14:02 | 3BVN | 5271 | LLSQTEKASGNKVS | -7.02924 | -7.14264 |
HLA-B14:02 | 3BVN | 5271 | LLSQTEKASGNKVS | -3.38077 | -4.41607 |
HLA-B52:01 | 3W39 | 5271 | LLSQTEKASGNKVS | -6.41355 | -6.52695 |
HLA-B52:01 | 3W39 | 5271 | LLSQTEKASGNKVS | -4.44188 | -5.47718 |
HLA-A24:02 | 5HGA | 5271 | LLSQTEKASGNKVS | -7.76595 | -8.80125 |
HLA-A24:02 | 5HGA | 5271 | LLSQTEKASGNKVS | -7.30892 | -7.42232 |
HLA-B44:05 | 3DX8 | 5271 | LLSQTEKASGNKVS | -5.65486 | -5.76826 |
HLA-B44:05 | 3DX8 | 5271 | LLSQTEKASGNKVS | -2.95775 | -3.99305 |
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Vaccine Design for the FusionNeoAntigens of GLYR1-DCTN5 |
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Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide sequence | FusionNeoAntigen RNA sequence |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 10 | 19 | TEKASGNKV | ACAGAGAAGGCATCTGGGAACAAAGTC |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 11 | 21 | EKASGNKVSR | GAGAAGGCATCTGGGAACAAAGTCAGTCGC |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 12 | 21 | KASGNKVSR | AAGGCATCTGGGAACAAAGTCAGTCGC |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 3 | 14 | HHFLLSQTEKA | CATCATTTCCTGCTAAGCCAAACAGAGAAGGCA |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 5 | 14 | FLLSQTEKA | TTCCTGCTAAGCCAAACAGAGAAGGCA |
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Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide | FusionNEoAntigen RNA sequence |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 1 | 16 | HFHHFLLSQTEKASG | CATTTCCATCATTTCCTGCTAAGCCAAACAGAGAAGGCATCTGGG |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 2 | 17 | FHHFLLSQTEKASGN | TTCCATCATTTCCTGCTAAGCCAAACAGAGAAGGCATCTGGGAAC |
GLYR1-DCTN5 | chr16 | 4872875 | chr16 | 23654274 | 3 | 18 | HHFLLSQTEKASGNK | CATCATTTCCTGCTAAGCCAAACAGAGAAGGCATCTGGGAACAAA |
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Information of the samples that have these potential fusion neoantigens of GLYR1-DCTN5 |
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Cancer type | Fusion gene | Hchr | Hbp | Henst | Tchr | Tbp | Tenst | Sample |
N/A | GLYR1-DCTN5 | chr16 | 4872875 | ENST00000321919 | chr16 | 23654274 | ENST00000300087 | BI832490 |
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Potential target of CAR-T therapy development for GLYR1-DCTN5 |
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![]() * Minus value of BPloci means that the break point is located before the CDS. |
- In-frame and retained 'Transmembrane'. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
![]() * We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image. |
Hgene | Hchr | Hbp | Henst | Tgene | Tchr | Tbp | Tenst | DeepLoc result |
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Related Drugs to GLYR1-DCTN5 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to GLYR1-DCTN5 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |